CR2Cancer

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00622 SPRY domain

Function

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write cofactor	Histone methylation	#	#	21285357

> Gene Ontology [ TOP ]
Biological Process	GO:0006479 protein methylation GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0032259 methylation GO:0034968 histone lysine methylation GO:0043414 macromolecule methylation GO:0043627 response to estrogen GO:0051568 histone H3-K4 methylation GO:1904837 beta-catenin-TCF complex assembly
Molecular Function	GO:0003682 chromatin binding GO:0008013 beta-catenin binding GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity GO:0042800 histone methyltransferase activity (H3-K4 specific) GO:1990188 euchromatin binding
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0005719 nuclear euchromatin GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0044454 nuclear chromosome part GO:0044665 MLL1/2 complex GO:0044666 MLL3/4 complex GO:0048188 Set1C/COMPASS complex GO:0071339 MLL1 complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-1266738: Developmental Biology R-HSA-201722: Formation of the beta-catenin R-HSA-3214841: PKMTs methylate histone lysines R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex
R-HSA-1266738: Developmental Biology
R-HSA-201722: Formation of the beta-catenin
R-HSA-3214841: PKMTs methylate histone lysines
R-HSA-162582: Signal Transduction
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5518833	c.542G>A	p.R181Q	Substitution - Missense	Biliary_tract
COSM1099541	c.1666G>T	p.D556Y	Substitution - Missense	Skin
COSM750496	c.1405C>A	p.H469N	Substitution - Missense	Lung
COSM367496	c.1275C>G	p.I425M	Substitution - Missense	Lung
COSM1099539	c.1453G>A	p.V485I	Substitution - Missense	Stomach
COSM4519538	c.1015G>A	p.D339N	Substitution - Missense	Skin
COSM4996959	c.775C>T	p.Q259*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM750497	c.748G>T	p.D250Y	Substitution - Missense	Lung
COSM5998104	c.916G>T	p.G306W	Substitution - Missense	Prostate
COSM30719	c.175G>A	p.E59K	Substitution - Missense	Lung
COSM3899938	c.1478C>A	p.P493H	Substitution - Missense	Stomach
COSM3899937	c.1356T>C	p.G452G	Substitution - coding silent	Stomach
COSM3899936	c.975T>C	p.L325L	Substitution - coding silent	Stomach
COSM4998098	c.125C>A	p.P42H	Substitution - Missense	Pancreas
COSM486418	c.402-1G>T	p.?	Unknown	Kidney
COSM3648805	c.474C>T	p.F158F	Substitution - coding silent	Skin
COSM1099535	c.620G>A	p.C207Y	Substitution - Missense	Endometrium
COSM5359022	c.777+2T>C	p.?	Unknown	Large_intestine
COSM750499	c.214G>A	p.G72S	Substitution - Missense	Lung
COSM4606887	c.1862G>A	p.R621K	Substitution - Missense	Adrenal_gland
COSM346054	c.1244G>C	p.G415A	Substitution - Missense	Lung
COSM5998104	c.916G>T	p.G306W	Substitution - Missense	Prostate
COSM1099542	c.1702C>A	p.L568M	Substitution - Missense	Endometrium
COSM1099536	c.768T>G	p.L256L	Substitution - coding silent	Endometrium
COSM374842	c.1371C>T	p.S457S	Substitution - coding silent	Lung
COSM274058	c.1005G>A	p.P335P	Substitution - coding silent	Large_intestine
COSM1099531	c.231A>T	p.E77D	Substitution - Missense	Endometrium
COSM1245563	c.1768_1771delACTT	p.Y591fs*3	Deletion - Frameshift	Oesophagus
COSM1456878	c.1316G>A	p.G439D	Substitution - Missense	Large_intestine
COSM3648807	c.595C>T	p.P199S	Substitution - Missense	Skin
COSM3382243	c.1594A>T	p.S532C	Substitution - Missense	Pancreas
COSM4795580	c.1585G>A	p.A529T	Substitution - Missense	Liver
COSM4753075	c.976C>A	p.P326T	Substitution - Missense	Stomach
COSM73747	c.290C>G	p.T97S	Substitution - Missense	Ovary
COSM4753076	c.1447G>C	p.G483R	Substitution - Missense	Stomach
COSM1099534	c.436C>A	p.H146N	Substitution - Missense	Endometrium
COSM1456875	c.388G>T	p.G130C	Substitution - Missense	Large_intestine
COSM1099541	c.1666G>T	p.D556Y	Substitution - Missense	Endometrium
COSM3834646	c.1762G>A	p.D588N	Substitution - Missense	Breast
COSM2960100	c.1050G>A	p.P350P	Substitution - coding silent	Kidney
COSM1099533	c.415T>C	p.F139L	Substitution - Missense	Endometrium
COSM4649224	c.1091C>T	p.A364V	Substitution - Missense	Large_intestine
COSM3648808	c.1413C>T	p.S471S	Substitution - coding silent	Skin
COSM1456879	c.1461A>T	p.G487G	Substitution - coding silent	Large_intestine
COSM1283532	c.763G>T	p.G255*	Substitution - Nonsense	Autonomic_ganglia
COSM1099532	c.297G>A	p.A99A	Substitution - coding silent	Endometrium
COSM3731895	c.1621-6delT	p.?	Unknown	Stomach
COSM3899935	c.837T>C	p.T279T	Substitution - coding silent	Stomach
COSM454519	c.718C>A	p.P240T	Substitution - Missense	Breast
COSM3763333	c.13G>C	p.G5R	Substitution - Missense	Large_intestine
COSM5886570	c.1774C>T	p.R592C	Substitution - Missense	Skin
COSM2960091	c.262G>A	p.A88T	Substitution - Missense	Large_intestine
COSM4404199	c.1046A>C	p.D349A	Substitution - Missense	Skin
COSM454521	c.1849G>A	p.E617K	Substitution - Missense	Endometrium
COSM3899934	c.777+1G>C	p.?	Unknown	Stomach
COSM1099543	c.1754C>A	p.P585H	Substitution - Missense	Endometrium
COSM1187519	c.1772A>T	p.Y591F	Substitution - Missense	Lung
COSM5063180	c.1133A>G	p.Y378C	Substitution - Missense	Stomach
COSM4970270	c.1215G>T	p.K405N	Substitution - Missense	Central_nervous_system
COSM5476820	c.756C>A	p.P252P	Substitution - coding silent	Large_intestine
COSM1314026	c.796C>T	p.P266S	Substitution - Missense	Urinary_tract
COSM1623982	c.300C>A	p.G100G	Substitution - coding silent	Liver
COSM454521	c.1849G>A	p.E617K	Substitution - Missense	Breast
COSM1099538	c.1447G>A	p.G483R	Substitution - Missense	Endometrium
COSM2960103	c.1163G>A	p.R388Q	Substitution - Missense	Large_intestine
COSM1242013	c.1349C>A	p.P450H	Substitution - Missense	Oesophagus
COSM363004	c.1480G>A	p.E494K	Substitution - Missense	Lung
COSM3899933	c.479G>A	p.R160Q	Substitution - Missense	Stomach
COSM5965092	c.1012A>C	p.K338Q	Substitution - Missense	Breast
COSM1099530	c.212G>A	p.S71N	Substitution - Missense	Endometrium
COSM5507146	c.1043C>T	p.P348L	Substitution - Missense	Biliary_tract
COSM1456877	c.1286A>G	p.E429G	Substitution - Missense	Large_intestine
COSM1317224	c.171C>T	p.S57S	Substitution - coding silent	Biliary_tract
COSM4646827	c.925G>A	p.G309R	Substitution - Missense	Large_intestine
COSM5893279	c.1105C>T	p.P369S	Substitution - Missense	Skin
COSM4455399	c.757A>G	p.K253E	Substitution - Missense	Skin
COSM1099544	c.1757C>T	p.P586L	Substitution - Missense	Endometrium
COSM4663707	c.1247T>C	p.V416A	Substitution - Missense	Large_intestine
COSM2960114	c.1841T>C	p.V614A	Substitution - Missense	Large_intestine
COSM1099540	c.1593G>T	p.K531N	Substitution - Missense	Endometrium
COSM150486	c.1720-7G>A	p.?	Unknown	Stomach
COSM5884698	c.1348C>T	p.P450S	Substitution - Missense	Skin
COSM3648806	c.575C>T	p.S192F	Substitution - Missense	Skin
COSM750498	c.521C>T	p.A174V	Substitution - Missense	Lung
COSM5409538	c.1789A>C	p.M597L	Substitution - Missense	Skin
COSM3899931	c.322C>T	p.R108*	Substitution - Nonsense	Stomach
COSM1317224	c.171C>T	p.S57S	Substitution - coding silent	Thyroid
COSM2960091	c.262G>A	p.A88T	Substitution - Missense	Large_intestine
COSM1099537	c.1025G>A	p.R342Q	Substitution - Missense	Endometrium
COSM1456880	c.1758G>A	p.P586P	Substitution - coding silent	Large_intestine
COSM5893279	c.1105C>T	p.P369S	Substitution - Missense	Skin
COSM1456876	c.971G>A	p.R324H	Substitution - Missense	Large_intestine
COSM454518	c.447C>T	p.V149V	Substitution - coding silent	Breast
COSM5409537	c.1680G>A	p.G560G	Substitution - coding silent	Skin
COSM187128	c.1249C>T	p.R417W	Substitution - Missense	Endometrium
COSM3899932	c.384A>T	p.T128T	Substitution - coding silent	Stomach
COSM2960114	c.1841T>C	p.V614A	Substitution - Missense	Large_intestine
COSM1183764	c.377C>T	p.A126V	Substitution - Missense	Large_intestine
COSM338875	c.682-1G>T	p.?	Unknown	Lung
COSM1643595	c.1565_1566insA	p.D524fs*5	Insertion - Frameshift	Stomach
COSM454520	c.1749G>T	p.K583N	Substitution - Missense	Breast
COSM3996044	c.163C>T	p.P55S	Substitution - Missense	Kidney
COSM5998104	c.916G>T	p.G306W	Substitution - Missense	Prostate
COSM4663708	c.1601A>C	p.K534T	Substitution - Missense	Large_intestine
COSM4795580	c.1585G>A	p.A529T	Substitution - Missense	Liver
COSM486419	c.778G>T	p.D260Y	Substitution - Missense	Kidney
COSM1673858	c.1219T>C	p.Y407H	Substitution - Missense	Ovary
COSM1292686	c.110C>T	p.A37V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4424940	c.1053C>T	p.H351H	Substitution - coding silent	Oesophagus
COSM4833968	c.1152C>G	p.A384A	Substitution - coding silent	Cervix
COSM1569061	c.1192C>T	p.R398W	Substitution - Missense	Large_intestine
COSM3648804	c.401C>T	p.S134L	Substitution - Missense	Skin
COSM1099539	c.1453G>A	p.V485I	Substitution - Missense	Endometrium
COSM1317224	c.171C>T	p.S57S	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue

> Text Mining based Variations [ TOP ]
There is no record for ASH2L.

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UBL3	296	R	Asymmetric dimethylarginine	PRMT1 and PRMT5	No	None detected
Q9UBL3	316	S	Phosphoserine	-	No	None detected

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.699	5.551	-0.166	0.391	NS
BRCA	Breast invasive carcinoma	112	1100	5.883	5.99	0.209	0.0187	NS
CESC	Cervical and endocervical cancers	3	306	5.878	5.737	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.665	5.489	-0.215	0.0156	NS
ESCA	Esophageal carcinoma	11	185	5.684	5.444	-0.135	0.618	NS
GBM	Glioblastoma multiforme	5	166	6.149	5.788	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.492	5.458	-0.042	0.719	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.716	5.647	-0.148	0.00153	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.629	5.502	-0.163	0.0514	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.376	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.743	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.773	4.306	-0.424	1.19e-05	NS
LUAD	Lung adenocarcinoma	59	517	5.616	5.428	-0.142	0.0798	NS
LUSC	Lung squamous cell carcinoma	51	501	5.583	5.815	0.4	0.00153	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.519	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.512	5.455	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.317	5.403	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.721	5.531	-0.259	4.08e-05	NS
READ	Rectum adenocarcinoma	10	167	5.715	5.369	-0.346	0.0938	NS
SARC	Sarcoma	2	263	5.907	5.904	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.174	6.067	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.68	5.523	-0.212	0.0346	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.519	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.43	5.513	0.045	0.218	NS
THYM	Thymoma	2	120	6.079	6.246	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.762	5.43	-0.34	0.000582	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.2
Autonomic ganglia	CHP212	9.8
Autonomic ganglia	IMR32	10.3
Autonomic ganglia	KELLY	10.1
Autonomic ganglia	KPNRTBM1	10.5
Autonomic ganglia	KPNSI9S	10
Autonomic ganglia	KPNYN	10.6
Autonomic ganglia	MHHNB11	10.3
Autonomic ganglia	NB1	9.9
Autonomic ganglia	NH6	10.6
Autonomic ganglia	SHSY5Y	10
Autonomic ganglia	SIMA	10
Autonomic ganglia	SKNAS	10.1
Autonomic ganglia	SKNBE2	10.9
Autonomic ganglia	SKNDZ	10.6
Autonomic ganglia	SKNFI	10.4
Autonomic ganglia	SKNSH	10.1
Biliary tract	HUCCT1	10.3
Biliary tract	HUH28	9.4
Biliary tract	SNU1079	9.3
Biliary tract	SNU1196	10.6
Biliary tract	SNU245	10.1
Biliary tract	SNU308	10.1
Biliary tract	SNU478	9.1
Bone	143B	10.1
Bone	A673	11.2
Bone	CADOES1	10.5
Bone	CAL78	10.2
Bone	G292CLONEA141B1	11.7
Bone	HOS	9.9
Bone	HS706T	10.6
Bone	HS737T	10.1
Bone	HS819T	9.9
Bone	HS821T	10
Bone	HS822T	9.9
Bone	HS863T	10
Bone	HS870T	10.2
Bone	HS888T	9.8
Bone	MG63	10.1
Bone	MHHES1	11.1
Bone	OUMS27	10.4
Bone	RDES	11.4
Bone	SJSA1	10.7
Bone	SKES1	11
Bone	SKNMC	11.9
Bone	SW1353	10.2
Bone	T173	10.5
Bone	TC71	10.9
Bone	U2OS	10.9
Breast	AU565	9.2
Breast	BT20	10.4
Breast	BT474	10.1
Breast	BT483	13.3
Breast	BT549	11
Breast	CAL120	11.7
Breast	CAL148	10.2
Breast	CAL51	10.1
Breast	CAL851	9.9
Breast	CAMA1	11.8
Breast	DU4475	10.6
Breast	EFM192A	10
Breast	EFM19	8.8
Breast	EVSAT	10.7
Breast	HCC1143	9.9
Breast	HCC1187	10.5
Breast	HCC1395	10.2
Breast	HCC1419	9.9
Breast	HCC1428	10.4
Breast	HCC1500	10.2
Breast	HCC1569	11.1
Breast	HCC1599	9.8
Breast	HCC1806	9.9
Breast	HCC1937	9.6
Breast	HCC1954	9.5
Breast	HCC202	10.2
Breast	HCC2157	9.2
Breast	HCC2218	9.4
Breast	HCC38	11.1
Breast	HCC70	8.8
Breast	HDQP1	9.4
Breast	HMC18	10
Breast	HS274T	10.1
Breast	HS281T	10
Breast	HS343T	10.1
Breast	HS578T	10.4
Breast	HS606T	9.9
Breast	HS739T	10.1
Breast	HS742T	9.7
Breast	JIMT1	12.4
Breast	KPL1	9.8
Breast	MCF7	9.7
Breast	MDAMB134VI	12.7
Breast	MDAMB157	10.8
Breast	MDAMB175VII	9.7
Breast	MDAMB231	10
Breast	MDAMB361	10.5
Breast	MDAMB415	9.3
Breast	MDAMB436	9.2
Breast	MDAMB453	10.7
Breast	MDAMB468	9.8
Breast	SKBR3	9.5
Breast	T47D	10
Breast	UACC812	9.8
Breast	UACC893	9.7
Breast	YMB1	11.3
Breast	ZR751	10.9
Breast	ZR7530	9.1
Central nervous system	1321N1	9.9
Central nervous system	42MGBA	9.9
Central nervous system	8MGBA	9.6
Central nervous system	A172	10.7
Central nervous system	AM38	10.1
Central nervous system	BECKER	10.1
Central nervous system	CAS1	10.2
Central nervous system	CCFSTTG1	10.7
Central nervous system	D283MED	10.6
Central nervous system	D341MED	10.5
Central nervous system	DAOY	9.8
Central nervous system	DBTRG05MG	9.6
Central nervous system	DKMG	9.6
Central nervous system	GAMG	10.1
Central nervous system	GB1	9.4
Central nervous system	GI1	11
Central nervous system	GMS10	10.9
Central nervous system	GOS3	10.2
Central nervous system	H4	9.9
Central nervous system	HS683	10.4
Central nervous system	KALS1	10.3
Central nervous system	KG1C	10.3
Central nervous system	KNS42	9.5
Central nervous system	KNS60	9.3
Central nervous system	KNS81	9.9
Central nervous system	KS1	10
Central nervous system	LN18	10
Central nervous system	LN229	10.4
Central nervous system	M059K	9.9
Central nervous system	MOGGCCM	9.9
Central nervous system	MOGGUVW	9.9
Central nervous system	NMCG1	10.2
Central nervous system	ONS76	10.1
Central nervous system	SF126	10.4
Central nervous system	SF295	10
Central nervous system	SNB19	9.8
Central nervous system	SNU1105	10.2
Central nervous system	SNU201	10.5
Central nervous system	SNU466	10.5
Central nervous system	SNU489	9.9
Central nervous system	SNU626	9.9
Central nervous system	SNU738	9.6
Central nervous system	SW1088	10.1
Central nervous system	SW1783	10.5
Central nervous system	T98G	10
Central nervous system	TM31	10.2
Central nervous system	U118MG	9.7
Central nervous system	U138MG	10.5
Central nervous system	U251MG	9.6
Central nervous system	U87MG	10.1
Central nervous system	YH13	10.3
Central nervous system	YKG1	10.1
Endometrium	AN3CA	10.5
Endometrium	COLO684	10.8
Endometrium	EFE184	9.4
Endometrium	EN	10.2
Endometrium	ESS1	10.2
Endometrium	HEC108	10.2
Endometrium	HEC151	9.8
Endometrium	HEC1A	9.9
Endometrium	HEC1B	10
Endometrium	HEC251	9.8
Endometrium	HEC265	9.7
Endometrium	HEC50B	9.9
Endometrium	HEC59	10.3
Endometrium	HEC6	9.8
Endometrium	ISHIKAWAHERAKLIO02ER	10.1
Endometrium	JHUEM1	10.3
Endometrium	JHUEM2	10.1
Endometrium	JHUEM3	9.3
Endometrium	KLE	9.7
Endometrium	MFE280	10.4
Endometrium	MFE296	10.7
Endometrium	MFE319	9.7
Endometrium	RL952	10.9
Endometrium	SNGM	9.4
Endometrium	SNU1077	9.9
Endometrium	SNU685	9.5
Endometrium	TEN	9.9
Haematopoietic and lymphoid	697	10.5
Haematopoietic and lymphoid	A3KAW	9.9
Haematopoietic and lymphoid	A4FUK	9.9
Haematopoietic and lymphoid	ALLSIL	11.2
Haematopoietic and lymphoid	AML193	10.9
Haematopoietic and lymphoid	AMO1	10.3
Haematopoietic and lymphoid	BCP1	10.3
Haematopoietic and lymphoid	BDCM	10.2
Haematopoietic and lymphoid	BL41	10.6
Haematopoietic and lymphoid	BL70	10.7
Haematopoietic and lymphoid	BV173	11.9
Haematopoietic and lymphoid	CA46	10.9
Haematopoietic and lymphoid	CI1	10.4
Haematopoietic and lymphoid	CMK115	11.2
Haematopoietic and lymphoid	CMK86	11.1
Haematopoietic and lymphoid	CMK	11.2
Haematopoietic and lymphoid	CMLT1	10
Haematopoietic and lymphoid	COLO775	9.2
Haematopoietic and lymphoid	DAUDI	10.6
Haematopoietic and lymphoid	DB	10.6
Haematopoietic and lymphoid	DEL	9.9
Haematopoietic and lymphoid	DND41	10.9
Haematopoietic and lymphoid	DOHH2	10.7
Haematopoietic and lymphoid	EB1	10.4
Haematopoietic and lymphoid	EB2	10
Haematopoietic and lymphoid	EHEB	10
Haematopoietic and lymphoid	EJM	9.5
Haematopoietic and lymphoid	EM2	10.7
Haematopoietic and lymphoid	EOL1	11.1
Haematopoietic and lymphoid	F36P	11.9
Haematopoietic and lymphoid	GA10	10.8
Haematopoietic and lymphoid	GDM1	11.9
Haematopoietic and lymphoid	GRANTA519	10
Haematopoietic and lymphoid	HDLM2	9.6
Haematopoietic and lymphoid	HDMYZ	10.2
Haematopoietic and lymphoid	HEL9217	12
Haematopoietic and lymphoid	HEL	12.2
Haematopoietic and lymphoid	HH	11
Haematopoietic and lymphoid	HL60	10.8
Haematopoietic and lymphoid	HPBALL	10.7
Haematopoietic and lymphoid	HS604T	10
Haematopoietic and lymphoid	HS611T	10.9
Haematopoietic and lymphoid	HS616T	10.1
Haematopoietic and lymphoid	HS751T	10.2
Haematopoietic and lymphoid	HT	10.3
Haematopoietic and lymphoid	HTK	9.9
Haematopoietic and lymphoid	HUNS1	10.6
Haematopoietic and lymphoid	HUT102	10
Haematopoietic and lymphoid	HUT78	10.7
Haematopoietic and lymphoid	JEKO1	10.6
Haematopoietic and lymphoid	JK1	12.4
Haematopoietic and lymphoid	JM1	10.9
Haematopoietic and lymphoid	JURKAT	10.9
Haematopoietic and lymphoid	JURLMK1	11.6
Haematopoietic and lymphoid	JVM2	9.5
Haematopoietic and lymphoid	JVM3	9.8
Haematopoietic and lymphoid	K562	12.2
Haematopoietic and lymphoid	KARPAS299	10.2
Haematopoietic and lymphoid	KARPAS422	10.1
Haematopoietic and lymphoid	KARPAS620	10.6
Haematopoietic and lymphoid	KASUMI1	10.4
Haematopoietic and lymphoid	KASUMI2	10.6
Haematopoietic and lymphoid	KASUMI6	10.5
Haematopoietic and lymphoid	KCL22	11.7
Haematopoietic and lymphoid	KE37	10.2
Haematopoietic and lymphoid	KE97	10.7
Haematopoietic and lymphoid	KG1	11.8
Haematopoietic and lymphoid	KHM1B	10.4
Haematopoietic and lymphoid	KIJK	10.2
Haematopoietic and lymphoid	KMH2	9.2
Haematopoietic and lymphoid	KMM1	10.4
Haematopoietic and lymphoid	KMS11	10.1
Haematopoietic and lymphoid	KMS12BM	10.4
Haematopoietic and lymphoid	KMS18	10.7
Haematopoietic and lymphoid	KMS20	10.1
Haematopoietic and lymphoid	KMS21BM	10
Haematopoietic and lymphoid	KMS26	9.7
Haematopoietic and lymphoid	KMS27	10.4
Haematopoietic and lymphoid	KMS28BM	9.5
Haematopoietic and lymphoid	KMS34	9.5
Haematopoietic and lymphoid	KO52	11.4
Haematopoietic and lymphoid	KOPN8	10.9
Haematopoietic and lymphoid	KU812	11.7
Haematopoietic and lymphoid	KYO1	12.5
Haematopoietic and lymphoid	L1236	9.7
Haematopoietic and lymphoid	L363	9.7
Haematopoietic and lymphoid	L428	10.2
Haematopoietic and lymphoid	L540	9.9
Haematopoietic and lymphoid	LAMA84	11.9
Haematopoietic and lymphoid	LOUCY	10.9
Haematopoietic and lymphoid	LP1	10.3
Haematopoietic and lymphoid	M07E	11.5
Haematopoietic and lymphoid	MC116	10
Haematopoietic and lymphoid	ME1	11.7
Haematopoietic and lymphoid	MEC1	10.1
Haematopoietic and lymphoid	MEC2	10.2
Haematopoietic and lymphoid	MEG01	11.5
Haematopoietic and lymphoid	MHHCALL2	10.4
Haematopoietic and lymphoid	MHHCALL3	11
Haematopoietic and lymphoid	MHHCALL4	10.7
Haematopoietic and lymphoid	MINO	10.1
Haematopoietic and lymphoid	MJ	10.5
Haematopoietic and lymphoid	MM1S	10.1
Haematopoietic and lymphoid	MOLM13	11.7
Haematopoietic and lymphoid	MOLM16	11.3
Haematopoietic and lymphoid	MOLM6	11.4
Haematopoietic and lymphoid	MOLP2	9.2
Haematopoietic and lymphoid	MOLP8	10.1
Haematopoietic and lymphoid	MOLT13	10.7
Haematopoietic and lymphoid	MOLT16	10.4
Haematopoietic and lymphoid	MOLT4	11.1
Haematopoietic and lymphoid	MONOMAC1	11.3
Haematopoietic and lymphoid	MONOMAC6	11.1
Haematopoietic and lymphoid	MOTN1	10.4
Haematopoietic and lymphoid	MUTZ5	10.5
Haematopoietic and lymphoid	MV411	11.3
Haematopoietic and lymphoid	NALM19	10.9
Haematopoietic and lymphoid	NALM1	10.6
Haematopoietic and lymphoid	NALM6	10.6
Haematopoietic and lymphoid	NAMALWA	9.8
Haematopoietic and lymphoid	NB4	10.3
Haematopoietic and lymphoid	NCIH929	10.3
Haematopoietic and lymphoid	NCO2	12.6
Haematopoietic and lymphoid	NOMO1	11.5
Haematopoietic and lymphoid	NUDHL1	10.5
Haematopoietic and lymphoid	NUDUL1	10.3
Haematopoietic and lymphoid	OCIAML2	11.7
Haematopoietic and lymphoid	OCIAML3	11.4
Haematopoietic and lymphoid	OCIAML5	11.7
Haematopoietic and lymphoid	OCILY10	10.3
Haematopoietic and lymphoid	OCILY19	11.3
Haematopoietic and lymphoid	OCILY3	10.4
Haematopoietic and lymphoid	OCIM1	12.7
Haematopoietic and lymphoid	OPM2	10.5
Haematopoietic and lymphoid	P12ICHIKAWA	10.7
Haematopoietic and lymphoid	P31FUJ	10.9
Haematopoietic and lymphoid	P3HR1	10.7
Haematopoietic and lymphoid	PCM6	10.7
Haematopoietic and lymphoid	PEER	10.7
Haematopoietic and lymphoid	PF382	10.8
Haematopoietic and lymphoid	PFEIFFER	9.1
Haematopoietic and lymphoid	PL21	11.3
Haematopoietic and lymphoid	RAJI	10.1
Haematopoietic and lymphoid	RCHACV	11.2
Haematopoietic and lymphoid	REC1	9.6
Haematopoietic and lymphoid	REH	10.5
Haematopoietic and lymphoid	RI1	10.6
Haematopoietic and lymphoid	RL	10.6
Haematopoietic and lymphoid	RPMI8226	9.4
Haematopoietic and lymphoid	RPMI8402	12.2
Haematopoietic and lymphoid	RS411	10.3
Haematopoietic and lymphoid	SEM	11.2
Haematopoietic and lymphoid	SET2	11.5
Haematopoietic and lymphoid	SIGM5	11
Haematopoietic and lymphoid	SKM1	10.8
Haematopoietic and lymphoid	SKMM2	9
Haematopoietic and lymphoid	SR786	10.9
Haematopoietic and lymphoid	ST486	10.5
Haematopoietic and lymphoid	SUDHL10	10.9
Haematopoietic and lymphoid	SUDHL1	10
Haematopoietic and lymphoid	SUDHL4	11
Haematopoietic and lymphoid	SUDHL5	10.4
Haematopoietic and lymphoid	SUDHL6	11.1
Haematopoietic and lymphoid	SUDHL8	10.6
Haematopoietic and lymphoid	SUPB15	10.9
Haematopoietic and lymphoid	SUPHD1	10.6
Haematopoietic and lymphoid	SUPM2	9.7
Haematopoietic and lymphoid	SUPT11	10.7
Haematopoietic and lymphoid	SUPT1	10.8
Haematopoietic and lymphoid	TALL1	10.7
Haematopoietic and lymphoid	TF1	11.2
Haematopoietic and lymphoid	THP1	11.6
Haematopoietic and lymphoid	TO175T	10.3
Haematopoietic and lymphoid	TOLEDO	10.6
Haematopoietic and lymphoid	U266B1	10.5
Haematopoietic and lymphoid	U937	10.9
Haematopoietic and lymphoid	UT7	11.3
Haematopoietic and lymphoid	WSUDLCL2	11.5
Kidney	769P	10
Kidney	786O	9.5
Kidney	A498	9.9
Kidney	A704	8.7
Kidney	ACHN	9.6
Kidney	BFTC909	9.2
Kidney	CAKI1	10
Kidney	CAKI2	9.8
Kidney	CAL54	9.7
Kidney	KMRC1	10
Kidney	KMRC20	10.1
Kidney	KMRC2	9.9
Kidney	KMRC3	10
Kidney	OSRC2	9
Kidney	RCC10RGB	10
Kidney	SNU1272	9.7
Kidney	SNU349	9.3
Kidney	TUHR10TKB	9.4
Kidney	TUHR14TKB	9.8
Kidney	TUHR4TKB	9.4
Kidney	VMRCRCW	9.2
Kidney	VMRCRCZ	9.9
Large intestine	C2BBE1	10
Large intestine	CCK81	10.1
Large intestine	CL11	9.6
Large intestine	CL14	9.4
Large intestine	CL34	9.9
Large intestine	CL40	9.8
Large intestine	COLO205	9.6
Large intestine	COLO320	10
Large intestine	COLO678	9.8
Large intestine	CW2	10.5
Large intestine	DLD1	10
Large intestine	GP2D	10
Large intestine	HCC56	8.9
Large intestine	HCT116	10.3
Large intestine	HCT15	10.1
Large intestine	HS675T	9.9
Large intestine	HS698T	9.9
Large intestine	HT115	10
Large intestine	HT29	8.3
Large intestine	HT55	9.7
Large intestine	KM12	9.6
Large intestine	LOVO	9.7
Large intestine	LS1034	9.9
Large intestine	LS123	10
Large intestine	LS180	10
Large intestine	LS411N	10.2
Large intestine	LS513	9.7
Large intestine	MDST8	10.6
Large intestine	NCIH508	9.4
Large intestine	NCIH716	9.9
Large intestine	NCIH747	9.9
Large intestine	OUMS23	9.5
Large intestine	RCM1	9.1
Large intestine	RKO	9.5
Large intestine	SKCO1	9.7
Large intestine	SNU1040	9.8
Large intestine	SNU1197	9.9
Large intestine	SNU175	9.4
Large intestine	SNU283	10.1
Large intestine	SNU407	10
Large intestine	SNU503	10.7
Large intestine	SNU61	9.1
Large intestine	SNU81	9.8
Large intestine	SNUC1	11
Large intestine	SNUC2A	10.3
Large intestine	SNUC4	10.1
Large intestine	SNUC5	9.8
Large intestine	SW1116	10.2
Large intestine	SW1417	8.6
Large intestine	SW1463	9.2
Large intestine	SW403	10.1
Large intestine	SW480	9.5
Large intestine	SW48	9.7
Large intestine	SW620	9.9
Large intestine	SW837	10.8
Large intestine	SW948	9.6
Large intestine	T84	8.9
Liver	ALEXANDERCELLS	9.5
Liver	C3A	10.3
Liver	HEP3B217	9.9
Liver	HEPG2	10.6
Liver	HLE	9.8
Liver	HLF	9.5
Liver	HUH1	9.1
Liver	HUH6	9.4
Liver	HUH7	11.1
Liver	JHH1	10.3
Liver	JHH2	9.7
Liver	JHH4	9.5
Liver	JHH5	9.8
Liver	JHH6	9.3
Liver	JHH7	9.4
Liver	LI7	10
Liver	PLCPRF5	9.8
Liver	SKHEP1	9.6
Liver	SNU182	9.6
Liver	SNU387	9.5
Liver	SNU398	9.6
Liver	SNU423	9.1
Liver	SNU449	9.9
Liver	SNU475	9.7
Liver	SNU761	9.2
Liver	SNU878	9
Liver	SNU886	9.3
Lung	A549	9.6
Lung	ABC1	9.3
Lung	BEN	9.1
Lung	CAL12T	10.4
Lung	CALU1	9.7
Lung	CALU3	10.5
Lung	CALU6	9.7
Lung	CHAGOK1	8.9
Lung	COLO668	10.5
Lung	COLO699	10.9
Lung	CORL105	9
Lung	CORL23	10.1
Lung	CORL24	10.6
Lung	CORL279	10.2
Lung	CORL311	10.1
Lung	CORL47	10.7
Lung	CORL51	10.4
Lung	CORL88	12
Lung	CORL95	10.7
Lung	CPCN	10.6
Lung	DMS114	12.6
Lung	DMS153	9.7
Lung	DMS273	9.5
Lung	DMS454	10.8
Lung	DMS53	10.6
Lung	DMS79	10.8
Lung	DV90	9.9
Lung	EBC1	9.8
Lung	EPLC272H	10.3
Lung	HARA	11
Lung	HCC1171	10
Lung	HCC1195	9.5
Lung	HCC15	9.8
Lung	HCC2279	8.8
Lung	HCC2935	9
Lung	HCC33	9.5
Lung	HCC366	9.6
Lung	HCC4006	9.4
Lung	HCC44	9.1
Lung	HCC78	9.9
Lung	HCC827	9.1
Lung	HCC95	11.2
Lung	HLC1	10
Lung	HLFA	9.5
Lung	HS229T	10.2
Lung	HS618T	10.1
Lung	IALM	10.4
Lung	KNS62	9.8
Lung	LC1F	9.8
Lung	LC1SQSF	9.4
Lung	LCLC103H	9.4
Lung	LCLC97TM1	9.7
Lung	LK2	11
Lung	LOUNH91	10
Lung	LU65	9.8
Lung	LU99	10.8
Lung	LUDLU1	9.5
Lung	LXF289	9.6
Lung	MORCPR	9.8
Lung	NCIH1048	10.7
Lung	NCIH1092	10.5
Lung	NCIH1105	10.5
Lung	NCIH1155	10.8
Lung	NCIH1184	10.2
Lung	NCIH1299	9.7
Lung	NCIH1339	9
Lung	NCIH1341	10.9
Lung	NCIH1355	10.2
Lung	NCIH1373	9.5
Lung	NCIH1385	10.9
Lung	NCIH1395	9.3
Lung	NCIH1435	9
Lung	NCIH1436	10.2
Lung	NCIH1437	10.4
Lung	NCIH146	10.5
Lung	NCIH1563	8.8
Lung	NCIH1568	10.3
Lung	NCIH1573	9.5
Lung	NCIH1581	11.4
Lung	NCIH1618	11
Lung	NCIH1623	9.6
Lung	NCIH1648	10.9
Lung	NCIH1650	9.1
Lung	NCIH1651	10.3
Lung	NCIH1666	9.3
Lung	NCIH1693	10.3
Lung	NCIH1694	10.2
Lung	NCIH1703	11.4
Lung	NCIH1734	11.1
Lung	NCIH1755	9.7
Lung	NCIH1781	9
Lung	NCIH1792	9.7
Lung	NCIH1793	9.9
Lung	NCIH1836	10.8
Lung	NCIH1838	10.4
Lung	NCIH1869	9.2
Lung	NCIH1876	10.5
Lung	NCIH1915	9
Lung	NCIH1930	10.6
Lung	NCIH1944	9.5
Lung	NCIH1963	10.6
Lung	NCIH196	10.8
Lung	NCIH1975	9.6
Lung	NCIH2009	8.8
Lung	NCIH2023	9.6
Lung	NCIH2029	9.9
Lung	NCIH2030	9.6
Lung	NCIH2066	10.5
Lung	NCIH2081	10.2
Lung	NCIH2085	10.5
Lung	NCIH2087	10.9
Lung	NCIH209	10.8
Lung	NCIH2106	10.7
Lung	NCIH2110	9.8
Lung	NCIH211	10.2
Lung	NCIH2122	10.1
Lung	NCIH2126	9.4
Lung	NCIH2141	10.4
Lung	NCIH2170	9.9
Lung	NCIH2171	9.6
Lung	NCIH2172	9.5
Lung	NCIH2196	10.2
Lung	NCIH2227	10.1
Lung	NCIH2228	10.5
Lung	NCIH226	10.9
Lung	NCIH2286	9.2
Lung	NCIH2291	9.2
Lung	NCIH2342	9.8
Lung	NCIH2347	10.2
Lung	NCIH23	9.8
Lung	NCIH2405	9.8
Lung	NCIH2444	11.1
Lung	NCIH292	9.3
Lung	NCIH322	9.6
Lung	NCIH3255	9.7
Lung	NCIH358	10.7
Lung	NCIH441	9.2
Lung	NCIH446	10.8
Lung	NCIH460	9.4
Lung	NCIH510	9.6
Lung	NCIH520	11.3
Lung	NCIH522	10.3
Lung	NCIH524	9.4
Lung	NCIH526	9.9
Lung	NCIH596	9.6
Lung	NCIH647	10
Lung	NCIH650	9.4
Lung	NCIH661	10.5
Lung	NCIH69	10.7
Lung	NCIH727	9.5
Lung	NCIH810	8.7
Lung	NCIH82	10.1
Lung	NCIH838	9.4
Lung	NCIH841	10.2
Lung	NCIH854	9.9
Lung	NCIH889	10.7
Lung	PC14	9.3
Lung	RERFLCAD1	10.4
Lung	RERFLCAD2	10.1
Lung	RERFLCAI	10.2
Lung	RERFLCKJ	9.8
Lung	RERFLCMS	10
Lung	RERFLCSQ1	9.4
Lung	SBC5	10.9
Lung	SCLC21H	9.2
Lung	SHP77	10.6
Lung	SKLU1	10.3
Lung	SKMES1	9.6
Lung	SQ1	8.4
Lung	SW1271	9.2
Lung	SW1573	9.7
Lung	SW900	10
Lung	VMRCLCD	9.5
Lung	VMRCLCP	10.2
Oesophagus	COLO680N	8.8
Oesophagus	ECGI10	9.4
Oesophagus	KYSE140	10.5
Oesophagus	KYSE150	9.4
Oesophagus	KYSE180	9.1
Oesophagus	KYSE270	9.8
Oesophagus	KYSE30	9.3
Oesophagus	KYSE410	10
Oesophagus	KYSE450	9.7
Oesophagus	KYSE510	10
Oesophagus	KYSE520	9.5
Oesophagus	KYSE70	10
Oesophagus	OE19	10
Oesophagus	OE33	9.2
Oesophagus	TE10	9.8
Oesophagus	TE11	10
Oesophagus	TE14	10.5
Oesophagus	TE15	9.7
Oesophagus	TE1	10.1
Oesophagus	TE4	9.2
Oesophagus	TE5	9.2
Oesophagus	TE6	10.1
Oesophagus	TE8	9.6
Oesophagus	TE9	9.9
Oesophagus	TT	10
Ovary	59M	9.9
Ovary	A2780	10.3
Ovary	CAOV3	9.4
Ovary	CAOV4	9.8
Ovary	COLO704	10.2
Ovary	COV318	9.8
Ovary	COV362	9.3
Ovary	COV434	9.7
Ovary	COV504	9.9
Ovary	COV644	10
Ovary	EFO21	10.1
Ovary	EFO27	10.1
Ovary	ES2	9.9
Ovary	FUOV1	9.3
Ovary	HEYA8	10.2
Ovary	HS571T	10.1
Ovary	IGROV1	10
Ovary	JHOC5	10.6
Ovary	JHOM1	9.8
Ovary	JHOM2B	9
Ovary	JHOS2	9.3
Ovary	JHOS4	10.5
Ovary	KURAMOCHI	9.4
Ovary	MCAS	10.6
Ovary	NIHOVCAR3	9.8
Ovary	OAW28	9.6
Ovary	OAW42	10.3
Ovary	OC314	10
Ovary	OC316	10
Ovary	ONCODG1	9.4
Ovary	OV56	9.3
Ovary	OV7	9.6
Ovary	OV90	9.6
Ovary	OVCAR4	9.3
Ovary	OVCAR8	10.5
Ovary	OVISE	9.1
Ovary	OVK18	10.9
Ovary	OVKATE	9.6
Ovary	OVMANA	8.3
Ovary	OVSAHO	9.4
Ovary	OVTOKO	10.1
Ovary	RMGI	10
Ovary	RMUGS	9.8
Ovary	SKOV3	10.3
Ovary	SNU119	9.5
Ovary	SNU840	9.4
Ovary	SNU8	9.6
Ovary	TOV112D	10.5
Ovary	TOV21G	9.9
Ovary	TYKNU	10.2
Pancreas	ASPC1	10.1
Pancreas	BXPC3	10.5
Pancreas	CAPAN1	10.5
Pancreas	CAPAN2	9.6
Pancreas	CFPAC1	9.6
Pancreas	DANG	12.2
Pancreas	HPAC	9.9
Pancreas	HPAFII	9.9
Pancreas	HS766T	10.1
Pancreas	HUPT3	9.1
Pancreas	HUPT4	9.5
Pancreas	KCIMOH1	10.5
Pancreas	KLM1	9.9
Pancreas	KP2	9.9
Pancreas	KP3	9.7
Pancreas	KP4	9.5
Pancreas	L33	10.1
Pancreas	MIAPACA2	9.6
Pancreas	PANC0203	9.1
Pancreas	PANC0213	9.9
Pancreas	PANC0327	10
Pancreas	PANC0403	10.4
Pancreas	PANC0504	10.3
Pancreas	PANC0813	10.1
Pancreas	PANC1005	9.1
Pancreas	PANC1	9.6
Pancreas	PATU8902	10.7
Pancreas	PATU8988S	10.7
Pancreas	PATU8988T	10.9
Pancreas	PK1	9.6
Pancreas	PK45H	9.9
Pancreas	PK59	10
Pancreas	PL45	9.2
Pancreas	PSN1	9.3
Pancreas	QGP1	9.4
Pancreas	SNU213	10.8
Pancreas	SNU324	9.9
Pancreas	SNU410	9.6
Pancreas	SU8686	9.1
Pancreas	SUIT2	9.5
Pancreas	SW1990	10.1
Pancreas	T3M4	10.1
Pancreas	TCCPAN2	10.3
Pancreas	YAPC	9.5
Pleura	ACCMESO1	10
Pleura	DM3	9.8
Pleura	ISTMES1	10.6
Pleura	ISTMES2	10.8
Pleura	JL1	10.8
Pleura	MPP89	10.9
Pleura	MSTO211H	10.3
Pleura	NCIH2052	9.9
Pleura	NCIH2452	11
Pleura	NCIH28	9.6
Prostate	22RV1	10.3
Prostate	DU145	10.3
Prostate	LNCAPCLONEFGC	10.2
Prostate	MDAPCA2B	9.7
Prostate	NCIH660	10
Prostate	PC3	9.4
Prostate	VCAP	9.8
Salivary gland	A253	9.3
Salivary gland	YD15	9.6
Skin	A101D	10.2
Skin	A2058	10.5
Skin	A375	10.5
Skin	C32	10.6
Skin	CHL1	10.8
Skin	CJM	10
Skin	COLO679	11.2
Skin	COLO741	10.6
Skin	COLO783	11.2
Skin	COLO792	10.4
Skin	COLO800	10.5
Skin	COLO818	10.9
Skin	COLO829	11.4
Skin	COLO849	11
Skin	G361	9.8
Skin	GRM	10
Skin	HMCB	11.1
Skin	HS294T	10.2
Skin	HS600T	10.1
Skin	HS688AT	10.1
Skin	HS695T	10.7
Skin	HS839T	10.3
Skin	HS852T	10.2
Skin	HS895T	9.9
Skin	HS934T	10.2
Skin	HS936T	9.9
Skin	HS939T	10.5
Skin	HS940T	10.3
Skin	HS944T	10.3
Skin	HT144	10.2
Skin	IGR1	10.2
Skin	IGR37	10.6
Skin	IGR39	10.2
Skin	IPC298	10.8
Skin	K029AX	10.9
Skin	LOXIMVI	10
Skin	MALME3M	10.7
Skin	MDAMB435S	10.3
Skin	MELHO	10.7
Skin	MELJUSO	10.7
Skin	MEWO	10.2
Skin	RPMI7951	10.1
Skin	RVH421	11.1
Skin	SH4	10.2
Skin	SKMEL1	10.4
Skin	SKMEL24	10.9
Skin	SKMEL28	10.7
Skin	SKMEL2	10.6
Skin	SKMEL30	10.6
Skin	SKMEL31	10.7
Skin	SKMEL3	10.6
Skin	SKMEL5	10.5
Skin	UACC257	9.6
Skin	UACC62	11
Skin	WM115	10.4
Skin	WM1799	11.3
Skin	WM2664	10.6
Skin	WM793	10.4
Skin	WM88	10.4
Skin	WM983B	10.3
Small intestine	HUTU80	10.1
Soft tissue	A204	10.6
Soft tissue	G401	10.2
Soft tissue	G402	10
Soft tissue	GCT	9.7
Soft tissue	HS729	10.8
Soft tissue	HT1080	10
Soft tissue	KYM1	11.6
Soft tissue	MESSA	10.4
Soft tissue	RD	10.1
Soft tissue	RH30	9.5
Soft tissue	RH41	10.5
Soft tissue	RKN	9.9
Soft tissue	S117	9.5
Soft tissue	SJRH30	9.6
Soft tissue	SKLMS1	10.2
Soft tissue	SKUT1	10.3
Soft tissue	TE125T	10
Soft tissue	TE159T	10.1
Soft tissue	TE441T	10.8
Soft tissue	TE617T	10.2
Stomach	2313287	10
Stomach	AGS	10
Stomach	AZ521	10
Stomach	ECC10	10.6
Stomach	ECC12	9.9
Stomach	FU97	10.9
Stomach	GCIY	10
Stomach	GSS	9.6
Stomach	GSU	10.2
Stomach	HGC27	10.8
Stomach	HS746T	10.1
Stomach	HUG1N	10.3
Stomach	IM95	10.2
Stomach	KATOIII	9.7
Stomach	KE39	9.9
Stomach	LMSU	11.9
Stomach	MKN1	9.4
Stomach	MKN45	8.6
Stomach	MKN74	10
Stomach	MKN7	10.2
Stomach	NCCSTCK140	10.4
Stomach	NCIN87	9
Stomach	NUGC2	10.2
Stomach	NUGC3	10.3
Stomach	NUGC4	9.1
Stomach	OCUM1	10.4
Stomach	RERFGC1B	9.7
Stomach	SH10TC	10.1
Stomach	SNU16	10.1
Stomach	SNU1	10.1
Stomach	SNU216	8.8
Stomach	SNU520	10
Stomach	SNU5	10.4
Stomach	SNU601	9.2
Stomach	SNU620	10.7
Stomach	SNU668	9
Stomach	SNU719	9.7
Stomach	TGBC11TKB	9.9
Thyroid	8305C	9.7
Thyroid	8505C	9.2
Thyroid	BCPAP	10
Thyroid	BHT101	8.9
Thyroid	CAL62	9.6
Thyroid	CGTHW1	10.6
Thyroid	FTC133	10.1
Thyroid	FTC238	9.5
Thyroid	ML1	9.2
Thyroid	SW579	10.5
Thyroid	TT2609C02	10.2
Thyroid	TT	8.8
Upper aerodigestive tract	BHY	9.2
Upper aerodigestive tract	BICR16	9.5
Upper aerodigestive tract	BICR18	9.9
Upper aerodigestive tract	BICR22	9
Upper aerodigestive tract	BICR31	9.9
Upper aerodigestive tract	BICR56	8.8
Upper aerodigestive tract	BICR6	9.6
Upper aerodigestive tract	CAL27	9
Upper aerodigestive tract	CAL33	8.6
Upper aerodigestive tract	DETROIT562	10
Upper aerodigestive tract	FADU	8.8
Upper aerodigestive tract	HS840T	9.9
Upper aerodigestive tract	HSC2	10.4
Upper aerodigestive tract	HSC3	9.8
Upper aerodigestive tract	HSC4	9.4
Upper aerodigestive tract	PECAPJ15	9.9
Upper aerodigestive tract	PECAPJ34CLONEC12	9.4
Upper aerodigestive tract	PECAPJ41CLONED2	10.1
Upper aerodigestive tract	PECAPJ49	9.7
Upper aerodigestive tract	SCC15	9.4
Upper aerodigestive tract	SCC25	10.9
Upper aerodigestive tract	SCC4	9.5
Upper aerodigestive tract	SCC9	8.4
Upper aerodigestive tract	SNU1076	10.4
Upper aerodigestive tract	SNU1214	9
Upper aerodigestive tract	SNU46	10.5
Upper aerodigestive tract	SNU899	10
Upper aerodigestive tract	YD10B	10.8
Upper aerodigestive tract	YD38	10.2
Upper aerodigestive tract	YD8	9.6
Urinary tract	5637	10.2
Urinary tract	639V	10
Urinary tract	647V	10.5
Urinary tract	BC3C	10.4
Urinary tract	BFTC905	9.5
Urinary tract	CAL29	10.1
Urinary tract	HS172T	9.8
Urinary tract	HT1197	9.5
Urinary tract	HT1376	10.6
Urinary tract	J82	10.7
Urinary tract	JMSU1	10.5
Urinary tract	KMBC2	9.8
Urinary tract	KU1919	9.7
Urinary tract	RT11284	9.3
Urinary tract	RT112	9.2
Urinary tract	RT4	10.1
Urinary tract	SCABER	9.3
Urinary tract	SW1710	9.4
Urinary tract	SW780	10.2
Urinary tract	T24	10
Urinary tract	TCCSUP	9.9
Urinary tract	UMUC1	9.3
Urinary tract	UMUC3	10.1
Urinary tract	VMCUB1	10

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	29.3
Adrenal gland	24.1
Appendix	23.3
Bone marrow	19.8
Breast	26.8
Cerebral cortex	33.7
Cervix, uterine	29.7
Colon	23.1
Duodenum	17.2
Endometrium	36.8
Epididymis	20.5
Esophagus	26.2
Fallopian tube	31.6
Gallbladder	26.2
Heart muscle	14.1
Kidney	24.5
Liver	12
Lung	27.2
Lymph node	31.3
Ovary	31
Pancreas	3
Parathyroid gland	47.4
Placenta	30.2
Prostate	31.3
Rectum	25.5
Salivary gland	8.2
Seminal vesicle	29
Skeletal muscle	10.1
Skin	23.4
Small intestine	19.3
Smooth muscle	35
Spleen	25.1
Stomach	20.2
Testis	74.5
Thyroid gland	35.9
Tonsil	26.8
Urinary bladder	23.7

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
25258321	Overexpression (copy number gain)	Breast Carcinoma	We found that increased ASH2L expression, which can result from gene amplification, is often correlated with increased ERα expression in both breast cancer cell lines and primary breast cancers.
23117580	Underexpression	Breast Carcinoma	The decrease in histone H3K4me3 at global and gene-specific levels correlated with reduced expression of SETD1 and ASH2L, genes encoding the histone H3K4 methyltransferase complex.

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.845	2.12e-111	36.6	33.7	29.7	Loss
BRCA	Breast invasive carcinoma	1075	0.912	0	24.7	37.6	37.8	Gain
CESC	Cervical and endocervical cancers	292	0.712	2.3e-46	21.2	61.3	17.5	Neutral
COAD	Colon adenocarcinoma	449	0.756	3.08e-84	21.6	45.4	33	Neutral
ESCA	Esophageal carcinoma	183	0.826	7.16e-47	27.9	32.2	39.9	Gain
GBM	Glioblastoma multiforme	147	0.649	6.55e-19	10.9	78.9	10.2	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.842	3.74e-139	34.6	35.6	29.8	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.599	2.44e-52	25.5	68.8	5.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.547	6.91e-24	4.9	88.2	6.9	Neutral
LAML	Acute Myeloid Leukemia	166	0.509	2.5e-12	0	89.2	10.8	Neutral
LGG	Brain Lower Grade Glioma	513	0.471	1.08e-29	2.9	89.1	8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.783	9.28e-77	56.9	30.8	12.4	Loss
LUAD	Lung adenocarcinoma	512	0.827	1.11e-129	34.6	39.3	26.2	Loss
LUSC	Lung squamous cell carcinoma	498	0.88	7.01e-163	28.9	27.5	43.6	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.814	2.41e-72	43	35	22	Loss
PAAD	Pancreatic adenocarcinoma	177	0.751	2.24e-33	23.2	59.3	17.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.565	5.07e-15	13	80.2	6.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.828	4.5e-125	33.6	52.3	14.1	Loss
READ	Rectum adenocarcinoma	164	0.795	4.72e-37	30.5	40.9	28.7	Neutral
SARC	Sarcoma	255	0.571	1.75e-23	16.5	53.3	30.2	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.638	2.28e-43	19.6	50.1	30.2	Neutral
STAD	Stomach adenocarcinoma	413	0.805	3.52e-95	24.5	37.5	38	Gain
TGCT	Testicular Germ Cell Tumors	150	0.329	3.9e-05	8	19.3	72.7	Gain
THCA	Thyroid carcinoma	497	0.114	0.0111	0.8	98	1.2	Neutral
THYM	Thymoma	119	0.335	0.000197	0.8	89.9	9.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.677	2.83e-73	13.4	64.1	22.5	Neutral

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.463	0	17	408	-0.002	0.414	NS/NA
BRCA	Breast invasive carcinoma	-0.521	0	83	785	0	0.984	NS/NA
CESC	Cervical and endocervical cancers	-0.307	4.11e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.428	0	19	297	0.001	0.0381	NS/NA
ESCA	Esophageal carcinoma	-0.439	2.29e-10	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.246	0.0489	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.339	6.45e-16	20	522	-0.001	0.357	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.291	4.85e-08	24	319	0.003	4.46e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.31	5.21e-08	23	275	0.002	4.8e-07	NS/NA
LAML	Acute Myeloid Leukemia	-0.198	0.00963	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.115	0.00819	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.497	0	41	373	0.003	0.288	NS/NA
LUAD	Lung adenocarcinoma	-0.125	0.0062	21	456	0	0.955	NS/NA
LUSC	Lung squamous cell carcinoma	-0.552	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.75	0.0255	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.251	0.000636	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.327	5.42e-06	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.438	0	35	498	0.004	1.38e-11	NS/NA
READ	Rectum adenocarcinoma	-0.499	1.62e-07	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.39	7.45e-11	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.303	2.17e-11	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.347	7.57e-12	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.315	6.93e-05	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.099	0.0188	50	509	-0.001	0.481	NS/NA
THYM	Thymoma	-0.176	0.0527	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.233	4.17e-07	34	431	-0.003	0.383	NS/NA

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	1	Low
Breast	1	Low
Bronchus	1	Low
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	1	Low
Cervix, uterine	1	Low
Colon	2	Medium
Duodenum	1	Low
Endometrium	1	Low
Epididymis	1	Low
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	0	Not detected
Lung	0	Not detected
Lymph node	0	Not detected
Nasopharynx	1	Low
Oral mucosa	1	Low
Ovary	2	Medium
Pancreas	1	Low
Parathyroid gland	0	Not detected
Placenta	2	Medium
Prostate	1	Low
Rectum	2	Medium
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	1	Low
Small intestine	2	Medium
Smooth muscle	0	Not detected
Soft tissue	1	Low
Spleen	0	Not detected
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.206	NS	24476821
BRCA	Breast invasive carcinoma	521	2.07e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.157	NS	22810696
GBM	Glioblastoma multiforme	157	0.541	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.16e-05	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00128	Significant	26536169
LGG	Brain Lower Grade Glioma	513	7.67e-08	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.000116	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.134	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.109	NS	21720365
PRAD	Prostate adenocarcinoma	333	0.0205	Significant	26544944
READ	Rectum adenocarcinoma	67	0.826	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.695	NS	26091043
STAD	Stomach adenocarcinoma	277	2.17e-07	Significant	25079317
THCA	Thyroid carcinoma	391	5.77e-12	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.169	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.347	0.158	NS
BRCA	Breast invasive carcinoma	1079	0.965	0.868	NS
CESC	Cervical and endocervical cancers	291	0.664	0.261	NS
COAD	Colon adenocarcinoma	439	0.583	0.0436	Longer
ESCA	Esophageal carcinoma	184	0.596	0.136	NS
GBM	Glioblastoma multiforme	158	0.84	0.494	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.637	0.0232	Longer
KIRC	Kidney renal clear cell carcinoma	531	0.548	0.0032	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.715	0.419	NS
LAML	Acute Myeloid Leukemia	149	1.109	0.724	NS
LGG	Brain Lower Grade Glioma	511	0.732	0.205	NS
LIHC	Liver hepatocellular carcinoma	365	0.887	0.618	NS
LUAD	Lung adenocarcinoma	502	1.261	0.266	NS
LUSC	Lung squamous cell carcinoma	494	0.589	0.00726	Longer
OV	Ovarian serous cystadenocarcinoma	303	0.932	0.741	NS
PAAD	Pancreatic adenocarcinoma	177	1.388	0.265	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.558	0.612	NS
PRAD	Prostate adenocarcinoma	497	0.131	0.028	Longer
READ	Rectum adenocarcinoma	159	0.491	0.172	NS
SARC	Sarcoma	259	1.159	0.598	NS
SKCM	Skin Cutaneous Melanoma	459	1.089	0.651	NS
STAD	Stomach adenocarcinoma	388	0.88	0.566	NS
TGCT	Testicular Germ Cell Tumors	134	640493686.283	0.143	NS
THCA	Thyroid carcinoma	500	0.18	0.0155	Longer
THYM	Thymoma	119	0	0.309	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.555	0.106	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.004	0.931	NS
BRCA	Breast invasive carcinoma	1071	0.069	0.0241	Higher
CESC	Cervical and endocervical cancers	167	0.054	0.491	NS
COAD	Colon adenocarcinoma	445	-0.149	0.00161	Lower
ESCA	Esophageal carcinoma	162	-0.069	0.382	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.094	0.0473	Lower
KIRC	Kidney renal clear cell carcinoma	531	-0.132	0.00235	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.059	0.341	NS
LIHC	Liver hepatocellular carcinoma	347	-0.028	0.605	NS
LUAD	Lung adenocarcinoma	507	-0.024	0.585	NS
LUSC	Lung squamous cell carcinoma	497	-0.022	0.631	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.006	0.914	NS
PAAD	Pancreatic adenocarcinoma	176	0.161	0.0327	Higher
READ	Rectum adenocarcinoma	156	0.042	0.6	NS
SKCM	Skin Cutaneous Melanoma	410	-0.1	0.0439	Lower
STAD	Stomach adenocarcinoma	392	-0.172	0.000646	Lower
TGCT	Testicular Germ Cell Tumors	81	-0.047	0.677	NS
THCA	Thyroid carcinoma	499	0.081	0.0709	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.048	0.286	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.071	0.242	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.077	0.0875	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.172	7.17e-05	Lower
LGG	Brain Lower Grade Glioma	514	0.053	0.233	NS
LIHC	Liver hepatocellular carcinoma	366	0.017	0.741	NS
OV	Ovarian serous cystadenocarcinoma	296	0.033	0.566	NS
PAAD	Pancreatic adenocarcinoma	176	0.148	0.05	Higher
STAD	Stomach adenocarcinoma	406	0.019	0.701	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.146	0.000708	Higher

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

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Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

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There is no record for ASH2L.

Summary
Symbol	ASH2L
Name	ASH2 like histone lysine methyltransferase complex subunit
Aliases	ASH2L2; Bre2; ASH2L1; ash2 (absent, small, or homeotic, Drosophila, homolog)-like; ASH21; ASH2-like protein; ......
Location	8p11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25258321	Breast Carcinoma	partner	GATA3	Coactivator	This study established that ASH2L enhances ERα expression as a coactivator of GATA3 in breast cancers.
25258321	Breast Carcinoma	downstream	ERα	Positive regulation	We found that increased ASH2L expression, which can result from gene amplification, is often correlated with increased ERα expression in both breast cancer cell lines and primary breast cancers.; Forced expression of ASH2L induced ERα expression in mammary epithelial cells, whereas depletion of ASH2L suppressed ERα expression in breast cancer cells.