Browse ASH1L in pancancer

Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF01426 BAH domain
PF00439 Bromodomain
PF00856 SET domain
Function

Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).

Classification
Class Modification Substrate Product PubMed
Histone modification write Histone methylation H3K36 H3K36me 21239497
> Gene Ontology
 
Biological Process GO:0001933 negative regulation of protein phosphorylation
GO:0002526 acute inflammatory response
GO:0002673 regulation of acute inflammatory response
GO:0002674 negative regulation of acute inflammatory response
GO:0006323 DNA packaging
GO:0006479 protein methylation
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008213 protein alkylation
GO:0010452 histone H3-K36 methylation
GO:0016570 histone modification
GO:0016571 histone methylation
GO:0018022 peptidyl-lysine methylation
GO:0018027 peptidyl-lysine dimethylation
GO:0018205 peptidyl-lysine modification
GO:0031348 negative regulation of defense response
GO:0032102 negative regulation of response to external stimulus
GO:0032259 methylation
GO:0032635 interleukin-6 production
GO:0034968 histone lysine methylation
GO:0042326 negative regulation of phosphorylation
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043409 negative regulation of MAPK cascade
GO:0043414 macromolecule methylation
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0051568 histone H3-K4 methylation
GO:0071103 DNA conformation change
GO:0097676 histone H3-K36 dimethylation
GO:1902532 negative regulation of intracellular signal transduction
Molecular Function GO:0003682 chromatin binding
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016278 lysine N-methyltransferase activity
GO:0016279 protein-lysine N-methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
GO:0018024 histone-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0046975 histone methyltransferase activity (H3-K36 specific)
Cellular Component GO:0005923 bicellular tight junction
GO:0043296 apical junction complex
GO:0070160 occluding junction
> KEGG and Reactome Pathway
 
KEGG hsa00310 Lysine degradation
Reactome R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-3214841: PKMTs methylate histone lysines
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
COSMIC ID CDS change AA change Mutation Type Anatomical Site
COSM896951c.229G>Tp.E77*Substitution - NonsenseEndometrium
COSM2210748c.1313C>Tp.A438VSubstitution - MissenseLarge_intestine
COSM1334661c.3620A>Cp.N1207TSubstitution - MissenseLarge_intestine
COSM3474963c.5013C>Tp.S1671SSubstitution - coding silentSkin
COSM3474977c.2096G>Ap.S699NSubstitution - MissenseSkin
COSM170344c.6217C>Tp.R2073CSubstitution - MissenseLarge_intestine
COSM675756c.5809G>Ap.E1937KSubstitution - MissenseLung
COSM5491205c.398A>Gp.N133SSubstitution - MissenseBiliary_tract
COSM896942c.1607G>Ap.G536DSubstitution - MissenseEndometrium
COSM675758c.6221C>Gp.S2074*Substitution - NonsenseLung
COSM4604798c.2294G>Cp.G765ASubstitution - MissenseUpper_aerodigestive_tract
COSM1600921c.8660A>Cp.N2887TSubstitution - MissenseLiver
COSM5606329c.155G>Ap.R52QSubstitution - MissenseSkin
COSM896914c.6698G>Ap.G2233ESubstitution - MissenseEndometrium
COSM5218870c.2134_2135insAp.R712fs*10Insertion - FrameshiftBreast
COSM3376751c.5585T>Cp.V1862ASubstitution - MissensePancreas
COSM5961423c.2616delTp.I872fs*26Deletion - FrameshiftAdrenal_gland
COSM5052621c.8189G>Ap.R2730QSubstitution - MissenseStomach
COSM347929c.8888G>Ap.R2963QSubstitution - MissenseLung
COSM5985140c.5843C>Gp.P1948RSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3788785c.7552G>Ap.E2518KSubstitution - MissenseUrinary_tract
COSM4023039c.7523C>Tp.A2508VSubstitution - MissenseStomach
COSM896904c.8163C>Tp.H2721HSubstitution - coding silentEndometrium
COSM4605012c.2887G>Cp.E963QSubstitution - MissenseUpper_aerodigestive_tract
COSM372098c.8634G>Tp.E2878DSubstitution - MissenseLung
COSM5418620c.4030C>Gp.P1344ASubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM347929c.8888G>Ap.R2963QSubstitution - MissenseLung
COSM896917c.6339C>Ap.I2113ISubstitution - coding silentEndometrium
COSM3385240c.2728G>Ap.V910MSubstitution - MissensePancreas
COSM896900c.8887C>Tp.R2963*Substitution - NonsenseEndometrium
COSM1185614c.1921A>Gp.I641VSubstitution - MissenseLung
COSM896930c.3645G>Tp.E1215DSubstitution - MissenseEndometrium
COSM136172c.1727C>Tp.S576LSubstitution - MissenseSkin
COSM3705046c.8120+8C>Tp.?UnknownLiver
COSM4023040c.7350T>Cp.G2450GSubstitution - coding silentStomach
COSM5565420c.8731C>Tp.R2911*Substitution - NonsenseProstate
COSM3740694c.7804-5T>Cp.?UnknownLiver
COSM3705050c.5712A>Gp.V1904VSubstitution - coding silentLiver
COSM1134718c.8633A>Gp.E2878GSubstitution - MissenseKidney
COSM4023052c.4165T>Gp.S1389ASubstitution - MissenseStomach
COSM4912989c.4547G>Cp.R1516PSubstitution - MissenseLiver
COSM4403759c.3080C>Tp.A1027VSubstitution - MissenseSkin
COSM4023057c.3388C>Tp.P1130SSubstitution - MissenseStomach
COSM5025373c.5325C>Tp.C1775CSubstitution - coding silentBreast
COSM98266c.2771C>Gp.S924CSubstitution - MissenseLung
COSM170344c.6217C>Tp.R2073CSubstitution - MissenseLarge_intestine
COSM1183762c.7262G>Ap.R2421QSubstitution - MissenseLarge_intestine
COSM110297c.1152C>Ap.A384ASubstitution - coding silentSkin
COSM5377846c.3490C>Tp.P1164SSubstitution - MissenseSkin
COSM896903c.8185C>Tp.R2729CSubstitution - MissenseEndometrium
COSM5881527c.8638G>Ap.E2880KSubstitution - MissenseBreast
COSM896940c.2213G>Tp.R738ISubstitution - MissenseEndometrium
COSM1235963c.5800G>Cp.E1934QSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM4605421c.4603C>Tp.R1535CSubstitution - MissenseUpper_aerodigestive_tract
COSM896900c.8887C>Tp.R2963*Substitution - NonsenseLarge_intestine
COSM896946c.523T>Cp.S175PSubstitution - MissenseEndometrium
COSM896916c.6410A>Gp.E2137GSubstitution - MissenseEndometrium
COSM265394c.5380_5382delCATp.H1794delHDeletion - In frameLarge_intestine
COSM4851899c.3347G>Cp.G1116ASubstitution - MissenseCervix
COSM1134720c.3443C>Tp.T1148ISubstitution - MissenseKidney
COSM4643557c.3459G>Tp.K1153NSubstitution - MissenseLarge_intestine
COSM270810c.3478C>Tp.R1160WSubstitution - MissenseLarge_intestine
COSM4170547c.5438A>Gp.Y1813CSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM175033c.2951G>Ap.R984HSubstitution - MissenseLarge_intestine
COSM896937c.2491C>Tp.P831SSubstitution - MissenseEndometrium
COSM675749c.3326C>Ap.S1109YSubstitution - MissenseLung
COSM4663700c.5697T>Cp.A1899ASubstitution - coding silentLarge_intestine
COSM1193141c.3814C>Tp.R1272WSubstitution - MissenseLung
COSM1127360c.4403G>Tp.S1468ISubstitution - MissenseProstate
COSM4023036c.8580A>Gp.E2860ESubstitution - coding silentStomach
COSM1179212c.4708G>Tp.G1570*Substitution - NonsenseProstate
COSM3474952c.8158C>Tp.P2720SSubstitution - MissenseSkin
COSM1334664c.3038A>Cp.K1013TSubstitution - MissenseLarge_intestine
COSM4763010c.865A>Gp.K289ESubstitution - MissenseStomach
COSM4023068c.1243G>Tp.G415CSubstitution - MissenseStomach
COSM3984295c.7178A>Gp.N2393SSubstitution - MissenseKidney
COSM5930176c.8620C>Gp.P2874ASubstitution - MissenseSkin
COSM5813498c.6902A>Tp.H2301LSubstitution - MissenseLiver
COSM4900659c.7373C>Tp.S2458FSubstitution - MissenseSkin
COSM4763008c.1504C>Gp.Q502ESubstitution - MissenseStomach
COSM5676981c.4554A>Gp.R1518RSubstitution - coding silentSoft_tissue
COSM212164c.4068G>Tp.M1356ISubstitution - MissenseBreast
COSM3474955c.7091G>Ap.R2364QSubstitution - MissenseSkin
COSM896902c.8500C>Tp.R2834*Substitution - NonsenseLarge_intestine
COSM4605873c.7490C>Gp.T2497SSubstitution - MissenseUpper_aerodigestive_tract
COSM5496033c.3736G>Cp.E1246QSubstitution - MissenseBiliary_tract
COSM3474969c.3909C>Tp.I1303ISubstitution - coding silentSkin
COSM4932737c.1638A>Gp.P546PSubstitution - coding silentLiver
COSM5520091c.8272G>Ap.D2758NSubstitution - MissenseBiliary_tract
COSM4023050c.4554A>Cp.R1518SSubstitution - MissenseStomach
COSM896909c.6943C>Tp.H2315YSubstitution - MissenseEndometrium
COSM896923c.4497G>Ap.Q1499QSubstitution - coding silentEndometrium
COSM4023066c.1580G>Ap.C527YSubstitution - MissenseStomach
COSM4663692c.8852G>Ap.R2951QSubstitution - MissenseLarge_intestine
COSM5813519c.3249A>Tp.S1083SSubstitution - coding silentLiver
COSM896901c.8804-1G>Tp.?UnknownEndometrium
COSM4798149c.4969G>Ap.V1657ISubstitution - MissenseLiver
COSM4663696c.8410T>Ap.Y2804NSubstitution - MissenseLarge_intestine
COSM3802116c.1985T>Cp.I662TSubstitution - MissenseBreast
COSM4023063c.2173A>Gp.R725GSubstitution - MissenseStomach
COSM4567255c.6246_6247CC>TTp.L2083FSubstitution - MissenseSkin
COSM4472492c.1787C>Tp.S596FSubstitution - MissenseSkin
COSM5432664c.6735G>Tp.M2245ISubstitution - MissenseOesophagus
COSM1245562c.1589C>Tp.P530LSubstitution - MissenseOesophagus
COSM5341583c.6767A>Cp.N2256TSubstitution - MissenseLarge_intestine
COSM170344c.6217C>Tp.R2073CSubstitution - MissenseSkin
COSM4796206c.5042G>Ap.S1681NSubstitution - MissenseLiver
COSM1334667c.1624A>Gp.T542ASubstitution - MissenseLarge_intestine
COSM4945376c.5780A>Cp.K1927TSubstitution - MissenseLiver
COSM5052623c.4992G>Ap.Q1664QSubstitution - coding silentStomach
COSM463104c.8523C>Gp.R2841RSubstitution - coding silentKidney
COSM107335c.8578G>Ap.E2860KSubstitution - MissenseSkin
COSM3355896c.4999T>Cp.S1667PSubstitution - MissenseBreast
COSM3474960c.6300C>Tp.T2100TSubstitution - coding silentSkin
COSM5002458c.2859G>Tp.R953SSubstitution - MissensePancreas
COSM3979875c.2092G>Ap.E698KSubstitution - MissenseOvary
COSM5477643c.854A>Cp.K285TSubstitution - MissenseLarge_intestine
COSM3979874c.6383G>Ap.C2128YSubstitution - MissenseOvary
COSM2210629c.8174A>Gp.H2725RSubstitution - MissenseLarge_intestine
COSM3976197c.4291C>Tp.H1431YSubstitution - MissenseLung
COSM3862917c.4760C>Tp.S1587FSubstitution - MissenseSkin
COSM1626486c.988A>Gp.T330ASubstitution - MissenseLiver
COSM2210758c.576G>Ap.T192TSubstitution - coding silentLarge_intestine
COSM1334671c.74C>Tp.A25VSubstitution - MissenseLarge_intestine
COSM2210623c.8547G>Cp.L2849FSubstitution - MissenseUpper_aerodigestive_tract
COSM896902c.8500C>Tp.R2834*Substitution - NonsenseEndometrium
COSM1238240c.8735G>Ap.R2912QSubstitution - MissenseOesophagus
COSM3474973c.2627C>Tp.S876FSubstitution - MissenseSkin
COSM4655531c.2749G>Ap.E917KSubstitution - MissenseLarge_intestine
COSM896939c.2264C>Ap.S755YSubstitution - MissenseEndometrium
COSM3474978c.1744C>Tp.P582SSubstitution - MissenseSkin
COSM3474980c.1235C>Ap.P412HSubstitution - MissenseSkin
COSM896920c.5293C>Ap.L1765ISubstitution - MissenseEndometrium
COSM5352966c.7745G>Ap.R2582HSubstitution - MissenseLarge_intestine
COSM172621c.6436C>Tp.R2146*Substitution - NonsenseLarge_intestine
COSM272358c.8258C>Tp.T2753ISubstitution - MissenseLarge_intestine
COSM3934124c.2818G>Cp.D940HSubstitution - MissenseOesophagus
COSM675760c.7655T>Cp.I2552TSubstitution - MissenseLung
COSM4023043c.6464G>Ap.R2155KSubstitution - MissenseStomach
COSM5605550c.1634C>Tp.S545FSubstitution - MissenseSkin
COSM136171c.6367C>Tp.P2123SSubstitution - MissenseSkin
COSM3984297c.1242A>Gp.A414ASubstitution - coding silentKidney
COSM5505697c.2954A>Gp.K985RSubstitution - MissenseBiliary_tract
COSM1334660c.3665delAp.K1222fs*11Deletion - FrameshiftLarge_intestine
COSM5558699c.4923A>Cp.L1641LSubstitution - coding silentProstate
COSM30720c.46G>Ap.E16KSubstitution - MissensePancreas
COSM1600923c.4224_4225delTTp.Y1409fs*32Deletion - FrameshiftLiver
COSM392336c.8683_8684insAp.T2895fs*5Insertion - FrameshiftSkin
COSM256354c.2972C>Ap.T991NSubstitution - MissenseLarge_intestine
COSM896912c.6790A>Gp.K2264ESubstitution - MissenseEndometrium
COSM256355c.2598A>Gp.P866PSubstitution - coding silentLarge_intestine
COSM5624108c.6232G>Cp.V2078LSubstitution - MissenseOesophagus
COSM2210699c.4411C>Tp.P1471SSubstitution - MissenseSkin
COSM170344c.6217C>Tp.R2073CSubstitution - MissenseSkin
COSM230883c.4927C>Tp.R1643WSubstitution - MissenseSkin
COSM1334660c.3665delAp.K1222fs*11Deletion - FrameshiftLarge_intestine
COSM424064c.1475A>Cp.K492TSubstitution - MissenseBreast
COSM1742809c.363A>Cp.K121NSubstitution - MissenseBiliary_tract
COSM1334666c.2134delAp.R712fs*23Deletion - FrameshiftLarge_intestine
COSM110503c.3557C>Tp.S1186FSubstitution - MissenseSkin
COSM5648132c.2346G>Cp.L782FSubstitution - MissenseOesophagus
COSM222571c.3874G>Tp.E1292*Substitution - NonsenseSkin
COSM4421415c.6173A>Gp.N2058SSubstitution - MissensePleura
COSM133967c.5806G>Ap.E1936KSubstitution - MissenseSkin
COSM1295174c.8023G>Ap.D2675NSubstitution - MissenseUrinary_tract
COSM4982135c.4616C>Tp.S1539FSubstitution - MissenseOesophagus
COSM1334660c.3665delAp.K1222fs*11Deletion - FrameshiftLarge_intestine
COSM2210714c.3838C>Tp.R1280*Substitution - NonsenseBreast
COSM1134721c.294A>Gp.K98KSubstitution - coding silentKidney
COSM4651965c.5478C>Tp.V1826VSubstitution - coding silentLarge_intestine
COSM1127358c.681T>Ap.C227*Substitution - NonsenseProstate
COSM206743c.7567C>Tp.R2523CSubstitution - MissenseEndometrium
COSM4840946c.6762T>Gp.D2254ESubstitution - MissenseCervix
COSM5806815c.3448G>Tp.A1150SSubstitution - MissenseLiver
COSM3667363c.4091C>Tp.P1364LSubstitution - MissenseLiver
COSM1334659c.3760C>Tp.R1254CSubstitution - MissenseLarge_intestine
COSM4023065c.1688C>Gp.S563CSubstitution - MissenseStomach
COSM1472717c.5070G>Cp.E1690DSubstitution - MissenseBreast
COSM3862920c.4000C>Tp.P1334SSubstitution - MissenseSkin
COSM137785c.5985T>Ap.Y1995*Substitution - NonsenseSkin
COSM424063c.2264C>Gp.S755CSubstitution - MissenseBreast
COSM3474957c.6717C>Tp.L2239LSubstitution - coding silentSkin
COSM1193141c.3814C>Tp.R1272WSubstitution - MissenseLarge_intestine
COSM317025c.7699G>Ap.V2567ISubstitution - MissenseLung
COSM3667363c.4091C>Tp.P1364LSubstitution - MissenseLiver
COSM3369319c.8713A>Gp.T2905ASubstitution - MissenseThyroid
COSM4839420c.5169A>Cp.Q1723HSubstitution - MissenseCervix
COSM3705049c.5992G>Ap.V1998ISubstitution - MissenseLiver
COSM373515c.8748G>Tp.R2916RSubstitution - coding silentLung
COSM1747801c.3809G>Ap.R1270QSubstitution - MissenseLarge_intestine
COSM4023067c.1323T>Cp.S441SSubstitution - coding silentStomach
COSM896947c.471C>Tp.C157CSubstitution - coding silentEndometrium
COSM3369320c.298C>Tp.P100SSubstitution - MissenseThyroid
COSM5547887c.5829-8delCp.?UnknownProstate
COSM4827043c.7416G>Ap.K2472KSubstitution - coding silentCervix
COSM4603894c.7891-5delAp.?UnknownUpper_aerodigestive_tract
COSM4663701c.4871G>Ap.R1624QSubstitution - MissenseLarge_intestine
COSM3474959c.6477C>Tp.P2159PSubstitution - coding silentSkin
COSM463105c.8119A>Gp.K2707ESubstitution - MissenseKidney
COSM5658996c.6959G>Ap.R2320KSubstitution - MissenseSoft_tissue
COSM1659171c.6547A>Tp.M2183LSubstitution - MissenseKidney
COSM5662599c.3787G>Tp.D1263YSubstitution - MissenseSoft_tissue
COSM5986989c.4902_4903delTTp.S1635fs*18Deletion - FrameshiftSalivary_gland
COSM1245560c.5948G>Ap.R1983HSubstitution - MissenseStomach
COSM206759c.2329C>Tp.R777CSubstitution - MissenseStomach
COSM5368987c.7056-1G>Ap.?UnknownHaematopoietic_and_lymphoid_tissue
COSM3667364c.4053G>Ap.G1351GSubstitution - coding silentLiver
COSM4622146c.4647A>Gp.L1549LSubstitution - coding silentLarge_intestine
COSM3474984c.296C>Tp.P99LSubstitution - MissenseSkin
COSM896951c.229G>Tp.E77*Substitution - NonsenseEndometrium
COSM5606329c.155G>Ap.R52QSubstitution - MissenseSkin
COSM206736c.8683delAp.T2895fs*44Deletion - FrameshiftOesophagus
COSM3996966c.829A>Gp.S277GSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM4605720c.6420A>Tp.Q2140HSubstitution - MissenseUpper_aerodigestive_tract
COSM5941457c.974C>Tp.P325LSubstitution - MissenseSkin
COSM1334660c.3665delAp.K1222fs*11Deletion - FrameshiftBiliary_tract
COSM1245558c.6387T>Cp.C2129CSubstitution - coding silentOesophagus
COSM3976199c.1789G>Cp.E597QSubstitution - MissenseLung
COSM2210758c.576G>Ap.T192TSubstitution - coding silentLarge_intestine
COSM896944c.1125A>Tp.K375NSubstitution - MissenseEndometrium
COSM3788784c.7870G>Cp.D2624HSubstitution - MissenseUrinary_tract
COSM896950c.349A>Gp.K117ESubstitution - MissenseEndometrium
COSM1747800c.6253G>Tp.G2085CSubstitution - MissenseUrinary_tract
COSM4767621c.3516G>Ap.S1172SSubstitution - coding silentBiliary_tract
COSM3705052c.4380C>Gp.L1460LSubstitution - coding silentLiver
COSM4425808c.24G>Cp.M8ISubstitution - MissenseOesophagus
COSM2210703c.4055G>Cp.R1352TSubstitution - MissenseOesophagus
COSM414449c.190G>Ap.D64NSubstitution - MissenseUrinary_tract
COSM4023054c.3916C>Tp.R1306*Substitution - NonsenseStomach
COSM352055c.4059C>Tp.P1353PSubstitution - coding silentLung
COSM206758c.3904C>Tp.R1302WSubstitution - MissenseStomach
COSM896935c.2615T>Gp.I872SSubstitution - MissenseEndometrium
COSM3862921c.1277C>Tp.A426VSubstitution - MissenseSkin
COSM5606329c.155G>Ap.R52QSubstitution - MissenseSkin
COSM238858c.3157C>Tp.R1053CSubstitution - MissenseLung
COSM3474965c.4494C>Tp.P1498PSubstitution - coding silentSkin
COSM4663704c.2300delCp.P767fs*4Deletion - FrameshiftLarge_intestine
COSM896905c.8145C>Tp.H2715HSubstitution - coding silentEndometrium
COSM5632139c.327A>Cp.R109RSubstitution - coding silentOesophagus
COSM5042739c.7190G>Ap.R2397QSubstitution - MissenseLiver
COSM243076c.3085T>Gp.F1029VSubstitution - MissenseProstate
COSM1725549c.5285C>Tp.P1762LSubstitution - MissenseLiver
COSM2210652c.6915A>Gp.G2305GSubstitution - coding silentLarge_intestine
COSM1736827c.8605G>Ap.A2869TSubstitution - MissenseCentral_nervous_system
COSM1334659c.3760C>Tp.R1254CSubstitution - MissenseLarge_intestine
COSM1334648c.7116delAp.K2372fs*5Deletion - FrameshiftLarge_intestine
COSM349792c.695C>Tp.S232FSubstitution - MissenseLung
COSM3705052c.4380C>Gp.L1460LSubstitution - coding silentLiver
COSM4970269c.5252G>Ap.R1751HSubstitution - MissenseCentral_nervous_system
COSM4605283c.3946C>Gp.L1316VSubstitution - MissenseUpper_aerodigestive_tract
COSM3740695c.3551C>Gp.T1184SSubstitution - MissenseLiver
COSM5795750c.4375C>Gp.P1459ASubstitution - MissenseBreast
COSM5754220c.1952G>Ap.G651ESubstitution - MissenseLarge_intestine
COSM1639526c.5843C>Ap.P1948QSubstitution - MissenseStomach
COSM3689037c.7976G>Ap.R2659HSubstitution - MissenseLarge_intestine
COSM5426506c.6882C>Gp.N2294KSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM5599096c.8072G>Ap.R2691QSubstitution - MissenseSkin
COSM69732c.3680T>Cp.F1227SSubstitution - MissenseOvary
COSM4023073c.154C>Tp.R52WSubstitution - MissenseStomach
COSM4605439c.4675C>Ap.R1559RSubstitution - coding silentUpper_aerodigestive_tract
COSM295972c.2119A>Gp.K707ESubstitution - MissenseLarge_intestine
COSM2210741c.1554G>Ap.K518KSubstitution - coding silentLarge_intestine
COSM3862915c.6353C>Tp.S2118FSubstitution - MissenseSkin
COSM206743c.7567C>Tp.R2523CSubstitution - MissenseSkin
COSM4474832c.1946C>Tp.S649FSubstitution - MissenseSkin
COSM1319913c.7113A>Gp.Q2371QSubstitution - coding silentOvary
COSM4999549c.2574G>Tp.Q858HSubstitution - MissensePancreas
COSM1688722c.5951C>Tp.P1984LSubstitution - MissenseSkin
COSM1660642c.1297C>Tp.Q433*Substitution - NonsenseKidney
COSM69733c.584C>Tp.T195ISubstitution - MissenseOvary
COSM238858c.3157C>Tp.R1053CSubstitution - MissenseProstate
COSM896925c.4477C>Tp.R1493CSubstitution - MissenseEndometrium
COSM3474961c.5855C>Tp.P1952LSubstitution - MissenseSkin
COSM98266c.2771C>Gp.S924CSubstitution - MissenseUpper_aerodigestive_tract
COSM4023035c.8844G>Ap.R2948RSubstitution - coding silentStomach
COSM5606329c.155G>Ap.R52QSubstitution - MissenseSkin
COSM3979875c.2092G>Ap.E698KSubstitution - MissenseOvary
COSM317025c.7699G>Ap.V2567ISubstitution - MissenseSoft_tissue
COSM896952c.216G>Ap.Q72QSubstitution - coding silentEndometrium
COSM1668036c.2503G>Tp.E835*Substitution - NonsenseLung
COSM4500047c.5569C>Tp.P1857SSubstitution - MissenseSkin
COSM4798149c.4969G>Ap.V1657ISubstitution - MissenseLiver
COSM4620298c.2963A>Gp.K988RSubstitution - MissenseLarge_intestine
COSM172621c.6436C>Tp.R2146*Substitution - NonsenseSkin
COSM341815c.1864A>Gp.I622VSubstitution - MissenseLung
COSM5745722c.3776A>Gp.Y1259CSubstitution - MissensePancreas
COSM5685831c.3295A>Tp.S1099CSubstitution - MissenseSoft_tissue
COSM414452c.7509G>Ap.V2503VSubstitution - coding silentUrinary_tract
COSM1472718c.3673C>Tp.H1225YSubstitution - MissenseBreast
COSM1295175c.6020G>Ap.R2007QSubstitution - MissenseUrinary_tract
COSM4822108c.6539G>Ap.R2180KSubstitution - MissenseCervix
COSM1334666c.2134delAp.R712fs*23Deletion - FrameshiftLarge_intestine
COSM3474970c.3131C>Gp.T1044SSubstitution - MissenseSkin
COSM4763009c.1211T>Cp.I404TSubstitution - MissenseStomach
COSM5719369c.2433C>Tp.S811SSubstitution - coding silentSkin
COSM4023058c.3310C>Gp.P1104ASubstitution - MissenseStomach
COSM4412149c.3092C>Gp.S1031CSubstitution - MissenseOesophagus
COSM5900654c.907G>Ap.D303NSubstitution - MissenseSkin
COSM896938c.2393A>Cp.K798TSubstitution - MissenseEndometrium
COSM309309c.832A>Tp.T278SSubstitution - MissenseLung
COSM172621c.6436C>Tp.R2146*Substitution - NonsenseSkin
COSM675755c.5203G>Cp.D1735HSubstitution - MissenseLung
COSM896931c.3456G>Tp.K1152NSubstitution - MissenseEndometrium
COSM3788788c.2659C>Gp.P887ASubstitution - MissenseUrinary_tract
COSM3862918c.4377C>Tp.P1459PSubstitution - coding silentSkin
COSM2210712c.3935C>Tp.P1312LSubstitution - MissenseLarge_intestine
COSM5813519c.3249A>Tp.S1083SSubstitution - coding silentLiver
COSM896926c.4457G>Ap.R1486HSubstitution - MissenseEndometrium
COSM1688723c.2314C>Tp.H772YSubstitution - MissenseSkin
COSM4954934c.4080G>Tp.M1360ISubstitution - MissenseLiver
COSM206736c.8683delAp.T2895fs*44Deletion - FrameshiftLarge_intestine
COSM1168642c.1884G>Tp.G628GSubstitution - coding silentPancreas
COSM110349c.4114C>Tp.P1372SSubstitution - MissenseSkin
COSM279000c.1777G>Ap.E593KSubstitution - MissenseBreast
COSM2210733c.2602T>Cp.L868LSubstitution - coding silentLarge_intestine
COSM392336c.8683_8684insAp.T2895fs*5Insertion - FrameshiftOesophagus
COSM4504361c.6638C>Tp.A2213VSubstitution - MissenseSkin
COSM4663699c.6375C>Tp.G2125GSubstitution - coding silentLarge_intestine
COSM1626485c.4624C>Tp.H1542YSubstitution - MissenseLiver
COSM5017388c.8684_8685insAp.E2896fs*4Insertion - FrameshiftSoft_tissue
COSM2210696c.4448A>Gp.H1483RSubstitution - MissenseOesophagus
COSM3769697c.7482G>Tp.Q2494HSubstitution - MissenseSoft_tissue
COSM3700496c.6550A>Gp.I2184VSubstitution - MissenseLiver
COSM5352966c.7745G>Ap.R2582HSubstitution - MissenseLarge_intestine
COSM4633340c.4275C>Ap.S1425SSubstitution - coding silentLarge_intestine
COSM3414568c.6104-8_6104-7insTp.?UnknownLarge_intestine
COSM2210628c.8282C>Tp.T2761MSubstitution - MissenseLarge_intestine
COSM3399799c.3420C>Gp.S1140SSubstitution - coding silentCentral_nervous_system
COSM4023037c.7687A>Gp.S2563GSubstitution - MissenseStomach
COSM3474954c.7411C>Tp.P2471SSubstitution - MissenseSkin
COSM896928c.3962G>Ap.R1321QSubstitution - MissenseBiliary_tract
COSM3360374c.3511C>Tp.P1171SSubstitution - MissenseKidney
COSM896924c.4483T>Cp.S1495PSubstitution - MissenseEndometrium
COSM373926c.4587G>Ap.K1529KSubstitution - coding silentLung
COSM3474967c.4232C>Tp.P1411LSubstitution - MissenseSkin
COSM3934122c.6722C>Tp.A2241VSubstitution - MissenseOesophagus
COSM4842721c.1009G>Cp.D337HSubstitution - MissenseCervix
COSM5781579c.1332C>Tp.I444ISubstitution - coding silentBreast
COSM1334660c.3665delAp.K1222fs*11Deletion - FrameshiftLarge_intestine
COSM366974c.5709T>Gp.S1903RSubstitution - MissenseLung
COSM3802115c.3580G>Ap.D1194NSubstitution - MissenseBreast
COSM1334647c.7602A>Cp.L2534LSubstitution - coding silentLarge_intestine
COSM896910c.6827G>Ap.R2276QSubstitution - MissenseEndometrium
COSM3355896c.4999T>Cp.S1667PSubstitution - MissenseBreast
COSM1737509c.1681A>Gp.T561ASubstitution - MissenseCentral_nervous_system
COSM206760c.2056G>Tp.A686SSubstitution - MissensePancreas
COSM463111c.505G>Tp.G169*Substitution - NonsenseKidney
COSM2210741c.1554G>Ap.K518KSubstitution - coding silentSkin
COSM4763007c.3502C>Tp.P1168SSubstitution - MissenseStomach
COSM463109c.2461T>Cp.S821PSubstitution - MissenseKidney
COSM3385238c.8857C>Tp.R2953CSubstitution - MissensePancreas
COSM3418119c.3938G>Ap.R1313QSubstitution - MissenseLarge_intestine
COSM1334650c.6794A>Gp.Q2265RSubstitution - MissenseLarge_intestine
COSM309309c.832A>Tp.T278SSubstitution - MissenseSoft_tissue
COSM4576346c.1107T>Cp.N369NSubstitution - coding silentBone
COSM3705048c.7142A>Gp.D2381GSubstitution - MissenseLiver
COSM424059c.6224-2_6224delAGAp.?UnknownBreast
COSM424065c.1366C>Gp.L456VSubstitution - MissenseBreast
COSM3474956c.6988G>Ap.E2330KSubstitution - MissenseSkin
COSM3788786c.6574G>Ap.D2192NSubstitution - MissenseUrinary_tract
COSM5894195c.3197G>Tp.S1066ISubstitution - MissenseSkin
COSM5985140c.5843C>Gp.P1948RSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3705049c.5992G>Ap.V1998ISubstitution - MissenseLiver
COSM4023041c.6877A>Gp.K2293ESubstitution - MissenseStomach
COSM2210718c.3595A>Gp.S1199GSubstitution - MissenseLarge_intestine
COSM1295176c.3574C>Tp.H1192YSubstitution - MissenseUrinary_tract
COSM4576347c.891A>Gp.V297VSubstitution - coding silentBone
COSM206736c.8683delAp.T2895fs*44Deletion - FrameshiftBiliary_tract
COSM206736c.8683delAp.T2895fs*44Deletion - FrameshiftStomach
COSM896932c.3449C>Tp.A1150VSubstitution - MissenseEndometrium
COSM5634243c.2706G>Tp.K902NSubstitution - MissenseOesophagus
COSM1334660c.3665delAp.K1222fs*11Deletion - FrameshiftBreast
COSM1334651c.5465delAp.N1822fs*2Deletion - FrameshiftLarge_intestine
COSM5788443c.2374C>Gp.L792VSubstitution - MissenseBreast
COSM278999c.3917G>Ap.R1306QSubstitution - MissenseLarge_intestine
COSM4954934c.4080G>Tp.M1360ISubstitution - MissenseLiver
COSM4663706c.830G>Ap.S277NSubstitution - MissenseLarge_intestine
COSM5881528c.3997T>Gp.F1333VSubstitution - MissenseSkin
COSM5905358c.7909C>Tp.R2637WSubstitution - MissenseSkin
COSM126560c.4660G>Tp.E1554*Substitution - NonsenseUpper_aerodigestive_tract
COSM4023042c.6553G>Cp.E2185QSubstitution - MissenseStomach
COSM5606329c.155G>Ap.R52QSubstitution - MissenseSkin
COSM5941458c.973C>Tp.P325SSubstitution - MissenseSkin
COSM5341585c.6543C>Gp.N2181KSubstitution - MissenseLarge_intestine
COSM6006618c.6406C>Tp.H2136YSubstitution - MissenseProstate
COSM675757c.5893G>Cp.E1965QSubstitution - MissenseLung
COSM2210638c.7597C>Tp.R2533CSubstitution - MissenseLarge_intestine
COSM4396299c.6800T>Gp.L2267RSubstitution - MissenseSkin
COSM206736c.8683delAp.T2895fs*44Deletion - FrameshiftStomach
COSM1668035c.5465A>Cp.N1822TSubstitution - MissenseLarge_intestine
COSM278999c.3917G>Ap.R1306QSubstitution - MissenseLarge_intestine
COSM1245561c.5410C>Tp.Q1804*Substitution - NonsenseOesophagus
COSM896933c.3191C>Ap.S1064YSubstitution - MissenseEndometrium
COSM2210741c.1554G>Ap.K518KSubstitution - coding silentLarge_intestine
COSM405019c.7804-1_7814delGGTATGGCAGCAp.?UnknownLung
COSM3474971c.3054C>Tp.L1018LSubstitution - coding silentSkin
COSM5052622c.6241A>Gp.K2081ESubstitution - MissenseStomach
COSM896915c.6479T>Gp.L2160RSubstitution - MissenseEndometrium
COSM463106c.7681G>Tp.D2561YSubstitution - MissenseKidney
COSM3705046c.8120+8C>Tp.?UnknownLiver
COSM3802114c.3677C>Ap.S1226YSubstitution - MissenseBreast
COSM4023064c.2148A>Cp.K716NSubstitution - MissenseStomach
COSM4891320c.5975C>Ap.A1992ESubstitution - MissenseUpper_aerodigestive_tract
COSM3474953c.7872C>Tp.D2624DSubstitution - coding silentSkin
COSM3474958c.6586C>Tp.L2196LSubstitution - coding silentSkin
COSM896919c.5561G>Ap.R1854QSubstitution - MissenseEndometrium
COSM354056c.592G>Tp.G198CSubstitution - MissenseLung
COSM414450c.2311G>Cp.D771HSubstitution - MissenseUrinary_tract
COSM1600921c.8660A>Cp.N2887TSubstitution - MissenseLiver
COSM1472719c.3490_3492delCCTp.P1164delPDeletion - In frameBreast
COSM896927c.4334A>Cp.K1445TSubstitution - MissenseEndometrium
COSM3396125c.8147A>Tp.H2716LSubstitution - MissenseProstate
COSM1127359c.2916G>Tp.K972NSubstitution - MissenseProstate
COSM4023051c.4546C>Tp.R1516CSubstitution - MissenseStomach
COSM4140864c.981T>Cp.T327TSubstitution - coding silentKidney
COSM4023059c.3149G>Ap.R1050KSubstitution - MissenseStomach
COSM3976198c.1790A>Tp.E597VSubstitution - MissenseLung
COSM1183763c.4547G>Ap.R1516HSubstitution - MissenseLarge_intestine
COSM1660643c.760A>Gp.I254VSubstitution - MissenseKidney
COSM1295178c.396G>Ap.K132KSubstitution - coding silentUrinary_tract
COSM1737509c.1681A>Gp.T561ASubstitution - MissenseStomach
COSM5962438c.2950C>Tp.R984CSubstitution - MissenseBreast
COSM212134c.1968G>Cp.L656FSubstitution - MissenseBreast
COSM1668035c.5465A>Cp.N1822TSubstitution - MissenseLarge_intestine
COSM896928c.3962G>Ap.R1321QSubstitution - MissenseEndometrium
COSM896928c.3962G>Ap.R1321QSubstitution - MissenseEndometrium
COSM675751c.3414A>Gp.L1138LSubstitution - coding silentLung
COSM3984293c.8094C>Tp.R2698RSubstitution - coding silentKidney
COSM5916984c.5240C>Tp.S1747FSubstitution - MissenseSkin
COSM170344c.6217C>Tp.R2073CSubstitution - MissenseSkin
COSM3385239c.5050C>Tp.R1684WSubstitution - MissensePancreas
COSM896913c.6706C>Tp.R2236WSubstitution - MissenseEndometrium
COSM3474972c.2767G>Ap.E923KSubstitution - MissenseSkin
COSM5599096c.8072G>Ap.R2691QSubstitution - MissenseSkin
COSM675747c.2299C>Tp.P767SSubstitution - MissenseLung
COSM392336c.8683_8684insAp.T2895fs*5Insertion - FrameshiftLarge_intestine
COSM279000c.1777G>Ap.E593KSubstitution - MissenseEndometrium
COSM4142794c.2592A>Gp.E864ESubstitution - coding silentThyroid
COSM4626835c.7914C>Tp.P2638PSubstitution - coding silentLarge_intestine
COSM4391532c.8370C>Gp.Y2790*Substitution - NonsenseBreast
COSM4605488c.4942G>Ap.E1648KSubstitution - MissenseUpper_aerodigestive_tract
COSM1747801c.3809G>Ap.R1270QSubstitution - MissenseUrinary_tract
COSM365973c.7982-2A>Tp.?UnknownLung
COSM4605050c.3023C>Gp.S1008*Substitution - NonsenseUpper_aerodigestive_tract
COSM896943c.1477G>Tp.E493*Substitution - NonsenseEndometrium
COSM1245557c.969A>Tp.K323NSubstitution - MissenseOesophagus
COSM4888672c.5961G>Ap.K1987KSubstitution - coding silentUpper_aerodigestive_tract
COSM3984295c.7178A>Gp.N2393SSubstitution - MissenseStomach
COSM3862916c.5098C>Tp.P1700SSubstitution - MissenseSkin
COSM5052624c.4257G>Ap.T1419TSubstitution - coding silentStomach
COSM424057c.8331C>Tp.I2777ISubstitution - coding silentBreast
COSM4617143c.4810A>Gp.T1604ASubstitution - MissenseLarge_intestine
COSM4663693c.8801_8802insAp.N2934fs*4Insertion - FrameshiftLarge_intestine
COSM5505105c.355C>Ap.P119TSubstitution - MissenseBiliary_tract
COSM5377845c.7366+1G>Ap.?UnknownSkin
COSM206736c.8683delAp.T2895fs*44Deletion - FrameshiftLarge_intestine
COSM4816530c.6891C>Tp.P2297PSubstitution - coding silentCervix
COSM3976196c.8401A>Tp.T2801SSubstitution - MissenseLung
COSM5377844c.7905C>Tp.I2635ISubstitution - coding silentSkin
COSM5781158c.1114T>Cp.L372LSubstitution - coding silentBreast
COSM3396125c.8147A>Tp.H2716LSubstitution - MissenseProstate
COSM206744c.7108C>Tp.R2370CSubstitution - MissenseSkin
COSM675752c.3800G>Tp.R1267MSubstitution - MissenseLung
COSM1334665c.2908delAp.I970fs*9Deletion - FrameshiftLarge_intestine
COSM206736c.8683delAp.T2895fs*44Deletion - FrameshiftLarge_intestine
COSM896904c.8163C>Tp.H2721HSubstitution - coding silentLarge_intestine
COSM896934c.2985G>Tp.K995NSubstitution - MissenseEndometrium
COSM896906c.7744C>Tp.R2582CSubstitution - MissenseEndometrium
COSM2210717c.3616G>Tp.D1206YSubstitution - MissenseLarge_intestine
COSM4766645c.7032G>Ap.M2344ISubstitution - MissenseStomach
COSM1197419c.7750A>Gp.I2584VSubstitution - MissenseLung
COSM2210731c.2752A>Cp.S918RSubstitution - MissenseLarge_intestine
COSM1334660c.3665delAp.K1222fs*11Deletion - FrameshiftStomach
COSM4023044c.6154C>Ap.L2052ISubstitution - MissenseStomach
COSM1334670c.123A>Cp.K41NSubstitution - MissenseLarge_intestine
COSM5759009c.3407T>Cp.L1136SSubstitution - MissenseBone
COSM3788789c.2512C>Gp.Q838ESubstitution - MissenseUrinary_tract
COSM4519779c.1028G>Ap.G343ESubstitution - MissenseSkin
COSM39706c.3127G>Cp.G1043RSubstitution - MissenseCentral_nervous_system
COSM896929c.3744_3745delTAp.H1248fs*5Deletion - FrameshiftEndometrium
COSM1747801c.3809G>Ap.R1270QSubstitution - MissenseUrinary_tract
COSM4663703c.3844A>Gp.R1282GSubstitution - MissenseLarge_intestine
COSM4904934c.1947C>Tp.S649SSubstitution - coding silentSkin
COSM4796206c.5042G>Ap.S1681NSubstitution - MissenseLiver
COSM4023072c.224T>Cp.V75ASubstitution - MissenseStomach
COSM4023053c.4129G>Ap.G1377RSubstitution - MissenseStomach
COSM3369321c.278C>Gp.A93GSubstitution - MissenseThyroid
COSM5892521c.1077A>Tp.L359FSubstitution - MissenseSkin
COSM1747800c.6253G>Tp.G2085CSubstitution - MissenseUrinary_tract
COSM2210770c.189T>Cp.D63DSubstitution - coding silentLarge_intestine
COSM3689038c.3890G>Ap.R1297HSubstitution - MissenseLarge_intestine
COSM4763000c.6306G>Tp.K2102NSubstitution - MissenseStomach
COSM1472720c.1833G>Cp.L611FSubstitution - MissenseBreast
COSM349791c.1240G>Ap.A414TSubstitution - MissenseLung
COSM4023074c.2T>Cp.M1TSubstitution - MissenseStomach
COSM463107c.5991C>Tp.D1997DSubstitution - coding silentKidney
COSM3934123c.3761G>Ap.R1254HSubstitution - MissenseOesophagus
COSM1334646c.7604G>Ap.R2535QSubstitution - MissenseLarge_intestine
COSM3474971c.3054C>Tp.L1018LSubstitution - coding silentSkin
COSM3802112c.7690G>Cp.E2564QSubstitution - MissenseBreast
COSM392336c.8683_8684insAp.T2895fs*5Insertion - FrameshiftLung
COSM238859c.754_755insATTTp.I254fs*16Insertion - FrameshiftProstate
COSM4880987c.1943C>Tp.S648FSubstitution - MissenseProstate
COSM5692317c.4439A>Tp.E1480VSubstitution - MissenseSoft_tissue
COSM333340c.3911C>Tp.T1304ISubstitution - MissenseLung
COSM4023061c.2508G>Ap.M836ISubstitution - MissenseStomach
COSM4023069c.711G>Ap.P237PSubstitution - coding silentUpper_aerodigestive_tract
COSM268716c.5943C>Ap.P1981PSubstitution - coding silentLarge_intestine
COSM896907c.7731C>Tp.D2577DSubstitution - coding silentEndometrium
COSM896922c.4568C>Tp.A1523VSubstitution - MissenseEndometrium
COSM5952682c.2120A>Gp.K707RSubstitution - MissenseOesophagus
COSM5599096c.8072G>Ap.R2691QSubstitution - MissenseSkin
COSM1197404c.8134G>Tp.A2712SSubstitution - MissenseLung
COSM4606780c.6136C>Tp.Q2046*Substitution - NonsenseAdrenal_gland
COSM2210751c.1097G>Ap.G366ESubstitution - MissenseUpper_aerodigestive_tract
COSM3474979c.1713C>Tp.P571PSubstitution - coding silentSkin
COSM4663695c.8450A>Gp.K2817RSubstitution - MissenseLarge_intestine
COSM3474950c.8269T>Cp.L2757LSubstitution - coding silentSkin
COSM1600922c.5945delCp.P1982fs*27Deletion - FrameshiftLiver
COSM5429141c.7677G>Ap.E2559ESubstitution - coding silentOesophagus
COSM5625721c.7307G>Cp.R2436PSubstitution - MissenseOesophagus
COSM896928c.3962G>Ap.R1321QSubstitution - MissenseStomach
COSM896951c.229G>Tp.E77*Substitution - NonsenseEndometrium
COSM4023060c.3022T>Cp.S1008PSubstitution - MissenseStomach
COSM1283531c.971A>Gp.K324RSubstitution - MissenseAutonomic_ganglia
COSM3934122c.6722C>Tp.A2241VSubstitution - MissenseBiliary_tract
COSM3705047c.8120+5G>Tp.?UnknownLiver
COSM2210735c.2494A>Gp.K832ESubstitution - MissenseLung
COSM170344c.6217C>Tp.R2073CSubstitution - MissenseSkin
COSM5451149c.773G>Ap.G258DSubstitution - MissenseLarge_intestine
COSM529268c.2902A>Tp.K968*Substitution - NonsenseAdrenal_gland
COSM5645099c.4333A>Tp.K1445*Substitution - NonsenseOesophagus
COSM896936c.2538T>Ap.T846TSubstitution - coding silentEndometrium
COSM5619284c.4629C>Gp.L1543LSubstitution - coding silentBreast
COSM3474951c.8232C>Tp.I2744ISubstitution - coding silentSkin
COSM4940528c.8612A>Cp.N2871TSubstitution - MissenseLiver
COSM3376006c.4792G>Cp.A1598PSubstitution - MissensePancreas
COSM4663694c.8460G>Ap.S2820SSubstitution - coding silentLarge_intestine
COSM5719369c.2433C>Tp.S811SSubstitution - coding silentSkin
COSM3802113c.4970T>Cp.V1657ASubstitution - MissenseBreast
COSM3689039c.1046G>Tp.G349VSubstitution - MissenseLarge_intestine
COSM3705051c.4550A>Gp.Y1517CSubstitution - MissenseLiver
COSM1197284c.4171C>Tp.L1391FSubstitution - MissenseLung
COSM3474968c.4183C>Tp.P1395SSubstitution - MissenseSkin
COSM896930c.3645G>Tp.E1215DSubstitution - MissenseEndometrium
COSM2210638c.7597C>Tp.R2533CSubstitution - MissenseStomach
COSM5905359c.7370C>Tp.S2457FSubstitution - MissenseSkin
COSM5911208c.7075C>Tp.H2359YSubstitution - MissenseSkin
COSM424062c.4486G>Cp.E1496QSubstitution - MissenseBreast
COSM896945c.575C>Tp.T192MSubstitution - MissenseEndometrium
COSM4839330c.184A>Gp.K62ESubstitution - MissenseCervix
COSM896913c.6706C>Tp.R2236WSubstitution - MissenseAdrenal_gland
COSM170344c.6217C>Tp.R2073CSubstitution - MissenseLarge_intestine
COSM414451c.2994G>Cp.L998FSubstitution - MissenseUrinary_tract
COSM3862919c.4139C>Tp.P1380LSubstitution - MissenseSkin
COSM896906c.7744C>Tp.R2582CSubstitution - MissenseSkin
COSM5095169c.4280T>Cp.M1427TSubstitution - MissenseThymus
COSM3705047c.8120+5G>Tp.?UnknownLiver
COSM5453929c.7820A>Gp.D2607GSubstitution - MissenseLarge_intestine
COSM295638c.7833G>Tp.V2611VSubstitution - coding silentLarge_intestine
COSM5991666c.869delAp.K290fs*8Deletion - FrameshiftProstate
COSM463110c.578C>Ap.P193QSubstitution - MissenseKidney
COSM4023045c.5472C>Tp.D1824DSubstitution - coding silentStomach
COSM675748c.3123G>Ap.K1041KSubstitution - coding silentLung
COSM2210714c.3838C>Tp.R1280*Substitution - NonsenseSkin
COSM896949c.417A>Gp.K139KSubstitution - coding silentEndometrium
COSM400848c.2899G>Tp.D967YSubstitution - MissenseLung
COSM236057c.4769G>Tp.G1590VSubstitution - MissenseAutonomic_ganglia
COSM1319912c.6236_6238delATGp.D2079delDDeletion - In frameOvary
COSM1193141c.3814C>Tp.R1272WSubstitution - MissenseCervix
COSM3360373c.7428T>Ap.A2476ASubstitution - coding silentKidney
COSM5934222c.3271C>Tp.P1091SSubstitution - MissenseSkin
COSM177558c.161G>Ap.R54QSubstitution - MissenseLarge_intestine
COSM1134719c.7733A>Gp.D2578GSubstitution - MissenseKidney
COSM3667019c.6346G>Tp.E2116*Substitution - NonsenseLiver
COSM4663705c.1823G>Ap.S608NSubstitution - MissenseLarge_intestine
COSM5224054c.6427delGp.E2143fs*18Deletion - FrameshiftBreast
COSM5719369c.2433C>Tp.S811SSubstitution - coding silentSkin
COSM896941c.2193A>Gp.P731PSubstitution - coding silentEndometrium
COSM3474976c.2123C>Tp.P708LSubstitution - MissenseSkin
COSM4023055c.3889C>Tp.R1297CSubstitution - MissenseStomach
COSM3984294c.7636T>Cp.S2546PSubstitution - MissenseKidney
COSM5719369c.2433C>Tp.S811SSubstitution - coding silentSkin
COSM206745c.6826C>Tp.R2276*Substitution - NonsenseLiver
COSM3355896c.4999T>Cp.S1667PSubstitution - MissenseBreast
COSM4023038c.7568G>Ap.R2523HSubstitution - MissenseStomach
COSM5898080c.5299G>Ap.V1767MSubstitution - MissenseSkin
COSM4663702c.4024C>Tp.R1342*Substitution - NonsenseLarge_intestine
COSM1688721c.7855C>Tp.L2619FSubstitution - MissenseSkin
COSM5631653c.1641C>Tp.F547FSubstitution - coding silentOesophagus
COSM288587c.6945C>Ap.H2315QSubstitution - MissenseLarge_intestine
COSM5963350c.5270G>Ap.R1757QSubstitution - MissenseBreast
COSM1334645c.8014C>Tp.R2672CSubstitution - MissenseLarge_intestine
COSM1295177c.3439C>Tp.Q1147*Substitution - NonsenseUrinary_tract
COSM4023071c.312G>Ap.E104ESubstitution - coding silentStomach
COSM896908c.7638A>Gp.S2546SSubstitution - coding silentEndometrium
COSM4533947c.2030G>Ap.S677NSubstitution - MissenseSkin
COSM206739c.8212C>Tp.R2738WSubstitution - MissenseEndometrium
COSM4904658c.6251C>Tp.S2084FSubstitution - MissenseSkin
COSM4023069c.711G>Ap.P237PSubstitution - coding silentStomach
COSM4885423c.2912C>Tp.T971ISubstitution - MissenseUpper_aerodigestive_tract
COSM4637268c.8288G>Ap.C2763YSubstitution - MissenseLarge_intestine
COSM3984298c.136G>Ap.E46KSubstitution - MissenseKidney
COSM424058c.8223C>Tp.L2741LSubstitution - coding silentBreast
COSM3667364c.4053G>Ap.G1351GSubstitution - coding silentLiver
COSM3474966c.4412C>Tp.P1471LSubstitution - MissenseSkin
COSM675759c.7499A>Gp.Y2500CSubstitution - MissenseLung
COSM1334658c.4086A>Gp.E1362ESubstitution - coding silentLarge_intestine
COSM896918c.6045G>Ap.K2015KSubstitution - coding silentEndometrium
COSM4023056c.3617A>Tp.D1206VSubstitution - MissenseStomach
COSM5632139c.327A>Cp.R109RSubstitution - coding silentOesophagus
COSM2210668c.6091C>Tp.P2031SSubstitution - MissenseLarge_intestine
COSM106683c.4862C>Tp.S1621FSubstitution - MissenseSkin
COSM1245559c.273C>Ap.L91LSubstitution - coding silentOesophagus
COSM3474964c.4629C>Tp.L1543LSubstitution - coding silentSkin
COSM3705051c.4550A>Gp.Y1517CSubstitution - MissenseLiver
COSM30721c.5130G>Ap.G1710GSubstitution - coding silentKidney
COSM3474974c.2225T>Ap.F742YSubstitution - MissenseSkin
COSM4855835c.6930G>Ap.K2310KSubstitution - coding silentCervix
COSM4023062c.2498C>Gp.S833CSubstitution - MissenseStomach
COSM5038070c.6520G>Ap.V2174ISubstitution - MissenseSkin
COSM5613770c.3127G>Ap.G1043RSubstitution - MissenseLung
COSM4780617c.5414G>Cp.R1805PSubstitution - MissenseLiver
COSM1293218c.1390A>Gp.T464ASubstitution - MissenseCervix
COSM279000c.1777G>Ap.E593KSubstitution - MissenseLarge_intestine
COSM3934125c.2383G>Ap.D795NSubstitution - MissenseOesophagus
COSM2210718c.3595A>Gp.S1199GSubstitution - MissenseLarge_intestine
COSM3474975c.2203G>Cp.E735QSubstitution - MissenseSkin
COSM5806815c.3448G>Tp.A1150SSubstitution - MissenseLiver
COSM331892c.3276A>Gp.L1092LSubstitution - coding silentLung
COSM3689037c.7976G>Ap.R2659HSubstitution - MissenseStomach
COSM5599096c.8072G>Ap.R2691QSubstitution - MissenseSkin
COSM3705048c.7142A>Gp.D2381GSubstitution - MissenseLiver
COSM3788787c.4357C>Gp.L1453VSubstitution - MissenseUrinary_tract
COSM4663697c.7804-1G>Tp.?UnknownLarge_intestine
COSM896911c.6792A>Gp.K2264KSubstitution - coding silentEndometrium
COSM3667019c.6346G>Tp.E2116*Substitution - NonsenseLiver
COSM5599096c.8072G>Ap.R2691QSubstitution - MissenseSkin
COSM3667363c.4091C>Tp.P1364LSubstitution - MissenseLiver
COSM4663698c.6721G>Ap.A2241TSubstitution - MissenseLarge_intestine
COSM5025373c.5325C>Tp.C1775CSubstitution - coding silentProstate
> Text Mining based Variations
 
PMID Variation Cancer Evidence
25450519MutationGastric CarcinomaUsing SSCP in conjunction with DNA sequencing we detected frameshift mutations in AGXT (17 cases), ALDH2 (3 cases), APIP (4 cases), MTR (5 cases), DNMT1 (1 case), ASH1L (1 case), ASPA (2 cases), CAD (2 cases), DDC (1 case), GCDH (3 cases), DLD (1 case), LAP3 (1 case), MCEE (5 cases) and MUT (1 case).
24755471MutationColorectal CarcinomaFurthermore, we documented mutations enriched in genes involved in chromatin remodeling (ARID1A, CHD6, and SRCAP) and histone methylation or acetylation (ASH1L, EP300, EP400, MLL2, MLL3, PRDM2, and TRRAP).
23033341MutationLung CarcinomaA number of epigenetic regulators, including KDM6A, ASH1L, SMARCA4, and ATAD2, are frequently altered by mutations or copy number changes. The ASH1L gene is mutated in nine cell lines.
26292256Overexpression; copy number gain; mutationBreast Carcinoma; Thyroid Gland Carcinoma; Lung Carcinoma; Cervical CarcinomaIn breast cancer, 27 percent of aggressive, basal-like breast cancers have high-level copy number amplifications of theASH1Lgene. Moreover, high levels of ASH1L mRNA are associated with shorter survival in breast cancer patients. In thyroid cancer, ASH1L is overexpressed in tumor-specific truncated forms and is downregulated by a tumor suppressor microRNA. Amplifications of ASH1L are found in a variety of other tumors, such as lung and uterine cancer, while mutations in ASH1L have been identified in gastric cancer, colorectal cancer, esophageal squamous cell cancer, and lung cancer.
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
Uniprot ID Position Amino Acid Description Upstream Enzyme Affected By Mutation Amino Acid Sequence Variant
Q9NR48375KN6-acetyllysine-Yesp.K375N (cancer: UCEC)
Q9NR481162SPhosphoserine-NoNone detected
Q9NR481170SPhosphoserine-NoNone detected
Q9NR482317KN6-acetyllysine-NoNone detected
Q9NR482319KN6-acetyllysine-NoNone detected
Q9NR482323KN6-acetyllysine-NoNone detected
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
BLCABladder urothelial carcinoma194086.3655.852-0.6710.000503Under
BRCABreast invasive carcinoma11211007.4237.135-0.2370.00317NS
CESCCervical and endocervical cancers33066.5846.073NANANA
COADColon adenocarcinoma414596.3265.76-0.5346.61e-07NS
ESCAEsophageal carcinoma111857.267.074-0.2740.175NS
GBMGlioblastoma multiforme51667.5746.136NANANA
HNSCHead and Neck squamous cell carcinoma445226.3645.977-0.3310.0108NS
KIRCKidney renal clear cell carcinoma725346.9376.398-0.6134.35e-14Under
KIRPKidney renal papillary cell carcinoma322916.7025.83-0.7942.55e-08Under
LAMLAcute Myeloid Leukemia0173NA8.339NANANA
LGGBrain Lower Grade Glioma0530NA7.139NANANA
LIHCLiver hepatocellular carcinoma503734.6514.9820.3940.00193NS
LUADLung adenocarcinoma595176.4156.4480.1570.102NS
LUSCLung squamous cell carcinoma515016.3196.291-0.0470.622NS
OVOvarian serous cystadenocarcinoma0307NA6.483NANANA
PAADPancreatic adenocarcinoma41796.1286.197NANANA
PCPGPheochromocytoma and Paraganglioma31846.0196.376NANANA
PRADProstate adenocarcinoma524986.9446.545-0.3710.000416NS
READRectum adenocarcinoma101676.3015.984-0.5460.0377NS
SARCSarcoma22635.9766.046NANANA
SKCMSkin Cutaneous Melanoma14725.9596.222NANANA
STADStomach adenocarcinoma354157.0076.95-0.0130.915NS
TGCTTesticular Germ Cell Tumors0156NA5.472NANANA
THCAThyroid carcinoma595097.0376.535-0.4629.81e-07NS
THYMThymoma21206.4075.903NANANA
UCECUterine Corpus Endometrial Carcinoma355466.5155.719-0.8665.9e-11Under
> Cancer Cell Line Encyclopedia (CCLE)
 



Tissue Cell Line Expression Level (Microarray)
Autonomic ganglia CHP126 10
Autonomic ganglia CHP212 10.1
Autonomic ganglia IMR32 10
Autonomic ganglia KELLY 10.1
Autonomic ganglia KPNRTBM1 9.8
Autonomic ganglia KPNSI9S 9.9
Autonomic ganglia KPNYN 10
Autonomic ganglia MHHNB11 9.4
Autonomic ganglia NB1 10.1
Autonomic ganglia NH6 9.9
Autonomic ganglia SHSY5Y 10.2
Autonomic ganglia SIMA 9.7
Autonomic ganglia SKNAS 9.7
Autonomic ganglia SKNBE2 10.4
Autonomic ganglia SKNDZ 9.6
Autonomic ganglia SKNFI 8.8
Autonomic ganglia SKNSH 8.9
Biliary tract HUCCT1 9
Biliary tract HUH28 9.1
Biliary tract SNU1079 9.3
Biliary tract SNU1196 9.6
Biliary tract SNU245 9.6
Biliary tract SNU308 9.2
Biliary tract SNU478 9.1
Bone 143B 7.9
Bone A673 9.4
Bone CADOES1 9.6
Bone CAL78 9
Bone G292CLONEA141B1 9.7
Bone HOS 8.5
Bone HS706T 9.2
Bone HS737T 9.2
Bone HS819T 9.2
Bone HS821T 8.8
Bone HS822T 9.2
Bone HS863T 8.7
Bone HS870T 8.8
Bone HS888T 9.1
Bone MG63 9.7
Bone MHHES1 9.8
Bone OUMS27 9.3
Bone RDES 9.8
Bone SJSA1 9.5
Bone SKES1 9.8
Bone SKNMC 9.5
Bone SW1353 9
Bone T173 9.1
Bone TC71 9.5
Bone U2OS 9.4
Breast AU565 9.8
Breast BT20 9.7
Breast BT474 9.3
Breast BT483 10.6
Breast BT549 8.8
Breast CAL120 8.5
Breast CAL148 9.9
Breast CAL51 9.4
Breast CAL851 8.8
Breast CAMA1 10.6
Breast DU4475 10.3
Breast EFM192A 9.8
Breast EFM19 10.3
Breast EVSAT 9.6
Breast HCC1143 9.4
Breast HCC1187 10
Breast HCC1395 9.3
Breast HCC1419 9.6
Breast HCC1428 9.8
Breast HCC1500 9.1
Breast HCC1569 10.1
Breast HCC1599 10.4
Breast HCC1806 9.2
Breast HCC1937 9.1
Breast HCC1954 9.8
Breast HCC202 10.1
Breast HCC2157 10.3
Breast HCC2218 10.2
Breast HCC38 9.6
Breast HCC70 10
Breast HDQP1 8.9
Breast HMC18 9.2
Breast HS274T 9
Breast HS281T 8.9
Breast HS343T 8.9
Breast HS578T 8.6
Breast HS606T 9.2
Breast HS739T 9.3
Breast HS742T 8.6
Breast JIMT1 8.3
Breast KPL1 9.9
Breast MCF7 9.4
Breast MDAMB134VI 9.1
Breast MDAMB157 9.6
Breast MDAMB175VII 10.4
Breast MDAMB231 9.2
Breast MDAMB361 9.1
Breast MDAMB415 9.5
Breast MDAMB436 9.1
Breast MDAMB453 10
Breast MDAMB468 9.5
Breast SKBR3 10
Breast T47D 10.2
Breast UACC812 11.1
Breast UACC893 9.5
Breast YMB1 10.8
Breast ZR751 10.5
Breast ZR7530 10.3
Central nervous system 1321N1 9.6
Central nervous system 42MGBA 9
Central nervous system 8MGBA 9
Central nervous system A172 9.5
Central nervous system AM38 8.7
Central nervous system BECKER 9.4
Central nervous system CAS1 9.1
Central nervous system CCFSTTG1 9.4
Central nervous system D283MED 10.1
Central nervous system D341MED 10.6
Central nervous system DAOY 9.2
Central nervous system DBTRG05MG 8.3
Central nervous system DKMG 9.3
Central nervous system GAMG 8.6
Central nervous system GB1 9.1
Central nervous system GI1 9.7
Central nervous system GMS10 9
Central nervous system GOS3 9.6
Central nervous system H4 9
Central nervous system HS683 9.4
Central nervous system KALS1 9.2
Central nervous system KG1C 8.8
Central nervous system KNS42 9.7
Central nervous system KNS60 8.9
Central nervous system KNS81 9.1
Central nervous system KS1 9.5
Central nervous system LN18 9
Central nervous system LN229 9.6
Central nervous system M059K 9.4
Central nervous system MOGGCCM 9.7
Central nervous system MOGGUVW 9.3
Central nervous system NMCG1 9
Central nervous system ONS76 10.2
Central nervous system SF126 8.8
Central nervous system SF295 9.3
Central nervous system SNB19 10
Central nervous system SNU1105 9.2
Central nervous system SNU201 9
Central nervous system SNU466 8.7
Central nervous system SNU489 8.6
Central nervous system SNU626 9.5
Central nervous system SNU738 9
Central nervous system SW1088 9.2
Central nervous system SW1783 9
Central nervous system T98G 9.4
Central nervous system TM31 9.3
Central nervous system U118MG 8.7
Central nervous system U138MG 9.3
Central nervous system U251MG 9.3
Central nervous system U87MG 9
Central nervous system YH13 9.6
Central nervous system YKG1 9.8
Endometrium AN3CA 8.8
Endometrium COLO684 9.8
Endometrium EFE184 9.6
Endometrium EN 9.9
Endometrium ESS1 8.9
Endometrium HEC108 8.9
Endometrium HEC151 9.2
Endometrium HEC1A 9.2
Endometrium HEC1B 9.7
Endometrium HEC251 9
Endometrium HEC265 9.2
Endometrium HEC50B 8.7
Endometrium HEC59 9.3
Endometrium HEC6 9.5
Endometrium ISHIKAWAHERAKLIO02ER 9.4
Endometrium JHUEM1 8.9
Endometrium JHUEM2 9.7
Endometrium JHUEM3 9.2
Endometrium KLE 8.6
Endometrium MFE280 9.5
Endometrium MFE296 9.7
Endometrium MFE319 9.4
Endometrium RL952 9.8
Endometrium SNGM 8.8
Endometrium SNU1077 9.3
Endometrium SNU685 9.3
Endometrium TEN 9
Haematopoietic and lymphoid 697 9.1
Haematopoietic and lymphoid A3KAW 9.5
Haematopoietic and lymphoid A4FUK 9
Haematopoietic and lymphoid ALLSIL 9
Haematopoietic and lymphoid AML193 9.4
Haematopoietic and lymphoid AMO1 9.9
Haematopoietic and lymphoid BCP1 8.7
Haematopoietic and lymphoid BDCM 9.1
Haematopoietic and lymphoid BL41 9.9
Haematopoietic and lymphoid BL70 10
Haematopoietic and lymphoid BV173 9.2
Haematopoietic and lymphoid CA46 9.5
Haematopoietic and lymphoid CI1 9.2
Haematopoietic and lymphoid CMK115 9.2
Haematopoietic and lymphoid CMK86 9.1
Haematopoietic and lymphoid CMK 9.3
Haematopoietic and lymphoid CMLT1 9
Haematopoietic and lymphoid COLO775 9.1
Haematopoietic and lymphoid DAUDI 8.9
Haematopoietic and lymphoid DB 9.2
Haematopoietic and lymphoid DEL 10
Haematopoietic and lymphoid DND41 8.4
Haematopoietic and lymphoid DOHH2 9.2
Haematopoietic and lymphoid EB1 8.9
Haematopoietic and lymphoid EB2 9
Haematopoietic and lymphoid EHEB 9.2
Haematopoietic and lymphoid EJM 8.9
Haematopoietic and lymphoid EM2 9.4
Haematopoietic and lymphoid EOL1 9.1
Haematopoietic and lymphoid F36P 8.8
Haematopoietic and lymphoid GA10 9.6
Haematopoietic and lymphoid GDM1 9.4
Haematopoietic and lymphoid GRANTA519 9.4
Haematopoietic and lymphoid HDLM2 9
Haematopoietic and lymphoid HDMYZ 9.3
Haematopoietic and lymphoid HEL9217 8.9
Haematopoietic and lymphoid HEL 9.3
Haematopoietic and lymphoid HH 9
Haematopoietic and lymphoid HL60 9.5
Haematopoietic and lymphoid HPBALL 8.8
Haematopoietic and lymphoid HS604T 8.9
Haematopoietic and lymphoid HS611T 9.1
Haematopoietic and lymphoid HS616T 8.9
Haematopoietic and lymphoid HS751T 8.8
Haematopoietic and lymphoid HT 9.4
Haematopoietic and lymphoid HTK 7.5
Haematopoietic and lymphoid HUNS1 9.2
Haematopoietic and lymphoid HUT102 9.6
Haematopoietic and lymphoid HUT78 8.8
Haematopoietic and lymphoid JEKO1 8.5
Haematopoietic and lymphoid JK1 9.9
Haematopoietic and lymphoid JM1 9.4
Haematopoietic and lymphoid JURKAT 9.5
Haematopoietic and lymphoid JURLMK1 9.3
Haematopoietic and lymphoid JVM2 9.9
Haematopoietic and lymphoid JVM3 9.6
Haematopoietic and lymphoid K562 8.8
Haematopoietic and lymphoid KARPAS299 8.4
Haematopoietic and lymphoid KARPAS422 9.3
Haematopoietic and lymphoid KARPAS620 9.8
Haematopoietic and lymphoid KASUMI1 9.6
Haematopoietic and lymphoid KASUMI2 8.8
Haematopoietic and lymphoid KASUMI6 9.2
Haematopoietic and lymphoid KCL22 9.5
Haematopoietic and lymphoid KE37 8.8
Haematopoietic and lymphoid KE97 8.8
Haematopoietic and lymphoid KG1 9.4
Haematopoietic and lymphoid KHM1B 10.4
Haematopoietic and lymphoid KIJK 9.6
Haematopoietic and lymphoid KMH2 9.3
Haematopoietic and lymphoid KMM1 9.4
Haematopoietic and lymphoid KMS11 10.4
Haematopoietic and lymphoid KMS12BM 9.2
Haematopoietic and lymphoid KMS18 9.5
Haematopoietic and lymphoid KMS20 10.3
Haematopoietic and lymphoid KMS21BM 9.8
Haematopoietic and lymphoid KMS26 9.5
Haematopoietic and lymphoid KMS27 9.2
Haematopoietic and lymphoid KMS28BM 9.9
Haematopoietic and lymphoid KMS34 9.4
Haematopoietic and lymphoid KO52 9.7
Haematopoietic and lymphoid KOPN8 7.9
Haematopoietic and lymphoid KU812 9.6
Haematopoietic and lymphoid KYO1 8
Haematopoietic and lymphoid L1236 9.3
Haematopoietic and lymphoid L363 10.6
Haematopoietic and lymphoid L428 9
Haematopoietic and lymphoid L540 8.7
Haematopoietic and lymphoid LAMA84 8.9
Haematopoietic and lymphoid LOUCY 9.3
Haematopoietic and lymphoid LP1 10.3
Haematopoietic and lymphoid M07E 9.5
Haematopoietic and lymphoid MC116 9.1
Haematopoietic and lymphoid ME1 8.1
Haematopoietic and lymphoid MEC1 9
Haematopoietic and lymphoid MEC2 8.9
Haematopoietic and lymphoid MEG01 8.9
Haematopoietic and lymphoid MHHCALL2 9.6
Haematopoietic and lymphoid MHHCALL3 9.4
Haematopoietic and lymphoid MHHCALL4 9.8
Haematopoietic and lymphoid MINO 8.8
Haematopoietic and lymphoid MJ 8.7
Haematopoietic and lymphoid MM1S 9.8
Haematopoietic and lymphoid MOLM13 8.9
Haematopoietic and lymphoid MOLM16 8.6
Haematopoietic and lymphoid MOLM6 9.7
Haematopoietic and lymphoid MOLP2 8.9
Haematopoietic and lymphoid MOLP8 10.3
Haematopoietic and lymphoid MOLT13 9.6
Haematopoietic and lymphoid MOLT16 9.3
Haematopoietic and lymphoid MOLT4 9
Haematopoietic and lymphoid MONOMAC1 9.1
Haematopoietic and lymphoid MONOMAC6 9.3
Haematopoietic and lymphoid MOTN1 9.6
Haematopoietic and lymphoid MUTZ5 9.3
Haematopoietic and lymphoid MV411 9.4
Haematopoietic and lymphoid NALM19 8.7
Haematopoietic and lymphoid NALM1 9.2
Haematopoietic and lymphoid NALM6 9.1
Haematopoietic and lymphoid NAMALWA 9.8
Haematopoietic and lymphoid NB4 9
Haematopoietic and lymphoid NCIH929 9.8
Haematopoietic and lymphoid NCO2 9
Haematopoietic and lymphoid NOMO1 9.3
Haematopoietic and lymphoid NUDHL1 8.1
Haematopoietic and lymphoid NUDUL1 9.9
Haematopoietic and lymphoid OCIAML2 8.5
Haematopoietic and lymphoid OCIAML3 9.3
Haematopoietic and lymphoid OCIAML5 9.1
Haematopoietic and lymphoid OCILY10 9.2
Haematopoietic and lymphoid OCILY19 8.9
Haematopoietic and lymphoid OCILY3 9.4
Haematopoietic and lymphoid OCIM1 9.1
Haematopoietic and lymphoid OPM2 10.9
Haematopoietic and lymphoid P12ICHIKAWA 9.7
Haematopoietic and lymphoid P31FUJ 9
Haematopoietic and lymphoid P3HR1 8.7
Haematopoietic and lymphoid PCM6 8.2
Haematopoietic and lymphoid PEER 9
Haematopoietic and lymphoid PF382 9.6
Haematopoietic and lymphoid PFEIFFER 9.2
Haematopoietic and lymphoid PL21 9.5
Haematopoietic and lymphoid RAJI 9
Haematopoietic and lymphoid RCHACV 9.1
Haematopoietic and lymphoid REC1 8.9
Haematopoietic and lymphoid REH 9.3
Haematopoietic and lymphoid RI1 7.8
Haematopoietic and lymphoid RL 9.2
Haematopoietic and lymphoid RPMI8226 9.8
Haematopoietic and lymphoid RPMI8402 9.5
Haematopoietic and lymphoid RS411 9.1
Haematopoietic and lymphoid SEM 9.1
Haematopoietic and lymphoid SET2 9.5
Haematopoietic and lymphoid SIGM5 9.7
Haematopoietic and lymphoid SKM1 9.6
Haematopoietic and lymphoid SKMM2 9.3
Haematopoietic and lymphoid SR786 9.7
Haematopoietic and lymphoid ST486 9.2
Haematopoietic and lymphoid SUDHL10 8.4
Haematopoietic and lymphoid SUDHL1 9.4
Haematopoietic and lymphoid SUDHL4 8.4
Haematopoietic and lymphoid SUDHL5 9.2
Haematopoietic and lymphoid SUDHL6 9.6
Haematopoietic and lymphoid SUDHL8 8.9
Haematopoietic and lymphoid SUPB15 9.4
Haematopoietic and lymphoid SUPHD1 9.7
Haematopoietic and lymphoid SUPM2 9.3
Haematopoietic and lymphoid SUPT11 9.1
Haematopoietic and lymphoid SUPT1 9.5
Haematopoietic and lymphoid TALL1 9.9
Haematopoietic and lymphoid TF1 8.5
Haematopoietic and lymphoid THP1 10
Haematopoietic and lymphoid TO175T 9.2
Haematopoietic and lymphoid TOLEDO 10
Haematopoietic and lymphoid U266B1 9.2
Haematopoietic and lymphoid U937 9.5
Haematopoietic and lymphoid UT7 9.9
Haematopoietic and lymphoid WSUDLCL2 8.9
Kidney 769P 8.9
Kidney 786O 8.9
Kidney A498 8.9
Kidney A704 8.7
Kidney ACHN 8.8
Kidney BFTC909 9.1
Kidney CAKI1 9.7
Kidney CAKI2 9.2
Kidney CAL54 8.5
Kidney KMRC1 9.2
Kidney KMRC20 9.7
Kidney KMRC2 8.9
Kidney KMRC3 9.3
Kidney OSRC2 9.4
Kidney RCC10RGB 9.2
Kidney SNU1272 9.4
Kidney SNU349 8.3
Kidney TUHR10TKB 9.1
Kidney TUHR14TKB 9.7
Kidney TUHR4TKB 9.3
Kidney VMRCRCW 8.9
Kidney VMRCRCZ 9.3
Large intestine C2BBE1 8.7
Large intestine CCK81 9.8
Large intestine CL11 9.2
Large intestine CL14 9.2
Large intestine CL34 9.3
Large intestine CL40 8.7
Large intestine COLO205 9.7
Large intestine COLO320 9.8
Large intestine COLO678 10.5
Large intestine CW2 9.3
Large intestine DLD1 9.1
Large intestine GP2D 9.3
Large intestine HCC56 10.4
Large intestine HCT116 9.1
Large intestine HCT15 9.4
Large intestine HS675T 9.1
Large intestine HS698T 9.1
Large intestine HT115 8.4
Large intestine HT29 9.4
Large intestine HT55 9.6
Large intestine KM12 9.2
Large intestine LOVO 9.1
Large intestine LS1034 9.3
Large intestine LS123 9.3
Large intestine LS180 9.3
Large intestine LS411N 9.3
Large intestine LS513 9.7
Large intestine MDST8 8.6
Large intestine NCIH508 9.8
Large intestine NCIH716 9.8
Large intestine NCIH747 10
Large intestine OUMS23 9.4
Large intestine RCM1 9.6
Large intestine RKO 9
Large intestine SKCO1 9.9
Large intestine SNU1040 9.1
Large intestine SNU1197 9.2
Large intestine SNU175 9
Large intestine SNU283 9.7
Large intestine SNU407 10.3
Large intestine SNU503 9.4
Large intestine SNU61 9.6
Large intestine SNU81 9.3
Large intestine SNUC1 9.4
Large intestine SNUC2A 9.8
Large intestine SNUC4 9.4
Large intestine SNUC5 9.5
Large intestine SW1116 9.2
Large intestine SW1417 9.2
Large intestine SW1463 9.3
Large intestine SW403 9.7
Large intestine SW480 8.2
Large intestine SW48 9.2
Large intestine SW620 8.8
Large intestine SW837 9.6
Large intestine SW948 9.5
Large intestine T84 9.9
Liver ALEXANDERCELLS 8.9
Liver C3A 8.7
Liver HEP3B217 9.7
Liver HEPG2 8.7
Liver HLE 8.6
Liver HLF 9.1
Liver HUH1 9.9
Liver HUH6 8.9
Liver HUH7 8.9
Liver JHH1 9.7
Liver JHH2 9.1
Liver JHH4 9.6
Liver JHH5 9.8
Liver JHH6 8.8
Liver JHH7 9.3
Liver LI7 9.4
Liver PLCPRF5 8.8
Liver SKHEP1 9
Liver SNU182 7.8
Liver SNU387 9.2
Liver SNU398 9.3
Liver SNU423 8.9
Liver SNU449 9.3
Liver SNU475 9.8
Liver SNU761 9.5
Liver SNU878 8.9
Liver SNU886 9
Lung A549 8.8
Lung ABC1 9.8
Lung BEN 10.3
Lung CAL12T 8.7
Lung CALU1 9.1
Lung CALU3 9.6
Lung CALU6 9.5
Lung CHAGOK1 10.1
Lung COLO668 9.5
Lung COLO699 9.3
Lung CORL105 9.4
Lung CORL23 9
Lung CORL24 9.9
Lung CORL279 9.1
Lung CORL311 9.5
Lung CORL47 8.9
Lung CORL51 9.5
Lung CORL88 9.5
Lung CORL95 9.5
Lung CPCN 9.4
Lung DMS114 10.8
Lung DMS153 10.5
Lung DMS273 9
Lung DMS454 9.5
Lung DMS53 9.5
Lung DMS79 9.8
Lung DV90 9.3
Lung EBC1 8.8
Lung EPLC272H 8.6
Lung HARA 9
Lung HCC1171 10.8
Lung HCC1195 9.1
Lung HCC15 9.2
Lung HCC2279 8.5
Lung HCC2935 9.7
Lung HCC33 9.9
Lung HCC366 8.1
Lung HCC4006 9.4
Lung HCC44 9.6
Lung HCC78 9.9
Lung HCC827 9
Lung HCC95 8.4
Lung HLC1 9.5
Lung HLFA 9.1
Lung HS229T 8.9
Lung HS618T 9.2
Lung IALM 9.6
Lung KNS62 9.1
Lung LC1F 10
Lung LC1SQSF 9.8
Lung LCLC103H 8.9
Lung LCLC97TM1 9.9
Lung LK2 9.3
Lung LOUNH91 8.9
Lung LU65 10
Lung LU99 9.4
Lung LUDLU1 9.9
Lung LXF289 9.5
Lung MORCPR 9.9
Lung NCIH1048 10.2
Lung NCIH1092 10.1
Lung NCIH1105 10
Lung NCIH1155 9.3
Lung NCIH1184 10.2
Lung NCIH1299 9.2
Lung NCIH1339 9.2
Lung NCIH1341 10.1
Lung NCIH1355 9.2
Lung NCIH1373 9.5
Lung NCIH1385 10.3
Lung NCIH1395 8.8
Lung NCIH1435 9.5
Lung NCIH1436 9.6
Lung NCIH1437 9.1
Lung NCIH146 9.1
Lung NCIH1563 8.9
Lung NCIH1568 9
Lung NCIH1573 9.9
Lung NCIH1581 9.6
Lung NCIH1618 10.7
Lung NCIH1623 10.1
Lung NCIH1648 9.3
Lung NCIH1650 9
Lung NCIH1651 9.1
Lung NCIH1666 10.2
Lung NCIH1693 9.1
Lung NCIH1694 10.8
Lung NCIH1703 9.3
Lung NCIH1734 10.1
Lung NCIH1755 9.6
Lung NCIH1781 10.1
Lung NCIH1792 9.3
Lung NCIH1793 9.1
Lung NCIH1836 9.9
Lung NCIH1838 10.1
Lung NCIH1869 9.7
Lung NCIH1876 11.1
Lung NCIH1915 9.2
Lung NCIH1930 9.7
Lung NCIH1944 9.3
Lung NCIH1963 10.6
Lung NCIH196 9.7
Lung NCIH1975 9.3
Lung NCIH2009 9.9
Lung NCIH2023 9.4
Lung NCIH2029 9.9
Lung NCIH2030 9.6
Lung NCIH2066 10.3
Lung NCIH2081 10.2
Lung NCIH2085 9.2
Lung NCIH2087 9.8
Lung NCIH209 9.8
Lung NCIH2106 9.2
Lung NCIH2110 10.3
Lung NCIH211 8.9
Lung NCIH2122 9.7
Lung NCIH2126 9.8
Lung NCIH2141 10
Lung NCIH2170 10
Lung NCIH2171 9.3
Lung NCIH2172 9.3
Lung NCIH2196 9.6
Lung NCIH2227 9.7
Lung NCIH2228 9.9
Lung NCIH226 9.3
Lung NCIH2286 9.6
Lung NCIH2291 9.6
Lung NCIH2342 10.6
Lung NCIH2347 9.7
Lung NCIH23 10.3
Lung NCIH2405 9.4
Lung NCIH2444 8.7
Lung NCIH292 9
Lung NCIH322 10
Lung NCIH3255 9.3
Lung NCIH358 9.8
Lung NCIH441 9.5
Lung NCIH446 9.8
Lung NCIH460 9.9
Lung NCIH510 9.7
Lung NCIH520 9.4
Lung NCIH522 9.5
Lung NCIH524 9.2
Lung NCIH526 10.6
Lung NCIH596 9.7
Lung NCIH647 9.2
Lung NCIH650 8.8
Lung NCIH661 9.1
Lung NCIH69 9.7
Lung NCIH727 9.1
Lung NCIH810 10.6
Lung NCIH82 9.3
Lung NCIH838 9.5
Lung NCIH841 9.8
Lung NCIH854 9.4
Lung NCIH889 9.5
Lung PC14 8.9
Lung RERFLCAD1 9.6
Lung RERFLCAD2 9.2
Lung RERFLCAI 9.4
Lung RERFLCKJ 10.5
Lung RERFLCMS 9.3
Lung RERFLCSQ1 9.1
Lung SBC5 9.9
Lung SCLC21H 9.7
Lung SHP77 9.9
Lung SKLU1 8.9
Lung SKMES1 9.1
Lung SQ1 9.2
Lung SW1271 8.9
Lung SW1573 9.5
Lung SW900 9.7
Lung VMRCLCD 9.7
Lung VMRCLCP 9.6
Oesophagus COLO680N 9.1
Oesophagus ECGI10 10
Oesophagus KYSE140 9.4
Oesophagus KYSE150 9.3
Oesophagus KYSE180 9.6
Oesophagus KYSE270 9.1
Oesophagus KYSE30 10.1
Oesophagus KYSE410 9.4
Oesophagus KYSE450 9.5
Oesophagus KYSE510 9.9
Oesophagus KYSE520 9.1
Oesophagus KYSE70 9.1
Oesophagus OE19 10.1
Oesophagus OE33 9.4
Oesophagus TE10 9.3
Oesophagus TE11 9.4
Oesophagus TE14 9.8
Oesophagus TE15 9.7
Oesophagus TE1 9.8
Oesophagus TE4 9.4
Oesophagus TE5 9.6
Oesophagus TE6 9.6
Oesophagus TE8 9.7
Oesophagus TE9 9.2
Oesophagus TT 10.4
Ovary 59M 8.7
Ovary A2780 9.5
Ovary CAOV3 8
Ovary CAOV4 10.4
Ovary COLO704 10.5
Ovary COV318 10
Ovary COV362 9.6
Ovary COV434 9.1
Ovary COV504 9.4
Ovary COV644 9.4
Ovary EFO21 9.8
Ovary EFO27 9.3
Ovary ES2 9
Ovary FUOV1 9.8
Ovary HEYA8 8.4
Ovary HS571T 9
Ovary IGROV1 9
Ovary JHOC5 8.8
Ovary JHOM1 8.7
Ovary JHOM2B 9.9
Ovary JHOS2 9.5
Ovary JHOS4 9.7
Ovary KURAMOCHI 10
Ovary MCAS 9.5
Ovary NIHOVCAR3 9.4
Ovary OAW28 9
Ovary OAW42 9.4
Ovary OC314 9.2
Ovary OC316 9.1
Ovary ONCODG1 8.6
Ovary OV56 9.3
Ovary OV7 9
Ovary OV90 9.5
Ovary OVCAR4 9.8
Ovary OVCAR8 8.7
Ovary OVISE 9.3
Ovary OVK18 9.4
Ovary OVKATE 9.9
Ovary OVMANA 9.4
Ovary OVSAHO 9.1
Ovary OVTOKO 8.7
Ovary RMGI 8.1
Ovary RMUGS 9.2
Ovary SKOV3 9.3
Ovary SNU119 9.9
Ovary SNU840 9.6
Ovary SNU8 9.2
Ovary TOV112D 9.5
Ovary TOV21G 8.9
Ovary TYKNU 9
Pancreas ASPC1 9.6
Pancreas BXPC3 8.5
Pancreas CAPAN1 9.4
Pancreas CAPAN2 9.6
Pancreas CFPAC1 9.4
Pancreas DANG 8.9
Pancreas HPAC 10.1
Pancreas HPAFII 8.9
Pancreas HS766T 9.5
Pancreas HUPT3 9.4
Pancreas HUPT4 8.4
Pancreas KCIMOH1 9.4
Pancreas KLM1 9.2
Pancreas KP2 9.9
Pancreas KP3 9.4
Pancreas KP4 9.3
Pancreas L33 10.1
Pancreas MIAPACA2 10
Pancreas PANC0203 9.9
Pancreas PANC0213 9.8
Pancreas PANC0327 9.1
Pancreas PANC0403 9.6
Pancreas PANC0504 9.1
Pancreas PANC0813 9.1
Pancreas PANC1005 9.6
Pancreas PANC1 9.5
Pancreas PATU8902 8.9
Pancreas PATU8988S 9.6
Pancreas PATU8988T 8.9
Pancreas PK1 9.3
Pancreas PK45H 9.3
Pancreas PK59 8.8
Pancreas PL45 9.7
Pancreas PSN1 9.6
Pancreas QGP1 10.3
Pancreas SNU213 9.2
Pancreas SNU324 10.5
Pancreas SNU410 9.2
Pancreas SU8686 9.5
Pancreas SUIT2 9.3
Pancreas SW1990 9.1
Pancreas T3M4 9.6
Pancreas TCCPAN2 9.3
Pancreas YAPC 9.3
Pleura ACCMESO1 8.3
Pleura DM3 9
Pleura ISTMES1 9.9
Pleura ISTMES2 9.4
Pleura JL1 9.4
Pleura MPP89 9.1
Pleura MSTO211H 8.8
Pleura NCIH2052 8.9
Pleura NCIH2452 9.1
Pleura NCIH28 10.1
Prostate 22RV1 9.7
Prostate DU145 9.3
Prostate LNCAPCLONEFGC 9.6
Prostate MDAPCA2B 9.8
Prostate NCIH660 10.4
Prostate PC3 9
Prostate VCAP 9.3
Salivary gland A253 9.2
Salivary gland YD15 9.3
Skin A101D 9.2
Skin A2058 9.5
Skin A375 9.3
Skin C32 9.1
Skin CHL1 8.8
Skin CJM 8.9
Skin COLO679 9.8
Skin COLO741 8.9
Skin COLO783 8.6
Skin COLO792 7.9
Skin COLO800 9.2
Skin COLO818 8.8
Skin COLO829 9.3
Skin COLO849 9
Skin G361 9.5
Skin GRM 9.2
Skin HMCB 9.2
Skin HS294T 8.8
Skin HS600T 9
Skin HS688AT 9
Skin HS695T 9.7
Skin HS839T 9.3
Skin HS852T 9.7
Skin HS895T 8.7
Skin HS934T 9
Skin HS936T 9.2
Skin HS939T 9.5
Skin HS940T 9
Skin HS944T 8.6
Skin HT144 9.2
Skin IGR1 8.9
Skin IGR37 8.8
Skin IGR39 8.8
Skin IPC298 8.5
Skin K029AX 9.4
Skin LOXIMVI 8.9
Skin MALME3M 9
Skin MDAMB435S 8.3
Skin MELHO 8.7
Skin MELJUSO 8.6
Skin MEWO 9.1
Skin RPMI7951 8.8
Skin RVH421 9.1
Skin SH4 9.3
Skin SKMEL1 8.8
Skin SKMEL24 9
Skin SKMEL28 8.9
Skin SKMEL2 9
Skin SKMEL30 9.1
Skin SKMEL31 8.5
Skin SKMEL3 8.8
Skin SKMEL5 9.1
Skin UACC257 8.8
Skin UACC62 9.2
Skin WM115 9.3
Skin WM1799 9.3
Skin WM2664 8.6
Skin WM793 9.1
Skin WM88 9.6
Skin WM983B 8.6
Small intestine HUTU80 9.6
Soft tissue A204 9.2
Soft tissue G401 8.7
Soft tissue G402 9.3
Soft tissue GCT 8.8
Soft tissue HS729 10.1
Soft tissue HT1080 9.1
Soft tissue KYM1 9.5
Soft tissue MESSA 8.9
Soft tissue RD 9.6
Soft tissue RH30 8.7
Soft tissue RH41 9.4
Soft tissue RKN 8.9
Soft tissue S117 9.1
Soft tissue SJRH30 9.4
Soft tissue SKLMS1 8.8
Soft tissue SKUT1 9.2
Soft tissue TE125T 8.7
Soft tissue TE159T 9.2
Soft tissue TE441T 9.8
Soft tissue TE617T 9.3
Stomach 2313287 9.9
Stomach AGS 9.8
Stomach AZ521 9.2
Stomach ECC10 10
Stomach ECC12 10.5
Stomach FU97 9.1
Stomach GCIY 9.6
Stomach GSS 9.4
Stomach GSU 9.2
Stomach HGC27 9.5
Stomach HS746T 8.8
Stomach HUG1N 9.6
Stomach IM95 9.2
Stomach KATOIII 8.8
Stomach KE39 9.5
Stomach LMSU 9.4
Stomach MKN1 9
Stomach MKN45 9.2
Stomach MKN74 9.8
Stomach MKN7 9.2
Stomach NCCSTCK140 9.6
Stomach NCIN87 9.7
Stomach NUGC2 9
Stomach NUGC3 9.1
Stomach NUGC4 9.4
Stomach OCUM1 9.5
Stomach RERFGC1B 10.5
Stomach SH10TC 8.8
Stomach SNU16 9.1
Stomach SNU1 9.7
Stomach SNU216 9.3
Stomach SNU520 9.4
Stomach SNU5 8.8
Stomach SNU601 8.9
Stomach SNU620 9.3
Stomach SNU668 9.3
Stomach SNU719 8.6
Stomach TGBC11TKB 9.8
Thyroid 8305C 8.5
Thyroid 8505C 8.5
Thyroid BCPAP 8.5
Thyroid BHT101 10.2
Thyroid CAL62 9.2
Thyroid CGTHW1 9
Thyroid FTC133 8.7
Thyroid FTC238 8.9
Thyroid ML1 9.7
Thyroid SW579 8.9
Thyroid TT2609C02 8.9
Thyroid TT 10.2
Upper aerodigestive tract BHY 9.3
Upper aerodigestive tract BICR16 7.9
Upper aerodigestive tract BICR18 8.6
Upper aerodigestive tract BICR22 9.3
Upper aerodigestive tract BICR31 8.8
Upper aerodigestive tract BICR56 9.4
Upper aerodigestive tract BICR6 9.2
Upper aerodigestive tract CAL27 9.3
Upper aerodigestive tract CAL33 9.2
Upper aerodigestive tract DETROIT562 8.9
Upper aerodigestive tract FADU 9.4
Upper aerodigestive tract HS840T 8.9
Upper aerodigestive tract HSC2 8.8
Upper aerodigestive tract HSC3 8.9
Upper aerodigestive tract HSC4 10.2
Upper aerodigestive tract PECAPJ15 9.6
Upper aerodigestive tract PECAPJ34CLONEC12 8.6
Upper aerodigestive tract PECAPJ41CLONED2 8.9
Upper aerodigestive tract PECAPJ49 7.6
Upper aerodigestive tract SCC15 8.8
Upper aerodigestive tract SCC25 8.9
Upper aerodigestive tract SCC4 8.7
Upper aerodigestive tract SCC9 9.5
Upper aerodigestive tract SNU1076 9
Upper aerodigestive tract SNU1214 9.2
Upper aerodigestive tract SNU46 9.2
Upper aerodigestive tract SNU899 8.9
Upper aerodigestive tract YD10B 9.6
Upper aerodigestive tract YD38 9.1
Upper aerodigestive tract YD8 8.8
Urinary tract 5637 8.5
Urinary tract 639V 9
Urinary tract 647V 9.4
Urinary tract BC3C 8.8
Urinary tract BFTC905 9.2
Urinary tract CAL29 8.9
Urinary tract HS172T 8.6
Urinary tract HT1197 8.5
Urinary tract HT1376 9.3
Urinary tract J82 9.1
Urinary tract JMSU1 10.2
Urinary tract KMBC2 9.3
Urinary tract KU1919 9.4
Urinary tract RT11284 9
Urinary tract RT112 9
Urinary tract RT4 9.4
Urinary tract SCABER 9.5
Urinary tract SW1710 9.1
Urinary tract SW780 10.1
Urinary tract T24 8.7
Urinary tract TCCSUP 8.6
Urinary tract UMUC1 8.6
Urinary tract UMUC3 9.4
Urinary tract VMCUB1 10.1
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 12.4
Adrenal gland 12
Appendix 12.1
Bone marrow 9.3
Breast 18.1
Cerebral cortex 25
Cervix, uterine 21.3
Colon 10.3
Duodenum 8.9
Endometrium 23.8
Epididymis 14.7
Esophagus 10.8
Fallopian tube 19.4
Gallbladder 13.8
Heart muscle 7.7
Kidney 13.8
Liver 4.2
Lung 14.1
Lymph node 11.2
Ovary 27.9
Pancreas 2.1
Parathyroid gland 37.3
Placenta 14.6
Prostate 21.4
Rectum 12
Salivary gland 5.1
Seminal vesicle 19.8
Skeletal muscle 6
Skin 15.9
Small intestine 10.5
Smooth muscle 18.2
Spleen 13.2
Stomach 10.2
Testis 15.7
Thyroid gland 28.1
Tonsil 9.8
Urinary bladder 11
> Text Mining based Expression
 
PMID Expression Cancer Evidence
27064257altered expressionHepatocellular CarcinomaSTV analysis found a significant association with replication timing and identified known (CDKN2A, CCND1, APC, and TERT) and new (ASH1L, NCOR1, and MACROD2) cancer-related genes that were recurrently affected by STVs, leading to altered expression.
25238203OverexpressionThyroid Gland Follicular CarcinomaHere we show that miR-142-3p is downregulated in FTAs, FTCs, and FVPTCs.Moreover, this microRNA was able to downregulate the expression of ASH1L and MLL1, by direct and indirect mechanisms, respectively.
24670651altered expressionEsophageal Squamous Cell CarcinomaMoreover, we have found that several important histone regulator genes (MLL2 (also called KMT2D), ASH1L, MLL3 (KMT2C), SETD1B, CREBBP and EP300) are frequently altered in ESCC.
18277965Overexpression (copy number gain)Hepatocellular CarcinomaCytogenetics of hepatocellular carcinoma and adenoma have revealed gains of chromosome 1q as a significant differentiating factor. Gene set enrichment analysis detected groups of upregulated genes located in chromosome bands 1q22-42 seen also as the most frequently gained regions by comparative genomic hybridisation. Comparison of significance analysis of microarray and gene set enrichment analysis narrowed down the number of dysregulated genes to 18, with 7 genes localised on 1q22 (SCAMP3, IQGAP3, PYGO2, GPATC4, ASH1L, APOA1BP, and CCT3).
26292256Overexpression; copy number gain; mutationBreast Carcinoma; Thyroid Gland Carcinoma; Lung Carcinoma; Cervical CarcinomaIn breast cancer, 27 percent of aggressive, basal-like breast cancers have high-level copy number amplifications of theASH1Lgene. Moreover, high levels of ASH1L mRNA are associated with shorter survival in breast cancer patients. In thyroid cancer, ASH1L is overexpressed in tumor-specific truncated forms and is downregulated by a tumor suppressor microRNA. Amplifications of ASH1L are found in a variety of other tumors, such as lung and uterine cancer, while mutations in ASH1L have been identified in gastric cancer, colorectal cancer, esophageal squamous cell cancer, and lung cancer.
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
Cancer Full Name # Sample R P % Loss % Neutral % Gain Status
BLCABladder urothelial carcinoma4040.4762.89e-245.948.845.3Gain
BRCABreast invasive carcinoma10750.3744.32e-371.424.774Gain
CESCCervical and endocervical cancers2920.3867.98e-122.444.253.4Gain
COADColon adenocarcinoma4490.3622.6e-159.470.420.3Neutral
ESCAEsophageal carcinoma1830.4511.47e-104.448.147.5Gain
GBMGlioblastoma multiforme1470.2750.0007522.776.221.1Neutral
HNSCHead and Neck squamous cell carcinoma5140.2854.41e-117.267.725.1Neutral
KIRCKidney renal clear cell carcinoma5250.2281.32e-076.581.711.8Neutral
KIRPKidney renal papillary cell carcinoma2880.2355.51e-056.687.85.6Neutral
LAMLAcute Myeloid Leukemia1660.1140.145098.81.2Neutral
LGGBrain Lower Grade Glioma5130.0320.4711.990.87.2Neutral
LIHCLiver hepatocellular carcinoma3640.4774.36e-220.523.675.8Gain
LUADLung adenocarcinoma5120.4711.23e-291.624.474Gain
LUSCLung squamous cell carcinoma4980.4611.27e-274.243.252.6Gain
OVOvarian serous cystadenocarcinoma3000.4725.02e-18235.762.3Gain
PAADPancreatic adenocarcinoma1770.2510.0007673.463.832.8Neutral
PCPGPheochromocytoma and Paraganglioma1620.3777.4e-078.675.316Neutral
PRADProstate adenocarcinoma4910.1912.03e-052.4907.5Neutral
READRectum adenocarcinoma1640.2730.0004077.963.428.7Neutral
SARCSarcoma2550.4343.72e-136.754.938.4Gain
SKCMSkin Cutaneous Melanoma3670.4828.63e-233.841.155Gain
STADStomach adenocarcinoma4130.424.31e-192.96136.1Gain
TGCTTesticular Germ Cell Tumors1500.3521.02e-050.75445.3Gain
THCAThyroid carcinoma4970.2131.72e-060.893.85.4Neutral
THYMThymoma1190.3190.000407079.820.2Neutral
UCECUterine Corpus Endometrial Carcinoma5370.4715.84e-310.452.547.1Gain
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
BLCABladder urothelial carcinoma-0.3144.78e-1117408-0.0060.525NS/NA
BRCABreast invasive carcinoma-0.2352.92e-1283785-0.0010.0149NS/NA
CESCCervical and endocervical cancers-0.2652.42e-063306NANANS/NA
COADColon adenocarcinoma-0.2978.89e-08192970.0040.0961NS/NA
ESCAEsophageal carcinoma-0.2380.0008729185NANANS/NA
GBMGlioblastoma multiforme-0.3390.00597164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.2513.31e-09205220.0021.31e-07NS/NA
KIRCKidney renal clear cell carcinoma-0.2242.97e-05243190.0155.92e-15NS/NA
KIRPKidney renal papillary cell carcinoma-0.3392.41e-09232750.0042e-04NS/NA
LAMLAcute Myeloid Leukemia-0.1270.09990170NANANS/NA
LGGBrain Lower Grade Glioma-0.1937.54e-060530NANANS/NA
LIHCLiver hepatocellular carcinoma-0.2664.61e-0841373-0.0080.542NS/NA
LUADLung adenocarcinoma-0.2248.62e-0721456-0.0050.758NS/NA
LUSCLung squamous cell carcinoma-0.2231.25e-058370NANANS/NA
OVOvarian serous cystadenocarcinoma-0.50.17809NANANS/NA
PAADPancreatic adenocarcinoma-0.1740.01854179NANANS/NA
PCPGPheochromocytoma and Paraganglioma-0.3528.92e-073184NANANS/NA
PRADProstate adenocarcinoma-0.2751.32e-1035498-0.0050.00298NS/NA
READRectum adenocarcinoma-0.4691.03e-06299NANANS/NA
SARCSarcoma-0.3372.54e-080263NANANS/NA
SKCMSkin Cutaneous Melanoma-0.3571.41e-151471NANANS/NA
STADStomach adenocarcinoma-0.2613.63e-070372NANANS/NA
TGCTTesticular Germ Cell Tumors-0.2420.002360156NANANS/NA
THCAThyroid carcinoma-0.1060.0121505090.0020.465NS/NA
THYMThymoma-0.5371.76e-102120NANANS/NA
UCECUterine Corpus Endometrial Carcinoma-0.2495.82e-0834431-0.0150.0795NS/NA
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Level Level Name
Adrenal gland 2 Medium
Appendix 0 Not detected
Bone marrow 1 Low
Bronchus 2 Medium
Caudate 2 Medium
Cerebellum 0 Not detected
Cerebral cortex 1 Low
Cervix, uterine 2 Medium
Colon 1 Low
Duodenum 0 Not detected
Endometrium 0 Not detected
Epididymis 2 Medium
Esophagus 2 Medium
Fallopian tube 2 Medium
Gallbladder 2 Medium
Heart muscle 0 Not detected
Hippocampus 0 Not detected
Kidney 0 Not detected
Liver 0 Not detected
Lung 2 Medium
Lymph node 0 Not detected
Nasopharynx 2 Medium
Oral mucosa 1 Low
Ovary 1 Low
Pancreas 3 High
Parathyroid gland 2 Medium
Placenta 3 High
Prostate 1 Low
Rectum 1 Low
Salivary gland 2 Medium
Seminal vesicle 0 Not detected
Skeletal muscle 0 Not detected
Skin 2 Medium
Small intestine 0 Not detected
Smooth muscle 0 Not detected
Soft tissue 0 Not detected
Spleen 0 Not detected
Stomach 0 Not detected
Testis 2 Medium
Thyroid gland 0 Not detected
Tonsil 0 Not detected
Urinary bladder 2 Medium
Vagina 1 Low
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
BLCABladder urothelial carcinoma1280.7NS24476821
BRCABreast invasive carcinoma5211.7e-06Significant23000897
COADColon adenocarcinoma1490.0017Significant22810696
GBMGlioblastoma multiforme1570.03Significant26824661
HNSCHead and Neck squamous cell carcinoma2792.39e-08Significant25631445
KIRPKidney renal papillary cell carcinoma1610.282NS26536169
LGGBrain Lower Grade Glioma5132.73e-05Significant26824661
LUADLung adenocarcinoma2300.0151Significant25079552
LUSCLung squamous cell carcinoma1780.234NS22960745
OVOvarian serous cystadenocarcinoma2870.0234Significant21720365
PRADProstate adenocarcinoma3339.45e-06Significant26544944
READRectum adenocarcinoma670.236NS22810696
SKCMSkin Cutaneous Melanoma3156.09e-05Significant26091043
STADStomach adenocarcinoma2777.32e-07Significant25079317
THCAThyroid carcinoma3910.106NS25417114
UCECUterine Corpus Endometrial Carcinoma2320.397NS23636398
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
BLCABladder urothelial carcinoma405 1.0180.936NS
BRCABreast invasive carcinoma1079 1.360.195NS
CESCCervical and endocervical cancers291 1.6780.15NS
COADColon adenocarcinoma439 0.7670.396NS
ESCAEsophageal carcinoma184 0.8330.54NS
GBMGlioblastoma multiforme158 0.8360.477NS
HNSCHead and Neck squamous cell carcinoma518 0.7760.198NS
KIRCKidney renal clear cell carcinoma531 0.2715.15e-08Longer
KIRPKidney renal papillary cell carcinoma287 1.7290.191NS
LAMLAcute Myeloid Leukemia149 0.6520.142NS
LGGBrain Lower Grade Glioma511 0.5740.0367Longer
LIHCLiver hepatocellular carcinoma365 0.9690.902NS
LUADLung adenocarcinoma502 0.6790.0797NS
LUSCLung squamous cell carcinoma494 0.9480.778NS
OVOvarian serous cystadenocarcinoma303 0.8430.433NS
PAADPancreatic adenocarcinoma177 1.3920.233NS
PCPGPheochromocytoma and Paraganglioma179 1553505149.6540.0501NS
PRADProstate adenocarcinoma497 0.9670.979NS
READRectum adenocarcinoma159 0.7980.73NS
SARCSarcoma259 1.0140.965NS
SKCMSkin Cutaneous Melanoma459 1.0440.825NS
STADStomach adenocarcinoma388 0.9630.869NS
TGCTTesticular Germ Cell Tumors134 1.0030.998NS
THCAThyroid carcinoma500 1.4240.642NS
THYMThymoma119 2.0910.385NS
UCECUterine Corpus Endometrial Carcinoma543 1.6510.115NS
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
BLCABladder urothelial carcinoma406 0.0470.35NS
BRCABreast invasive carcinoma1071 -0.0310.314NS
CESCCervical and endocervical cancers167 -0.0110.891NS
COADColon adenocarcinoma445 0.0640.178NS
ESCAEsophageal carcinoma162 -0.0740.351NS
HNSCHead and Neck squamous cell carcinoma448 -0.0070.882NS
KIRCKidney renal clear cell carcinoma531 -0.2081.35e-06Lower
KIRPKidney renal papillary cell carcinoma260 0.0370.552NS
LIHCLiver hepatocellular carcinoma347 0.0630.243NS
LUADLung adenocarcinoma507 -0.0380.392NS
LUSCLung squamous cell carcinoma497 0.0160.721NS
OVOvarian serous cystadenocarcinoma302 0.0240.677NS
PAADPancreatic adenocarcinoma176 0.0020.978NS
READRectum adenocarcinoma156 0.0950.236NS
SKCMSkin Cutaneous Melanoma410 -0.0380.449NS
STADStomach adenocarcinoma392 0.0670.185NS
TGCTTesticular Germ Cell Tumors81 -0.1370.222NS
THCAThyroid carcinoma499 -0.0010.986NS
UCECUterine Corpus Endometrial Carcinoma501 -0.0250.58NS
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
CESCCervical and endocervical cancers272 -0.0630.297NS
HNSCHead and Neck squamous cell carcinoma498 0.0680.129NS
KIRCKidney renal clear cell carcinoma525 -0.2184.84e-07Lower
LGGBrain Lower Grade Glioma514 -0.1680.000131Lower
LIHCLiver hepatocellular carcinoma366 0.0470.37NS
OVOvarian serous cystadenocarcinoma296 -0.0750.201NS
PAADPancreatic adenocarcinoma176 -0.0240.748NS
STADStomach adenocarcinoma406 -0.0390.437NS
UCECUterine Corpus Endometrial Carcinoma534 0.0820.0587NS
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for ASH1L.
Summary
SymbolASH1L
NameASH1 like histone lysine methyltransferase
Aliases huASH1; ASH1L1; KMT2H; ASH11; ASH1-like protein; absent small and homeotic disks protein 1 homolog; lysine N ......
Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
PMID Cancer Hierarchy Gene Relation to CR Evidence
25238203Thyroid Gland Follicular CarcinomapartnermiR-142-3pNegative correlationConsistently, an inverse correlation between miR-142-3p expression and ASH1L and MLL1 proteins was found in thyroid follicular adenomas and carcinomas.