Browse ZEB1

Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00046 Homeobox domain
PF05605 Drought induced 19 protein (Di19)
Function

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001501 skeletal system development
GO:0001654 eye development
GO:0002521 leukocyte differentiation
GO:0002694 regulation of leukocyte activation
GO:0007159 leukocyte cell-cell adhesion
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0010463 mesenchymal cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0010720 positive regulation of cell development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0022407 regulation of cell-cell adhesion
GO:0030098 lymphocyte differentiation
GO:0030217 T cell differentiation
GO:0030856 regulation of epithelial cell differentiation
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031076 embryonic camera-type eye development
GO:0033077 T cell differentiation in thymus
GO:0033081 regulation of T cell differentiation in thymus
GO:0035239 tube morphogenesis
GO:0042110 T cell activation
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042692 muscle cell differentiation
GO:0043010 camera-type eye development
GO:0043200 response to amino acid
GO:0043583 ear development
GO:0045580 regulation of T cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0048048 embryonic eye morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048752 semicircular canal morphogenesis
GO:0048839 inner ear development
GO:0050769 positive regulation of neurogenesis
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0051145 smooth muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051216 cartilage development
GO:0051249 regulation of lymphocyte activation
GO:0051962 positive regulation of nervous system development
GO:0060872 semicircular canal development
GO:0061448 connective tissue development
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0071229 cellular response to acid chemical
GO:0071230 cellular response to amino acid stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090102 cochlea development
GO:0090103 cochlea morphogenesis
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090596 sensory organ morphogenesis
GO:1902105 regulation of leukocyte differentiation
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903706 regulation of hemopoiesis
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus
GO:2000398 regulation of thymocyte aggregation
Molecular Function GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0008134 transcription factor binding
GO:0070888 E-box binding
Cellular Component GO:0005667 transcription factor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-449147: Signaling by Interleukins
Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ZEB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between ZEB1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25348003Lung CarcinomaInhibit immunity (T cell function)We show that microRNA-200 (miR-200), a cell-autonomous suppressor of EMT and metastasis, targets PD-L1. Moreover, ZEB1, an EMT activator and transcriptional repressor of miR-200, relieves miR-200 repression of PD-L1 on tumour cells, leading to CD8(+) T-cell immunosuppression and metastasis.
Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ZEB1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ZEB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7430.059
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.7120.595
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7560.397
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6540.166
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7180.769
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5740.85
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.390.403
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6740.644
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0750.963
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5850.631
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.8770.242
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3320.0215
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ZEB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.45.51.90.66
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ZEB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ZEB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ZEB1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ZEB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ZEB1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ZEB1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolZEB1
Namezinc finger E-box binding homeobox 1
Aliases BZP; ZEB; AREB6; NIL-2-A; Zfhep; Zfhx1a; FECD6; TCF8; PPCD3; transcription factor 8 (represses interleukin 2 ......
Chromosomal Location10p11.22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ZEB1 collected from DrugBank database.
> Drugs from DrugBank database
 

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