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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-30e-5p ABCD2 1.24 0 -3.08 0 MirTarget -0.82 0 NA
2 hsa-miR-30e-5p ABL1 1.24 0 -1.32 0 MirTarget; miRNATAP -0.35 0 NA
3 hsa-miR-30e-5p ABL2 1.24 0 -0.32 0.04554 mirMAP -0.27 0 NA
4 hsa-miR-30e-5p ACTBL2 1.24 0 1.68 0.00368 MirTarget -0.85 0 NA
5 hsa-miR-30e-5p ACTC1 1.24 0 -7.19 0 MirTarget -2.91 0 NA
6 hsa-miR-30e-5p ACVR1 1.24 0 -0.44 0.01143 MirTarget -0.41 0 NA
7 hsa-miR-30e-5p ADAM19 1.24 0 -1.06 0.01895 MirTarget -1.18 0 NA
8 hsa-miR-30e-5p ADAMTS6 1.24 0 -0.88 0.01914 MirTarget -0.9 0 NA
9 hsa-miR-30e-5p ADRA1D 1.24 0 -4.03 0 MirTarget -0.89 0 NA
10 hsa-miR-30e-5p ADRA2A 1.24 0 -2.58 0 MirTarget -0.47 1.0E-5 NA
11 hsa-miR-30e-5p AFAP1L2 1.24 0 0.06 0.85809 MirTarget -0.42 0 NA
12 hsa-miR-30e-5p AFF2 1.24 0 -1.73 0.00201 mirMAP -0.33 0.01239 NA
13 hsa-miR-30e-5p AIDA 1.24 0 -0.31 0.01307 MirTarget -0.16 0 NA
14 hsa-miR-30e-5p ALDH1A3 1.24 0 -1.34 0.0022 mirMAP -0.39 0.00013 NA
15 hsa-miR-30e-5p AMOTL1 1.24 0 -1.62 0 MirTarget -0.68 0 NA
16 hsa-miR-30e-5p AMOTL2 1.24 0 -1.01 0.00015 MirTarget -0.5 0 NA
17 hsa-miR-30e-5p ANO4 1.24 0 -2.45 0 MirTarget -0.42 0.00044 NA
18 hsa-miR-30e-5p ANTXR1 1.24 0 -0.71 0.0159 mirMAP -0.74 0 NA
19 hsa-miR-30e-5p ANTXR2 1.24 0 -2.31 0 mirMAP -0.88 0 NA
20 hsa-miR-30e-5p APBB2 1.24 0 -0.59 0.0014 mirMAP -0.38 0 NA
21 hsa-miR-30e-5p ARF4 1.24 0 0.06 0.68077 MirTarget -0.11 0.00036 NA
22 hsa-miR-30e-5p ARID5B 1.24 0 -1.57 0 MirTarget; miRNATAP -0.34 0 NA
23 hsa-miR-30e-5p ARL13B 1.24 0 -0.26 0.17485 MirTarget -0.2 1.0E-5 NA
24 hsa-miR-30e-5p ARL15 1.24 0 -0.61 0.00667 MirTarget -0.2 0.0001 NA
25 hsa-miR-30e-5p ARL4A 1.24 0 -0.62 0.01525 MirTarget -0.18 0.0023 NA
26 hsa-miR-30e-5p ASB1 1.24 0 -0.87 0 mirMAP -0.21 0 NA
27 hsa-miR-30e-5p ASCC3 1.24 0 -0.05 0.75233 MirTarget -0.18 0 NA
28 hsa-miR-30e-5p ATF2 1.24 0 -0.36 0.09137 mirMAP -0.25 0 NA
29 hsa-miR-30e-5p ATL3 1.24 0 -0.19 0.4343 mirMAP -0.4 0 NA
30 hsa-miR-30e-5p ATP11C 1.24 0 -0.48 0.00363 mirMAP -0.1 0.00844 NA
31 hsa-miR-30e-5p ATP2A2 1.24 0 -0.4 0.01225 mirMAP -0.2 0 NA
32 hsa-miR-30e-5p ATP6V1B2 1.24 0 -0.17 0.24474 MirTarget -0.23 0 NA
33 hsa-miR-30e-5p ATXN1 1.24 0 -1.51 0 mirMAP; miRNATAP -0.58 0 NA
34 hsa-miR-30e-5p B4GALT5 1.24 0 -0.51 0.00437 miRNATAP -0.26 0 NA
35 hsa-miR-30e-5p BCAP29 1.24 0 -0.32 0.0123 mirMAP -0.21 0 NA
36 hsa-miR-30e-5p BDNF 1.24 0 -2.91 0 miRNATAP -0.71 0 NA
37 hsa-miR-30e-5p BICD1 1.24 0 0.12 0.64772 mirMAP -0.39 0 NA
38 hsa-miR-30e-5p BMPR2 1.24 0 -0.59 4.0E-5 mirMAP -0.23 0 NA
39 hsa-miR-30e-5p BNC1 1.24 0 -0.29 0.77524 MirTarget -1.48 0 NA
40 hsa-miR-30e-5p BNC2 1.24 0 -2.95 0 mirMAP -1.46 0 NA
41 hsa-miR-30e-5p BNIP3L 1.24 0 -0.6 0.00028 MirTarget -0.13 0.00062 NA
42 hsa-miR-30e-5p C9orf47 1.24 0 -2.02 2.0E-5 mirMAP -0.32 0.00354 NA
43 hsa-miR-30e-5p CACHD1 1.24 0 -1.73 0 MirTarget -0.44 0 NA
44 hsa-miR-30e-5p CACNA1C 1.24 0 -2.53 0 mirMAP -0.84 0 NA
45 hsa-miR-30e-5p CACNB2 1.24 0 -2.97 0 MirTarget; miRNATAP -0.52 0 NA
46 hsa-miR-30e-5p CACNB4 1.24 0 -2.87 0 mirMAP -0.4 0.00017 NA
47 hsa-miR-30e-5p CALU 1.24 0 -0.15 0.46318 MirTarget -0.47 0 NA
48 hsa-miR-30e-5p CAMK2A 1.24 0 -4.14 0 mirMAP -1.66 0 NA
49 hsa-miR-30e-5p CAMK2D 1.24 0 -0.89 3.0E-5 miRNATAP -0.19 0.00015 NA
50 hsa-miR-30e-5p CAMK4 1.24 0 -1.28 0.0022 MirTarget; mirMAP -0.52 0 NA
51 hsa-miR-30e-5p CANX 1.24 0 0.06 0.62545 miRNAWalker2 validate -0.11 2.0E-5 NA
52 hsa-miR-30e-5p CCDC141 1.24 0 -2.94 0 mirMAP -0.68 0 NA
53 hsa-miR-30e-5p CCDC6 1.24 0 -0.27 0.05122 MirTarget -0.14 2.0E-5 NA
54 hsa-miR-30e-5p CCNA1 1.24 0 -0.8 0.29528 MirTarget -0.83 0 NA
55 hsa-miR-30e-5p CDC37L1 1.24 0 -1.08 0 MirTarget -0.26 0 NA
56 hsa-miR-30e-5p CDC73 1.24 0 -0.43 0.00223 MirTarget -0.18 0 NA
57 hsa-miR-30e-5p CDK17 1.24 0 -0.52 0.00027 mirMAP -0.18 0 NA
58 hsa-miR-30e-5p CDK6 1.24 0 -0.77 0.06479 mirMAP -0.82 0 NA
59 hsa-miR-30e-5p CELF2 1.24 0 -3.05 0 mirMAP -0.83 0 NA
60 hsa-miR-30e-5p CFL2 1.24 0 -2.62 0 MirTarget -0.82 0 NA
61 hsa-miR-30e-5p CHL1 1.24 0 -2.42 0.00043 MirTarget -0.77 0 NA
62 hsa-miR-30e-5p CHST1 1.24 0 0.15 0.68777 MirTarget -0.43 0 NA
63 hsa-miR-30e-5p CLOCK 1.24 0 -0.51 0.03689 MirTarget -0.19 0.00089 NA
64 hsa-miR-30e-5p CLTC 1.24 0 0.15 0.24035 mirMAP -0.11 0.00027 NA
65 hsa-miR-30e-5p COL19A1 1.24 0 -5.13 0 mirMAP -1.12 0 NA
66 hsa-miR-30e-5p COL8A1 1.24 0 -0.75 0.115 MirTarget -0.93 0 NA
67 hsa-miR-30e-5p CPEB2 1.24 0 -1.81 0 mirMAP -0.29 0 NA
68 hsa-miR-30e-5p CPEB3 1.24 0 -1.3 0 mirMAP -0.11 0.01548 NA
69 hsa-miR-30e-5p CPEB4 1.24 0 -1.56 0 mirMAP -0.25 0 NA
70 hsa-miR-30e-5p CPNE8 1.24 0 -1.12 0.00722 MirTarget -0.66 0 NA
71 hsa-miR-30e-5p CSNK1A1 1.24 0 -0.45 0.00045 MirTarget -0.1 0.00069 NA
72 hsa-miR-30e-5p CTHRC1 1.24 0 0.84 0.10163 MirTarget -1.31 0 NA
73 hsa-miR-30e-5p CUX1 1.24 0 -0.4 0.0025 mirMAP -0.14 1.0E-5 NA
74 hsa-miR-30e-5p CYLD 1.24 0 -0.89 0 mirMAP -0.29 0 NA
75 hsa-miR-30e-5p CYP19A1 1.24 0 -1.81 3.0E-5 mirMAP -0.54 0 NA
76 hsa-miR-30e-5p DACT1 1.24 0 -1.78 2.0E-5 MirTarget -1.07 0 NA
77 hsa-miR-30e-5p DDIT4 1.24 0 0.72 0.04305 MirTarget -0.28 0.00076 NA
78 hsa-miR-30e-5p DIO2 1.24 0 -0.24 0.63454 mirMAP -1.1 0 NA
79 hsa-miR-30e-5p DIP2B 1.24 0 0.33 0.05275 MirTarget -0.13 0.00147 NA
80 hsa-miR-30e-5p DNM3 1.24 0 -1.22 4.0E-5 mirMAP -0.32 0 NA
81 hsa-miR-30e-5p DPP8 1.24 0 -0.52 0.02104 mirMAP -0.15 0.00462 NA
82 hsa-miR-30e-5p DPYSL2 1.24 0 -1.76 0 MirTarget; mirMAP; miRNATAP -0.67 0 NA
83 hsa-miR-30e-5p DRP2 1.24 0 -1.35 0.00023 mirMAP -0.64 0 NA
84 hsa-miR-30e-5p DSEL 1.24 0 -1.79 0 mirMAP -0.51 0 NA
85 hsa-miR-30e-5p DSP 1.24 0 1.74 0.00051 MirTarget -0.37 0.00178 NA
86 hsa-miR-30e-5p DSTYK 1.24 0 -0.39 0.00405 MirTarget -0.13 6.0E-5 NA
87 hsa-miR-30e-5p EDNRA 1.24 0 -2.19 0 mirMAP -1.02 0 NA
88 hsa-miR-30e-5p EFR3A 1.24 0 -0.35 0.02542 mirMAP -0.19 0 NA
89 hsa-miR-30e-5p EGR3 1.24 0 -4.25 0 mirMAP -0.99 0 NA
90 hsa-miR-30e-5p EIF2AK2 1.24 0 0.89 1.0E-5 mirMAP -0.13 0.009 NA
91 hsa-miR-30e-5p EIF5A2 1.24 0 -1.12 0.00497 mirMAP -0.82 0 NA
92 hsa-miR-30e-5p ELL2 1.24 0 -1.08 1.0E-5 MirTarget -0.4 0 NA
93 hsa-miR-30e-5p EML1 1.24 0 -2.07 0 MirTarget -0.59 0 NA
94 hsa-miR-30e-5p ENPP1 1.24 0 -2.1 0 mirMAP -0.92 0 NA
95 hsa-miR-30e-5p ENTPD1 1.24 0 -1.12 0 mirMAP -0.44 0 NA
96 hsa-miR-30e-5p EPDR1 1.24 0 -1.64 0.00035 MirTarget -0.78 0 NA
97 hsa-miR-30e-5p ERCC4 1.24 0 -0.28 0.07883 MirTarget -0.16 1.0E-5 NA
98 hsa-miR-30e-5p ERMN 1.24 0 0.44 0.31406 MirTarget -0.47 0 NA
99 hsa-miR-30e-5p ERRFI1 1.24 0 -1.11 0.00014 MirTarget -0.26 0.00014 NA
100 hsa-miR-30e-5p ETF1 1.24 0 -0.75 0 mirMAP -0.19 0 NA
101 hsa-miR-30e-5p ETS2 1.24 0 -1.34 0 mirMAP -0.19 0.00193 NA
102 hsa-miR-30e-5p FAM110B 1.24 0 -2.49 0 MirTarget -0.8 0 NA
103 hsa-miR-30e-5p FAM126A 1.24 0 -0.53 0.10015 mirMAP -0.63 0 NA
104 hsa-miR-30e-5p FAM131B 1.24 0 -1.34 0.00082 MirTarget -0.62 0 NA
105 hsa-miR-30e-5p FAM43A 1.24 0 -1.99 0 MirTarget -0.48 0 NA
106 hsa-miR-30e-5p FAM49A 1.24 0 -1.29 0.0006 MirTarget -0.42 0 NA
107 hsa-miR-30e-5p FAM69A 1.24 0 -0.97 0.00013 MirTarget -0.62 0 NA
108 hsa-miR-30e-5p FEM1B 1.24 0 -0.69 0 mirMAP -0.16 0 NA
109 hsa-miR-30e-5p FGD4 1.24 0 -0.29 0.14334 mirMAP -0.16 0.00037 NA
110 hsa-miR-30e-5p FGD6 1.24 0 0.16 0.53702 MirTarget -0.42 0 NA
111 hsa-miR-30e-5p FGF5 1.24 0 0.3 0.62957 mirMAP -1.16 0 NA
112 hsa-miR-30e-5p FMN1 1.24 0 -0.37 0.4819 mirMAP -0.75 0 NA
113 hsa-miR-30e-5p FNIP2 1.24 0 -0.76 0.01045 MirTarget; mirMAP -0.35 0 NA
114 hsa-miR-30e-5p FOXD1 1.24 0 1.12 0.1219 MirTarget -1.06 0 NA
115 hsa-miR-30e-5p FOXP2 1.24 0 -3.99 0 mirMAP -1.08 0 NA
116 hsa-miR-30e-5p FRMD6 1.24 0 -0.93 0.00183 MirTarget -0.52 0 NA
117 hsa-miR-30e-5p FTO 1.24 0 -0.52 0.0001 mirMAP -0.22 0 NA
118 hsa-miR-30e-5p FUT4 1.24 0 -0.25 0.34769 mirMAP -0.2 0.0015 NA
119 hsa-miR-30e-5p FYCO1 1.24 0 -1.62 0 MirTarget; miRNATAP -0.22 1.0E-5 NA
120 hsa-miR-30e-5p GAB1 1.24 0 -0.89 0 mirMAP -0.14 0.0018 NA
121 hsa-miR-30e-5p GALNT13 1.24 0 -1.81 0.00232 MirTarget -0.45 0.00136 NA
122 hsa-miR-30e-5p GALNT2 1.24 0 0.59 0.00028 MirTarget -0.11 0.00483 NA
123 hsa-miR-30e-5p GFOD1 1.24 0 -0.94 0.00661 mirMAP -0.76 0 NA
124 hsa-miR-30e-5p GFPT2 1.24 0 -2.18 0.00094 MirTarget -1.78 0 NA
125 hsa-miR-30e-5p GJA1 1.24 0 -1.07 0.00282 MirTarget -0.36 2.0E-5 NA
126 hsa-miR-30e-5p GLCE 1.24 0 0.26 0.17205 MirTarget -0.21 0 NA
127 hsa-miR-30e-5p GLI2 1.24 0 -2.29 0 MirTarget -1.24 0 NA
128 hsa-miR-30e-5p GNAI2 1.24 0 -0.22 0.08971 miRNAWalker2 validate; MirTarget; miRNATAP -0.11 0.00017 NA
129 hsa-miR-30e-5p GPCPD1 1.24 0 -0.91 0 MirTarget -0.14 0.00167 NA
130 hsa-miR-30e-5p GRK5 1.24 0 -1.48 0 miRNATAP -0.58 0 NA
131 hsa-miR-30e-5p GRM5 1.24 0 0.91 0.09305 MirTarget -0.34 0.00734 NA
132 hsa-miR-30e-5p GTF2A1 1.24 0 -0.44 0.17776 mirMAP -0.28 0.00022 NA
133 hsa-miR-30e-5p GTF2H1 1.24 0 -0.19 0.10464 MirTarget -0.13 0 NA
134 hsa-miR-30e-5p GULP1 1.24 0 -2.32 0 mirMAP -0.97 0 NA
135 hsa-miR-30e-5p HCFC2 1.24 0 -0.81 0 MirTarget -0.26 0 NA
136 hsa-miR-30e-5p HFE 1.24 0 0.04 0.89191 mirMAP -0.19 0.00975 NA
137 hsa-miR-30e-5p HGF 1.24 0 -2.97 0 mirMAP -1.43 0 NA
138 hsa-miR-30e-5p HIPK3 1.24 0 -1.75 0 mirMAP -0.52 0 NA
139 hsa-miR-30e-5p HIVEP1 1.24 0 -0.61 0.00229 MirTarget -0.31 0 NA
140 hsa-miR-30e-5p HLF 1.24 0 -5.48 0 MirTarget -1.08 0 NA
141 hsa-miR-30e-5p HLX 1.24 0 -0.56 0.02055 MirTarget -0.27 0 NA
142 hsa-miR-30e-5p HMGA2 1.24 0 3.21 0.00037 mirMAP -1.45 0 NA
143 hsa-miR-30e-5p IFFO2 1.24 0 -0.91 0.00201 MirTarget -0.33 0 NA
144 hsa-miR-30e-5p IGF1R 1.24 0 -0.49 0.0461 mirMAP -0.22 8.0E-5 NA
145 hsa-miR-30e-5p IKBIP 1.24 0 0.36 0.05162 MirTarget -0.26 0 NA
146 hsa-miR-30e-5p IL6R 1.24 0 -1.87 0 mirMAP -0.45 0 NA
147 hsa-miR-30e-5p IL6ST 1.24 0 -2.1 2.0E-5 mirMAP -0.8 0 NA
148 hsa-miR-30e-5p INHBA 1.24 0 1.44 0.01419 mirMAP -1.37 0 NA
149 hsa-miR-30e-5p IP6K3 1.24 0 -1.25 0.04397 MirTarget -0.62 2.0E-5 NA
150 hsa-miR-30e-5p IPMK 1.24 0 -0.32 0.41022 mirMAP -0.33 0.00024 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 TISSUE DEVELOPMENT 75 1518 1.302e-13 6.058e-10
2 CELL DEVELOPMENT 71 1426 4.62e-13 1.075e-09
3 REGULATION OF CELL DIFFERENTIATION 71 1492 3.957e-12 6.137e-09
4 REGULATION OF CELLULAR COMPONENT MOVEMENT 45 771 9.965e-11 1.159e-07
5 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 61 1275 1.352e-10 1.258e-07
6 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 72 1672 2.672e-10 2.072e-07
7 MESENCHYME DEVELOPMENT 20 190 1.406e-09 9.345e-07
8 REGULATION OF CELL PROLIFERATION 64 1496 4.096e-09 2.382e-06
9 LOCOMOTION 52 1114 8.508e-09 4.399e-06
10 MESENCHYMAL CELL DIFFERENTIATION 16 134 1.036e-08 4.819e-06
11 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 32 513 1.243e-08 5.192e-06
12 NEUROGENESIS 60 1402 1.339e-08 5.192e-06
13 REGULATION OF CELL DEVELOPMENT 42 836 3.507e-08 1.255e-05
14 PROTEIN PHOSPHORYLATION 45 944 5.157e-08 1.714e-05
15 REGULATION OF NEURON DIFFERENTIATION 32 554 7.462e-08 2.301e-05
16 REGULATION OF PHOSPHORUS METABOLIC PROCESS 64 1618 7.911e-08 2.301e-05
17 POSITIVE REGULATION OF GENE EXPRESSION 67 1733 8.816e-08 2.413e-05
18 POSITIVE REGULATION OF CELL PROLIFERATION 40 814 1.365e-07 3.529e-05
19 INTRACELLULAR SIGNAL TRANSDUCTION 62 1572 1.449e-07 3.549e-05
20 MUSCLE STRUCTURE DEVELOPMENT 27 432 1.705e-07 3.966e-05
21 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 46 1021 1.88e-07 4.165e-05
22 REGULATION OF CELL MORPHOGENESIS 31 552 2.233e-07 4.722e-05
23 STEM CELL DIFFERENTIATION 17 190 2.641e-07 5.12e-05
24 REGULATION OF PROTEIN MODIFICATION PROCESS 65 1710 2.627e-07 5.12e-05
25 POSITIVE REGULATION OF LOCOMOTION 26 420 3.483e-07 6.483e-05
26 EMBRYONIC MORPHOGENESIS 30 539 4.255e-07 7.614e-05
27 PHOSPHORYLATION 51 1228 4.695e-07 8.091e-05
28 CELL PROLIFERATION 34 672 6.472e-07 0.0001076
29 CELLULAR COMPONENT MORPHOGENESIS 41 900 6.912e-07 0.0001109
30 HEART DEVELOPMENT 27 466 7.565e-07 0.0001131
31 HEAD DEVELOPMENT 35 709 7.781e-07 0.0001131
32 REGULATION OF EXTENT OF CELL GROWTH 12 101 7.703e-07 0.0001131
33 EPITHELIUM DEVELOPMENT 42 945 9.532e-07 0.0001344
34 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 58 1517 1.067e-06 0.000146
35 REGULATION OF CELLULAR RESPONSE TO STRESS 34 691 1.212e-06 0.0001548
36 CARDIOVASCULAR SYSTEM DEVELOPMENT 37 788 1.231e-06 0.0001548
37 CIRCULATORY SYSTEM DEVELOPMENT 37 788 1.231e-06 0.0001548
38 CELL MOTILITY 38 835 1.856e-06 0.0002214
39 LOCALIZATION OF CELL 38 835 1.856e-06 0.0002214
40 ORGAN MORPHOGENESIS 38 841 2.199e-06 0.0002412
41 TUBE DEVELOPMENT 29 552 2.12e-06 0.0002412
42 NEURON DIFFERENTIATION 39 874 2.17e-06 0.0002412
43 NEURAL CREST CELL DIFFERENTIATION 10 75 2.229e-06 0.0002412
44 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 69 1977 2.382e-06 0.0002519
45 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 35 750 2.775e-06 0.0002869
46 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 41 957 3.232e-06 0.00032
47 TISSUE MORPHOGENESIS 28 533 3.192e-06 0.00032
48 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 34 724 3.38e-06 0.0003211
49 POSITIVE REGULATION OF CELL DIFFERENTIATION 37 823 3.381e-06 0.0003211
50 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 13 138 3.832e-06 0.0003348
51 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 43 1036 4.101e-06 0.0003348
52 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 60 1656 3.83e-06 0.0003348
53 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 43 1036 4.101e-06 0.0003348
54 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 53 1395 3.964e-06 0.0003348
55 REGULATION OF SYSTEM PROCESS 27 507 3.731e-06 0.0003348
56 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 46 1142 4.09e-06 0.0003348
57 NEURON PROJECTION GUIDANCE 16 205 3.611e-06 0.0003348
58 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 21 337 4.272e-06 0.0003428
59 NEURON PROJECTION DEVELOPMENT 28 545 4.867e-06 0.0003824
60 CELL MORPHOGENESIS INVOLVED IN NEURON DIFFERENTIATION 22 368 4.931e-06 0.0003824
61 NEGATIVE REGULATION OF CELL DEATH 38 872 5.116e-06 0.0003839
62 CENTRAL NERVOUS SYSTEM DEVELOPMENT 38 872 5.116e-06 0.0003839
63 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 34 740 5.408e-06 0.0003994
64 NEURON PROJECTION MORPHOGENESIS 23 402 6.209e-06 0.0004514
65 SYNAPSE ORGANIZATION 13 145 6.624e-06 0.0004742
66 REGULATION OF AXONOGENESIS 14 168 6.905e-06 0.0004868
67 REGULATION OF NEURON PROJECTION DEVELOPMENT 23 408 7.905e-06 0.000549
68 CONNECTIVE TISSUE DEVELOPMENT 15 194 8.137e-06 0.0005568
69 REGULATION OF CELL DEATH 54 1472 8.771e-06 0.000583
70 REGULATION OF MUSCLE SYSTEM PROCESS 15 195 8.658e-06 0.000583
71 EMBRYO DEVELOPMENT 38 894 9.031e-06 0.0005918
72 REGULATION OF ANATOMICAL STRUCTURE SIZE 25 472 9.407e-06 0.0006079
73 REGULATION OF AXON GUIDANCE 7 39 1.024e-05 0.0006527
74 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 35 799 1.099e-05 0.0006909
75 FORMATION OF PRIMARY GERM LAYER 11 110 1.206e-05 0.0007338
76 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 541 1.214e-05 0.0007338
77 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 27 541 1.214e-05 0.0007338
78 ACTIN FILAMENT BASED PROCESS 24 450 1.267e-05 0.0007559
79 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 54 1492 1.285e-05 0.0007567
80 POSITIVE REGULATION OF CELL COMMUNICATION 55 1532 1.333e-05 0.000775
81 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 62 1805 1.389e-05 0.0007979
82 REGULATION OF CHEMOTAXIS 14 180 1.52e-05 0.0008626
83 REGULATION OF EPITHELIAL CELL PROLIFERATION 18 285 1.726e-05 0.0009614
84 CELLULAR RESPONSE TO HORMONE STIMULUS 27 552 1.736e-05 0.0009614
85 RESPONSE TO EXTERNAL STIMULUS 62 1821 1.818e-05 0.0009953
86 REGULATION OF CALCIUM ION TRANSPORT 15 209 1.979e-05 0.001071
87 REGULATION OF DEVELOPMENTAL GROWTH 18 289 2.08e-05 0.001097
88 TAXIS 24 464 2.09e-05 0.001097
89 REGULATION OF CELL PROJECTION ORGANIZATION 27 558 2.099e-05 0.001097
90 POSITIVE REGULATION OF OSTEOBLAST DIFFERENTIATION 8 60 2.332e-05 0.001206
91 REGULATION OF MAPK CASCADE 30 660 2.398e-05 0.001226
92 CELL PROJECTION ORGANIZATION 37 902 2.577e-05 0.001303
93 TUBE MORPHOGENESIS 19 323 2.723e-05 0.001362
94 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 62 1848 2.831e-05 0.001402
95 PEPTIDYL AMINO ACID MODIFICATION 35 841 3.199e-05 0.001567
96 MULTICELLULAR ORGANISMAL SIGNALING 11 123 3.463e-05 0.001661
97 REGULATION OF ACTIN FILAMENT BASED MOVEMENT 6 32 3.448e-05 0.001661
98 NEGATIVE REGULATION OF CELL DIFFERENTIATION 28 609 3.676e-05 0.001746
99 MUSCLE TISSUE DEVELOPMENT 17 275 3.864e-05 0.001816
100 REGULATION OF CELL SIZE 13 172 4.12e-05 0.0019
101 DEVELOPMENTAL GROWTH 19 333 4.125e-05 0.0019
102 POSITIVE REGULATION OF NEURON DIFFERENTIATION 18 306 4.416e-05 0.002015
103 ACTIN FILAMENT ORGANIZATION 13 174 4.646e-05 0.002099
104 CELLULAR RESPONSE TO LIPID 23 457 4.732e-05 0.002117
105 REGULATION OF CELLULAR COMPONENT SIZE 19 337 4.845e-05 0.002147
106 NEURON DEVELOPMENT 30 687 5.022e-05 0.002204
107 NEGATIVE REGULATION OF GENE EXPRESSION 52 1493 5.232e-05 0.002275
108 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 30 689 5.294e-05 0.002281
109 POSITIVE REGULATION OF RESPONSE TO STIMULUS 63 1929 5.388e-05 0.002295
110 TELENCEPHALON DEVELOPMENT 15 228 5.425e-05 0.002295
111 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 39 1008 5.592e-05 0.002344
112 NLS BEARING PROTEIN IMPORT INTO NUCLEUS 5 22 5.989e-05 0.002488
113 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 24 498 6.424e-05 0.002622
114 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 21 404 6.374e-05 0.002622
115 NEGATIVE REGULATION OF DEVELOPMENTAL PROCESS 33 801 6.568e-05 0.002657
116 REGULATION OF RESPONSE TO STRESS 51 1468 6.63e-05 0.00266
117 NEURON MIGRATION 10 110 6.815e-05 0.002673
118 EMBRYONIC ORGAN DEVELOPMENT 21 406 6.837e-05 0.002673
119 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 59 1784 6.803e-05 0.002673
120 SEMAPHORIN PLEXIN SIGNALING PATHWAY 6 36 6.93e-05 0.002687
121 POSITIVE REGULATION OF CELL DEVELOPMENT 23 472 7.717e-05 0.002968
122 GROWTH 21 410 7.855e-05 0.002972
123 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 42 1135 7.84e-05 0.002972
124 REGULATION OF KINASE ACTIVITY 32 776 8.338e-05 0.003129
125 CELLULAR RESPONSE TO STRESS 53 1565 9.127e-05 0.003397
126 CIRCADIAN RHYTHM 11 137 9.293e-05 0.003432
127 FOREBRAIN DEVELOPMENT 19 357 0.000104 0.003811
128 REGULATION OF CALCIUM ION TRANSMEMBRANE TRANSPORT 10 116 0.0001067 0.003879
129 POSITIVE REGULATION OF CELLULAR COMPONENT ORGANIZATION 42 1152 0.0001088 0.003923
130 NEGATIVE REGULATION OF PHOSPHORYLATION 21 422 0.0001176 0.004211
131 POSITIVE REGULATION OF FATTY ACID OXIDATION 4 14 0.0001307 0.004644
132 GLAND DEVELOPMENT 20 395 0.0001352 0.004764
133 REGULATION OF ION TRANSPORT 26 592 0.0001456 0.005095
134 LUNG ALVEOLUS DEVELOPMENT 6 41 0.0001471 0.005109
135 EMBRYONIC ORGAN MORPHOGENESIS 16 279 0.0001557 0.005323
136 LIPID PHOSPHORYLATION 9 99 0.0001567 0.005323
137 EPITHELIAL CELL DIFFERENTIATION 23 495 0.000156 0.005323
138 MORPHOGENESIS OF AN EPITHELIUM 20 400 0.0001598 0.005388
139 REGULATION OF STRESS ACTIVATED PROTEIN KINASE SIGNALING CASCADE 13 197 0.0001637 0.005441
140 RESPIRATORY SYSTEM DEVELOPMENT 13 197 0.0001637 0.005441
141 REGULATION OF CARDIAC MUSCLE CELL CONTRACTION 5 27 0.0001692 0.005545
142 MOTOR NEURON AXON GUIDANCE 5 27 0.0001692 0.005545
143 CELL PART MORPHOGENESIS 27 633 0.0001749 0.005653
144 REGULATION OF MUSCLE CONTRACTION 11 147 0.0001741 0.005653
145 REGULATION OF ACTIN FILAMENT BASED PROCESS 17 312 0.0001806 0.005754
146 CHONDROCYTE DIFFERENTIATION 7 60 0.0001798 0.005754
147 PEPTIDYL SERINE MODIFICATION 11 148 0.0001848 0.005848
148 POSITIVE REGULATION OF MAPK CASCADE 22 470 0.0001948 0.006084
149 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 22 470 0.0001948 0.006084
150 MEMBRANE DEPOLARIZATION 7 61 0.0001997 0.006194
151 REGULATION OF CIRCADIAN RHYTHM 9 103 0.000212 0.006532
152 REGULATION OF MUSCLE ADAPTATION 7 63 0.0002448 0.007494
153 AMEBOIDAL TYPE CELL MIGRATION 11 154 0.0002613 0.00794
154 POSITIVE REGULATION OF OSSIFICATION 8 84 0.0002628 0.00794
155 GASTRULATION 11 155 0.0002764 0.008297
156 PEPTIDYL THREONINE MODIFICATION 6 46 0.000282 0.008385
157 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 46 1360 0.0002829 0.008385
158 REGULATION OF METAL ION TRANSPORT 17 325 0.0002914 0.008541
159 MUSCLE CELL DIFFERENTIATION 14 237 0.0002937 0.008541
160 REGULATION OF BLOOD CIRCULATION 16 295 0.0002923 0.008541
161 EYE DEVELOPMENT 17 326 0.000302 0.008673
162 REGULATION OF TRANSPORT 57 1804 0.0003011 0.008673
163 NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 36 983 0.0003146 0.00898
164 MESODERM MORPHOGENESIS 7 66 0.0003275 0.009235
165 RHYTHMIC PROCESS 16 298 0.0003271 0.009235
166 REGULATION OF CELL GROWTH 19 391 0.0003315 0.009291
167 REGULATION OF CARBOHYDRATE BIOSYNTHETIC PROCESS 8 87 0.0003346 0.009322
168 REGULATION OF CATABOLIC PROCESS 29 731 0.000341 0.009388
169 UROGENITAL SYSTEM DEVELOPMENT 16 299 0.0003395 0.009388
170 PEPTIDYL TYROSINE MODIFICATION 12 186 0.0003562 0.00975
171 REGULATION OF STEM CELL PROLIFERATION 8 88 0.0003618 0.00982
172 REGULATION OF TRANSMEMBRANE TRANSPORT 20 426 0.000363 0.00982
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 45 842 1.646e-09 1.529e-06
2 PROTEIN KINASE ACTIVITY 36 640 2.169e-08 1.007e-05
3 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 46 992 8.163e-08 2.528e-05
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 328 7.478e-07 0.0001737
5 RIBONUCLEOTIDE BINDING 67 1860 1.154e-06 0.0002144
6 ENZYME BINDING 63 1737 2.035e-06 0.0003151
7 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 31 629 3.519e-06 0.000467
8 CYTOSKELETAL PROTEIN BINDING 36 819 7.592e-06 0.0008816
9 MACROMOLECULAR COMPLEX BINDING 52 1399 9.134e-06 0.0009428
10 SH3 DOMAIN BINDING 11 116 1.999e-05 0.001857
11 KINASE BINDING 28 606 3.37e-05 0.002609
12 PROTEIN SERINE THREONINE KINASE ACTIVITY 23 445 3.14e-05 0.002609
13 ACTIN BINDING 21 393 4.29e-05 0.003066
14 PROTEIN KINASE C BINDING 7 50 5.512e-05 0.003201
15 PROTEIN TYROSINE KINASE ACTIVITY 13 176 5.229e-05 0.003201
16 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 15 226 4.906e-05 0.003201
17 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 18 315 6.422e-05 0.003509
18 ADENYL NUCLEOTIDE BINDING 52 1514 7.492e-05 0.003867
19 TRANSCRIPTIONAL REPRESSOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 12 168 0.0001387 0.006774
20 RECEPTOR BINDING 50 1476 0.0001458 0.006774
21 REGULATORY REGION NUCLEIC ACID BINDING 32 818 0.0002172 0.009608
NumGOOverlapSizeP ValueAdj. P Value
1 NEURON PROJECTION 43 942 3.431e-07 0.0001002
2 CELL PROJECTION 67 1786 2.694e-07 0.0001002
3 CYTOSKELETON 69 1967 1.993e-06 0.0003642
4 SOMATODENDRITIC COMPARTMENT 32 650 2.495e-06 0.0003642
5 SYNAPSE 35 754 3.122e-06 0.0003647
6 NEURON PART 48 1265 1.226e-05 0.001193
7 PERINUCLEAR REGION OF CYTOPLASM 29 642 3.674e-05 0.003065
8 CELL BODY 24 494 5.665e-05 0.004136
9 AXON 21 418 0.000103 0.006336
10 DENDRITE 22 451 0.0001085 0.006336

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 cGMP_PKG_signaling_pathway_hsa04022 14 163 4.861e-06 0.0002528
2 Oocyte_meiosis_hsa04114 11 124 3.734e-05 0.0007611
3 cAMP_signaling_pathway_hsa04024 14 198 4.391e-05 0.0007611
4 Ras_signaling_pathway_hsa04014 15 232 6.61e-05 0.0008593
5 PI3K_Akt_signaling_pathway_hsa04151 19 352 8.647e-05 0.0008993
6 mTOR_signaling_pathway_hsa04150 11 151 0.0002202 0.0019
7 ErbB_signaling_pathway_hsa04012 8 85 0.0002852 0.0019
8 MAPK_signaling_pathway_hsa04010 16 295 0.0002923 0.0019
9 Autophagy_animal_hsa04140 9 128 0.001044 0.006034
10 FoxO_signaling_pathway_hsa04068 9 132 0.001297 0.006746
11 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 9 139 0.001857 0.008779
12 Sphingolipid_signaling_pathway_hsa04071 8 118 0.002465 0.01068
13 AMPK_signaling_pathway_hsa04152 8 121 0.002881 0.01152
14 Calcium_signaling_pathway_hsa04020 9 182 0.01071 0.03978
15 HIF_1_signaling_pathway_hsa04066 6 100 0.01472 0.05104
16 Focal_adhesion_hsa04510 9 199 0.01823 0.05926
17 Gap_junction_hsa04540 5 88 0.03084 0.09432
18 Cellular_senescence_hsa04218 7 160 0.04084 0.118
19 Phosphatidylinositol_signaling_system_hsa04070 5 99 0.04735 0.1296
20 Rap1_signaling_pathway_hsa04015 8 206 0.05382 0.1382
21 Apelin_signaling_pathway_hsa04371 6 137 0.05581 0.1382
22 Phospholipase_D_signaling_pathway_hsa04072 6 146 0.07129 0.1685
23 TGF_beta_signaling_pathway_hsa04350 4 84 0.086 0.1944
24 Cytokine_cytokine_receptor_interaction_hsa04060 9 270 0.09057 0.1962
25 Cell_cycle_hsa04110 5 124 0.1011 0.2088
26 Necroptosis_hsa04217 6 164 0.1089 0.2088
27 VEGF_signaling_pathway_hsa04370 3 59 0.1123 0.2088
28 Hippo_signaling_pathway_multiple_species_hsa04392 2 29 0.1124 0.2088
29 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.1213 0.2176
30 Wnt_signaling_pathway_hsa04310 5 146 0.1654 0.2794
31 TNF_signaling_pathway_hsa04668 4 108 0.1676 0.2794
32 Adherens_junction_hsa04520 3 72 0.1719 0.2794
33 Hippo_signaling_pathway_hsa04390 5 154 0.1921 0.3027
34 Hedgehog_signaling_pathway_hsa04340 2 47 0.2393 0.366
35 Tight_junction_hsa04530 5 170 0.2494 0.3705
36 Cell_adhesion_molecules_.CAMs._hsa04514 4 145 0.3251 0.4696
37 Endocytosis_hsa04144 6 244 0.3561 0.5005
38 Mitophagy_animal_hsa04137 2 65 0.3709 0.5076
39 p53_signaling_pathway_hsa04115 2 68 0.3921 0.5221
40 Jak_STAT_signaling_pathway_hsa04630 4 162 0.4016 0.5221
41 Neuroactive_ligand_receptor_interaction_hsa04080 6 278 0.4757 0.5882
42 ECM_receptor_interaction_hsa04512 2 82 0.4864 0.5882
43 Apoptosis_hsa04210 3 138 0.5184 0.6126
44 Phagosome_hsa04145 3 152 0.5838 0.658

Quest ID: 17a19a96a902da3e50aab5452e59e85d