CR2Cancer

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00022 Actin

Function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	10966108

> Gene Ontology [ TOP ]
Biological Process	GO:0001894 tissue homeostasis GO:0001895 retina homeostasis GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006338 chromatin remodeling GO:0006909 phagocytosis GO:0007596 blood coagulation GO:0007599 hemostasis GO:0021762 substantia nigra development GO:0030168 platelet activation GO:0030901 midbrain development GO:0034109 homotypic cell-cell adhesion GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0040029 regulation of gene expression, epigenetic GO:0043044 ATP-dependent chromatin remodeling GO:0045815 positive regulation of gene expression, epigenetic GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048013 ephrin receptor signaling pathway GO:0048857 neural nucleus development GO:0048871 multicellular organismal homeostasis GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0060249 anatomical structure homeostasis GO:0070527 platelet aggregation
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0005200 structural constituent of cytoskeleton GO:0008134 transcription factor binding GO:0019894 kinesin binding GO:0030957 Tat protein binding GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0035326 enhancer binding GO:0043566 structure-specific DNA binding GO:0050998 nitric-oxide synthase binding
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0005938 cell cortex GO:0030055 cell-substrate junction GO:0030863 cortical cytoskeleton GO:0031248 protein acetyltransferase complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0035267 NuA4 histone acetyltransferase complex GO:0035770 ribonucleoprotein granule GO:0036464 cytoplasmic ribonucleoprotein granule GO:0043189 H4/H2A histone acetyltransferase complex GO:0043209 myelin sheath GO:0044448 cell cortex part GO:0044454 nuclear chromosome part GO:0070688 MLL5-L complex GO:0072562 blood microparticle GO:0097433 dense body GO:0099568 cytoplasmic region GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04015 Rap1 signaling pathway hsa04145 Phagosome hsa04210 Apoptosis hsa04390 Hippo signaling pathway hsa04510 Focal adhesion hsa04520 Adherens junction hsa04530 Tight junction hsa04611 Platelet activation hsa04670 Leukocyte transendothelial migration hsa04810 Regulation of actin cytoskeleton hsa04919 Thyroid hormone signaling pathway hsa04921 Oxytocin signaling pathway hsa04971 Gastric acid secretion
Reactome	R-HSA-422475: Axon guidance R-HSA-5250924: B-WICH complex positively regulates rRNA expression R-HSA-390466: Chaperonin-mediated protein folding R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-389958: Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-5696394: DNA Damage Recognition in GG-NER R-HSA-73894: DNA Repair R-HSA-5688426: Deubiquitination R-HSA-1266738: Developmental Biology R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928662: EPHB-mediated forward signaling R-HSA-212165: Epigenetic regulation of gene expression R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-390450: Folding of actin by CCT/TriC R-HSA-74160: Gene Expression R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-3214847: HATs acetylate histones R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-428359: Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA R-HSA-392499: Metabolism of proteins R-HSA-5696398: Nucleotide Excision Repair R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-597592: Post-translational protein modification R-HSA-389957: Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-391251: Protein folding R-HSA-195258: RHO GTPase Effectors R-HSA-5663220: RHO GTPases Activate Formins R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-5689603: UCH proteinases

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04015 Rap1 signaling pathway
hsa04145 Phagosome
hsa04210 Apoptosis
hsa04390 Hippo signaling pathway
hsa04510 Focal adhesion
hsa04520 Adherens junction
hsa04530 Tight junction
hsa04611 Platelet activation
hsa04670 Leukocyte transendothelial migration
hsa04810 Regulation of actin cytoskeleton
hsa04919 Thyroid hormone signaling pathway
hsa04921 Oxytocin signaling pathway
hsa04971 Gastric acid secretion

Reactome

R-HSA-422475: Axon guidance
R-HSA-5250924: B-WICH complex positively regulates rRNA expression
R-HSA-390466: Chaperonin-mediated protein folding
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-389958: Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
R-HSA-5696394: DNA Damage Recognition in GG-NER
R-HSA-73894: DNA Repair
R-HSA-5688426: Deubiquitination
R-HSA-1266738: Developmental Biology
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-3928662: EPHB-mediated forward signaling
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-390450: Folding of actin by CCT/TriC
R-HSA-74160: Gene Expression
R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-3214847: HATs acetylate histones
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-428359: Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
R-HSA-392499: Metabolism of proteins
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-597592: Post-translational protein modification
R-HSA-389957: Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-391251: Protein folding
R-HSA-195258: RHO GTPase Effectors
R-HSA-5663220: RHO GTPases Activate Formins
R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs
R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
R-HSA-5689603: UCH proteinases

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3778510	c.1043C>G	p.S348W	Substitution - Missense	Urinary_tract
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1313190	c.472G>A	p.G158R	Substitution - Missense	Urinary_tract
COSM384503	c.484A>G	p.T162A	Substitution - Missense	Lung
COSM3995648	c.1033A>C	p.I345L	Substitution - Missense	Upper_aerodigestive_tract
COSM5927452	c.409C>T	p.Q137*	Substitution - Nonsense	Skin
COSM5606302	c.826G>A	p.E276K	Substitution - Missense	Skin
COSM5713899	c.124-4C>G	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3995647	c.1034T>C	p.I345T	Substitution - Missense	Kidney
COSM5890270	c.899C>A	p.S300Y	Substitution - Missense	Skin
COSM3881873	c.591C>A	p.G197G	Substitution - coding silent	Stomach
COSM4971714	c.1125C>T	p.F375F	Substitution - coding silent	Central_nervous_system
COSM1755318	c.434C>T	p.S145F	Substitution - Missense	Urinary_tract
COSM5640340	c.139A>G	p.M47V	Substitution - Missense	Oesophagus
COSM1658924	c.277G>A	p.E93K	Substitution - Missense	Skin
COSM5797116	c.366C>T	p.I122I	Substitution - coding silent	Skin
COSM5619800	c.280C>G	p.L94V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5891967	c.141G>A	p.M47I	Substitution - Missense	Skin
COSM4153051	c.455T>C	p.V152A	Substitution - Missense	Kidney
COSM346909	c.382A>G	p.N128D	Substitution - Missense	Lung
COSM1755320	c.147G>A	p.Q49Q	Substitution - coding silent	Urinary_tract
COSM5002631	c.872A>C	p.K291T	Substitution - Missense	Pancreas
COSM5749236	c.217C>G	p.H73D	Substitution - Missense	Genital_tract
COSM3266921	c.79C>T	p.P27S	Substitution - Missense	Upper_aerodigestive_tract
COSM3266881	c.923G>A	p.G308D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5619799	c.293C>T	p.P98L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5038955	c.650G>T	p.C217F	Substitution - Missense	Liver
COSM1550013	c.63C>T	p.F21F	Substitution - coding silent	Skin
COSM3881872	c.658G>A	p.A220T	Substitution - Missense	Stomach
COSM1550016	c.1000G>A	p.E334K	Substitution - Missense	Skin
COSM1658924	c.277G>A	p.E93K	Substitution - Missense	Skin
COSM5619802	c.164G>A	p.G55D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM318488	c.35A>G	p.N12S	Substitution - Missense	Lung
COSM3394838	c.747C>T	p.T249T	Substitution - coding silent	Pancreas
COSM3833037	c.364-1G>T	p.?	Unknown	Breast
COSM5002310	c.63C>G	p.F21L	Substitution - Missense	Pancreas
COSM3698485	c.661C>T	p.L221L	Substitution - coding silent	Large_intestine
COSM1658924	c.277G>A	p.E93K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1622997	c.424C>T	p.L142L	Substitution - coding silent	Liver
COSM2150972	c.1038delG	p.A347fs*>29	Deletion - Frameshift	Central_nervous_system
COSM1451626	c.590G>A	p.G197D	Substitution - Missense	Large_intestine
COSM1161682	c.180C>G	p.S60R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3995648	c.1033A>C	p.I345L	Substitution - Missense	Kidney
COSM1658924	c.277G>A	p.E93K	Substitution - Missense	Salivary_gland
COSM1451627	c.302A>G	p.H101R	Substitution - Missense	Large_intestine
COSM5906792	c.481C>A	p.H161N	Substitution - Missense	Skin
COSM1622996	c.504delG	p.Y169fs*17	Deletion - Frameshift	Liver
COSM1741422	c.775G>A	p.E259K	Substitution - Missense	Urinary_tract
COSM5835429	c.677delA	p.E226fs*58	Deletion - Frameshift	Breast
COSM3266891	c.642G>A	p.E214E	Substitution - coding silent	Oesophagus
COSM268571	c.395T>C	p.M132T	Substitution - Missense	Large_intestine
COSM1755318	c.434C>T	p.S145F	Substitution - Missense	Urinary_tract
COSM1090914	c.416T>C	p.V139A	Substitution - Missense	Large_intestine
COSM3995649	c.515C>G	p.P172R	Substitution - Missense	Kidney
COSM301622	c.284G>A	p.R95H	Substitution - Missense	Salivary_gland
COSM4971715	c.453C>T	p.I151I	Substitution - coding silent	Central_nervous_system
COSM3995646	c.1042T>C	p.S348P	Substitution - Missense	Kidney
COSM1550016	c.1000G>A	p.E334K	Substitution - Missense	Upper_aerodigestive_tract
COSM5651117	c.188G>A	p.G63D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5948737	c.151G>T	p.D51Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3881875	c.185G>C	p.R62T	Substitution - Missense	Stomach
COSM5798934	c.241G>A	p.D81N	Substitution - Missense	Breast
COSM1313189	c.1043C>T	p.S348L	Substitution - Missense	Urinary_tract
COSM5713897	c.127G>C	p.V43L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5152578	c.229A>T	p.T77S	Substitution - Missense	Large_intestine
COSM3778510	c.1043C>G	p.S348W	Substitution - Missense	Cervix
COSM4504263	c.660C>T	p.A220A	Substitution - coding silent	Skin
COSM1451625	c.903C>T	p.G301G	Substitution - coding silent	Large_intestine
COSM5014667	c.1033A>T	p.I345F	Substitution - Missense	Kidney
COSM238669	c.778G>A	p.A260T	Substitution - Missense	Large_intestine
COSM3663287	c.57C>G	p.A19A	Substitution - coding silent	Liver
COSM453257	c.82C>A	p.R28R	Substitution - coding silent	Breast
COSM5714267	c.142G>A	p.G48S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4602332	c.166G>A	p.D56N	Substitution - Missense	Upper_aerodigestive_tract
COSM5714269	c.141G>C	p.M47I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5961828	c.360C>T	p.T120T	Substitution - coding silent	Adrenal_gland
COSM4520641	c.1068G>C	p.W356C	Substitution - Missense	Skin
COSM1755317	c.669C>A	p.F223L	Substitution - Missense	Urinary_tract
COSM3881869	c.962C>T	p.A321V	Substitution - Missense	Stomach
COSM5710636	c.59G>A	p.G20D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3639801	c.516C>T	p.P172P	Substitution - coding silent	Skin
COSM747412	c.1062G>C	p.Q354H	Substitution - Missense	Lung
COSM301622	c.284G>A	p.R95H	Substitution - Missense	Central_nervous_system
COSM5606302	c.826G>A	p.E276K	Substitution - Missense	Skin
COSM5042200	c.613G>A	p.E205K	Substitution - Missense	Liver
COSM1755319	c.373G>A	p.E125K	Substitution - Missense	Urinary_tract
COSM3685188	c.1040C>G	p.A347G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5984709	c.808G>C	p.E270Q	Substitution - Missense	Upper_aerodigestive_tract
COSM5714472	c.131T>C	p.M44T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3778511	c.24C>A	p.L8L	Substitution - coding silent	Urinary_tract
COSM3639803	c.298G>A	p.E100K	Substitution - Missense	Skin
COSM3923842	c.772C>T	p.P258S	Substitution - Missense	Skin
COSM1550014	c.670G>C	p.E224Q	Substitution - Missense	Breast
COSM1313189	c.1043C>T	p.S348L	Substitution - Missense	Urinary_tract
COSM5003107	c.1030T>G	p.S344A	Substitution - Missense	Pancreas
COSM1090913	c.628C>T	p.R210C	Substitution - Missense	Endometrium
COSM453256	c.761G>A	p.R254Q	Substitution - Missense	Breast
COSM5606302	c.826G>A	p.E276K	Substitution - Missense	Skin
COSM5606302	c.826G>A	p.E276K	Substitution - Missense	Skin
COSM1181713	c.859G>A	p.V287M	Substitution - Missense	Large_intestine
COSM5948739	c.124-6T>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5725892	c.81C>T	p.P27P	Substitution - coding silent	Skin
COSM3669743	c.124-1G>T	p.?	Unknown	Liver
COSM4659093	c.82delC	p.R28fs*16	Deletion - Frameshift	Large_intestine
COSM5953905	c.1014C>A	p.S338S	Substitution - coding silent	Upper_aerodigestive_tract
COSM4854770	c.714G>C	p.K238N	Substitution - Missense	Cervix
COSM4659092	c.440G>A	p.R147H	Substitution - Missense	Large_intestine
COSM5908713	c.1024G>A	p.G342S	Substitution - Missense	Skin
COSM1090914	c.416T>C	p.V139A	Substitution - Missense	Endometrium
COSM1755316	c.1031C>G	p.S344C	Substitution - Missense	Urinary_tract
COSM5818760	c.897G>T	p.L299L	Substitution - coding silent	Liver
COSM301622	c.284G>A	p.R95H	Substitution - Missense	Central_nervous_system
COSM1313190	c.472G>A	p.G158R	Substitution - Missense	Urinary_tract
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3995651	c.178A>G	p.S60G	Substitution - Missense	Kidney
COSM5790666	c.213C>G	p.I71M	Substitution - Missense	Breast
COSM1090912	c.720delC	p.Y240fs*1	Deletion - Frameshift	Endometrium
COSM1313189	c.1043C>T	p.S348L	Substitution - Missense	Urinary_tract
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3663287	c.57C>G	p.A19A	Substitution - coding silent	Liver
COSM360281	c.1017G>A	p.V339V	Substitution - coding silent	Lung
COSM1313190	c.472G>A	p.G158R	Substitution - Missense	Urinary_tract
COSM5152580	c.5A>C	p.D2A	Substitution - Missense	Large_intestine
COSM1622997	c.424C>T	p.L142L	Substitution - coding silent	Liver
COSM1755316	c.1031C>G	p.S344C	Substitution - Missense	Urinary_tract
COSM1658825	c.1055_1056insA	p.F352fs*12	Insertion - Frameshift	Salivary_gland
COSM5684241	c.502G>T	p.G168W	Substitution - Missense	Soft_tissue
COSM5606302	c.826G>A	p.E276K	Substitution - Missense	Skin
COSM5710636	c.59G>A	p.G20D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1330577	c.496T>C	p.Y166H	Substitution - Missense	Ovary
COSM3881874	c.586C>T	p.R196C	Substitution - Missense	Stomach
COSM3639804	c.99C>T	p.S33S	Substitution - coding silent	Skin
COSM5797116	c.366C>T	p.I122I	Substitution - coding silent	Breast
COSM5935226	c.794C>T	p.S265F	Substitution - Missense	Skin
COSM5619804	c.13A>G	p.I5V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1313191	c.277G>C	p.E93Q	Substitution - Missense	Urinary_tract
COSM5802087	c.1063_1064insCCAGCAGAT	p.M355>TSRL	Complex - insertion inframe	Breast
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1644360	c.1033A>G	p.I345V	Substitution - Missense	Salivary_gland
COSM1451628	c.162G>T	p.V54V	Substitution - coding silent	Large_intestine
COSM1292530	c.164G>C	p.G55A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1755319	c.373G>A	p.E125K	Substitution - Missense	Urinary_tract
COSM4171674	c.33C>G	p.D11E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5714267	c.142G>A	p.G48S	Substitution - Missense	Skin
COSM242793	c.400G>A	p.V134I	Substitution - Missense	Prostate
COSM5725715	c.189C>T	p.G63G	Substitution - coding silent	Skin
COSM3394837	c.978G>A	p.K326K	Substitution - coding silent	Pancreas
COSM3266876	c.1014C>T	p.S338S	Substitution - coding silent	Large_intestine
COSM3669743	c.124-1G>T	p.?	Unknown	Liver
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1660378	c.770G>C	p.C257S	Substitution - Missense	Kidney
COSM1741423	c.757G>A	p.E253K	Substitution - Missense	Urinary_tract
COSM1755317	c.669C>A	p.F223L	Substitution - Missense	Urinary_tract
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM5926580	c.133G>A	p.V45M	Substitution - Missense	Skin
COSM453255	c.1004G>C	p.R335P	Substitution - Missense	Breast
COSM3881871	c.864C>T	p.D288D	Substitution - coding silent	Stomach
COSM5101420	c.363+2T>C	p.?	Unknown	Large_intestine
COSM1313190	c.472G>A	p.G158R	Substitution - Missense	Urinary_tract
COSM3881870	c.881A>G	p.Y294C	Substitution - Missense	Stomach
COSM4420798	c.145C>T	p.Q49*	Substitution - Nonsense	Prostate
COSM3639802	c.340G>A	p.A114T	Substitution - Missense	Skin
COSM3881872	c.658G>A	p.A220T	Substitution - Missense	Large_intestine
COSM1673019	c.776A>C	p.E259A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5947371	c.3G>A	p.M1I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM367740	c.272A>G	p.Y91C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3685189	c.124-1G>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3374656	c.598T>G	p.F200V	Substitution - Missense	Thyroid
COSM225589	c.155C>T	p.S52F	Substitution - Missense	Skin
COSM4162319	c.703T>C	p.S235P	Substitution - Missense	Thyroid
COSM3639804	c.99C>T	p.S33S	Substitution - coding silent	Skin
COSM3639806	c.77C>T	p.A26V	Substitution - Missense	Skin
COSM3358151	c.59G>C	p.G20A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM238669	c.778G>A	p.A260T	Substitution - Missense	Prostate
COSM298043	c.1114C>T	p.R372C	Substitution - Missense	Large_intestine
COSM5997558	c.54G>A	p.K18K	Substitution - coding silent	Prostate
COSM367740	c.272A>G	p.Y91C	Substitution - Missense	Lung
COSM1755320	c.147G>A	p.Q49Q	Substitution - coding silent	Urinary_tract
COSM5043885	c.223A>G	p.I75V	Substitution - Missense	Liver
COSM1161683	c.77C>A	p.A26D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3995650	c.478A>G	p.T160A	Substitution - Missense	Kidney
COSM3881877	c.137G>T	p.G46V	Substitution - Missense	Stomach
COSM1313190	c.472G>A	p.G158R	Substitution - Missense	Urinary_tract

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
15555571	mutation	Ito Cell Tumor	Pericytoma with t(7;12) is a newly defined soft tissue tumor characterized by fusion of the ACTB and GLI genes through the translocation t(7;12)(p22;q13).
15111311	mutation	Ito Cell Tumor	Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericytic neoplasms: pericytoma with t(7;12).
7067038	mutation	Fibroblastic Neoplasm	HUT-14 fibroblasts express a mutation in one of the two functional beta-actin genes and possess properties that distinguish them as neoplastic cells.
7074877	mutation	Fibroblastic Neoplasm	We found that the neoplastic HUT-14 fibroblasts express a mutation in one of the two functional beta-actin genes.
3380097	underexpression (mutation)	Fibroblastic Neoplasm	HuT-14T is a highly tumorigenic fibroblast cell line which exhibits a reduced steady-state level of beta-actin due to coding mutations in one of two beta-actin alleles.
3374511	underexpression (mutation)	Fibroblastic Neoplasm	The HuT-14 substrain expresses a defective beta-actin as a consequence of a point mutation in 1 of the 2 functional beta-actin alleles.

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P60709	2	D	N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed	-	No	None detected
P60709	44	M	Methionine (R)-sulfoxide	-	No	None detected
P60709	47	M	Methionine (R)-sulfoxide	-	No	None detected
P60709	73	H	Tele-methylhistidine	-	No	None detected
P60709	84	K	N6-methyllysine	-	No	None detected

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	12.937	12.429	-0.531	0.00166	NS
BRCA	Breast invasive carcinoma	112	1100	11.799	12.224	0.434	1.73e-14	NS
CESC	Cervical and endocervical cancers	3	306	13.058	12.385	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	12.676	12.527	-0.143	0.125	NS
ESCA	Esophageal carcinoma	11	185	12.383	12.699	0.393	0.0474	NS
GBM	Glioblastoma multiforme	5	166	11.773	12.732	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	12.352	12.519	0.189	0.0409	NS
KIRC	Kidney renal clear cell carcinoma	72	534	11.53	11.983	0.396	4.44e-10	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	11.701	12.278	0.535	8.41e-10	NS
LAML	Acute Myeloid Leukemia	0	173	NA	12.259	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	11.916	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	11.258	11.16	-0.061	0.477	NS
LUAD	Lung adenocarcinoma	59	517	12.601	12.459	-0.121	0.0904	NS
LUSC	Lung squamous cell carcinoma	51	501	12.617	12.332	-0.265	0.000734	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	12.371	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	12.772	12.442	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	11.443	11.233	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	11.998	11.59	-0.524	2.14e-13	NS
READ	Rectum adenocarcinoma	10	167	12.841	12.514	-0.139	0.528	NS
SARC	Sarcoma	2	263	12.778	12.772	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	13.19	12.407	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	13.018	12.858	-0.347	0.00134	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	12.45	NA	NA	NA
THCA	Thyroid carcinoma	59	509	11.721	11.689	-0.163	0.0262	NS
THYM	Thymoma	2	120	12.6	12.605	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	12.509	12.543	-0.004	0.976	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	12
Autonomic ganglia	CHP212	13
Autonomic ganglia	IMR32	12.8
Autonomic ganglia	KELLY	12.7
Autonomic ganglia	KPNRTBM1	12.7
Autonomic ganglia	KPNSI9S	13.5
Autonomic ganglia	KPNYN	12.4
Autonomic ganglia	MHHNB11	11.5
Autonomic ganglia	NB1	13.4
Autonomic ganglia	NH6	12.6
Autonomic ganglia	SHSY5Y	12.1
Autonomic ganglia	SIMA	12.7
Autonomic ganglia	SKNAS	13.3
Autonomic ganglia	SKNBE2	12.3
Autonomic ganglia	SKNDZ	12.3
Autonomic ganglia	SKNFI	13.1
Autonomic ganglia	SKNSH	13.6
Biliary tract	HUCCT1	13.4
Biliary tract	HUH28	13.3
Biliary tract	SNU1079	13.4
Biliary tract	SNU1196	13.2
Biliary tract	SNU245	12.9
Biliary tract	SNU308	12.9
Biliary tract	SNU478	13.5
Bone	143B	12.7
Bone	A673	13
Bone	CADOES1	12.9
Bone	CAL78	13.3
Bone	G292CLONEA141B1	13.2
Bone	HOS	13.2
Bone	HS706T	13.3
Bone	HS737T	13.1
Bone	HS819T	13
Bone	HS821T	13.8
Bone	HS822T	13.2
Bone	HS863T	13.8
Bone	HS870T	13
Bone	HS888T	13.8
Bone	MG63	12.8
Bone	MHHES1	12
Bone	OUMS27	13.2
Bone	RDES	12.6
Bone	SJSA1	13.7
Bone	SKES1	13.3
Bone	SKNMC	12.8
Bone	SW1353	13.4
Bone	T173	13.2
Bone	TC71	11.8
Bone	U2OS	13.7
Breast	AU565	13.5
Breast	BT20	13.6
Breast	BT474	12.9
Breast	BT483	13.6
Breast	BT549	14.1
Breast	CAL120	13.5
Breast	CAL148	13.1
Breast	CAL51	13.7
Breast	CAL851	13.6
Breast	CAMA1	12.9
Breast	DU4475	12.4
Breast	EFM192A	13.4
Breast	EFM19	13.2
Breast	EVSAT	13.1
Breast	HCC1143	13.3
Breast	HCC1187	13.4
Breast	HCC1395	13.4
Breast	HCC1419	13.5
Breast	HCC1428	13.3
Breast	HCC1500	12.1
Breast	HCC1569	12.8
Breast	HCC1599	12.1
Breast	HCC1806	12.5
Breast	HCC1937	13.1
Breast	HCC1954	13.2
Breast	HCC202	13.1
Breast	HCC2157	12.2
Breast	HCC2218	12.7
Breast	HCC38	12.5
Breast	HCC70	12.9
Breast	HDQP1	13.1
Breast	HMC18	13.4
Breast	HS274T	13.8
Breast	HS281T	14
Breast	HS343T	13.9
Breast	HS578T	14
Breast	HS606T	13.6
Breast	HS739T	13.3
Breast	HS742T	13.1
Breast	JIMT1	13.6
Breast	KPL1	13.3
Breast	MCF7	12.5
Breast	MDAMB134VI	11.7
Breast	MDAMB157	12.8
Breast	MDAMB175VII	12.8
Breast	MDAMB231	13.3
Breast	MDAMB361	13.3
Breast	MDAMB415	12.3
Breast	MDAMB436	13.7
Breast	MDAMB453	13.2
Breast	MDAMB468	13.9
Breast	SKBR3	13
Breast	T47D	13
Breast	UACC812	12.1
Breast	UACC893	13.5
Breast	YMB1	12.5
Breast	ZR751	11.8
Breast	ZR7530	13.5
Central nervous system	1321N1	13.7
Central nervous system	42MGBA	13.8
Central nervous system	8MGBA	13
Central nervous system	A172	13.9
Central nervous system	AM38	12.6
Central nervous system	BECKER	13.2
Central nervous system	CAS1	13.3
Central nervous system	CCFSTTG1	13.5
Central nervous system	D283MED	12.6
Central nervous system	D341MED	11.3
Central nervous system	DAOY	13.3
Central nervous system	DBTRG05MG	13.6
Central nervous system	DKMG	12.1
Central nervous system	GAMG	13.6
Central nervous system	GB1	14.3
Central nervous system	GI1	13.8
Central nervous system	GMS10	13.8
Central nervous system	GOS3	13.3
Central nervous system	H4	13.6
Central nervous system	HS683	13.1
Central nervous system	KALS1	13.6
Central nervous system	KG1C	13
Central nervous system	KNS42	13.4
Central nervous system	KNS60	13.1
Central nervous system	KNS81	13.8
Central nervous system	KS1	13.4
Central nervous system	LN18	13.7
Central nervous system	LN229	13.2
Central nervous system	M059K	13.9
Central nervous system	MOGGCCM	14.1
Central nervous system	MOGGUVW	13.6
Central nervous system	NMCG1	13.9
Central nervous system	ONS76	11.9
Central nervous system	SF126	13.6
Central nervous system	SF295	13.7
Central nervous system	SNB19	13.9
Central nervous system	SNU1105	13.9
Central nervous system	SNU201	13.7
Central nervous system	SNU466	13.8
Central nervous system	SNU489	14.2
Central nervous system	SNU626	13.3
Central nervous system	SNU738	13.9
Central nervous system	SW1088	13.2
Central nervous system	SW1783	13.3
Central nervous system	T98G	13.6
Central nervous system	TM31	13.1
Central nervous system	U118MG	14.1
Central nervous system	U138MG	13.3
Central nervous system	U251MG	13.7
Central nervous system	U87MG	13.8
Central nervous system	YH13	13.8
Central nervous system	YKG1	13.1
Endometrium	AN3CA	13.7
Endometrium	COLO684	13.4
Endometrium	EFE184	12.3
Endometrium	EN	12.6
Endometrium	ESS1	13.5
Endometrium	HEC108	12.7
Endometrium	HEC151	12.9
Endometrium	HEC1A	13.6
Endometrium	HEC1B	12.9
Endometrium	HEC251	13.2
Endometrium	HEC265	13.2
Endometrium	HEC50B	13
Endometrium	HEC59	13
Endometrium	HEC6	13.1
Endometrium	ISHIKAWAHERAKLIO02ER	11.8
Endometrium	JHUEM1	13.6
Endometrium	JHUEM2	13.4
Endometrium	JHUEM3	12.4
Endometrium	KLE	13.1
Endometrium	MFE280	12.8
Endometrium	MFE296	13.7
Endometrium	MFE319	12.7
Endometrium	RL952	13.1
Endometrium	SNGM	12.4
Endometrium	SNU1077	12.6
Endometrium	SNU685	14
Endometrium	TEN	13
Haematopoietic and lymphoid	697	13.5
Haematopoietic and lymphoid	A3KAW	12.1
Haematopoietic and lymphoid	A4FUK	12.5
Haematopoietic and lymphoid	ALLSIL	13.5
Haematopoietic and lymphoid	AML193	12.8
Haematopoietic and lymphoid	AMO1	13.1
Haematopoietic and lymphoid	BCP1	13.2
Haematopoietic and lymphoid	BDCM	13.9
Haematopoietic and lymphoid	BL41	13.2
Haematopoietic and lymphoid	BL70	12.8
Haematopoietic and lymphoid	BV173	12.4
Haematopoietic and lymphoid	CA46	12.1
Haematopoietic and lymphoid	CI1	13.2
Haematopoietic and lymphoid	CMK115	13.2
Haematopoietic and lymphoid	CMK86	14.1
Haematopoietic and lymphoid	CMK	13.5
Haematopoietic and lymphoid	CMLT1	13.2
Haematopoietic and lymphoid	COLO775	13.6
Haematopoietic and lymphoid	DAUDI	13.3
Haematopoietic and lymphoid	DB	13.2
Haematopoietic and lymphoid	DEL	13.8
Haematopoietic and lymphoid	DND41	13.7
Haematopoietic and lymphoid	DOHH2	13.6
Haematopoietic and lymphoid	EB1	13.2
Haematopoietic and lymphoid	EB2	13.2
Haematopoietic and lymphoid	EHEB	14
Haematopoietic and lymphoid	EJM	12.9
Haematopoietic and lymphoid	EM2	13.2
Haematopoietic and lymphoid	EOL1	13.4
Haematopoietic and lymphoid	F36P	13
Haematopoietic and lymphoid	GA10	13.3
Haematopoietic and lymphoid	GDM1	13.6
Haematopoietic and lymphoid	GRANTA519	13.3
Haematopoietic and lymphoid	HDLM2	13.5
Haematopoietic and lymphoid	HDMYZ	13.3
Haematopoietic and lymphoid	HEL9217	13.2
Haematopoietic and lymphoid	HEL	12.6
Haematopoietic and lymphoid	HH	13.8
Haematopoietic and lymphoid	HL60	12.4
Haematopoietic and lymphoid	HPBALL	13.5
Haematopoietic and lymphoid	HS604T	13.5
Haematopoietic and lymphoid	HS611T	13.5
Haematopoietic and lymphoid	HS616T	13.1
Haematopoietic and lymphoid	HS751T	12.5
Haematopoietic and lymphoid	HT	13.1
Haematopoietic and lymphoid	HTK	13.9
Haematopoietic and lymphoid	HUNS1	13.5
Haematopoietic and lymphoid	HUT102	13.6
Haematopoietic and lymphoid	HUT78	12.6
Haematopoietic and lymphoid	JEKO1	13.4
Haematopoietic and lymphoid	JK1	13
Haematopoietic and lymphoid	JM1	13.2
Haematopoietic and lymphoid	JURKAT	12.9
Haematopoietic and lymphoid	JURLMK1	12.9
Haematopoietic and lymphoid	JVM2	13.9
Haematopoietic and lymphoid	JVM3	13.7
Haematopoietic and lymphoid	K562	13.2
Haematopoietic and lymphoid	KARPAS299	11.8
Haematopoietic and lymphoid	KARPAS422	13.1
Haematopoietic and lymphoid	KARPAS620	13.3
Haematopoietic and lymphoid	KASUMI1	11
Haematopoietic and lymphoid	KASUMI2	13.3
Haematopoietic and lymphoid	KASUMI6	13.2
Haematopoietic and lymphoid	KCL22	13.1
Haematopoietic and lymphoid	KE37	13.4
Haematopoietic and lymphoid	KE97	13.5
Haematopoietic and lymphoid	KG1	12.9
Haematopoietic and lymphoid	KHM1B	12
Haematopoietic and lymphoid	KIJK	13.3
Haematopoietic and lymphoid	KMH2	13.4
Haematopoietic and lymphoid	KMM1	12.5
Haematopoietic and lymphoid	KMS11	12.9
Haematopoietic and lymphoid	KMS12BM	12.7
Haematopoietic and lymphoid	KMS18	13.4
Haematopoietic and lymphoid	KMS20	12.6
Haematopoietic and lymphoid	KMS21BM	11.8
Haematopoietic and lymphoid	KMS26	11.5
Haematopoietic and lymphoid	KMS27	12.3
Haematopoietic and lymphoid	KMS28BM	11.4
Haematopoietic and lymphoid	KMS34	11.8
Haematopoietic and lymphoid	KO52	12.8
Haematopoietic and lymphoid	KOPN8	14
Haematopoietic and lymphoid	KU812	13.4
Haematopoietic and lymphoid	KYO1	12.9
Haematopoietic and lymphoid	L1236	13.5
Haematopoietic and lymphoid	L363	13
Haematopoietic and lymphoid	L428	14.2
Haematopoietic and lymphoid	L540	12.9
Haematopoietic and lymphoid	LAMA84	12.8
Haematopoietic and lymphoid	LOUCY	13.4
Haematopoietic and lymphoid	LP1	12.1
Haematopoietic and lymphoid	M07E	13.5
Haematopoietic and lymphoid	MC116	13.2
Haematopoietic and lymphoid	ME1	13.5
Haematopoietic and lymphoid	MEC1	13.5
Haematopoietic and lymphoid	MEC2	14
Haematopoietic and lymphoid	MEG01	12.6
Haematopoietic and lymphoid	MHHCALL2	13.8
Haematopoietic and lymphoid	MHHCALL3	13.4
Haematopoietic and lymphoid	MHHCALL4	13.3
Haematopoietic and lymphoid	MINO	13.9
Haematopoietic and lymphoid	MJ	13.7
Haematopoietic and lymphoid	MM1S	13.3
Haematopoietic and lymphoid	MOLM13	13.7
Haematopoietic and lymphoid	MOLM16	13.6
Haematopoietic and lymphoid	MOLM6	13.3
Haematopoietic and lymphoid	MOLP2	11.7
Haematopoietic and lymphoid	MOLP8	12.5
Haematopoietic and lymphoid	MOLT13	13.6
Haematopoietic and lymphoid	MOLT16	13.4
Haematopoietic and lymphoid	MOLT4	13.1
Haematopoietic and lymphoid	MONOMAC1	13.3
Haematopoietic and lymphoid	MONOMAC6	13
Haematopoietic and lymphoid	MOTN1	13.8
Haematopoietic and lymphoid	MUTZ5	13.3
Haematopoietic and lymphoid	MV411	13.4
Haematopoietic and lymphoid	NALM19	13.5
Haematopoietic and lymphoid	NALM1	12.9
Haematopoietic and lymphoid	NALM6	12.8
Haematopoietic and lymphoid	NAMALWA	13.6
Haematopoietic and lymphoid	NB4	13.6
Haematopoietic and lymphoid	NCIH929	11.3
Haematopoietic and lymphoid	NCO2	12.8
Haematopoietic and lymphoid	NOMO1	13.8
Haematopoietic and lymphoid	NUDHL1	13.5
Haematopoietic and lymphoid	NUDUL1	13.7
Haematopoietic and lymphoid	OCIAML2	13.2
Haematopoietic and lymphoid	OCIAML3	13.5
Haematopoietic and lymphoid	OCIAML5	13.5
Haematopoietic and lymphoid	OCILY10	12.7
Haematopoietic and lymphoid	OCILY19	13.5
Haematopoietic and lymphoid	OCILY3	12.5
Haematopoietic and lymphoid	OCIM1	13.3
Haematopoietic and lymphoid	OPM2	11.5
Haematopoietic and lymphoid	P12ICHIKAWA	13.5
Haematopoietic and lymphoid	P31FUJ	12.6
Haematopoietic and lymphoid	P3HR1	12.9
Haematopoietic and lymphoid	PCM6	13.4
Haematopoietic and lymphoid	PEER	13.5
Haematopoietic and lymphoid	PF382	13.1
Haematopoietic and lymphoid	PFEIFFER	13.2
Haematopoietic and lymphoid	PL21	13.2
Haematopoietic and lymphoid	RAJI	13
Haematopoietic and lymphoid	RCHACV	13.3
Haematopoietic and lymphoid	REC1	13.5
Haematopoietic and lymphoid	REH	12.8
Haematopoietic and lymphoid	RI1	13.6
Haematopoietic and lymphoid	RL	13.6
Haematopoietic and lymphoid	RPMI8226	12.4
Haematopoietic and lymphoid	RPMI8402	13.1
Haematopoietic and lymphoid	RS411	13.1
Haematopoietic and lymphoid	SEM	13.3
Haematopoietic and lymphoid	SET2	13.5
Haematopoietic and lymphoid	SIGM5	13.6
Haematopoietic and lymphoid	SKM1	12.9
Haematopoietic and lymphoid	SKMM2	11.9
Haematopoietic and lymphoid	SR786	13.5
Haematopoietic and lymphoid	ST486	12.7
Haematopoietic and lymphoid	SUDHL10	13.6
Haematopoietic and lymphoid	SUDHL1	13.4
Haematopoietic and lymphoid	SUDHL4	13.7
Haematopoietic and lymphoid	SUDHL5	13.6
Haematopoietic and lymphoid	SUDHL6	13.7
Haematopoietic and lymphoid	SUDHL8	12.3
Haematopoietic and lymphoid	SUPB15	12.8
Haematopoietic and lymphoid	SUPHD1	13.8
Haematopoietic and lymphoid	SUPM2	12
Haematopoietic and lymphoid	SUPT11	13.7
Haematopoietic and lymphoid	SUPT1	12.9
Haematopoietic and lymphoid	TALL1	12.9
Haematopoietic and lymphoid	TF1	13.3
Haematopoietic and lymphoid	THP1	13.7
Haematopoietic and lymphoid	TO175T	12.7
Haematopoietic and lymphoid	TOLEDO	12.5
Haematopoietic and lymphoid	U266B1	12.3
Haematopoietic and lymphoid	U937	12.7
Haematopoietic and lymphoid	UT7	13.2
Haematopoietic and lymphoid	WSUDLCL2	13.7
Kidney	769P	13.7
Kidney	786O	14
Kidney	A498	13.7
Kidney	A704	11
Kidney	ACHN	13.4
Kidney	BFTC909	13.5
Kidney	CAKI1	12.7
Kidney	CAKI2	13.5
Kidney	CAL54	13.3
Kidney	KMRC1	13.2
Kidney	KMRC20	12.1
Kidney	KMRC2	13.6
Kidney	KMRC3	13
Kidney	OSRC2	13.2
Kidney	RCC10RGB	12.9
Kidney	SNU1272	13.2
Kidney	SNU349	14.2
Kidney	TUHR10TKB	13.5
Kidney	TUHR14TKB	12.8
Kidney	TUHR4TKB	13.2
Kidney	VMRCRCW	12.6
Kidney	VMRCRCZ	12.9
Large intestine	C2BBE1	13.8
Large intestine	CCK81	13.1
Large intestine	CL11	13.7
Large intestine	CL14	13.2
Large intestine	CL34	13.6
Large intestine	CL40	13.4
Large intestine	COLO205	12
Large intestine	COLO320	12.8
Large intestine	COLO678	13
Large intestine	CW2	12.9
Large intestine	DLD1	13.3
Large intestine	GP2D	11.2
Large intestine	HCC56	12
Large intestine	HCT116	13.3
Large intestine	HCT15	13.3
Large intestine	HS675T	13.2
Large intestine	HS698T	13.6
Large intestine	HT115	13.4
Large intestine	HT29	13.6
Large intestine	HT55	11.3
Large intestine	KM12	12.5
Large intestine	LOVO	13.1
Large intestine	LS1034	12.5
Large intestine	LS123	13
Large intestine	LS180	13.3
Large intestine	LS411N	13
Large intestine	LS513	11.3
Large intestine	MDST8	13.1
Large intestine	NCIH508	11.6
Large intestine	NCIH716	12.8
Large intestine	NCIH747	13.2
Large intestine	OUMS23	12.4
Large intestine	RCM1	12.1
Large intestine	RKO	11.2
Large intestine	SKCO1	10.9
Large intestine	SNU1040	12.7
Large intestine	SNU1197	12.7
Large intestine	SNU175	12.3
Large intestine	SNU283	13.4
Large intestine	SNU407	12.8
Large intestine	SNU503	12.5
Large intestine	SNU61	13
Large intestine	SNU81	13.9
Large intestine	SNUC1	11.8
Large intestine	SNUC2A	12.8
Large intestine	SNUC4	12.8
Large intestine	SNUC5	13.4
Large intestine	SW1116	12.1
Large intestine	SW1417	13.1
Large intestine	SW1463	12.6
Large intestine	SW403	12.6
Large intestine	SW480	12.7
Large intestine	SW48	12.6
Large intestine	SW620	13.5
Large intestine	SW837	10.4
Large intestine	SW948	12.9
Large intestine	T84	13.7
Liver	ALEXANDERCELLS	12.9
Liver	C3A	12.4
Liver	HEP3B217	13.6
Liver	HEPG2	13.3
Liver	HLE	12.8
Liver	HLF	13.4
Liver	HUH1	13.2
Liver	HUH6	12.6
Liver	HUH7	12.9
Liver	JHH1	12.9
Liver	JHH2	14.2
Liver	JHH4	13.4
Liver	JHH5	13.2
Liver	JHH6	11.6
Liver	JHH7	12.6
Liver	LI7	12.8
Liver	PLCPRF5	12.6
Liver	SKHEP1	11.8
Liver	SNU182	13.5
Liver	SNU387	13.8
Liver	SNU398	13.1
Liver	SNU423	13.7
Liver	SNU449	13.4
Liver	SNU475	13.7
Liver	SNU761	13.6
Liver	SNU878	13.1
Liver	SNU886	14.4
Lung	A549	13.7
Lung	ABC1	13.5
Lung	BEN	12.7
Lung	CAL12T	13.3
Lung	CALU1	13.9
Lung	CALU3	13.5
Lung	CALU6	13.4
Lung	CHAGOK1	10.8
Lung	COLO668	11.9
Lung	COLO699	12.7
Lung	CORL105	12.9
Lung	CORL23	12.8
Lung	CORL24	10.7
Lung	CORL279	13.9
Lung	CORL311	11
Lung	CORL47	11.4
Lung	CORL51	11.5
Lung	CORL88	11.1
Lung	CORL95	11.5
Lung	CPCN	11.3
Lung	DMS114	12.4
Lung	DMS153	12.1
Lung	DMS273	11.7
Lung	DMS454	9.3
Lung	DMS53	11.6
Lung	DMS79	13
Lung	DV90	12.5
Lung	EBC1	12.9
Lung	EPLC272H	13.6
Lung	HARA	12.9
Lung	HCC1171	13.3
Lung	HCC1195	13.4
Lung	HCC15	13
Lung	HCC2279	13.8
Lung	HCC2935	13.5
Lung	HCC33	12.2
Lung	HCC366	12.2
Lung	HCC4006	13.8
Lung	HCC44	13.2
Lung	HCC78	13.1
Lung	HCC827	13.6
Lung	HCC95	11.1
Lung	HLC1	12.5
Lung	HLFA	13.7
Lung	HS229T	13.4
Lung	HS618T	13.5
Lung	IALM	13.1
Lung	KNS62	12.9
Lung	LC1F	11.6
Lung	LC1SQSF	10.5
Lung	LCLC103H	13.8
Lung	LCLC97TM1	13.3
Lung	LK2	13.2
Lung	LOUNH91	13.8
Lung	LU65	13
Lung	LU99	13
Lung	LUDLU1	12.5
Lung	LXF289	13.2
Lung	MORCPR	12.6
Lung	NCIH1048	12.3
Lung	NCIH1092	10.5
Lung	NCIH1105	10.6
Lung	NCIH1155	13.6
Lung	NCIH1184	12.3
Lung	NCIH1299	13.5
Lung	NCIH1339	12
Lung	NCIH1341	13.1
Lung	NCIH1355	13.4
Lung	NCIH1373	11.8
Lung	NCIH1385	12.2
Lung	NCIH1395	12.1
Lung	NCIH1435	13.1
Lung	NCIH1436	11.1
Lung	NCIH1437	12.4
Lung	NCIH146	13.4
Lung	NCIH1563	13.3
Lung	NCIH1568	13.2
Lung	NCIH1573	11.2
Lung	NCIH1581	12.2
Lung	NCIH1618	12.4
Lung	NCIH1623	12
Lung	NCIH1648	12.2
Lung	NCIH1650	13.6
Lung	NCIH1651	13.3
Lung	NCIH1666	12.3
Lung	NCIH1693	12
Lung	NCIH1694	12.5
Lung	NCIH1703	13.4
Lung	NCIH1734	12.6
Lung	NCIH1755	12.9
Lung	NCIH1781	13.3
Lung	NCIH1792	13.5
Lung	NCIH1793	13.4
Lung	NCIH1836	12.3
Lung	NCIH1838	13
Lung	NCIH1869	13.7
Lung	NCIH1876	10.8
Lung	NCIH1915	12.1
Lung	NCIH1930	12
Lung	NCIH1944	13.2
Lung	NCIH1963	12.5
Lung	NCIH196	14
Lung	NCIH1975	13.7
Lung	NCIH2009	13.5
Lung	NCIH2023	12.8
Lung	NCIH2029	11.5
Lung	NCIH2030	13.7
Lung	NCIH2066	12.2
Lung	NCIH2081	10.6
Lung	NCIH2085	13.3
Lung	NCIH2087	13.1
Lung	NCIH209	13.3
Lung	NCIH2106	12.9
Lung	NCIH2110	11.7
Lung	NCIH211	13.4
Lung	NCIH2122	13.3
Lung	NCIH2126	12.2
Lung	NCIH2141	12.8
Lung	NCIH2170	13.4
Lung	NCIH2171	13.4
Lung	NCIH2172	11.6
Lung	NCIH2196	13.4
Lung	NCIH2227	10.8
Lung	NCIH2228	13.5
Lung	NCIH226	12.9
Lung	NCIH2286	11.6
Lung	NCIH2291	13.5
Lung	NCIH2342	12.7
Lung	NCIH2347	13.2
Lung	NCIH23	13.1
Lung	NCIH2405	13.2
Lung	NCIH2444	13.6
Lung	NCIH292	14.2
Lung	NCIH322	13.1
Lung	NCIH3255	14.1
Lung	NCIH358	12.8
Lung	NCIH441	13.2
Lung	NCIH446	13.7
Lung	NCIH460	13.1
Lung	NCIH510	12.2
Lung	NCIH520	13.1
Lung	NCIH522	13.4
Lung	NCIH524	12.8
Lung	NCIH526	13.1
Lung	NCIH596	11.7
Lung	NCIH647	13.3
Lung	NCIH650	11.9
Lung	NCIH661	13.4
Lung	NCIH69	12
Lung	NCIH727	13.5
Lung	NCIH810	12.7
Lung	NCIH82	12.8
Lung	NCIH838	12.4
Lung	NCIH841	13.6
Lung	NCIH854	12.8
Lung	NCIH889	13
Lung	PC14	13.1
Lung	RERFLCAD1	13
Lung	RERFLCAD2	12.9
Lung	RERFLCAI	13.5
Lung	RERFLCKJ	12.2
Lung	RERFLCMS	12.9
Lung	RERFLCSQ1	13.9
Lung	SBC5	13.4
Lung	SCLC21H	12.5
Lung	SHP77	13.7
Lung	SKLU1	13.4
Lung	SKMES1	13.4
Lung	SQ1	13.8
Lung	SW1271	13.6
Lung	SW1573	11.6
Lung	SW900	13.3
Lung	VMRCLCD	13.4
Lung	VMRCLCP	12
Oesophagus	COLO680N	13
Oesophagus	ECGI10	12.4
Oesophagus	KYSE140	12.9
Oesophagus	KYSE150	13.6
Oesophagus	KYSE180	12.6
Oesophagus	KYSE270	12.6
Oesophagus	KYSE30	12.8
Oesophagus	KYSE410	13.3
Oesophagus	KYSE450	11.8
Oesophagus	KYSE510	13.3
Oesophagus	KYSE520	12.9
Oesophagus	KYSE70	12.5
Oesophagus	OE19	12.9
Oesophagus	OE33	11.1
Oesophagus	TE10	12.4
Oesophagus	TE11	13
Oesophagus	TE14	11.1
Oesophagus	TE15	13
Oesophagus	TE1	13.9
Oesophagus	TE4	13.4
Oesophagus	TE5	11.9
Oesophagus	TE6	12.5
Oesophagus	TE8	13.3
Oesophagus	TE9	13.3
Oesophagus	TT	11.4
Ovary	59M	13.5
Ovary	A2780	13.7
Ovary	CAOV3	13.8
Ovary	CAOV4	12.4
Ovary	COLO704	13.4
Ovary	COV318	12.6
Ovary	COV362	11.6
Ovary	COV434	12.7
Ovary	COV504	13.3
Ovary	COV644	12.3
Ovary	EFO21	12.9
Ovary	EFO27	13.8
Ovary	ES2	13
Ovary	FUOV1	12.9
Ovary	HEYA8	13.3
Ovary	HS571T	13.6
Ovary	IGROV1	13.9
Ovary	JHOC5	13
Ovary	JHOM1	13.1
Ovary	JHOM2B	13.6
Ovary	JHOS2	11.4
Ovary	JHOS4	12.1
Ovary	KURAMOCHI	13.6
Ovary	MCAS	13.7
Ovary	NIHOVCAR3	12.9
Ovary	OAW28	11.5
Ovary	OAW42	12.3
Ovary	OC314	12.6
Ovary	OC316	12.9
Ovary	ONCODG1	13.2
Ovary	OV56	11.4
Ovary	OV7	12.6
Ovary	OV90	11.8
Ovary	OVCAR4	13
Ovary	OVCAR8	12.3
Ovary	OVISE	13.1
Ovary	OVK18	13.1
Ovary	OVKATE	12
Ovary	OVMANA	10.1
Ovary	OVSAHO	12.7
Ovary	OVTOKO	12.8
Ovary	RMGI	12.5
Ovary	RMUGS	13.3
Ovary	SKOV3	13.1
Ovary	SNU119	13
Ovary	SNU840	13.6
Ovary	SNU8	13.5
Ovary	TOV112D	13.5
Ovary	TOV21G	13.6
Ovary	TYKNU	13.7
Pancreas	ASPC1	13.6
Pancreas	BXPC3	13.6
Pancreas	CAPAN1	12.6
Pancreas	CAPAN2	13.7
Pancreas	CFPAC1	12.9
Pancreas	DANG	13.4
Pancreas	HPAC	12.1
Pancreas	HPAFII	13.1
Pancreas	HS766T	13.4
Pancreas	HUPT3	12.4
Pancreas	HUPT4	13.2
Pancreas	KCIMOH1	12.8
Pancreas	KLM1	14.2
Pancreas	KP2	12.8
Pancreas	KP3	13.1
Pancreas	KP4	12.5
Pancreas	L33	12.7
Pancreas	MIAPACA2	13.1
Pancreas	PANC0203	12.7
Pancreas	PANC0213	13.1
Pancreas	PANC0327	12.7
Pancreas	PANC0403	13.3
Pancreas	PANC0504	13
Pancreas	PANC0813	12.8
Pancreas	PANC1005	13.6
Pancreas	PANC1	12.7
Pancreas	PATU8902	12.7
Pancreas	PATU8988S	12.3
Pancreas	PATU8988T	13.6
Pancreas	PK1	12.9
Pancreas	PK45H	13.3
Pancreas	PK59	13.2
Pancreas	PL45	12.7
Pancreas	PSN1	13.1
Pancreas	QGP1	12.4
Pancreas	SNU213	13
Pancreas	SNU324	12.7
Pancreas	SNU410	13.6
Pancreas	SU8686	12.1
Pancreas	SUIT2	11.7
Pancreas	SW1990	12.6
Pancreas	T3M4	12.8
Pancreas	TCCPAN2	13.3
Pancreas	YAPC	11.6
Pleura	ACCMESO1	12.7
Pleura	DM3	13.9
Pleura	ISTMES1	13
Pleura	ISTMES2	12.6
Pleura	JL1	13.7
Pleura	MPP89	13
Pleura	MSTO211H	12.6
Pleura	NCIH2052	13.3
Pleura	NCIH2452	12.7
Pleura	NCIH28	12.4
Prostate	22RV1	12.7
Prostate	DU145	13.6
Prostate	LNCAPCLONEFGC	12.5
Prostate	MDAPCA2B	12.9
Prostate	NCIH660	11.9
Prostate	PC3	13.4
Prostate	VCAP	12.3
Salivary gland	A253	11.6
Salivary gland	YD15	12.9
Skin	A101D	12.7
Skin	A2058	14.1
Skin	A375	13.4
Skin	C32	12.7
Skin	CHL1	13.5
Skin	CJM	12.3
Skin	COLO679	13.3
Skin	COLO741	13.1
Skin	COLO783	11.6
Skin	COLO792	11.8
Skin	COLO800	13
Skin	COLO818	13
Skin	COLO829	12.9
Skin	COLO849	12.3
Skin	G361	13.5
Skin	GRM	13.9
Skin	HMCB	13.9
Skin	HS294T	13.4
Skin	HS600T	13.1
Skin	HS688AT	13.5
Skin	HS695T	13.9
Skin	HS839T	13.1
Skin	HS852T	12.9
Skin	HS895T	13
Skin	HS934T	13.8
Skin	HS936T	12.5
Skin	HS939T	12.9
Skin	HS940T	13.3
Skin	HS944T	13.5
Skin	HT144	12.5
Skin	IGR1	12.1
Skin	IGR37	13.9
Skin	IGR39	13.4
Skin	IPC298	13.8
Skin	K029AX	13.3
Skin	LOXIMVI	13.5
Skin	MALME3M	13.4
Skin	MDAMB435S	11.8
Skin	MELHO	13.1
Skin	MELJUSO	13.7
Skin	MEWO	11.5
Skin	RPMI7951	12.5
Skin	RVH421	12.8
Skin	SH4	12.6
Skin	SKMEL1	12.4
Skin	SKMEL24	13.4
Skin	SKMEL28	12.7
Skin	SKMEL2	12.9
Skin	SKMEL30	12.6
Skin	SKMEL31	12.2
Skin	SKMEL3	13.4
Skin	SKMEL5	13.6
Skin	UACC257	13.3
Skin	UACC62	12.5
Skin	WM115	13.4
Skin	WM1799	12.1
Skin	WM2664	13.4
Skin	WM793	12.7
Skin	WM88	11.8
Skin	WM983B	11.4
Small intestine	HUTU80	11.8
Soft tissue	A204	13
Soft tissue	G401	13.5
Soft tissue	G402	13.7
Soft tissue	GCT	13.3
Soft tissue	HS729	12.8
Soft tissue	HT1080	13.3
Soft tissue	KYM1	12.6
Soft tissue	MESSA	12.8
Soft tissue	RD	13.5
Soft tissue	RH30	14.1
Soft tissue	RH41	12.9
Soft tissue	RKN	13
Soft tissue	S117	13.7
Soft tissue	SJRH30	12.7
Soft tissue	SKLMS1	12.7
Soft tissue	SKUT1	13.4
Soft tissue	TE125T	13.4
Soft tissue	TE159T	12.3
Soft tissue	TE441T	13.2
Soft tissue	TE617T	12.7
Stomach	2313287	13.1
Stomach	AGS	13.5
Stomach	AZ521	12.9
Stomach	ECC10	12.4
Stomach	ECC12	12.2
Stomach	FU97	13.2
Stomach	GCIY	12.9
Stomach	GSS	12.5
Stomach	GSU	12.9
Stomach	HGC27	12.7
Stomach	HS746T	13
Stomach	HUG1N	12.8
Stomach	IM95	13.6
Stomach	KATOIII	13.5
Stomach	KE39	12
Stomach	LMSU	13.5
Stomach	MKN1	13.1
Stomach	MKN45	13.4
Stomach	MKN74	13
Stomach	MKN7	13.8
Stomach	NCCSTCK140	13.9
Stomach	NCIN87	13.2
Stomach	NUGC2	12.8
Stomach	NUGC3	13.8
Stomach	NUGC4	12.3
Stomach	OCUM1	12.7
Stomach	RERFGC1B	12.4
Stomach	SH10TC	13.2
Stomach	SNU16	12.4
Stomach	SNU1	13.1
Stomach	SNU216	13.5
Stomach	SNU520	12.9
Stomach	SNU5	13.4
Stomach	SNU601	14.1
Stomach	SNU620	12.5
Stomach	SNU668	13.9
Stomach	SNU719	13.6
Stomach	TGBC11TKB	12.2
Thyroid	8305C	13.7
Thyroid	8505C	13.9
Thyroid	BCPAP	12.8
Thyroid	BHT101	13.3
Thyroid	CAL62	13.4
Thyroid	CGTHW1	13.6
Thyroid	FTC133	13
Thyroid	FTC238	12.1
Thyroid	ML1	13.4
Thyroid	SW579	14.2
Thyroid	TT2609C02	13.7
Thyroid	TT	12.3
Upper aerodigestive tract	BHY	11.9
Upper aerodigestive tract	BICR16	12.9
Upper aerodigestive tract	BICR18	12.6
Upper aerodigestive tract	BICR22	12.5
Upper aerodigestive tract	BICR31	12.4
Upper aerodigestive tract	BICR56	12.4
Upper aerodigestive tract	BICR6	12.9
Upper aerodigestive tract	CAL27	13.1
Upper aerodigestive tract	CAL33	13.7
Upper aerodigestive tract	DETROIT562	13.9
Upper aerodigestive tract	FADU	13
Upper aerodigestive tract	HS840T	13.3
Upper aerodigestive tract	HSC2	12.7
Upper aerodigestive tract	HSC3	13.2
Upper aerodigestive tract	HSC4	12.6
Upper aerodigestive tract	PECAPJ15	11.4
Upper aerodigestive tract	PECAPJ34CLONEC12	12.5
Upper aerodigestive tract	PECAPJ41CLONED2	11.9
Upper aerodigestive tract	PECAPJ49	12.4
Upper aerodigestive tract	SCC15	13.5
Upper aerodigestive tract	SCC25	13.4
Upper aerodigestive tract	SCC4	13.3
Upper aerodigestive tract	SCC9	12.9
Upper aerodigestive tract	SNU1076	12.5
Upper aerodigestive tract	SNU1214	12.3
Upper aerodigestive tract	SNU46	13.4
Upper aerodigestive tract	SNU899	13.1
Upper aerodigestive tract	YD10B	12.7
Upper aerodigestive tract	YD38	13.6
Upper aerodigestive tract	YD8	13.6
Urinary tract	5637	13.3
Urinary tract	639V	13.7
Urinary tract	647V	14
Urinary tract	BC3C	13.8
Urinary tract	BFTC905	13.2
Urinary tract	CAL29	13.6
Urinary tract	HS172T	13.1
Urinary tract	HT1197	12.1
Urinary tract	HT1376	13.8
Urinary tract	J82	13.5
Urinary tract	JMSU1	13.1
Urinary tract	KMBC2	11.5
Urinary tract	KU1919	13.5
Urinary tract	RT11284	11.5
Urinary tract	RT112	13.4
Urinary tract	RT4	12.9
Urinary tract	SCABER	13.1
Urinary tract	SW1710	13.2
Urinary tract	SW780	11.9
Urinary tract	T24	13.7
Urinary tract	TCCSUP	14.2
Urinary tract	UMUC1	13.8
Urinary tract	UMUC3	12.5
Urinary tract	VMCUB1	12.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	2684.8
Adrenal gland	1194.2
Appendix	5043.1
Bone marrow	2023.8
Breast	884
Cerebral cortex	2243.1
Cervix, uterine	1778.8
Colon	2099.3
Duodenum	1465.8
Endometrium	3469
Epididymis	1243.4
Esophagus	2728.6
Fallopian tube	2065.2
Gallbladder	2382.2
Heart muscle	345.6
Kidney	710.3
Liver	696
Lung	2832.9
Lymph node	4313.6
Ovary	1369
Pancreas	144.1
Parathyroid gland	850.8
Placenta	2200.7
Prostate	2272.9
Rectum	2023
Salivary gland	447
Seminal vesicle	3476.9
Skeletal muscle	85.9
Skin	1131.6
Small intestine	2027.4
Smooth muscle	7124.7
Spleen	3554.6
Stomach	1196.2
Testis	829
Thyroid gland	1725.4
Tonsil	3681.2
Urinary bladder	3035

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27383302	aberrant expression	Malignant Ovarian Neoplasm	Based on the topological centrality analyses for exemplars in MIN, we considered the C9orf16, COX5B and ACTB to be key genes in the progress of ovarian cancer
27230828	underexpression	Breast Carcinoma	The ACTB, TUBB, EZR, RDX, FN1, VEGFA, FLK1 Casp9, Casp3, PRKCA mRNAs were downregulated in 5d-MCS-samples.
27070589	underexpression	Thyroid Gland Carcinoma	Of the 24 genes analyzed VEGFA, VEGFD, MSN, and MMP3 were upregulated in MCS compared to 1g-controls, whereas ACTB, ACTA2, KRT8, TUBB, EZR, RDX, PRKCA, CAV1, MMP9, PAI1, CTGF, MCP1 were downregulated.
25575809	underexpression (hypermethylation)	Head and Neck Squamous Cell Carcinoma	HNSCC patients with lower ratio of GRIM-19/ACTB hypermethylation had increased overall and disease free survival.
25232253	overexpression	Gastric Adenocarcinoma	Further, comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpress β-actin in tumor tissues, however, significant difference was observed only in inflammatory cells (5.92 ± 0.23 vs 6.71 ± 0.14, P < 0.01).
25192722	overexpression	Malignant Ovarian Neoplasm	A total of 17 expressed differential proteins were identified, 8 proteins were upregulated (ACTB, TIM, PDIA3, PDIA1, DCTN2, KIC17, SIAS, and KIC10) and 9 downregulated (KIC18, GRP78, CAPG, PPIA, ROA2, LMNA, EZRI, ADRM1, and ENOA).
23635433	overexpression	Gastric Carcinoma	The level of β-actin was significantly higher in gastric cancer tissues than in the corresponding normal mucosa.
25083461	underexpression	Breast Carcinoma	The expressions of keratin type I cytoskeletal 19 (KIC19) and thymidine phosphorylase (TYPH) were up-regulated, and the expressions of heat shock protein 27 (HSP27), keratin type I cytoskeletal 9 (KIC9), collagen alpha-2(VI) (CO6A2), vimentin (VIME), and actin cytoplasmic 1 (ACTB) were down-regulated in the drug resistant group.
21125333	overexpression	Esophageal Squamous Cell Carcinoma	Comparison of patterns revealed 20 proteins significantly changed, of which 12 protein with concordantly increased, such as ACTB protein, COMT protein, Syntaxin binding protein Pyruvate Kinase (PKM2), Cathepsin D, Chromosome 1 open reading frame 8, Heat shock protein 27, Cdc42, Proteosome, LLDBP, Immunoglobulin, TNF receptor associated factor 7; and eight protein spots with concordantly decreased intensity in ESCC, such as Adenylate kinase 1, General transcription factor II H, Smooth muscle protein, Trangelin, Early endosome antigen 1, Annexin A2, Fibrin beta, Tropomyosin.
20701774	overexpression	Melanoma	Highly expressed proteins in B16M group included cytoskeleton/structure proteins (vimentin, gamma-actin, beta-actin, laminin binding protein), the chaperone family of proteins (heavy-chain binding protein, Bip), immunoproteasome assembly (proteasome activator REG alpha) and others involved in glycolysis activity (PGK1, enolase, TPI, human skeletal muscle GAPDH) and protein transport (myoglobin).
20683002	overexpression	Gastrointestinal Stromal Tumors	Regarding the primary lesion sites, the following 6 genes were overexpressed in tumors in the stomach: RBL2, RHOA, SHC1, HSP90AB1, ACTB and BAS2C.
20362224	underexpression	Osteosarcoma	The six down-regulated proteins include ADCY1, ATP5B, TUBB, RCN3, ACTB, and YWHAZ.
19535095	overexpression	Hepatocellular Carcinoma	Overexpressed proteins included beta-5-tubulin, beta-actin, vimentin, hypermethylated in cancer 2 protein, heat-shock 70-kDa protein 9B, serum albumin, 39S ribosomal protein L45, butyrophilin, autoimmune regulator, and transcription factor ETV7.
18932288	overexpression	Hepatocellular Carcinoma	The up-regulated genes in HCV-infected group included 4 genes: VIM (cell structure), ACTB (cell structure), GAPD (glycolysis) and CD58 (cell adhesion).
18787018	aberrant expression	Breast Carcinoma	Overexpression of full-length Ago2, but not truncated forms of Ago2 or an empty vector control, reduced the levels of E-cadherin, beta-catenin, and beta-actin, as well as enhanced endogenous miR-206 activity. These data indicate that Ago2 is regulated at both the transcriptional and posttranslational level, and also implicate Ago2 and enhanced micro-RNA activity in the tumorigenic progression of breast cancer cell lines.
15940343	overexpression	Hepatocellular Carcinoma	Statistically significant increase of beta-actin level in highly motile EB3 cells variant should be underlined to compare with the other sublines.
1693276	overexpression	Colon Carcinoma	About 47% and 16% of these tumor samples also showed increased levels of ODC (mean 3.1-fold) and beta-actin (mean 1.6-fold) RNA, respectively.
3380097	underexpression (mutation)	Fibroblastic Neoplasm	HuT-14T is a highly tumorigenic fibroblast cell line which exhibits a reduced steady-state level of beta-actin due to coding mutations in one of two beta-actin alleles.
3374511	underexpression (mutation)	Fibroblastic Neoplasm	The HuT-14 substrain expresses a defective beta-actin as a consequence of a point mutation in 1 of the 2 functional beta-actin alleles.
28498803	altered expression	Glioma; Glioblastoma	A small scale validation study confirmed significant changes in mRNA expression levels of VIM, DPYSL2, ACTB and TRIM28. This work helps to fill the information gap in this field by defining novel differences in biochemical profiles between gliomas and reference samples. Thus, selected genes can be used to distinguish glioblastoma from lower grade gliomas, and from reference samples.

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.178	0.000332	5.4	47.5	47	Gain
BRCA	Breast invasive carcinoma	1075	0.279	1.25e-20	11.3	56.7	32	Neutral
CESC	Cervical and endocervical cancers	292	0.302	1.42e-07	11	74	15.1	Neutral
COAD	Colon adenocarcinoma	449	0.101	0.0326	0.4	43.2	56.3	Gain
ESCA	Esophageal carcinoma	183	0.195	0.0083	4.9	25.1	69.9	Gain
GBM	Glioblastoma multiforme	147	0.097	0.24	1.4	19.7	78.9	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.324	5e-14	4.7	55.3	40.1	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.045	0.304	0.4	66.7	33	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.228	9.33e-05	0.3	39.2	60.4	Gain
LAML	Acute Myeloid Leukemia	166	0.239	0.00192	9.6	89.8	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.258	2.94e-09	2.9	74.9	22.2	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.187	0.000328	4.7	62.6	32.7	Neutral
LUAD	Lung adenocarcinoma	512	0.386	1.24e-19	5.7	39.5	54.9	Gain
LUSC	Lung squamous cell carcinoma	498	0.334	1.96e-14	10.4	37.3	52.2	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.368	4.72e-11	48.3	29.7	22	Loss
PAAD	Pancreatic adenocarcinoma	177	-0.009	0.903	1.7	70.1	28.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.114	0.149	0	82.7	17.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.023	0.614	1.4	78.2	20.4	Neutral
READ	Rectum adenocarcinoma	164	0.2	0.0103	0.6	34.1	65.2	Gain
SARC	Sarcoma	255	0.102	0.103	12.2	52.5	35.3	Gain
SKCM	Skin Cutaneous Melanoma	367	0.133	0.0106	4.6	38.7	56.7	Gain
STAD	Stomach adenocarcinoma	413	0.131	0.00787	4.1	44.3	51.6	Gain
TGCT	Testicular Germ Cell Tumors	150	0.099	0.229	1.3	14.7	84	Gain
THCA	Thyroid carcinoma	497	0.116	0.00944	0	96.4	3.6	Neutral
THYM	Thymoma	119	0.037	0.688	1.7	86.6	11.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.21	9.09e-07	11.5	73.4	15.1	Neutral

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.323	1.26e-11	17	408	-0.113	7.2e-06	NS/NA
BRCA	Breast invasive carcinoma	-0.378	0	83	785	-0.112	1.12e-06	NS/NA
CESC	Cervical and endocervical cancers	-0.235	3.12e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.177	0.00163	19	297	0	0.0318	NS/NA
ESCA	Esophageal carcinoma	-0.23	0.00131	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.502	2.62e-05	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.142	0.000936	20	522	0.003	0.0367	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.239	7.86e-06	24	319	-0.116	1.23e-11	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.255	9.03e-06	23	275	-0.273	8.14e-43	Decreased
LAML	Acute Myeloid Leukemia	-0.135	0.0799	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.216	5.47e-07	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.14	0.00426	41	373	0.005	0.0202	NS/NA
LUAD	Lung adenocarcinoma	-0.115	0.0122	21	456	-0.001	0.212	NS/NA
LUSC	Lung squamous cell carcinoma	-0.332	4.68e-11	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.6	0.0968	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.497	0	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.294	4.86e-05	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.158	0.000265	35	498	0.004	6.63e-09	NS/NA
READ	Rectum adenocarcinoma	-0.324	0.000997	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.453	0	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.214	2.86e-06	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.165	0.0014	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.243	0.00229	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.181	1.63e-05	50	509	-0.076	1.08e-11	NS/NA
THYM	Thymoma	-0.558	0	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.274	2.34e-09	34	431	-0.001	0.424	NS/NA

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	3	High
Bone marrow	2	Medium
Breast	3	High
Bronchus	0	Not detected
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	1	Low
Cervix, uterine	0	Not detected
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	3	High
Esophagus	0	Not detected
Fallopian tube	0	Not detected
Gallbladder	3	High
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	0	Not detected
Lung	1	Low
Lymph node	3	High
Nasopharynx	0	Not detected
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	1	Low
Parathyroid gland	0	Not detected
Placenta	1	Low
Prostate	0	Not detected
Rectum	2	Medium
Salivary gland	1	Low
Seminal vesicle	0	Not detected
Skeletal muscle	2	Medium
Skin	0	Not detected
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	1	Low
Spleen	3	High
Stomach	3	High
Testis	2	Medium
Thyroid gland	0	Not detected
Tonsil	3	High
Urinary bladder	0	Not detected
Vagina	0	Not detected

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.336	NS	24476821
BRCA	Breast invasive carcinoma	521	8.49e-18	Significant	23000897
COAD	Colon adenocarcinoma	149	0.119	NS	22810696
GBM	Glioblastoma multiforme	157	0.000115	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.06e-18	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.064	NS	26536169
LGG	Brain Lower Grade Glioma	513	3.19e-09	Significant	26824661
LUAD	Lung adenocarcinoma	230	8.71e-11	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	2.1e-08	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	3.41e-09	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.152	NS	26544944
READ	Rectum adenocarcinoma	67	0.0269	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0284	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.000364	Significant	25079317
THCA	Thyroid carcinoma	391	0.000294	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	2.24e-06	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.385	0.147	NS
BRCA	Breast invasive carcinoma	1079	1.123	0.595	NS
CESC	Cervical and endocervical cancers	291	1.043	0.9	NS
COAD	Colon adenocarcinoma	439	0.867	0.633	NS
ESCA	Esophageal carcinoma	184	0.856	0.632	NS
GBM	Glioblastoma multiforme	158	1.306	0.275	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.665	0.00852	Shorter
KIRC	Kidney renal clear cell carcinoma	531	2.656	2.63e-05	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.844	0.671	NS
LAML	Acute Myeloid Leukemia	149	1.388	0.277	NS
LGG	Brain Lower Grade Glioma	511	1.315	0.283	NS
LIHC	Liver hepatocellular carcinoma	365	1.085	0.737	NS
LUAD	Lung adenocarcinoma	502	1.654	0.0147	Shorter
LUSC	Lung squamous cell carcinoma	494	1.212	0.319	NS
OV	Ovarian serous cystadenocarcinoma	303	1.07	0.753	NS
PAAD	Pancreatic adenocarcinoma	177	2.006	0.0242	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	0.186	0.103	NS
PRAD	Prostate adenocarcinoma	497	0.499	0.563	NS
READ	Rectum adenocarcinoma	159	5.144	0.00808	Shorter
SARC	Sarcoma	259	0.518	0.021	Longer
SKCM	Skin Cutaneous Melanoma	459	1.203	0.345	NS
STAD	Stomach adenocarcinoma	388	1.241	0.344	NS
TGCT	Testicular Germ Cell Tumors	134	0.798	0.873	NS
THCA	Thyroid carcinoma	500	1.14	0.84	NS
THYM	Thymoma	119	0.329	0.189	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.728	0.28	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.175	0.000387	Higher
BRCA	Breast invasive carcinoma	1071	0.03	0.321	NS
CESC	Cervical and endocervical cancers	167	-0.113	0.145	NS
COAD	Colon adenocarcinoma	445	0.037	0.44	NS
ESCA	Esophageal carcinoma	162	-0.114	0.148	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.073	0.124	NS
KIRC	Kidney renal clear cell carcinoma	531	0.201	3.15e-06	Higher
KIRP	Kidney renal papillary cell carcinoma	260	-0.057	0.357	NS
LIHC	Liver hepatocellular carcinoma	347	0.001	0.989	NS
LUAD	Lung adenocarcinoma	507	0.078	0.0784	NS
LUSC	Lung squamous cell carcinoma	497	-0.009	0.838	NS
OV	Ovarian serous cystadenocarcinoma	302	0.054	0.346	NS
PAAD	Pancreatic adenocarcinoma	176	0.173	0.0215	Higher
READ	Rectum adenocarcinoma	156	0.026	0.751	NS
SKCM	Skin Cutaneous Melanoma	410	0.033	0.506	NS
STAD	Stomach adenocarcinoma	392	0.004	0.933	NS
TGCT	Testicular Germ Cell Tumors	81	0.142	0.205	NS
THCA	Thyroid carcinoma	499	0.091	0.0418	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.022	0.626	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.022	0.716	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.096	0.0317	Lower
KIRC	Kidney renal clear cell carcinoma	525	0.276	1.18e-10	Higher
LGG	Brain Lower Grade Glioma	514	0.169	0.000115	Higher
LIHC	Liver hepatocellular carcinoma	366	0.073	0.162	NS
OV	Ovarian serous cystadenocarcinoma	296	0.003	0.955	NS
PAAD	Pancreatic adenocarcinoma	176	0.095	0.209	NS
STAD	Stomach adenocarcinoma	406	0.12	0.0152	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.005	0.905	NS

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for ACTB.

Summary
Symbol	ACTB
Name	actin beta
Aliases	BRWS1; PS1TP5BP1; PS1TP5-binding protein 1; beta cytoskeletal actin; Beta-actin; Actin, cytoplasmic 1
Location	7p22.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
18787018	Breast Carcinoma	upstream	Ago2	negative regulation	Overexpression of full-length Ago2, but not truncated forms of Ago2 or an empty vector control, reduced the levels of E-cadherin, beta-catenin, and beta-actin, as well as enhanced endogenous miR-206 activity.
15555571	Ito Cell Tumor	partner	GLI	Fusion	Pericytoma with t(7;12) is a newly defined soft tissue tumor characterized by fusion of the ACTB and GLI genes through the translocation t(7;12)(p22;q13).
15111311	Ito Cell Tumor	partner	GLI	Fusion	Pericytoma with t(7;12) is a newly defined soft tissue tumor characterized by fusion of the ACTB and GLI genes through the translocation t(7;12)(p22;q13).