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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-181b-5p ABCA5 0.97 0 -1.08 0 mirMAP -0.32 0 NA
2 hsa-miR-181b-5p ABI1 0.97 0 -0.24 0.0098 MirTarget -0.24 0 NA
3 hsa-miR-181b-5p ACAD8 0.97 0 -1.04 0 MirTarget -0.15 3.0E-5 NA
4 hsa-miR-181b-5p ACAP2 0.97 0 0.11 0.40427 MirTarget; miRNATAP -0.28 0 NA
5 hsa-miR-181b-5p ACSL1 0.97 0 -1.24 0 MirTarget -0.41 0 NA
6 hsa-miR-181b-5p ACSL6 0.97 0 -1.41 0 miRNATAP -0.23 0.02086 NA
7 hsa-miR-181b-5p ACSS1 0.97 0 -0.09 0.62166 mirMAP -0.12 0.04826 NA
8 hsa-miR-181b-5p ACSS3 0.97 0 -2.16 0 MirTarget -0.21 0.04571 NA
9 hsa-miR-181b-5p ACVR2A 0.97 0 -0.89 0 MirTarget; miRNATAP -0.3 0 NA
10 hsa-miR-181b-5p ADAM11 0.97 0 -0.59 0.00626 MirTarget; miRNATAP -0.15 0.04789 NA
11 hsa-miR-181b-5p ADAM22 0.97 0 -0.46 0.16333 mirMAP; miRNATAP -0.36 0.00178 NA
12 hsa-miR-181b-5p ADARB2 0.97 0 -2.34 0 MirTarget -0.58 3.0E-5 NA
13 hsa-miR-181b-5p ADCY9 0.97 0 -0.39 0.00115 miRNATAP -0.11 0.01129 24269684 miR 181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 AC9 in cervical cancer cells; Phenotypic experiments indicated that miR-181b and AC9 exerted opposite effects on cell proliferation and apoptosis
14 hsa-miR-181b-5p AFF1 0.97 0 -0.59 0 mirMAP; miRNATAP -0.22 0 NA
15 hsa-miR-181b-5p AFF4 0.97 0 -0.51 1.0E-5 mirMAP; miRNATAP -0.13 0.00113 NA
16 hsa-miR-181b-5p AFG3L2 0.97 0 -0.24 0.00364 MirTarget; miRNATAP -0.17 0 NA
17 hsa-miR-181b-5p AFTPH 0.97 0 -0.31 2.0E-5 MirTarget; miRNATAP -0.2 0 NA
18 hsa-miR-181b-5p AGFG2 0.97 0 -1.89 0 mirMAP -0.39 0 NA
19 hsa-miR-181b-5p AGGF1 0.97 0 -0.19 0.00569 mirMAP -0.13 0 NA
20 hsa-miR-181b-5p AGPAT3 0.97 0 -0.73 0 MirTarget -0.13 0.00036 NA
21 hsa-miR-181b-5p AKR1C1 0.97 0 0.01 0.97742 mirMAP -0.66 0 NA
22 hsa-miR-181b-5p ANKRD12 0.97 0 -0.3 0.00352 mirMAP -0.22 0 NA
23 hsa-miR-181b-5p ANKRD13C 0.97 0 -0.14 0.02711 MirTarget -0.1 0 NA
24 hsa-miR-181b-5p ANXA11 0.97 0 -0.91 0 MirTarget; mirMAP -0.13 0.00019 NA
25 hsa-miR-181b-5p AP1G1 0.97 0 -0.25 0.00213 miRNATAP -0.16 0 NA
26 hsa-miR-181b-5p AR 0.97 0 -3.13 0 miRNATAP -0.75 0 NA
27 hsa-miR-181b-5p ARF6 0.97 0 -0.43 0 MirTarget -0.17 0 NA
28 hsa-miR-181b-5p ARFGEF2 0.97 0 -0.31 0.00443 MirTarget; miRNATAP -0.21 0 NA
29 hsa-miR-181b-5p ARHGAP12 0.97 0 -0.53 0 mirMAP -0.2 0 NA
30 hsa-miR-181b-5p ARHGAP19 0.97 0 0.08 0.41629 mirMAP -0.15 2.0E-5 NA
31 hsa-miR-181b-5p ARHGAP32 0.97 0 -0.97 0 mirMAP -0.31 0 NA
32 hsa-miR-181b-5p ARHGAP5 0.97 0 -0.43 0.00026 mirMAP -0.26 0 NA
33 hsa-miR-181b-5p ARHGEF3 0.97 0 -0.65 0 MirTarget -0.21 0 NA
34 hsa-miR-181b-5p ARID2 0.97 0 -0.05 0.59839 mirMAP -0.19 0 NA
35 hsa-miR-181b-5p ARL5A 0.97 0 -0.41 1.0E-5 MirTarget -0.2 0 NA
36 hsa-miR-181b-5p ARL5B 0.97 0 -0.22 0.1625 mirMAP -0.34 0 NA
37 hsa-miR-181b-5p ARNT2 0.97 0 -0.27 0.32592 miRNATAP -0.21 0.0274 NA
38 hsa-miR-181b-5p ARRDC3 0.97 0 -0.85 0 MirTarget; mirMAP; miRNATAP -0.24 0 NA
39 hsa-miR-181b-5p ASXL2 0.97 0 -0.29 0.17368 mirMAP -0.38 0 NA
40 hsa-miR-181b-5p ATE1 0.97 0 -0.65 2.0E-5 mirMAP -0.38 0 NA
41 hsa-miR-181b-5p ATF2 0.97 0 0.1 0.47373 mirMAP; miRNATAP -0.14 0.00584 NA
42 hsa-miR-181b-5p ATG2B 0.97 0 -0.26 0.00679 mirMAP -0.14 5.0E-5 NA
43 hsa-miR-181b-5p ATP11B 0.97 0 0.16 0.21286 MirTarget -0.25 0 NA
44 hsa-miR-181b-5p ATP1B1 0.97 0 -0.73 0 miRNATAP -0.3 0 NA
45 hsa-miR-181b-5p ATP2B1 0.97 0 0.59 1.0E-5 MirTarget; miRNATAP -0.14 0.00455 NA
46 hsa-miR-181b-5p ATP2B2 0.97 0 -3.43 0 MirTarget; miRNATAP -0.7 0 NA
47 hsa-miR-181b-5p ATP6V1C2 0.97 0 -1.07 0 MirTarget -0.26 2.0E-5 NA
48 hsa-miR-181b-5p ATP8A1 0.97 0 -1.66 0 MirTarget; miRNATAP -0.28 0.00063 NA
49 hsa-miR-181b-5p ATP8B1 0.97 0 -0.6 0.0002 miRNATAP -0.6 0 NA
50 hsa-miR-181b-5p ATRNL1 0.97 0 -1.25 0.00065 mirMAP -0.43 0.00115 NA
51 hsa-miR-181b-5p ATXN7 0.97 0 -0.5 0 MirTarget -0.21 0 NA
52 hsa-miR-181b-5p B3GALT5 0.97 0 -3.66 0 MirTarget -0.78 0 NA
53 hsa-miR-181b-5p B4GALT4 0.97 0 0.51 0.0022 mirMAP -0.25 3.0E-5 NA
54 hsa-miR-181b-5p BAG5 0.97 0 -0.33 0 mirMAP -0.14 0 NA
55 hsa-miR-181b-5p BANK1 0.97 0 -0.5 0.05631 MirTarget -0.22 0.01862 NA
56 hsa-miR-181b-5p BAZ2B 0.97 0 -0.73 0 miRNATAP -0.22 0 NA
57 hsa-miR-181b-5p BCL2 0.97 0 -0.91 1.0E-5 miRNAWalker2 validate; miRTarBase -0.37 0 25524579 Moreover we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression
58 hsa-miR-181b-5p BCL6 0.97 0 -0.43 0.00039 miRNATAP -0.35 0 NA
59 hsa-miR-181b-5p BCLAF1 0.97 0 -0.31 0 MirTarget; mirMAP; miRNATAP -0.11 0 NA
60 hsa-miR-181b-5p BHLHE40 0.97 0 -0.77 0 MirTarget; miRNATAP -0.27 0 NA
61 hsa-miR-181b-5p BIRC6 0.97 0 -0.15 0.18273 MirTarget; miRNATAP -0.18 0 NA
62 hsa-miR-181b-5p BMP2K 0.97 0 -0.02 0.8669 MirTarget -0.17 0.00094 NA
63 hsa-miR-181b-5p BMP3 0.97 0 -4.3 0 miRNATAP -1.14 0 NA
64 hsa-miR-181b-5p BPTF 0.97 0 -0.15 0.11807 miRNAWalker2 validate; miRNATAP -0.18 0 NA
65 hsa-miR-181b-5p BRD1 0.97 0 -0.19 0.01331 MirTarget -0.19 0 NA
66 hsa-miR-181b-5p BRWD1 0.97 0 -0.16 0.03245 MirTarget -0.11 8.0E-5 NA
67 hsa-miR-181b-5p BRWD3 0.97 0 -0.21 0.20442 mirMAP -0.27 0 NA
68 hsa-miR-181b-5p BTBD3 0.97 0 -0.16 0.11842 miRNATAP -0.11 0.00217 NA
69 hsa-miR-181b-5p C18orf25 0.97 0 -0.71 0 mirMAP -0.26 0 NA
70 hsa-miR-181b-5p C1orf116 0.97 0 -1.48 0 mirMAP -0.33 0.00018 NA
71 hsa-miR-181b-5p C21orf91 0.97 0 -0.06 0.66904 miRNATAP -0.15 0.00238 NA
72 hsa-miR-181b-5p C2orf69 0.97 0 -0.17 0.05394 miRNATAP -0.22 0 NA
73 hsa-miR-181b-5p C2orf88 0.97 0 -1.96 0 mirMAP -0.41 0 NA
74 hsa-miR-181b-5p CA13 0.97 0 -1.89 0 mirMAP -0.39 0 NA
75 hsa-miR-181b-5p CACNA2D1 0.97 0 -1.54 0.00017 mirMAP -0.75 0 NA
76 hsa-miR-181b-5p CACNA2D2 0.97 0 -1.39 0 miRNATAP -0.29 0.00025 NA
77 hsa-miR-181b-5p CACNB2 0.97 0 -0.72 7.0E-5 miRNATAP -0.15 0.01851 NA
78 hsa-miR-181b-5p CACNB4 0.97 0 -3.54 0 mirMAP -0.75 0 NA
79 hsa-miR-181b-5p CALB1 0.97 0 4.4 0 MirTarget -0.46 0.04225 NA
80 hsa-miR-181b-5p CALCRL 0.97 0 -0.35 0.05963 MirTarget -0.24 0.00038 NA
81 hsa-miR-181b-5p CAMK2G 0.97 0 -0.24 0.0014 miRNATAP -0.1 0.00014 NA
82 hsa-miR-181b-5p CAMSAP1 0.97 0 -0.48 0 mirMAP; miRNATAP -0.21 0 NA
83 hsa-miR-181b-5p CAMTA2 0.97 0 -0.44 0 MirTarget -0.12 0 NA
84 hsa-miR-181b-5p CASKIN1 0.97 0 -0.27 0.38859 mirMAP -0.43 0.00012 NA
85 hsa-miR-181b-5p CAT 0.97 0 -0.74 0 miRNAWalker2 validate -0.13 0.00459 NA
86 hsa-miR-181b-5p CBFA2T2 0.97 0 0.2 0.05841 miRNATAP -0.11 0.00493 NA
87 hsa-miR-181b-5p CBLL1 0.97 0 0.05 0.54894 MirTarget -0.14 0 NA
88 hsa-miR-181b-5p CBX7 0.97 0 -1.23 0 miRNAWalker2 validate; miRTarBase; MirTarget; miRNATAP -0.42 0 NA
89 hsa-miR-181b-5p CCDC117 0.97 0 0.24 0.00518 MirTarget -0.14 0 NA
90 hsa-miR-181b-5p CCDC6 0.97 0 -0.75 0 mirMAP; miRNATAP -0.2 0 NA
91 hsa-miR-181b-5p CCDC85A 0.97 0 -1.79 0 mirMAP; miRNATAP -0.36 0.00019 NA
92 hsa-miR-181b-5p CCNG2 0.97 0 -1.02 0 mirMAP -0.17 0.00026 NA
93 hsa-miR-181b-5p CD46 0.97 0 -0.25 0.01424 mirMAP -0.16 0 NA
94 hsa-miR-181b-5p CDKN2AIP 0.97 0 -0.92 0 MirTarget -0.27 0 NA
95 hsa-miR-181b-5p CDON 0.97 0 -1.35 0 MirTarget -0.34 0 NA
96 hsa-miR-181b-5p CEP350 0.97 0 -0.21 0.0185 mirMAP -0.2 0 NA
97 hsa-miR-181b-5p CHD9 0.97 0 -0.33 0.00384 miRNATAP -0.18 1.0E-5 NA
98 hsa-miR-181b-5p CHL1 0.97 0 -3.25 0 MirTarget -1.06 0 NA
99 hsa-miR-181b-5p CHMP1B 0.97 0 -0.26 0.00727 MirTarget -0.12 0.00039 NA
100 hsa-miR-181b-5p CHMP2B 0.97 0 -0.63 0 MirTarget -0.16 0 NA
101 hsa-miR-181b-5p CLCN5 0.97 0 -0.14 0.21209 mirMAP -0.17 1.0E-5 NA
102 hsa-miR-181b-5p CLIP1 0.97 0 -0.81 0 MirTarget; miRNATAP -0.29 0 NA
103 hsa-miR-181b-5p CLN8 0.97 0 -0.81 0 MirTarget -0.29 0 NA
104 hsa-miR-181b-5p CLOCK 0.97 0 -0.79 0 mirMAP -0.33 0 NA
105 hsa-miR-181b-5p CMTM6 0.97 0 -0.21 0.03504 mirMAP -0.13 0.00011 NA
106 hsa-miR-181b-5p CNKSR2 0.97 0 -1.15 0.00039 MirTarget; miRNATAP -0.45 0.00011 NA
107 hsa-miR-181b-5p CNKSR3 0.97 0 -0.86 0 MirTarget -0.4 0 NA
108 hsa-miR-181b-5p CNR1 0.97 0 -1.55 0 mirMAP -0.46 0.00013 NA
109 hsa-miR-181b-5p CNST 0.97 0 -0.31 0.00061 mirMAP -0.18 0 NA
110 hsa-miR-181b-5p CNTN4 0.97 0 -1.88 0 miRNATAP -0.49 5.0E-5 NA
111 hsa-miR-181b-5p COBL 0.97 0 -3.73 0 mirMAP -0.66 0 NA
112 hsa-miR-181b-5p COG5 0.97 0 -0.26 0.00073 mirMAP -0.14 0 NA
113 hsa-miR-181b-5p CPD 0.97 0 -0.26 0.02865 MirTarget; miRNATAP -0.17 3.0E-5 NA
114 hsa-miR-181b-5p CPEB4 0.97 0 -1.56 0 miRNATAP -0.4 0 NA
115 hsa-miR-181b-5p CREB3L2 0.97 0 -0.27 0.03509 mirMAP -0.14 0.00319 NA
116 hsa-miR-181b-5p CTDSPL 0.97 0 -0.43 0 MirTarget; miRNATAP -0.12 0.00017 NA
117 hsa-miR-181b-5p CTNNA1 0.97 0 -0.53 0 MirTarget -0.12 2.0E-5 NA
118 hsa-miR-181b-5p CTTNBP2 0.97 0 -3.28 0 miRNATAP -0.86 0 NA
119 hsa-miR-181b-5p CTTNBP2NL 0.97 0 -0.29 0.00687 MirTarget; miRNATAP -0.19 0 NA
120 hsa-miR-181b-5p CUL3 0.97 0 -0.78 0 mirMAP; miRNATAP -0.21 0 NA
121 hsa-miR-181b-5p CUL5 0.97 0 -0.53 0 miRNATAP -0.12 6.0E-5 NA
122 hsa-miR-181b-5p CXADR 0.97 0 -0.32 0.17503 miRNATAP -0.45 0 NA
123 hsa-miR-181b-5p CYP4F3 0.97 0 -1.49 0.00065 mirMAP -1.24 0 NA
124 hsa-miR-181b-5p DAAM1 0.97 0 -0.37 0.02951 mirMAP -0.18 0.00414 NA
125 hsa-miR-181b-5p DCUN1D1 0.97 0 0.21 0.06177 MirTarget; mirMAP -0.15 0.00021 NA
126 hsa-miR-181b-5p DDX21 0.97 0 -0.04 0.81656 mirMAP -0.19 0.00235 NA
127 hsa-miR-181b-5p DDX3X 0.97 0 -0.43 2.0E-5 miRNATAP -0.16 0 NA
128 hsa-miR-181b-5p DENND1B 0.97 0 -0.29 0.05162 mirMAP -0.22 2.0E-5 NA
129 hsa-miR-181b-5p DENND4C 0.97 0 -0.71 0 MirTarget -0.21 0 NA
130 hsa-miR-181b-5p DGKB 0.97 0 -1.26 0.00016 mirMAP -0.34 0.00396 NA
131 hsa-miR-181b-5p DGKH 0.97 0 0.25 0.10803 MirTarget -0.19 0.00087 NA
132 hsa-miR-181b-5p DIP2B 0.97 0 0.43 0.00072 MirTarget; miRNATAP -0.14 0.00163 NA
133 hsa-miR-181b-5p DISC1 0.97 0 -0.01 0.97413 mirMAP -0.14 0.02301 NA
134 hsa-miR-181b-5p DNAH3 0.97 0 -0.3 0.19633 mirMAP -0.26 0.00187 NA
135 hsa-miR-181b-5p DNAJA4 0.97 0 -0.95 0 MirTarget -0.26 0 NA
136 hsa-miR-181b-5p DNAJC27 0.97 0 -0.33 0.00024 mirMAP -0.14 2.0E-5 NA
137 hsa-miR-181b-5p DPP10 0.97 0 -2.01 0 mirMAP; miRNATAP -0.53 2.0E-5 NA
138 hsa-miR-181b-5p DTNA 0.97 0 -1.89 0 mirMAP -0.26 0.02721 NA
139 hsa-miR-181b-5p DUSP28 0.97 0 -0.72 0 mirMAP -0.13 0.00054 NA
140 hsa-miR-181b-5p EAF1 0.97 0 -0.3 0.00433 mirMAP -0.17 0 NA
141 hsa-miR-181b-5p EEA1 0.97 0 -0.75 0 mirMAP -0.21 0 NA
142 hsa-miR-181b-5p EGLN1 0.97 0 -0.66 0 mirMAP -0.23 0 NA
143 hsa-miR-181b-5p EGR1 0.97 0 -1.69 0 miRNATAP -0.25 0.0009 NA
144 hsa-miR-181b-5p EGR3 0.97 0 -0.96 5.0E-5 mirMAP -0.17 0.04936 NA
145 hsa-miR-181b-5p EIF4A2 0.97 0 -0.02 0.87495 MirTarget; miRNATAP -0.11 0.00757 NA
146 hsa-miR-181b-5p ELK4 0.97 0 0.36 0.00595 mirMAP -0.14 0.00256 NA
147 hsa-miR-181b-5p ELOVL6 0.97 0 -1.15 0 mirMAP -0.18 0.00747 NA
148 hsa-miR-181b-5p EMP2 0.97 0 -0.65 0 mirMAP -0.39 0 NA
149 hsa-miR-181b-5p EP300 0.97 0 -0.04 0.77828 miRNAWalker2 validate -0.25 0 NA
150 hsa-miR-181b-5p EPB41L3 0.97 0 -1.36 0 MirTarget -0.28 5.0E-5 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 PHOSPHATE CONTAINING COMPOUND METABOLIC PROCESS 99 1977 1.92e-11 8.933e-08
2 PROTEIN PHOSPHORYLATION 54 944 1.811e-08 4.213e-05
3 PHOSPHORYLATION 63 1228 6.392e-08 9.913e-05
4 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 54 1008 1.562e-07 0.0001817
5 CELLULAR RESPONSE TO HORMONE STIMULUS 35 552 6.467e-07 0.0006018
6 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 78 1784 1.119e-06 0.0008675
7 REGULATION OF SMALL GTPASE MEDIATED SIGNAL TRANSDUCTION 22 278 2.521e-06 0.001676
8 RESPONSE TO HORMONE 46 893 3.926e-06 0.002284
9 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 71 1656 7.171e-06 0.003707
10 INTRACELLULAR SIGNAL TRANSDUCTION 68 1572 8.579e-06 0.003992
11 SINGLE ORGANISM BEHAVIOR 25 384 1.677e-05 0.006503
12 RESPONSE TO ENDOGENOUS STIMULUS 63 1450 1.667e-05 0.006503
13 TISSUE DEVELOPMENT 65 1518 1.906e-05 0.006821
14 RHYTHMIC PROCESS 21 298 2.491e-05 0.008278
15 POSITIVE REGULATION OF MOLECULAR FUNCTION 73 1791 2.922e-05 0.009063
NumGOOverlapSizeP ValueAdj. P Value
1 KINASE ACTIVITY 50 842 1.956e-08 1.818e-05
2 ZINC ION BINDING 59 1155 2.025e-07 9.404e-05
3 PROTEIN KINASE ACTIVITY 38 640 1.071e-06 0.0003316
4 ENZYME BINDING 76 1737 1.529e-06 0.0003552
5 TRANSITION METAL ION BINDING 64 1400 2.785e-06 0.0003696
6 ADENYL NUCLEOTIDE BINDING 68 1514 2.417e-06 0.0003696
7 TRANSFERASE ACTIVITY TRANSFERRING PHOSPHORUS CONTAINING GROUPS 50 992 2.703e-06 0.0003696
8 PROTEIN SERINE THREONINE KINASE ACTIVITY 29 445 3.507e-06 0.0004073
9 RIBONUCLEOTIDE BINDING 78 1860 5.372e-06 0.0005545
10 PROTEIN DOMAIN SPECIFIC BINDING 34 624 2.421e-05 0.002249
11 MOLECULAR FUNCTION REGULATOR 58 1353 5.403e-05 0.004563
12 STEROID HORMONE RECEPTOR ACTIVITY 8 59 0.0001118 0.008659
NumGOOverlapSizeP ValueAdj. P Value
1 EXCITATORY SYNAPSE 17 197 1.126e-05 0.006577
2 ENDOSOMAL PART 26 430 4.045e-05 0.007874
3 ENDOSOME 40 793 2.757e-05 0.007874

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 20 295 6.637e-05 0.003451
2 FoxO_signaling_pathway_hsa04068 11 132 0.0005293 0.01376
3 Phospholipase_D_signaling_pathway_hsa04072 11 146 0.001222 0.02118
4 AMPK_signaling_pathway_hsa04152 9 121 0.003614 0.03978
5 HIF_1_signaling_pathway_hsa04066 8 100 0.003825 0.03978
6 mTOR_signaling_pathway_hsa04150 10 151 0.005082 0.04405
7 cGMP_PKG_signaling_pathway_hsa04022 10 163 0.008571 0.05571
8 Endocytosis_hsa04144 13 244 0.009398 0.05571
9 Adherens_junction_hsa04520 6 72 0.009643 0.05571
10 cAMP_signaling_pathway_hsa04024 11 198 0.01213 0.06019
11 Phosphatidylinositol_signaling_system_hsa04070 7 99 0.01273 0.06019
12 Ras_signaling_pathway_hsa04014 12 232 0.01523 0.06599
13 TNF_signaling_pathway_hsa04668 7 108 0.0197 0.07882
14 Oocyte_meiosis_hsa04114 7 124 0.03797 0.141
15 Autophagy_animal_hsa04140 7 128 0.04385 0.152
16 Apelin_signaling_pathway_hsa04371 7 137 0.05912 0.1755
17 TGF_beta_signaling_pathway_hsa04350 5 84 0.0614 0.1755
18 ErbB_signaling_pathway_hsa04012 5 85 0.06395 0.1755
19 PI3K_Akt_signaling_pathway_hsa04151 14 352 0.06412 0.1755
20 Cellular_senescence_hsa04218 7 160 0.1114 0.2852
21 Hedgehog_signaling_pathway_hsa04340 3 47 0.1152 0.2852
22 Notch_signaling_pathway_hsa04330 3 48 0.1207 0.2852
23 Tight_junction_hsa04530 7 170 0.1398 0.3043
24 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 6 139 0.1404 0.3043
25 Rap1_signaling_pathway_hsa04015 8 206 0.1516 0.3153
26 Peroxisome_hsa04146 4 83 0.158 0.316
27 Wnt_signaling_pathway_hsa04310 6 146 0.1649 0.3175
28 Calcium_signaling_pathway_hsa04020 7 182 0.1781 0.3202
29 Sphingolipid_signaling_pathway_hsa04071 5 118 0.1786 0.3202
30 Hippo_signaling_pathway_hsa04390 6 154 0.1948 0.3377
31 Apoptosis_multiple_species_hsa04215 2 33 0.2023 0.3394
32 Jak_STAT_signaling_pathway_hsa04630 6 162 0.2267 0.3684
33 Focal_adhesion_hsa04510 7 199 0.2388 0.3764
34 Ferroptosis_hsa04216 2 40 0.2679 0.4062
35 Regulation_of_actin_cytoskeleton_hsa04810 7 208 0.2734 0.4062
36 Cell_adhesion_molecules_.CAMs._hsa04514 5 145 0.3042 0.4394
37 Necroptosis_hsa04217 5 164 0.3991 0.5609
38 VEGF_signaling_pathway_hsa04370 2 59 0.4411 0.6036
39 Cell_cycle_hsa04110 3 124 0.6094 0.7728
40 Gap_junction_hsa04540 2 88 0.6552 0.8041
41 Apoptosis_hsa04210 3 138 0.6808 0.8041
42 NF_kappa_B_signaling_pathway_hsa04064 2 95 0.6959 0.8041
43 Phagosome_hsa04145 3 152 0.742 0.8388
44 Neuroactive_ligand_receptor_interaction_hsa04080 4 278 0.9233 0.9602
45 Cytokine_cytokine_receptor_interaction_hsa04060 3 270 0.9684 0.9684

Quest ID: cf69e49c5d38c866c7cc27b741cb2630