microRNA information: hsa-miR-181a-3p

SectionIDlink
Mature name: hsa-miR-181a-3pmiRbase
Accession: MIMAT0000270miRbase
Precursor name: hsa-mir-181a-1 miRbase
Precursor accession: MI0000289miRbase
Symbol: NAHGNC
RefSeq ID: NAGenBank
Sequence: ACCAUCGACCGUUGAUUGUACC



Reported expression in cancers: hsa-miR-181a-3p

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-181a-3p

acute myeloid leukemiaupregulation"This paper evaluated the association between micro ......"25646775RNA-Seq
hsa-miR-181a-3p

acute myeloid leukemiaupregulation"Targeting the RAS/MAPK pathway with miR 181a in ac ......"27517749
hsa-miR-181a-3p

breast cancerdownregulation"Increased expression of three of the most promisin ......"18708351Reverse transcription PCR; qPCR
hsa-miR-181a-3p

breast cancerupregulation"This was mediated by the micro miRNA family miR-18 ......"21102523
hsa-miR-181a-3p

breast cancerupregulation"TGF β upregulates miR 181a expression to promote ......"23241956
hsa-miR-181a-3p

breast cancerdownregulation"RNA was extracted reverse transcribed and subjecte ......"24498016Microarray
hsa-miR-181a-3p

breast cancerderegulation"The expression profiles of miR-9 miR-21 miR-30a mi ......"25013435Reverse transcription PCR
hsa-miR-181a-3p

cervical and endocervical cancerdownregulation"miR-181a has been reported to participate in tumor ......"27534652
hsa-miR-181a-3p

colorectal cancerupregulation"Recent studies have shown that miR-181a is dysregu ......"23023298qPCR
hsa-miR-181a-3p

gastric cancerupregulation"miRNA expression was determined using a custom-des ......"22112324Microarray
hsa-miR-181a-3p

gastric cancerupregulation"Genetic polymorphism at miR 181a binding site cont ......"22971574Reverse transcription PCR; Microarray
hsa-miR-181a-3p

glioblastomaderegulation"In our study we examined by microarray the global ......"16039986Microarray
hsa-miR-181a-3p

head and neck cancerderegulation"A global miRNA profiling was performed on 12 sampl ......"21637912qPCR; Microarray
hsa-miR-181a-3p

liver cancerupregulation"Here using a global microarray-based miRNA profili ......"19585654Reverse transcription PCR; Microarray
hsa-miR-181a-3p

liver cancerupregulation"We demonstrated that conserved let-7 and miR-181 f ......"21352471qPCR; Microarray
hsa-miR-181a-3p

liver cancerupregulation"Up-regulation of miR-15a miR-16 miR-27b miR-30b mi ......"24314246qPCR
hsa-miR-181a-3p

liver cancerupregulation"Recent studies have found that miR-181a were dysre ......"24529171qPCR
hsa-miR-181a-3p

liver cancerupregulation"miR 181a mediates TGF β induced hepatocyte EMT an ......"24576072
hsa-miR-181a-3p

lung squamous cell cancerderegulation"Locked nucleic acids miRNA microarray expression p ......"20508945Microarray
hsa-miR-181a-3p

lung squamous cell cancerderegulation"In this study we analyzed the global expression pr ......"25524579
hsa-miR-181a-3p

lymphomaupregulation"The major findings were: the detection of a panel ......"19945163
hsa-miR-181a-3p

pancreatic cancerdownregulation"The in vivo effect of miR-181a down-regulation on ......"26152285
hsa-miR-181a-3p

prostate cancerupregulation"In the present study the expression of miR-181 in ......"25187843
hsa-miR-181a-3p

sarcomadownregulation"Here we profiled miRNA expression of chondrosarcom ......"23940002qPCR; Microarray
hsa-miR-181a-3p

sarcomaupregulation"The expression of miR 181a 5p and miR 371b 5p in c ......"26214773



Reported cancer pathway affected by hsa-miR-181a-3p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-181a-3p

acute myeloid leukemiacell cycle pathway"miR 181a promotes G1/S transition and cell prolife ......"26113450Flow cytometry; Luciferase
hsa-miR-181a-3p

breast cancerEpithelial mesenchymal transition pathway"TGF β upregulates miR 181a expression to promote ......"23241956
hsa-miR-181a-3p

breast cancerApoptosis pathway"The function role of miR 181a in chemosensitivity ......"24335172Western blot; Luciferase
hsa-miR-181a-3p

breast cancerApoptosis pathway"Here we show that genotoxic treatments significant ......"26028030
hsa-miR-181a-3p

cervical and endocervical cancerApoptosis pathway"MiR 181a confers resistance of cervical cancer to ......"22847611
hsa-miR-181a-3p

cervical and endocervical cancercell cycle pathway; Apoptosis pathway"miR-181a has been reported to participate in tumor ......"27534652Western blot
hsa-miR-181a-3p

colorectal cancerEpithelial mesenchymal transition pathway"Expression profile was further assessed using quan ......"24755295Luciferase
hsa-miR-181a-3p

colorectal cancerApoptosis pathway; PI3K/Akt signaling pathway"The emerging role of microRNA-181A miR-181A in CRC ......"26750720
hsa-miR-181a-3p

gastric cancerApoptosis pathway"In order to identify miRNA signatures for gastric ......"22112324
hsa-miR-181a-3p

gastric cancerApoptosis pathway"However it remains unknown whether miR-181a is inv ......"22581522Colony formation; Luciferase; Western blot
hsa-miR-181a-3p

gastric cancerApoptosis pathway"Based on our previous experiments this study is to ......"24531888Western blot; Luciferase
hsa-miR-181a-3p

glioblastomaEpithelial mesenchymal transition pathway"We annotated 491 TCGA samples' miRNA expression pr ......"26283154
hsa-miR-181a-3p

liver cancerApoptosis pathway"Functional analysis of miR 181a and Fas involved i ......"25449696
hsa-miR-181a-3p

lung cancerEpithelial mesenchymal transition pathway"The metastatic properties of the cells were assess ......"26323677Western blot; Cell migration assay; Wound Healing Assay; Luciferase
hsa-miR-181a-3p

lung squamous cell cancerApoptosis pathway"In this study we analyzed the global expression pr ......"25524579
hsa-miR-181a-3p

lymphomaApoptosis pathway"Bim down-regulation is posttranscriptionally regul ......"20841506
hsa-miR-181a-3p

prostate cancerApoptosis pathway"MiR 181a contributes to bufalin induced apoptosis ......"24267199Western blot
hsa-miR-181a-3p

prostate cancercell cycle pathway"In the present study the expression of miR-181 in ......"25187843
hsa-miR-181a-3p

retinoblastomacell cycle pathway"Among them hsa-miR-373 hsa-miR-125b and hsa-miR-18 ......"26730174
hsa-miR-181a-3p

sarcomaApoptosis pathway"MicroRNA 181a miR-181a was found dysregulated in a ......"23740615Western blot



Reported cancer prognosis affected by hsa-miR-181a-3p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-181a-3p

B cell lymphomapoor survival; progression"We measured the expression of each miRNA by quanti ......"21525173
hsa-miR-181a-3p

acute myeloid leukemiadifferentiation"The major features of these profiles were upregula ......"18809607
hsa-miR-181a-3p

acute myeloid leukemiapoor survival"Prognostic significance of expression of a single ......"21079133
hsa-miR-181a-3p

acute myeloid leukemiaworse prognosis"Recently we showed that increased miR-181a express ......"23100311
hsa-miR-181a-3p

acute myeloid leukemiadifferentiation"MiR 181 family: regulators of myeloid differentiat ......"25174404
hsa-miR-181a-3p

acute myeloid leukemiaworse prognosis; differentiation; poor survival"The pathological role and prognostic impact of miR ......"25686674
hsa-miR-181a-3p

breast cancerrecurrence; poor survival; worse prognosis"MicroRNA microarray analysis was performed to comp ......"21271219
hsa-miR-181a-3p

breast cancerstaging"Decreased serum miR 181a is a potential new tool f ......"22692639
hsa-miR-181a-3p

breast cancermetastasis; staging; poor survival"TGF β upregulates miR 181a expression to promote ......"23241956
hsa-miR-181a-3p

breast cancerprogression"MicroRNA-181 miR-181 is a multifaceted miRNA that ......"23524334
hsa-miR-181a-3p

breast cancerdrug resistance"MiR 181a enhances drug sensitivity in mitoxantone ......"23780685Luciferase
hsa-miR-181a-3p

breast cancertumorigenesis"The function role of miR 181a in chemosensitivity ......"24335172Western blot; Luciferase
hsa-miR-181a-3p

breast cancermetastasis"The expression of miRNAs in patients with primary ......"24846313
hsa-miR-181a-3p

breast cancermetastasis; poor survival; drug resistance"Here we show that genotoxic treatments significant ......"26028030
hsa-miR-181a-3p

breast cancerpoor survival"In this multicenter study a 10-miRNA classifier in ......"27566954
hsa-miR-181a-3p

cervical and endocervical cancerdrug resistance"MiR 181a confers resistance of cervical cancer to ......"22847611
hsa-miR-181a-3p

cervical and endocervical cancerprogression"miR-181a has been reported to participate in tumor ......"27534652Western blot
hsa-miR-181a-3p

colorectal cancerpoor survival; drug resistance; differentiation"miR 181a is associated with poor clinical outcome ......"24098024
hsa-miR-181a-3p

colorectal cancermetastasis; staging; poor survival; motility"Expression profile was further assessed using quan ......"24755295Luciferase
hsa-miR-181a-3p

colorectal cancermetastasis; poor survival"The emerging role of microRNA-181A miR-181A in CRC ......"26750720
hsa-miR-181a-3p

colorectal cancertumorigenesis"It was found that miR-181a may be involved in the ......"27264420Luciferase
hsa-miR-181a-3p

endometrial cancerpoor survival; tumorigenesis; worse prognosis; metastasis; progression"The aberrant expression of human microRNA-181a-1 h ......"25733820
hsa-miR-181a-3p

gastric cancerdrug resistance"In order to identify miRNA signatures for gastric ......"22112324
hsa-miR-181a-3p

gastric cancermalignant trasformation"However it remains unknown whether miR-181a is inv ......"22581522Colony formation; Luciferase; Western blot
hsa-miR-181a-3p

gastric cancerworse prognosis"Genetic polymorphism at miR 181a binding site cont ......"22971574Luciferase
hsa-miR-181a-3p

gastric cancerstaging; cell migration"Here we show that miR-181a levels were significant ......"25706394
hsa-miR-181a-3p

gastric cancerdrug resistance"MiR 181a suppresses autophagy and sensitizes gastr ......"26589846
hsa-miR-181a-3p

gastric cancerdrug resistance; progression"Role of miR 27a miR 181a and miR 20b in gastric ca ......"26793992
hsa-miR-181a-3p

glioblastomamalignant trasformation"In our study we examined by microarray the global ......"16039986
hsa-miR-181a-3p

glioblastomatumorigenesis"miR 181 subunits enhance the chemosensitivity of t ......"24573637
hsa-miR-181a-3p

glioblastomapoor survival"We annotated 491 TCGA samples' miRNA expression pr ......"26283154
hsa-miR-181a-3p

head and neck cancermalignant trasformation"A global miRNA profiling was performed on 12 sampl ......"21637912
hsa-miR-181a-3p

head and neck cancerpoor survival"Our findings showed that significant elevated expr ......"25677760
hsa-miR-181a-3p

liver cancerdifferentiation"Here using a global microarray-based miRNA profili ......"19585654
hsa-miR-181a-3p

liver cancermotility; drug resistance"We evaluated the expression of microRNA in human H ......"21352471
hsa-miR-181a-3p

liver cancerdrug resistance"The cell viability MTT assay was used to detect dr ......"23229111MTT assay
hsa-miR-181a-3p

liver cancerworse prognosis"Expression of serum microRNAs miR 222 miR 181 miR ......"24124720
hsa-miR-181a-3p

liver cancerprogression"Recent studies have found that miR-181a were dysre ......"24529171Western blot; Luciferase; Colony formation
hsa-miR-181a-3p

liver cancerdrug resistance"miR 181a mediates TGF β induced hepatocyte EMT an ......"24576072
hsa-miR-181a-3p

liver cancermotility"MiR 181a 5p is downregulated in hepatocellular car ......"25058462
hsa-miR-181a-3p

lung cancerprogression; drug resistance"The metastatic properties of the cells were assess ......"26323677Western blot; Cell migration assay; Wound Healing Assay; Luciferase
hsa-miR-181a-3p

lung squamous cell cancerworse prognosis; staging; poor survival"Deregulated expression of miR 21 miR 143 and miR 1 ......"20363096
hsa-miR-181a-3p

lymphomapoor survival"Bim down-regulation is posttranscriptionally regul ......"20841506
hsa-miR-181a-3p

melanomametastasis"Circulating T cell natural killer NK natural kille ......"24370793Flow cytometry
hsa-miR-181a-3p

ovarian cancerrecurrence; poor survival; drug resistance"Here we show that miR-181a promotes TGF-β-mediate ......"24394555
hsa-miR-181a-3p

ovarian cancerdrug resistance"MiR 181a upregulation is associated with epithelia ......"27249598Flow cytometry; MTT assay
hsa-miR-181a-3p

pancreatic cancercell migration"LPS induced miR 181a promotes pancreatic cancer ce ......"24532253
hsa-miR-181a-3p

prostate cancerprogression"In the present study the expression of miR-181 in ......"25187843
hsa-miR-181a-3p

retinoblastomametastasis"Among them hsa-miR-373 hsa-miR-125b and hsa-miR-18 ......"26730174
hsa-miR-181a-3p

sarcomaprogression"MicroRNA 181a miR-181a was found dysregulated in a ......"23740615Western blot
hsa-miR-181a-3p

sarcomametastasis; progression"miR 181a Targets RGS16 to Promote Chondrosarcoma G ......"26013170



Reported gene related to hsa-miR-181a-3p

miRNAcancergenereportingPUBMED
hsa-miR-181a-3p

cervical and endocervical cancerPTEN"From our results down-regulation of miR-181a incre ......"27534652
hsa-miR-181a-3p

colon cancerPTEN"miR-181a performs this function by inhibiting the ......"24685694
hsa-miR-181a-3p

colorectal cancerPTEN"The expression of PTEN was regulated by IL-1β-sti ......"27264420
hsa-miR-181a-3p

colorectal cancerPTEN"The expression of miR-181A and PTEN in CRC patient ......"26750720
hsa-miR-181a-3p

lung cancerPTEN"Luciferase assays were performed to assess the abi ......"26323677
hsa-miR-181a-3p

pancreatic cancerPTEN"LPS induced miR 181a promotes pancreatic cancer ce ......"24532253
hsa-miR-181a-3p

acute myeloid leukemiaATM"MiR 181a Promotes Proliferation of Human Acute Mye ......"27150990
hsa-miR-181a-3p

acute myeloid leukemiaATM"miR 181a promotes G1/S transition and cell prolife ......"26113450
hsa-miR-181a-3p

breast cancerATM"Ataxia telangiectasia mutated ATM a target gene of ......"21102523
hsa-miR-181a-3p

breast cancerATM"We report that miR-181a and miR-181b were overexpr ......"23656790
hsa-miR-181a-3p

gastric cancerATM"Ataxia-telangiectasia mutation ATM was predicted a ......"24531888
hsa-miR-181a-3p

breast cancerBCL2"The function role of miR 181a in chemosensitivity ......"24335172
hsa-miR-181a-3p

cervical and endocervical cancerBCL2"In addition inhibition of miR-181a promoted apopto ......"27534652
hsa-miR-181a-3p

lung squamous cell cancerBCL2"Moreover we also found miR-181 reduction was assoc ......"25524579
hsa-miR-181a-3p

prostate cancerBCL2"Bufalin was found to induce the expression of miR- ......"24267199
hsa-miR-181a-3p

sarcomaBCL2"The results from Western blotting indicated that m ......"23740615
hsa-miR-181a-3p

acute myeloid leukemiaKRAS"Here we report that miR-181a directly binds to 3'- ......"27517749
hsa-miR-181a-3p

colorectal cancerKRAS"The KRAS mutational status was determined by pyros ......"24098024
hsa-miR-181a-3p

lung squamous cell cancerKRAS"MiR 181a 5p inhibits cell proliferation and migrat ......"26124189
hsa-miR-181a-3p

breast cancerBAX"We further identified BAX as a direct functional t ......"26028030
hsa-miR-181a-3p

cervical and endocervical cancerBAX"In addition inhibition of miR-181a promoted apopto ......"27534652
hsa-miR-181a-3p

breast cancerBCL2L11"Mechanistically inactivation of miR-181a elevated ......"23241956
hsa-miR-181a-3p

lymphomaBCL2L11"Furthermore we found that cell adhesion-up-regulat ......"20841506
hsa-miR-181a-3p

breast cancerIL6"The upregulation of miR-181a was orchestrated by t ......"26028030
hsa-miR-181a-3p

liver cancerIL6"Knocking down IL-6 and Twist in HSCs significantly ......"21352471
hsa-miR-181a-3p

sarcomaVEGFA"miR-181a is overexpressed in high-grade chondrosar ......"26013170
hsa-miR-181a-3p

sarcomaVEGFA"miR-181a transfection of JJ cells doubled expressi ......"25106798
hsa-miR-181a-3p

ovarian cancerABCB1"SKOV3 cells had increased P-gp expression after en ......"27249598
hsa-miR-181a-3p

breast cancerABCG2"Luciferase activity assay showed that miR-181a mim ......"23780685
hsa-miR-181a-3p

gastric cancerATG5"Then we indicated that ATG5 was a potential target ......"26589846
hsa-miR-181a-3p

prostate cancerCASP3"In prostate cancer PC-3cell line bufalin-induced a ......"24267199
hsa-miR-181a-3p

colorectal cancerCDH1"Ectopic expression of miR-181a suppressed the epit ......"24755295
hsa-miR-181a-3p

ovarian cancerCDH2"SKOV3/PTX cells had significantly higher expressio ......"27249598
hsa-miR-181a-3p

acute myeloid leukemiaCEBPA"Interestingly miR-181a expression was increased in ......"23100311
hsa-miR-181a-3p

sarcomaCXCR4"These data establish miR-181a as an oncomiR that p ......"26013170
hsa-miR-181a-3p

liver cancerE2F5"Mechanism investigation revealed that miR-181a inh ......"24529171
hsa-miR-181a-3p

colorectal cancerEGF"However the role of miR-181a expression in CRC and ......"24098024
hsa-miR-181a-3p

colorectal cancerEGFR"miR 181a is associated with poor clinical outcome ......"24098024
hsa-miR-181a-3p

liver cancerFAS"Functional analysis of miR 181a and Fas involved i ......"25449696
hsa-miR-181a-3p

sarcomaFBXW11"First the expression of miR-181a in osteosarcoma c ......"23740615
hsa-miR-181a-3p

cervical and endocervical cancerFOXO1"From our results down-regulation of miR-181a incre ......"27534652
hsa-miR-181a-3p

gastric cancerKLF6"Site-directed mutagenesis and luciferase reporter ......"22581522
hsa-miR-181a-3p

prostate cancerLEF1"LEF1 targeting EMT in prostate cancer invasion is ......"26045991
hsa-miR-181a-3p

pancreatic cancerMAP2K4"LPS induced miR 181a promotes pancreatic cancer ce ......"24532253
hsa-miR-181a-3p

liver cancerMET"MiR 181a 5p is downregulated in hepatocellular car ......"25058462
hsa-miR-181a-3p

sarcomaMMP9"The results from Western blotting indicated that m ......"23740615
hsa-miR-181a-3p

gastric cancerMTMR3"We further demonstrated that the rs12537CT genotyp ......"22971574
hsa-miR-181a-3p

breast cancerMX1"Overexpression of miR-181a down-regulated BCRP exp ......"23780685
hsa-miR-181a-3p

acute myeloid leukemiaNPM1"The impact of miR-181a was most striking in poor m ......"21079133
hsa-miR-181a-3p

acute myeloid leukemiaNRAS"Here we report that miR-181a directly binds to 3'- ......"27517749
hsa-miR-181a-3p

breast cancerPGR"In addition a transcriptome analysis revealed that ......"19826037
hsa-miR-181a-3p

breast cancerPLAU"uPA mRNA was a direct target of miR-193a/b and miR ......"21779487
hsa-miR-181a-3p

cervical and endocervical cancerPRKCD"MiR 181a confers resistance of cervical cancer to ......"22847611
hsa-miR-181a-3p

gastric cancerPROX1"In addition the ectopic expression of miR-181a in ......"25706394
hsa-miR-181a-3p

chronic myeloid leukemiaRALA"The delivery of miR-181a specifically inhibited th ......"26554155
hsa-miR-181a-3p

glioblastomaRAP1B"miR 181 subunits enhance the chemosensitivity of t ......"24573637
hsa-miR-181a-3p

colorectal cancerRELA"The expression levels of IL-1β NF-κB RelA and mi ......"27264420
hsa-miR-181a-3p

sarcomaRGS16"miR 181a Targets RGS16 to Promote Chondrosarcoma G ......"26013170
hsa-miR-181a-3p

ovarian cancerSMAD2"Here we show that miR-181a promotes TGF-β-mediate ......"24394555
hsa-miR-181a-3p

ovarian cancerSMAD7"Here we show that miR-181a promotes TGF-β-mediate ......"24394555
hsa-miR-181a-3p

breast cancerSTAT3"The upregulation of miR-181a was orchestrated by t ......"26028030
hsa-miR-181a-3p

thyroid cancerTHRB"We observed lower levels of THRB transcripts in ce ......"21159845
hsa-miR-181a-3p

liver cancerTNF"TNF receptor superfamily member 6 Fas was further ......"25449696
hsa-miR-181a-3p

pancreatic cancerTNFAIP1"Targeting of miR-181a on TNFAIP1 in pancreatic can ......"26152285
hsa-miR-181a-3p

endometrial cancerTRGV9"To predict the targets of hsa-miR-181a ten differe ......"25733820
hsa-miR-181a-3p

liver cancerTWIST1"Knocking down IL-6 and Twist in HSCs significantly ......"21352471
hsa-miR-181a-3p

colorectal cancerVIM"Ectopic expression of miR-181a suppressed the epit ......"24755295
hsa-miR-181a-3p

colorectal cancerWIF1"Additionally we identified WIF-1 as direct and fun ......"24755295



Expression profile in cancer corhorts: