Browse AKAP1 in pancancer

Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF00013 KH domain
PF00567 Tudor domain
Function

Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.

Classification
Class Modification Substrate Product PubMed
# # # # #
> Gene Ontology
 
Biological Process GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0010737 protein kinase A signaling
GO:0010738 regulation of protein kinase A signaling
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
Molecular Function GO:0034237 protein kinase A regulatory subunit binding
GO:0051018 protein kinase A binding
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0019867 outer membrane
GO:0031968 organelle outer membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-109582: Hemostasis
Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
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COSMIC ID
CDS change
AA change
Mutation Type
Anatomical Site
COSM253161c.946G>Ap.G316SSubstitution - MissenseBreast
COSM4802624c.1616G>Ap.S539NSubstitution - MissenseLiver
COSM4603858c.963delGp.E322fs*30Deletion - FrameshiftUpper_aerodigestive_tract
COSM5818245c.536A>Gp.Q179RSubstitution - MissenseLiver
COSM1742735c.2193T>Gp.P731PSubstitution - coding silentBiliary_tract
COSM3519942c.2148C>Tp.N716NSubstitution - coding silentSkin
COSM2153202c.2068T>Ap.S690TSubstitution - MissenseCentral_nervous_system
COSM3378263c.2453C>Tp.P818LSubstitution - MissensePancreas
COSM3519927c.548C>Tp.P183LSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM5642752c.497A>Gp.K166RSubstitution - MissenseOesophagus
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> Text Mining based Variations
 
There is no record for AKAP1.
Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
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Uniprot ID
Position
Amino Acid
Description
Upstream Enzyme
Amino Acid Sequence Variant
Q92667105SPhosphoserine-None detected
Q92667107SPhosphoserine-None detected
Q92667151SPhosphoserine-None detected
Q92667169SPhosphoserine-None detected
Q92667429SPhosphoserine-None detected
Q92667445SPhosphoserine-None detected
Q92667447TPhosphothreonine-None detected
Q92667533TPhosphothreonine-None detected
Q92667573SPhosphoserine-None detected
Q92667590TPhosphothreonine-None detected
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Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
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Cancer
Full Name
# N
# T
Median (N)
Median (T)
LogFC
Adj. P
Status
BLCABladder urothelial carcinoma194086.5616.264-0.3420.0524NS
BRCABreast invasive carcinoma11211007.0216.479-0.5461.51e-13NS
CESCCervical and endocervical cancers33065.9836.062NANANA
COADColon adenocarcinoma414597.797.776-0.0070.941NS
ESCAEsophageal carcinoma111857.2356.446-0.5470.09NS
GBMGlioblastoma multiforme51666.2965.561NANANA
HNSCHead and Neck squamous cell carcinoma445226.1715.623-0.6566.46e-10Under
KIRCKidney renal clear cell carcinoma725346.3965.815-0.5291.68e-18NS
KIRPKidney renal papillary cell carcinoma322916.5516.7070.1520.157NS
LAMLAcute Myeloid Leukemia0173NA5.625NANANA
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> Cancer Cell Line Encyclopedia (CCLE)
 



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Tissue
Cell Line
Expression Level (Microarray)
Autonomic gangliaCHP1269.8
Autonomic gangliaCHP2129.8
Autonomic gangliaIMR3210.1
Autonomic gangliaKELLY10
Autonomic gangliaKPNRTBM19.7
Autonomic gangliaKPNSI9S8.6
Autonomic gangliaKPNYN9.2
Autonomic gangliaMHHNB1110
Autonomic gangliaNB19.7
Autonomic gangliaNH69.6
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> The Human Protein Atlas (HPA)
 


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Tissue
Expression Level (TPM)
Adipose tissue43.1
Adrenal gland15.1
Appendix22.7
Bone marrow4.1
Breast33.4
Cerebral cortex32.5
Cervix, uterine19.1
Colon65.6
Duodenum53.2
Endometrium34.1
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> Text Mining based Expression
 
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PMID
Expression
Cancer
Evidence
28569781OverexpressionGlioblastoma; Lung Carcinoma High levels of AKAP1 were found in a wide variety of high-grade cancer tissues. In lung cancer, AKAP1 expression correlates with high levels of Myc, mTOR phosphorylation and reduced patient survival.
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Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
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Cancer
Full Name
# Sample
R
P
% Loss
% Neutral
% Gain
Status
BLCABladder urothelial carcinoma4040.5397.71e-327.249.543.3Gain
BRCABreast invasive carcinoma10750.5562.89e-8817.747.335Gain
CESCCervical and endocervical cancers2920.4131.96e-139.669.520.9Neutral
COADColon adenocarcinoma4490.514.39e-3113.165.721.2Neutral
ESCAEsophageal carcinoma1830.3624.72e-0711.557.930.6Neutral
GBMGlioblastoma multiforme1470.3665.04e-068.279.612.2Neutral
HNSCHead and Neck squamous cell carcinoma5140.4532.3e-277.673.319.1Neutral
KIRCKidney renal clear cell carcinoma5250.10.02225.3886.7Neutral
KIRPKidney renal papillary cell carcinoma2880.5512.96e-240.330.968.8Gain
LAMLAcute Myeloid Leukemia1660.2510.00109394.62.4Neutral
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Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
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Cancer
Full Name
R
P
# N
# T
Delta beta (T vs N)
P value (T vs N)
Status
BLCABladder urothelial carcinoma-0.463017408-0.0341.04e-15NS/NA
BRCABreast invasive carcinoma-0.2886.91e-1883785-0.0010.449NS/NA
CESCCervical and endocervical cancers-0.2431.66e-053306NANANS/NA
COADColon adenocarcinoma-0.497019297-0.0870.00497NS/NA
ESCAEsophageal carcinoma-0.60409185NANANS/NA
GBMGlioblastoma multiforme-0.4260.000447164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.1964.64e-06205220.0010.00928NS/NA
KIRCKidney renal clear cell carcinoma-0.2982.13e-0824319-0.0450.0359NS/NA
KIRPKidney renal papillary cell carcinoma-0.546023275-0.0940.000322NS/NA
LAMLAcute Myeloid Leukemia-0.3153.09e-050170NANANS/NA
Showing 1 to 10 of 26 rows rows per page
Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


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Tissue
Level
Level Name
Adrenal gland2Medium
Appendix3High
Bone marrow2Medium
Breast3High
Bronchus2Medium
Caudate3High
Cerebellum3High
Cerebral cortex3High
Cervix, uterine3High
Colon3High
Showing 1 to 10 of 44 rows rows per page
Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
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Cancer
Full Name
# Patients
P Value (Kruskal-Wallis)
Association
Source
BLCABladder urothelial carcinoma1280.352NS24476821
BRCABreast invasive carcinoma5213.37e-07Significant23000897
COADColon adenocarcinoma1491.51e-06Significant22810696
GBMGlioblastoma multiforme1579.09e-05Significant26824661
HNSCHead and Neck squamous cell carcinoma2794.75e-19Significant25631445
KIRPKidney renal papillary cell carcinoma1610.013Significant26536169
LGGBrain Lower Grade Glioma5132.24e-21Significant26824661
LUADLung adenocarcinoma2302.02e-07Significant25079552
LUSCLung squamous cell carcinoma1781.26e-11Significant22960745
OVOvarian serous cystadenocarcinoma2870.0032Significant21720365
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> Overall survival
 

  Overall survival analysis based on expression.
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Cancer
Full Name
# Patients
Hazard Ratio
P Value (Log Rank Test)
Association
BLCABladder urothelial carcinoma405 0.9980.994NS
BRCABreast invasive carcinoma1079 1.1880.449NS
CESCCervical and endocervical cancers291 1.1880.598NS
COADColon adenocarcinoma439 0.5420.0257Longer
ESCAEsophageal carcinoma184 0.9030.774NS
GBMGlioblastoma multiforme158 0.7580.28NS
HNSCHead and Neck squamous cell carcinoma518 1.0670.747NS
KIRCKidney renal clear cell carcinoma531 0.4640.000339Longer
KIRPKidney renal papillary cell carcinoma287 0.5480.195NS
LAMLAcute Myeloid Leukemia149 1.4120.225NS
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> Stage
 

  Association between expresson and stage.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
BLCABladder urothelial carcinoma406 -0.0460.36NS
BRCABreast invasive carcinoma1071 0.0390.2NS
CESCCervical and endocervical cancers167 -0.0020.978NS
COADColon adenocarcinoma445 0.0140.768NS
ESCAEsophageal carcinoma162 -0.0560.477NS
HNSCHead and Neck squamous cell carcinoma448 0.1350.00419Higher
KIRCKidney renal clear cell carcinoma531 -0.1928.08e-06Lower
KIRPKidney renal papillary cell carcinoma260 -0.1170.0587NS
LIHCLiver hepatocellular carcinoma347 0.0210.7NS
LUADLung adenocarcinoma507 -0.0780.08NS
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> Grade
 

  Association between expresson and grade.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
CESCCervical and endocervical cancers272 0.0060.921NS
HNSCHead and Neck squamous cell carcinoma498 0.2063.39e-06Higher
KIRCKidney renal clear cell carcinoma525 -0.140.00131Lower
LGGBrain Lower Grade Glioma514 -0.1550.000408Lower
LIHCLiver hepatocellular carcinoma366 -0.0640.222NS
OVOvarian serous cystadenocarcinoma296 -0.0640.274NS
PAADPancreatic adenocarcinoma176 -0.0220.774NS
STADStomach adenocarcinoma406 -0.2141.41e-05Lower
UCECUterine Corpus Endometrial Carcinoma534 -0.0940.029Lower
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Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for AKAP1.
Summary
SymbolAKAP1
NameA-kinase anchoring protein 1
Aliases AKAP121; AKAP149; SAKAP84; S-AKAP84; AKAP84; D-AKAP1; PPP1R43; TDRD17; protein kinase anchoring protein 1; d ......
Location17q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
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PMID
Cancer
Hierarchy
Gene
Relation to CR
Evidence
28569781Glioblastoma; Lung CarcinomapartnerMyc; mTOR phosphorylationPositive correlationIn lung cancer, AKAP1 expression correlates with high levels of Myc, mTOR phosphorylation and reduced patient survival.
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