Visible node/edge number:
Node colors:
Node labels:

show label of nodes with degree >=

Node sizes:
Edge colors:
Edge widths factor:
Layout:

gravity >=

edgeLength =

GRN in network:

Notice: IE browser need to manually refresh (F5) this page after resetting the network.

This regulatory network was inferred from the input dataset. The miRNAs and mRNAs are presented as round and rectangle nodes respectively. The numerical value popped up upon mouse over the gene node is the log2 transformed fold-change of the gene expression between the two groups. All of the nodes are clickable, and the detailed information of the miRNAs/mRNAs and related cancer pathway will be displayed in another window. The edges between nodes are supported by both interactions (predicted or experimentally verified) and correlations learnt from cancer dataset. The numerical value popped up upon mouse over the edge is the correlation beat value (effect size) between the two nodes. The experimental evidences of the edges reported in previous cancer studies are highlighted by red/orange color. All of these information can be accessed by the "mouse-over" action. This network shows a full map of the miRNA-mRNA regulation of the input gene list(s), and the hub miRNAs (with the high network degree/betweenness centrality) would be the potential cancer drivers or tumor suppressors. The full result table can be accessed in the "Regulations" tab.

"miRNACancerMAP" is also a network visualization tool for users to draw their regulatory network by personal customization. Users can set the complexity of the network by limiting the number of nodes or edges. And the color of the nodes can be defined by different categories of the mRNAs and miRNAs, such as Gene-Ontology, pathway, and expression status. Users can also select to use network degree or network betweenness centrality to define the node size. And edges can be black or colored by the correlation. Purple edge means negative correlation (mostly found between miRNA and mRNA), and blue edge means positive correlation (found in PPI or miRNA-miRNA sponge effect). We can also add the protein-protein interactions (PPI) into the network. This result will show the cluster of genes regulated by some specific miRNAs. Additionally, miRNA-miRNA edges can be added by the "miRNA sponge" button, presenting some clusters of miRNAs that have the interactions via sponge effect.

miRNA-gene regulations

(Download full result)

Num microRNA           Gene miRNA log2FC miRNA pvalue Gene log2FC Gene pvalue Interaction Correlation beta Correlation P-value PMID Reported in cancer studies
1 hsa-miR-26a-2-3p ABHD2 0.26 0.30565 -0.74 0.00059 mirMAP -0.21 2.0E-5 NA
2 hsa-miR-26a-2-3p ADAM28 0.26 0.30565 2.16 0 mirMAP -0.22 0.00321 NA
3 hsa-miR-26a-2-3p AGPS 0.26 0.30565 0 0.99631 mirMAP -0.13 0 NA
4 hsa-miR-26a-2-3p AP2B1 0.26 0.30565 -0.07 0.54488 mirMAP -0.11 8.0E-5 NA
5 hsa-miR-26a-2-3p ARL5B 0.26 0.30565 0.2 0.27406 mirMAP -0.2 0 NA
6 hsa-miR-26a-2-3p ASXL2 0.26 0.30565 -0.3 0.12837 mirMAP -0.24 0 NA
7 hsa-miR-26a-2-3p ATE1 0.26 0.30565 -0.47 0.01177 mirMAP -0.3 0 NA
8 hsa-miR-26a-2-3p ATL3 0.26 0.30565 0.11 0.46975 mirMAP -0.16 0 NA
9 hsa-miR-26a-2-3p BARD1 0.26 0.30565 0.84 0.00035 mirMAP -0.16 0.00208 NA
10 hsa-miR-26a-2-3p BBX 0.26 0.30565 -0.3 0.02503 MirTarget; mirMAP -0.1 0.00036 NA
11 hsa-miR-26a-2-3p BMPR2 0.26 0.30565 -1.25 0 mirMAP -0.1 0.00041 NA
12 hsa-miR-26a-2-3p CADM2 0.26 0.30565 -0.95 0.08706 MirTarget -0.28 0.02523 NA
13 hsa-miR-26a-2-3p CASC4 0.26 0.30565 -0.1 0.37799 mirMAP -0.18 0 NA
14 hsa-miR-26a-2-3p CLOCK 0.26 0.30565 0.04 0.82828 mirMAP -0.21 0 NA
15 hsa-miR-26a-2-3p CSRNP3 0.26 0.30565 -0.53 0.17748 mirMAP -0.34 0.00012 NA
16 hsa-miR-26a-2-3p CTAGE1 0.26 0.30565 0.07 0.78056 mirMAP -0.26 1.0E-5 NA
17 hsa-miR-26a-2-3p CTNND1 0.26 0.30565 -0.12 0.34444 mirMAP -0.1 0.00018 NA
18 hsa-miR-26a-2-3p CTNND2 0.26 0.30565 -3.29 3.0E-5 MirTarget -0.49 0.00607 NA
19 hsa-miR-26a-2-3p DCUN1D1 0.26 0.30565 0.14 0.30132 mirMAP -0.14 1.0E-5 NA
20 hsa-miR-26a-2-3p DNAJB14 0.26 0.30565 -0.4 0.00192 mirMAP -0.15 0 NA
21 hsa-miR-26a-2-3p DOK6 0.26 0.30565 -1.82 0 mirMAP -0.17 0.02074 NA
22 hsa-miR-26a-2-3p EDEM3 0.26 0.30565 0.53 7.0E-5 mirMAP -0.18 0 NA
23 hsa-miR-26a-2-3p EIF2AK2 0.26 0.30565 0.62 9.0E-5 mirMAP -0.11 0.00199 NA
24 hsa-miR-26a-2-3p EIF5A2 0.26 0.30565 -0.01 0.97137 mirMAP -0.17 0.0003 NA
25 hsa-miR-26a-2-3p ENTPD7 0.26 0.30565 0.96 0 MirTarget -0.15 0.00014 NA
26 hsa-miR-26a-2-3p FAM102B 0.26 0.30565 -0.59 0.00326 mirMAP -0.13 0.00526 NA
27 hsa-miR-26a-2-3p FAM199X 0.26 0.30565 0.79 0 mirMAP -0.19 0 NA
28 hsa-miR-26a-2-3p FBXO22 0.26 0.30565 0.39 0.00092 mirMAP -0.13 0 NA
29 hsa-miR-26a-2-3p FLVCR1 0.26 0.30565 1.37 0 mirMAP -0.15 0.00117 NA
30 hsa-miR-26a-2-3p FRMD3 0.26 0.30565 -3.32 0 mirMAP -0.33 2.0E-5 NA
31 hsa-miR-26a-2-3p FSTL5 0.26 0.30565 0.85 0.19421 MirTarget -0.37 0.01061 NA
32 hsa-miR-26a-2-3p FTO 0.26 0.30565 -0.77 0 mirMAP -0.12 4.0E-5 NA
33 hsa-miR-26a-2-3p GLUD2 0.26 0.30565 -0.53 0.00063 MirTarget -0.2 0 NA
34 hsa-miR-26a-2-3p GULP1 0.26 0.30565 0.1 0.75153 mirMAP -0.29 1.0E-5 NA
35 hsa-miR-26a-2-3p HS2ST1 0.26 0.30565 0.16 0.27392 mirMAP -0.12 0.0001 NA
36 hsa-miR-26a-2-3p IDE 0.26 0.30565 0.48 0.00206 MirTarget -0.22 0 NA
37 hsa-miR-26a-2-3p IL6ST 0.26 0.30565 -1.4 0 MirTarget -0.29 1.0E-5 NA
38 hsa-miR-26a-2-3p KCND2 0.26 0.30565 1.52 0.00037 MirTarget -0.23 0.01759 NA
39 hsa-miR-26a-2-3p KDM5A 0.26 0.30565 -0.03 0.8246 mirMAP -0.11 3.0E-5 NA
40 hsa-miR-26a-2-3p KIAA1958 0.26 0.30565 -0.15 0.4659 mirMAP -0.22 0 NA
41 hsa-miR-26a-2-3p KRR1 0.26 0.30565 0.24 0.04629 mirMAP -0.1 0.00019 NA
42 hsa-miR-26a-2-3p LCORL 0.26 0.30565 -0.45 0.00401 mirMAP -0.16 0 NA
43 hsa-miR-26a-2-3p LMBRD2 0.26 0.30565 0.31 0.13546 mirMAP -0.21 1.0E-5 NA
44 hsa-miR-26a-2-3p LMO4 0.26 0.30565 -0.3 0.14286 mirMAP -0.11 0.0216 NA
45 hsa-miR-26a-2-3p MAN1A2 0.26 0.30565 0.24 0.13502 MirTarget -0.25 0 NA
46 hsa-miR-26a-2-3p MAP3K2 0.26 0.30565 0.17 0.19884 mirMAP -0.17 0 NA
47 hsa-miR-26a-2-3p MARCH8 0.26 0.30565 -0.63 0.00037 mirMAP -0.15 0.00016 NA
48 hsa-miR-26a-2-3p MGAT5 0.26 0.30565 -0.25 0.35399 mirMAP -0.23 0.00013 NA
49 hsa-miR-26a-2-3p MMP16 0.26 0.30565 0.34 0.32834 mirMAP -0.17 0.02956 NA
50 hsa-miR-26a-2-3p MRPL19 0.26 0.30565 0.53 0 mirMAP -0.11 0 NA
51 hsa-miR-26a-2-3p NEK7 0.26 0.30565 -0.98 0 mirMAP -0.13 2.0E-5 NA
52 hsa-miR-26a-2-3p NEO1 0.26 0.30565 -0.86 0.00045 mirMAP -0.19 0.00065 NA
53 hsa-miR-26a-2-3p NFIC 0.26 0.30565 -0.78 2.0E-5 mirMAP -0.1 0.0139 NA
54 hsa-miR-26a-2-3p NLN 0.26 0.30565 1.36 0 mirMAP -0.13 0.00187 NA
55 hsa-miR-26a-2-3p OSBPL10 0.26 0.30565 0.11 0.50853 mirMAP -0.17 0 NA
56 hsa-miR-26a-2-3p PABPC5 0.26 0.30565 -1.37 0 MirTarget -0.2 0.00138 NA
57 hsa-miR-26a-2-3p PCGF5 0.26 0.30565 -0.57 6.0E-5 mirMAP -0.12 0.00027 NA
58 hsa-miR-26a-2-3p PHF14 0.26 0.30565 0.47 0.00015 MirTarget -0.12 1.0E-5 NA
59 hsa-miR-26a-2-3p PIK3C2A 0.26 0.30565 -0.45 6.0E-5 MirTarget -0.14 0 NA
60 hsa-miR-26a-2-3p PIK3C3 0.26 0.30565 -0.28 0.01528 mirMAP -0.12 1.0E-5 NA
61 hsa-miR-26a-2-3p PITPNC1 0.26 0.30565 0.36 0.14945 mirMAP -0.14 0.01498 NA
62 hsa-miR-26a-2-3p PLA2R1 0.26 0.30565 -0.61 0.0133 mirMAP -0.18 0.00102 NA
63 hsa-miR-26a-2-3p PLEKHB2 0.26 0.30565 -0.44 5.0E-5 mirMAP -0.11 1.0E-5 NA
64 hsa-miR-26a-2-3p POU2F1 0.26 0.30565 0.47 0.02964 mirMAP -0.19 0.00012 NA
65 hsa-miR-26a-2-3p PRKG1 0.26 0.30565 -2.25 0 mirMAP -0.26 0.00047 NA
66 hsa-miR-26a-2-3p PTPRG 0.26 0.30565 -1.35 0 mirMAP -0.18 0.00166 NA
67 hsa-miR-26a-2-3p RAB3B 0.26 0.30565 2.33 8.0E-5 mirMAP -0.55 3.0E-5 NA
68 hsa-miR-26a-2-3p RHOU 0.26 0.30565 -0.21 0.38128 MirTarget -0.17 0.00144 NA
69 hsa-miR-26a-2-3p RNF186 0.26 0.30565 2.91 0 MirTarget -0.31 0.02396 NA
70 hsa-miR-26a-2-3p RPL7L1 0.26 0.30565 0.34 0.0025 mirMAP -0.12 0 NA
71 hsa-miR-26a-2-3p RPRD1A 0.26 0.30565 -0.01 0.94063 mirMAP -0.14 5.0E-5 NA
72 hsa-miR-26a-2-3p SAMD8 0.26 0.30565 -0.2 0.17739 MirTarget; mirMAP -0.18 0 NA
73 hsa-miR-26a-2-3p SAR1B 0.26 0.30565 0.66 0 MirTarget -0.1 0.0009 NA
74 hsa-miR-26a-2-3p SCAMP1 0.26 0.30565 -0.01 0.91709 MirTarget -0.17 0 NA
75 hsa-miR-26a-2-3p SEC24D 0.26 0.30565 0.66 0 mirMAP -0.12 9.0E-5 NA
76 hsa-miR-26a-2-3p SEL1L3 0.26 0.30565 0.58 0.0003 MirTarget -0.12 0.00052 NA
77 hsa-miR-26a-2-3p SLC22A23 0.26 0.30565 -0.23 0.39635 mirMAP -0.13 0.03401 NA
78 hsa-miR-26a-2-3p SLC30A6 0.26 0.30565 0.36 0.00925 mirMAP -0.2 0 NA
79 hsa-miR-26a-2-3p SNAPC3 0.26 0.30565 0.15 0.24745 mirMAP -0.11 0.00017 NA
80 hsa-miR-26a-2-3p SOS1 0.26 0.30565 0.08 0.43291 mirMAP -0.12 0 NA
81 hsa-miR-26a-2-3p SPATA13 0.26 0.30565 -0.79 0.00029 mirMAP -0.1 0.03283 NA
82 hsa-miR-26a-2-3p STXBP5L 0.26 0.30565 0.69 0.23155 mirMAP -0.32 0.01308 NA
83 hsa-miR-26a-2-3p TAOK1 0.26 0.30565 -0.16 0.47617 mirMAP -0.29 0 NA
84 hsa-miR-26a-2-3p TBC1D8B 0.26 0.30565 0.17 0.31767 mirMAP -0.15 5.0E-5 NA
85 hsa-miR-26a-2-3p TCP11L2 0.26 0.30565 -1.21 0 mirMAP -0.17 7.0E-5 NA
86 hsa-miR-26a-2-3p TM9SF3 0.26 0.30565 0.34 0.00384 MirTarget; mirMAP -0.16 0 NA
87 hsa-miR-26a-2-3p TMED7-TICAM2 0.26 0.30565 1.58 0.00018 mirMAP -0.24 0.01067 NA
88 hsa-miR-26a-2-3p TMEM47 0.26 0.30565 -1.95 0 mirMAP -0.15 0.00692 NA
89 hsa-miR-26a-2-3p TNPO1 0.26 0.30565 0.25 0.03493 mirMAP -0.14 0 NA
90 hsa-miR-26a-2-3p TSHZ2 0.26 0.30565 -0.21 0.51808 mirMAP -0.26 0.00029 NA
91 hsa-miR-26a-2-3p TTBK2 0.26 0.30565 -0.75 6.0E-5 mirMAP -0.13 0.00283 NA
92 hsa-miR-26a-2-3p UBR1 0.26 0.30565 -0.16 0.22626 mirMAP -0.16 0 NA
93 hsa-miR-26a-2-3p USP37 0.26 0.30565 0.57 0 mirMAP -0.13 0 NA
94 hsa-miR-26a-2-3p VPS37A 0.26 0.30565 0.06 0.71911 mirMAP -0.22 0 NA
95 hsa-miR-26a-2-3p ZBTB10 0.26 0.30565 0.26 0.23691 mirMAP -0.12 0.01177 NA
96 hsa-miR-26a-2-3p ZBTB38 0.26 0.30565 -0.48 0.00029 mirMAP -0.12 5.0E-5 NA
97 hsa-miR-26a-2-3p ZNF420 0.26 0.30565 -0 0.99779 MirTarget -0.16 0 NA
98 hsa-miR-26a-2-3p ZNF585A 0.26 0.30565 0.05 0.72133 mirMAP -0.11 0.00083 NA

Over-represented Gene Ontology Biological Process

NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value
NumGOOverlapSizeP ValueAdj. P Value

Over-represented Pathway

NumPathwayPathviewOverlapSizeP ValueAdj. P Value
1 Gap_junction_hsa04540 3 88 0.009268 0.4819
2 Signaling_pathways_regulating_pluripotency_of_stem_cells_hsa04550 3 139 0.03096 0.8051
3 Phosphatidylinositol_signaling_system_hsa04070 2 99 0.08495 1
4 Phagosome_hsa04145 2 152 0.1709 1
5 MAPK_signaling_pathway_hsa04010 3 295 0.1762 1
6 Jak_STAT_signaling_pathway_hsa04630 2 162 0.1885 1
7 Necroptosis_hsa04217 2 164 0.192 1
8 Regulation_of_actin_cytoskeleton_hsa04810 2 208 0.2713 1
9 Endocytosis_hsa04144 2 244 0.3364 1
10 Cytokine_cytokine_receptor_interaction_hsa04060 2 270 0.3823 1

Quest ID: fde4be3325e384eb4cc59ec5b47f397a