| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | - |
| Domain |
PF04438 HIT zinc finger |
| Function |
Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. |
| Biological Process |
GO:0000491 small nucleolar ribonucleoprotein complex assembly GO:0000492 box C/D snoRNP assembly GO:0006403 RNA localization GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0042254 ribosome biogenesis GO:0048254 snoRNA localization GO:0051259 protein oligomerization GO:0071826 ribonucleoprotein complex subunit organization |
| Molecular Function |
GO:0001085 RNA polymerase II transcription factor binding GO:0001091 RNA polymerase II basal transcription factor binding GO:0001094 TFIID-class transcription factor binding GO:0001098 basal transcription machinery binding GO:0001099 basal RNA polymerase II transcription machinery binding GO:0008134 transcription factor binding GO:0051117 ATPase binding |
| Cellular Component |
GO:0070761 pre-snoRNP complex |
| KEGG | - |
| Reactome | - |
| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between ZNHIT6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
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There is no record. |
| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of ZNHIT6 in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of ZNHIT6 in various data sets.
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There is no record. |
| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ZNHIT6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ZNHIT6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ZNHIT6. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ZNHIT6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of ZNHIT6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between ZNHIT6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
| Summary | |
|---|---|
| Symbol | ZNHIT6 |
| Name | zinc finger, HIT-type containing 6 |
| Aliases | FLJ20729; NY-BR-75; box C/D snoRNA essential 1 homolog (S. cerevisiae); C1orf181; chromosome 1 open reading ...... |
| Chromosomal Location | 1p22.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Drugs targeting ZNHIT6 collected from DrugBank database. |
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There is no record. |