Browse ZC3HAV1

Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.
Domain PF00644 Poly(ADP-ribose) polymerase catalytic domain
PF02825 WWE domain
Function

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

> Gene Ontology
 
Biological Process GO:0001819 positive regulation of cytokine production
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0009615 response to virus
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0019048 modulation by virus of host morphology or physiology
GO:0019058 viral life cycle
GO:0019079 viral genome replication
GO:0019439 aromatic compound catabolic process
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032606 type I interferon production
GO:0034655 nucleobase-containing compound catabolic process
GO:0035821 modification of morphology or physiology of other organism
GO:0039506 modulation by virus of host molecular function
GO:0039507 suppression by virus of host molecular function
GO:0043330 response to exogenous dsRNA
GO:0043331 response to dsRNA
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044003 modification by symbiont of host morphology or physiology
GO:0044270 cellular nitrogen compound catabolic process
GO:0044359 modulation of molecular function in other organism
GO:0044362 negative regulation of molecular function in other organism
GO:0045069 regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0046700 heterocycle catabolic process
GO:0048525 negative regulation of viral process
GO:0050792 regulation of viral process
GO:0051607 defense response to virus
GO:0051701 interaction with host
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction
GO:0052055 modulation by symbiont of host molecular function
GO:0052056 negative regulation by symbiont of host molecular function
GO:0052204 negative regulation of molecular function in other organism involved in symbiotic interaction
GO:0052205 modulation of molecular function in other organism involved in symbiotic interaction
GO:0061013 regulation of mRNA catabolic process
GO:0061014 positive regulation of mRNA catabolic process
GO:0071359 cellular response to dsRNA
GO:0071360 cellular response to exogenous dsRNA
GO:0071407 cellular response to organic cyclic compound
GO:0098542 defense response to other organism
GO:1901361 organic cyclic compound catabolic process
GO:1903311 regulation of mRNA metabolic process
GO:1903313 positive regulation of mRNA metabolic process
GO:1903900 regulation of viral life cycle
GO:1903901 negative regulation of viral life cycle
Molecular Function GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016763 transferase activity, transferring pentosyl groups
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005770 late endosome
GO:0005913 cell-cell adherens junction
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-6802957: Oncogenic MAPK signaling
R-HSA-6802952: Signaling by BRAF and RAF fusions
Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ZC3HAV1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ZC3HAV1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 5.02; FDR: 0.002 Resistant to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ZC3HAV1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0890.638
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1450.933
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2620.84
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1620.512
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0050.998
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3750.905
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3870.359
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5970.733
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1320.947
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6490.58
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0780.544
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0020.97
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ZC3HAV1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ZC3HAV1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ZC3HAV1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ZC3HAV1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ZC3HAV1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ZC3HAV1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ZC3HAV1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolZC3HAV1
Namezinc finger CCCH-type, antiviral 1
Aliases FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; zinc finger antiviral protein; CCCH-type zinc finger an ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ZC3HAV1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.