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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-877-5p ABHD2 -1.17 0.04417 0.63 0.15716 mirMAP -0.14 0.01678 NA
2 hsa-miR-877-5p AR -1.17 0.04417 -0.52 0.55352 MirTarget -0.35 0.00199 NA
3 hsa-miR-877-5p ARHGEF6 -1.17 0.04417 -1.34 0.00865 miRNAWalker2 validate -0.14 0.0328 NA
4 hsa-miR-877-5p C1orf21 -1.17 0.04417 0.33 0.36678 mirMAP -0.17 0.00023 NA
5 hsa-miR-877-5p CD302 -1.17 0.04417 -0.37 0.35811 MirTarget -0.18 0.00033 NA
6 hsa-miR-877-5p CDH19 -1.17 0.04417 0.13 0.90694 MirTarget -0.37 0.0088 NA
7 hsa-miR-877-5p CDR2L -1.17 0.04417 1.26 0.00688 miRNAWalker2 validate -0.12 0.04724 NA
8 hsa-miR-877-5p COL6A3 -1.17 0.04417 -0.1 0.89132 MirTarget; miRNATAP -0.32 0.00107 NA
9 hsa-miR-877-5p DLG2 -1.17 0.04417 -0.5 0.51164 MirTarget -0.22 0.0236 NA
10 hsa-miR-877-5p EGFR -1.17 0.04417 0.65 0.25306 mirMAP -0.27 0.00018 NA
11 hsa-miR-877-5p EMP1 -1.17 0.04417 0.76 0.20317 MirTarget -0.24 0.00194 NA
12 hsa-miR-877-5p FAT3 -1.17 0.04417 -1.22 0.10046 MirTarget -0.21 0.02711 NA
13 hsa-miR-877-5p FLI1 -1.17 0.04417 -1.49 0.00419 MirTarget; miRNATAP -0.15 0.0296 NA
14 hsa-miR-877-5p FOXC1 -1.17 0.04417 0.86 0.09648 miRNAWalker2 validate -0.19 0.00532 NA
15 hsa-miR-877-5p FOXP2 -1.17 0.04417 0.26 0.75107 miRNATAP -0.24 0.02828 NA
16 hsa-miR-877-5p GAS7 -1.17 0.04417 -0.64 0.20432 mirMAP -0.17 0.00956 NA
17 hsa-miR-877-5p GLIPR1 -1.17 0.04417 -1.35 0.01572 MirTarget -0.23 0.00184 NA
18 hsa-miR-877-5p GNB4 -1.17 0.04417 -0.95 0.05626 MirTarget -0.19 0.00331 NA
19 hsa-miR-877-5p GRIN2A -1.17 0.04417 0.58 0.47505 mirMAP -0.21 0.0441 NA
20 hsa-miR-877-5p HEYL -1.17 0.04417 0.19 0.73062 MirTarget -0.18 0.01464 NA
21 hsa-miR-877-5p HIF3A -1.17 0.04417 -0.32 0.63544 mirMAP -0.2 0.02564 NA
22 hsa-miR-877-5p HLA-DRA -1.17 0.04417 -1.52 0.01113 MirTarget -0.23 0.00301 NA
23 hsa-miR-877-5p IGF2BP2 -1.17 0.04417 0.7 0.34724 miRNAWalker2 validate; MirTarget; miRNATAP -0.2 0.04187 NA
24 hsa-miR-877-5p IL17RD -1.17 0.04417 -0.42 0.32296 mirMAP -0.18 0.00089 NA
25 hsa-miR-877-5p ITGA9 -1.17 0.04417 -0.7 0.28742 mirMAP -0.23 0.00837 NA
26 hsa-miR-877-5p ITGB8 -1.17 0.04417 1.47 0.00341 MirTarget -0.15 0.02551 NA
27 hsa-miR-877-5p KCNJ15 -1.17 0.04417 -0.76 0.51059 MirTarget -0.45 0.00269 NA
28 hsa-miR-877-5p KIF26B -1.17 0.04417 0.51 0.44044 mirMAP -0.21 0.01493 NA
29 hsa-miR-877-5p KIRREL -1.17 0.04417 -0.45 0.56708 mirMAP -0.26 0.01152 NA
30 hsa-miR-877-5p LEPR -1.17 0.04417 0.25 0.64924 miRNAWalker2 validate -0.2 0.005 NA
31 hsa-miR-877-5p LPCAT2 -1.17 0.04417 0.34 0.49673 MirTarget -0.17 0.00797 NA
32 hsa-miR-877-5p LRRC32 -1.17 0.04417 -0.18 0.67416 MirTarget -0.18 0.0011 NA
33 hsa-miR-877-5p MACC1 -1.17 0.04417 0.54 0.4139 MirTarget -0.19 0.02652 NA
34 hsa-miR-877-5p MMP16 -1.17 0.04417 0.44 0.53679 MirTarget -0.19 0.04021 NA
35 hsa-miR-877-5p MMRN1 -1.17 0.04417 0.14 0.87694 MirTarget -0.28 0.01763 NA
36 hsa-miR-877-5p MTR -1.17 0.04417 -0.21 0.39473 mirMAP -0.1 0.00137 NA
37 hsa-miR-877-5p NAV3 -1.17 0.04417 -0.64 0.27646 MirTarget -0.23 0.00293 NA
38 hsa-miR-877-5p NFIA -1.17 0.04417 -0.29 0.37644 mirMAP -0.24 0 NA
39 hsa-miR-877-5p NOTCH2NL -1.17 0.04417 -0.52 0.32099 miRNAWalker2 validate -0.24 0.0004 NA
40 hsa-miR-877-5p NR2F2 -1.17 0.04417 -0.12 0.68426 miRNAWalker2 validate -0.19 0 NA
41 hsa-miR-877-5p NRK -1.17 0.04417 0.76 0.41131 miRNATAP -0.41 0.0006 NA
42 hsa-miR-877-5p NTRK3 -1.17 0.04417 -0.83 0.25737 mirMAP -0.28 0.00304 NA
43 hsa-miR-877-5p PCDH19 -1.17 0.04417 -0.19 0.7825 MirTarget; miRNATAP -0.29 0.00084 NA
44 hsa-miR-877-5p PPP1R12B -1.17 0.04417 -0.57 0.23737 mirMAP -0.14 0.02766 NA
45 hsa-miR-877-5p PRELP -1.17 0.04417 -0 0.99597 mirMAP -0.32 0.00021 NA
46 hsa-miR-877-5p PRND -1.17 0.04417 -0.06 0.9492 miRNAWalker2 validate -0.43 0.00036 NA
47 hsa-miR-877-5p PTGFRN -1.17 0.04417 0.59 0.16374 miRNAWalker2 validate -0.23 2.0E-5 NA
48 hsa-miR-877-5p RBMS3 -1.17 0.04417 -0.55 0.39255 mirMAP -0.35 2.0E-5 NA
49 hsa-miR-877-5p RFTN2 -1.17 0.04417 -0.33 0.44072 MirTarget -0.23 2.0E-5 NA
50 hsa-miR-877-5p SH3PXD2A -1.17 0.04417 -0.19 0.57936 mirMAP -0.13 0.00409 NA
51 hsa-miR-877-5p SH3PXD2B -1.17 0.04417 -0.06 0.90009 mirMAP -0.19 0.00154 NA
52 hsa-miR-877-5p SHROOM4 -1.17 0.04417 -0.17 0.67631 mirMAP -0.15 0.00401 NA
53 hsa-miR-877-5p SKIL -1.17 0.04417 0.03 0.94505 MirTarget; miRNATAP -0.15 0.018 NA
54 hsa-miR-877-5p SLAMF6 -1.17 0.04417 -1.36 0.09825 MirTarget -0.27 0.01186 NA
55 hsa-miR-877-5p SLC16A14 -1.17 0.04417 -0.71 0.07222 MirTarget -0.15 0.00434 NA
56 hsa-miR-877-5p STYK1 -1.17 0.04417 2.74 0.00154 MirTarget -0.23 0.03869 NA
57 hsa-miR-877-5p SUCNR1 -1.17 0.04417 0.15 0.88076 MirTarget -0.27 0.04022 NA
58 hsa-miR-877-5p SYK -1.17 0.04417 -1 0.02646 mirMAP -0.14 0.01335 NA
59 hsa-miR-877-5p TMEM144 -1.17 0.04417 0.62 0.19068 MirTarget -0.23 0.00018 NA
60 hsa-miR-877-5p TMEM98 -1.17 0.04417 0.29 0.49354 mirMAP -0.15 0.00607 NA
61 hsa-miR-877-5p TRAM2 -1.17 0.04417 -0.23 0.5144 mirMAP -0.11 0.0175 NA
62 hsa-miR-877-5p TSHZ2 -1.17 0.04417 -0.35 0.56827 MirTarget -0.31 8.0E-5 NA
63 hsa-miR-877-5p ZBTB38 -1.17 0.04417 -0.18 0.55895 miRNAWalker2 validate -0.11 0.00582 NA
64 hsa-miR-877-5p ZDHHC15 -1.17 0.04417 -0.6 0.29302 MirTarget -0.17 0.02463 NA
65 hsa-miR-877-5p ZNF704 -1.17 0.04417 -0.06 0.91115 mirMAP -0.2 0.00427 NA
66 hsa-miR-877-5p ZPLD1 -1.17 0.04417 -0.24 0.82715 MirTarget -0.45 0.00157 NA
67 hsa-miR-877-5p ZSCAN23 -1.17 0.04417 -1.03 0.18274 miRNATAP -0.21 0.03555 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 RECEPTOR COMPLEX 8 327 1.322e-05 0.00772

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Focal_adhesion_hsa04510 5 199 0.0005432 0.01725
2 Regulation_of_actin_cytoskeleton_hsa04810 5 208 0.0006636 0.01725
3 PI3K_Akt_signaling_pathway_hsa04151 6 352 0.001152 0.01997
4 ECM_receptor_interaction_hsa04512 3 82 0.002634 0.03425
5 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.01275 0.1326
6 Ras_signaling_pathway_hsa04014 3 232 0.04292 0.372
7 Phospholipase_D_signaling_pathway_hsa04072 2 146 0.08609 0.6395
8 Jak_STAT_signaling_pathway_hsa04630 2 162 0.1026 0.6668
9 Calcium_signaling_pathway_hsa04020 2 182 0.1243 0.7168
10 cAMP_signaling_pathway_hsa04024 2 198 0.1424 0.7168
11 Rap1_signaling_pathway_hsa04015 2 206 0.1516 0.7168
12 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.2289 0.8252
13 Neuroactive_ligand_receptor_interaction_hsa04080 2 278 0.2388 0.8252

Quest ID: 6990f5dee56e0b9ade73cf588b432f8f