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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-181b-5p ABI3BP 2.49 0 -4.28 0 miRNATAP -0.74 0 NA
2 hsa-miR-181b-5p ACSL1 2.49 0 -0 0.993 MirTarget -0.12 0.00517 NA
3 hsa-miR-181b-5p ACSS3 2.49 0 -2.48 1.0E-5 MirTarget -0.25 0.01051 NA
4 hsa-miR-181b-5p ADAMTS1 2.49 0 -3.81 0 miRNATAP -0.53 0 NA
5 hsa-miR-181b-5p ADAMTS18 2.49 0 -0.74 0.14599 miRNATAP -0.17 0.04646 NA
6 hsa-miR-181b-5p ADAMTS5 2.49 0 -2.16 0 mirMAP; miRNATAP -0.25 1.0E-5 NA
7 hsa-miR-181b-5p ADAMTS6 2.49 0 -0.88 0.01914 miRNATAP -0.13 0.03705 NA
8 hsa-miR-181b-5p ADAMTSL1 2.49 0 -2.52 0 miRNATAP -0.35 1.0E-5 NA
9 hsa-miR-181b-5p ADARB1 2.49 0 -1.93 0 MirTarget; miRNATAP -0.36 0 NA
10 hsa-miR-181b-5p ADCY9 2.49 0 -1.5 0 miRNATAP -0.24 0 24269684 miR 181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 AC9 in cervical cancer cells; Phenotypic experiments indicated that miR-181b and AC9 exerted opposite effects on cell proliferation and apoptosis
11 hsa-miR-181b-5p AFF1 2.49 0 -0.53 0.00163 mirMAP; miRNATAP -0.11 0.00021 NA
12 hsa-miR-181b-5p AFF4 2.49 0 -0.82 0 mirMAP; miRNATAP -0.12 0 NA
13 hsa-miR-181b-5p AGFG2 2.49 0 -0.51 0.00539 mirMAP -0.11 0.00068 NA
14 hsa-miR-181b-5p AKT3 2.49 0 -1.94 0 miRNATAP -0.27 1.0E-5 NA
15 hsa-miR-181b-5p ANKRD12 2.49 0 -0.64 0.00012 mirMAP -0.12 1.0E-5 NA
16 hsa-miR-181b-5p ANTXR2 2.49 0 -2.31 0 mirMAP -0.41 0 NA
17 hsa-miR-181b-5p ANXA11 2.49 0 -0.43 0.01849 MirTarget; mirMAP -0.13 1.0E-5 NA
18 hsa-miR-181b-5p AR 2.49 0 -3.3 0 miRNATAP -0.48 3.0E-5 NA
19 hsa-miR-181b-5p ARHGAP5 2.49 0 -0.63 0.00047 mirMAP -0.13 3.0E-5 NA
20 hsa-miR-181b-5p ARHGEF3 2.49 0 -0.76 0 MirTarget -0.12 3.0E-5 NA
21 hsa-miR-181b-5p ARNT2 2.49 0 -1.45 0.00019 miRNATAP -0.23 0.00069 NA
22 hsa-miR-181b-5p ARRDC3 2.49 0 -0.71 0.00062 MirTarget; mirMAP; miRNATAP -0.13 0.00027 NA
23 hsa-miR-181b-5p ARRDC4 2.49 0 -1.43 0 miRNATAP -0.24 0 NA
24 hsa-miR-181b-5p ARSJ 2.49 0 -1.58 0.00066 MirTarget; miRNATAP -0.21 0.0097 NA
25 hsa-miR-181b-5p ASPA 2.49 0 -4.76 0 mirMAP -0.33 0.00104 NA
26 hsa-miR-181b-5p ASXL2 2.49 0 -0.51 0.09339 mirMAP -0.17 0.00114 NA
27 hsa-miR-181b-5p ATE1 2.49 0 -1.09 3.0E-5 mirMAP -0.24 0 NA
28 hsa-miR-181b-5p ATF2 2.49 0 -0.36 0.09137 mirMAP; miRNATAP -0.1 0.00428 NA
29 hsa-miR-181b-5p ATM 2.49 0 -0.69 1.0E-5 MirTarget -0.11 8.0E-5 21102523; 23656790 Ataxia telangiectasia mutated ATM a target gene of miR-181 exhibited reduced expression in mammospheres and upon TGF-β treatment;We report that miR-181a and miR-181b were overexpressed in more aggressive breast cancers and their expression correlates inversely with ATM levels
30 hsa-miR-181b-5p ATP8A1 2.49 0 -1.48 8.0E-5 MirTarget; miRNATAP -0.33 0 NA
31 hsa-miR-181b-5p ATP8B1 2.49 0 -0.4 0.21267 miRNATAP -0.13 0.02306 NA
32 hsa-miR-181b-5p ATXN1 2.49 0 -1.51 0 miRNATAP -0.2 2.0E-5 NA
33 hsa-miR-181b-5p BCL2 2.49 0 -2.02 0 miRNAWalker2 validate; miRTarBase -0.31 0 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression
34 hsa-miR-181b-5p BCL6 2.49 0 -0.56 0.00743 miRNATAP -0.22 0 NA
35 hsa-miR-181b-5p BCL6B 2.49 0 -1.06 7.0E-5 MirTarget -0.1 0.02719 NA
36 hsa-miR-181b-5p BHLHE40 2.49 0 -0.75 0.00869 MirTarget; miRNATAP -0.11 0.03027 NA
37 hsa-miR-181b-5p BMPR2 2.49 0 -0.59 4.0E-5 miRNATAP -0.12 0 NA
38 hsa-miR-181b-5p BNC2 2.49 0 -2.95 0 miRNATAP -0.51 0 NA
39 hsa-miR-181b-5p C14orf132 2.49 0 -1.97 0 mirMAP -0.29 4.0E-5 NA
40 hsa-miR-181b-5p C15orf52 2.49 0 -1.18 0.0026 mirMAP -0.25 0.00018 NA
41 hsa-miR-181b-5p C2orf88 2.49 0 -2.14 0 mirMAP -0.26 1.0E-5 NA
42 hsa-miR-181b-5p CACNA2D1 2.49 0 -3.32 0 mirMAP -0.74 0 NA
43 hsa-miR-181b-5p CACNB2 2.49 0 -2.97 0 miRNATAP -0.64 0 NA
44 hsa-miR-181b-5p CACNB4 2.49 0 -2.87 0 mirMAP -0.6 0 NA
45 hsa-miR-181b-5p CALCRL 2.49 0 -0.67 0.01537 MirTarget -0.22 0 NA
46 hsa-miR-181b-5p CALM1 2.49 0 -0.54 1.0E-5 miRNATAP -0.11 0 NA
47 hsa-miR-181b-5p CAMK2G 2.49 0 -0.52 0.0078 miRNATAP -0.21 0 NA
48 hsa-miR-181b-5p CAPZA2 2.49 0 -0.83 0 mirMAP -0.15 0 NA
49 hsa-miR-181b-5p CBX7 2.49 0 -2.55 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.51 0 NA
50 hsa-miR-181b-5p CCDC141 2.49 0 -2.94 0 mirMAP -0.34 0 NA
51 hsa-miR-181b-5p CCDC6 2.49 0 -0.27 0.05122 mirMAP; miRNATAP -0.14 0 NA
52 hsa-miR-181b-5p CCDC85A 2.49 0 -1.95 0 mirMAP; miRNATAP -0.18 0.0091 NA
53 hsa-miR-181b-5p CD69 2.49 0 -2.49 0 miRNATAP -0.18 0.03725 NA
54 hsa-miR-181b-5p CDC42BPA 2.49 0 -1.41 0 MirTarget; miRNATAP -0.25 0 NA
55 hsa-miR-181b-5p CDON 2.49 0 -2.61 0 MirTarget -0.41 0 NA
56 hsa-miR-181b-5p CHIC1 2.49 0 -1.03 0 mirMAP -0.11 0.00065 NA
57 hsa-miR-181b-5p CHL1 2.49 0 -2.42 0.00043 MirTarget -0.38 0.0012 NA
58 hsa-miR-181b-5p CLIP1 2.49 0 -0.85 0 MirTarget; miRNATAP -0.22 0 NA
59 hsa-miR-181b-5p CLOCK 2.49 0 -0.51 0.03689 mirMAP -0.16 7.0E-5 NA
60 hsa-miR-181b-5p CNKSR2 2.49 0 -2.85 0 MirTarget; miRNATAP -0.47 0 NA
61 hsa-miR-181b-5p CNKSR3 2.49 0 -1.81 0 MirTarget -0.23 1.0E-5 NA
62 hsa-miR-181b-5p CNR1 2.49 0 -2.44 4.0E-5 mirMAP -0.31 0.00244 NA
63 hsa-miR-181b-5p CNST 2.49 0 -0.93 0 mirMAP -0.15 0 NA
64 hsa-miR-181b-5p CNTN4 2.49 0 -3.06 0 miRNATAP -0.43 0 NA
65 hsa-miR-181b-5p COBL 2.49 0 -2.83 2.0E-5 mirMAP -0.39 0.00061 NA
66 hsa-miR-181b-5p CORO1C 2.49 0 -1.12 0 mirMAP -0.14 0.00018 NA
67 hsa-miR-181b-5p CPEB4 2.49 0 -1.56 0 miRNATAP -0.31 0 NA
68 hsa-miR-181b-5p CREB3L2 2.49 0 -0.29 0.1662 mirMAP -0.11 0.00195 NA
69 hsa-miR-181b-5p CREBL2 2.49 0 -0.7 0 MirTarget -0.11 0 NA
70 hsa-miR-181b-5p CSF2RB 2.49 0 -0.74 0.0696 MirTarget -0.2 0.00405 NA
71 hsa-miR-181b-5p CSGALNACT1 2.49 0 -2.42 0 mirMAP -0.35 0 NA
72 hsa-miR-181b-5p CTDSPL 2.49 0 -0.64 0.00013 MirTarget; miRNATAP -0.13 1.0E-5 NA
73 hsa-miR-181b-5p CTTNBP2 2.49 0 -2.9 1.0E-5 miRNATAP -0.26 0.01704 NA
74 hsa-miR-181b-5p CYP4F3 2.49 0 -0.23 0.75849 mirMAP -0.43 0.00055 NA
75 hsa-miR-181b-5p CYR61 2.49 0 -3.32 0 miRNATAP -0.3 1.0E-5 NA
76 hsa-miR-181b-5p DAAM1 2.49 0 -0.94 0.00028 mirMAP -0.2 1.0E-5 NA
77 hsa-miR-181b-5p DCN 2.49 0 -3.45 0 MirTarget -0.58 0 NA
78 hsa-miR-181b-5p DDX3X 2.49 0 -0.81 0 miRNATAP -0.1 0 NA
79 hsa-miR-181b-5p DENND5B 2.49 0 -1.35 0.0001 MirTarget; mirMAP -0.12 0.04194 NA
80 hsa-miR-181b-5p DGKB 2.49 0 -4.24 0 mirMAP -0.9 0 NA
81 hsa-miR-181b-5p DGKH 2.49 0 -0.51 0.06243 MirTarget -0.16 0.00041 NA
82 hsa-miR-181b-5p DGKI 2.49 0 -0.2 0.6008 mirMAP -0.23 0.00056 NA
83 hsa-miR-181b-5p DIP2C 2.49 0 -1.11 0 MirTarget; miRNATAP -0.18 0 NA
84 hsa-miR-181b-5p DIXDC1 2.49 0 -3.01 0 mirMAP -0.49 0 NA
85 hsa-miR-181b-5p DLC1 2.49 0 -1.8 0 mirMAP -0.12 0.01712 NA
86 hsa-miR-181b-5p DNAJC27 2.49 0 -0.9 0 mirMAP -0.14 0 NA
87 hsa-miR-181b-5p DPYSL2 2.49 0 -1.76 0 MirTarget; miRNATAP -0.24 0 NA
88 hsa-miR-181b-5p DSEL 2.49 0 -1.79 0 mirMAP -0.16 0.00714 NA
89 hsa-miR-181b-5p DTNA 2.49 0 -4.06 0 mirMAP -0.74 0 NA
90 hsa-miR-181b-5p EDNRA 2.49 0 -2.19 0 mirMAP -0.29 0 NA
91 hsa-miR-181b-5p EEA1 2.49 0 -0.49 0.00741 mirMAP -0.15 0 NA
92 hsa-miR-181b-5p EGLN1 2.49 0 -0.39 0.0025 mirMAP -0.11 0 NA
93 hsa-miR-181b-5p EGR1 2.49 0 -3.5 0 miRNATAP -0.3 1.0E-5 NA
94 hsa-miR-181b-5p EGR3 2.49 0 -4.25 0 mirMAP -0.38 0 NA
95 hsa-miR-181b-5p ELOVL2 2.49 0 -1.4 0.00118 miRNATAP -0.29 7.0E-5 NA
96 hsa-miR-181b-5p ENAH 2.49 0 -0.68 0.00063 miRNATAP -0.13 0.00011 NA
97 hsa-miR-181b-5p EPHA3 2.49 0 -3.18 0 mirMAP -0.51 0 NA
98 hsa-miR-181b-5p ERG 2.49 0 -1.35 0 mirMAP; miRNATAP -0.21 0 NA
99 hsa-miR-181b-5p ESR1 2.49 0 -2.87 0 miRNATAP -0.35 1.0E-5 NA
100 hsa-miR-181b-5p ETF1 2.49 0 -0.75 0 miRNATAP -0.1 0 NA
101 hsa-miR-181b-5p EXOC6B 2.49 0 -0.48 0.11834 mirMAP -0.13 0.01159 NA
102 hsa-miR-181b-5p FAM102A 2.49 0 -0.85 0 miRNATAP -0.11 0.00033 NA
103 hsa-miR-181b-5p FAM102B 2.49 0 -1.36 0 MirTarget; mirMAP -0.16 9.0E-5 NA
104 hsa-miR-181b-5p FAM179B 2.49 0 -0.42 0.00497 miRNATAP -0.1 7.0E-5 NA
105 hsa-miR-181b-5p FAM26E 2.49 0 -1.51 4.0E-5 mirMAP -0.19 0.0033 NA
106 hsa-miR-181b-5p FAM46A 2.49 0 -1.54 0 mirMAP; miRNATAP -0.14 0.00041 NA
107 hsa-miR-181b-5p FAM63B 2.49 0 -0.55 0.03992 mirMAP -0.22 0 NA
108 hsa-miR-181b-5p FAT3 2.49 0 -2.79 0 miRNATAP -0.53 0 NA
109 hsa-miR-181b-5p FBXO32 2.49 0 -0.93 0.00122 mirMAP -0.22 0 NA
110 hsa-miR-181b-5p FGF2 2.49 0 -3.46 0 mirMAP -0.49 0 NA
111 hsa-miR-181b-5p FGF9 2.49 0 -4.26 0 mirMAP -0.51 0 NA
112 hsa-miR-181b-5p FGFR1 2.49 0 -2.88 0 miRNAWalker2 validate -0.3 1.0E-5 NA
113 hsa-miR-181b-5p FOS 2.49 0 -3.4 0 miRNATAP -0.35 0 NA
114 hsa-miR-181b-5p FOXP1 2.49 0 -0.87 0 MirTarget; miRNATAP -0.16 0 NA
115 hsa-miR-181b-5p FOXP2 2.49 0 -3.99 0 mirMAP -0.63 0 NA
116 hsa-miR-181b-5p FREM1 2.49 0 -3.1 0 mirMAP -0.3 0.00376 NA
117 hsa-miR-181b-5p FSTL1 2.49 0 -1.2 3.0E-5 mirMAP -0.17 0.0008 NA
118 hsa-miR-181b-5p GAB2 2.49 0 -1.2 0 mirMAP -0.11 0.00994 NA
119 hsa-miR-181b-5p GAN 2.49 0 -0.44 0.10306 mirMAP -0.15 0.00161 NA
120 hsa-miR-181b-5p GAPT 2.49 0 -1.64 0.00011 MirTarget -0.3 4.0E-5 NA
121 hsa-miR-181b-5p GATA6 2.49 0 -3.38 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.44 0 25872572 Hypoxia induced miR 181b enhances angiogenesis of retinoblastoma cells by targeting PDCD10 and GATA6; Additionally miR-181b exerts its angiogenic function at least in part by inhibiting PDCD10 and GATA6
122 hsa-miR-181b-5p GATM 2.49 0 -1.38 0.00867 MirTarget -0.29 0.00111 NA
123 hsa-miR-181b-5p GFOD1 2.49 0 -0.94 0.00661 mirMAP -0.17 0.00354 NA
124 hsa-miR-181b-5p GFRA1 2.49 0 -5 0 mirMAP -0.7 0 NA
125 hsa-miR-181b-5p GLP2R 2.49 0 -5.64 0 mirMAP -0.91 0 NA
126 hsa-miR-181b-5p GPCPD1 2.49 0 -0.91 0 MirTarget; miRNATAP -0.11 0.00045 NA
127 hsa-miR-181b-5p GPD1L 2.49 0 -1.18 0.00027 MirTarget; miRNATAP -0.28 0 NA
128 hsa-miR-181b-5p GRB10 2.49 0 -1.4 0 miRNATAP -0.13 0.01025 NA
129 hsa-miR-181b-5p GULP1 2.49 0 -2.32 0 mirMAP -0.28 5.0E-5 NA
130 hsa-miR-181b-5p HAND2 2.49 0 -4.39 0 miRNATAP -0.81 0 NA
131 hsa-miR-181b-5p HEG1 2.49 0 -0.95 0.00135 mirMAP -0.12 0.01526 NA
132 hsa-miR-181b-5p HEY2 2.49 0 -0.86 0.00087 miRNATAP -0.12 0.00833 NA
133 hsa-miR-181b-5p HGF 2.49 0 -2.97 0 mirMAP -0.71 0 NA
134 hsa-miR-181b-5p HHIPL1 2.49 0 -0.82 0.03102 mirMAP -0.17 0.00807 NA
135 hsa-miR-181b-5p HIPK1 2.49 0 -0.59 4.0E-5 mirMAP -0.13 0 NA
136 hsa-miR-181b-5p HIPK3 2.49 0 -1.75 0 MirTarget; mirMAP -0.36 0 NA
137 hsa-miR-181b-5p HLF 2.49 0 -5.48 0 MirTarget; miRNATAP -0.87 0 NA
138 hsa-miR-181b-5p HOXA11 2.49 0 -0.78 0.02922 miRNATAP -0.13 0.03379 NA
139 hsa-miR-181b-5p IGF1 2.49 0 -3.76 0 mirMAP -0.7 0 NA
140 hsa-miR-181b-5p IL1R1 2.49 0 -0.75 0.00819 mirMAP -0.14 0.00312 NA
141 hsa-miR-181b-5p IL6ST 2.49 0 -2.1 2.0E-5 mirMAP -0.5 0 NA
142 hsa-miR-181b-5p INPP5A 2.49 0 -1.2 0 MirTarget; miRNATAP -0.18 0 NA
143 hsa-miR-181b-5p IPMK 2.49 0 -0.32 0.41022 MirTarget; miRNATAP -0.18 0.00695 NA
144 hsa-miR-181b-5p IPO7 2.49 0 -0.64 7.0E-5 MirTarget -0.12 2.0E-5 NA
145 hsa-miR-181b-5p IPO8 2.49 0 -0.46 0.00011 MirTarget; miRNATAP -0.11 0 NA
146 hsa-miR-181b-5p IQGAP2 2.49 0 -1.52 3.0E-5 miRNATAP -0.19 0.00233 NA
147 hsa-miR-181b-5p IRS2 2.49 0 -0.91 0.01102 MirTarget; miRNATAP -0.19 0.00199 NA
148 hsa-miR-181b-5p ITGA1 2.49 0 -1.43 0 mirMAP -0.29 0 NA
149 hsa-miR-181b-5p ITGA9 2.49 0 -2.58 0 mirMAP -0.26 0.00017 NA
150 hsa-miR-181b-5p ITIH5 2.49 0 -4.03 0 mirMAP -0.62 0 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 REGULATION OF CELL DIFFERENTIATION 70 1492 3.246e-12 7.552e-09
2 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 79 1784 1.879e-12 7.552e-09
3 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 74 1672 1.144e-11 1.774e-08
4 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 55 1142 3.767e-10 3.635e-07
5 TISSUE DEVELOPMENT 66 1518 3.906e-10 3.635e-07
6 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 50 1008 9.745e-10 7.557e-07
7 REGULATION OF CELL DEVELOPMENT 44 836 1.831e-09 1.217e-06
8 RESPONSE TO ENDOGENOUS STIMULUS 62 1450 2.787e-09 1.621e-06
9 REGULATION OF PHOSPHORUS METABOLIC PROCESS 66 1618 5.203e-09 2.69e-06
10 CARDIOVASCULAR SYSTEM DEVELOPMENT 41 788 9.478e-09 4.009e-06
11 CIRCULATORY SYSTEM DEVELOPMENT 41 788 9.478e-09 4.009e-06
12 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 59 1395 1.068e-08 4.142e-06
13 REGULATION OF NEURON DIFFERENTIATION 33 554 1.198e-08 4.287e-06
14 POSITIVE REGULATION OF CELL COMMUNICATION 62 1532 2.21e-08 7.343e-06
15 NEUROGENESIS 58 1402 3.162e-08 9.62e-06
16 REGULATION OF ANATOMICAL STRUCTURE MORPHOGENESIS 47 1021 3.308e-08 9.62e-06
17 CONNECTIVE TISSUE DEVELOPMENT 18 194 4.591e-08 1.257e-05
18 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 46 1004 5.402e-08 1.396e-05
19 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 38 750 6.829e-08 1.672e-05
20 MUSCLE STRUCTURE DEVELOPMENT 27 432 1.019e-07 2.372e-05
21 CELLULAR RESPONSE TO HORMONE STIMULUS 31 552 1.268e-07 2.81e-05
22 PROTEIN PHOSPHORYLATION 43 944 1.791e-07 3.727e-05
23 MESENCHYME DEVELOPMENT 17 190 1.842e-07 3.727e-05
24 POSITIVE REGULATION OF CELL DIFFERENTIATION 39 823 2.578e-07 4.999e-05
25 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 62 1656 3.549e-07 6.605e-05
26 RHYTHMIC PROCESS 21 298 3.964e-07 6.832e-05
27 REGULATION OF CELLULAR COMPONENT MOVEMENT 37 771 3.926e-07 6.832e-05
28 REGULATION OF PROTEIN MODIFICATION PROCESS 63 1710 4.913e-07 8.164e-05
29 VASCULATURE DEVELOPMENT 27 469 5.213e-07 8.363e-05
30 ANATOMICAL STRUCTURE FORMATION INVOLVED IN MORPHOGENESIS 42 957 6.734e-07 9.216e-05
31 INTRACELLULAR SIGNAL TRANSDUCTION 59 1572 6.589e-07 9.216e-05
32 ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY 34 689 6.352e-07 9.216e-05
33 RESPONSE TO OXYGEN CONTAINING COMPOUND 54 1381 6.03e-07 9.216e-05
34 REGULATION OF CELL PROLIFERATION 57 1496 6.496e-07 9.216e-05
35 ORGAN GROWTH 10 68 7.017e-07 9.328e-05
36 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 66 1848 7.564e-07 9.551e-05
37 RESPONSE TO HORMONE 40 893 7.595e-07 9.551e-05
38 POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 44 1036 8.677e-07 0.0001035
39 POSITIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 44 1036 8.677e-07 0.0001035
40 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 69 1977 9.312e-07 0.0001083
41 NEGATIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 35 740 1.147e-06 0.0001302
42 ORGAN MORPHOGENESIS 38 841 1.186e-06 0.0001314
43 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 64 1805 1.469e-06 0.0001553
44 POSITIVE REGULATION OF CELL PROLIFERATION 37 814 1.437e-06 0.0001553
45 HEART DEVELOPMENT 26 466 1.524e-06 0.0001571
46 REGULATION OF NEURON PROJECTION DEVELOPMENT 24 408 1.553e-06 0.0001571
47 CELL DEVELOPMENT 54 1426 1.606e-06 0.000159
48 REGULATION OF CELL DEATH 55 1472 1.91e-06 0.0001851
49 REGULATION OF MAPK CASCADE 32 660 2e-06 0.0001899
50 MESENCHYMAL CELL DIFFERENTIATION 13 134 2.084e-06 0.000194
51 PHOSPHORYLATION 48 1228 2.761e-06 0.0002519
52 POSITIVE REGULATION OF RESPONSE TO STIMULUS 66 1929 3.314e-06 0.0002965
53 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 51 1360 4.271e-06 0.000375
54 TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 33 724 5.153e-06 0.000444
55 POSITIVE REGULATION OF MAPK CASCADE 25 470 5.625e-06 0.0004759
56 CARTILAGE DEVELOPMENT 13 147 5.851e-06 0.0004777
57 CELLULAR RESPONSE TO STEROID HORMONE STIMULUS 16 218 5.755e-06 0.0004777
58 REGULATION OF RESPONSE TO WOUNDING 23 413 6.359e-06 0.0005102
59 REGULATION OF SYSTEM PROCESS 26 507 7.015e-06 0.0005532
60 NEGATIVE REGULATION OF PHOSPHORUS METABOLIC PROCESS 27 541 7.655e-06 0.0005796
61 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 37 876 7.723e-06 0.0005796
62 NEGATIVE REGULATION OF PHOSPHATE METABOLIC PROCESS 27 541 7.655e-06 0.0005796
63 HEART TRABECULA MORPHOGENESIS 6 26 8.376e-06 0.0006186
64 TRABECULA MORPHOGENESIS 7 39 8.675e-06 0.000621
65 DEVELOPMENTAL GROWTH 20 333 8.554e-06 0.000621
66 POSITIVE REGULATION OF MOLECULAR FUNCTION 61 1791 9.582e-06 0.0006654
67 BLOOD VESSEL MORPHOGENESIS 21 364 9.443e-06 0.0006654
68 SKELETAL SYSTEM DEVELOPMENT 24 455 9.966e-06 0.000682
69 RESPONSE TO LIPID 37 888 1.045e-05 0.0007045
70 REGULATION OF CELLULAR RESPONSE TO GROWTH FACTOR STIMULUS 16 229 1.073e-05 0.0007131
71 HORMONE MEDIATED SIGNALING PATHWAY 13 158 1.284e-05 0.0008416
72 CIRCADIAN REGULATION OF GENE EXPRESSION 8 57 1.32e-05 0.0008491
73 REGULATION OF CELL PROJECTION ORGANIZATION 27 558 1.334e-05 0.0008491
74 REGULATION OF PRI MIRNA TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 5 17 1.35e-05 0.0008491
75 RESPONSE TO STEROID HORMONE 25 497 1.462e-05 0.0009073
76 REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 12 138 1.583e-05 0.0009693
77 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 47 1275 1.638e-05 0.0009898
78 TISSUE MORPHOGENESIS 26 533 1.68e-05 0.001002
79 GROWTH 22 410 1.798e-05 0.001059
80 TUBE MORPHOGENESIS 19 323 1.917e-05 0.001115
81 NEGATIVE REGULATION OF NITROGEN COMPOUND METABOLIC PROCESS 53 1517 2.006e-05 0.001151
82 POSITIVE REGULATION OF PROTEIN MODIFICATION PROCESS 43 1135 2.028e-05 0.001151
83 STEM CELL DIFFERENTIATION 14 190 2.105e-05 0.00118
84 POSITIVE REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 5 19 2.458e-05 0.001359
85 POSITIVE REGULATION OF PHOSPHATIDYLINOSITOL 3 KINASE SIGNALING 8 62 2.482e-05 0.001359
86 POSITIVE REGULATION OF LOCOMOTION 22 420 2.598e-05 0.001389
87 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 37 926 2.598e-05 0.001389
88 NEGATIVE REGULATION OF PHOSPHORYLATION 22 422 2.792e-05 0.001476
89 TUBE DEVELOPMENT 26 552 3.05e-05 0.001595
90 POSITIVE REGULATION OF NEURON DIFFERENTIATION 18 306 3.168e-05 0.001631
91 STEROID HORMONE MEDIATED SIGNALING PATHWAY 11 125 3.19e-05 0.001631
92 CELL MOTILITY 34 835 3.842e-05 0.001922
93 LOCALIZATION OF CELL 34 835 3.842e-05 0.001922
94 RESPONSE TO OXYGEN LEVELS 18 311 3.917e-05 0.001935
95 NEGATIVE REGULATION OF CELL DEATH 35 872 3.95e-05 0.001935
96 TRANSMEMBRANE RECEPTOR PROTEIN TYROSINE KINASE SIGNALING PATHWAY 24 498 4.301e-05 0.002085
97 REGULATION OF HYDROLASE ACTIVITY 47 1327 4.44e-05 0.002087
98 REGULATION OF EPITHELIAL CELL PROLIFERATION 17 285 4.4e-05 0.002087
99 SIGNAL TRANSDUCTION BY PROTEIN PHOSPHORYLATION 21 404 4.422e-05 0.002087
100 REGULATION OF OSSIFICATION 13 178 4.53e-05 0.002108
101 NEGATIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 22 437 4.711e-05 0.002171
102 NEGATIVE REGULATION OF GENE EXPRESSION 51 1493 5.245e-05 0.002324
103 REGULATION OF DEVELOPMENTAL GROWTH 17 289 5.235e-05 0.002324
104 POSITIVE REGULATION OF GENE EXPRESSION 57 1733 5.231e-05 0.002324
105 POSITIVE REGULATION OF CELL DEVELOPMENT 23 472 5.242e-05 0.002324
106 LOCOMOTION 41 1114 6.114e-05 0.002684
107 ANGIOGENESIS 17 293 6.206e-05 0.002699
108 REGULATION OF HOMEOSTATIC PROCESS 22 447 6.578e-05 0.002834
109 TRABECULA FORMATION 5 23 6.673e-05 0.002849
110 POSITIVE REGULATION OF PHOSPHOLIPASE ACTIVITY 7 53 6.89e-05 0.002888
111 CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 24 513 6.842e-05 0.002888
112 CIRCADIAN RHYTHM 11 137 7.41e-05 0.003079
113 POSITIVE REGULATION OF CATALYTIC ACTIVITY 51 1518 7.993e-05 0.003291
114 EMBRYO DEVELOPMENT ENDING IN BIRTH OR EGG HATCHING 25 554 8.601e-05 0.003511
115 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 32 799 8.883e-05 0.003594
116 REGULATION OF PHOSPHOLIPASE C ACTIVITY 6 39 9.599e-05 0.003818
117 POSITIVE REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 6 39 9.599e-05 0.003818
118 MUSCLE TISSUE DEVELOPMENT 16 275 9.833e-05 0.003857
119 POSITIVE REGULATION OF MUSCLE TISSUE DEVELOPMENT 7 56 9.863e-05 0.003857
120 POSITIVE REGULATION OF PROTEIN METABOLIC PROCESS 50 1492 0.0001006 0.0039
121 MUSCLE ORGAN DEVELOPMENT 16 277 0.000107 0.004095
122 RESPONSE TO ORGANIC CYCLIC COMPOUND 35 917 0.0001074 0.004095
123 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 18 337 0.0001096 0.004145
124 BIOLOGICAL ADHESION 38 1032 0.0001139 0.004273
125 HEART TRABECULA FORMATION 4 14 0.0001185 0.00441
126 NEGATIVE REGULATION OF CELL COMMUNICATION 42 1192 0.00013 0.004799
127 POSITIVE REGULATION OF NERVOUS SYSTEM DEVELOPMENT 21 437 0.000134 0.004908
128 REGULATION OF CARBOHYDRATE METABOLIC PROCESS 12 172 0.0001366 0.004966
129 REGULATION OF CELL SUBSTRATE ADHESION 12 173 0.0001443 0.005205
130 POSITIVE REGULATION OF HEART GROWTH 5 27 0.0001502 0.005363
131 INOSITOL LIPID MEDIATED SIGNALING 10 124 0.000151 0.005363
132 RESPONSE TO GROWTH FACTOR 22 475 0.0001578 0.005561
133 RESPONSE TO CORTICOSTEROID 12 176 0.0001696 0.005932
134 MUSCLE HYPERTROPHY 5 28 0.00018 0.006204
135 REGULATION OF FATTY ACID OXIDATION 5 28 0.00018 0.006204
136 POSITIVE REGULATION OF NEURON PROJECTION DEVELOPMENT 14 232 0.0001818 0.006221
137 CARDIAC CHAMBER MORPHOGENESIS 9 104 0.0001887 0.006411
138 NEGATIVE REGULATION OF LOCOMOTION 15 263 0.0002004 0.006756
139 RESPONSE TO ABIOTIC STIMULUS 37 1024 0.0002039 0.006826
140 NEGATIVE REGULATION OF ADHERENS JUNCTION ORGANIZATION 4 16 0.0002089 0.006867
141 DERMATAN SULFATE PROTEOGLYCAN METABOLIC PROCESS 4 16 0.0002089 0.006867
142 REGULATION OF MUSCLE ADAPTATION 7 63 0.0002096 0.006867
143 REGULATION OF CARDIAC MUSCLE CELL PROLIFERATION 5 29 0.0002141 0.00687
144 POSITIVE REGULATION OF CARDIAC MUSCLE TISSUE DEVELOPMENT 5 29 0.0002141 0.00687
145 POSITIVE REGULATION OF CARTILAGE DEVELOPMENT 5 29 0.0002141 0.00687
146 REGULATION OF GLUCOSE METABOLIC PROCESS 9 106 0.0002181 0.006951
147 MUSCLE CELL DIFFERENTIATION 14 237 0.0002266 0.007174
148 POSITIVE REGULATION OF RESPONSE TO EXTERNAL STIMULUS 16 296 0.0002284 0.007182
149 REGULATION OF PHOSPHOLIPASE ACTIVITY 7 64 0.0002314 0.007227
150 NEGATIVE REGULATION OF DNA BINDING 6 46 0.0002459 0.007628
151 NEGATIVE REGULATION OF CELL MATRIX ADHESION 5 30 0.0002528 0.007791
152 HEART MORPHOGENESIS 13 212 0.0002626 0.008038
153 MULTI MULTICELLULAR ORGANISM PROCESS 13 213 0.0002748 0.008359
154 REGULATION OF FATTY ACID METABOLIC PROCESS 8 87 0.000282 0.008466
155 POSITIVE REGULATION OF LIPASE ACTIVITY 7 66 0.0002807 0.008466
156 POSITIVE REGULATION OF ENDOTHELIAL CELL MIGRATION 7 67 0.0003083 0.00908
157 OVULATION CYCLE PROCESS 8 88 0.0003051 0.00908
158 REGULATION OF GTPASE ACTIVITY 27 673 0.0003077 0.00908
159 CELLULAR RESPONSE TO ORGANIC CYCLIC COMPOUND 21 465 0.0003108 0.009095
160 RESPONSE TO NITROGEN COMPOUND 32 859 0.0003261 0.009483
161 REGULATION OF OSTEOBLAST DIFFERENTIATION 9 112 0.0003297 0.00953
162 REGULATION OF CELL JUNCTION ASSEMBLY 7 68 0.0003381 0.00971
163 OVULATION 4 18 0.0003407 0.009724
164 POSITIVE REGULATION OF BMP SIGNALING PATHWAY 5 32 0.0003461 0.009821
165 PHOSPHATIDYLINOSITOL 3 PHOSPHATE BIOSYNTHETIC PROCESS 6 49 0.0003497 0.009821
166 RESPONSE TO EXTERNAL STIMULUS 56 1821 0.0003504 0.009821
167 REGULATION OF CELL MATRIX ADHESION 8 90 0.0003558 0.009914
168 REGULATION OF PROTEIN SERINE THREONINE KINASE ACTIVITY 21 470 0.0003581 0.009917
169 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 15 278 0.0003627 0.009986
170 EMBRYONIC MORPHOGENESIS 23 539 0.000365 0.00999
NumGOOverlapSizeP ValueAdj. P Value
1 RNA POLYMERASE II TRANSCRIPTION FACTOR ACTIVITY SEQUENCE SPECIFIC DNA BINDING 37 629 2.088e-09 1.94e-06
2 NUCLEIC ACID BINDING TRANSCRIPTION FACTOR ACTIVITY 52 1199 4.017e-08 1.866e-05
3 KINASE ACTIVITY 40 842 1.678e-07 5.196e-05
4 TRANSCRIPTION FACTOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 22 328 4.871e-07 0.0001131
5 REGULATORY REGION NUCLEIC ACID BINDING 37 818 1.612e-06 0.0002995
6 PROTEIN KINASE ACTIVITY 31 640 2.964e-06 0.0004589
7 SEQUENCE SPECIFIC DNA BINDING 42 1037 5.157e-06 0.0006844
8 DOUBLE STRANDED DNA BINDING 34 764 6.158e-06 0.0007151
9 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 40 992 9.736e-06 0.001005
10 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II TRANSCRIPTION REGULATORY REGION SEQUENCE SPECIFIC BINDING 19 315 1.351e-05 0.00119
11 ZINC ION BINDING 44 1155 1.409e-05 0.00119
12 STEROID HORMONE RECEPTOR ACTIVITY 8 59 1.712e-05 0.001326
13 ACTIN BINDING 21 393 2.961e-05 0.002116
14 TRANSCRIPTION FACTOR ACTIVITY PROTEIN BINDING 27 588 3.337e-05 0.002214
15 KINASE BINDING 27 606 5.581e-05 0.003457
16 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 8 70 6.059e-05 0.003518
17 ENZYME BINDING 56 1737 0.0001047 0.005721
18 RAS GUANYL NUCLEOTIDE EXCHANGE FACTOR ACTIVITY 14 228 0.0001517 0.007015
19 TRANSITION METAL ION BINDING 47 1400 0.0001586 0.007015
20 TRANSCRIPTIONAL ACTIVATOR ACTIVITY RNA POLYMERASE II CORE PROMOTER PROXIMAL REGION SEQUENCE SPECIFIC BINDING 14 226 0.0001383 0.007015
21 MACROMOLECULAR COMPLEX BINDING 47 1399 0.000156 0.007015
22 X1 PHOSPHATIDYLINOSITOL 3 KINASE ACTIVITY 6 43 0.0001681 0.007097
23 GLYCOSAMINOGLYCAN BINDING 13 205 0.000189 0.007636
24 HEPARIN BINDING 11 157 0.0002484 0.00923
25 TRANSCRIPTION FACTOR BINDING 23 524 0.000245 0.00923
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 21 295 3.354e-07 1.744e-05
2 PI3K_Akt_signaling_pathway_hsa04151 21 352 5.654e-06 0.000147
3 Rap1_signaling_pathway_hsa04015 15 206 1.237e-05 0.0002143
4 Ras_signaling_pathway_hsa04014 15 232 4.958e-05 0.000549
5 FoxO_signaling_pathway_hsa04068 11 132 5.279e-05 0.000549
6 cGMP_PKG_signaling_pathway_hsa04022 12 163 8.188e-05 0.0007097
7 Phosphatidylinositol_signaling_system_hsa04070 9 99 0.0001294 0.0009614
8 Focal_adhesion_hsa04510 12 199 0.0005214 0.003029
9 Phospholipase_D_signaling_pathway_hsa04072 10 146 0.0005631 0.003029
10 AMPK_signaling_pathway_hsa04152 9 121 0.0005824 0.003029
11 Cellular_senescence_hsa04218 10 160 0.001141 0.005394
12 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 9 139 0.001561 0.006763
13 Oocyte_meiosis_hsa04114 8 124 0.002869 0.01148
14 cAMP_signaling_pathway_hsa04024 10 198 0.00535 0.01987
15 Regulation_of_actin_cytoskeleton_hsa04810 10 208 0.007486 0.02595
16 Sphingolipid_signaling_pathway_hsa04071 7 118 0.008102 0.02633
17 HIF_1_signaling_pathway_hsa04066 6 100 0.01313 0.04016
18 Apelin_signaling_pathway_hsa04371 7 137 0.01737 0.04826
19 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.0181 0.04826
20 TNF_signaling_pathway_hsa04668 6 108 0.01856 0.04826
21 Cell_adhesion_molecules_.CAMs._hsa04514 7 145 0.02292 0.05675
22 Calcium_signaling_pathway_hsa04020 8 182 0.02565 0.06063
23 Jak_STAT_signaling_pathway_hsa04630 7 162 0.03851 0.08707
24 p53_signaling_pathway_hsa04115 4 68 0.04272 0.09257
25 Apoptosis_hsa04210 6 138 0.05197 0.1081
26 Wnt_signaling_pathway_hsa04310 6 146 0.06473 0.1295
27 mTOR_signaling_pathway_hsa04150 6 151 0.07355 0.1417
28 Hippo_signaling_pathway_hsa04390 6 154 0.07916 0.1435
29 TGF_beta_signaling_pathway_hsa04350 4 84 0.08004 0.1435
30 Gap_junction_hsa04540 4 88 0.09127 0.1582
31 Endocytosis_hsa04144 8 244 0.1026 0.1721
32 VEGF_signaling_pathway_hsa04370 3 59 0.1061 0.1724
33 Adherens_junction_hsa04520 3 72 0.1631 0.2571
34 ECM_receptor_interaction_hsa04512 3 82 0.2119 0.3241
35 ErbB_signaling_pathway_hsa04012 3 85 0.2271 0.3254
36 Hedgehog_signaling_pathway_hsa04340 2 47 0.2306 0.3254
37 Autophagy_animal_hsa04140 4 128 0.236 0.3254
38 Notch_signaling_pathway_hsa04330 2 48 0.2378 0.3254
39 Cytokine_cytokine_receptor_interaction_hsa04060 7 270 0.2693 0.3591
40 NF_kappa_B_signaling_pathway_hsa04064 3 95 0.2791 0.3628
41 Neuroactive_ligand_receptor_interaction_hsa04080 7 278 0.2935 0.3722
42 Phagosome_hsa04145 4 152 0.3394 0.4202
43 Necroptosis_hsa04217 4 164 0.3921 0.4741
44 Tight_junction_hsa04530 4 170 0.4182 0.4943
45 Cell_cycle_hsa04110 3 124 0.4315 0.4986

Quest ID: 507618741e3f2819a9bff01e75d20995