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This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-361-5p ABCA1 0.01 0.9852 0.72 0.28064 miRanda; mirMAP -0.35 0.00124 NA
2 hsa-miR-361-5p ABCD2 0.01 0.9852 -2.82 0.00416 miRanda -0.35 0.03211 NA
3 hsa-miR-361-3p ABCG4 0.81 0.04185 -0.87 0.36278 MirTarget; mirMAP -0.63 0 NA
4 hsa-miR-361-3p ACAN 0.81 0.04185 -0.27 0.79599 PITA -0.56 0.00016 NA
5 hsa-miR-361-3p ADAM19 0.81 0.04185 0.44 0.52629 mirMAP -0.23 0.02461 NA
6 hsa-miR-361-3p ADAMTS14 0.81 0.04185 1.55 0.06914 mirMAP -0.45 0.00026 NA
7 hsa-miR-361-3p ADARB1 0.81 0.04185 -2.48 1.0E-5 MirTarget -0.24 0.00409 NA
8 hsa-miR-361-3p AFAP1 0.81 0.04185 -0.7 0.18292 mirMAP -0.18 0.01719 NA
9 hsa-miR-361-3p AGAP3 0.81 0.04185 -0.6 0.12108 miRNATAP -0.16 0.00393 NA
10 hsa-miR-361-5p AHNAK 0.01 0.9852 -1.19 0.03091 miRanda -0.31 0.0007 NA
11 hsa-miR-361-3p AIF1L 0.81 0.04185 -0.72 0.37107 mirMAP -0.26 0.02559 NA
12 hsa-miR-361-3p AJAP1 0.81 0.04185 -2.49 0.05813 MirTarget; PITA; miRNATAP -0.59 0.00191 NA
13 hsa-miR-361-5p AJAP1 0.01 0.9852 -2.49 0.05813 miRanda -0.52 0.01646 NA
14 hsa-miR-361-3p ALDH3B2 0.81 0.04185 5.97 0 MirTarget -0.39 0.03712 NA
15 hsa-miR-361-3p ANKH 0.81 0.04185 -0.63 0.36736 mirMAP -0.43 1.0E-5 NA
16 hsa-miR-361-5p ANKLE2 0.01 0.9852 0.89 0.00209 miRanda -0.19 8.0E-5 NA
17 hsa-miR-361-3p ANKRD13B 0.81 0.04185 -0.09 0.88698 PITA -0.5 0 NA
18 hsa-miR-361-3p ANKRD27 0.81 0.04185 0.53 0.12671 mirMAP -0.18 0.0003 NA
19 hsa-miR-361-5p ANKRD28 0.01 0.9852 -0.22 0.47325 miRanda -0.1 0.04545 NA
20 hsa-miR-361-5p ANKRD34B 0.01 0.9852 5.38 0.00131 MirTarget; miRanda -0.67 0.01615 NA
21 hsa-miR-361-3p ANKRD50 0.81 0.04185 -0.02 0.97181 miRNATAP -0.18 0.02184 NA
22 hsa-miR-361-3p ANKRD52 0.81 0.04185 0.56 0.10701 PITA; miRNATAP -0.13 0.01234 NA
23 hsa-miR-361-5p ANO6 0.01 0.9852 -1.42 0.00017 MirTarget; miRanda -0.16 0.01214 NA
24 hsa-miR-361-3p ANTXR2 0.81 0.04185 -4.25 0 miRNATAP -0.36 0.00293 NA
25 hsa-miR-361-5p AOC3 0.01 0.9852 -5.56 0 MirTarget; miRanda -0.33 0.02297 NA
26 hsa-miR-361-5p AP3B1 0.01 0.9852 0.44 0.09958 miRanda -0.11 0.01335 NA
27 hsa-miR-361-3p APLN 0.81 0.04185 1.76 0.12642 mirMAP -0.38 0.02482 NA
28 hsa-miR-361-3p APP 0.81 0.04185 -0.56 0.22421 miRNATAP -0.25 0.00013 NA
29 hsa-miR-361-5p AQP9 0.01 0.9852 1.35 0.24925 miRanda -0.44 0.02327 NA
30 hsa-miR-361-5p ARGLU1 0.01 0.9852 0.31 0.38739 MirTarget; miRanda; miRNATAP -0.18 0.00308 NA
31 hsa-miR-361-5p ARHGAP15 0.01 0.9852 -0.7 0.44662 miRanda -0.37 0.01414 NA
32 hsa-miR-361-5p ARHGAP21 0.01 0.9852 -0.14 0.76187 miRanda -0.15 0.04148 NA
33 hsa-miR-361-5p ARHGAP9 0.01 0.9852 0.96 0.22755 miRanda -0.49 0.00016 NA
34 hsa-miR-361-3p ARHGEF10 0.81 0.04185 -1.41 0.0117 miRNATAP -0.36 1.0E-5 NA
35 hsa-miR-361-5p ARHGEF37 0.01 0.9852 -0.75 0.26489 miRanda; miRNATAP -0.38 0.00066 NA
36 hsa-miR-361-3p ARNT 0.81 0.04185 -0.69 0.00574 PITA -0.12 0.00085 NA
37 hsa-miR-361-5p ARRDC2 0.01 0.9852 -0.44 0.33773 miRanda -0.28 0.00025 NA
38 hsa-miR-361-3p ASAP3 0.81 0.04185 -0.92 0.12799 MirTarget -0.19 0.03311 NA
39 hsa-miR-361-5p ASB7 0.01 0.9852 0.15 0.57293 miRanda -0.12 0.00602 NA
40 hsa-miR-361-5p ATP10B 0.01 0.9852 3.53 0.02777 miRanda -0.55 0.03794 NA
41 hsa-miR-361-5p ATP8B4 0.01 0.9852 -2.31 0.00034 miRanda -0.3 0.0048 NA
42 hsa-miR-361-3p ATXN1L 0.81 0.04185 -0.23 0.57695 miRNATAP -0.17 0.00364 NA
43 hsa-miR-361-5p AXL 0.01 0.9852 -2.16 0.00936 miRanda -0.3 0.0281 NA
44 hsa-miR-361-5p B2M 0.01 0.9852 0.05 0.93778 miRanda -0.52 0 NA
45 hsa-miR-361-5p BACH1 0.01 0.9852 0.1 0.82342 miRanda; mirMAP -0.23 0.00237 NA
46 hsa-miR-361-3p BCL9L 0.81 0.04185 -0.12 0.78985 mirMAP -0.14 0.02794 NA
47 hsa-miR-361-3p BCORL1 0.81 0.04185 -0.77 0.104 MirTarget; miRNATAP -0.19 0.00563 NA
48 hsa-miR-361-3p BEST4 0.81 0.04185 -0.36 0.68509 miRNATAP -0.27 0.03379 NA
49 hsa-miR-361-5p BIVM 0.01 0.9852 -0.76 0.04739 miRanda -0.14 0.0249 NA
50 hsa-miR-361-5p BLZF1 0.01 0.9852 0.69 0.06799 miRanda -0.2 0.00158 NA
51 hsa-miR-361-5p BNIP2 0.01 0.9852 -0.41 0.18881 mirMAP -0.12 0.0248 NA
52 hsa-miR-361-3p BRSK2 0.81 0.04185 -2.21 0.07988 mirMAP -0.38 0.0377 NA
53 hsa-miR-361-3p BSN 0.81 0.04185 -0.69 0.40814 mirMAP -0.25 0.03499 NA
54 hsa-miR-361-5p BTLA 0.01 0.9852 1.19 0.19794 miRanda -0.31 0.04489 NA
55 hsa-miR-361-5p BTN2A1 0.01 0.9852 -0.64 0.11011 miRanda -0.16 0.01669 NA
56 hsa-miR-361-3p C15orf52 0.81 0.04185 -1.2 0.18499 mirMAP -0.51 8.0E-5 NA
57 hsa-miR-361-3p C17orf51 0.81 0.04185 -1.61 0.06048 mirMAP -0.34 0.00648 NA
58 hsa-miR-361-5p C1orf21 0.01 0.9852 -1.27 0.0681 mirMAP -0.29 0.01125 NA
59 hsa-miR-361-3p CACNA1C 0.81 0.04185 -5.48 0 MirTarget -0.42 0.00098 NA
60 hsa-miR-361-3p CACNA1H 0.81 0.04185 -5.97 0 MirTarget; mirMAP -0.43 0.00276 NA
61 hsa-miR-361-3p CACNB3 0.81 0.04185 -0.86 0.02833 mirMAP -0.21 0.00016 NA
62 hsa-miR-361-3p CADM4 0.81 0.04185 0.29 0.64464 miRNATAP -0.26 0.00464 NA
63 hsa-miR-361-5p CALCOCO2 0.01 0.9852 -0.58 0.02461 miRNAWalker2 validate; miRanda -0.12 0.00432 NA
64 hsa-miR-361-3p CALN1 0.81 0.04185 -3 0.04497 mirMAP -0.54 0.0132 NA
65 hsa-miR-361-3p CAMK2A 0.81 0.04185 -4.61 0.0001 mirMAP -0.68 8.0E-5 NA
66 hsa-miR-361-5p CASP1 0.01 0.9852 0.88 0.27422 miRanda -0.51 0.00011 NA
67 hsa-miR-361-5p CASP10 0.01 0.9852 0.7 0.33671 miRanda -0.46 0.00011 NA
68 hsa-miR-361-5p CASP4 0.01 0.9852 0.7 0.18713 miRanda -0.34 8.0E-5 NA
69 hsa-miR-361-5p CASP7 0.01 0.9852 0.55 0.21498 PITA; miRanda -0.2 0.00762 NA
70 hsa-miR-361-3p CAV1 0.81 0.04185 -3.38 0.00041 miRNATAP -0.56 6.0E-5 NA
71 hsa-miR-361-5p CAV2 0.01 0.9852 -1.14 0.15869 miRanda -0.3 0.02263 NA
72 hsa-miR-361-3p CBX6 0.81 0.04185 -1.63 0.03183 mirMAP -0.26 0.01959 NA
73 hsa-miR-361-5p CCDC6 0.01 0.9852 -0.12 0.7292 miRanda -0.18 0.00219 NA
74 hsa-miR-361-5p CCDC68 0.01 0.9852 -1.22 0.30525 miRanda -0.52 0.00841 NA
75 hsa-miR-361-3p CCDC85B 0.81 0.04185 -1.26 0.04647 miRNATAP -0.19 0.04071 NA
76 hsa-miR-361-5p CCDC88B 0.01 0.9852 1.52 0.02257 miRanda -0.33 0.00311 NA
77 hsa-miR-361-5p CCNDBP1 0.01 0.9852 -0.58 0.07212 MirTarget; miRanda -0.19 0.00033 NA
78 hsa-miR-361-5p CCR6 0.01 0.9852 0.66 0.33587 miRanda -0.28 0.01605 NA
79 hsa-miR-361-5p CD160 0.01 0.9852 -0.98 0.17699 miRanda -0.25 0.04094 NA
80 hsa-miR-361-5p CD40 0.01 0.9852 -0.59 0.49568 miRanda -0.31 0.03376 NA
81 hsa-miR-361-5p CD46 0.01 0.9852 0.75 0.04358 miRNAWalker2 validate -0.15 0.0135 NA
82 hsa-miR-361-5p CD48 0.01 0.9852 0.13 0.8812 miRanda -0.35 0.01674 NA
83 hsa-miR-361-5p CD55 0.01 0.9852 -0.72 0.44894 miRanda -0.36 0.02431 NA
84 hsa-miR-361-3p CDC42BPB 0.81 0.04185 -0.18 0.61556 MirTarget; PITA; miRNATAP -0.22 2.0E-5 NA
85 hsa-miR-361-3p CDH2 0.81 0.04185 -1.61 0.25907 miRNATAP -0.96 0 NA
86 hsa-miR-361-5p CDK7 0.01 0.9852 0.58 0.07443 miRanda -0.13 0.0149 NA
87 hsa-miR-361-3p CDS2 0.81 0.04185 -0.58 0.05025 miRNATAP -0.12 0.00362 NA
88 hsa-miR-361-5p CEACAM1 0.01 0.9852 1.88 0.04777 miRanda -0.46 0.00359 NA
89 hsa-miR-361-5p CEACAM3 0.01 0.9852 1 0.35925 miRanda -0.38 0.03715 NA
90 hsa-miR-361-3p CELF1 0.81 0.04185 0.18 0.60295 mirMAP -0.14 0.00366 NA
91 hsa-miR-361-5p CELF6 0.01 0.9852 -1.7 0.01433 miRanda -0.28 0.01358 NA
92 hsa-miR-361-3p CHD5 0.81 0.04185 -1.82 0.0717 mirMAP -0.29 0.04718 NA
93 hsa-miR-361-5p CHMP5 0.01 0.9852 0.26 0.37516 miRanda -0.17 0.00043 NA
94 hsa-miR-361-3p CHPF 0.81 0.04185 -0.76 0.17066 miRNATAP -0.19 0.01981 NA
95 hsa-miR-361-5p CHST11 0.01 0.9852 0.01 0.99092 miRanda -0.5 0.00024 NA
96 hsa-miR-361-3p CHST8 0.81 0.04185 -3.12 0.02337 mirMAP -0.54 0.00743 NA
97 hsa-miR-361-5p CLCN1 0.01 0.9852 0.51 0.7222 miRanda -0.57 0.01618 NA
98 hsa-miR-361-5p CLCN6 0.01 0.9852 -1.29 3.0E-5 miRanda -0.11 0.02984 NA
99 hsa-miR-361-3p CLDN1 0.81 0.04185 0.72 0.60915 MirTarget -0.42 0.03711 NA
100 hsa-miR-361-5p CLEC7A 0.01 0.9852 2.17 0.05908 miRanda -0.42 0.02907 NA
101 hsa-miR-361-5p CLIP4 0.01 0.9852 -0.83 0.29386 miRanda -0.27 0.03762 NA
102 hsa-miR-361-5p CLPX 0.01 0.9852 0.23 0.47638 PITA; miRanda -0.15 0.00568 NA
103 hsa-miR-361-5p CMPK2 0.01 0.9852 1.57 0.063 miRanda -0.64 0 NA
104 hsa-miR-361-5p CNDP2 0.01 0.9852 0.66 0.06406 miRanda -0.17 0.00303 NA
105 hsa-miR-361-3p CNNM1 0.81 0.04185 -1.68 0.30911 miRNATAP -0.54 0.02561 NA
106 hsa-miR-361-5p COBL 0.01 0.9852 1.03 0.58085 miRanda -0.7 0.0245 NA
107 hsa-miR-361-3p COL1A1 0.81 0.04185 -1.84 0.04283 PITA -0.55 2.0E-5 NA
108 hsa-miR-361-5p CR1 0.01 0.9852 -1.54 0.1441 MirTarget; miRanda -0.46 0.00845 NA
109 hsa-miR-361-5p CSAD 0.01 0.9852 0.56 0.26569 miRanda -0.27 0.00131 NA
110 hsa-miR-361-5p CSF3R 0.01 0.9852 0.32 0.72354 miRanda -0.61 3.0E-5 NA
111 hsa-miR-361-3p CTGF 0.81 0.04185 -4.34 2.0E-5 MirTarget; miRNATAP -0.33 0.02483 NA
112 hsa-miR-361-5p CTNND1 0.01 0.9852 0.95 0.02378 PITA; miRanda; mirMAP; miRNATAP -0.23 0.00115 NA
113 hsa-miR-361-5p CYB5R4 0.01 0.9852 0.99 0.01022 miRanda -0.2 0.00206 NA
114 hsa-miR-361-3p DAAM2 0.81 0.04185 -4.26 1.0E-5 mirMAP -0.67 0 NA
115 hsa-miR-361-5p DAPK1 0.01 0.9852 -0.96 0.32638 miRanda -0.39 0.01615 NA
116 hsa-miR-361-5p DAPP1 0.01 0.9852 0.98 0.20615 miRanda -0.34 0.00751 NA
117 hsa-miR-361-5p DCBLD1 0.01 0.9852 1.56 0.00214 miRanda -0.23 0.00655 NA
118 hsa-miR-361-5p DDX60L 0.01 0.9852 0.71 0.27585 miRanda -0.42 8.0E-5 NA
119 hsa-miR-361-5p DENND4C 0.01 0.9852 -0.63 0.08993 miRanda -0.13 0.03068 NA
120 hsa-miR-361-5p DIO2 0.01 0.9852 1.67 0.11486 miRanda; mirMAP -0.42 0.01637 NA
121 hsa-miR-361-5p DIP2A 0.01 0.9852 0.42 0.22203 miRanda -0.13 0.01783 NA
122 hsa-miR-361-3p DLST 0.81 0.04185 -0.13 0.65181 miRNATAP -0.11 0.00645 NA
123 hsa-miR-361-5p DNAH5 0.01 0.9852 3 0.03389 miRanda -0.5 0.03444 NA
124 hsa-miR-361-5p DNAJA1 0.01 0.9852 0.46 0.21378 miRanda -0.13 0.0293 NA
125 hsa-miR-361-5p DNHD1 0.01 0.9852 -0.11 0.84747 miRanda -0.18 0.04475 NA
126 hsa-miR-361-3p DNM3 0.81 0.04185 -2.57 0.00056 MirTarget -0.33 0.00221 NA
127 hsa-miR-361-5p DOCK5 0.01 0.9852 1.66 0.02457 miRanda -0.27 0.02681 NA
128 hsa-miR-361-5p DOCK6 0.01 0.9852 -0.19 0.65021 miRNAWalker2 validate -0.31 1.0E-5 NA
129 hsa-miR-361-5p DOCK8 0.01 0.9852 1.18 0.08204 miRanda -0.39 0.00055 NA
130 hsa-miR-361-5p DOCK9 0.01 0.9852 -0.14 0.78975 miRanda -0.21 0.01416 NA
131 hsa-miR-361-5p DPF3 0.01 0.9852 0.63 0.47122 PITA; miRanda -0.43 0.00309 NA
132 hsa-miR-361-5p DPH3 0.01 0.9852 -0.63 0.03801 miRanda -0.1 0.04107 NA
133 hsa-miR-361-5p DSE 0.01 0.9852 0.32 0.59614 miRanda -0.3 0.00216 NA
134 hsa-miR-361-3p DSTYK 0.81 0.04185 -0.94 0.00369 miRNATAP -0.24 0 NA
135 hsa-miR-361-5p DUSP10 0.01 0.9852 1.14 0.0681 miRanda -0.24 0.02091 NA
136 hsa-miR-361-3p DUSP9 0.81 0.04185 6.66 4.0E-5 mirMAP -0.47 0.04821 NA
137 hsa-miR-361-3p EDA 0.81 0.04185 -2.77 0.01671 MirTarget -0.39 0.02086 NA
138 hsa-miR-361-3p EFNA3 0.81 0.04185 2.44 0.00286 MirTarget; miRNATAP -0.42 0.00042 NA
139 hsa-miR-361-3p EHMT2 0.81 0.04185 -0.01 0.98317 miRNATAP -0.11 0.0124 NA
140 hsa-miR-361-5p EIF2AK2 0.01 0.9852 1.75 9.0E-5 miRanda -0.18 0.01512 NA
141 hsa-miR-361-5p ELF1 0.01 0.9852 0.17 0.71941 miRanda -0.19 0.01318 NA
142 hsa-miR-361-5p ELK3 0.01 0.9852 -0.79 0.2934 miRanda -0.32 0.01115 NA
143 hsa-miR-361-5p ELL 0.01 0.9852 -0.52 0.05507 miRanda -0.15 0.00067 NA
144 hsa-miR-361-5p ELOVL7 0.01 0.9852 1.07 0.08286 PITA; miRanda; miRNATAP -0.21 0.04182 NA
145 hsa-miR-361-5p EMB 0.01 0.9852 1.23 0.17726 miRanda -0.52 0.00063 NA
146 hsa-miR-361-3p EMP1 0.81 0.04185 -0.59 0.51763 MirTarget -0.46 0.00039 NA
147 hsa-miR-361-3p ENTPD3 0.81 0.04185 0.27 0.80264 MirTarget -0.44 0.00504 NA
148 hsa-miR-361-3p EP300 0.81 0.04185 0.22 0.57893 PITA -0.14 0.02008 NA
149 hsa-miR-361-5p EPAS1 0.01 0.9852 -1.28 0.03116 miRanda -0.3 0.00241 NA
150 hsa-miR-361-5p EPB41L4A 0.01 0.9852 -0.08 0.89089 miRanda -0.33 0.0005 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
1 IMMUNE SYSTEM PROCESS 102 1984 7.733e-15 3.598e-11
2 REGULATION OF IMMUNE SYSTEM PROCESS 76 1403 3.371e-12 7.842e-09
3 IMMUNE RESPONSE 61 1100 2.473e-10 3.835e-07
4 CELLULAR RESPONSE TO ORGANIC SUBSTANCE 85 1848 6.754e-10 7.856e-07
5 POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS 51 867 1.171e-09 1.09e-06
6 REGULATION OF IMMUNE RESPONSE 50 858 2.361e-09 1.831e-06
7 POSITIVE REGULATION OF RESPONSE TO STIMULUS 83 1929 2.428e-08 1.412e-05
8 REGULATION OF MULTICELLULAR ORGANISMAL DEVELOPMENT 75 1672 2.398e-08 1.412e-05
9 MYELOID CELL DIFFERENTIATION 19 189 9.651e-08 4.94e-05
10 RESPONSE TO CYTOKINE 41 714 1.062e-07 4.94e-05
11 POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS 64 1395 1.34e-07 5.67e-05
12 POSITIVE REGULATION OF GENE EXPRESSION 74 1733 2.182e-07 8.314e-05
13 DEFENSE RESPONSE 58 1231 2.323e-07 8.314e-05
14 REGULATION OF CELL DIFFERENTIATION 66 1492 3.143e-07 0.0001045
15 POSITIVE REGULATION OF MOLECULAR FUNCTION 75 1791 3.827e-07 0.0001187
16 INNATE IMMUNE RESPONSE 36 619 4.848e-07 0.000141
17 INTERACTION WITH HOST 15 134 5.454e-07 0.0001493
18 INTERFERON GAMMA MEDIATED SIGNALING PATHWAY 11 70 5.997e-07 0.000155
19 POSITIVE REGULATION OF CELL COMMUNICATION 66 1532 8.029e-07 0.0001782
20 REGULATION OF RESPONSE TO STRESS 64 1468 8.045e-07 0.0001782
21 POSITIVE REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 49 1004 8.033e-07 0.0001782
22 INTRACELLULAR SIGNAL TRANSDUCTION 67 1572 9.564e-07 0.0001978
23 REGULATION OF CELL PROJECTION ORGANIZATION 33 558 1.02e-06 0.0001978
24 REGULATION OF TRANSPORT 74 1804 1.015e-06 0.0001978
25 POSITIVE REGULATION OF HYDROLASE ACTIVITY 45 905 1.419e-06 0.0002539
26 LOCOMOTION 52 1114 1.369e-06 0.0002539
27 NEGATIVE REGULATION OF CELL COMMUNICATION 54 1192 2.079e-06 0.0003584
28 CELLULAR RESPONSE TO CYTOKINE STIMULUS 34 606 2.259e-06 0.0003754
29 IMMUNE SYSTEM DEVELOPMENT 33 582 2.548e-06 0.0004088
30 NEGATIVE REGULATION OF RESPONSE TO STIMULUS 59 1360 2.664e-06 0.0004132
31 NEUROGENESIS 60 1402 3.34e-06 0.0004936
32 MOVEMENT OF CELL OR SUBCELLULAR COMPONENT 56 1275 3.395e-06 0.0004936
33 IMMUNE EFFECTOR PROCESS 29 486 3.918e-06 0.0005524
34 REGULATION OF CELLULAR COMPONENT BIOGENESIS 39 767 4.378e-06 0.0005858
35 NEGATIVE REGULATION OF IMMUNE EFFECTOR PROCESS 12 102 4.406e-06 0.0005858
36 RESPONSE TO BIOTIC STIMULUS 43 886 4.549e-06 0.000588
37 REGULATION OF HEMOPOIESIS 22 314 4.829e-06 0.0005913
38 RESPONSE TO LIPID 43 888 4.813e-06 0.0005913
39 BLOOD VESSEL MORPHOGENESIS 24 364 5.119e-06 0.0006107
40 PLASMA MEMBRANE ORGANIZATION 17 203 5.714e-06 0.0006647
41 POSITIVE REGULATION OF HEMOPOIESIS 15 163 6.472e-06 0.0007264
42 ERYTHROCYTE HOMEOSTASIS 10 73 7.025e-06 0.0007264
43 REGULATION OF NEURON DIFFERENTIATION 31 554 6.72e-06 0.0007264
44 POSITIVE REGULATION OF CYTOKINE PRODUCTION 24 370 6.751e-06 0.0007264
45 RESPONSE TO INTERFERON GAMMA 14 144 6.955e-06 0.0007264
46 NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS 24 372 7.392e-06 0.0007477
47 REGULATION OF IMMUNE EFFECTOR PROCESS 26 424 7.683e-06 0.0007606
48 RESPONSE TO WOUNDING 31 563 9.257e-06 0.0008973
49 REGULATION OF CELL ACTIVATION 28 484 1.024e-05 0.0009161
50 CELLULAR RESPONSE TO LIPID 27 457 1.011e-05 0.0009161
51 RESPONSE TO EXTERNAL STIMULUS 71 1821 1.022e-05 0.0009161
52 PROTEIN PHOSPHORYLATION 44 944 9.715e-06 0.0009161
53 REGULATION OF HYDROLASE ACTIVITY 56 1327 1.102e-05 0.0009672
54 REGULATION OF NEURON PROJECTION DEVELOPMENT 25 408 1.163e-05 0.001002
55 REGULATION OF LYMPHOCYTE MEDIATED IMMUNITY 12 114 1.401e-05 0.001164
56 ENDOMEMBRANE SYSTEM ORGANIZATION 27 465 1.38e-05 0.001164
57 VASCULATURE DEVELOPMENT 27 469 1.606e-05 0.001311
58 WOUND HEALING 27 470 1.668e-05 0.001338
59 REGULATION OF LEUKOCYTE MEDIATED IMMUNITY 14 156 1.744e-05 0.001354
60 POSITIVE REGULATION OF TRANSPORT 43 936 1.745e-05 0.001354
61 RESPONSE TO ENDOGENOUS STIMULUS 59 1450 1.857e-05 0.001416
62 CARDIOVASCULAR SYSTEM DEVELOPMENT 38 788 1.918e-05 0.001417
63 CIRCULATORY SYSTEM DEVELOPMENT 38 788 1.918e-05 0.001417
64 REGULATION OF CYTOKINE PRODUCTION 30 563 2.402e-05 0.001668
65 CYTOKINE MEDIATED SIGNALING PATHWAY 26 452 2.336e-05 0.001668
66 POSITIVE REGULATION OF IMMUNE RESPONSE 30 563 2.402e-05 0.001668
67 REGULATION OF PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE 11 101 2.308e-05 0.001668
68 POSITIVE REGULATION OF BIOSYNTHETIC PROCESS 69 1805 2.629e-05 0.001747
69 CELLULAR RESPONSE TO OXYGEN CONTAINING COMPOUND 38 799 2.598e-05 0.001747
70 NEGATIVE REGULATION OF IMMUNE RESPONSE 12 121 2.565e-05 0.001747
71 CELLULAR RESPONSE TO INTERFERON GAMMA 12 122 2.786e-05 0.001826
72 CELLULAR RESPONSE TO BIOTIC STIMULUS 14 163 2.857e-05 0.001846
73 REGULATION OF CELL DEVELOPMENT 39 836 3.111e-05 0.001983
74 MYELOID CELL HOMEOSTASIS 10 88 3.742e-05 0.002322
75 T CELL MEDIATED IMMUNITY 6 28 3.73e-05 0.002322
76 POSITIVE REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 40 876 3.962e-05 0.002426
77 REGULATION OF CELL MORPHOGENESIS INVOLVED IN DIFFERENTIATION 21 337 4.542e-05 0.002648
78 REGULATION OF DEFENSE RESPONSE 36 759 4.496e-05 0.002648
79 POSITIVE REGULATION OF CELL ACTIVATION 20 311 4.429e-05 0.002648
80 REGULATION OF CELL PROLIFERATION 59 1496 4.553e-05 0.002648
81 REGULATION OF CYTOKINE PRODUCTION INVOLVED IN IMMUNE RESPONSE 8 57 4.891e-05 0.00281
82 REGULATION OF GTPASE ACTIVITY 33 673 4.954e-05 0.002811
83 VESICLE MEDIATED TRANSPORT 51 1239 5.345e-05 0.002996
84 REGULATION OF TRANSCRIPTION FROM RNA POLYMERASE II PROMOTER 67 1784 6.009e-05 0.003329
85 HOMEOSTASIS OF NUMBER OF CELLS 14 175 6.247e-05 0.00342
86 CELL MOTILITY 38 835 6.656e-05 0.00356
87 LOCALIZATION OF CELL 38 835 6.656e-05 0.00356
88 REGULATION OF INTRACELLULAR SIGNAL TRANSDUCTION 63 1656 7.079e-05 0.003738
89 RESPONSE TO VIRUS 17 247 7.15e-05 0.003738
90 POSITIVE REGULATION OF IMMUNE EFFECTOR PROCESS 13 156 7.487e-05 0.003829
91 IMMUNE RESPONSE REGULATING CELL SURFACE RECEPTOR SIGNALING PATHWAY 20 323 7.488e-05 0.003829
92 REGULATION OF RECEPTOR RECYCLING 5 20 7.723e-05 0.003906
93 DENDRITE DEVELOPMENT 9 79 8.947e-05 0.004476
94 CELLULAR RESPONSE TO ENDOGENOUS STIMULUS 43 1008 9.671e-05 0.004787
95 VESICLE ORGANIZATION 18 280 0.000106 0.004876
96 HOMEOSTATIC PROCESS 53 1337 0.0001004 0.004876
97 REGULATION OF INNATE IMMUNE RESPONSE 21 357 0.0001032 0.004876
98 REGULATION OF SECRETION 33 699 0.0001021 0.004876
99 RESPONSE TO ORGANIC CYCLIC COMPOUND 40 917 0.0001067 0.004876
100 TUBE DEVELOPMENT 28 552 0.0001044 0.004876
101 POSITIVE REGULATION OF DEVELOPMENTAL PROCESS 47 1142 0.0001069 0.004876
102 REGULATION OF CELL MORPHOGENESIS 28 552 0.0001044 0.004876
103 REGULATION OF SYNAPSE STRUCTURE OR ACTIVITY 16 232 0.0001132 0.005099
104 REGULATION OF CELLULAR LOCALIZATION 51 1277 0.000114 0.005099
105 RESPONSE TO OXYGEN CONTAINING COMPOUND 54 1381 0.0001222 0.005416
106 REGULATION OF RESPONSE TO EXTERNAL STIMULUS 40 926 0.000131 0.005752
107 ADAPTIVE IMMUNE RESPONSE 18 288 0.0001509 0.006564
108 RESPONSE TO INCREASED OXYGEN LEVELS 5 23 0.0001582 0.006746
109 RESPONSE TO HYPEROXIA 5 23 0.0001582 0.006746
110 PHOSPHORYLATION 49 1228 0.0001595 0.006746
111 LYMPHOCYTE ACTIVATION 20 342 0.0001621 0.006797
112 POSITIVE REGULATION OF SECRETION 21 370 0.0001693 0.007035
113 REGULATION OF NERVOUS SYSTEM DEVELOPMENT 34 750 0.0001734 0.00714
114 MOVEMENT IN ENVIRONMENT OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 9 87 0.0001893 0.007162
115 ENTRY INTO CELL OF OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 9 87 0.0001893 0.007162
116 LEUKOCYTE DIFFERENTIATION 18 292 0.0001791 0.007162
117 VIRAL ENTRY INTO HOST CELL 9 87 0.0001893 0.007162
118 ENTRY INTO OTHER ORGANISM INVOLVED IN SYMBIOTIC INTERACTION 9 87 0.0001893 0.007162
119 RESPONSE TO ESTROGEN 15 218 0.0001885 0.007162
120 MOVEMENT IN HOST ENVIRONMENT 9 87 0.0001893 0.007162
121 ENTRY INTO HOST 9 87 0.0001893 0.007162
122 ANGIOGENESIS 18 293 0.0001868 0.007162
123 ENTRY INTO HOST CELL 9 87 0.0001893 0.007162
124 RESPONSE TO MOLECULE OF BACTERIAL ORIGIN 19 321 0.0002015 0.00756
125 REGULATION OF VESICLE MEDIATED TRANSPORT 24 462 0.0002271 0.008385
126 POSITIVE REGULATION OF CATALYTIC ACTIVITY 57 1518 0.0002261 0.008385
127 MODULATION OF SYNAPTIC TRANSMISSION 18 301 0.0002598 0.009517
128 POSITIVE REGULATION OF PEPTIDASE ACTIVITY 12 154 0.0002635 0.009578
129 RESPONSE TO ABIOTIC STIMULUS 42 1024 0.0002697 0.009729
130 RESPONSE TO STEROID HORMONE 25 497 0.0002755 0.00986
NumGOOverlapSizeP ValueAdj. P Value
1 RIBONUCLEOTIDE BINDING 71 1860 2.069e-05 0.00961
2 RECEPTOR BINDING 60 1476 1.611e-05 0.00961
NumGOOverlapSizeP ValueAdj. P Value
1 CELL JUNCTION 67 1151 3.326e-12 1.943e-09
2 ANCHORING JUNCTION 31 489 5.042e-07 9.815e-05
3 GOLGI APPARATUS 64 1445 4.662e-07 9.815e-05
4 ACTIN CYTOSKELETON 28 444 2.005e-06 0.0002928
5 GOLGI APPARATUS PART 42 893 1.26e-05 0.001472
6 INTRINSIC COMPONENT OF PLASMA MEMBRANE 65 1649 1.818e-05 0.00177
7 GOLGI MEMBRANE 35 703 2.137e-05 0.001783
8 CELL SUBSTRATE JUNCTION 23 398 6.401e-05 0.004154
9 DENDRITE 25 451 6.099e-05 0.004154
10 PERINUCLEAR REGION OF CYTOPLASM 31 642 0.0001106 0.006456
11 INTRACELLULAR VESICLE 50 1259 0.0001527 0.008108
12 MEMBRANE REGION 46 1134 0.0001764 0.008587
13 ACTIN FILAMENT 8 70 0.0002147 0.008683
14 CELL LEADING EDGE 20 350 0.0002201 0.008683
15 SYNAPSE PART 29 610 0.0002379 0.008683
16 ENDOSOME 35 793 0.0002315 0.008683

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 MAPK_signaling_pathway_hsa04010 17 295 0.000582 0.01622
2 Endocytosis_hsa04144 15 244 0.0006239 0.01622
3 Adherens_junction_hsa04520 7 72 0.001406 0.02283
4 Sphingolipid_signaling_pathway_hsa04071 9 118 0.001756 0.02283
5 Apoptosis_hsa04210 9 138 0.005025 0.04436
6 Necroptosis_hsa04217 10 164 0.005119 0.04436
7 Hippo_signaling_pathway_hsa04390 9 154 0.01006 0.06448
8 Cytokine_cytokine_receptor_interaction_hsa04060 13 270 0.01092 0.06448
9 FoxO_signaling_pathway_hsa04068 8 132 0.0121 0.06448
10 TNF_signaling_pathway_hsa04668 7 108 0.0131 0.06448
11 Jak_STAT_signaling_pathway_hsa04630 9 162 0.01368 0.06448
12 Apelin_signaling_pathway_hsa04371 8 137 0.01488 0.06448
13 Cell_adhesion_molecules_.CAMs._hsa04514 8 145 0.02024 0.07534
14 ABC_transporters_hsa02010 4 45 0.02028 0.07534
15 Calcium_signaling_pathway_hsa04020 9 182 0.02684 0.09306
16 Hippo_signaling_pathway_multiple_species_hsa04392 3 29 0.02916 0.09478
17 Cellular_senescence_hsa04218 8 160 0.03376 0.1033
18 Phagosome_hsa04145 7 152 0.06491 0.1875
19 NF_kappa_B_signaling_pathway_hsa04064 5 95 0.07068 0.1934
20 HIF_1_signaling_pathway_hsa04066 5 100 0.08384 0.2106
21 cGMP_PKG_signaling_pathway_hsa04022 7 163 0.08667 0.2106
22 cAMP_signaling_pathway_hsa04024 8 198 0.09186 0.2106
23 Ras_signaling_pathway_hsa04014 9 232 0.09316 0.2106
24 Wnt_signaling_pathway_hsa04310 6 146 0.1256 0.2722
25 Gap_junction_hsa04540 4 88 0.1488 0.3023
26 VEGF_signaling_pathway_hsa04370 3 59 0.1577 0.3023
27 Cell_cycle_hsa04110 5 124 0.1628 0.3023
28 Oocyte_meiosis_hsa04114 5 124 0.1628 0.3023
29 Focal_adhesion_hsa04510 7 199 0.1824 0.3271
30 Mitophagy_animal_hsa04137 3 65 0.1923 0.3329
31 Phosphatidylinositol_signaling_system_hsa04070 4 99 0.199 0.3329
32 Tight_junction_hsa04530 6 170 0.2049 0.3329
33 Phospholipase_D_signaling_pathway_hsa04072 5 146 0.253 0.3987
34 PI3K_Akt_signaling_pathway_hsa04151 10 352 0.3043 0.4452
35 Notch_signaling_pathway_hsa04330 2 48 0.3074 0.4452
36 TGF_beta_signaling_pathway_hsa04350 3 84 0.3104 0.4452
37 ErbB_signaling_pathway_hsa04012 3 85 0.3168 0.4452
38 Rap1_signaling_pathway_hsa04015 6 206 0.3465 0.4742
39 mTOR_signaling_pathway_hsa04150 4 151 0.4674 0.6129
40 p53_signaling_pathway_hsa04115 2 68 0.4714 0.6129
41 ECM_receptor_interaction_hsa04512 2 82 0.5716 0.6993
42 Peroxisome_hsa04146 2 83 0.5782 0.6993
43 Neuroactive_ligand_receptor_interaction_hsa04080 6 278 0.6297 0.7286
44 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 3 139 0.6306 0.7286
45 Regulation_of_actin_cytoskeleton_hsa04810 4 208 0.7159 0.792
46 AMPK_signaling_pathway_hsa04152 2 121 0.7757 0.8403
47 Autophagy_animal_hsa04140 2 128 0.8017 0.8508

Quest ID: effcf74744ee1e38e48f97a69c3082ea