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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-532-3p ACHE 0.64 0.21484 -1.22 0.32994 miRNATAP -0.31 0.02272 NA
2 hsa-miR-532-3p ACTN1 0.64 0.21484 -1.38 0.00663 miRNATAP -0.28 0 NA
3 hsa-miR-532-3p ADAMTS2 0.64 0.21484 -2.49 0.0191 mirMAP -0.35 0.00281 NA
4 hsa-miR-532-3p AEBP2 0.64 0.21484 -0.23 0.54141 PITA; miRNATAP -0.13 0.0011 NA
5 hsa-miR-532-3p ATP11B 0.64 0.21484 0.87 0.09528 MirTarget -0.18 0.0014 NA
6 hsa-miR-532-3p BASP1 0.64 0.21484 -1.12 0.32909 PITA -0.49 0.0001 NA
7 hsa-miR-532-3p BCL2L2 0.64 0.21484 -0.87 0.03527 MirTarget; miRNATAP -0.11 0.01255 NA
8 hsa-miR-532-3p BCL9L 0.64 0.21484 -0.12 0.78985 mirMAP -0.16 0.00089 NA
9 hsa-miR-532-3p BDKRB2 0.64 0.21484 -0.48 0.51274 mirMAP -0.31 0.00012 NA
10 hsa-miR-532-3p BTK 0.64 0.21484 0.1 0.9023 miRNATAP -0.35 0.0001 NA
11 hsa-miR-532-3p C6orf132 0.64 0.21484 3.63 0 miRNATAP -0.2 0.01001 NA
12 hsa-miR-532-3p CADM3 0.64 0.21484 -5.71 4.0E-5 MirTarget -0.32 0.0407 NA
13 hsa-miR-532-3p CCDC68 0.64 0.21484 -1.22 0.30525 MirTarget -0.33 0.01125 NA
14 hsa-miR-532-3p CD44 0.64 0.21484 -0.25 0.70262 miRNATAP -0.32 1.0E-5 NA
15 hsa-miR-532-3p CHST2 0.64 0.21484 -0.56 0.58452 MirTarget -0.32 0.00515 NA
16 hsa-miR-532-3p COL1A1 0.64 0.21484 -1.84 0.04283 PITA; miRNATAP -0.26 0.00868 NA
17 hsa-miR-532-3p COL4A4 0.64 0.21484 -1.65 0.17996 miRNATAP -0.36 0.00835 NA
18 hsa-miR-532-3p COL6A6 0.64 0.21484 -3.77 0.00328 MirTarget -0.6 2.0E-5 NA
19 hsa-miR-532-3p CRISPLD2 0.64 0.21484 -3.95 0 miRNATAP -0.23 0.00724 NA
20 hsa-miR-532-3p CSF1 0.64 0.21484 -1.1 0.12732 MirTarget; PITA -0.32 5.0E-5 NA
21 hsa-miR-532-3p CYP26B1 0.64 0.21484 1.59 0.0886 MirTarget; miRNATAP -0.32 0.00205 NA
22 hsa-miR-532-3p DAB2 0.64 0.21484 -2.28 0.00051 PITA -0.22 0.00269 NA
23 hsa-miR-532-3p DAB2IP 0.64 0.21484 -0.67 0.14798 mirMAP -0.15 0.00378 NA
24 hsa-miR-532-3p DOCK2 0.64 0.21484 0.43 0.61271 miRNATAP -0.31 0.00079 NA
25 hsa-miR-532-3p DST 0.64 0.21484 -1.13 0.25105 mirMAP -0.55 0 NA
26 hsa-miR-532-3p DUSP7 0.64 0.21484 0.94 0.22255 mirMAP -0.36 2.0E-5 NA
27 hsa-miR-532-3p EFNB1 0.64 0.21484 0.85 0.25816 PITA; miRNATAP -0.31 0.00018 NA
28 hsa-miR-532-3p EHBP1 0.64 0.21484 -0.97 0.01559 PITA -0.21 0 NA
29 hsa-miR-532-3p ELOVL3 0.64 0.21484 2.95 0.00854 miRNATAP -0.25 0.04718 NA
30 hsa-miR-532-3p ENAH 0.64 0.21484 -0.27 0.60264 miRNATAP -0.12 0.02758 NA
31 hsa-miR-532-3p ETS1 0.64 0.21484 -1.33 0.02728 MirTarget; PITA; miRNATAP -0.16 0.01662 NA
32 hsa-miR-532-3p FAM49A 0.64 0.21484 -1.37 0.09697 MirTarget; miRNATAP -0.27 0.00306 NA
33 hsa-miR-532-3p FGF1 0.64 0.21484 -0.9 0.37514 miRNATAP -0.39 0.00053 NA
34 hsa-miR-532-3p FGF11 0.64 0.21484 2.65 0.01262 mirMAP -0.39 0.00098 NA
35 hsa-miR-532-3p FLYWCH1 0.64 0.21484 -0.5 0.21907 mirMAP -0.11 0.01486 NA
36 hsa-miR-532-3p FOXD3 0.64 0.21484 0.71 0.62954 miRNATAP -0.33 0.04056 NA
37 hsa-miR-532-3p FOXK1 0.64 0.21484 -0.47 0.32974 mirMAP -0.12 0.02695 NA
38 hsa-miR-532-3p FRMD4A 0.64 0.21484 -0.33 0.5329 MirTarget -0.18 0.00144 NA
39 hsa-miR-532-3p GABRA3 0.64 0.21484 3.86 0.03905 MirTarget -0.41 0.046 NA
40 hsa-miR-532-3p GDF6 0.64 0.21484 -1.55 0.35253 PITA; miRNATAP -0.6 0.00112 NA
41 hsa-miR-532-3p GFRA1 0.64 0.21484 -6.72 0 miRNATAP -0.38 0.0097 NA
42 hsa-miR-532-3p GPR68 0.64 0.21484 1.77 0.09939 mirMAP -0.64 0 NA
43 hsa-miR-532-3p GPRC5A 0.64 0.21484 1.52 0.16803 MirTarget -0.37 0.00213 NA
44 hsa-miR-532-3p GRIP2 0.64 0.21484 -1.24 0.23942 MirTarget -0.38 0.00094 NA
45 hsa-miR-532-3p HAS3 0.64 0.21484 3.82 0.00533 PITA; miRNATAP -0.51 0.00083 NA
46 hsa-miR-532-3p HDAC7 0.64 0.21484 -0.75 0.02472 miRNATAP -0.11 0.00222 NA
47 hsa-miR-532-3p HES2 0.64 0.21484 6.53 1.0E-5 mirMAP -0.62 0.00014 NA
48 hsa-miR-532-3p IER2 0.64 0.21484 -0.36 0.48377 miRNATAP -0.13 0.01685 NA
49 hsa-miR-532-3p IFFO2 0.64 0.21484 0.99 0.24976 MirTarget -0.32 0.00075 NA
50 hsa-miR-532-3p IGFBP4 0.64 0.21484 -2.88 1.0E-5 miRNATAP -0.19 0.00836 NA
51 hsa-miR-532-3p IL19 0.64 0.21484 0.99 0.52932 MirTarget; miRNATAP -0.44 0.01047 NA
52 hsa-miR-532-3p KIAA1644 0.64 0.21484 -5.73 0 MirTarget -0.45 0.00036 NA
53 hsa-miR-532-3p LIMK2 0.64 0.21484 1.43 0.00024 MirTarget; miRNATAP -0.2 0 NA
54 hsa-miR-532-3p LMNA 0.64 0.21484 -0.38 0.38032 miRNATAP -0.14 0.0023 NA
55 hsa-miR-532-3p LPCAT3 0.64 0.21484 0.99 0.00587 miRNATAP -0.1 0.0105 NA
56 hsa-miR-532-3p MAFK 0.64 0.21484 -0.78 0.11431 MirTarget -0.15 0.00722 NA
57 hsa-miR-532-3p MEF2D 0.64 0.21484 -1.6 0 mirMAP -0.12 0.00039 NA
58 hsa-miR-532-3p MET 0.64 0.21484 1.26 0.06813 PITA -0.19 0.01423 NA
59 hsa-miR-532-3p MMP14 0.64 0.21484 -0.32 0.55424 miRNATAP -0.25 2.0E-5 NA
60 hsa-miR-532-3p MRVI1 0.64 0.21484 -4.88 0 MirTarget -0.19 0.02905 NA
61 hsa-miR-532-3p MSRB3 0.64 0.21484 -5.12 0 MirTarget; PITA; miRNATAP -0.37 0.00035 NA
62 hsa-miR-532-3p MYOM3 0.64 0.21484 0.75 0.53011 MirTarget -0.43 0.00109 NA
63 hsa-miR-532-3p NEFM 0.64 0.21484 -2.86 0.12361 miRNATAP -0.55 0.00696 NA
64 hsa-miR-532-3p NFASC 0.64 0.21484 -2.43 0.02593 MirTarget; miRNATAP -0.44 0.00024 NA
65 hsa-miR-532-3p NPTX1 0.64 0.21484 -2.6 0.07363 PITA; miRNATAP -0.33 0.0368 NA
66 hsa-miR-532-3p OLFML2A 0.64 0.21484 -2.28 0.01213 mirMAP -0.37 0.00018 NA
67 hsa-miR-532-3p OSCAR 0.64 0.21484 0.88 0.19649 MirTarget -0.19 0.01053 NA
68 hsa-miR-532-3p P2RX6 0.64 0.21484 -1.55 0.13594 mirMAP -0.43 0.00017 NA
69 hsa-miR-532-3p PACS1 0.64 0.21484 0.13 0.65148 miRNATAP -0.11 0.00083 NA
70 hsa-miR-532-3p PAPPA 0.64 0.21484 -3.34 0.00413 PITA; miRNATAP -0.5 9.0E-5 NA
71 hsa-miR-532-3p PDE4D 0.64 0.21484 -1.19 0.161 PITA; miRNATAP -0.22 0.02087 NA
72 hsa-miR-532-3p PDE7B 0.64 0.21484 -4.29 0 miRNATAP -0.26 0.00398 NA
73 hsa-miR-532-3p PDPN 0.64 0.21484 -1.72 0.15988 miRNATAP -0.54 5.0E-5 NA
74 hsa-miR-532-3p PFKM 0.64 0.21484 -1.48 0.00929 miRNATAP -0.19 0.00198 NA
75 hsa-miR-532-3p PID1 0.64 0.21484 -4.4 4.0E-5 MirTarget -0.47 9.0E-5 NA
76 hsa-miR-532-3p PIM1 0.64 0.21484 -0.4 0.51127 miRNATAP -0.33 0 NA
77 hsa-miR-532-3p PKP1 0.64 0.21484 6.74 0.00325 mirMAP -1.04 3.0E-5 NA
78 hsa-miR-532-3p PLA2G2F 0.64 0.21484 4.61 0.01694 mirMAP -0.5 0.0191 NA
79 hsa-miR-532-3p PLCH2 0.64 0.21484 5.05 0.00012 mirMAP -0.75 0 NA
80 hsa-miR-532-3p PLXDC1 0.64 0.21484 -2.18 0.00118 mirMAP -0.22 0.00275 NA
81 hsa-miR-532-3p PMEPA1 0.64 0.21484 -0.44 0.56222 mirMAP -0.44 0 NA
82 hsa-miR-532-3p POU2F2 0.64 0.21484 0.12 0.86884 mirMAP -0.2 0.00981 NA
83 hsa-miR-532-3p PPM1F 0.64 0.21484 -1.24 0.00296 MirTarget; mirMAP -0.12 0.01133 NA
84 hsa-miR-532-3p PPP1R16B 0.64 0.21484 -1.98 0.01048 miRNATAP -0.17 0.04201 NA
85 hsa-miR-532-3p PROS1 0.64 0.21484 -2.55 0.00742 MirTarget -0.23 0.03121 NA
86 hsa-miR-532-3p PTGIS 0.64 0.21484 -7.95 0 miRNATAP -0.32 0.02444 NA
87 hsa-miR-532-3p PTPRK 0.64 0.21484 0.62 0.1688 PITA; miRNATAP -0.13 0.01068 NA
88 hsa-miR-532-3p RASIP1 0.64 0.21484 -0.75 0.38583 PITA -0.28 0.00353 NA
89 hsa-miR-532-3p RCSD1 0.64 0.21484 -0.44 0.56286 miRNATAP -0.21 0.01151 NA
90 hsa-miR-532-3p RIMKLB 0.64 0.21484 -1.03 0.12217 MirTarget -0.24 0.00089 NA
91 hsa-miR-532-3p RIMS3 0.64 0.21484 -1.71 0.06503 mirMAP -0.42 3.0E-5 NA
92 hsa-miR-532-3p RNF145 0.64 0.21484 0.64 0.1303 MirTarget -0.11 0.02374 NA
93 hsa-miR-532-3p RNF165 0.64 0.21484 1.49 0.18361 mirMAP -0.34 0.00534 NA
94 hsa-miR-532-3p RPS6KA2 0.64 0.21484 -2.65 0.0006 MirTarget; mirMAP -0.17 0.04214 NA
95 hsa-miR-532-3p S1PR5 0.64 0.21484 4.58 0.00087 miRNATAP -0.79 0 NA
96 hsa-miR-532-3p SAMD4A 0.64 0.21484 -3.02 5.0E-5 MirTarget -0.3 0.00034 NA
97 hsa-miR-532-3p SCN2B 0.64 0.21484 -6.08 0 mirMAP -0.29 0.03048 NA
98 hsa-miR-532-3p SFN 0.64 0.21484 8.01 0 miRNATAP -0.43 0.00047 NA
99 hsa-miR-532-3p SH2D5 0.64 0.21484 0.1 0.94275 mirMAP -0.35 0.03082 NA
100 hsa-miR-532-3p SH3PXD2A 0.64 0.21484 -0.79 0.07818 MirTarget -0.13 0.00658 NA
101 hsa-miR-532-3p SLC6A17 0.64 0.21484 1.12 0.49329 mirMAP -0.47 0.0085 NA
102 hsa-miR-532-3p SLC7A5 0.64 0.21484 4.09 3.0E-5 mirMAP -0.28 0.01172 NA
103 hsa-miR-532-3p SNX24 0.64 0.21484 1.33 0.00086 MirTarget -0.14 0.0015 NA
104 hsa-miR-532-3p SNX33 0.64 0.21484 -0.11 0.81151 mirMAP -0.21 2.0E-5 NA
105 hsa-miR-532-3p SPARC 0.64 0.21484 -2.52 0.00099 miRNATAP -0.2 0.01751 NA
106 hsa-miR-532-3p SPN 0.64 0.21484 0.8 0.32045 mirMAP -0.26 0.00366 NA
107 hsa-miR-532-3p ST3GAL1 0.64 0.21484 -0.57 0.39908 mirMAP -0.24 0.0016 NA
108 hsa-miR-532-3p ST6GALNAC2 0.64 0.21484 2.82 7.0E-5 MirTarget -0.21 0.00786 NA
109 hsa-miR-532-3p STAT1 0.64 0.21484 2.01 0.00164 MirTarget -0.24 0.00078 NA
110 hsa-miR-532-3p STX1B 0.64 0.21484 -2.34 0.0065 mirMAP -0.24 0.01175 NA
111 hsa-miR-532-3p SYDE1 0.64 0.21484 -2.73 0.0008 miRNATAP -0.58 0 NA
112 hsa-miR-532-3p SYNM 0.64 0.21484 -2.53 0.00057 miRNATAP -0.19 0.01883 NA
113 hsa-miR-532-3p TBC1D2B 0.64 0.21484 -1.21 0.00066 MirTarget -0.16 5.0E-5 NA
114 hsa-miR-532-3p TEAD3 0.64 0.21484 -0.93 0.00615 miRNATAP -0.1 0.00523 NA
115 hsa-miR-532-3p TREM2 0.64 0.21484 3.37 0.00199 miRNATAP -0.26 0.03219 NA
116 hsa-miR-532-3p TUB 0.64 0.21484 -4.33 0.00017 mirMAP -0.32 0.01306 NA
117 hsa-miR-532-3p UST 0.64 0.21484 -1.67 0.07389 miRNATAP -0.25 0.01469 NA
118 hsa-miR-532-3p WNT9A 0.64 0.21484 -1.18 0.2661 mirMAP -0.27 0.01919 NA
119 hsa-miR-532-3p ZNF462 0.64 0.21484 -0.82 0.45482 PITA -0.32 0.00935 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
1 EXTRACELLULAR MATRIX 13 426 1.563e-06 0.0003043
2 CELL JUNCTION 22 1151 1.044e-06 0.0003043
3 PROTEINACEOUS EXTRACELLULAR MATRIX 12 356 1.447e-06 0.0003043

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 ECM_receptor_interaction_hsa04512 4 82 0.001458 0.07579
2 Focal_adhesion_hsa04510 5 199 0.006788 0.141
3 Regulation_of_actin_cytoskeleton_hsa04810 5 208 0.008138 0.141
4 Ras_signaling_pathway_hsa04014 5 232 0.01263 0.141
5 Hippo_signaling_pathway_hsa04390 4 154 0.01356 0.141
6 PI3K_Akt_signaling_pathway_hsa04151 6 352 0.01881 0.1631
7 TNF_signaling_pathway_hsa04668 3 108 0.0267 0.1983
8 MAPK_signaling_pathway_hsa04010 5 295 0.03167 0.2059
9 Cell_adhesion_molecules_.CAMs._hsa04514 3 145 0.05568 0.2941
10 mTOR_signaling_pathway_hsa04150 3 151 0.06137 0.2941
11 Adherens_junction_hsa04520 2 72 0.06856 0.2941
12 Jak_STAT_signaling_pathway_hsa04630 3 162 0.07248 0.2941
13 cGMP_PKG_signaling_pathway_hsa04022 3 163 0.07353 0.2941
14 Neuroactive_ligand_receptor_interaction_hsa04080 4 278 0.0845 0.3139
15 Rap1_signaling_pathway_hsa04015 3 206 0.1247 0.4324
16 Sphingolipid_signaling_pathway_hsa04071 2 118 0.1559 0.4864
17 Apoptosis_hsa04210 2 138 0.1984 0.565
18 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.2173 0.565
19 Calcium_signaling_pathway_hsa04020 2 182 0.2949 0.7303

Quest ID: c7e13a7f8ca2fd4396f4a8ef5be95bdd