Browse AIRE in pancancer

Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF03172 HSR domain
PF00628 PHD-finger
PF01342 SAND domain
Function

Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity).

Classification
Class Modification Substrate Product PubMed
Histone modification read # H3K4, H3K4me3, DNA motif # 18292755
> Gene Ontology
 
Biological Process GO:0002521 leukocyte differentiation
GO:0006417 regulation of translation
GO:0006959 humoral immune response
GO:0007159 leukocyte cell-cell adhesion
GO:0010608 posttranscriptional regulation of gene expression
GO:0030098 lymphocyte differentiation
GO:0030217 T cell differentiation
GO:0033077 T cell differentiation in thymus
GO:0034248 regulation of cellular amide metabolic process
GO:0042110 T cell activation
GO:0043383 negative T cell selection
GO:0045058 T cell selection
GO:0045060 negative thymic T cell selection
GO:0045061 thymic T cell selection
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
Molecular Function GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0042393 histone binding
GO:0045182 translation regulator activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04120 Ubiquitin mediated proteolysis
Reactome -
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
COSMIC ID CDS change AA change Mutation Type Anatomical Site
COSM2820655c.1466delCp.S491fs*30Deletion - FrameshiftLarge_intestine
COSM3842010c.1613G>Ap.R538HSubstitution - MissenseBreast
COSM5444742c.548C>Ap.T183NSubstitution - MissenseOesophagus
COSM5461498c.1095+6G>Ap.?UnknownLarge_intestine
COSM1031243c.709G>Ap.E237KSubstitution - MissenseLiver
COSM4485063c.288C>Tp.I96ISubstitution - coding silentSkin
COSM4134978c.99T>Cp.A33ASubstitution - coding silentThyroid
COSM1616125c.1633T>Ap.S545TSubstitution - MissenseLiver
COSM3912237c.990C>Tp.I330ISubstitution - coding silentSkin
COSM3551337c.972C>Tp.S324SSubstitution - coding silentSkin
COSM444569c.1197T>Cp.A399ASubstitution - coding silentLarge_intestine
COSM1291188c.1082C>Ap.P361HSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3551337c.972C>Tp.S324SSubstitution - coding silentSkin
COSM3681279c.681C>Ap.G227GSubstitution - coding silentHaematopoietic_and_lymphoid_tissue
COSM1327377c.1191G>Tp.L397LSubstitution - coding silentOvary
COSM5723194c.1038G>Ap.Q346QSubstitution - coding silentSkin
COSM1031243c.709G>Ap.E237KSubstitution - MissenseCervix
COSM5393004c.1554C>Tp.S518SSubstitution - coding silentSkin
COSM1031242c.572C>Tp.A191VSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3551341c.1120G>Ap.G374RSubstitution - MissenseSkin
COSM3708081c.538+6C>Tp.?UnknownLiver
COSM2820607c.680G>Ap.G227DSubstitution - MissenseLarge_intestine
COSM3964002c.874C>Ap.H292NSubstitution - MissenseLung
COSM3405441c.352G>Ap.V118ISubstitution - MissenseCentral_nervous_system
COSM4660678c.937G>Ap.G313SSubstitution - MissenseLarge_intestine
COSM4660677c.424G>Ap.A142TSubstitution - MissenseLarge_intestine
COSM3708081c.538+6C>Tp.?UnknownLiver
COSM329123c.1578T>Cp.D526DSubstitution - coding silentThyroid
COSM5599045c.623G>Ap.G208ESubstitution - MissenseSkin
COSM4880787c.979C>Ap.L327ISubstitution - MissenseProstate
COSM444569c.1197T>Cp.A399ASubstitution - coding silentLarge_intestine
COSM1682027c.230T>Ap.F77YSubstitution - MissenseLarge_intestine
COSM5036989c.1235C>Tp.S412LSubstitution - MissenseOesophagus
COSM4660682c.1330C>Tp.L444LSubstitution - coding silentLarge_intestine
COSM5599045c.623G>Ap.G208ESubstitution - MissenseSkin
COSM1682028c.1546C>Ap.L516MSubstitution - MissenseLarge_intestine
COSM5636717c.612G>Cp.G204GSubstitution - coding silentOesophagus
COSM4987570c.1370G>Ap.C457YSubstitution - MissenseSoft_tissue
COSM3551330c.152A>Tp.E51VSubstitution - MissenseSkin
COSM1031240c.508G>Ap.A170TSubstitution - MissenseEndometrium
COSM5471305c.1503+9C>Tp.?UnknownLarge_intestine
COSM341239c.138G>Tp.T46TSubstitution - coding silentLung
COSM5818372c.778G>Ap.G260RSubstitution - MissenseLiver
COSM1616125c.1633T>Ap.S545TSubstitution - MissenseLiver
COSM3551335c.735G>Ap.K245KSubstitution - coding silentSkin
COSM3912235c.344C>Tp.P115LSubstitution - MissenseSkin
COSM5599045c.623G>Ap.G208ESubstitution - MissenseSkin
COSM2820599c.371C>Tp.P124LSubstitution - MissenseLarge_intestine
COSM419672c.442C>Gp.P148ASubstitution - MissenseUrinary_tract
COSM1031241c.553T>Cp.S185PSubstitution - MissenseEndometrium
COSM1751678c.1147G>Ap.E383KSubstitution - MissenseUrinary_tract
COSM1616123c.1194G>Ap.P398PSubstitution - coding silentLiver
COSM4555651c.663G>Ap.K221KSubstitution - coding silentSkin
COSM137739c.151G>Ap.E51KSubstitution - MissenseSkin
COSM1682027c.230T>Ap.F77YSubstitution - MissenseLarge_intestine
COSM5962168c.790G>Ap.A264TSubstitution - MissenseBreast
COSM5714411c.1369T>Cp.C457RSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM350273c.790G>Tp.A264SSubstitution - MissenseLung
COSM4458777c.1099C>Tp.P367SSubstitution - MissenseSkin
COSM1031242c.572C>Tp.A191VSubstitution - MissenseEndometrium
COSM3912234c.307G>Ap.D103NSubstitution - MissenseSkin
COSM4582114c.328C>Tp.R110WSubstitution - MissenseBone
COSM1616123c.1194G>Ap.P398PSubstitution - coding silentLiver
COSM3758929c.681C>Tp.G227GSubstitution - coding silentLiver
COSM4453713c.337A>Gp.R113GSubstitution - MissenseSkin
COSM350272c.608G>Ap.R203QSubstitution - MissenseSkin
COSM2820627c.891C>Tp.D297DSubstitution - coding silentProstate
COSM4101927c.1367G>Ap.R456HSubstitution - MissenseStomach
COSM1031244c.1115C>Tp.S372LSubstitution - MissenseEndometrium
COSM5600996c.1281C>Tp.N427NSubstitution - coding silentSkin
COSM444569c.1197T>Cp.A399ASubstitution - coding silentThyroid
COSM1682028c.1546C>Ap.L516MSubstitution - MissenseLarge_intestine
COSM1031240c.508G>Ap.A170TSubstitution - MissenseSmall_intestine
COSM1031243c.709G>Ap.E237KSubstitution - MissenseEndometrium
COSM3551343c.1522G>Ap.E508KSubstitution - MissenseSkin
COSM3842010c.1613G>Ap.R538HSubstitution - MissenseBone
COSM725897c.325C>Ap.P109TSubstitution - MissenseLung
COSM350272c.608G>Ap.R203QSubstitution - MissenseLung
COSM2820627c.891C>Tp.D297DSubstitution - coding silentProstate
COSM1031245c.1399G>Ap.G467RSubstitution - MissenseEndometrium
COSM4002050c.588C>Tp.S196SSubstitution - coding silentHaematopoietic_and_lymphoid_tissue
COSM4883916c.808G>Ap.E270KSubstitution - MissenseUpper_aerodigestive_tract
COSM5661260c.538G>Tp.G180WSubstitution - MissenseSoft_tissue
COSM3551336c.852C>Tp.A284ASubstitution - coding silentSkin
COSM5812617c.859A>Tp.S287CSubstitution - MissenseLiver
COSM350272c.608G>Ap.R203QSubstitution - MissenseSkin
COSM109614c.1105G>Ap.G369RSubstitution - MissenseSkin
COSM3551336c.852C>Tp.A284ASubstitution - coding silentSkin
COSM2820655c.1466delCp.S491fs*30Deletion - FrameshiftLarge_intestine
COSM3912236c.838C>Tp.P280SSubstitution - MissenseOesophagus
COSM3551341c.1120G>Ap.G374RSubstitution - MissenseSkin
COSM309012c.657C>Ap.G219GSubstitution - coding silentLung
COSM3693810c.1065C>Tp.P355PSubstitution - coding silentLarge_intestine
COSM3551331c.350C>Tp.A117VSubstitution - MissenseStomach
COSM1751676c.1118C>Tp.A373VSubstitution - MissensePancreas
COSM4101920c.539-1G>Tp.?UnknownStomach
COSM4428241c.1214C>Tp.P405LSubstitution - MissenseOesophagus
COSM2820609c.726G>Ap.G242GSubstitution - coding silentSkin
COSM329123c.1578T>Cp.D526DSubstitution - coding silentKidney
COSM4543227c.333G>Ap.K111KSubstitution - coding silentSkin
COSM4940513c.1066C>Tp.R356WSubstitution - MissenseLiver
COSM4101921c.967C>Ap.L323MSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM4660684c.1383C>Tp.A461ASubstitution - coding silentLarge_intestine
COSM213501c.1531C>Gp.L511VSubstitution - MissenseBreast
COSM1616123c.1194G>Ap.P398PSubstitution - coding silentLiver
COSM4654832c.1171A>Gp.T391ASubstitution - MissenseLarge_intestine
COSM5707568c.47C>Tp.T16MSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM5599045c.623G>Ap.G208ESubstitution - MissenseSkin
COSM2820659c.1563C>Tp.S521SSubstitution - coding silentLarge_intestine
COSM725895c.1278+1G>Tp.?UnknownLung
COSM3912236c.838C>Tp.P280SSubstitution - MissenseSkin
COSM4469929c.1629C>Tp.F543FSubstitution - coding silentSkin
COSM3551331c.350C>Tp.A117VSubstitution - MissenseSkin
COSM4134979c.758A>Cp.K253TSubstitution - MissenseThyroid
COSM329123c.1578T>Cp.D526DSubstitution - coding silentHaematopoietic_and_lymphoid_tissue
COSM5723194c.1038G>Ap.Q346QSubstitution - coding silentSkin
COSM5441684c.511G>Cp.E171QSubstitution - MissenseOesophagus
COSM3551332c.393G>Ap.K131KSubstitution - coding silentSkin
COSM329123c.1578T>Cp.D526DSubstitution - coding silentThyroid
COSM375441c.983G>Tp.R328LSubstitution - MissenseLung
COSM1031239c.272G>Ap.G91DSubstitution - MissenseEndometrium
COSM1751676c.1118C>Tp.A373VSubstitution - MissenseUrinary_tract
COSM1566043c.105C>Tp.H35HSubstitution - coding silentLarge_intestine
COSM4564102c.307_307+1GG>AAp.?UnknownSkin
COSM298045c.294C>Ap.D98ESubstitution - MissenseLarge_intestine
COSM478639c.899C>Tp.A300VSubstitution - MissenseKidney
COSM4829132c.946C>Tp.R316WSubstitution - MissenseCervix
COSM5723194c.1038G>Ap.Q346QSubstitution - coding silentSkin
COSM2820631c.947G>Ap.R316QSubstitution - MissenseLarge_intestine
COSM4837620c.1455G>Tp.E485DSubstitution - MissenseCervix
COSM3551339c.985G>Ap.E329KSubstitution - MissenseSkin
COSM4508870c.78C>Ap.F26LSubstitution - MissenseSkin
COSM4101923c.1301G>Ap.C434YSubstitution - MissenseStomach
COSM725896c.807T>Cp.G269GSubstitution - coding silentLung
COSM3758929c.681C>Tp.G227GSubstitution - coding silentBreast
COSM5690585c.521G>Cp.R174PSubstitution - MissenseSoft_tissue
COSM2152687c.416_418delGAGp.R139_A140>PComplex - deletion inframeCentral_nervous_system
COSM2820661c.1579G>Ap.G527SSubstitution - MissenseLung
COSM3758929c.681C>Tp.G227GSubstitution - coding silentLarge_intestine
COSM4822576c.948G>Tp.R316RSubstitution - coding silentCervix
COSM5558484c.366G>Cp.L122FSubstitution - MissenseProstate
COSM1682027c.230T>Ap.F77YSubstitution - MissenseLarge_intestine
COSM5393003c.106G>Ap.D36NSubstitution - MissenseSkin
COSM5723194c.1038G>Ap.Q346QSubstitution - coding silentSkin
COSM5511332c.977C>Tp.P326LSubstitution - MissenseBiliary_tract
COSM4620116c.278T>Cp.L93PSubstitution - MissenseLarge_intestine
COSM5599045c.623G>Ap.G208ESubstitution - MissenseSkin
COSM5569242c.452C>Ap.T151NSubstitution - MissenseProstate
COSM1031238c.207G>Tp.Q69HSubstitution - MissenseEndometrium
COSM4101925c.1348G>Ap.A450TSubstitution - MissenseStomach
COSM3551333c.409G>Ap.E137KSubstitution - MissenseSkin
COSM5461498c.1095+6G>Ap.?UnknownLarge_intestine
COSM4660680c.1078delCp.P360fs*18Deletion - FrameshiftLarge_intestine
COSM3551334c.613G>Ap.A205TSubstitution - MissenseSkin
COSM6006216c.118G>Ap.E40KSubstitution - MissenseSmall_intestine
COSM1751676c.1118C>Tp.A373VSubstitution - MissenseUrinary_tract
COSM4101921c.967C>Ap.L323MSubstitution - MissenseStomach
COSM4986035c.1528G>Ap.A510TSubstitution - MissenseSoft_tissue
COSM3912236c.838C>Tp.P280SSubstitution - MissenseSkin
COSM3551337c.972C>Tp.S324SSubstitution - coding silentSkin
COSM1751678c.1147G>Ap.E383KSubstitution - MissenseUrinary_tract
COSM4754215c.166C>Ap.P56TSubstitution - MissenseStomach
> Text Mining based Variations
 
There is no record for AIRE.
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
There is no PTM data
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
GBMGlioblastoma multiforme5166-0.624-1.936NANANA
LGGBrain Lower Grade Glioma0530NA-1.975NANANA
READRectum adenocarcinoma10167-3.903-3.560.9330.228NS
STADStomach adenocarcinoma35415-5.14-4.6070.6590.107NS
TGCTTesticular Germ Cell Tumors0156NA2.117NANANA
THYMThymoma21201.773-3.497NANANA
> Cancer Cell Line Encyclopedia (CCLE)
 



Tissue Cell Line Expression Level (Microarray)
Autonomic ganglia CHP126 4.5
Autonomic ganglia CHP212 4.5
Autonomic ganglia IMR32 4.3
Autonomic ganglia KELLY 4.8
Autonomic ganglia KPNRTBM1 4.5
Autonomic ganglia KPNSI9S 5.1
Autonomic ganglia KPNYN 4.9
Autonomic ganglia MHHNB11 5.1
Autonomic ganglia NB1 4.3
Autonomic ganglia NH6 4.7
Autonomic ganglia SHSY5Y 4.2
Autonomic ganglia SIMA 4.3
Autonomic ganglia SKNAS 4.8
Autonomic ganglia SKNBE2 4.8
Autonomic ganglia SKNDZ 4.5
Autonomic ganglia SKNFI 4.7
Autonomic ganglia SKNSH 4.7
Biliary tract HUCCT1 4.7
Biliary tract HUH28 5.1
Biliary tract SNU1079 4.6
Biliary tract SNU1196 4.9
Biliary tract SNU245 4.9
Biliary tract SNU308 4.5
Biliary tract SNU478 4.9
Bone 143B 4.8
Bone A673 4.5
Bone CADOES1 4.5
Bone CAL78 4.5
Bone G292CLONEA141B1 4.6
Bone HOS 4.8
Bone HS706T 4.4
Bone HS737T 4.7
Bone HS819T 5.1
Bone HS821T 4.5
Bone HS822T 4.7
Bone HS863T 4.5
Bone HS870T 4.7
Bone HS888T 4.5
Bone MG63 4.7
Bone MHHES1 4.5
Bone OUMS27 4.8
Bone RDES 4.3
Bone SJSA1 4.6
Bone SKES1 4.6
Bone SKNMC 4.7
Bone SW1353 4.5
Bone T173 5
Bone TC71 4.7
Bone U2OS 4.3
Breast AU565 4.8
Breast BT20 4.7
Breast BT474 4.4
Breast BT483 4.3
Breast BT549 5
Breast CAL120 4.6
Breast CAL148 4.8
Breast CAL51 4.6
Breast CAL851 4.4
Breast CAMA1 4.5
Breast DU4475 5.2
Breast EFM192A 4.7
Breast EFM19 4.4
Breast EVSAT 5
Breast HCC1143 4.5
Breast HCC1187 4.8
Breast HCC1395 5.1
Breast HCC1419 4.5
Breast HCC1428 4.6
Breast HCC1500 4.1
Breast HCC1569 4.7
Breast HCC1599 4.8
Breast HCC1806 4.7
Breast HCC1937 4.6
Breast HCC1954 4.4
Breast HCC202 4.7
Breast HCC2157 4.7
Breast HCC2218 4.7
Breast HCC38 4.4
Breast HCC70 4.6
Breast HDQP1 4.6
Breast HMC18 5
Breast HS274T 4.6
Breast HS281T 4.4
Breast HS343T 4.6
Breast HS578T 4.9
Breast HS606T 4.3
Breast HS739T 4.6
Breast HS742T 4.8
Breast JIMT1 4.5
Breast KPL1 4.8
Breast MCF7 4.4
Breast MDAMB134VI 4.3
Breast MDAMB157 4.7
Breast MDAMB175VII 4.5
Breast MDAMB231 4.7
Breast MDAMB361 4.7
Breast MDAMB415 4.6
Breast MDAMB436 4.5
Breast MDAMB453 4.5
Breast MDAMB468 4.9
Breast SKBR3 4.7
Breast T47D 4.7
Breast UACC812 4.5
Breast UACC893 4.7
Breast YMB1 4.9
Breast ZR751 4.7
Breast ZR7530 4.5
Central nervous system 1321N1 4.7
Central nervous system 42MGBA 4.7
Central nervous system 8MGBA 4.6
Central nervous system A172 4.6
Central nervous system AM38 4.8
Central nervous system BECKER 4.2
Central nervous system CAS1 4.7
Central nervous system CCFSTTG1 4.6
Central nervous system D283MED 4.6
Central nervous system D341MED 5
Central nervous system DAOY 4.4
Central nervous system DBTRG05MG 4.3
Central nervous system DKMG 4.8
Central nervous system GAMG 4.6
Central nervous system GB1 4.7
Central nervous system GI1 5
Central nervous system GMS10 4.6
Central nervous system GOS3 4.7
Central nervous system H4 4.4
Central nervous system HS683 4.5
Central nervous system KALS1 4.5
Central nervous system KG1C 5
Central nervous system KNS42 4.5
Central nervous system KNS60 4.5
Central nervous system KNS81 4.7
Central nervous system KS1 4.2
Central nervous system LN18 4.7
Central nervous system LN229 4.5
Central nervous system M059K 4.5
Central nervous system MOGGCCM 4.4
Central nervous system MOGGUVW 4.7
Central nervous system NMCG1 4.6
Central nervous system ONS76 4.7
Central nervous system SF126 4.8
Central nervous system SF295 4.7
Central nervous system SNB19 4.9
Central nervous system SNU1105 4.5
Central nervous system SNU201 4.4
Central nervous system SNU466 4.9
Central nervous system SNU489 4.2
Central nervous system SNU626 4.6
Central nervous system SNU738 4.9
Central nervous system SW1088 4.7
Central nervous system SW1783 4.5
Central nervous system T98G 4.6
Central nervous system TM31 4.3
Central nervous system U118MG 4.3
Central nervous system U138MG 4.4
Central nervous system U251MG 4.5
Central nervous system U87MG 5.1
Central nervous system YH13 4.3
Central nervous system YKG1 4.7
Endometrium AN3CA 4.8
Endometrium COLO684 4.2
Endometrium EFE184 5
Endometrium EN 4.5
Endometrium ESS1 4.4
Endometrium HEC108 4.9
Endometrium HEC151 4.6
Endometrium HEC1A 4.4
Endometrium HEC1B 4.7
Endometrium HEC251 4.4
Endometrium HEC265 4.5
Endometrium HEC50B 4.9
Endometrium HEC59 4.6
Endometrium HEC6 4.6
Endometrium ISHIKAWAHERAKLIO02ER 4.2
Endometrium JHUEM1 4.6
Endometrium JHUEM2 4.4
Endometrium JHUEM3 4.4
Endometrium KLE 4.7
Endometrium MFE280 4.8
Endometrium MFE296 5.2
Endometrium MFE319 5.1
Endometrium RL952 4.7
Endometrium SNGM 4.5
Endometrium SNU1077 4.6
Endometrium SNU685 4.3
Endometrium TEN 4.5
Haematopoietic and lymphoid 697 4.4
Haematopoietic and lymphoid A3KAW 4.8
Haematopoietic and lymphoid A4FUK 4.9
Haematopoietic and lymphoid ALLSIL 4.5
Haematopoietic and lymphoid AML193 4.6
Haematopoietic and lymphoid AMO1 5
Haematopoietic and lymphoid BCP1 5.2
Haematopoietic and lymphoid BDCM 4.8
Haematopoietic and lymphoid BL41 4.7
Haematopoietic and lymphoid BL70 5.1
Haematopoietic and lymphoid BV173 5.4
Haematopoietic and lymphoid CA46 4.8
Haematopoietic and lymphoid CI1 5.6
Haematopoietic and lymphoid CMK115 4.9
Haematopoietic and lymphoid CMK86 4.8
Haematopoietic and lymphoid CMK 5
Haematopoietic and lymphoid CMLT1 4.5
Haematopoietic and lymphoid COLO775 4.5
Haematopoietic and lymphoid DAUDI 5.2
Haematopoietic and lymphoid DB 5.2
Haematopoietic and lymphoid DEL 4.7
Haematopoietic and lymphoid DND41 4.8
Haematopoietic and lymphoid DOHH2 4.8
Haematopoietic and lymphoid EB1 5.1
Haematopoietic and lymphoid EB2 4.8
Haematopoietic and lymphoid EHEB 4.8
Haematopoietic and lymphoid EJM 5
Haematopoietic and lymphoid EM2 4.7
Haematopoietic and lymphoid EOL1 4.7
Haematopoietic and lymphoid F36P 4.8
Haematopoietic and lymphoid GA10 5.2
Haematopoietic and lymphoid GDM1 4.7
Haematopoietic and lymphoid GRANTA519 4.6
Haematopoietic and lymphoid HDLM2 4.6
Haematopoietic and lymphoid HDMYZ 4.5
Haematopoietic and lymphoid HEL9217 4.4
Haematopoietic and lymphoid HEL 4.5
Haematopoietic and lymphoid HH 5.2
Haematopoietic and lymphoid HL60 4.6
Haematopoietic and lymphoid HPBALL 4.9
Haematopoietic and lymphoid HS604T 4.4
Haematopoietic and lymphoid HS611T 5.1
Haematopoietic and lymphoid HS616T 4.9
Haematopoietic and lymphoid HS751T 4.9
Haematopoietic and lymphoid HT 4.8
Haematopoietic and lymphoid HTK 4.8
Haematopoietic and lymphoid HUNS1 5.3
Haematopoietic and lymphoid HUT102 4.7
Haematopoietic and lymphoid HUT78 5.3
Haematopoietic and lymphoid JEKO1 5.1
Haematopoietic and lymphoid JK1 4.8
Haematopoietic and lymphoid JM1 4.7
Haematopoietic and lymphoid JURKAT 4.3
Haematopoietic and lymphoid JURLMK1 4.8
Haematopoietic and lymphoid JVM2 4.8
Haematopoietic and lymphoid JVM3 4.7
Haematopoietic and lymphoid K562 5
Haematopoietic and lymphoid KARPAS299 4.5
Haematopoietic and lymphoid KARPAS422 4.9
Haematopoietic and lymphoid KARPAS620 4.6
Haematopoietic and lymphoid KASUMI1 5.3
Haematopoietic and lymphoid KASUMI2 4.6
Haematopoietic and lymphoid KASUMI6 4.8
Haematopoietic and lymphoid KCL22 4.6
Haematopoietic and lymphoid KE37 4.5
Haematopoietic and lymphoid KE97 5.2
Haematopoietic and lymphoid KG1 4.8
Haematopoietic and lymphoid KHM1B 5.2
Haematopoietic and lymphoid KIJK 4.8
Haematopoietic and lymphoid KMH2 4.9
Haematopoietic and lymphoid KMM1 4.7
Haematopoietic and lymphoid KMS11 4.6
Haematopoietic and lymphoid KMS12BM 5
Haematopoietic and lymphoid KMS18 4.6
Haematopoietic and lymphoid KMS20 4.7
Haematopoietic and lymphoid KMS21BM 5.2
Haematopoietic and lymphoid KMS26 5.3
Haematopoietic and lymphoid KMS27 5.3
Haematopoietic and lymphoid KMS28BM 5.1
Haematopoietic and lymphoid KMS34 5.1
Haematopoietic and lymphoid KO52 4.8
Haematopoietic and lymphoid KOPN8 4.9
Haematopoietic and lymphoid KU812 4.5
Haematopoietic and lymphoid KYO1 4.8
Haematopoietic and lymphoid L1236 5
Haematopoietic and lymphoid L363 4.7
Haematopoietic and lymphoid L428 4.8
Haematopoietic and lymphoid L540 4.8
Haematopoietic and lymphoid LAMA84 4.7
Haematopoietic and lymphoid LOUCY 4.5
Haematopoietic and lymphoid LP1 4.8
Haematopoietic and lymphoid M07E 4.5
Haematopoietic and lymphoid MC116 5.3
Haematopoietic and lymphoid ME1 5.1
Haematopoietic and lymphoid MEC1 4.6
Haematopoietic and lymphoid MEC2 4.8
Haematopoietic and lymphoid MEG01 4.7
Haematopoietic and lymphoid MHHCALL2 4.6
Haematopoietic and lymphoid MHHCALL3 4.7
Haematopoietic and lymphoid MHHCALL4 4.9
Haematopoietic and lymphoid MINO 4.8
Haematopoietic and lymphoid MJ 5
Haematopoietic and lymphoid MM1S 4.8
Haematopoietic and lymphoid MOLM13 4.7
Haematopoietic and lymphoid MOLM16 4.6
Haematopoietic and lymphoid MOLM6 4.7
Haematopoietic and lymphoid MOLP2 4.7
Haematopoietic and lymphoid MOLP8 4.6
Haematopoietic and lymphoid MOLT13 4.9
Haematopoietic and lymphoid MOLT16 4.8
Haematopoietic and lymphoid MOLT4 5.1
Haematopoietic and lymphoid MONOMAC1 4.7
Haematopoietic and lymphoid MONOMAC6 4.4
Haematopoietic and lymphoid MOTN1 5.1
Haematopoietic and lymphoid MUTZ5 4.8
Haematopoietic and lymphoid MV411 4.7
Haematopoietic and lymphoid NALM19 4.9
Haematopoietic and lymphoid NALM1 5.3
Haematopoietic and lymphoid NALM6 4.5
Haematopoietic and lymphoid NAMALWA 4.7
Haematopoietic and lymphoid NB4 5.2
Haematopoietic and lymphoid NCIH929 5.8
Haematopoietic and lymphoid NCO2 5
Haematopoietic and lymphoid NOMO1 4.7
Haematopoietic and lymphoid NUDHL1 5.1
Haematopoietic and lymphoid NUDUL1 4.9
Haematopoietic and lymphoid OCIAML2 4.9
Haematopoietic and lymphoid OCIAML3 4.7
Haematopoietic and lymphoid OCIAML5 4.8
Haematopoietic and lymphoid OCILY10 4.6
Haematopoietic and lymphoid OCILY19 4.7
Haematopoietic and lymphoid OCILY3 5.1
Haematopoietic and lymphoid OCIM1 4.3
Haematopoietic and lymphoid OPM2 4.7
Haematopoietic and lymphoid P12ICHIKAWA 4.8
Haematopoietic and lymphoid P31FUJ 4.8
Haematopoietic and lymphoid P3HR1 5.2
Haematopoietic and lymphoid PCM6 4.8
Haematopoietic and lymphoid PEER 4.9
Haematopoietic and lymphoid PF382 4.6
Haematopoietic and lymphoid PFEIFFER 4.5
Haematopoietic and lymphoid PL21 4.8
Haematopoietic and lymphoid RAJI 4.9
Haematopoietic and lymphoid RCHACV 4.8
Haematopoietic and lymphoid REC1 5.1
Haematopoietic and lymphoid REH 4.5
Haematopoietic and lymphoid RI1 5.1
Haematopoietic and lymphoid RL 5
Haematopoietic and lymphoid RPMI8226 4.9
Haematopoietic and lymphoid RPMI8402 4.6
Haematopoietic and lymphoid RS411 5
Haematopoietic and lymphoid SEM 5
Haematopoietic and lymphoid SET2 4.9
Haematopoietic and lymphoid SIGM5 4.5
Haematopoietic and lymphoid SKM1 4.8
Haematopoietic and lymphoid SKMM2 4.7
Haematopoietic and lymphoid SR786 4.6
Haematopoietic and lymphoid ST486 4.9
Haematopoietic and lymphoid SUDHL10 4.9
Haematopoietic and lymphoid SUDHL1 5.2
Haematopoietic and lymphoid SUDHL4 5
Haematopoietic and lymphoid SUDHL5 4.8
Haematopoietic and lymphoid SUDHL6 4.7
Haematopoietic and lymphoid SUDHL8 5.2
Haematopoietic and lymphoid SUPB15 5
Haematopoietic and lymphoid SUPHD1 5.1
Haematopoietic and lymphoid SUPM2 4.9
Haematopoietic and lymphoid SUPT11 4.9
Haematopoietic and lymphoid SUPT1 4.9
Haematopoietic and lymphoid TALL1 4.7
Haematopoietic and lymphoid TF1 4.6
Haematopoietic and lymphoid THP1 4.7
Haematopoietic and lymphoid TO175T 4.7
Haematopoietic and lymphoid TOLEDO 4.6
Haematopoietic and lymphoid U266B1 5
Haematopoietic and lymphoid U937 5
Haematopoietic and lymphoid UT7 4.8
Haematopoietic and lymphoid WSUDLCL2 4.8
Kidney 769P 4.7
Kidney 786O 4.9
Kidney A498 4.9
Kidney A704 4.9
Kidney ACHN 4.5
Kidney BFTC909 4.7
Kidney CAKI1 4.9
Kidney CAKI2 4.6
Kidney CAL54 4.3
Kidney KMRC1 4.9
Kidney KMRC20 4.3
Kidney KMRC2 4.8
Kidney KMRC3 4.7
Kidney OSRC2 4.4
Kidney RCC10RGB 4.6
Kidney SNU1272 4.3
Kidney SNU349 4.4
Kidney TUHR10TKB 4.4
Kidney TUHR14TKB 4.2
Kidney TUHR4TKB 4.6
Kidney VMRCRCW 4.8
Kidney VMRCRCZ 5
Large intestine C2BBE1 4.5
Large intestine CCK81 4.9
Large intestine CL11 4.4
Large intestine CL14 4.7
Large intestine CL34 4.4
Large intestine CL40 4.7
Large intestine COLO205 5
Large intestine COLO320 4.6
Large intestine COLO678 4.6
Large intestine CW2 4.6
Large intestine DLD1 4.8
Large intestine GP2D 4.8
Large intestine HCC56 4.7
Large intestine HCT116 4.9
Large intestine HCT15 5.1
Large intestine HS675T 4.8
Large intestine HS698T 4.3
Large intestine HT115 4.5
Large intestine HT29 4.9
Large intestine HT55 4.7
Large intestine KM12 4.8
Large intestine LOVO 4.4
Large intestine LS1034 4.7
Large intestine LS123 4.8
Large intestine LS180 4.7
Large intestine LS411N 4.3
Large intestine LS513 4.9
Large intestine MDST8 4.5
Large intestine NCIH508 4.8
Large intestine NCIH716 4.7
Large intestine NCIH747 4.7
Large intestine OUMS23 4.6
Large intestine RCM1 5.1
Large intestine RKO 4.9
Large intestine SKCO1 4.6
Large intestine SNU1040 4.9
Large intestine SNU1197 4.4
Large intestine SNU175 5.3
Large intestine SNU283 4.8
Large intestine SNU407 4.8
Large intestine SNU503 4.6
Large intestine SNU61 4.7
Large intestine SNU81 4.3
Large intestine SNUC1 5.2
Large intestine SNUC2A 4.4
Large intestine SNUC4 4.5
Large intestine SNUC5 4.3
Large intestine SW1116 4.9
Large intestine SW1417 4.6
Large intestine SW1463 5
Large intestine SW403 4.5
Large intestine SW480 4.9
Large intestine SW48 4.9
Large intestine SW620 4.6
Large intestine SW837 4.8
Large intestine SW948 4.7
Large intestine T84 4.7
Liver ALEXANDERCELLS 4.8
Liver C3A 4.8
Liver HEP3B217 4.9
Liver HEPG2 4.6
Liver HLE 5
Liver HLF 4.9
Liver HUH1 5
Liver HUH6 4.7
Liver HUH7 4.5
Liver JHH1 4.9
Liver JHH2 4.5
Liver JHH4 4.6
Liver JHH5 4.7
Liver JHH6 4.6
Liver JHH7 4.9
Liver LI7 4.2
Liver PLCPRF5 4.7
Liver SKHEP1 4.8
Liver SNU182 4.5
Liver SNU387 4.4
Liver SNU398 4.6
Liver SNU423 4.9
Liver SNU449 4.7
Liver SNU475 4.5
Liver SNU761 4.3
Liver SNU878 5
Liver SNU886 4.5
Lung A549 5
Lung ABC1 4.5
Lung BEN 4.5
Lung CAL12T 5
Lung CALU1 4.7
Lung CALU3 4.9
Lung CALU6 4.7
Lung CHAGOK1 4.8
Lung COLO668 4.6
Lung COLO699 5.1
Lung CORL105 4.5
Lung CORL23 4.8
Lung CORL24 4.2
Lung CORL279 4.3
Lung CORL311 4.8
Lung CORL47 4.7
Lung CORL51 4.4
Lung CORL88 4.3
Lung CORL95 4.4
Lung CPCN 4.9
Lung DMS114 4.7
Lung DMS153 4.5
Lung DMS273 4.5
Lung DMS454 5
Lung DMS53 4.6
Lung DMS79 4.6
Lung DV90 4.7
Lung EBC1 4.7
Lung EPLC272H 4.7
Lung HARA 4.9
Lung HCC1171 4.1
Lung HCC1195 5.1
Lung HCC15 4.6
Lung HCC2279 4.5
Lung HCC2935 4.4
Lung HCC33 4.9
Lung HCC366 4.4
Lung HCC4006 4.6
Lung HCC44 4.8
Lung HCC78 4.6
Lung HCC827 4.5
Lung HCC95 4.6
Lung HLC1 4.6
Lung HLFA 4.3
Lung HS229T 4.8
Lung HS618T 4.7
Lung IALM 4.9
Lung KNS62 5.5
Lung LC1F 4.6
Lung LC1SQSF 4.7
Lung LCLC103H 4.1
Lung LCLC97TM1 4.6
Lung LK2 4.6
Lung LOUNH91 5.1
Lung LU65 4.7
Lung LU99 5
Lung LUDLU1 4.4
Lung LXF289 4.4
Lung MORCPR 4.8
Lung NCIH1048 4.6
Lung NCIH1092 4.4
Lung NCIH1105 4.3
Lung NCIH1155 4.4
Lung NCIH1184 4.7
Lung NCIH1299 4.9
Lung NCIH1339 4.5
Lung NCIH1341 4.6
Lung NCIH1355 4.3
Lung NCIH1373 4.7
Lung NCIH1385 4.3
Lung NCIH1395 5.3
Lung NCIH1435 4.6
Lung NCIH1436 4.4
Lung NCIH1437 4.6
Lung NCIH146 4.3
Lung NCIH1563 4.6
Lung NCIH1568 4.8
Lung NCIH1573 4.8
Lung NCIH1581 4.5
Lung NCIH1618 4.3
Lung NCIH1623 5
Lung NCIH1648 4.5
Lung NCIH1650 4.6
Lung NCIH1651 4.7
Lung NCIH1666 4.8
Lung NCIH1693 4.4
Lung NCIH1694 4.5
Lung NCIH1703 4.7
Lung NCIH1734 4.4
Lung NCIH1755 4.4
Lung NCIH1781 4.6
Lung NCIH1792 4.6
Lung NCIH1793 4.4
Lung NCIH1836 4.8
Lung NCIH1838 5.1
Lung NCIH1869 4.5
Lung NCIH1876 4.3
Lung NCIH1915 4.9
Lung NCIH1930 4.6
Lung NCIH1944 4.5
Lung NCIH1963 4.8
Lung NCIH196 5
Lung NCIH1975 4.5
Lung NCIH2009 4.9
Lung NCIH2023 4.8
Lung NCIH2029 4.2
Lung NCIH2030 4.6
Lung NCIH2066 4.4
Lung NCIH2081 4.3
Lung NCIH2085 4.2
Lung NCIH2087 5.2
Lung NCIH209 4.5
Lung NCIH2106 4.7
Lung NCIH2110 4.9
Lung NCIH211 5
Lung NCIH2122 4.6
Lung NCIH2126 4.7
Lung NCIH2141 4.4
Lung NCIH2170 4.6
Lung NCIH2171 4.9
Lung NCIH2172 4.6
Lung NCIH2196 4.4
Lung NCIH2227 4.4
Lung NCIH2228 4.7
Lung NCIH226 4.6
Lung NCIH2286 4.5
Lung NCIH2291 5
Lung NCIH2342 5
Lung NCIH2347 4.9
Lung NCIH23 4.9
Lung NCIH2405 4.4
Lung NCIH2444 4.8
Lung NCIH292 4.7
Lung NCIH322 4.9
Lung NCIH3255 4.5
Lung NCIH358 4.5
Lung NCIH441 4.5
Lung NCIH446 4.8
Lung NCIH460 5.1
Lung NCIH510 4.5
Lung NCIH520 4.8
Lung NCIH522 4.5
Lung NCIH524 4.7
Lung NCIH526 4.4
Lung NCIH596 4.7
Lung NCIH647 4.6
Lung NCIH650 4.6
Lung NCIH661 4.4
Lung NCIH69 4.4
Lung NCIH727 4.3
Lung NCIH810 5
Lung NCIH82 4.7
Lung NCIH838 4.4
Lung NCIH841 4.4
Lung NCIH854 4.7
Lung NCIH889 4.9
Lung PC14 5
Lung RERFLCAD1 4.7
Lung RERFLCAD2 4.5
Lung RERFLCAI 4.5
Lung RERFLCKJ 4.6
Lung RERFLCMS 4.9
Lung RERFLCSQ1 4.4
Lung SBC5 4.8
Lung SCLC21H 4.5
Lung SHP77 4.4
Lung SKLU1 4.3
Lung SKMES1 4.8
Lung SQ1 4.9
Lung SW1271 4.5
Lung SW1573 4.4
Lung SW900 4.7
Lung VMRCLCD 4.6
Lung VMRCLCP 4.6
Oesophagus COLO680N 4.6
Oesophagus ECGI10 4.3
Oesophagus KYSE140 4.7
Oesophagus KYSE150 4.7
Oesophagus KYSE180 5
Oesophagus KYSE270 4.5
Oesophagus KYSE30 4.6
Oesophagus KYSE410 5
Oesophagus KYSE450 5
Oesophagus KYSE510 4.6
Oesophagus KYSE520 4.9
Oesophagus KYSE70 4.7
Oesophagus OE19 4.8
Oesophagus OE33 4.7
Oesophagus TE10 5.1
Oesophagus TE11 4.4
Oesophagus TE14 4.2
Oesophagus TE15 4.7
Oesophagus TE1 4.6
Oesophagus TE4 4.3
Oesophagus TE5 4.5
Oesophagus TE6 4.6
Oesophagus TE8 4
Oesophagus TE9 4.6
Oesophagus TT 4.8
Ovary 59M 4.5
Ovary A2780 4.7
Ovary CAOV3 4.8
Ovary CAOV4 4.5
Ovary COLO704 4.5
Ovary COV318 4.8
Ovary COV362 4.7
Ovary COV434 4.8
Ovary COV504 4.3
Ovary COV644 4.5
Ovary EFO21 4.4
Ovary EFO27 4.7
Ovary ES2 4.9
Ovary FUOV1 4.7
Ovary HEYA8 4.8
Ovary HS571T 4.7
Ovary IGROV1 4.9
Ovary JHOC5 4.4
Ovary JHOM1 4.3
Ovary JHOM2B 4.3
Ovary JHOS2 4.6
Ovary JHOS4 4.8
Ovary KURAMOCHI 4.7
Ovary MCAS 4.9
Ovary NIHOVCAR3 4.3
Ovary OAW28 4.8
Ovary OAW42 4.3
Ovary OC314 4.7
Ovary OC316 4.7
Ovary ONCODG1 4.5
Ovary OV56 4.8
Ovary OV7 4.5
Ovary OV90 4.5
Ovary OVCAR4 4.5
Ovary OVCAR8 4.8
Ovary OVISE 4.6
Ovary OVK18 4.5
Ovary OVKATE 4.4
Ovary OVMANA 4.9
Ovary OVSAHO 5
Ovary OVTOKO 5.2
Ovary RMGI 5.1
Ovary RMUGS 5.1
Ovary SKOV3 4.8
Ovary SNU119 4.2
Ovary SNU840 4.9
Ovary SNU8 4.5
Ovary TOV112D 4.5
Ovary TOV21G 4.6
Ovary TYKNU 4.8
Pancreas ASPC1 4.6
Pancreas BXPC3 4.5
Pancreas CAPAN1 4.6
Pancreas CAPAN2 4.7
Pancreas CFPAC1 4.7
Pancreas DANG 4.7
Pancreas HPAC 4.3
Pancreas HPAFII 4.7
Pancreas HS766T 4.5
Pancreas HUPT3 4.8
Pancreas HUPT4 4.9
Pancreas KCIMOH1 4.6
Pancreas KLM1 4.4
Pancreas KP2 4.4
Pancreas KP3 4.7
Pancreas KP4 4.4
Pancreas L33 4.7
Pancreas MIAPACA2 4.6
Pancreas PANC0203 4.5
Pancreas PANC0213 4.5
Pancreas PANC0327 4.7
Pancreas PANC0403 4.7
Pancreas PANC0504 4.7
Pancreas PANC0813 5.1
Pancreas PANC1005 4.7
Pancreas PANC1 4.7
Pancreas PATU8902 4.6
Pancreas PATU8988S 4.6
Pancreas PATU8988T 4.6
Pancreas PK1 5.1
Pancreas PK45H 4.7
Pancreas PK59 4.6
Pancreas PL45 4.7
Pancreas PSN1 4.8
Pancreas QGP1 4.7
Pancreas SNU213 4.3
Pancreas SNU324 4.4
Pancreas SNU410 4.5
Pancreas SU8686 4.5
Pancreas SUIT2 4.7
Pancreas SW1990 4.8
Pancreas T3M4 5
Pancreas TCCPAN2 4.4
Pancreas YAPC 4.5
Pleura ACCMESO1 4.5
Pleura DM3 4.8
Pleura ISTMES1 4.5
Pleura ISTMES2 5
Pleura JL1 4.7
Pleura MPP89 4.8
Pleura MSTO211H 4.7
Pleura NCIH2052 4.5
Pleura NCIH2452 4.8
Pleura NCIH28 4.9
Prostate 22RV1 4.7
Prostate DU145 4.4
Prostate LNCAPCLONEFGC 4.6
Prostate MDAPCA2B 4.9
Prostate NCIH660 4.5
Prostate PC3 4.6
Prostate VCAP 4.7
Salivary gland A253 4.7
Salivary gland YD15 4.5
Skin A101D 4.9
Skin A2058 4.3
Skin A375 4.4
Skin C32 4.8
Skin CHL1 4.4
Skin CJM 4.3
Skin COLO679 4.9
Skin COLO741 4.6
Skin COLO783 4.6
Skin COLO792 4.8
Skin COLO800 4.6
Skin COLO818 4.9
Skin COLO829 4.5
Skin COLO849 4.8
Skin G361 4.4
Skin GRM 4.4
Skin HMCB 4.7
Skin HS294T 4.8
Skin HS600T 4.6
Skin HS688AT 4.7
Skin HS695T 4.6
Skin HS839T 4.7
Skin HS852T 4.3
Skin HS895T 4.5
Skin HS934T 4.7
Skin HS936T 4.7
Skin HS939T 4.9
Skin HS940T 4.4
Skin HS944T 4.6
Skin HT144 4.6
Skin IGR1 4.4
Skin IGR37 4.7
Skin IGR39 4.4
Skin IPC298 4.7
Skin K029AX 4.6
Skin LOXIMVI 4.6
Skin MALME3M 4.5
Skin MDAMB435S 4.6
Skin MELHO 4.4
Skin MELJUSO 4.7
Skin MEWO 4.9
Skin RPMI7951 4.2
Skin RVH421 5
Skin SH4 4.7
Skin SKMEL1 4.6
Skin SKMEL24 4.9
Skin SKMEL28 4.6
Skin SKMEL2 4.6
Skin SKMEL30 4.7
Skin SKMEL31 4.7
Skin SKMEL3 4.5
Skin SKMEL5 4.7
Skin UACC257 4.4
Skin UACC62 5.1
Skin WM115 4.6
Skin WM1799 4.5
Skin WM2664 4.4
Skin WM793 4.6
Skin WM88 4.5
Skin WM983B 4.7
Small intestine HUTU80 4.9
Soft tissue A204 5
Soft tissue G401 4.8
Soft tissue G402 5.1
Soft tissue GCT 4.6
Soft tissue HS729 4.5
Soft tissue HT1080 5
Soft tissue KYM1 4.8
Soft tissue MESSA 4.7
Soft tissue RD 4.8
Soft tissue RH30 4.5
Soft tissue RH41 4.5
Soft tissue RKN 4.7
Soft tissue S117 4.7
Soft tissue SJRH30 4.9
Soft tissue SKLMS1 4.7
Soft tissue SKUT1 5
Soft tissue TE125T 4.6
Soft tissue TE159T 4.5
Soft tissue TE441T 4.8
Soft tissue TE617T 4.6
Stomach 2313287 4.4
Stomach AGS 4.9
Stomach AZ521 4.6
Stomach ECC10 4.2
Stomach ECC12 4.3
Stomach FU97 5
Stomach GCIY 4.7
Stomach GSS 4.5
Stomach GSU 4.5
Stomach HGC27 4.9
Stomach HS746T 4.5
Stomach HUG1N 4.8
Stomach IM95 4.5
Stomach KATOIII 4.8
Stomach KE39 4.8
Stomach LMSU 4.4
Stomach MKN1 4.4
Stomach MKN45 4.6
Stomach MKN74 4.7
Stomach MKN7 4.4
Stomach NCCSTCK140 4.6
Stomach NCIN87 4.7
Stomach NUGC2 4.9
Stomach NUGC3 4.7
Stomach NUGC4 5.1
Stomach OCUM1 4.7
Stomach RERFGC1B 4.8
Stomach SH10TC 4.3
Stomach SNU16 5.2
Stomach SNU1 5
Stomach SNU216 4.6
Stomach SNU520 4.5
Stomach SNU5 4.7
Stomach SNU601 4.5
Stomach SNU620 4.4
Stomach SNU668 5
Stomach SNU719 4.4
Stomach TGBC11TKB 4.6
Thyroid 8305C 4.6
Thyroid 8505C 4.9
Thyroid BCPAP 4.2
Thyroid BHT101 4.6
Thyroid CAL62 4.4
Thyroid CGTHW1 4.6
Thyroid FTC133 4.6
Thyroid FTC238 4.6
Thyroid ML1 4.3
Thyroid SW579 4.8
Thyroid TT2609C02 4.4
Thyroid TT 4.5
Upper aerodigestive tract BHY 4.5
Upper aerodigestive tract BICR16 4.9
Upper aerodigestive tract BICR18 4.6
Upper aerodigestive tract BICR22 4.9
Upper aerodigestive tract BICR31 4.7
Upper aerodigestive tract BICR56 4.9
Upper aerodigestive tract BICR6 4.6
Upper aerodigestive tract CAL27 4.6
Upper aerodigestive tract CAL33 4.4
Upper aerodigestive tract DETROIT562 4.7
Upper aerodigestive tract FADU 4.9
Upper aerodigestive tract HS840T 4.7
Upper aerodigestive tract HSC2 4.9
Upper aerodigestive tract HSC3 4.8
Upper aerodigestive tract HSC4 4.6
Upper aerodigestive tract PECAPJ15 4.3
Upper aerodigestive tract PECAPJ34CLONEC12 4.6
Upper aerodigestive tract PECAPJ41CLONED2 4.6
Upper aerodigestive tract PECAPJ49 4.5
Upper aerodigestive tract SCC15 4.5
Upper aerodigestive tract SCC25 5.1
Upper aerodigestive tract SCC4 4.6
Upper aerodigestive tract SCC9 4.3
Upper aerodigestive tract SNU1076 4.9
Upper aerodigestive tract SNU1214 4.6
Upper aerodigestive tract SNU46 4.3
Upper aerodigestive tract SNU899 4.2
Upper aerodigestive tract YD10B 4.5
Upper aerodigestive tract YD38 4.7
Upper aerodigestive tract YD8 4.5
Urinary tract 5637 4.7
Urinary tract 639V 4.7
Urinary tract 647V 4.7
Urinary tract BC3C 4.3
Urinary tract BFTC905 4.7
Urinary tract CAL29 4.8
Urinary tract HS172T 4.6
Urinary tract HT1197 4.7
Urinary tract HT1376 4.9
Urinary tract J82 5.2
Urinary tract JMSU1 4.4
Urinary tract KMBC2 5.1
Urinary tract KU1919 4.4
Urinary tract RT11284 4.5
Urinary tract RT112 4.8
Urinary tract RT4 5
Urinary tract SCABER 4.8
Urinary tract SW1710 4.6
Urinary tract SW780 4.7
Urinary tract T24 4.7
Urinary tract TCCSUP 4.7
Urinary tract UMUC1 5
Urinary tract UMUC3 5.3
Urinary tract VMCUB1 4.5
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 0
Adrenal gland 0
Appendix 0.1
Bone marrow 0
Breast 0.1
Cerebral cortex 0.2
Cervix, uterine 0
Colon 0
Duodenum 0
Endometrium 0
Epididymis 0.1
Esophagus 0
Fallopian tube 0
Gallbladder 0
Heart muscle 0
Kidney 0
Liver 0
Lung 0
Lymph node 0.3
Ovary 0
Pancreas 0
Parathyroid gland 0
Placenta 0
Prostate 0
Rectum 0
Salivary gland 0
Seminal vesicle 0.1
Skeletal muscle 0
Skin 0
Small intestine 0.1
Smooth muscle 0
Spleen 0
Stomach 0
Testis 0
Thyroid gland 0
Tonsil 0
Urinary bladder 0
> Text Mining based Expression
 
PMID Expression Cancer Evidence
25396311loss of expressionThymomaHowever, several abnormalities have been described in thymomas that may affect normal T-cell development: the tumor architecture is distorted, neoplastics expresses less MHC class II, most thymomas do not express AIRE, and production of T-regulator cells is decreased.
18568643underexpressionThymomaOnly 23/45 (51.1%) of thymomas expressed AIRE mRNA at low levels while all normal thymi expressed AIRE mRNA.
16806159underexpressionProstate CarcinomaCyclopentenone prostaglandins (PGs) such as PGA1, PGA2 and delta12-PGJ2 have been shown to suppress tumor cell growth and to induce apoptosis in prostate cancer cells.
27753538altered expression Breast CarcinomaBoth in the RNA-seq and gene expression datasets analyzed, AIRE expression was an independent strong prognostic factor for relapse-free survival (RFS), particularly in estrogen receptor-positive tumors. Enrichment of translation-related pathways was observed in AIRE-expressing tumors by Ingenuity Pathway Analysis and a significant increase of cells in G1 phase and activation of caspase cascades was induced by AIRE transfection in breast cancer luminal cell lines, suggesting that AIRE-induced over-translation of proteins lead to cycle arrest and apoptosis. These data are the first to identify AIRE expression in breast cancer and an association with prognosis.
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
Cancer Full Name # Sample R P % Loss % Neutral % Gain Status
GBMGlioblastoma multiforme1470.0260.7526.876.916.3Neutral
LGGBrain Lower Grade Glioma5130.0350.4277.887.34.9Neutral
READRectum adenocarcinoma164-0.0660.442.151.26.7Loss
STADStomach adenocarcinoma4130.0890.071443.850.85.3Loss
TGCTTesticular Germ Cell Tumors150-0.0440.595213.384.7Gain
THYMThymoma119-0.0170.8538.489.91.7Neutral
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
GBMGlioblastoma multiforme-0.2380.056164NANANS/NA
LGGBrain Lower Grade Glioma-0.2013.13e-060530NANANS/NA
READRectum adenocarcinoma-0.2730.00596299NANANS/NA
STADStomach adenocarcinoma-0.2575.67e-070372NANANS/NA
TGCTTesticular Germ Cell Tumors-0.60200156NANANS/NA
THYMThymoma-0.2540.004892120NANANS/NA
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Level Level Name
Adrenal gland 0 Not detected
Appendix 2 Medium
Bone marrow 3 High
Breast 2 Medium
Bronchus 2 Medium
Caudate 1 Low
Cerebellum 1 Low
Cerebral cortex 1 Low
Cervix, uterine 2 Medium
Colon 3 High
Duodenum 3 High
Endometrium 3 High
Epididymis 2 Medium
Esophagus 1 Low
Fallopian tube 2 Medium
Gallbladder 3 High
Heart muscle 0 Not detected
Hippocampus 2 Medium
Kidney 3 High
Liver 2 Medium
Lung 1 Low
Lymph node 1 Low
Nasopharynx 2 Medium
Oral mucosa 1 Low
Ovary 1 Low
Pancreas 3 High
Parathyroid gland 0 Not detected
Placenta 2 Medium
Prostate 2 Medium
Rectum 2 Medium
Salivary gland 2 Medium
Seminal vesicle 2 Medium
Skeletal muscle 0 Not detected
Skin 1 Low
Small intestine 3 High
Smooth muscle 0 Not detected
Soft tissue 2 Medium
Spleen 2 Medium
Stomach 3 High
Testis 1 Low
Thyroid gland 2 Medium
Tonsil 1 Low
Urinary bladder 3 High
Vagina 0 Not detected
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
GBMGlioblastoma multiforme1570.223NS26824661
LGGBrain Lower Grade Glioma5130.393NS26824661
READRectum adenocarcinoma670.209NS22810696
STADStomach adenocarcinoma2770.000161Significant25079317
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
GBMGlioblastoma multiforme158 1.4110.191NS
LGGBrain Lower Grade Glioma511 1.3260.244NS
READRectum adenocarcinoma159 1.5560.382NS
STADStomach adenocarcinoma388 1.6490.0265Shorter
TGCTTesticular Germ Cell Tumors134 1.5770.71NS
THYMThymoma119 0.3640.362NS
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
READRectum adenocarcinoma156 0.0870.278NS
STADStomach adenocarcinoma392 0.0310.538NS
TGCTTesticular Germ Cell Tumors81 0.1460.193NS
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
LGGBrain Lower Grade Glioma514 -0.0560.204NS
STADStomach adenocarcinoma406 -0.0320.52NS
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for AIRE.
Summary
SymbolAIRE
Nameautoimmune regulator
Aliases PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; APECED; autoimmune regulator (autoimmu ......
Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
There is no record for AIRE.
> Interactions from Text Mining
 
There is no record for AIRE.