CR2Cancer

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF01388 ARID/BRIGHT DNA binding domain
PF12031 SWI/SNF-like complex subunit BAF250/Osa

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone ubiquitination	H2BK120, DNA motif	#	20086098

> Gene Ontology [ TOP ]
Biological Process	GO:0006338 chromatin remodeling GO:0040029 regulation of gene expression, epigenetic GO:0045815 positive regulation of gene expression, epigenetic GO:0048096 chromatin-mediated maintenance of transcription
Molecular Function	GO:0003713 transcription coactivator activity
Cellular Component	GO:0016514 SWI/SNF complex GO:0070603 SWI/SNF superfamily-type complex GO:0071565 nBAF complex GO:0090544 BAF-type complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214858: RMTs methylate histone arginines

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM159176	c.3390C>G	p.Y1130*	Substitution - Nonsense	Breast
COSM351346	c.5377G>T	p.E1793*	Substitution - Nonsense	Lung
COSM3410731	c.2786C>T	p.A929V	Substitution - Missense	Large_intestine
COSM4767421	c.5368C>T	p.R1790C	Substitution - Missense	Large_intestine
COSM1496260	c.4114G>A	p.D1372N	Substitution - Missense	Kidney
COSM3622271	c.2480G>A	p.R827Q	Substitution - Missense	Skin
COSM4797025	c.2400G>A	p.G800G	Substitution - coding silent	Liver
COSM5547110	c.2476_2483delGGACGAAT	p.G826fs*42	Deletion - Frameshift	Prostate
COSM3920984	c.5902C>T	p.P1968S	Substitution - Missense	Skin
COSM5607872	c.5817C>T	p.F1939F	Substitution - coding silent	Skin
COSM5034727	c.6130G>A	p.E2044K	Substitution - Missense	Oesophagus
COSM5607874	c.5656C>T	p.P1886S	Substitution - Missense	Skin
COSM5495288	c.3476A>G	p.K1159R	Substitution - Missense	Biliary_tract
COSM4635348	c.6653C>T	p.A2218V	Substitution - Missense	Large_intestine
COSM5949853	c.1200_1218del19	p.G403fs*35	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3374118	c.5167G>A	p.D1723N	Substitution - Missense	Thyroid
COSM450799	c.5137G>C	p.E1713Q	Substitution - Missense	Breast
COSM3730478	c.1641G>A	p.P547P	Substitution - coding silent	Stomach
COSM5752821	c.1982_1983insG	p.S665fs*27	Insertion - Frameshift	Breast
COSM5752708	c.3109G>T	p.E1037*	Substitution - Nonsense	Breast
COSM3860000	c.5750C>T	p.A1917V	Substitution - Missense	Stomach
COSM5492163	c.1023delG	p.G343fs*29	Deletion - Frameshift	Biliary_tract
COSM165983	c.5409_5444del36	p.G1804_H1815del12	Deletion - In frame	Breast
COSM5474900	c.1583A>T	p.Q528L	Substitution - Missense	Large_intestine
COSM4646767	c.672C>G	p.P224P	Substitution - coding silent	Large_intestine
COSM3022243	c.1551C>T	p.Y517Y	Substitution - coding silent	Large_intestine
COSM3859982	c.4303C>T	p.Q1435*	Substitution - Nonsense	Stomach
COSM4945411	c.2171G>T	p.G724V	Substitution - Missense	Liver
COSM4663238	c.787_789delGGA	p.G270delG	Deletion - In frame	Large_intestine
COSM116080	c.5672A>C	p.Q1891P	Substitution - Missense	Ovary
COSM5814345	c.4231A>T	p.R1411W	Substitution - Missense	Liver
COSM740283	c.4193G>T	p.R1398L	Substitution - Missense	Lung
COSM1075358	c.5178C>T	p.D1726D	Substitution - coding silent	Endometrium
COSM1183553	c.803G>C	p.G268A	Substitution - Missense	Large_intestine
COSM309267	c.3285G>T	p.L1095F	Substitution - Missense	Lung
COSM5702544	c.3291+1G>A	p.?	Unknown	Central_nervous_system
COSM5131843	c.4505A>G	p.Q1502R	Substitution - Missense	Small_intestine
COSM4767418	c.2449A>C	p.S817R	Substitution - Missense	Biliary_tract
COSM3737745	c.6181C>A	p.Q2061K	Substitution - Missense	Soft_tissue
COSM1740874	c.5688delG	p.N1897fs*59	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1075346	c.2889A>C	p.E963D	Substitution - Missense	Endometrium
COSM3715358	c.3202C>G	p.P1068A	Substitution - Missense	Upper_aerodigestive_tract
COSM3697628	c.195G>A	p.Q65Q	Substitution - coding silent	Large_intestine
COSM343090	c.2013T>C	p.S671S	Substitution - coding silent	Lung
COSM4767586	c.189A>G	p.Q63Q	Substitution - coding silent	Biliary_tract
COSM1075352	c.4078G>A	p.G1360S	Substitution - Missense	Endometrium
COSM3622289	c.4632C>T	p.S1544S	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3022498	c.6449C>T	p.T2150M	Substitution - Missense	Large_intestine
COSM3715358	c.3202C>G	p.P1068A	Substitution - Missense	Upper_aerodigestive_tract
COSM4455019	c.6365A>G	p.Q2122R	Substitution - Missense	Skin
COSM1621132	c.1062G>T	p.P354P	Substitution - coding silent	Liver
COSM1716951	c.5181delG	p.E1728fs*20	Deletion - Frameshift	Ovary
COSM5521073	c.5540C>A	p.S1847Y	Substitution - Missense	Biliary_tract
COSM3410731	c.2786C>T	p.A929V	Substitution - Missense	Central_nervous_system
COSM5996707	c.5480G>A	p.R1827H	Substitution - Missense	Prostate
COSM1621132	c.1062G>T	p.P354P	Substitution - coding silent	Liver
COSM3727930	c.4891_4892insG	p.A1631fs*2	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM5105952	c.189_190insCAGCAG	p.Q73_H74insQQ	Insertion - In frame	Large_intestine
COSM3622263	c.1730G>T	p.G577V	Substitution - Missense	Skin
COSM3622283	c.4068C>T	p.R1356R	Substitution - coding silent	Skin
COSM740276	c.5264A>C	p.D1755A	Substitution - Missense	Lung
COSM5105952	c.189_190insCAGCAG	p.Q73_H74insQQ	Insertion - In frame	Upper_aerodigestive_tract
COSM3859996	c.5420A>G	p.D1807G	Substitution - Missense	Stomach
COSM5472196	c.1847A>G	p.D616G	Substitution - Missense	Large_intestine
COSM5019600	c.3960-7A>G	p.?	Unknown	Soft_tissue
COSM420998	c.4162C>G	p.Q1388E	Substitution - Missense	Urinary_tract
COSM4643068	c.5412C>T	p.G1804G	Substitution - coding silent	Large_intestine
COSM1075357	c.5166C>T	p.D1722D	Substitution - coding silent	Endometrium
COSM3022303	c.2465C>T	p.A822V	Substitution - Missense	Large_intestine
COSM4767586	c.189A>G	p.Q63Q	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM2155417	c.1668G>A	p.A556A	Substitution - coding silent	Central_nervous_system
COSM4663250	c.3654G>A	p.V1218V	Substitution - coding silent	Large_intestine
COSM1183549	c.5822C>T	p.P1941L	Substitution - Missense	Large_intestine
COSM398306	c.5089G>T	p.A1697S	Substitution - Missense	Lung
COSM4586403	c.2192T>C	p.M731T	Substitution - Missense	Bone
COSM3928192	c.2902C>T	p.Q968*	Substitution - Nonsense	Central_nervous_system
COSM4817227	c.2002C>T	p.P668S	Substitution - Missense	Cervix
COSM5019600	c.3960-7A>G	p.?	Unknown	Soft_tissue
COSM5996701	c.2763G>A	p.T921T	Substitution - coding silent	Prostate
COSM1075361	c.5577C>T	p.I1859I	Substitution - coding silent	Endometrium
COSM3941605	c.5358C>T	p.D1786D	Substitution - coding silent	Oesophagus
COSM218863	c.3281G>A	p.G1094D	Substitution - Missense	Pancreas
COSM5037017	c.6646C>T	p.L2216L	Substitution - coding silent	Oesophagus
COSM740285	c.3190G>A	p.E1064K	Substitution - Missense	Lung
COSM3381500	c.5006T>G	p.F1669C	Substitution - Missense	Pancreas
COSM3729940	c.5413delG	p.G1806fs*27	Deletion - Frameshift	Stomach
COSM3994702	c.5271G>A	p.K1757K	Substitution - coding silent	Kidney
COSM3697630	c.5473C>T	p.R1825C	Substitution - Missense	Large_intestine
COSM1642928	c.3169C>T	p.R1057*	Substitution - Nonsense	Skin
COSM4646134	c.5096G>T	p.R1699M	Substitution - Missense	Large_intestine
COSM4930812	c.6295A>T	p.R2099W	Substitution - Missense	Liver
COSM5019600	c.3960-7A>G	p.?	Unknown	Soft_tissue
COSM341440	c.1659A>G	p.P553P	Substitution - coding silent	Lung
COSM4170081	c.190_192delCAG	p.Q73delQ	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM3022243	c.1551C>T	p.Y517Y	Substitution - coding silent	Large_intestine
COSM5623685	c.786C>A	p.S262R	Substitution - Missense	Oesophagus
COSM3859968	c.1958C>T	p.A653V	Substitution - Missense	Stomach
COSM5686192	c.4002C>T	p.P1334P	Substitution - coding silent	Soft_tissue
COSM3920986	c.6496C>T	p.P2166S	Substitution - Missense	Skin
COSM3674602	c.2095G>T	p.G699W	Substitution - Missense	Prostate
COSM3622273	c.2679C>A	p.F893L	Substitution - Missense	Skin
COSM3781610	c.768C>A	p.G256G	Substitution - coding silent	Large_intestine
COSM301705	c.5587_5588delCT	p.S1864fs*8	Deletion - Frameshift	Central_nervous_system
COSM5061583	c.3955C>T	p.R1319*	Substitution - Nonsense	Stomach
COSM4915091	c.3261C>G	p.V1087V	Substitution - coding silent	Liver
COSM3783954	c.6354G>A	p.S2118S	Substitution - coding silent	Prostate
COSM4969524	c.1177_1178insCCG	p.S393_Q394insA	Insertion - In frame	Central_nervous_system
COSM740277	c.5260G>A	p.A1754T	Substitution - Missense	Lung
COSM4663252	c.3754A>G	p.M1252V	Substitution - Missense	Large_intestine
COSM4006183	c.4683G>A	p.K1561K	Substitution - coding silent	Urinary_tract
COSM1236669	c.3959+4A>G	p.?	Unknown	Autonomic_ganglia
COSM4170079	c.165_166insCAGCAG	p.Q73_H74insQQ	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM216002	c.5914C>T	p.R1972*	Substitution - Nonsense	Central_nervous_system
COSM3622275	c.2691C>T	p.N897N	Substitution - coding silent	Skin
COSM1075365	c.6114G>T	p.M2038I	Substitution - Missense	Endometrium
COSM4911636	c.4343C>A	p.A1448E	Substitution - Missense	Liver
COSM3829518	c.3106G>A	p.G1036R	Substitution - Missense	Breast
COSM4006185	c.5316G>A	p.K1772K	Substitution - coding silent	Urinary_tract
COSM3366361	c.3345C>G	p.T1115T	Substitution - coding silent	Kidney
COSM1672938	c.4816C>T	p.R1606*	Substitution - Nonsense	Large_intestine
COSM5966713	c.1021_1046del26	p.A341fs*127	Deletion - Frameshift	Adrenal_gland
COSM4767423	c.5356G>C	p.D1786H	Substitution - Missense	Biliary_tract
COSM3727928	c.3857G>A	p.S1286N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4613674	c.1640_1641insGCA	p.Q548_P549insQ	Insertion - In frame	Large_intestine
COSM112022	c.5667_5668insT	p.Q1890fs*36	Insertion - Frameshift	Ovary
COSM1075344	c.198G>A	p.Q66Q	Substitution - coding silent	Endometrium
COSM740284	c.3797G>T	p.G1266V	Substitution - Missense	Lung
COSM5772523	c.4874T>G	p.L1625R	Substitution - Missense	Breast
COSM483608	c.2408T>A	p.M803K	Substitution - Missense	Kidney
COSM1672938	c.4816C>T	p.R1606*	Substitution - Nonsense	Large_intestine
COSM1075359	c.5298C>T	p.F1766F	Substitution - coding silent	Skin
COSM3622305	c.6592C>T	p.L2198F	Substitution - Missense	Skin
COSM223135	c.4051C>T	p.Q1351*	Substitution - Nonsense	Skin
COSM740275	c.5347G>C	p.D1783H	Substitution - Missense	Lung
COSM3381498	c.4674G>A	p.P1558P	Substitution - coding silent	Pancreas
COSM174860	c.6328C>T	p.R2110*	Substitution - Nonsense	Oesophagus
COSM5230002	c.6279delC	p.Y2094fs*4	Deletion - Frameshift	Breast
COSM4663244	c.1889G>T	p.S630I	Substitution - Missense	Large_intestine
COSM3948315	c.2627C>T	p.A876V	Substitution - Missense	Lung
COSM1441824	c.4429C>T	p.R1477C	Substitution - Missense	Large_intestine
COSM309266	c.2493T>A	p.A831A	Substitution - coding silent	Lung
COSM5996929	c.6042C>G	p.S2014S	Substitution - coding silent	Prostate
COSM32748	c.2267G>C	p.G756A	Substitution - Missense	Breast
COSM1187199	c.3658G>C	p.D1220H	Substitution - Missense	Lung
COSM3829518	c.3106G>A	p.G1036R	Substitution - Missense	Breast
COSM1672938	c.4816C>T	p.R1606*	Substitution - Nonsense	Large_intestine
COSM4935861	c.125T>A	p.L42H	Substitution - Missense	Liver
COSM3393942	c.3347C>A	p.S1116*	Substitution - Nonsense	Pancreas
COSM1672938	c.4816C>T	p.R1606*	Substitution - Nonsense	Large_intestine
COSM4917618	c.3149A>G	p.E1050G	Substitution - Missense	Liver
COSM1567957	c.5872G>A	p.G1958R	Substitution - Missense	Large_intestine
COSM5756809	c.4192C>T	p.R1398C	Substitution - Missense	Large_intestine
COSM3381372	c.4412C>T	p.P1471L	Substitution - Missense	Pancreas
COSM1075355	c.4672C>T	p.P1558S	Substitution - Missense	Endometrium
COSM450798	c.4601G>A	p.R1534K	Substitution - Missense	Breast
COSM3948313	c.2042G>A	p.G681D	Substitution - Missense	Lung
COSM3022258	c.1772C>G	p.P591R	Substitution - Missense	Large_intestine
COSM3022375	c.4263G>A	p.Q1421Q	Substitution - coding silent	Large_intestine
COSM5017418	c.1778A>G	p.H593R	Substitution - Missense	Soft_tissue
COSM3622285	c.4147C>T	p.Q1383*	Substitution - Nonsense	Skin
COSM165982	c.5632delC	p.Q1879fs*77	Deletion - Frameshift	Breast
COSM450801	c.6232G>T	p.V2078L	Substitution - Missense	Breast
COSM4793138	c.3285G>A	p.L1095L	Substitution - coding silent	Liver
COSM3859984	c.4393G>T	p.G1465C	Substitution - Missense	Stomach
COSM450796	c.2739C>G	p.N913K	Substitution - Missense	Breast
COSM4956465	c.5776C>T	p.R1926*	Substitution - Nonsense	Liver
COSM309266	c.2493T>A	p.A831A	Substitution - coding silent	Soft_tissue
COSM1075364	c.6049C>T	p.L2017L	Substitution - coding silent	Endometrium
COSM5357611	c.4859G>A	p.R1620H	Substitution - Missense	Large_intestine
COSM3829522	c.4572G>A	p.T1524T	Substitution - coding silent	Breast
COSM3859998	c.5717G>T	p.R1906M	Substitution - Missense	Stomach
COSM1567959	c.3712C>T	p.P1238S	Substitution - Missense	Large_intestine
COSM383477	c.6196G>T	p.E2066*	Substitution - Nonsense	Lung
COSM4663258	c.5488delC	p.L1832fs*1	Deletion - Frameshift	Large_intestine
COSM1716951	c.5181delG	p.E1728fs*20	Deletion - Frameshift	Ovary
COSM1075345	c.1980delC	p.P661fs*13	Deletion - Frameshift	Endometrium
COSM3622269	c.2348C>T	p.S783F	Substitution - Missense	Skin
COSM1441808	c.1520G>A	p.R507Q	Substitution - Missense	Large_intestine
COSM740281	c.4353T>C	p.N1451N	Substitution - coding silent	Lung
COSM351347	c.6505C>T	p.L2169L	Substitution - coding silent	Lung
COSM5404708	c.3934C>T	p.P1312S	Substitution - Missense	Skin
COSM1621134	c.3277G>A	p.G1093R	Substitution - Missense	Liver
COSM4767586	c.189A>G	p.Q63Q	Substitution - coding silent	Large_intestine
COSM5975873	c.787_792delGGAGGA	p.G269_G270delGG	Deletion - In frame	Upper_aerodigestive_tract
COSM1441834	c.5920C>T	p.P1974S	Substitution - Missense	Large_intestine
COSM4160319	c.4536G>T	p.Q1512H	Substitution - Missense	Thyroid
COSM5607860	c.4410C>T	p.P1470P	Substitution - coding silent	Skin
COSM4387252	c.1528G>C	p.G510R	Substitution - Missense	Lung
COSM4406882	c.4578G>A	p.P1526P	Substitution - coding silent	Soft_tissue
COSM4802669	c.6584C>A	p.S2195*	Substitution - Nonsense	Liver
COSM4767421	c.5368C>T	p.R1790C	Substitution - Missense	Biliary_tract
COSM4394220	c.1950C>T	p.S650S	Substitution - coding silent	Skin
COSM421000	c.3209C>T	p.S1070L	Substitution - Missense	Urinary_tract
COSM5422318	c.3375G>A	p.K1125K	Substitution - coding silent	Prostate
COSM1075347	c.3359C>T	p.A1120V	Substitution - Missense	Endometrium
COSM1731935	c.744_745insGGC	p.G261_S262insG	Insertion - In frame	Thyroid
COSM3410733	c.2880C>T	p.D960D	Substitution - coding silent	Central_nervous_system
COSM159176	c.3390C>G	p.Y1130*	Substitution - Nonsense	Breast
COSM5508619	c.6027G>T	p.T2009T	Substitution - coding silent	Biliary_tract
COSM5421688	c.2264C>T	p.A755V	Substitution - Missense	Prostate
COSM3622301	c.6310C>T	p.R2104C	Substitution - Missense	Skin
COSM450795	c.2187delT	p.Q730fs*44	Deletion - Frameshift	Breast
COSM1187195	c.1606C>T	p.Q536*	Substitution - Nonsense	Lung
COSM1716951	c.5181delG	p.E1728fs*20	Deletion - Frameshift	Ovary
COSM5607874	c.5656C>T	p.P1886S	Substitution - Missense	Skin
COSM5623681	c.780A>C	p.G260G	Substitution - coding silent	Oesophagus
COSM5996701	c.2763G>A	p.T921T	Substitution - coding silent	Prostate
COSM405140	c.769_789del21	p.G257_G263delGGGGGSG	Deletion - In frame	Lung
COSM3859986	c.4408C>G	p.P1470A	Substitution - Missense	Stomach
COSM4433126	c.1436C>G	p.S479C	Substitution - Missense	Oesophagus
COSM5580269	c.6353C>T	p.S2118L	Substitution - Missense	Skin
COSM3859992	c.4858C>T	p.R1620C	Substitution - Missense	Stomach
COSM3859966	c.1807A>G	p.R603G	Substitution - Missense	Stomach
COSM5014659	c.5858T>A	p.L1953Q	Substitution - Missense	Kidney
COSM159174	c.2535G>A	p.M845I	Substitution - Missense	Breast
COSM3022504	c.6608G>T	p.R2203L	Substitution - Missense	Large_intestine
COSM3622281	c.3851C>T	p.P1284L	Substitution - Missense	Skin
COSM3022391	c.4406C>T	p.A1469V	Substitution - Missense	Large_intestine
COSM1183565	c.5118G>T	p.L1706F	Substitution - Missense	Large_intestine
COSM1075360	c.5410G>A	p.G1804S	Substitution - Missense	Endometrium
COSM3829524	c.5962G>T	p.A1988S	Substitution - Missense	Breast
COSM5495286	c.304G>A	p.G102R	Substitution - Missense	Biliary_tract
COSM1183559	c.1528G>A	p.G510R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1621138	c.3504G>A	p.S1168S	Substitution - coding silent	Liver
COSM1075362	c.5634C>T	p.P1878P	Substitution - coding silent	Endometrium
COSM3381498	c.4674G>A	p.P1558P	Substitution - coding silent	Pancreas
COSM309267	c.3285G>T	p.L1095F	Substitution - Missense	Soft_tissue
COSM4171525	c.5758C>T	p.Q1920*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4763083	c.1512C>G	p.I504M	Substitution - Missense	Stomach
COSM1731937	c.165_166insCAG	p.Q73_H74insQ	Insertion - In frame	Upper_aerodigestive_tract
COSM4797025	c.2400G>A	p.G800G	Substitution - coding silent	Liver
COSM3413922	c.5535C>T	p.G1845G	Substitution - coding silent	Oesophagus
COSM3374114	c.4144C>T	p.Q1382*	Substitution - Nonsense	Thyroid
COSM3022327	c.2843C>T	p.P948L	Substitution - Missense	Bone
COSM5607846	c.3551C>T	p.S1184F	Substitution - Missense	Skin
COSM4927968	c.1727A>G	p.E576G	Substitution - Missense	Liver
COSM740280	c.4686G>T	p.M1562I	Substitution - Missense	Lung
COSM3781610	c.768C>A	p.G256G	Substitution - coding silent	Kidney
COSM1731933	c.840_841insGTGGCG	p.A282_A283insVA	Insertion - In frame	Central_nervous_system
COSM5641558	c.1155C>T	p.P385P	Substitution - coding silent	Oesophagus
COSM3727066	c.2705T>C	p.M902T	Substitution - Missense	Skin
COSM1165428	c.3873G>A	p.M1291I	Substitution - Missense	Large_intestine
COSM5996703	c.3456G>A	p.G1152G	Substitution - coding silent	Prostate
COSM5975879	c.5483C>T	p.P1828L	Substitution - Missense	Upper_aerodigestive_tract
COSM3860004	c.6600C>T	p.H2200H	Substitution - coding silent	Stomach
COSM5429487	c.2136G>T	p.Q712H	Substitution - Missense	Oesophagus
COSM4425067	c.5169C>T	p.D1723D	Substitution - coding silent	Oesophagus
COSM4160321	c.5418T>G	p.G1806G	Substitution - coding silent	Thyroid
COSM4956465	c.5776C>T	p.R1926*	Substitution - Nonsense	Liver
COSM4602419	c.5226G>C	p.K1742N	Substitution - Missense	Upper_aerodigestive_tract
COSM5602844	c.5868C>T	p.I1956I	Substitution - coding silent	Skin
COSM309265	c.3679G>T	p.D1227Y	Substitution - Missense	Soft_tissue
COSM1731937	c.165_166insCAG	p.Q73_H74insQ	Insertion - In frame	Large_intestine
COSM4586405	c.3165C>T	p.V1055V	Substitution - coding silent	Bone
COSM5404710	c.5667C>T	p.I1889I	Substitution - coding silent	Skin
COSM1075367	c.6621C>A	p.I2207I	Substitution - coding silent	Endometrium
COSM5720825	c.2861C>T	p.P954L	Substitution - Missense	Skin
COSM218863	c.3281G>A	p.G1094D	Substitution - Missense	Pancreas
COSM1075342	c.75_76insCAC	p.H31_A32insH	Insertion - In frame	Endometrium
COSM5962197	c.1100C>A	p.S367*	Substitution - Nonsense	Breast
COSM1075363	c.5982G>A	p.W1994*	Substitution - Nonsense	Endometrium
COSM4969524	c.1177_1178insCCG	p.S393_Q394insA	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM1194909	c.2812G>T	p.A938S	Substitution - Missense	Lung
COSM4663264	c.6574G>A	p.E2192K	Substitution - Missense	Large_intestine
COSM3860006	c.6608G>A	p.R2203Q	Substitution - Missense	Stomach
COSM450802	c.6566G>A	p.R2189K	Substitution - Missense	Breast
COSM1311750	c.1814C>G	p.S605*	Substitution - Nonsense	Urinary_tract
COSM5607868	c.6432C>T	p.F2144F	Substitution - coding silent	Skin
COSM4406882	c.4578G>A	p.P1526P	Substitution - coding silent	Liver
COSM3781610	c.768C>A	p.G256G	Substitution - coding silent	Oesophagus
COSM5781483	c.5938G>C	p.E1980Q	Substitution - Missense	Breast
COSM3859994	c.5016C>A	p.C1672*	Substitution - Nonsense	Stomach
COSM5646460	c.996C>G	p.L332L	Substitution - coding silent	Oesophagus
COSM1183555	c.1640C>T	p.P547L	Substitution - Missense	Large_intestine
COSM420999	c.3928C>T	p.Q1310*	Substitution - Nonsense	Urinary_tract
COSM5019255	c.1504A>G	p.I502V	Substitution - Missense	Soft_tissue
COSM1075349	c.3836C>T	p.T1279M	Substitution - Missense	Prostate
COSM4912860	c.4273A>G	p.I1425V	Substitution - Missense	Liver
COSM5563223	c.192G>A	p.Q64Q	Substitution - coding silent	Prostate
COSM3859964	c.1591G>A	p.V531M	Substitution - Missense	Stomach
COSM5019600	c.3960-7A>G	p.?	Unknown	Soft_tissue
COSM3622303	c.6463C>T	p.Q2155*	Substitution - Nonsense	Skin
COSM5720825	c.2861C>T	p.P954L	Substitution - Missense	Skin
COSM5979284	c.1612G>A	p.G538S	Substitution - Missense	Upper_aerodigestive_tract
COSM5014657	c.2729A>T	p.Q910L	Substitution - Missense	Kidney
COSM1634601	c.2191A>G	p.M731V	Substitution - Missense	Liver
COSM4160317	c.4386C>T	p.G1462G	Substitution - coding silent	Thyroid
COSM1131994	c.4643G>A	p.R1548H	Substitution - Missense	Prostate
COSM3622297	c.5735C>T	p.P1912L	Substitution - Missense	Skin
COSM5105952	c.189_190insCAGCAG	p.Q73_H74insQQ	Insertion - In frame	Large_intestine
COSM4663236	c.745_747delGGC	p.G261delG	Deletion - In frame	Large_intestine
COSM301704	c.2181A>G	p.R727R	Substitution - coding silent	Central_nervous_system
COSM165982	c.5632delC	p.Q1879fs*77	Deletion - Frameshift	Breast
COSM3928190	c.2202T>A	p.Y734*	Substitution - Nonsense	Central_nervous_system
COSM4445381	c.2979C>T	p.V993V	Substitution - coding silent	Skin
COSM396179	c.3455_3456GG>CT	p.G1152>?	Complex	Lung
COSM5607858	c.2014C>T	p.P672S	Substitution - Missense	Skin
COSM4839904	c.3984T>G	p.Y1328*	Substitution - Nonsense	Cervix
COSM4480254	c.2188C>G	p.Q730E	Substitution - Missense	Skin
COSM3781610	c.768C>A	p.G256G	Substitution - coding silent	Pancreas
COSM1658810	c.4390delG	p.G1464fs*12	Deletion - Frameshift	Salivary_gland
COSM5996705	c.4698G>A	p.M1566I	Substitution - Missense	Prostate
COSM4794534	c.4253G>A	p.G1418E	Substitution - Missense	Liver
COSM5607856	c.3488C>T	p.P1163L	Substitution - Missense	Skin
COSM4799236	c.8C>T	p.T3M	Substitution - Missense	Liver
COSM4663260	c.6035A>T	p.N2012I	Substitution - Missense	Large_intestine
COSM3859972	c.2772G>A	p.P924P	Substitution - coding silent	Stomach
COSM1441822	c.4181C>T	p.S1394L	Substitution - Missense	Large_intestine
COSM5020366	c.4470T>C	p.H1490H	Substitution - coding silent	Soft_tissue
COSM1642928	c.3169C>T	p.R1057*	Substitution - Nonsense	Skin
COSM4799236	c.8C>T	p.T3M	Substitution - Missense	Liver
COSM5607866	c.1868delC	p.A623fs*3	Deletion - Frameshift	Skin
COSM1441830	c.5619C>T	p.D1873D	Substitution - coding silent	Large_intestine
COSM1441828	c.5413G>T	p.G1805W	Substitution - Missense	Large_intestine
COSM1621140	c.6211C>G	p.L2071V	Substitution - Missense	Liver
COSM3859968	c.1958C>T	p.A653V	Substitution - Missense	Skin
COSM5996703	c.3456G>A	p.G1152G	Substitution - coding silent	Prostate
COSM4631072	c.6344C>T	p.A2115V	Substitution - Missense	Large_intestine
COSM4767586	c.189A>G	p.Q63Q	Substitution - coding silent	Large_intestine
COSM218863	c.3281G>A	p.G1094D	Substitution - Missense	Pancreas
COSM216001	c.5896G>A	p.E1966K	Substitution - Missense	Central_nervous_system
COSM309265	c.3679G>T	p.D1227Y	Substitution - Missense	Lung
COSM5601048	c.3761G>A	p.R1254K	Substitution - Missense	Skin
COSM5061585	c.4243C>T	p.Q1415*	Substitution - Nonsense	Stomach
COSM1075349	c.3836C>T	p.T1279M	Substitution - Missense	Endometrium
COSM3859978	c.3794G>T	p.G1265V	Substitution - Missense	Stomach
COSM483611	c.6293T>G	p.V2098G	Substitution - Missense	Kidney
COSM3720867	c.4517C>T	p.S1506L	Substitution - Missense	Upper_aerodigestive_tract
COSM5506220	c.6496delC	p.P2167fs*8	Deletion - Frameshift	Biliary_tract
COSM3381496	c.2286G>C	p.Q762H	Substitution - Missense	Pancreas
COSM3022266	c.1954C>A	p.H652N	Substitution - Missense	Large_intestine
COSM4663236	c.745_747delGGC	p.G261delG	Deletion - In frame	Kidney
COSM1698223	c.64C>G	p.P22A	Substitution - Missense	Skin
COSM1187197	c.1996C>T	p.P666S	Substitution - Missense	Lung
COSM3829516	c.3103A>G	p.T1035A	Substitution - Missense	Breast
COSM5810337	c.5578G>T	p.D1860Y	Substitution - Missense	Liver
COSM5550661	c.2361G>A	p.A787A	Substitution - coding silent	Prostate
COSM3381498	c.4674G>A	p.P1558P	Substitution - coding silent	Pancreas
COSM3022256	c.1760delC	p.G589fs*8	Deletion - Frameshift	Large_intestine
COSM1075343	c.186G>A	p.Q62Q	Substitution - coding silent	Endometrium
COSM4663240	c.1481C>A	p.P494H	Substitution - Missense	Large_intestine
COSM740278	c.4978G>T	p.G1660*	Substitution - Nonsense	Lung
COSM1311748	c.1650G>T	p.P550P	Substitution - coding silent	Urinary_tract
COSM3769995	c.1472C>T	p.S491F	Substitution - Missense	Soft_tissue
COSM3622299	c.5890C>T	p.H1964Y	Substitution - Missense	Skin
COSM1441814	c.1989delC	p.P664fs*10	Deletion - Frameshift	Large_intestine
COSM3684020	c.2767G>C	p.A923P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3860002	c.5812T>C	p.S1938P	Substitution - Missense	Stomach
COSM5908596	c.1997C>T	p.P666L	Substitution - Missense	Skin
COSM3410731	c.2786C>T	p.A929V	Substitution - Missense	Stomach
COSM3622293	c.4986C>T	p.L1662L	Substitution - coding silent	Skin
COSM5733896	c.25C>T	p.H9Y	Substitution - Missense	Pancreas
COSM4663246	c.3181T>C	p.F1061L	Substitution - Missense	Large_intestine
COSM159176	c.3390C>G	p.Y1130*	Substitution - Nonsense	Breast
COSM4663256	c.4854G>A	p.A1618A	Substitution - coding silent	Large_intestine
COSM5902763	c.4841-6C>T	p.?	Unknown	Skin
COSM5922493	c.5641G>A	p.E1881K	Substitution - Missense	Skin
COSM4167420	c.1567C>T	p.P523S	Substitution - Missense	Central_nervous_system
COSM5019600	c.3960-7A>G	p.?	Unknown	Soft_tissue
COSM5768857	c.3810G>A	p.V1270V	Substitution - coding silent	Breast
COSM4808194	c.870A>C	p.A290A	Substitution - coding silent	Pancreas
COSM4619281	c.1629C>A	p.Y543*	Substitution - Nonsense	Large_intestine
COSM3859974	c.2896A>G	p.T966A	Substitution - Missense	Stomach
COSM1075359	c.5298C>T	p.F1766F	Substitution - coding silent	Endometrium
COSM6012573	c.6121C>T	p.P2041S	Substitution - Missense	Skin
COSM6012571	c.2411G>T	p.G804V	Substitution - Missense	Skin
COSM3674600	c.1982C>A	p.P661Q	Substitution - Missense	Prostate
COSM1621136	c.3348A>G	p.S1116S	Substitution - coding silent	Liver
COSM1183561	c.6581G>A	p.R2194H	Substitution - Missense	Large_intestine
COSM3622267	c.2346C>G	p.Y782*	Substitution - Nonsense	Skin
COSM3728410	c.1765G>A	p.G589R	Substitution - Missense	Breast
COSM5990852	c.75_76ins21	p.H41_L42insHHHHAHH	Insertion - In frame	Prostate
COSM3781610	c.768C>A	p.G256G	Substitution - coding silent	Prostate
COSM309264	c.2693A>C	p.Q898P	Substitution - Missense	Lung
COSM1642928	c.3169C>T	p.R1057*	Substitution - Nonsense	Skin
COSM3374116	c.4969C>A	p.Q1657K	Substitution - Missense	Thyroid
COSM3948317	c.4209C>T	p.G1403G	Substitution - coding silent	Lung
COSM3022421	c.5124C>T	p.D1708D	Substitution - coding silent	Prostate
COSM3622279	c.3743T>C	p.M1248T	Substitution - Missense	Skin
COSM159175	c.4829C>T	p.S1610F	Substitution - Missense	Breast
COSM4910980	c.3160T>A	p.W1054R	Substitution - Missense	Liver
COSM3747655	c.6513A>C	p.P2171P	Substitution - coding silent	Liver
COSM5472198	c.6016A>G	p.T2006A	Substitution - Missense	Large_intestine
COSM5811371	c.6086C>A	p.P2029Q	Substitution - Missense	Liver
COSM1642928	c.3169C>T	p.R1057*	Substitution - Nonsense	Stomach
COSM207151	c.5804G>A	p.R1935H	Substitution - Missense	Thyroid
COSM3430296	c.3948T>G	p.S1316R	Substitution - Missense	Large_intestine
COSM1236671	c.4307C>T	p.S1436L	Substitution - Missense	Autonomic_ganglia
COSM1441820	c.3655C>T	p.H1219Y	Substitution - Missense	Large_intestine
COSM3697628	c.195G>A	p.Q65Q	Substitution - coding silent	Large_intestine
COSM4656598	c.5884C>T	p.L1962F	Substitution - Missense	Large_intestine
COSM370221	c.5873G>T	p.G1958V	Substitution - Missense	Lung
COSM3859968	c.1958C>T	p.A653V	Substitution - Missense	Stomach
COSM3396632	c.5620G>A	p.A1874T	Substitution - Missense	Prostate
COSM3410735	c.4725C>T	p.T1575T	Substitution - coding silent	Central_nervous_system
COSM5959857	c.889_890insGCA	p.G297_G298insS	Insertion - In frame	Thyroid
COSM3928194	c.4591C>G	p.H1531D	Substitution - Missense	Central_nervous_system
COSM740281	c.4353T>C	p.N1451N	Substitution - coding silent	Lung
COSM5623683	c.784A>G	p.S262G	Substitution - Missense	Oesophagus
COSM5495845	c.5554G>C	p.E1852Q	Substitution - Missense	Biliary_tract
COSM5011706	c.4430G>A	p.R1477H	Substitution - Missense	Kidney
COSM5011708	c.6001G>T	p.V2001F	Substitution - Missense	Kidney
COSM1194909	c.2812G>T	p.A938S	Substitution - Missense	Lung
COSM4480599	c.2222C>T	p.P741L	Substitution - Missense	Skin
COSM243048	c.4270G>A	p.G1424R	Substitution - Missense	Prostate
COSM3622295	c.5704G>T	p.E1902*	Substitution - Nonsense	Skin
COSM3859970	c.2667-2A>G	p.?	Unknown	Stomach
COSM1731933	c.840_841insGTGGCG	p.A282_A283insVA	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM4160323	c.5895C>T	p.H1965H	Substitution - coding silent	Thyroid
COSM4987088	c.806G>C	p.G269A	Substitution - Missense	Soft_tissue
COSM1698225	c.3481C>T	p.Q1161*	Substitution - Nonsense	Skin
COSM88713	c.6496_6497insC	p.P2168fs*6	Insertion - Frameshift	Ovary
COSM1075351	c.4021G>T	p.G1341*	Substitution - Nonsense	Endometrium
COSM224313	c.5988G>A	p.W1996*	Substitution - Nonsense	Skin
COSM1727866	c.6097G>T	p.G2033C	Substitution - Missense	Liver
COSM4777220	c.6524A>G	p.D2175G	Substitution - Missense	Breast
COSM1731937	c.165_166insCAG	p.Q73_H74insQ	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM5469048	c.2158+5G>A	p.?	Unknown	Large_intestine
COSM1642928	c.3169C>T	p.R1057*	Substitution - Nonsense	Skin
COSM290980	c.4435_4442delGACGATAT	p.D1480fs*9	Deletion - Frameshift	Large_intestine
COSM3860002	c.5812T>C	p.S1938P	Substitution - Missense	Large_intestine
COSM4797119	c.6045G>A	p.G2015G	Substitution - coding silent	Liver
COSM3781610	c.768C>A	p.G256G	Substitution - coding silent	Kidney
COSM1075359	c.5298C>T	p.F1766F	Substitution - coding silent	Skin
COSM1737295	c.5384A>G	p.N1795S	Substitution - Missense	Central_nervous_system
COSM4663242	c.1857G>A	p.T619T	Substitution - coding silent	Large_intestine
COSM4794534	c.4253G>A	p.G1418E	Substitution - Missense	Liver
COSM5607852	c.2312C>T	p.P771L	Substitution - Missense	Skin
COSM5928778	c.2158+1G>A	p.?	Unknown	Skin
COSM5673236	c.3223G>T	p.V1075L	Substitution - Missense	Soft_tissue
COSM3674596	c.1553C>T	p.P518L	Substitution - Missense	Prostate
COSM1075359	c.5298C>T	p.F1766F	Substitution - coding silent	Endometrium
COSM5607864	c.4836T>G	p.D1612E	Substitution - Missense	Skin
COSM1716951	c.5181delG	p.E1728fs*20	Deletion - Frameshift	Ovary
COSM5020593	c.1764C>T	p.P588P	Substitution - coding silent	Soft_tissue
COSM5655931	c.160_198del39	p.F55_Q67del13	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM740282	c.4197G>A	p.R1399R	Substitution - coding silent	Lung
COSM4972093	c.748G>A	p.G250S	Substitution - Missense	Thyroid
COSM1742522	c.2954C>T	p.P985L	Substitution - Missense	Urinary_tract
COSM5713538	c.3382delA	p.I1128fs*65	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1642928	c.3169C>T	p.R1057*	Substitution - Nonsense	Skin
COSM5950915	c.2944A>G	p.I982V	Substitution - Missense	Prostate
COSM3781612	c.1941G>A	p.S647S	Substitution - coding silent	Pancreas
COSM1075353	c.4492G>A	p.V1498I	Substitution - Missense	Endometrium
COSM4663262	c.6475C>T	p.H2159Y	Substitution - Missense	Large_intestine
COSM3783954	c.6354G>A	p.S2118S	Substitution - coding silent	Oesophagus
COSM1238222	c.6345G>A	p.A2115A	Substitution - coding silent	Oesophagus
COSM5503186	c.4971G>A	p.Q1657Q	Substitution - coding silent	Biliary_tract
COSM5756809	c.4192C>T	p.R1398C	Substitution - Missense	Large_intestine
COSM1075366	c.6606C>T	p.G2202G	Substitution - coding silent	Endometrium
COSM1075348	c.3510C>A	p.S1170S	Substitution - coding silent	Endometrium
COSM1698225	c.3481C>T	p.Q1161*	Substitution - Nonsense	Skin
COSM5979286	c.3742A>G	p.M1248V	Substitution - Missense	Upper_aerodigestive_tract
COSM1075350	c.3865C>T	p.Q1289*	Substitution - Nonsense	Endometrium
COSM1716951	c.5181delG	p.E1728fs*20	Deletion - Frameshift	Ovary
COSM1621136	c.3348A>G	p.S1116S	Substitution - coding silent	Liver
COSM5607854	c.1839C>T	p.S613S	Substitution - coding silent	Skin
COSM5975875	c.3606C>T	p.H1202H	Substitution - coding silent	Upper_aerodigestive_tract
COSM5893089	c.6116T>G	p.V2039G	Substitution - Missense	Skin
COSM4406882	c.4578G>A	p.P1526P	Substitution - coding silent	Soft_tissue
COSM1441832	c.5872G>T	p.G1958W	Substitution - Missense	Large_intestine
COSM3859988	c.4687C>T	p.Q1563*	Substitution - Nonsense	Stomach
COSM1183563	c.3349A>C	p.S1117R	Substitution - Missense	Large_intestine
COSM5564106	c.3170G>A	p.R1057Q	Substitution - Missense	Prostate
COSM5607870	c.2456C>T	p.P819L	Substitution - Missense	Skin
COSM1075359	c.5298C>T	p.F1766F	Substitution - coding silent	Skin
COSM5720825	c.2861C>T	p.P954L	Substitution - Missense	Skin
COSM3022409	c.4857G>A	p.W1619*	Substitution - Nonsense	Stomach
COSM3859976	c.3699G>T	p.R1233R	Substitution - coding silent	Stomach
COSM4170077	c.188_189insGC	p.Q64fs*59	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1075343	c.186G>A	p.Q62Q	Substitution - coding silent	Biliary_tract
COSM3622289	c.4632C>T	p.S1544S	Substitution - coding silent	Skin
COSM5549930	c.1205C>G	p.A402G	Substitution - Missense	Prostate
COSM5996929	c.6042C>G	p.S2014S	Substitution - coding silent	Prostate
COSM5518713	c.1421G>A	p.G474D	Substitution - Missense	Biliary_tract
COSM5899504	c.2452C>T	p.Q818*	Substitution - Nonsense	Skin
COSM4186698	c.5110C>A	p.Q1704K	Substitution - Missense	Kidney
COSM5607856	c.3488C>T	p.P1163L	Substitution - Missense	Skin
COSM4793138	c.3285G>A	p.L1095L	Substitution - coding silent	Liver
COSM5607848	c.1907G>A	p.S636N	Substitution - Missense	Skin
COSM3022248	c.1592T>C	p.V531A	Substitution - Missense	Large_intestine
COSM3622277	c.3722C>T	p.P1241L	Substitution - Missense	Skin
COSM309264	c.2693A>C	p.Q898P	Substitution - Missense	Soft_tissue
COSM450794	c.1959G>A	p.A653A	Substitution - coding silent	Large_intestine
COSM740274	c.6018G>T	p.T2006T	Substitution - coding silent	Lung
COSM3859988	c.4687C>T	p.Q1563*	Substitution - Nonsense	Skin
COSM1698225	c.3481C>T	p.Q1161*	Substitution - Nonsense	Skin
COSM450797	c.3670G>C	p.D1224H	Substitution - Missense	Breast
COSM4663248	c.3586A>G	p.T1196A	Substitution - Missense	Large_intestine
COSM483609	c.3708G>A	p.M1236I	Substitution - Missense	Kidney
COSM5445872	c.897_898insGGC	p.G299_Y300insG	Insertion - In frame	Thyroid
COSM4748045	c.3527delC	p.Q1178fs*15	Deletion - Frameshift	Stomach
COSM3829520	c.3409A>T	p.K1137*	Substitution - Nonsense	Breast
COSM4171525	c.5758C>T	p.Q1920*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5005736	c.6073A>C	p.S2025R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3928196	c.4678A>G	p.M1560V	Substitution - Missense	Central_nervous_system
COSM740286	c.1519C>T	p.R507W	Substitution - Missense	Lung
COSM5503188	c.6165C>T	p.N2055N	Substitution - coding silent	Biliary_tract
COSM1075356	c.4945A>T	p.T1649S	Substitution - Missense	Endometrium
COSM5975877	c.3663A>G	p.P1221P	Substitution - coding silent	Upper_aerodigestive_tract
COSM5607862	c.6168G>A	p.S2056S	Substitution - coding silent	Skin
COSM1075354	c.4571C>T	p.T1524M	Substitution - Missense	Endometrium
COSM5455463	c.4349G>A	p.R1450H	Substitution - Missense	Large_intestine
COSM4186696	c.2265delT	p.G756fs*18	Deletion - Frameshift	Kidney
COSM1441812	c.1934C>T	p.A645V	Substitution - Missense	Large_intestine
COSM3622287	c.4631C>T	p.S1544F	Substitution - Missense	Skin
COSM3734981	c.5941G>T	p.E1981*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM1245450	c.3463A>T	p.K1155*	Substitution - Nonsense	Oesophagus
COSM4763094	c.2922+1G>A	p.?	Unknown	Stomach
COSM3829526	c.6386G>C	p.R2129T	Substitution - Missense	Breast
COSM5607850	c.5063C>A	p.P1688H	Substitution - Missense	Skin
COSM4993701	c.780_782delAGG	p.G261delG	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM174860	c.6328C>T	p.R2110*	Substitution - Nonsense	Stomach
COSM1183551	c.797G>C	p.G266A	Substitution - Missense	Large_intestine
COSM1698227	c.3887C>T	p.P1296L	Substitution - Missense	Skin
COSM1642932	c.6331G>T	p.E2111*	Substitution - Nonsense	Stomach
COSM1183557	c.4250C>T	p.P1417L	Substitution - Missense	Large_intestine
COSM3622265	c.1852C>T	p.P618S	Substitution - Missense	Skin
COSM4918907	c.4589A>G	p.N1530S	Substitution - Missense	Liver
COSM4421413	c.6111G>C	p.W2037C	Substitution - Missense	Pleura
COSM1545496	c.4217C>T	p.P1406L	Substitution - Missense	Large_intestine
COSM3859980	c.3919C>T	p.Q1307*	Substitution - Nonsense	Stomach
COSM3729372	c.2720C>T	p.P907L	Substitution - Missense	Stomach
COSM397320	c.1973C>T	p.S658F	Substitution - Missense	Lung
COSM243049	c.1159_1160insCGC	p.P392_S393insP	Insertion - In frame	Prostate
COSM5024885	c.49G>C	p.A17P	Substitution - Missense	Breast
COSM4802669	c.6584C>A	p.S2195*	Substitution - Nonsense	Liver
COSM5996707	c.5480G>A	p.R1827H	Substitution - Missense	Prostate
COSM5564287	c.3634A>C	p.R1212R	Substitution - coding silent	Prostate
COSM5482030	c.5350C>T	p.R1784*	Substitution - Nonsense	Large_intestine
COSM5440315	c.3996_3997insCCTA	p.P1334fs*108	Insertion - Frameshift	Oesophagus
COSM3728410	c.1765G>A	p.G589R	Substitution - Missense	Soft_tissue
COSM1731935	c.744_745insGGC	p.G261_S262insG	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM3022510	c.6672A>G	p.V2224V	Substitution - coding silent	Large_intestine
COSM3622291	c.4669C>T	p.L1557L	Substitution - coding silent	Skin
COSM450800	c.5294A>C	p.K1765T	Substitution - Missense	Breast
COSM5928776	c.2158G>A	p.G720S	Substitution - Missense	Skin
COSM3829514	c.46G>A	p.E16K	Substitution - Missense	Breast
COSM5460707	c.5134A>G	p.K1712E	Substitution - Missense	Large_intestine
COSM1634599	c.1936C>T	p.Q646*	Substitution - Nonsense	Liver
COSM1621134	c.3277G>A	p.G1093R	Substitution - Missense	Liver
COSM243047	c.5265C>A	p.D1755E	Substitution - Missense	Prostate
COSM1183559	c.1528G>A	p.G510R	Substitution - Missense	Large_intestine
COSM483610	c.4056G>C	p.P1352P	Substitution - coding silent	Kidney
COSM5720825	c.2861C>T	p.P954L	Substitution - Missense	Skin
COSM1731937	c.165_166insCAG	p.Q73_H74insQ	Insertion - In frame	Central_nervous_system
COSM5019255	c.1504A>G	p.I502V	Substitution - Missense	Soft_tissue
COSM5611228	c.3886_3887CC>TT	p.P1296F	Substitution - Missense	Skin
COSM5596290	c.3052C>T	p.P1018S	Substitution - Missense	Skin
COSM1163427	c.6576A>C	p.E2192D	Substitution - Missense	Pancreas
COSM1471908	c.2167G>A	p.A723T	Substitution - Missense	Prostate
COSM3920982	c.3462C>A	p.T1154T	Substitution - coding silent	Skin
COSM4589822	c.3792_3793insG	p.M1267fs*36	Insertion - Frameshift	Skin
COSM371984	c.6042_6043CG>TT	p.S2014>?	Complex	Lung
COSM3697628	c.195G>A	p.Q65Q	Substitution - coding silent	Large_intestine
COSM1642930	c.5337G>A	p.L1779L	Substitution - coding silent	Stomach
COSM3674598	c.1558C>T	p.Q520*	Substitution - Nonsense	Prostate
COSM4663254	c.4182G>A	p.S1394S	Substitution - coding silent	Large_intestine
COSM1441830	c.5619C>T	p.D1873D	Substitution - coding silent	Large_intestine
COSM3859990	c.4838T>A	p.I1613N	Substitution - Missense	Stomach
COSM4797119	c.6045G>A	p.G2015G	Substitution - coding silent	Liver

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
27063598	mutation (loss of function)	Leukemia	Our sequencing data also demonstrates incidence of loss-of-function mutations in previously unidentified genes, ARID1B and ARID1A, both of which encode for key components of the SWI/SNF complex.
26892443	mutation	Spitzoid Melanoma	In addition, two tumors each contained a second fusion gene, ARID1B-SNX9 or PTPRZ1-NFAM1.
26336887	mutation	Mesonephric Carcinoma	Mutations in chromatin remodeling genes (ARID1A, ARID1B, or SMARCA4) were present in 62% of mesonephric carcinomas.
25549701	mutation	Meningioma	From exome sequencing data, we identified several frequently mutated genes including NF2, MN1, ARID1B, SEMA4D, and MUC2, with private mutations in tumors.
25233892	mutation	Carcinosarcoma	In addition to mutations in TP53 and KRAS, we identify genetic alterations in chromatin remodelling genes, ARID1A and ARID1B, in histone methyltransferase MLL3, in histone deacetylase modifier SPOP and in chromatin assembly factor BAZ1A, in nearly two thirds of cases.
23202128	mutation; copy number loss	Neuroblastoma	Among genes not previously known to be involved in neuroblastoma, chromosomal deletions and sequence alterations of the chromatin-remodeling genes ARID1A and ARID1B were identified in 8 of 71 tumors (11%) and were associated with early treatment failure and decreased survival.
22722201	mutation	Breast Carcinoma	Driver mutations were identified in several new cancer genes including AKT2, ARID1B, CASP8, CDKN1B, MAP3K1, MAP3K13, NCOR1, SMARCD1 and TBX3.
22233809	mutation	Pancreatic Carcinoma	Notable among the alterations newly identified, genomic deletions, mutations, and rearrangements recurrently targeted genes encoding components of the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex, including all three putative DNA binding subunits (ARID1A, ARID1B, and PBRM1) and both enzymatic subunits (SMARCA2 and SMARCA4).
22634756	mutation	Hepatocellular Carcinoma	Multiple chromatin regulators, including ARID1A, ARID1B, ARID2, MLL and MLL3, were mutated in 50% of the tumors.
24382590	mutation	Colorectal Carcinoma	We found that in addition to ARID1A, which was mutated in 39% of the tumors (18/46), also ARID1B (13%, 6/46), ARID2 (13%, 6/46) and ARID4A (20%, 9/46) were frequently mutated.
25370573	mutation	Lung Carcinoma	Specifically, the mutant-typing of 6 BAF genes, SMARCA4, ARID2, ARID1B, BCL11A, BCL11B and BRD9 was associated with more overall mutations in the lung carcinoma samples.
26221190	mutation	Melanoma	Of the 40 most commonly mutated genes, 12 (30.0%) encoded epigenetic regulators, including genes encoding enzymes involved in histone modification (MECOM, MLL2, SETD2), chromatin remodeling (ARID1B, ARID2), and DNA methylation and demethylation (TET2, IDH1).
27392123	mutation	Leukemia	Seven of the 240 patients were identified to have ZNF384 gene rearrangements including partner genes TCF3 (four patients), EWSR1 (one patient), EP300 (one patient), and the novel gene partner ARID1B (one patient).
27562491	mutation (loss of function)	Endometrial Undifferentiated Carcinoma; Undifferentiated Ovarian Carcinoma	We identified concurrent inactivating mutations involving ARID1A and ARID1B in 12 of 24 BRG1/INI1-intact, 0 of 3 INI1-deficient and 0 of 16 BRG1-deficient dedifferentiated carcinomas.
28122867	mutation	Hepatosplenic T-cell Lymphoma	Chromatin-modifying genes, including SETD2, INO80, and ARID1B, were commonly mutated in HSTL, affecting 62% of cases.
27723760	mutation	Schwannoma	Exome sequence analysis with validation by targeted DNA sequencing of 125 samples uncovered, in addition to expected NF2 disruption, recurrent mutations in ARID1A, ARID1B and DDR1.
27723760	mutation	Schwannoma	Exome sequence analysis with validation by targeted DNA sequencing of 125 samples uncovered, in addition to expected NF2 disruption, recurrent mutations in ARID1A, ARID1B and DDR1.

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8NFD5	502	S	Phosphoserine	-	No	None detected
Q8NFD5	516	S	Phosphoserine	-	No	None detected
Q8NFD5	557	R	Asymmetric dimethylarginine	-	No	None detected
Q8NFD5	1542	S	Phosphoserine	-	No	None detected
Q8NFD5	1555	S	Phosphoserine	-	No	None detected
Q8NFD5	1559	S	Phosphoserine	-	No	None detected
Q8NFD5	1715	S	Phosphoserine	-	No	None detected
Q8NFD5	1777	K	N6-acetyllysine	-	No	None detected

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.631	6.107	-0.475	0.00155	NS
BRCA	Breast invasive carcinoma	112	1100	6.811	6.509	-0.317	2.92e-09	NS
CESC	Cervical and endocervical cancers	3	306	6.512	6.127	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.235	6.227	-0.034	0.652	NS
ESCA	Esophageal carcinoma	11	185	7.137	7.001	-0.169	0.279	NS
GBM	Glioblastoma multiforme	5	166	6.463	5.824	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.556	6.176	-0.374	0.000157	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.498	6.007	-0.55	1.16e-20	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.529	5.854	-0.663	4.2e-10	Under
LAML	Acute Myeloid Leukemia	0	173	NA	8.091	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.375	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.812	4.563	-0.292	0.00358	NS
LUAD	Lung adenocarcinoma	59	517	6.398	6.119	-0.254	0.000368	NS
LUSC	Lung squamous cell carcinoma	51	501	6.459	6.266	-0.073	0.399	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.563	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.474	6.128	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.908	5.963	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.616	6.379	-0.27	0.0213	NS
READ	Rectum adenocarcinoma	10	167	6.236	6.321	0.123	0.522	NS
SARC	Sarcoma	2	263	5.65	6.222	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.763	6.226	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.961	6.839	-0.123	0.203	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.079	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.101	6.668	-0.394	1.01e-10	NS
THYM	Thymoma	2	120	6.858	6.39	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.595	6.295	-0.388	0.000186	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.2
Autonomic ganglia	CHP212	7.2
Autonomic ganglia	IMR32	8.3
Autonomic ganglia	KELLY	7.6
Autonomic ganglia	KPNRTBM1	8.3
Autonomic ganglia	KPNSI9S	6.8
Autonomic ganglia	KPNYN	7.6
Autonomic ganglia	MHHNB11	7.5
Autonomic ganglia	NB1	7.3
Autonomic ganglia	NH6	7.7
Autonomic ganglia	SHSY5Y	8.2
Autonomic ganglia	SIMA	8
Autonomic ganglia	SKNAS	6.2
Autonomic ganglia	SKNBE2	7.4
Autonomic ganglia	SKNDZ	7.5
Autonomic ganglia	SKNFI	6.9
Autonomic ganglia	SKNSH	7
Biliary tract	HUCCT1	6.1
Biliary tract	HUH28	7.3
Biliary tract	SNU1079	6.3
Biliary tract	SNU1196	6.9
Biliary tract	SNU245	7.1
Biliary tract	SNU308	6.4
Biliary tract	SNU478	7.1
Bone	143B	6.6
Bone	A673	6.9
Bone	CADOES1	7.6
Bone	CAL78	6.7
Bone	G292CLONEA141B1	6.6
Bone	HOS	7
Bone	HS706T	6.8
Bone	HS737T	6.5
Bone	HS819T	6.4
Bone	HS821T	6.7
Bone	HS822T	6.2
Bone	HS863T	6.5
Bone	HS870T	6.2
Bone	HS888T	6.7
Bone	MG63	6.5
Bone	MHHES1	7.6
Bone	OUMS27	5.5
Bone	RDES	7.2
Bone	SJSA1	6.6
Bone	SKES1	6.9
Bone	SKNMC	7.9
Bone	SW1353	6.7
Bone	T173	6.2
Bone	TC71	7.1
Bone	U2OS	7
Breast	AU565	7
Breast	BT20	6.8
Breast	BT474	7
Breast	BT483	6.9
Breast	BT549	6.9
Breast	CAL120	6.9
Breast	CAL148	7.4
Breast	CAL51	7.8
Breast	CAL851	5.7
Breast	CAMA1	6.8
Breast	DU4475	7.3
Breast	EFM192A	6.8
Breast	EFM19	7.6
Breast	EVSAT	7.1
Breast	HCC1143	6.8
Breast	HCC1187	7.1
Breast	HCC1395	6.8
Breast	HCC1419	7.7
Breast	HCC1428	6.9
Breast	HCC1500	7.7
Breast	HCC1569	6.6
Breast	HCC1599	7.1
Breast	HCC1806	7.1
Breast	HCC1937	5.8
Breast	HCC1954	6.5
Breast	HCC202	5.9
Breast	HCC2157	6.9
Breast	HCC2218	7
Breast	HCC38	6.4
Breast	HCC70	6.6
Breast	HDQP1	7.4
Breast	HMC18	6.9
Breast	HS274T	6.5
Breast	HS281T	6.6
Breast	HS343T	6.7
Breast	HS578T	6.3
Breast	HS606T	6.7
Breast	HS739T	6.6
Breast	HS742T	6.5
Breast	JIMT1	6.7
Breast	KPL1	6.6
Breast	MCF7	6.2
Breast	MDAMB134VI	7.3
Breast	MDAMB157	6.4
Breast	MDAMB175VII	7
Breast	MDAMB231	5.8
Breast	MDAMB361	7
Breast	MDAMB415	6.5
Breast	MDAMB436	6.4
Breast	MDAMB453	7.2
Breast	MDAMB468	6.7
Breast	SKBR3	7.2
Breast	T47D	7
Breast	UACC812	7.4
Breast	UACC893	7.4
Breast	YMB1	6.8
Breast	ZR751	6.5
Breast	ZR7530	7.3
Central nervous system	1321N1	6.9
Central nervous system	42MGBA	6.8
Central nervous system	8MGBA	6.6
Central nervous system	A172	6.7
Central nervous system	AM38	6.3
Central nervous system	BECKER	6.9
Central nervous system	CAS1	7.1
Central nervous system	CCFSTTG1	6.6
Central nervous system	D283MED	7.3
Central nervous system	D341MED	7.8
Central nervous system	DAOY	7.9
Central nervous system	DBTRG05MG	6.4
Central nervous system	DKMG	6.4
Central nervous system	GAMG	6.7
Central nervous system	GB1	6.8
Central nervous system	GI1	6.9
Central nervous system	GMS10	6.4
Central nervous system	GOS3	6
Central nervous system	H4	5.9
Central nervous system	HS683	6.8
Central nervous system	KALS1	7
Central nervous system	KG1C	6.4
Central nervous system	KNS42	6.7
Central nervous system	KNS60	6.7
Central nervous system	KNS81	6.8
Central nervous system	KS1	6.7
Central nervous system	LN18	6.3
Central nervous system	LN229	6.1
Central nervous system	M059K	7.2
Central nervous system	MOGGCCM	6.9
Central nervous system	MOGGUVW	6.9
Central nervous system	NMCG1	6.5
Central nervous system	ONS76	6.8
Central nervous system	SF126	6.4
Central nervous system	SF295	6.3
Central nervous system	SNB19	6.9
Central nervous system	SNU1105	7.3
Central nervous system	SNU201	7
Central nervous system	SNU466	6.1
Central nervous system	SNU489	7.2
Central nervous system	SNU626	6.8
Central nervous system	SNU738	7.1
Central nervous system	SW1088	6.6
Central nervous system	SW1783	6.8
Central nervous system	T98G	6.1
Central nervous system	TM31	7.4
Central nervous system	U118MG	7.1
Central nervous system	U138MG	6.9
Central nervous system	U251MG	6.5
Central nervous system	U87MG	6.4
Central nervous system	YH13	7
Central nervous system	YKG1	6.7
Endometrium	AN3CA	7.2
Endometrium	COLO684	7.4
Endometrium	EFE184	6.2
Endometrium	EN	6.8
Endometrium	ESS1	6
Endometrium	HEC108	7.5
Endometrium	HEC151	6.7
Endometrium	HEC1A	6.9
Endometrium	HEC1B	6.7
Endometrium	HEC251	6.2
Endometrium	HEC265	6.9
Endometrium	HEC50B	6.9
Endometrium	HEC59	7.2
Endometrium	HEC6	7.6
Endometrium	ISHIKAWAHERAKLIO02ER	7
Endometrium	JHUEM1	6.7
Endometrium	JHUEM2	7.4
Endometrium	JHUEM3	6.8
Endometrium	KLE	6.1
Endometrium	MFE280	6.5
Endometrium	MFE296	6
Endometrium	MFE319	6.5
Endometrium	RL952	6.9
Endometrium	SNGM	6.7
Endometrium	SNU1077	7.7
Endometrium	SNU685	6.9
Endometrium	TEN	6.3
Haematopoietic and lymphoid	697	8
Haematopoietic and lymphoid	A3KAW	6.7
Haematopoietic and lymphoid	A4FUK	7.6
Haematopoietic and lymphoid	ALLSIL	8
Haematopoietic and lymphoid	AML193	7.9
Haematopoietic and lymphoid	AMO1	7.4
Haematopoietic and lymphoid	BCP1	6.8
Haematopoietic and lymphoid	BDCM	7.8
Haematopoietic and lymphoid	BL41	8.2
Haematopoietic and lymphoid	BL70	7.6
Haematopoietic and lymphoid	BV173	7.6
Haematopoietic and lymphoid	CA46	7.9
Haematopoietic and lymphoid	CI1	7.6
Haematopoietic and lymphoid	CMK115	7.3
Haematopoietic and lymphoid	CMK86	8
Haematopoietic and lymphoid	CMK	7.1
Haematopoietic and lymphoid	CMLT1	7.8
Haematopoietic and lymphoid	COLO775	7
Haematopoietic and lymphoid	DAUDI	7.9
Haematopoietic and lymphoid	DB	7.4
Haematopoietic and lymphoid	DEL	7
Haematopoietic and lymphoid	DND41	7.8
Haematopoietic and lymphoid	DOHH2	8.9
Haematopoietic and lymphoid	EB1	7.4
Haematopoietic and lymphoid	EB2	7.3
Haematopoietic and lymphoid	EHEB	7.6
Haematopoietic and lymphoid	EJM	6.8
Haematopoietic and lymphoid	EM2	8.3
Haematopoietic and lymphoid	EOL1	8.1
Haematopoietic and lymphoid	F36P	8.2
Haematopoietic and lymphoid	GA10	7.7
Haematopoietic and lymphoid	GDM1	6.9
Haematopoietic and lymphoid	GRANTA519	8.6
Haematopoietic and lymphoid	HDLM2	7.5
Haematopoietic and lymphoid	HDMYZ	6.9
Haematopoietic and lymphoid	HEL9217	7.2
Haematopoietic and lymphoid	HEL	7.7
Haematopoietic and lymphoid	HH	7
Haematopoietic and lymphoid	HL60	7.6
Haematopoietic and lymphoid	HPBALL	8
Haematopoietic and lymphoid	HS604T	6.4
Haematopoietic and lymphoid	HS611T	7.4
Haematopoietic and lymphoid	HS616T	6.4
Haematopoietic and lymphoid	HS751T	6.5
Haematopoietic and lymphoid	HT	7.4
Haematopoietic and lymphoid	HTK	6.8
Haematopoietic and lymphoid	HUNS1	7.6
Haematopoietic and lymphoid	HUT102	7
Haematopoietic and lymphoid	HUT78	7.3
Haematopoietic and lymphoid	JEKO1	7.4
Haematopoietic and lymphoid	JK1	7.4
Haematopoietic and lymphoid	JM1	7.8
Haematopoietic and lymphoid	JURKAT	7.6
Haematopoietic and lymphoid	JURLMK1	7.8
Haematopoietic and lymphoid	JVM2	6.7
Haematopoietic and lymphoid	JVM3	8
Haematopoietic and lymphoid	K562	6.7
Haematopoietic and lymphoid	KARPAS299	7.1
Haematopoietic and lymphoid	KARPAS422	8.2
Haematopoietic and lymphoid	KARPAS620	8.9
Haematopoietic and lymphoid	KASUMI1	7.9
Haematopoietic and lymphoid	KASUMI2	8.6
Haematopoietic and lymphoid	KASUMI6	8.7
Haematopoietic and lymphoid	KCL22	8
Haematopoietic and lymphoid	KE37	7.9
Haematopoietic and lymphoid	KE97	6.9
Haematopoietic and lymphoid	KG1	7.4
Haematopoietic and lymphoid	KHM1B	7.3
Haematopoietic and lymphoid	KIJK	6.5
Haematopoietic and lymphoid	KMH2	7.7
Haematopoietic and lymphoid	KMM1	7.3
Haematopoietic and lymphoid	KMS11	7.5
Haematopoietic and lymphoid	KMS12BM	7.3
Haematopoietic and lymphoid	KMS18	7.7
Haematopoietic and lymphoid	KMS20	7.5
Haematopoietic and lymphoid	KMS21BM	7
Haematopoietic and lymphoid	KMS26	7.5
Haematopoietic and lymphoid	KMS27	5.9
Haematopoietic and lymphoid	KMS28BM	7.3
Haematopoietic and lymphoid	KMS34	6.8
Haematopoietic and lymphoid	KO52	8.5
Haematopoietic and lymphoid	KOPN8	8
Haematopoietic and lymphoid	KU812	8.4
Haematopoietic and lymphoid	KYO1	7.4
Haematopoietic and lymphoid	L1236	6.8
Haematopoietic and lymphoid	L363	7.5
Haematopoietic and lymphoid	L428	7
Haematopoietic and lymphoid	L540	6.8
Haematopoietic and lymphoid	LAMA84	8.3
Haematopoietic and lymphoid	LOUCY	7.7
Haematopoietic and lymphoid	LP1	7.5
Haematopoietic and lymphoid	M07E	7.8
Haematopoietic and lymphoid	MC116	7.3
Haematopoietic and lymphoid	ME1	8.1
Haematopoietic and lymphoid	MEC1	7.7
Haematopoietic and lymphoid	MEC2	7.8
Haematopoietic and lymphoid	MEG01	7.4
Haematopoietic and lymphoid	MHHCALL2	8.3
Haematopoietic and lymphoid	MHHCALL3	8.3
Haematopoietic and lymphoid	MHHCALL4	8.6
Haematopoietic and lymphoid	MINO	7.9
Haematopoietic and lymphoid	MJ	7.2
Haematopoietic and lymphoid	MM1S	6.5
Haematopoietic and lymphoid	MOLM13	7.6
Haematopoietic and lymphoid	MOLM16	7.4
Haematopoietic and lymphoid	MOLM6	7.6
Haematopoietic and lymphoid	MOLP2	6.7
Haematopoietic and lymphoid	MOLP8	8.3
Haematopoietic and lymphoid	MOLT13	8.7
Haematopoietic and lymphoid	MOLT16	7.7
Haematopoietic and lymphoid	MOLT4	7.3
Haematopoietic and lymphoid	MONOMAC1	7.3
Haematopoietic and lymphoid	MONOMAC6	7.5
Haematopoietic and lymphoid	MOTN1	7.7
Haematopoietic and lymphoid	MUTZ5	8.3
Haematopoietic and lymphoid	MV411	7.2
Haematopoietic and lymphoid	NALM19	9.2
Haematopoietic and lymphoid	NALM1	8.6
Haematopoietic and lymphoid	NALM6	8
Haematopoietic and lymphoid	NAMALWA	8
Haematopoietic and lymphoid	NB4	7.7
Haematopoietic and lymphoid	NCIH929	7.2
Haematopoietic and lymphoid	NCO2	8.3
Haematopoietic and lymphoid	NOMO1	6.9
Haematopoietic and lymphoid	NUDHL1	7.7
Haematopoietic and lymphoid	NUDUL1	8.8
Haematopoietic and lymphoid	OCIAML2	7.5
Haematopoietic and lymphoid	OCIAML3	7.2
Haematopoietic and lymphoid	OCIAML5	7.4
Haematopoietic and lymphoid	OCILY10	7.9
Haematopoietic and lymphoid	OCILY19	9.2
Haematopoietic and lymphoid	OCILY3	6.8
Haematopoietic and lymphoid	OCIM1	7.9
Haematopoietic and lymphoid	OPM2	8.2
Haematopoietic and lymphoid	P12ICHIKAWA	7.5
Haematopoietic and lymphoid	P31FUJ	7
Haematopoietic and lymphoid	P3HR1	7.2
Haematopoietic and lymphoid	PCM6	6.9
Haematopoietic and lymphoid	PEER	7.4
Haematopoietic and lymphoid	PF382	7.6
Haematopoietic and lymphoid	PFEIFFER	7.4
Haematopoietic and lymphoid	PL21	8
Haematopoietic and lymphoid	RAJI	7.2
Haematopoietic and lymphoid	RCHACV	8.4
Haematopoietic and lymphoid	REC1	7.2
Haematopoietic and lymphoid	REH	8.4
Haematopoietic and lymphoid	RI1	7.2
Haematopoietic and lymphoid	RL	7.1
Haematopoietic and lymphoid	RPMI8226	7.2
Haematopoietic and lymphoid	RPMI8402	9.1
Haematopoietic and lymphoid	RS411	7.6
Haematopoietic and lymphoid	SEM	8.5
Haematopoietic and lymphoid	SET2	7.7
Haematopoietic and lymphoid	SIGM5	7.3
Haematopoietic and lymphoid	SKM1	7.3
Haematopoietic and lymphoid	SKMM2	7.4
Haematopoietic and lymphoid	SR786	7.3
Haematopoietic and lymphoid	ST486	7.8
Haematopoietic and lymphoid	SUDHL10	7.9
Haematopoietic and lymphoid	SUDHL1	6.7
Haematopoietic and lymphoid	SUDHL4	8.2
Haematopoietic and lymphoid	SUDHL5	6.3
Haematopoietic and lymphoid	SUDHL6	8
Haematopoietic and lymphoid	SUDHL8	9.7
Haematopoietic and lymphoid	SUPB15	7.8
Haematopoietic and lymphoid	SUPHD1	6.9
Haematopoietic and lymphoid	SUPM2	6.7
Haematopoietic and lymphoid	SUPT11	7
Haematopoietic and lymphoid	SUPT1	7.3
Haematopoietic and lymphoid	TALL1	8.3
Haematopoietic and lymphoid	TF1	7.5
Haematopoietic and lymphoid	THP1	7.4
Haematopoietic and lymphoid	TO175T	6.6
Haematopoietic and lymphoid	TOLEDO	7.8
Haematopoietic and lymphoid	U266B1	7.4
Haematopoietic and lymphoid	U937	7.8
Haematopoietic and lymphoid	UT7	8.6
Haematopoietic and lymphoid	WSUDLCL2	7.8
Kidney	769P	6.9
Kidney	786O	6.2
Kidney	A498	5.9
Kidney	A704	6
Kidney	ACHN	6.3
Kidney	BFTC909	6.9
Kidney	CAKI1	6.6
Kidney	CAKI2	4.9
Kidney	CAL54	6.8
Kidney	KMRC1	6.9
Kidney	KMRC20	7
Kidney	KMRC2	6.9
Kidney	KMRC3	5.6
Kidney	OSRC2	6.3
Kidney	RCC10RGB	6
Kidney	SNU1272	5.9
Kidney	SNU349	6.9
Kidney	TUHR10TKB	7
Kidney	TUHR14TKB	6.1
Kidney	TUHR4TKB	6.6
Kidney	VMRCRCW	6.5
Kidney	VMRCRCZ	6.9
Large intestine	C2BBE1	6.4
Large intestine	CCK81	7.2
Large intestine	CL11	6.5
Large intestine	CL14	7.4
Large intestine	CL34	7.2
Large intestine	CL40	7.1
Large intestine	COLO205	6.5
Large intestine	COLO320	7.1
Large intestine	COLO678	6.6
Large intestine	CW2	6.8
Large intestine	DLD1	6.3
Large intestine	GP2D	7
Large intestine	HCC56	6.9
Large intestine	HCT116	6.7
Large intestine	HCT15	6.4
Large intestine	HS675T	6.3
Large intestine	HS698T	6.8
Large intestine	HT115	6.9
Large intestine	HT29	6.9
Large intestine	HT55	7.3
Large intestine	KM12	6.8
Large intestine	LOVO	7
Large intestine	LS1034	7
Large intestine	LS123	6.7
Large intestine	LS180	7.3
Large intestine	LS411N	7.2
Large intestine	LS513	6.8
Large intestine	MDST8	6.7
Large intestine	NCIH508	6.8
Large intestine	NCIH716	6.8
Large intestine	NCIH747	7.1
Large intestine	OUMS23	7.5
Large intestine	RCM1	6.7
Large intestine	RKO	6.4
Large intestine	SKCO1	7.4
Large intestine	SNU1040	6.6
Large intestine	SNU1197	6.7
Large intestine	SNU175	7.3
Large intestine	SNU283	7
Large intestine	SNU407	7.4
Large intestine	SNU503	6.6
Large intestine	SNU61	7.2
Large intestine	SNU81	7.4
Large intestine	SNUC1	6.9
Large intestine	SNUC2A	7.6
Large intestine	SNUC4	7.2
Large intestine	SNUC5	7.4
Large intestine	SW1116	7.4
Large intestine	SW1417	7
Large intestine	SW1463	6.8
Large intestine	SW403	7.1
Large intestine	SW480	6
Large intestine	SW48	6.9
Large intestine	SW620	7
Large intestine	SW837	6.9
Large intestine	SW948	7
Large intestine	T84	7.3
Liver	ALEXANDERCELLS	6.9
Liver	C3A	7
Liver	HEP3B217	7
Liver	HEPG2	7.1
Liver	HLE	6.8
Liver	HLF	6.8
Liver	HUH1	6.4
Liver	HUH6	6.8
Liver	HUH7	6.9
Liver	JHH1	5.6
Liver	JHH2	7.1
Liver	JHH4	6.8
Liver	JHH5	6.3
Liver	JHH6	7
Liver	JHH7	7.7
Liver	LI7	7
Liver	PLCPRF5	7
Liver	SKHEP1	6.6
Liver	SNU182	7.4
Liver	SNU387	7.1
Liver	SNU398	7.2
Liver	SNU423	7.2
Liver	SNU449	6.5
Liver	SNU475	6.3
Liver	SNU761	6.6
Liver	SNU878	6.3
Liver	SNU886	7.4
Lung	A549	5.9
Lung	ABC1	6.7
Lung	BEN	6.7
Lung	CAL12T	6.3
Lung	CALU1	6.6
Lung	CALU3	6.5
Lung	CALU6	6.9
Lung	CHAGOK1	6.9
Lung	COLO668	7.5
Lung	COLO699	8.1
Lung	CORL105	6
Lung	CORL23	6.2
Lung	CORL24	7.8
Lung	CORL279	7.4
Lung	CORL311	7.6
Lung	CORL47	7.1
Lung	CORL51	7.8
Lung	CORL88	8.7
Lung	CORL95	7.5
Lung	CPCN	7.3
Lung	DMS114	6.9
Lung	DMS153	6.7
Lung	DMS273	7
Lung	DMS454	6.9
Lung	DMS53	7.6
Lung	DMS79	7.5
Lung	DV90	6.7
Lung	EBC1	6.4
Lung	EPLC272H	5.7
Lung	HARA	6.4
Lung	HCC1171	6.7
Lung	HCC1195	6.4
Lung	HCC15	6.8
Lung	HCC2279	6.8
Lung	HCC2935	7
Lung	HCC33	7.8
Lung	HCC366	6.5
Lung	HCC4006	6.9
Lung	HCC44	6.3
Lung	HCC78	6.8
Lung	HCC827	6.7
Lung	HCC95	6.3
Lung	HLC1	7
Lung	HLFA	6.3
Lung	HS229T	6.2
Lung	HS618T	6.1
Lung	IALM	6.1
Lung	KNS62	6
Lung	LC1F	6.6
Lung	LC1SQSF	6.5
Lung	LCLC103H	6.8
Lung	LCLC97TM1	6.9
Lung	LK2	7
Lung	LOUNH91	6.4
Lung	LU65	6.3
Lung	LU99	6.2
Lung	LUDLU1	6.3
Lung	LXF289	6.8
Lung	MORCPR	6.3
Lung	NCIH1048	7.1
Lung	NCIH1092	8.3
Lung	NCIH1105	8.7
Lung	NCIH1155	7
Lung	NCIH1184	7.3
Lung	NCIH1299	7
Lung	NCIH1339	6.8
Lung	NCIH1341	7.2
Lung	NCIH1355	6.3
Lung	NCIH1373	6.5
Lung	NCIH1385	6.4
Lung	NCIH1395	5
Lung	NCIH1435	7.3
Lung	NCIH1436	7.6
Lung	NCIH1437	5.9
Lung	NCIH146	7.8
Lung	NCIH1563	6.4
Lung	NCIH1568	6.7
Lung	NCIH1573	6.5
Lung	NCIH1581	7.7
Lung	NCIH1618	7.5
Lung	NCIH1623	5.7
Lung	NCIH1648	6.9
Lung	NCIH1650	6.7
Lung	NCIH1651	6.3
Lung	NCIH1666	6.4
Lung	NCIH1693	6.5
Lung	NCIH1694	7.2
Lung	NCIH1703	7.5
Lung	NCIH1734	7.1
Lung	NCIH1755	6.4
Lung	NCIH1781	7
Lung	NCIH1792	5.9
Lung	NCIH1793	5.8
Lung	NCIH1836	7.4
Lung	NCIH1838	5.8
Lung	NCIH1869	6.5
Lung	NCIH1876	8.5
Lung	NCIH1915	6.4
Lung	NCIH1930	6.9
Lung	NCIH1944	6.4
Lung	NCIH1963	7.1
Lung	NCIH196	6.9
Lung	NCIH1975	6.2
Lung	NCIH2009	6.9
Lung	NCIH2023	6.6
Lung	NCIH2029	8.1
Lung	NCIH2030	6.6
Lung	NCIH2066	7.2
Lung	NCIH2081	7.3
Lung	NCIH2085	6.6
Lung	NCIH2087	5.8
Lung	NCIH209	6.9
Lung	NCIH2106	7.7
Lung	NCIH2110	6.4
Lung	NCIH211	7.1
Lung	NCIH2122	5.9
Lung	NCIH2126	6.9
Lung	NCIH2141	7.9
Lung	NCIH2170	6.7
Lung	NCIH2171	7.4
Lung	NCIH2172	6.8
Lung	NCIH2196	6.5
Lung	NCIH2227	7.6
Lung	NCIH2228	6
Lung	NCIH226	6.7
Lung	NCIH2286	6.7
Lung	NCIH2291	5.9
Lung	NCIH2342	7
Lung	NCIH2347	5.6
Lung	NCIH23	6.4
Lung	NCIH2405	7.4
Lung	NCIH2444	6.4
Lung	NCIH292	6.7
Lung	NCIH322	5
Lung	NCIH3255	6.9
Lung	NCIH358	6.3
Lung	NCIH441	6
Lung	NCIH446	6.6
Lung	NCIH460	5.9
Lung	NCIH510	7
Lung	NCIH520	7
Lung	NCIH522	7.5
Lung	NCIH524	7.6
Lung	NCIH526	6.8
Lung	NCIH596	6.4
Lung	NCIH647	6.1
Lung	NCIH650	6.6
Lung	NCIH661	6.9
Lung	NCIH69	7.5
Lung	NCIH727	6.9
Lung	NCIH810	6.9
Lung	NCIH82	7.3
Lung	NCIH838	6.8
Lung	NCIH841	7.9
Lung	NCIH854	7.4
Lung	NCIH889	6.7
Lung	PC14	5.9
Lung	RERFLCAD1	6.7
Lung	RERFLCAD2	6.7
Lung	RERFLCAI	7
Lung	RERFLCKJ	6.9
Lung	RERFLCMS	6.4
Lung	RERFLCSQ1	6.9
Lung	SBC5	7.2
Lung	SCLC21H	7.3
Lung	SHP77	7.9
Lung	SKLU1	5.8
Lung	SKMES1	6.4
Lung	SQ1	5.1
Lung	SW1271	7
Lung	SW1573	7.4
Lung	SW900	6.3
Lung	VMRCLCD	7.3
Lung	VMRCLCP	6.8
Oesophagus	COLO680N	6.6
Oesophagus	ECGI10	6.6
Oesophagus	KYSE140	6.7
Oesophagus	KYSE150	6.8
Oesophagus	KYSE180	6.6
Oesophagus	KYSE270	6.4
Oesophagus	KYSE30	6.8
Oesophagus	KYSE410	6.8
Oesophagus	KYSE450	5.8
Oesophagus	KYSE510	6.6
Oesophagus	KYSE520	6
Oesophagus	KYSE70	6.4
Oesophagus	OE19	6.3
Oesophagus	OE33	6.8
Oesophagus	TE10	7.1
Oesophagus	TE11	6.3
Oesophagus	TE14	7.2
Oesophagus	TE15	6.7
Oesophagus	TE1	6.4
Oesophagus	TE4	7
Oesophagus	TE5	7
Oesophagus	TE6	6.4
Oesophagus	TE8	7
Oesophagus	TE9	6.5
Oesophagus	TT	6.5
Ovary	59M	7.1
Ovary	A2780	5.4
Ovary	CAOV3	5.5
Ovary	CAOV4	5.8
Ovary	COLO704	7.2
Ovary	COV318	6.5
Ovary	COV362	6.8
Ovary	COV434	7.4
Ovary	COV504	7.2
Ovary	COV644	7
Ovary	EFO21	6.3
Ovary	EFO27	6.3
Ovary	ES2	6.6
Ovary	FUOV1	6.7
Ovary	HEYA8	6.4
Ovary	HS571T	6
Ovary	IGROV1	6.5
Ovary	JHOC5	6.9
Ovary	JHOM1	7
Ovary	JHOM2B	7.7
Ovary	JHOS2	6.3
Ovary	JHOS4	5.4
Ovary	KURAMOCHI	7.5
Ovary	MCAS	5.7
Ovary	NIHOVCAR3	6.4
Ovary	OAW28	7.3
Ovary	OAW42	7
Ovary	OC314	7.5
Ovary	OC316	7.4
Ovary	ONCODG1	6.8
Ovary	OV56	6.4
Ovary	OV7	6.9
Ovary	OV90	6.9
Ovary	OVCAR4	6.6
Ovary	OVCAR8	6.7
Ovary	OVISE	5.7
Ovary	OVK18	7.2
Ovary	OVKATE	5.8
Ovary	OVMANA	6.9
Ovary	OVSAHO	5.8
Ovary	OVTOKO	5.5
Ovary	RMGI	5.3
Ovary	RMUGS	5.7
Ovary	SKOV3	6.9
Ovary	SNU119	6.8
Ovary	SNU840	6.5
Ovary	SNU8	7.2
Ovary	TOV112D	7.6
Ovary	TOV21G	7
Ovary	TYKNU	5.5
Pancreas	ASPC1	6.8
Pancreas	BXPC3	6.5
Pancreas	CAPAN1	6.4
Pancreas	CAPAN2	6.3
Pancreas	CFPAC1	6.2
Pancreas	DANG	6.4
Pancreas	HPAC	7.4
Pancreas	HPAFII	6.2
Pancreas	HS766T	6.1
Pancreas	HUPT3	5.7
Pancreas	HUPT4	6.9
Pancreas	KCIMOH1	6.8
Pancreas	KLM1	6.7
Pancreas	KP2	5.8
Pancreas	KP3	6.4
Pancreas	KP4	7.5
Pancreas	L33	6.6
Pancreas	MIAPACA2	3.7
Pancreas	PANC0203	6.4
Pancreas	PANC0213	7.1
Pancreas	PANC0327	6.3
Pancreas	PANC0403	5.9
Pancreas	PANC0504	6.6
Pancreas	PANC0813	6.5
Pancreas	PANC1005	5.9
Pancreas	PANC1	7.1
Pancreas	PATU8902	6.5
Pancreas	PATU8988S	6.9
Pancreas	PATU8988T	6.6
Pancreas	PK1	6
Pancreas	PK45H	6.9
Pancreas	PK59	6.6
Pancreas	PL45	6
Pancreas	PSN1	6.4
Pancreas	QGP1	7.1
Pancreas	SNU213	7
Pancreas	SNU324	6.5
Pancreas	SNU410	6.5
Pancreas	SU8686	7
Pancreas	SUIT2	5.6
Pancreas	SW1990	6
Pancreas	T3M4	6.3
Pancreas	TCCPAN2	5.8
Pancreas	YAPC	7.2
Pleura	ACCMESO1	6.5
Pleura	DM3	6.5
Pleura	ISTMES1	6.9
Pleura	ISTMES2	6.4
Pleura	JL1	6.9
Pleura	MPP89	6.7
Pleura	MSTO211H	6
Pleura	NCIH2052	5.5
Pleura	NCIH2452	7.1
Pleura	NCIH28	6.7
Prostate	22RV1	6.9
Prostate	DU145	5.8
Prostate	LNCAPCLONEFGC	6.7
Prostate	MDAPCA2B	6.9
Prostate	NCIH660	7.2
Prostate	PC3	6.1
Prostate	VCAP	7
Salivary gland	A253	7.1
Salivary gland	YD15	6.5
Skin	A101D	6.2
Skin	A2058	6.9
Skin	A375	6.4
Skin	C32	6.7
Skin	CHL1	6.4
Skin	CJM	6.6
Skin	COLO679	6.6
Skin	COLO741	7.2
Skin	COLO783	6.8
Skin	COLO792	6.7
Skin	COLO800	6.9
Skin	COLO818	6.9
Skin	COLO829	6.8
Skin	COLO849	7.4
Skin	G361	6.5
Skin	GRM	6.9
Skin	HMCB	6.8
Skin	HS294T	6
Skin	HS600T	6.1
Skin	HS688AT	6.7
Skin	HS695T	6.3
Skin	HS839T	6.4
Skin	HS852T	6.4
Skin	HS895T	5.8
Skin	HS934T	6.7
Skin	HS936T	7.3
Skin	HS939T	6.1
Skin	HS940T	6.2
Skin	HS944T	6.2
Skin	HT144	6.4
Skin	IGR1	6.8
Skin	IGR37	6.9
Skin	IGR39	6.4
Skin	IPC298	6.7
Skin	K029AX	7
Skin	LOXIMVI	7
Skin	MALME3M	6.6
Skin	MDAMB435S	6.4
Skin	MELHO	7.5
Skin	MELJUSO	6.7
Skin	MEWO	7.4
Skin	RPMI7951	6.9
Skin	RVH421	6.6
Skin	SH4	5.8
Skin	SKMEL1	6.6
Skin	SKMEL24	6.6
Skin	SKMEL28	7
Skin	SKMEL2	7
Skin	SKMEL30	6.8
Skin	SKMEL31	6.8
Skin	SKMEL3	6.6
Skin	SKMEL5	6.5
Skin	UACC257	6.3
Skin	UACC62	6.5
Skin	WM115	6.9
Skin	WM1799	6.8
Skin	WM2664	7.4
Skin	WM793	7
Skin	WM88	6.8
Skin	WM983B	6.8
Small intestine	HUTU80	7.6
Soft tissue	A204	7.3
Soft tissue	G401	7
Soft tissue	G402	6.8
Soft tissue	GCT	7.2
Soft tissue	HS729	7.2
Soft tissue	HT1080	6.6
Soft tissue	KYM1	7.5
Soft tissue	MESSA	4.2
Soft tissue	RD	7.7
Soft tissue	RH30	6.9
Soft tissue	RH41	7.2
Soft tissue	RKN	6.4
Soft tissue	S117	7.4
Soft tissue	SJRH30	6.8
Soft tissue	SKLMS1	7
Soft tissue	SKUT1	6.9
Soft tissue	TE125T	6.4
Soft tissue	TE159T	6.6
Soft tissue	TE441T	7.5
Soft tissue	TE617T	7.3
Stomach	2313287	7.5
Stomach	AGS	7.2
Stomach	AZ521	7.8
Stomach	ECC10	8
Stomach	ECC12	7.8
Stomach	FU97	6.4
Stomach	GCIY	6.5
Stomach	GSS	8
Stomach	GSU	7.1
Stomach	HGC27	6.5
Stomach	HS746T	7
Stomach	HUG1N	7.1
Stomach	IM95	6.7
Stomach	KATOIII	6.7
Stomach	KE39	6.7
Stomach	LMSU	6.7
Stomach	MKN1	6.9
Stomach	MKN45	6.7
Stomach	MKN74	7.2
Stomach	MKN7	6.8
Stomach	NCCSTCK140	7.4
Stomach	NCIN87	7
Stomach	NUGC2	7
Stomach	NUGC3	6.7
Stomach	NUGC4	6.8
Stomach	OCUM1	6.6
Stomach	RERFGC1B	7.4
Stomach	SH10TC	6.5
Stomach	SNU16	7.1
Stomach	SNU1	6.1
Stomach	SNU216	6.8
Stomach	SNU520	7.7
Stomach	SNU5	5.5
Stomach	SNU601	7.2
Stomach	SNU620	7.1
Stomach	SNU668	7.1
Stomach	SNU719	7
Stomach	TGBC11TKB	7.7
Thyroid	8305C	6.6
Thyroid	8505C	6.8
Thyroid	BCPAP	6.9
Thyroid	BHT101	6.9
Thyroid	CAL62	6.7
Thyroid	CGTHW1	6.7
Thyroid	FTC133	7
Thyroid	FTC238	7.5
Thyroid	ML1	6.6
Thyroid	SW579	6.5
Thyroid	TT2609C02	6.9
Thyroid	TT	7.9
Upper aerodigestive tract	BHY	5.6
Upper aerodigestive tract	BICR16	6
Upper aerodigestive tract	BICR18	6.5
Upper aerodigestive tract	BICR22	7
Upper aerodigestive tract	BICR31	6.9
Upper aerodigestive tract	BICR56	7.1
Upper aerodigestive tract	BICR6	6.6
Upper aerodigestive tract	CAL27	6.7
Upper aerodigestive tract	CAL33	7
Upper aerodigestive tract	DETROIT562	6.6
Upper aerodigestive tract	FADU	6.8
Upper aerodigestive tract	HS840T	6.3
Upper aerodigestive tract	HSC2	6.4
Upper aerodigestive tract	HSC3	5.9
Upper aerodigestive tract	HSC4	7.1
Upper aerodigestive tract	PECAPJ15	6.6
Upper aerodigestive tract	PECAPJ34CLONEC12	6.7
Upper aerodigestive tract	PECAPJ41CLONED2	6.7
Upper aerodigestive tract	PECAPJ49	6.6
Upper aerodigestive tract	SCC15	6.5
Upper aerodigestive tract	SCC25	6.9
Upper aerodigestive tract	SCC4	6.6
Upper aerodigestive tract	SCC9	6.8
Upper aerodigestive tract	SNU1076	6.4
Upper aerodigestive tract	SNU1214	6.9
Upper aerodigestive tract	SNU46	6.8
Upper aerodigestive tract	SNU899	6.3
Upper aerodigestive tract	YD10B	6.9
Upper aerodigestive tract	YD38	6.8
Upper aerodigestive tract	YD8	7.1
Urinary tract	5637	6.7
Urinary tract	639V	7
Urinary tract	647V	7
Urinary tract	BC3C	6.6
Urinary tract	BFTC905	6.6
Urinary tract	CAL29	7.1
Urinary tract	HS172T	6.4
Urinary tract	HT1197	6.7
Urinary tract	HT1376	6.8
Urinary tract	J82	6.7
Urinary tract	JMSU1	7.7
Urinary tract	KMBC2	6.7
Urinary tract	KU1919	6.7
Urinary tract	RT11284	7.1
Urinary tract	RT112	6.4
Urinary tract	RT4	7.1
Urinary tract	SCABER	6.5
Urinary tract	SW1710	6.9
Urinary tract	SW780	6.9
Urinary tract	T24	6.5
Urinary tract	TCCSUP	6.9
Urinary tract	UMUC1	7
Urinary tract	UMUC3	7.3
Urinary tract	VMCUB1	6.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	17.7
Adrenal gland	14.4
Appendix	17.7
Bone marrow	11
Breast	18.3
Cerebral cortex	21.5
Cervix, uterine	30.1
Colon	13
Duodenum	13.9
Endometrium	29.5
Epididymis	15.5
Esophagus	21
Fallopian tube	32.9
Gallbladder	25.6
Heart muscle	10.9
Kidney	12.8
Liver	4.8
Lung	22.1
Lymph node	22.5
Ovary	36.5
Pancreas	4.1
Parathyroid gland	75.6
Placenta	18.3
Prostate	23.7
Rectum	14.7
Salivary gland	10.1
Seminal vesicle	21
Skeletal muscle	9.9
Skin	34
Small intestine	16.8
Smooth muscle	27.7
Spleen	25
Stomach	12.5
Testis	17
Thyroid gland	40.8
Tonsil	18.8
Urinary bladder	22.7

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27195705	altered expression	Breast Carcinoma	However, only MYC, DNAH5, CSFR1, EPHA7, ARID1B, and KMT2C preserved an independent prognosis impact and/or showed a significantly different incidence of alterations between relapsed and non-relapsed cases in the TCGA series
26345631	loss of expression	Non-Small Cell Lung Carcinoma	The loss of the expression of ARID1A, ARID1B, and BAF47 was observed only in a fraction of NSCLC cases.
25817822	overexpression	Breast Carcinoma	Univariate analysis revealed that high ARID1B expression is correlated closely with histological grade (P = 0.045) and size (P = 0.043) of invasive breast cancer.
24366360	loss of expression (copy number loss)	Waldenstrom Macroglobulinemia	Validated gene losses due to CNAs involved PRDM2 (93%), BTG1 (87%), HIVEP2 (77%), MKLN1 (77%), PLEKHG1 (70%), LYN (60%), ARID1B (50%), and FOXP1 (37%). Losses in PLEKHG1, HIVEP2, ARID1B, and BCLAF1 constituted the most common deletions within chromosome 6.
23660946	underexpression	Pancreatic Carcinoma	In addition, ARID1B exhibited significantly reduced/loss of expression in PaCa tissue, especially in samples from advanced-stage tumours, when compared with normal pancreas.
26637902	underexpression	Gastric Carcinoma	Low expression rates of ARID1A, 1B, and 2 in gastric carcinoma were 20%, 10%, and 15% respectively. Loss of ARID1B and ARID2 was also related to tumor progression, but their relationship was weaker than that of ARID1A.
27562491	loss of expression	Endometrioid Carcinoma; Ovarian Dedifferentiated Carcinoma	ARID1B expression was absent in the undifferentiated component in all 12 tumours, whereas the corresponding endometrioid component showed intact expression.

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.414	3.34e-18	46.8	45.5	7.7	Loss
BRCA	Breast invasive carcinoma	1075	0.482	1.6e-63	33.8	53.3	12.9	Loss
CESC	Cervical and endocervical cancers	292	0.524	5.61e-22	33.2	59.6	7.2	Neutral
COAD	Colon adenocarcinoma	449	0.32	3.82e-12	12.2	71.7	16	Neutral
ESCA	Esophageal carcinoma	183	0.432	1.03e-09	28.4	51.9	19.7	Neutral
GBM	Glioblastoma multiforme	147	0.441	2.2e-08	34	62.6	3.4	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.349	3.47e-16	17.5	71.4	11.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.474	8.04e-31	28.4	70.1	1.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.205	0.000451	11.1	87.2	1.7	Neutral
LAML	Acute Myeloid Leukemia	166	-0.021	0.791	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.45	6.04e-27	16.2	82.8	1	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.439	1.4e-18	38.2	50.3	11.5	Loss
LUAD	Lung adenocarcinoma	512	0.383	2.33e-19	50.6	41.2	8.2	Loss
LUSC	Lung squamous cell carcinoma	498	0.401	1.09e-20	25.9	54.6	19.5	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.685	6.39e-43	63.3	22	14.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.391	7.21e-08	48.6	49.2	2.3	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.505	7.45e-12	12.3	83.3	4.3	Neutral
PRAD	Prostate adenocarcinoma	491	0.123	0.00641	11	87.8	1.2	Neutral
READ	Rectum adenocarcinoma	164	0.562	5.1e-15	17.1	62.2	20.7	Neutral
SARC	Sarcoma	255	0.295	1.63e-06	18.8	56.5	24.7	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.477	3.22e-22	61.6	33	5.4	Loss
STAD	Stomach adenocarcinoma	413	0.464	1.84e-23	21.3	63	15.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.354	8.76e-06	16.7	68.7	14.7	Neutral
THCA	Thyroid carcinoma	497	0.063	0.161	1.2	98.4	0.4	Neutral
THYM	Thymoma	119	0.221	0.0159	18.5	81.5	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.283	2.32e-11	8.2	79.3	12.5	Neutral

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.256	9.17e-08	17	408	0.005	0.183	NS/NA
BRCA	Breast invasive carcinoma	-0.34	0	83	785	0.003	5.55e-19	NS/NA
CESC	Cervical and endocervical cancers	-0.397	5.72e-13	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.258	3.59e-06	19	297	0.006	0.000838	NS/NA
ESCA	Esophageal carcinoma	-0.352	5.79e-07	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.338	0.00613	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.349	6.31e-17	20	522	0.002	0.00286	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.308	6.67e-09	24	319	0.009	5.23e-10	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.419	2.74e-14	23	275	0.011	2.21e-09	NS/NA
LAML	Acute Myeloid Leukemia	-0.044	0.571	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.252	4.88e-09	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.414	0	41	373	0.015	2.95e-15	NS/NA
LUAD	Lung adenocarcinoma	-0.186	4.62e-05	21	456	0.015	0.656	NS/NA
LUSC	Lung squamous cell carcinoma	-0.209	4.5e-05	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.55	0.133	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.368	3.73e-07	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.319	9.65e-06	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.316	9.87e-14	35	498	0.003	0.000411	NS/NA
READ	Rectum adenocarcinoma	-0.199	0.0465	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.224	0.000253	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.352	4.34e-15	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.322	2.61e-10	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.192	0.0162	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.051	0.233	50	509	-0.001	0.905	NS/NA
THYM	Thymoma	-0.153	0.0916	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.131	0.0047	34	431	0.013	2.17e-16	NS/NA

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	1	Low
Bone marrow	3	High
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	3	High
Esophagus	3	High
Fallopian tube	2	Medium
Gallbladder	3	High
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	1	Low
Oral mucosa	3	High
Ovary	1	Low
Pancreas	2	Medium
Parathyroid gland	3	High
Placenta	2	Medium
Prostate	1	Low
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	3	High
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.692	NS	24476821
BRCA	Breast invasive carcinoma	521	0.0746	NS	23000897
COAD	Colon adenocarcinoma	149	0.018	Significant	22810696
GBM	Glioblastoma multiforme	157	0.000235	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000149	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.884	NS	26536169
LGG	Brain Lower Grade Glioma	513	4.79e-11	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0426	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0167	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0927	NS	21720365
PRAD	Prostate adenocarcinoma	333	1.74e-07	Significant	26544944
READ	Rectum adenocarcinoma	67	0.23	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00217	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.0426	Significant	25079317
THCA	Thyroid carcinoma	391	0.012	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.706	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.9	0.619	NS
BRCA	Breast invasive carcinoma	1079	1.817	0.00987	Shorter
CESC	Cervical and endocervical cancers	291	1.548	0.182	NS
COAD	Colon adenocarcinoma	439	1.134	0.67	NS
ESCA	Esophageal carcinoma	184	0.584	0.102	NS
GBM	Glioblastoma multiforme	158	0.839	0.504	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.646	0.0197	Longer
KIRC	Kidney renal clear cell carcinoma	531	0.518	0.00507	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.185	0.726	NS
LAML	Acute Myeloid Leukemia	149	0.722	0.27	NS
LGG	Brain Lower Grade Glioma	511	0.552	0.0116	Longer
LIHC	Liver hepatocellular carcinoma	365	1.295	0.33	NS
LUAD	Lung adenocarcinoma	502	1.026	0.902	NS
LUSC	Lung squamous cell carcinoma	494	1.048	0.815	NS
OV	Ovarian serous cystadenocarcinoma	303	1.648	0.0204	Shorter
PAAD	Pancreatic adenocarcinoma	177	0.911	0.766	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.043	0.976	NS
PRAD	Prostate adenocarcinoma	497	0	0.104	NS
READ	Rectum adenocarcinoma	159	0.754	0.605	NS
SARC	Sarcoma	259	1.432	0.208	NS
SKCM	Skin Cutaneous Melanoma	459	1.291	0.195	NS
STAD	Stomach adenocarcinoma	388	0.792	0.302	NS
TGCT	Testicular Germ Cell Tumors	134	1.095	0.949	NS
THCA	Thyroid carcinoma	500	1.478	0.667	NS
THYM	Thymoma	119	0.812	0.802	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.23	0.478	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.177	0.000339	Lower
BRCA	Breast invasive carcinoma	1071	-0.024	0.425	NS
CESC	Cervical and endocervical cancers	167	0.033	0.672	NS
COAD	Colon adenocarcinoma	445	-0.002	0.962	NS
ESCA	Esophageal carcinoma	162	-0.057	0.47	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.043	0.358	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.208	1.4e-06	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.037	0.548	NS
LIHC	Liver hepatocellular carcinoma	347	0.034	0.529	NS
LUAD	Lung adenocarcinoma	507	0.045	0.307	NS
LUSC	Lung squamous cell carcinoma	497	0.03	0.506	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.026	0.658	NS
PAAD	Pancreatic adenocarcinoma	176	0.068	0.368	NS
READ	Rectum adenocarcinoma	156	0.021	0.798	NS
SKCM	Skin Cutaneous Melanoma	410	-0.126	0.0106	Lower
STAD	Stomach adenocarcinoma	392	-0.041	0.423	NS
TGCT	Testicular Germ Cell Tumors	81	-0.094	0.405	NS
THCA	Thyroid carcinoma	499	-0.045	0.317	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.051	0.253	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.094	0.121	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.02	0.658	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.198	4.88e-06	Lower
LGG	Brain Lower Grade Glioma	514	-0.018	0.692	NS
LIHC	Liver hepatocellular carcinoma	366	-0.063	0.232	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.03	0.613	NS
PAAD	Pancreatic adenocarcinoma	176	-0.005	0.947	NS
STAD	Stomach adenocarcinoma	406	-0.076	0.127	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.044	0.315	NS

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

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Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

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There is no record for ARID1B.

Summary
Symbol	ARID1B
Name	AT-rich interaction domain 1B
Aliases	KIAA1235; ELD/OSA1; p250R; BAF250b; DAN15; 6A3-5; MRD12; OSA2; ARID domain-containing protein 1B; BRG1-assoc ......
Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26892443	Spitzoid Melanoma	partner	SNX9	Fusion	In addition, two tumors each contained a second fusion gene, ARID1B-SNX9 or PTPRZ1-NFAM1.
27392123	Leukemia	partner	ZNF384	Fusion	Seven of the 240 patients were identified to have ZNF384 gene rearrangements including partner genes TCF3 (four patients), EWSR1 (one patient), EP300 (one patient), and the novel gene partner ARID1B (one patient).
27723760	Schwannoma	downstream	p16(INK4a); p21(CIP1a); p53	regulation	ARID1B controls p16(INK4a) and p21(CIP1a) transcription but also regulates DNA damage, oxidative stress, and p53 induction, suggesting that SWI/SNF uses additional mechanisms to regulate senescence.