CR2Cancer

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00004 ATPase family associated with various cellular activities (AAA)
PF00439 Bromodomain

Function

May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	#	#	17998543

> Gene Ontology [ TOP ]
Biological Process	GO:0006342 chromatin silencing GO:0016458 gene silencing GO:0031935 regulation of chromatin silencing GO:0031936 negative regulation of chromatin silencing GO:0040029 regulation of gene expression, epigenetic GO:0045814 negative regulation of gene expression, epigenetic GO:0045815 positive regulation of gene expression, epigenetic GO:0060968 regulation of gene silencing GO:0060969 negative regulation of gene silencing GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization
Molecular Function	GO:0003682 chromatin binding GO:0016887 ATPase activity GO:0042393 histone binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3166347	c.1779A>G	p.E593E	Substitution - coding silent	Oesophagus
COSM5757126	c.583C>G	p.R195G	Substitution - Missense	Large_intestine
COSM3432091	c.624T>C	p.F208F	Substitution - coding silent	Large_intestine
COSM1313695	c.217G>C	p.A73P	Substitution - Missense	Urinary_tract
COSM4626121	c.1572C>T	p.R524R	Substitution - coding silent	Large_intestine
COSM461489	c.117C>G	p.L39L	Substitution - coding silent	Cervix
COSM3675037	c.2597G>T	p.W866L	Substitution - Missense	Prostate
COSM453958	c.2832T>G	p.P944P	Substitution - coding silent	Breast
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine
COSM486043	c.496G>T	p.G166C	Substitution - Missense	Kidney
COSM5049328	c.837T>A	p.D279E	Substitution - Missense	Oesophagus
COSM3896560	c.1297A>G	p.N433D	Substitution - Missense	Stomach
COSM1330331	c.3160G>C	p.D1054H	Substitution - Missense	Ovary
COSM1194517	c.3920A>C	p.Q1307P	Substitution - Missense	Lung
COSM1313694	c.516G>T	p.L172L	Substitution - coding silent	Urinary_tract
COSM5727589	c.4160G>A	p.S1387N	Substitution - Missense	Skin
COSM3929369	c.1618C>T	p.R540W	Substitution - Missense	Central_nervous_system
COSM1755550	c.3134C>T	p.T1045I	Substitution - Missense	Urinary_tract
COSM3833996	c.2388G>A	p.L796L	Substitution - coding silent	Breast
COSM1095767	c.1210C>T	p.R404*	Substitution - Nonsense	Endometrium
COSM4390015	c.798T>A	p.D266E	Substitution - Missense	Urinary_tract
COSM3718788	c.4090_4091insT	p.Y1364fs*8	Insertion - Frameshift	Upper_aerodigestive_tract
COSM4996895	c.3150G>C	p.L1050F	Substitution - Missense	Upper_aerodigestive_tract
COSM5408774	c.3913G>A	p.E1305K	Substitution - Missense	Skin
COSM1095767	c.1210C>T	p.R404*	Substitution - Nonsense	Skin
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Lung
COSM4453524	c.3072A>T	p.V1024V	Substitution - coding silent	Skin
COSM3896563	c.792T>A	p.D264E	Substitution - Missense	Stomach
COSM4609825	c.2897_2898ins32	p.E966fs*3	Insertion - Frameshift	Adrenal_gland
COSM1623571	c.2587C>A	p.H863N	Substitution - Missense	Liver
COSM3644823	c.3647G>A	p.G1216E	Substitution - Missense	Skin
COSM1238249	c.1722G>A	p.T574T	Substitution - coding silent	Oesophagus
COSM1454651	c.1540C>T	p.R514*	Substitution - Nonsense	Large_intestine
COSM3166319	c.3357C>T	p.A1119A	Substitution - coding silent	Large_intestine
COSM3644832	c.1334C>T	p.P445L	Substitution - Missense	Skin
COSM749488	c.2332C>T	p.L778F	Substitution - Missense	Lung
COSM1623573	c.843A>T	p.E281D	Substitution - Missense	Liver
COSM1095774	c.467G>A	p.R156Q	Substitution - Missense	Large_intestine
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Stomach
COSM1183854	c.553C>G	p.L185V	Substitution - Missense	Large_intestine
COSM5811387	c.1504C>T	p.L502L	Substitution - coding silent	Liver
COSM5049328	c.837T>A	p.D279E	Substitution - Missense	Oesophagus
COSM1095756	c.2375G>A	p.R792Q	Substitution - Missense	Endometrium
COSM5062864	c.2794T>A	p.F932I	Substitution - Missense	Stomach
COSM3896551	c.3215G>A	p.R1072H	Substitution - Missense	Stomach
COSM749487	c.2206G>C	p.D736H	Substitution - Missense	Lung
COSM1095757	c.2323T>G	p.F775V	Substitution - Missense	Endometrium
COSM3778874	c.607G>C	p.E203Q	Substitution - Missense	Urinary_tract
COSM2149974	c.2389A>G	p.I797V	Substitution - Missense	Central_nervous_system
COSM296743	c.3360G>A	p.P1120P	Substitution - coding silent	Large_intestine
COSM1623570	c.3478+8C>T	p.?	Unknown	Liver
COSM3698818	c.463C>T	p.R155C	Substitution - Missense	Large_intestine
COSM4979535	c.1498G>C	p.D500H	Substitution - Missense	Oesophagus
COSM5967895	c.147C>A	p.P49P	Substitution - coding silent	Genital_tract
COSM749491	c.3792G>C	p.L1264F	Substitution - Missense	Lung
COSM5634060	c.3046G>A	p.D1016N	Substitution - Missense	Breast
COSM4150509	c.1646+6A>T	p.?	Unknown	Ovary
COSM4387347	c.3322A>G	p.R1108G	Substitution - Missense	Lung
COSM3644830	c.2381G>A	p.R794K	Substitution - Missense	Skin
COSM453960	c.2189G>A	p.R730K	Substitution - Missense	Breast
COSM5062865	c.807_818del12	p.D274_D277delDDDD	Deletion - In frame	Stomach
COSM453961	c.1857A>G	p.P619P	Substitution - coding silent	Breast
COSM1095769	c.1160G>A	p.C387Y	Substitution - Missense	Endometrium
COSM1183855	c.4130A>G	p.Q1377R	Substitution - Missense	Large_intestine
COSM3166396	c.40T>C	p.S14P	Substitution - Missense	Large_intestine
COSM3778872	c.1366A>T	p.K456*	Substitution - Nonsense	Urinary_tract
COSM5907468	c.1091C>T	p.S364F	Substitution - Missense	Skin
COSM3896554	c.2546C>G	p.A849G	Substitution - Missense	Stomach
COSM4444149	c.834A>T	p.E278D	Substitution - Missense	Pancreas
COSM4914962	c.30G>A	p.L10L	Substitution - coding silent	Liver
COSM1095762	c.1783C>A	p.L595I	Substitution - Missense	Endometrium
COSM3929368	c.1982C>G	p.T661S	Substitution - Missense	Central_nervous_system
COSM1488978	c.1243G>C	p.D415H	Substitution - Missense	Breast
COSM749482	c.50C>A	p.S17*	Substitution - Nonsense	Lung
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Pancreas
COSM3374762	c.1738A>G	p.I580V	Substitution - Missense	Thyroid
COSM1095744	c.4099C>T	p.R1367C	Substitution - Missense	Endometrium
COSM357428	c.1958G>C	p.R653P	Substitution - Missense	Lung
COSM1095758	c.2219C>A	p.S740Y	Substitution - Missense	Endometrium
COSM1623571	c.2587C>A	p.H863N	Substitution - Missense	Liver
COSM4883525	c.2260G>T	p.D754Y	Substitution - Missense	Upper_aerodigestive_tract
COSM4968097	c.2605G>T	p.V869F	Substitution - Missense	Adrenal_gland
COSM4150509	c.1646+6A>T	p.?	Unknown	Ovary
COSM1095772	c.592C>T	p.R198*	Substitution - Nonsense	Endometrium
COSM274064	c.637G>T	p.E213*	Substitution - Nonsense	Large_intestine
COSM1095775	c.429A>G	p.E143E	Substitution - coding silent	Endometrium
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine
COSM4800898	c.2231T>A	p.L744Q	Substitution - Missense	Liver
COSM5634060	c.3046G>A	p.D1016N	Substitution - Missense	Oesophagus
COSM1183857	c.3931A>G	p.T1311A	Substitution - Missense	Large_intestine
COSM3166304	c.3909G>T	p.Q1303H	Substitution - Missense	Large_intestine
COSM5429106	c.878G>A	p.R293Q	Substitution - Missense	Oesophagus
COSM1454656	c.825T>A	p.D275E	Substitution - Missense	Stomach
COSM301717	c.2764C>A	p.Q922K	Substitution - Missense	Central_nervous_system
COSM5047107	c.355_356insA	p.E120fs*17	Insertion - Frameshift	Oesophagus
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Liver
COSM1454658	c.810T>C	p.D270D	Substitution - coding silent	Large_intestine
COSM3166304	c.3909G>T	p.Q1303H	Substitution - Missense	Large_intestine
COSM3686369	c.640-3delT	p.?	Unknown	Large_intestine
COSM1330330	c.2689G>C	p.D897H	Substitution - Missense	Ovary
COSM4444149	c.834A>T	p.E278D	Substitution - Missense	Oesophagus
COSM219229	c.3196G>T	p.D1066Y	Substitution - Missense	Breast
COSM1454647	c.1777G>T	p.E593*	Substitution - Nonsense	Large_intestine
COSM5036954	c.3782G>A	p.C1261Y	Substitution - Missense	Oesophagus
COSM1238250	c.2536A>G	p.I846V	Substitution - Missense	Oesophagus
COSM3833995	c.2833C>G	p.P945A	Substitution - Missense	Breast
COSM309323	c.4132-2A>G	p.?	Unknown	Lung
COSM5618602	c.2374C>T	p.R792*	Substitution - Nonsense	Breast
COSM3896548	c.4024A>T	p.K1342*	Substitution - Nonsense	Stomach
COSM3644826	c.3044C>G	p.P1015R	Substitution - Missense	Skin
COSM77304	c.3823T>A	p.S1275T	Substitution - Missense	Ovary
COSM3644829	c.2494G>T	p.G832*	Substitution - Nonsense	Skin
COSM5508091	c.1970A>G	p.Q657R	Substitution - Missense	Biliary_tract
COSM3644831	c.2204T>A	p.L735*	Substitution - Nonsense	Skin
COSM4396489	c.2225C>T	p.P742L	Substitution - Missense	Skin
COSM5997855	c.2992C>T	p.H998Y	Substitution - Missense	Prostate
COSM1454649	c.1590_1591insT	p.D531fs*1	Insertion - Frameshift	Pancreas
COSM366707	c.3937G>C	p.E1313Q	Substitution - Missense	Lung
COSM749483	c.67G>T	p.D23Y	Substitution - Missense	Lung
COSM238875	c.3621C>A	p.D1207E	Substitution - Missense	Prostate
COSM1095760	c.2017A>C	p.N673H	Substitution - Missense	Endometrium
COSM3166380	c.414C>T	p.I138I	Substitution - coding silent	Skin
COSM1095767	c.1210C>T	p.R404*	Substitution - Nonsense	Skin
COSM453962	c.933A>G	p.K311K	Substitution - coding silent	Breast
COSM3166304	c.3909G>T	p.Q1303H	Substitution - Missense	Large_intestine
COSM4150510	c.709A>T	p.N237Y	Substitution - Missense	Ovary
COSM1454661	c.638_639+1delAAG	p.?	Unknown	Large_intestine
COSM1095748	c.2812C>A	p.L938I	Substitution - Missense	Endometrium
COSM4984491	c.2944G>C	p.E982Q	Substitution - Missense	Oesophagus
COSM219229	c.3196G>T	p.D1066Y	Substitution - Missense	Breast
COSM1454656	c.825T>A	p.D275E	Substitution - Missense	Stomach
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine
COSM265555	c.2642_2643delTA	p.L881fs*16	Deletion - Frameshift	Large_intestine
COSM1292610	c.2849A>G	p.K950R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1095745	c.3696C>T	p.A1232A	Substitution - coding silent	Endometrium
COSM378548	c.1752A>G	p.L584L	Substitution - coding silent	Lung
COSM1183856	c.2725G>T	p.E909*	Substitution - Nonsense	Large_intestine
COSM5929010	c.995G>A	p.R332K	Substitution - Missense	Skin
COSM5048743	c.3247G>C	p.D1083H	Substitution - Missense	Oesophagus
COSM3644829	c.2494G>T	p.G832*	Substitution - Nonsense	Skin
COSM5690914	c.1086A>G	p.S362S	Substitution - coding silent	Soft_tissue
COSM3644828	c.2690A>G	p.D897G	Substitution - Missense	Skin
COSM3166382	c.375A>T	p.K125N	Substitution - Missense	Large_intestine
COSM1755551	c.2626A>T	p.T876S	Substitution - Missense	Urinary_tract
COSM3166387	c.294A>T	p.Q98H	Substitution - Missense	Bone
COSM4635568	c.2932C>T	p.L978L	Substitution - coding silent	Large_intestine
COSM1454653	c.1186G>T	p.E396*	Substitution - Nonsense	Large_intestine
COSM1095749	c.2754T>G	p.I918M	Substitution - Missense	Endometrium
COSM1095774	c.467G>A	p.R156Q	Substitution - Missense	Endometrium
COSM4915055	c.3850G>A	p.D1284N	Substitution - Missense	Liver
COSM4641272	c.125C>T	p.A42V	Substitution - Missense	Large_intestine
COSM4478945	c.227C>T	p.S76F	Substitution - Missense	Upper_aerodigestive_tract
COSM299707	c.1573C>T	p.P525S	Substitution - Missense	Large_intestine
COSM3896556	c.2098G>A	p.A700T	Substitution - Missense	Stomach
COSM4921899	c.738A>G	p.E246E	Substitution - coding silent	Liver
COSM1095774	c.467G>A	p.R156Q	Substitution - Missense	Breast
COSM1623574	c.104G>A	p.G35D	Substitution - Missense	Liver
COSM2149974	c.2389A>G	p.I797V	Substitution - Missense	Central_nervous_system
COSM5997855	c.2992C>T	p.H998Y	Substitution - Missense	Prostate
COSM4445389	c.1266+3G>A	p.?	Unknown	Skin
COSM5901533	c.1967C>T	p.P656L	Substitution - Missense	Skin
COSM4663930	c.770G>A	p.G257D	Substitution - Missense	Large_intestine
COSM69741	c.3040G>C	p.D1014H	Substitution - Missense	Ovary
COSM3896553	c.2610A>G	p.G870G	Substitution - coding silent	Stomach
COSM1454654	c.1171A>C	p.N391H	Substitution - Missense	Large_intestine
COSM353569	c.460G>T	p.V154L	Substitution - Missense	Lung
COSM3644824	c.3551C>T	p.S1184L	Substitution - Missense	Skin
COSM4921723	c.1661C>T	p.T554I	Substitution - Missense	Liver
COSM3644825	c.3359C>T	p.P1120L	Substitution - Missense	Skin
COSM165984	c.2764_2765insT	p.Q922fs*5	Insertion - Frameshift	Breast
COSM5716293	c.3457C>T	p.P1153S	Substitution - Missense	Skin
COSM3166301	c.4030delA	p.S1344fs*15	Deletion - Frameshift	Pancreas
COSM1095753	c.2527G>A	p.A843T	Substitution - Missense	Endometrium
COSM3896557	c.1961G>A	p.R654H	Substitution - Missense	Stomach
COSM4444149	c.834A>T	p.E278D	Substitution - Missense	Upper_aerodigestive_tract
COSM1095755	c.2433A>G	p.P811P	Substitution - coding silent	Endometrium
COSM4996896	c.184G>T	p.V62F	Substitution - Missense	Upper_aerodigestive_tract
COSM1454652	c.1423_1424delCT	p.L475fs*8	Deletion - Frameshift	Large_intestine
COSM4760987	c.122C>T	p.S41L	Substitution - Missense	Stomach
COSM1313692	c.814G>C	p.D272H	Substitution - Missense	Urinary_tract
COSM5468650	c.3495A>G	p.K1165K	Substitution - coding silent	Large_intestine
COSM1177438	c.333A>G	p.R111R	Substitution - coding silent	Endometrium
COSM5778313	c.537-4A>T	p.?	Unknown	Breast
COSM4986748	c.17G>A	p.S6N	Substitution - Missense	Soft_tissue
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine
COSM1095746	c.3271G>T	p.E1091*	Substitution - Nonsense	Endometrium
COSM1238248	c.1651A>G	p.I551V	Substitution - Missense	Oesophagus
COSM5901534	c.1966C>T	p.P656S	Substitution - Missense	Skin
COSM1132854	c.3965C>A	p.P1322H	Substitution - Missense	Prostate
COSM5976622	c.833_834insTGATGA	p.D277_E278insDD	Insertion - In frame	Upper_aerodigestive_tract
COSM5472496	c.1557+6A>T	p.?	Unknown	Large_intestine
COSM5738426	c.238G>T	p.D80Y	Substitution - Missense	Small_intestine
COSM3896558	c.1753C>T	p.R585*	Substitution - Nonsense	Stomach
COSM3663544	c.2138T>C	p.V713A	Substitution - Missense	Liver
COSM5548056	c.932-3delT	p.?	Unknown	Prostate
COSM1095766	c.1361A>C	p.K454T	Substitution - Missense	Endometrium
COSM1095759	c.2037C>T	p.F679F	Substitution - coding silent	Endometrium
COSM1095754	c.2459T>G	p.F820C	Substitution - Missense	Endometrium
COSM5437721	c.3422C>G	p.P1141R	Substitution - Missense	Oesophagus
COSM749489	c.3007G>C	p.D1003H	Substitution - Missense	Lung
COSM3896552	c.3081A>G	p.Q1027Q	Substitution - coding silent	Stomach
COSM5408776	c.2736C>T	p.I912I	Substitution - coding silent	Skin
COSM1095768	c.1178G>A	p.R393Q	Substitution - Missense	Endometrium
COSM5908833	c.2174C>T	p.P725L	Substitution - Missense	Skin
COSM5954260	c.1522G>T	p.E508*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM1638323	c.1336T>C	p.L446L	Substitution - coding silent	Bone
COSM4778081	c.3916C>T	p.Q1306*	Substitution - Nonsense	Prostate
COSM3896562	c.941A>G	p.H314R	Substitution - Missense	Stomach
COSM5408775	c.3873G>A	p.M1291I	Substitution - Missense	Skin
COSM346039	c.1552G>C	p.D518H	Substitution - Missense	Lung
COSM421750	c.3406G>A	p.D1136N	Substitution - Missense	Urinary_tract
COSM1095771	c.816T>C	p.D272D	Substitution - coding silent	Endometrium
COSM3166305	c.3906C>T	p.S1302S	Substitution - coding silent	Large_intestine
COSM3951264	c.1741G>C	p.D581H	Substitution - Missense	Lung
COSM5716293	c.3457C>T	p.P1153S	Substitution - Missense	Skin
COSM5830820	c.833_834insTGA	p.D277_E278insD	Insertion - In frame	Large_intestine
COSM5763725	c.804T>C	p.D268D	Substitution - coding silent	Large_intestine
COSM1745351	c.831_833delTGA	p.D277delD	Deletion - In frame	Urinary_tract
COSM3382107	c.1177C>T	p.R393W	Substitution - Missense	Large_intestine
COSM5908834	c.2173C>T	p.P725S	Substitution - Missense	Skin
COSM3412736	c.853G>A	p.D285N	Substitution - Missense	Central_nervous_system
COSM268720	c.2993A>G	p.H998R	Substitution - Missense	Large_intestine
COSM5639146	c.3546G>A	p.K1182K	Substitution - coding silent	Oesophagus
COSM1755550	c.3134C>T	p.T1045I	Substitution - Missense	Urinary_tract
COSM4444149	c.834A>T	p.E278D	Substitution - Missense	Pancreas
COSM3166302	c.4019T>C	p.V1340A	Substitution - Missense	Oesophagus
COSM5685005	c.2736C>A	p.I912I	Substitution - coding silent	Soft_tissue
COSM5779770	c.3429G>T	p.Q1143H	Substitution - Missense	Breast
COSM453956	c.3768G>A	p.R1256R	Substitution - coding silent	Breast
COSM219229	c.3196G>T	p.D1066Y	Substitution - Missense	Breast
COSM749485	c.931A>C	p.K311Q	Substitution - Missense	Lung
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine
COSM3698818	c.463C>T	p.R155C	Substitution - Missense	Large_intestine
COSM4663929	c.2528C>T	p.A843V	Substitution - Missense	Large_intestine
COSM4849641	c.847G>A	p.E283K	Substitution - Missense	Cervix
COSM4663928	c.2827A>G	p.K943E	Substitution - Missense	Large_intestine
COSM3686368	c.789_797delAGATGATGA	p.E263_D265delEDD	Deletion - In frame	Large_intestine
COSM3833997	c.1099G>T	p.E367*	Substitution - Nonsense	Breast
COSM1095759	c.2037C>T	p.F679F	Substitution - coding silent	Endometrium
COSM1643498	c.1957C>T	p.R653*	Substitution - Nonsense	Stomach
COSM3896549	c.3918G>A	p.Q1306Q	Substitution - coding silent	Stomach
COSM3663544	c.2138T>C	p.V713A	Substitution - Missense	Liver
COSM4644831	c.1692C>T	p.S564S	Substitution - coding silent	Large_intestine
COSM1095774	c.467G>A	p.R156Q	Substitution - Missense	Endometrium
COSM274063	c.3808T>C	p.C1270R	Substitution - Missense	Large_intestine
COSM4800898	c.2231T>A	p.L744Q	Substitution - Missense	Liver
COSM1095752	c.2540G>A	p.R847H	Substitution - Missense	Endometrium
COSM3644833	c.382C>T	p.P128S	Substitution - Missense	Skin
COSM1095772	c.592C>T	p.R198*	Substitution - Nonsense	Large_intestine
COSM3951263	c.2345+10T>A	p.?	Unknown	Lung
COSM1193668	c.1816G>C	p.E606Q	Substitution - Missense	Lung
COSM1623570	c.3478+8C>T	p.?	Unknown	Liver
COSM4827014	c.706G>A	p.D236N	Substitution - Missense	Cervix
COSM5046077	c.3414A>T	p.R1138S	Substitution - Missense	Oesophagus
COSM5639145	c.3601G>A	p.D1201N	Substitution - Missense	Oesophagus
COSM5929009	c.2306A>T	p.H769L	Substitution - Missense	Skin
COSM3942505	c.419A>C	p.Q140P	Substitution - Missense	Oesophagus
COSM1569212	c.1047C>G	p.N349K	Substitution - Missense	Large_intestine
COSM4187303	c.52G>T	p.A18S	Substitution - Missense	Kidney
COSM4531915	c.1839G>A	p.R613R	Substitution - coding silent	Skin
COSM3896555	c.2435C>A	p.A812D	Substitution - Missense	Stomach
COSM421751	c.4111G>T	p.D1371Y	Substitution - Missense	Urinary_tract
COSM1095763	c.1666C>T	p.L556L	Substitution - coding silent	Endometrium
COSM1454663	c.354_355insA	p.E119fs*18	Insertion - Frameshift	Large_intestine
COSM3728917	c.537-5delT	p.?	Unknown	Stomach
COSM5727590	c.2970G>A	p.R990R	Substitution - coding silent	Skin
COSM3896564	c.464G>A	p.R155H	Substitution - Missense	Stomach
COSM5408777	c.1442C>T	p.A481V	Substitution - Missense	Skin
COSM1454650	c.1590delT	p.F530fs*27	Deletion - Frameshift	Skin
COSM3644822	c.4003-1G>A	p.?	Unknown	Skin
COSM5512539	c.4093C>T	p.R1365W	Substitution - Missense	Biliary_tract
COSM3896550	c.3578C>T	p.A1193V	Substitution - Missense	Stomach
COSM4570289	c.2538T>C	p.I846I	Substitution - coding silent	Skin
COSM3382107	c.1177C>T	p.R393W	Substitution - Missense	Pancreas
COSM3374763	c.1658C>T	p.S553F	Substitution - Missense	Thyroid
COSM1660654	c.2773G>C	p.D925H	Substitution - Missense	Kidney
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine
COSM1700609	c.1345C>T	p.P449S	Substitution - Missense	Skin
COSM1454663	c.354_355insA	p.E119fs*18	Insertion - Frameshift	Large_intestine
COSM1095771	c.816T>C	p.D272D	Substitution - coding silent	Urinary_tract
COSM4780050	c.1594G>T	p.E532*	Substitution - Nonsense	Liver
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Stomach
COSM5896904	c.1482C>A	p.F494L	Substitution - Missense	Skin
COSM5441791	c.1320G>C	p.E440D	Substitution - Missense	Oesophagus
COSM1095764	c.1649C>A	p.S550Y	Substitution - Missense	Endometrium
COSM3698818	c.463C>T	p.R155C	Substitution - Missense	Oesophagus
COSM5690913	c.2446G>T	p.A816S	Substitution - Missense	Soft_tissue
COSM1454656	c.825T>A	p.D275E	Substitution - Missense	Urinary_tract
COSM1700608	c.3658G>T	p.E1220*	Substitution - Nonsense	Skin
COSM1095747	c.2976C>A	p.F992L	Substitution - Missense	Endometrium
COSM1579268	c.3586C>A	p.H1196N	Substitution - Missense	Fallopian_tube
COSM4950821	c.3987T>A	p.D1329E	Substitution - Missense	Liver
COSM749490	c.3031A>T	p.K1011*	Substitution - Nonsense	Lung
COSM4478945	c.227C>T	p.S76F	Substitution - Missense	Skin
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Biliary_tract
COSM1173378	c.3869-1G>C	p.?	Unknown	Oesophagus
COSM3833998	c.607G>A	p.E203K	Substitution - Missense	Breast
COSM1095765	c.1499_1500insA	p.D500fs*5	Insertion - Frameshift	Endometrium
COSM1755551	c.2626A>T	p.T876S	Substitution - Missense	Urinary_tract
COSM1623572	c.2213-15_2214del17	p.?	Unknown	Liver
COSM3729433	c.1721C>T	p.T574M	Substitution - Missense	Stomach
COSM5467331	c.1640T>C	p.I547T	Substitution - Missense	Large_intestine
COSM3929367	c.2792A>G	p.K931R	Substitution - Missense	Central_nervous_system
COSM1454649	c.1590_1591insT	p.D531fs*1	Insertion - Frameshift	Large_intestine
COSM5976621	c.2057T>A	p.M686K	Substitution - Missense	Upper_aerodigestive_tract
COSM5773154	c.2286A>G	p.G762G	Substitution - coding silent	Breast
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine
COSM4826639	c.2163G>A	p.Q721Q	Substitution - coding silent	Cervix
COSM1095751	c.2613G>A	p.P871P	Substitution - coding silent	Endometrium
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine
COSM3644827	c.3019C>T	p.R1007*	Substitution - Nonsense	Skin
COSM4934931	c.817G>C	p.D273H	Substitution - Missense	Liver
COSM5459336	c.568G>A	p.D190N	Substitution - Missense	Large_intestine
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine
COSM1095774	c.467G>A	p.R156Q	Substitution - Missense	Large_intestine
COSM1319763	c.2770C>T	p.P924S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5886572	c.2447C>T	p.A816V	Substitution - Missense	Skin
COSM4950821	c.3987T>A	p.D1329E	Substitution - Missense	Liver
COSM4150511	c.298G>C	p.A100P	Substitution - Missense	Ovary
COSM1623571	c.2587C>A	p.H863N	Substitution - Missense	Liver
COSM1745351	c.831_833delTGA	p.D277delD	Deletion - In frame	Large_intestine
COSM1454662	c.392G>A	p.R131Q	Substitution - Missense	Large_intestine
COSM1095756	c.2375G>A	p.R792Q	Substitution - Missense	Large_intestine
COSM5026968	c.2889A>G	p.P963P	Substitution - coding silent	Breast
COSM5792554	c.3147T>G	p.Y1049*	Substitution - Nonsense	Breast
COSM1623574	c.104G>A	p.G35D	Substitution - Missense	Liver
COSM3778873	c.1186G>A	p.E396K	Substitution - Missense	Urinary_tract
COSM3166328	c.2969G>A	p.R990K	Substitution - Missense	Large_intestine
COSM1313691	c.1318G>C	p.E440Q	Substitution - Missense	Urinary_tract
COSM5979590	c.584G>A	p.R195H	Substitution - Missense	Upper_aerodigestive_tract
COSM1095761	c.1810C>T	p.R604*	Substitution - Nonsense	Endometrium
COSM1095773	c.585T>C	p.R195R	Substitution - coding silent	Endometrium
COSM3785863	c.488G>A	p.R163H	Substitution - Missense	Pancreas
COSM1095776	c.415G>A	p.V139I	Substitution - Missense	Endometrium
COSM1623573	c.843A>T	p.E281D	Substitution - Missense	Liver
COSM3896561	c.1269A>G	p.V423V	Substitution - coding silent	Stomach
COSM243092	c.3331A>C	p.R1111R	Substitution - coding silent	Prostate
COSM3644834	c.109A>C	p.R37R	Substitution - coding silent	Skin
COSM229114	c.2518G>A	p.E840K	Substitution - Missense	Skin
COSM1623570	c.3478+8C>T	p.?	Unknown	Liver
COSM749484	c.403G>A	p.A135T	Substitution - Missense	Lung
COSM1454644	c.4023T>A	p.V1341V	Substitution - coding silent	Large_intestine
COSM1643498	c.1957C>T	p.R653*	Substitution - Nonsense	Stomach
COSM5776270	c.3616C>T	p.Q1206*	Substitution - Nonsense	Breast
COSM1095770	c.1138C>T	p.R380C	Substitution - Missense	Endometrium
COSM749486	c.1525T>A	p.S509T	Substitution - Missense	Lung
COSM119905	c.1744C>A	p.P582T	Substitution - Missense	Ovary
COSM4444149	c.834A>T	p.E278D	Substitution - Missense	Large_intestine
COSM1095750	c.2657C>A	p.S886*	Substitution - Nonsense	Endometrium
COSM1095744	c.4099C>T	p.R1367C	Substitution - Missense	Large_intestine
COSM1238251	c.3449C>T	p.P1150L	Substitution - Missense	Oesophagus
COSM1313693	c.736G>A	p.E246K	Substitution - Missense	Urinary_tract
COSM3729433	c.1721C>T	p.T574M	Substitution - Missense	Large_intestine
COSM1163754	c.3536delA	p.K1179fs*16	Deletion - Frameshift	Pancreas
COSM5635821	c.3754C>G	p.L1252V	Substitution - Missense	Oesophagus
COSM3166395	c.42C>T	p.S14S	Substitution - coding silent	Bone
COSM3896559	c.1366A>G	p.K456E	Substitution - Missense	Stomach
COSM4428741	c.3543G>T	p.R1181S	Substitution - Missense	Oesophagus
COSM6013275	c.536+1G>A	p.?	Unknown	Skin
COSM4836073	c.1022G>A	p.R341K	Substitution - Missense	Cervix
COSM453957	c.3245G>C	p.R1082T	Substitution - Missense	Breast
COSM3166382	c.375A>T	p.K125N	Substitution - Missense	Large_intestine
COSM3951265	c.280G>A	p.E94K	Substitution - Missense	Lung
COSM5004473	c.4100G>A	p.R1367H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Oesophagus
COSM1095748	c.2812C>A	p.L938I	Substitution - Missense	Large_intestine
COSM3432090	c.3014G>A	p.R1005Q	Substitution - Missense	Large_intestine
COSM5553253	c.928G>T	p.E310*	Substitution - Nonsense	Prostate
COSM3924588	c.1027C>T	p.P343S	Substitution - Missense	Skin
COSM203096	c.354delA	p.E119fs*8	Deletion - Frameshift	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for ATAD2.

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q6PL18	61	S	Phosphoserine	-	No	None detected
Q6PL18	165	S	Phosphoserine	-	No	None detected
Q6PL18	170	S	Phosphoserine	-	No	None detected
Q6PL18	327	S	Phosphoserine	-	No	None detected
Q6PL18	337	S	Phosphoserine	-	No	None detected
Q6PL18	342	S	Phosphoserine	-	No	None detected
Q6PL18	410	S	Phosphoserine	-	No	None detected
Q6PL18	746	S	Phosphoserine	-	No	None detected
Q6PL18	751	S	Phosphoserine	-	No	None detected
Q6PL18	1139	S	Phosphoserine	-	Yes	p.S1139* (cancer: BLCA)
Q6PL18	1149	T	Phosphothreonine	-	No	None detected
Q6PL18	1152	T	Phosphothreonine	-	No	None detected
Q6PL18	1176	T	Phosphothreonine	-	No	None detected
Q6PL18	1200	S	Phosphoserine	-	No	None detected
Q6PL18	1233	S	Phosphoserine	-	No	None detected
Q6PL18	1235	S	Phosphoserine	-	No	None detected
Q6PL18	1243	S	Phosphoserine	-	No	None detected
Q6PL18	1302	S	Phosphoserine	-	No	None detected
Q6PL18	1323	T	Phosphothreonine	-	No	None detected

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.242	5.804	1.41	2.05e-09	Over
BRCA	Breast invasive carcinoma	112	1100	4.383	6.218	1.78	2.27e-55	Over
CESC	Cervical and endocervical cancers	3	306	3.264	6.77	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.114	5.749	1.539	1.32e-28	Over
ESCA	Esophageal carcinoma	11	185	4.922	6.624	1.511	9.91e-08	Over
GBM	Glioblastoma multiforme	5	166	3.144	5.079	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.625	5.883	1.53	4.7e-29	Over
KIRC	Kidney renal clear cell carcinoma	72	534	2.861	3.729	0.825	9.69e-18	Over
KIRP	Kidney renal papillary cell carcinoma	32	291	2.333	2.802	0.554	0.00449	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.826	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.556	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.706	5.203	1.429	1.16e-16	Over
LUAD	Lung adenocarcinoma	59	517	3.696	5.387	1.607	1.18e-29	Over
LUSC	Lung squamous cell carcinoma	51	501	3.809	6.18	2.28	1.05e-83	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.99	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.348	4.412	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	3.146	3.956	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.115	5.099	-0.007	0.951	NS
READ	Rectum adenocarcinoma	10	167	4.453	5.803	1.262	2.06e-05	Over
SARC	Sarcoma	2	263	2.817	5.446	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.16	5.477	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	3.851	6.108	1.962	2.45e-29	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.963	NA	NA	NA
THCA	Thyroid carcinoma	59	509	3.786	4.625	0.737	5.75e-19	Over
THYM	Thymoma	2	120	6.08	5.813	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	3.544	5.026	1.34	1.68e-11	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.6
Autonomic ganglia	CHP212	9.3
Autonomic ganglia	IMR32	9.8
Autonomic ganglia	KELLY	10.1
Autonomic ganglia	KPNRTBM1	9.7
Autonomic ganglia	KPNSI9S	9.1
Autonomic ganglia	KPNYN	9.9
Autonomic ganglia	MHHNB11	9.4
Autonomic ganglia	NB1	10
Autonomic ganglia	NH6	9.4
Autonomic ganglia	SHSY5Y	9.1
Autonomic ganglia	SIMA	9.6
Autonomic ganglia	SKNAS	8.7
Autonomic ganglia	SKNBE2	9.8
Autonomic ganglia	SKNDZ	10.1
Autonomic ganglia	SKNFI	9
Autonomic ganglia	SKNSH	8.8
Biliary tract	HUCCT1	10.2
Biliary tract	HUH28	8.5
Biliary tract	SNU1079	9.2
Biliary tract	SNU1196	10.9
Biliary tract	SNU245	9.9
Biliary tract	SNU308	8.8
Biliary tract	SNU478	8.7
Bone	143B	10.2
Bone	A673	10.6
Bone	CADOES1	10.4
Bone	CAL78	9.8
Bone	G292CLONEA141B1	10.9
Bone	HOS	10
Bone	HS706T	8.5
Bone	HS737T	7.3
Bone	HS819T	7.2
Bone	HS821T	8.2
Bone	HS822T	7
Bone	HS863T	9.3
Bone	HS870T	9.4
Bone	HS888T	8.9
Bone	MG63	10.5
Bone	MHHES1	10.2
Bone	OUMS27	9.5
Bone	RDES	9.9
Bone	SJSA1	9.7
Bone	SKES1	10.4
Bone	SKNMC	10.9
Bone	SW1353	8.4
Bone	T173	8.7
Bone	TC71	9.8
Bone	U2OS	10.7
Breast	AU565	11.8
Breast	BT20	9.2
Breast	BT474	10.4
Breast	BT483	10.4
Breast	BT549	10.2
Breast	CAL120	9.3
Breast	CAL148	8.3
Breast	CAL51	10.2
Breast	CAL851	9.4
Breast	CAMA1	10.3
Breast	DU4475	10.2
Breast	EFM192A	12.1
Breast	EFM19	10.2
Breast	EVSAT	10.8
Breast	HCC1143	10.8
Breast	HCC1187	9.9
Breast	HCC1395	11.1
Breast	HCC1419	12
Breast	HCC1428	11.8
Breast	HCC1500	10.7
Breast	HCC1569	9.6
Breast	HCC1599	11.5
Breast	HCC1806	10.4
Breast	HCC1937	10.8
Breast	HCC1954	11.1
Breast	HCC202	10.5
Breast	HCC2157	10.2
Breast	HCC2218	9.6
Breast	HCC38	10.7
Breast	HCC70	10.9
Breast	HDQP1	10.2
Breast	HMC18	10
Breast	HS274T	8.9
Breast	HS281T	8.8
Breast	HS343T	9.3
Breast	HS578T	9.7
Breast	HS606T	7.8
Breast	HS739T	8
Breast	HS742T	6.8
Breast	JIMT1	10.4
Breast	KPL1	10.8
Breast	MCF7	10.7
Breast	MDAMB134VI	9.9
Breast	MDAMB157	11.3
Breast	MDAMB175VII	9
Breast	MDAMB231	10
Breast	MDAMB361	9.9
Breast	MDAMB415	9.4
Breast	MDAMB436	9.8
Breast	MDAMB453	11
Breast	MDAMB468	9.4
Breast	SKBR3	12
Breast	T47D	10.4
Breast	UACC812	10.1
Breast	UACC893	9.3
Breast	YMB1	9.2
Breast	ZR751	10.1
Breast	ZR7530	11.4
Central nervous system	1321N1	9.9
Central nervous system	42MGBA	9.9
Central nervous system	8MGBA	9.9
Central nervous system	A172	9.2
Central nervous system	AM38	9.9
Central nervous system	BECKER	9.4
Central nervous system	CAS1	8.4
Central nervous system	CCFSTTG1	10.4
Central nervous system	D283MED	11.1
Central nervous system	D341MED	8.7
Central nervous system	DAOY	9.6
Central nervous system	DBTRG05MG	8.5
Central nervous system	DKMG	9
Central nervous system	GAMG	9.9
Central nervous system	GB1	10.2
Central nervous system	GI1	10.3
Central nervous system	GMS10	10.3
Central nervous system	GOS3	9
Central nervous system	H4	8.8
Central nervous system	HS683	9.3
Central nervous system	KALS1	9.2
Central nervous system	KG1C	7.7
Central nervous system	KNS42	8.6
Central nervous system	KNS60	9.6
Central nervous system	KNS81	9.4
Central nervous system	KS1	10.2
Central nervous system	LN18	9.6
Central nervous system	LN229	10.1
Central nervous system	M059K	9.1
Central nervous system	MOGGCCM	9
Central nervous system	MOGGUVW	9.7
Central nervous system	NMCG1	9.3
Central nervous system	ONS76	9.4
Central nervous system	SF126	9.7
Central nervous system	SF295	9.3
Central nervous system	SNB19	10.4
Central nervous system	SNU1105	9.1
Central nervous system	SNU201	8.8
Central nervous system	SNU466	7.9
Central nervous system	SNU489	6.3
Central nervous system	SNU626	8.6
Central nervous system	SNU738	9.8
Central nervous system	SW1088	9.6
Central nervous system	SW1783	9.4
Central nervous system	T98G	9.8
Central nervous system	TM31	10
Central nervous system	U118MG	9.6
Central nervous system	U138MG	9.4
Central nervous system	U251MG	9
Central nervous system	U87MG	9
Central nervous system	YH13	8.5
Central nervous system	YKG1	9.5
Endometrium	AN3CA	8.7
Endometrium	COLO684	11.3
Endometrium	EFE184	9
Endometrium	EN	10.1
Endometrium	ESS1	10.3
Endometrium	HEC108	9.3
Endometrium	HEC151	10.1
Endometrium	HEC1A	10.4
Endometrium	HEC1B	10.5
Endometrium	HEC251	9.4
Endometrium	HEC265	9.5
Endometrium	HEC50B	10.9
Endometrium	HEC59	9.4
Endometrium	HEC6	9.5
Endometrium	ISHIKAWAHERAKLIO02ER	9.5
Endometrium	JHUEM1	9
Endometrium	JHUEM2	9.6
Endometrium	JHUEM3	9.8
Endometrium	KLE	8.3
Endometrium	MFE280	9.4
Endometrium	MFE296	8.6
Endometrium	MFE319	8.4
Endometrium	RL952	9.7
Endometrium	SNGM	8.5
Endometrium	SNU1077	9.1
Endometrium	SNU685	8.9
Endometrium	TEN	10.1
Haematopoietic and lymphoid	697	10.9
Haematopoietic and lymphoid	A3KAW	9.6
Haematopoietic and lymphoid	A4FUK	9.6
Haematopoietic and lymphoid	ALLSIL	11.3
Haematopoietic and lymphoid	AML193	10.3
Haematopoietic and lymphoid	AMO1	10.1
Haematopoietic and lymphoid	BCP1	8.9
Haematopoietic and lymphoid	BDCM	9.6
Haematopoietic and lymphoid	BL41	10.3
Haematopoietic and lymphoid	BL70	10.6
Haematopoietic and lymphoid	BV173	12.1
Haematopoietic and lymphoid	CA46	8.9
Haematopoietic and lymphoid	CI1	10.2
Haematopoietic and lymphoid	CMK115	9.8
Haematopoietic and lymphoid	CMK86	9.6
Haematopoietic and lymphoid	CMK	9.4
Haematopoietic and lymphoid	CMLT1	10
Haematopoietic and lymphoid	COLO775	9
Haematopoietic and lymphoid	DAUDI	10.1
Haematopoietic and lymphoid	DB	10.4
Haematopoietic and lymphoid	DEL	9.5
Haematopoietic and lymphoid	DND41	10.4
Haematopoietic and lymphoid	DOHH2	10.1
Haematopoietic and lymphoid	EB1	8.5
Haematopoietic and lymphoid	EB2	8.3
Haematopoietic and lymphoid	EHEB	8.8
Haematopoietic and lymphoid	EJM	10
Haematopoietic and lymphoid	EM2	10.8
Haematopoietic and lymphoid	EOL1	10.4
Haematopoietic and lymphoid	F36P	9.7
Haematopoietic and lymphoid	GA10	10
Haematopoietic and lymphoid	GDM1	10.3
Haematopoietic and lymphoid	GRANTA519	9.8
Haematopoietic and lymphoid	HDLM2	10.8
Haematopoietic and lymphoid	HDMYZ	10.3
Haematopoietic and lymphoid	HEL9217	10.8
Haematopoietic and lymphoid	HEL	10.5
Haematopoietic and lymphoid	HH	10.3
Haematopoietic and lymphoid	HL60	9.8
Haematopoietic and lymphoid	HPBALL	10.6
Haematopoietic and lymphoid	HS604T	7.1
Haematopoietic and lymphoid	HS611T	10.3
Haematopoietic and lymphoid	HS616T	7.8
Haematopoietic and lymphoid	HS751T	8.9
Haematopoietic and lymphoid	HT	10.2
Haematopoietic and lymphoid	HTK	9.8
Haematopoietic and lymphoid	HUNS1	9.7
Haematopoietic and lymphoid	HUT102	9.6
Haematopoietic and lymphoid	HUT78	9.8
Haematopoietic and lymphoid	JEKO1	9.2
Haematopoietic and lymphoid	JK1	9.8
Haematopoietic and lymphoid	JM1	10
Haematopoietic and lymphoid	JURKAT	10.6
Haematopoietic and lymphoid	JURLMK1	12.8
Haematopoietic and lymphoid	JVM2	8.8
Haematopoietic and lymphoid	JVM3	8.6
Haematopoietic and lymphoid	K562	9.5
Haematopoietic and lymphoid	KARPAS299	9.7
Haematopoietic and lymphoid	KARPAS422	9.8
Haematopoietic and lymphoid	KARPAS620	9.7
Haematopoietic and lymphoid	KASUMI1	10.6
Haematopoietic and lymphoid	KASUMI2	10.1
Haematopoietic and lymphoid	KASUMI6	9.3
Haematopoietic and lymphoid	KCL22	11.2
Haematopoietic and lymphoid	KE37	11.4
Haematopoietic and lymphoid	KE97	10.2
Haematopoietic and lymphoid	KG1	11.2
Haematopoietic and lymphoid	KHM1B	10
Haematopoietic and lymphoid	KIJK	10.3
Haematopoietic and lymphoid	KMH2	9.6
Haematopoietic and lymphoid	KMM1	9.9
Haematopoietic and lymphoid	KMS11	10.1
Haematopoietic and lymphoid	KMS12BM	10.5
Haematopoietic and lymphoid	KMS18	10.4
Haematopoietic and lymphoid	KMS20	9.7
Haematopoietic and lymphoid	KMS21BM	8.8
Haematopoietic and lymphoid	KMS26	10.3
Haematopoietic and lymphoid	KMS27	10.4
Haematopoietic and lymphoid	KMS28BM	9.7
Haematopoietic and lymphoid	KMS34	10.3
Haematopoietic and lymphoid	KO52	10.1
Haematopoietic and lymphoid	KOPN8	9.9
Haematopoietic and lymphoid	KU812	10.3
Haematopoietic and lymphoid	KYO1	10
Haematopoietic and lymphoid	L1236	9.8
Haematopoietic and lymphoid	L363	11.1
Haematopoietic and lymphoid	L428	11
Haematopoietic and lymphoid	L540	10
Haematopoietic and lymphoid	LAMA84	11.2
Haematopoietic and lymphoid	LOUCY	10.4
Haematopoietic and lymphoid	LP1	7.5
Haematopoietic and lymphoid	M07E	10.9
Haematopoietic and lymphoid	MC116	9.9
Haematopoietic and lymphoid	ME1	9.4
Haematopoietic and lymphoid	MEC1	10.5
Haematopoietic and lymphoid	MEC2	10
Haematopoietic and lymphoid	MEG01	10.8
Haematopoietic and lymphoid	MHHCALL2	10.8
Haematopoietic and lymphoid	MHHCALL3	10.5
Haematopoietic and lymphoid	MHHCALL4	10.4
Haematopoietic and lymphoid	MINO	9.8
Haematopoietic and lymphoid	MJ	9.8
Haematopoietic and lymphoid	MM1S	10
Haematopoietic and lymphoid	MOLM13	11
Haematopoietic and lymphoid	MOLM16	9.1
Haematopoietic and lymphoid	MOLM6	9.9
Haematopoietic and lymphoid	MOLP2	7.4
Haematopoietic and lymphoid	MOLP8	8.8
Haematopoietic and lymphoid	MOLT13	11
Haematopoietic and lymphoid	MOLT16	10
Haematopoietic and lymphoid	MOLT4	10.4
Haematopoietic and lymphoid	MONOMAC1	10
Haematopoietic and lymphoid	MONOMAC6	10.5
Haematopoietic and lymphoid	MOTN1	8.7
Haematopoietic and lymphoid	MUTZ5	10.6
Haematopoietic and lymphoid	MV411	10.6
Haematopoietic and lymphoid	NALM19	10
Haematopoietic and lymphoid	NALM1	10.5
Haematopoietic and lymphoid	NALM6	11.2
Haematopoietic and lymphoid	NAMALWA	9.8
Haematopoietic and lymphoid	NB4	9.6
Haematopoietic and lymphoid	NCIH929	9.6
Haematopoietic and lymphoid	NCO2	10.7
Haematopoietic and lymphoid	NOMO1	10.2
Haematopoietic and lymphoid	NUDHL1	8.5
Haematopoietic and lymphoid	NUDUL1	10.4
Haematopoietic and lymphoid	OCIAML2	10.5
Haematopoietic and lymphoid	OCIAML3	10.1
Haematopoietic and lymphoid	OCIAML5	10.2
Haematopoietic and lymphoid	OCILY10	10.1
Haematopoietic and lymphoid	OCILY19	10
Haematopoietic and lymphoid	OCILY3	9.9
Haematopoietic and lymphoid	OCIM1	10.5
Haematopoietic and lymphoid	OPM2	9.8
Haematopoietic and lymphoid	P12ICHIKAWA	11
Haematopoietic and lymphoid	P31FUJ	9.5
Haematopoietic and lymphoid	P3HR1	10
Haematopoietic and lymphoid	PCM6	8.6
Haematopoietic and lymphoid	PEER	10.7
Haematopoietic and lymphoid	PF382	11.6
Haematopoietic and lymphoid	PFEIFFER	10.7
Haematopoietic and lymphoid	PL21	10.6
Haematopoietic and lymphoid	RAJI	9.8
Haematopoietic and lymphoid	RCHACV	10.8
Haematopoietic and lymphoid	REC1	9.2
Haematopoietic and lymphoid	REH	10.4
Haematopoietic and lymphoid	RI1	9.2
Haematopoietic and lymphoid	RL	10.1
Haematopoietic and lymphoid	RPMI8226	10.1
Haematopoietic and lymphoid	RPMI8402	10.9
Haematopoietic and lymphoid	RS411	10.5
Haematopoietic and lymphoid	SEM	10.6
Haematopoietic and lymphoid	SET2	9.5
Haematopoietic and lymphoid	SIGM5	10.8
Haematopoietic and lymphoid	SKM1	11.3
Haematopoietic and lymphoid	SKMM2	10.3
Haematopoietic and lymphoid	SR786	10.2
Haematopoietic and lymphoid	ST486	10.4
Haematopoietic and lymphoid	SUDHL10	10.6
Haematopoietic and lymphoid	SUDHL1	9.4
Haematopoietic and lymphoid	SUDHL4	9.4
Haematopoietic and lymphoid	SUDHL5	10.7
Haematopoietic and lymphoid	SUDHL6	10.9
Haematopoietic and lymphoid	SUDHL8	10.9
Haematopoietic and lymphoid	SUPB15	10.8
Haematopoietic and lymphoid	SUPHD1	9.3
Haematopoietic and lymphoid	SUPM2	10.2
Haematopoietic and lymphoid	SUPT11	11.4
Haematopoietic and lymphoid	SUPT1	10.6
Haematopoietic and lymphoid	TALL1	11.1
Haematopoietic and lymphoid	TF1	9.8
Haematopoietic and lymphoid	THP1	10.7
Haematopoietic and lymphoid	TO175T	8.8
Haematopoietic and lymphoid	TOLEDO	10.8
Haematopoietic and lymphoid	U266B1	9.7
Haematopoietic and lymphoid	U937	9.9
Haematopoietic and lymphoid	UT7	9
Haematopoietic and lymphoid	WSUDLCL2	10.8
Kidney	769P	9.9
Kidney	786O	9.9
Kidney	A498	8.6
Kidney	A704	8.6
Kidney	ACHN	9.1
Kidney	BFTC909	10.6
Kidney	CAKI1	9.1
Kidney	CAKI2	9.1
Kidney	CAL54	8.4
Kidney	KMRC1	9.4
Kidney	KMRC20	9.6
Kidney	KMRC2	9
Kidney	KMRC3	7.5
Kidney	OSRC2	8.3
Kidney	RCC10RGB	8.8
Kidney	SNU1272	8.7
Kidney	SNU349	7.9
Kidney	TUHR10TKB	9.1
Kidney	TUHR14TKB	7.7
Kidney	TUHR4TKB	7.9
Kidney	VMRCRCW	8.2
Kidney	VMRCRCZ	9.3
Large intestine	C2BBE1	9.3
Large intestine	CCK81	9.9
Large intestine	CL11	9.9
Large intestine	CL14	7.7
Large intestine	CL34	9.7
Large intestine	CL40	7.9
Large intestine	COLO205	10
Large intestine	COLO320	9.5
Large intestine	COLO678	9.7
Large intestine	CW2	9.4
Large intestine	DLD1	10.4
Large intestine	GP2D	9.4
Large intestine	HCC56	8.9
Large intestine	HCT116	10.5
Large intestine	HCT15	10.2
Large intestine	HS675T	8
Large intestine	HS698T	9
Large intestine	HT115	9.9
Large intestine	HT29	11
Large intestine	HT55	9.3
Large intestine	KM12	10
Large intestine	LOVO	9.8
Large intestine	LS1034	9.5
Large intestine	LS123	10.7
Large intestine	LS180	9.5
Large intestine	LS411N	9.7
Large intestine	LS513	9.1
Large intestine	MDST8	8.6
Large intestine	NCIH508	7.6
Large intestine	NCIH716	9.3
Large intestine	NCIH747	10.3
Large intestine	OUMS23	8
Large intestine	RCM1	9.4
Large intestine	RKO	10.9
Large intestine	SKCO1	10
Large intestine	SNU1040	6.5
Large intestine	SNU1197	9.1
Large intestine	SNU175	9.4
Large intestine	SNU283	9.7
Large intestine	SNU407	9.8
Large intestine	SNU503	9.1
Large intestine	SNU61	11.2
Large intestine	SNU81	9.2
Large intestine	SNUC1	9.6
Large intestine	SNUC2A	8
Large intestine	SNUC4	9.6
Large intestine	SNUC5	10.1
Large intestine	SW1116	9.1
Large intestine	SW1417	10.3
Large intestine	SW1463	10.1
Large intestine	SW403	10.4
Large intestine	SW480	9.9
Large intestine	SW48	9.7
Large intestine	SW620	9.8
Large intestine	SW837	10
Large intestine	SW948	9.8
Large intestine	T84	9.8
Liver	ALEXANDERCELLS	10.3
Liver	C3A	10.2
Liver	HEP3B217	11.2
Liver	HEPG2	10.1
Liver	HLE	10.5
Liver	HLF	9.7
Liver	HUH1	9.4
Liver	HUH6	10.4
Liver	HUH7	10.7
Liver	JHH1	9.8
Liver	JHH2	9
Liver	JHH4	10
Liver	JHH5	9.6
Liver	JHH6	10.4
Liver	JHH7	9.8
Liver	LI7	10.3
Liver	PLCPRF5	9.8
Liver	SKHEP1	9.4
Liver	SNU182	10
Liver	SNU387	8.9
Liver	SNU398	10.4
Liver	SNU423	9.2
Liver	SNU449	9.9
Liver	SNU475	9.7
Liver	SNU761	9
Liver	SNU878	9.3
Liver	SNU886	9.5
Lung	A549	9.5
Lung	ABC1	10.8
Lung	BEN	8.7
Lung	CAL12T	9.9
Lung	CALU1	9.3
Lung	CALU3	10.3
Lung	CALU6	9.4
Lung	CHAGOK1	10.3
Lung	COLO668	9.6
Lung	COLO699	9.7
Lung	CORL105	9.9
Lung	CORL23	9
Lung	CORL24	10.1
Lung	CORL279	10.1
Lung	CORL311	9.6
Lung	CORL47	9.9
Lung	CORL51	9.9
Lung	CORL88	11.2
Lung	CORL95	9.9
Lung	CPCN	10.4
Lung	DMS114	10.8
Lung	DMS153	10.6
Lung	DMS273	8.5
Lung	DMS454	10.1
Lung	DMS53	8.8
Lung	DMS79	11.4
Lung	DV90	10
Lung	EBC1	10.9
Lung	EPLC272H	9.9
Lung	HARA	10.6
Lung	HCC1171	10.3
Lung	HCC1195	10.1
Lung	HCC15	10
Lung	HCC2279	9.7
Lung	HCC2935	8.4
Lung	HCC33	10.8
Lung	HCC366	10.3
Lung	HCC4006	10.2
Lung	HCC44	8.3
Lung	HCC78	10.5
Lung	HCC827	9.2
Lung	HCC95	9.9
Lung	HLC1	9.1
Lung	HLFA	8.4
Lung	HS229T	9.9
Lung	HS618T	9.2
Lung	IALM	9.6
Lung	KNS62	8.8
Lung	LC1F	9.9
Lung	LC1SQSF	10.3
Lung	LCLC103H	8.9
Lung	LCLC97TM1	9.9
Lung	LK2	10.4
Lung	LOUNH91	8.5
Lung	LU65	9.7
Lung	LU99	11.2
Lung	LUDLU1	10.6
Lung	LXF289	9.6
Lung	MORCPR	10.5
Lung	NCIH1048	9.4
Lung	NCIH1092	10.5
Lung	NCIH1105	11.2
Lung	NCIH1155	11
Lung	NCIH1184	10.1
Lung	NCIH1299	10.6
Lung	NCIH1339	10.5
Lung	NCIH1341	10.8
Lung	NCIH1355	10.1
Lung	NCIH1373	10.1
Lung	NCIH1385	10
Lung	NCIH1395	8.6
Lung	NCIH1435	11.2
Lung	NCIH1436	10.6
Lung	NCIH1437	10.1
Lung	NCIH146	11
Lung	NCIH1563	9.3
Lung	NCIH1568	10.1
Lung	NCIH1573	8.8
Lung	NCIH1581	10.6
Lung	NCIH1618	11
Lung	NCIH1623	10
Lung	NCIH1648	10.2
Lung	NCIH1650	10.8
Lung	NCIH1651	9.9
Lung	NCIH1666	9.1
Lung	NCIH1693	10.2
Lung	NCIH1694	10.5
Lung	NCIH1703	10.7
Lung	NCIH1734	10.5
Lung	NCIH1755	10.3
Lung	NCIH1781	11.1
Lung	NCIH1792	8.7
Lung	NCIH1793	9.4
Lung	NCIH1836	10.4
Lung	NCIH1838	9.8
Lung	NCIH1869	10
Lung	NCIH1876	9.5
Lung	NCIH1915	9.6
Lung	NCIH1930	10.6
Lung	NCIH1944	10.8
Lung	NCIH1963	9.9
Lung	NCIH196	9.9
Lung	NCIH1975	9.1
Lung	NCIH2009	10.1
Lung	NCIH2023	10.3
Lung	NCIH2029	10.8
Lung	NCIH2030	10.1
Lung	NCIH2066	9.7
Lung	NCIH2081	9.7
Lung	NCIH2085	9.8
Lung	NCIH2087	11
Lung	NCIH209	10.4
Lung	NCIH2106	10.2
Lung	NCIH2110	9.1
Lung	NCIH211	11.6
Lung	NCIH2122	8.3
Lung	NCIH2126	8.7
Lung	NCIH2141	10.7
Lung	NCIH2170	9.6
Lung	NCIH2171	9.6
Lung	NCIH2172	10
Lung	NCIH2196	9.9
Lung	NCIH2227	9.1
Lung	NCIH2228	9.3
Lung	NCIH226	9.4
Lung	NCIH2286	10.1
Lung	NCIH2291	10.1
Lung	NCIH2342	11
Lung	NCIH2347	10.3
Lung	NCIH23	9.8
Lung	NCIH2405	9.7
Lung	NCIH2444	9.8
Lung	NCIH292	9.5
Lung	NCIH322	10.5
Lung	NCIH3255	10.3
Lung	NCIH358	10.7
Lung	NCIH441	10.4
Lung	NCIH446	10.4
Lung	NCIH460	9.6
Lung	NCIH510	9.6
Lung	NCIH520	10.3
Lung	NCIH522	9.7
Lung	NCIH524	9.8
Lung	NCIH526	10.1
Lung	NCIH596	9.4
Lung	NCIH647	9.9
Lung	NCIH650	9.5
Lung	NCIH661	10.4
Lung	NCIH69	10.9
Lung	NCIH727	10.4
Lung	NCIH810	9.8
Lung	NCIH82	10.1
Lung	NCIH838	10.8
Lung	NCIH841	9
Lung	NCIH854	9.3
Lung	NCIH889	9.4
Lung	PC14	9.3
Lung	RERFLCAD1	10.6
Lung	RERFLCAD2	10.1
Lung	RERFLCAI	10.4
Lung	RERFLCKJ	9.2
Lung	RERFLCMS	9.8
Lung	RERFLCSQ1	9.6
Lung	SBC5	9.6
Lung	SCLC21H	10.9
Lung	SHP77	10.2
Lung	SKLU1	10.1
Lung	SKMES1	8.1
Lung	SQ1	9.8
Lung	SW1271	9.2
Lung	SW1573	9.8
Lung	SW900	9.3
Lung	VMRCLCD	9.9
Lung	VMRCLCP	10
Oesophagus	COLO680N	9.5
Oesophagus	ECGI10	8.8
Oesophagus	KYSE140	10.5
Oesophagus	KYSE150	8.9
Oesophagus	KYSE180	10.5
Oesophagus	KYSE270	9.2
Oesophagus	KYSE30	8.1
Oesophagus	KYSE410	10.8
Oesophagus	KYSE450	9.3
Oesophagus	KYSE510	11.2
Oesophagus	KYSE520	9.6
Oesophagus	KYSE70	8.2
Oesophagus	OE19	10
Oesophagus	OE33	10.8
Oesophagus	TE10	11.1
Oesophagus	TE11	11
Oesophagus	TE14	9.8
Oesophagus	TE15	9.7
Oesophagus	TE1	9.9
Oesophagus	TE4	10.7
Oesophagus	TE5	9.4
Oesophagus	TE6	10.7
Oesophagus	TE8	12.5
Oesophagus	TE9	9.1
Oesophagus	TT	9.3
Ovary	59M	10.6
Ovary	A2780	10.2
Ovary	CAOV3	9.3
Ovary	CAOV4	8.4
Ovary	COLO704	11.1
Ovary	COV318	8.3
Ovary	COV362	11
Ovary	COV434	9.8
Ovary	COV504	9.7
Ovary	COV644	9.6
Ovary	EFO21	8.9
Ovary	EFO27	8.1
Ovary	ES2	10
Ovary	FUOV1	10.1
Ovary	HEYA8	10.4
Ovary	HS571T	7.5
Ovary	IGROV1	8.6
Ovary	JHOC5	10.1
Ovary	JHOM1	8.6
Ovary	JHOM2B	10.1
Ovary	JHOS2	10.3
Ovary	JHOS4	10.5
Ovary	KURAMOCHI	10.5
Ovary	MCAS	9.6
Ovary	NIHOVCAR3	9.5
Ovary	OAW28	10.1
Ovary	OAW42	9.9
Ovary	OC314	9.6
Ovary	OC316	9.8
Ovary	ONCODG1	9.5
Ovary	OV56	9.3
Ovary	OV7	9.2
Ovary	OV90	9.2
Ovary	OVCAR4	9.3
Ovary	OVCAR8	11.2
Ovary	OVISE	9.3
Ovary	OVK18	9.3
Ovary	OVKATE	10.4
Ovary	OVMANA	8.2
Ovary	OVSAHO	10.1
Ovary	OVTOKO	9.5
Ovary	RMGI	7.6
Ovary	RMUGS	9.4
Ovary	SKOV3	9.5
Ovary	SNU119	11.7
Ovary	SNU840	9.7
Ovary	SNU8	9.3
Ovary	TOV112D	10.1
Ovary	TOV21G	9.6
Ovary	TYKNU	9.8
Pancreas	ASPC1	8.2
Pancreas	BXPC3	9.4
Pancreas	CAPAN1	10.1
Pancreas	CAPAN2	10
Pancreas	CFPAC1	8.4
Pancreas	DANG	10.1
Pancreas	HPAC	10.3
Pancreas	HPAFII	8.9
Pancreas	HS766T	9.2
Pancreas	HUPT3	11.3
Pancreas	HUPT4	10.4
Pancreas	KCIMOH1	9.3
Pancreas	KLM1	9.7
Pancreas	KP2	9.8
Pancreas	KP3	9.2
Pancreas	KP4	10.6
Pancreas	L33	10.3
Pancreas	MIAPACA2	9.5
Pancreas	PANC0203	11.1
Pancreas	PANC0213	8.8
Pancreas	PANC0327	10.4
Pancreas	PANC0403	10
Pancreas	PANC0504	9.4
Pancreas	PANC0813	10.8
Pancreas	PANC1005	10.6
Pancreas	PANC1	9.8
Pancreas	PATU8902	10.7
Pancreas	PATU8988S	9.9
Pancreas	PATU8988T	10.3
Pancreas	PK1	10.1
Pancreas	PK45H	10.4
Pancreas	PK59	8.5
Pancreas	PL45	10.3
Pancreas	PSN1	9.4
Pancreas	QGP1	9.6
Pancreas	SNU213	9.9
Pancreas	SNU324	9.8
Pancreas	SNU410	9.5
Pancreas	SU8686	8
Pancreas	SUIT2	10.5
Pancreas	SW1990	10
Pancreas	T3M4	10.1
Pancreas	TCCPAN2	8.9
Pancreas	YAPC	10
Pleura	ACCMESO1	9.8
Pleura	DM3	7.5
Pleura	ISTMES1	10.6
Pleura	ISTMES2	8.9
Pleura	JL1	9
Pleura	MPP89	9.8
Pleura	MSTO211H	9.3
Pleura	NCIH2052	9.9
Pleura	NCIH2452	9.6
Pleura	NCIH28	9.3
Prostate	22RV1	10.9
Prostate	DU145	9.9
Prostate	LNCAPCLONEFGC	10.1
Prostate	MDAPCA2B	10.1
Prostate	NCIH660	11.6
Prostate	PC3	10.2
Prostate	VCAP	10.9
Salivary gland	A253	10.3
Salivary gland	YD15	10.7
Skin	A101D	9
Skin	A2058	9.9
Skin	A375	9.2
Skin	C32	10
Skin	CHL1	10.3
Skin	CJM	9.1
Skin	COLO679	9.3
Skin	COLO741	9
Skin	COLO783	8.8
Skin	COLO792	8.6
Skin	COLO800	9.1
Skin	COLO818	9.8
Skin	COLO829	8.3
Skin	COLO849	9.5
Skin	G361	9.9
Skin	GRM	9.3
Skin	HMCB	10.8
Skin	HS294T	7.7
Skin	HS600T	8.8
Skin	HS688AT	7.9
Skin	HS695T	9.5
Skin	HS839T	9.1
Skin	HS852T	9.3
Skin	HS895T	8.6
Skin	HS934T	9.2
Skin	HS936T	9.3
Skin	HS939T	9.5
Skin	HS940T	8.3
Skin	HS944T	9.3
Skin	HT144	9.6
Skin	IGR1	8.9
Skin	IGR37	9.7
Skin	IGR39	10.4
Skin	IPC298	9.6
Skin	K029AX	9.2
Skin	LOXIMVI	9.7
Skin	MALME3M	9
Skin	MDAMB435S	9.9
Skin	MELHO	9.3
Skin	MELJUSO	9.4
Skin	MEWO	9.6
Skin	RPMI7951	9.7
Skin	RVH421	9.5
Skin	SH4	9.9
Skin	SKMEL1	9.6
Skin	SKMEL24	8.7
Skin	SKMEL28	9.4
Skin	SKMEL2	9.5
Skin	SKMEL30	9.8
Skin	SKMEL31	9.2
Skin	SKMEL3	9.3
Skin	SKMEL5	9.3
Skin	UACC257	9.7
Skin	UACC62	8.7
Skin	WM115	8.5
Skin	WM1799	9.9
Skin	WM2664	8.8
Skin	WM793	9.6
Skin	WM88	8.6
Skin	WM983B	10.6
Small intestine	HUTU80	9.9
Soft tissue	A204	9.4
Soft tissue	G401	9.2
Soft tissue	G402	9.5
Soft tissue	GCT	10
Soft tissue	HS729	9.7
Soft tissue	HT1080	9.3
Soft tissue	KYM1	9.8
Soft tissue	MESSA	8.9
Soft tissue	RD	10.2
Soft tissue	RH30	8.4
Soft tissue	RH41	9.9
Soft tissue	RKN	9.2
Soft tissue	S117	9.4
Soft tissue	SJRH30	9.2
Soft tissue	SKLMS1	9.1
Soft tissue	SKUT1	10.4
Soft tissue	TE125T	8.9
Soft tissue	TE159T	8.3
Soft tissue	TE441T	10.5
Soft tissue	TE617T	9.9
Stomach	2313287	10.3
Stomach	AGS	9.5
Stomach	AZ521	10.1
Stomach	ECC10	11
Stomach	ECC12	10.8
Stomach	FU97	9.9
Stomach	GCIY	9.7
Stomach	GSS	9.8
Stomach	GSU	8.9
Stomach	HGC27	12.8
Stomach	HS746T	10.2
Stomach	HUG1N	10.7
Stomach	IM95	9.7
Stomach	KATOIII	10.2
Stomach	KE39	10.8
Stomach	LMSU	11.7
Stomach	MKN1	9.9
Stomach	MKN45	10
Stomach	MKN74	11
Stomach	MKN7	10.7
Stomach	NCCSTCK140	8.7
Stomach	NCIN87	10.1
Stomach	NUGC2	8.4
Stomach	NUGC3	9.8
Stomach	NUGC4	8.4
Stomach	OCUM1	9.3
Stomach	RERFGC1B	9.8
Stomach	SH10TC	10.2
Stomach	SNU16	10
Stomach	SNU1	10.8
Stomach	SNU216	9.9
Stomach	SNU520	9
Stomach	SNU5	9.8
Stomach	SNU601	10.1
Stomach	SNU620	10.1
Stomach	SNU668	9.8
Stomach	SNU719	8.8
Stomach	TGBC11TKB	9.7
Thyroid	8305C	9.3
Thyroid	8505C	10.3
Thyroid	BCPAP	6.4
Thyroid	BHT101	9
Thyroid	CAL62	10.6
Thyroid	CGTHW1	9.6
Thyroid	FTC133	9.1
Thyroid	FTC238	10.7
Thyroid	ML1	9.5
Thyroid	SW579	9.4
Thyroid	TT2609C02	9.9
Thyroid	TT	10.1
Upper aerodigestive tract	BHY	9.4
Upper aerodigestive tract	BICR16	9.3
Upper aerodigestive tract	BICR18	9.8
Upper aerodigestive tract	BICR22	9.1
Upper aerodigestive tract	BICR31	9.3
Upper aerodigestive tract	BICR56	8
Upper aerodigestive tract	BICR6	9.1
Upper aerodigestive tract	CAL27	9.1
Upper aerodigestive tract	CAL33	9.8
Upper aerodigestive tract	DETROIT562	10.8
Upper aerodigestive tract	FADU	10.7
Upper aerodigestive tract	HS840T	9.1
Upper aerodigestive tract	HSC2	8.4
Upper aerodigestive tract	HSC3	10.3
Upper aerodigestive tract	HSC4	9.1
Upper aerodigestive tract	PECAPJ15	9.6
Upper aerodigestive tract	PECAPJ34CLONEC12	9.9
Upper aerodigestive tract	PECAPJ41CLONED2	9.4
Upper aerodigestive tract	PECAPJ49	9.6
Upper aerodigestive tract	SCC15	9.1
Upper aerodigestive tract	SCC25	9.7
Upper aerodigestive tract	SCC4	9.3
Upper aerodigestive tract	SCC9	9.5
Upper aerodigestive tract	SNU1076	8.4
Upper aerodigestive tract	SNU1214	10.2
Upper aerodigestive tract	SNU46	9.9
Upper aerodigestive tract	SNU899	8.9
Upper aerodigestive tract	YD10B	9.7
Upper aerodigestive tract	YD38	10.1
Upper aerodigestive tract	YD8	8.2
Urinary tract	5637	9.1
Urinary tract	639V	10.4
Urinary tract	647V	10.1
Urinary tract	BC3C	10.4
Urinary tract	BFTC905	9.2
Urinary tract	CAL29	10
Urinary tract	HS172T	8.8
Urinary tract	HT1197	8.6
Urinary tract	HT1376	9.7
Urinary tract	J82	9.8
Urinary tract	JMSU1	10.1
Urinary tract	KMBC2	9
Urinary tract	KU1919	10.4
Urinary tract	RT11284	10.1
Urinary tract	RT112	9.9
Urinary tract	RT4	9.8
Urinary tract	SCABER	9.9
Urinary tract	SW1710	9.8
Urinary tract	SW780	9.7
Urinary tract	T24	9.7
Urinary tract	TCCSUP	9.2
Urinary tract	UMUC1	8.7
Urinary tract	UMUC3	11.2
Urinary tract	VMCUB1	10.4

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	3.2
Adrenal gland	4.5
Appendix	10.5
Bone marrow	15.9
Breast	8.2
Cerebral cortex	4.8
Cervix, uterine	18.4
Colon	5.2
Duodenum	5.1
Endometrium	7.1
Epididymis	4.5
Esophagus	6.2
Fallopian tube	4.5
Gallbladder	5.1
Heart muscle	3.9
Kidney	1.5
Liver	4.9
Lung	5.2
Lymph node	16.7
Ovary	8.5
Pancreas	0.6
Parathyroid gland	4.8
Placenta	6.7
Prostate	16.5
Rectum	7.6
Salivary gland	1.3
Seminal vesicle	6.4
Skeletal muscle	0.2
Skin	8.1
Small intestine	5.9
Smooth muscle	5.8
Spleen	6.8
Stomach	4.2
Testis	34.3
Thyroid gland	6.3
Tonsil	11.9
Urinary bladder	7.1

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27895739	underexpression	Breast Carcinoma	The expression of TSPYL5, MTDH and ATAD2 was significantly decreased in the metastatic (P=0.002, P=0.018 and P=0.016, respectively) and non-metastatic (P=0.038, P=0.045 and P=0.000, respectively) breast cancer groups compared with the control.
27565322	Overexpression	Colorectal Carcinoma	ATPase family AAA domain-containing protein 2 (ATAD2), a member of ATPase family, is highly expressed in various cancers, including colorectal cancer. Our results suggest that silencing of ATAD2 inhibits migration and invasion of colorectal cancer cells by suppressing EMT and decreasing the activity of MMPs.
27239961	Overexpression	Hepatocellular Carcinoma	In the present study, we found that ANCCA/PRO2000 overexpression in HCC specimens correlated with aggressive tumor behavior and poor survival.
27131099	Overexpression	Squamous Cell Lung Carcinoma	ANCCA mRNA and protein expression are increased in SCLC tissues and cell lines.
26819280	Overexpression	Colorectal Carcinoma	ATAD2 overexpression is associated with progression and prognosis in colorectal cancer.
26697062	Overexpression	Colorectal Carcinoma	The results showed that high expression of ATAD2 was significantly correlated with tumor size (P < 0.001), serum CEA (P = 0.012), lymph node metastasis (P = 0.018), liver metastasis (P = 0.025), and clinical stage (P = 0.004).
26527032	Overexpression	Gastric Carcinoma	In our results, ATAD2 mRNA and protein were highly expressed in gastric cancer samples. ATAD2 overexpression was correlated with advanced clinical stage, tumor depth, lymph node metastasis, and distant metastasis.
26497681	Overexpression	Hepatocellular Carcinoma	We demonstrated that ATAD2 was over-expressed in HCC patients, where high ATAD2 levels were significantly correlated with aggressive phenotypes such as high AFP levels, advanced tumor stages, and vascular invasion.
26308378	Overexpression	Endometrial Carcinoma	ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma.
25934333	Overexpression	Endometrial Carcinoma	Overexpression of ANCCA/ATAD2 in endometrial carcinoma and its correlation with tumor progression and poor prognosis.
25813398	Overexpression	Cervical Carcinoma	ATAD2 was shown to be highly expressed in cervical cancer tissues, both at the transcriptional and protein levels, and was correlated with poor patient survival (P<0.05).
24805933	Overexpression	Hepatocellular Carcinoma	We found that ATAD2 is highly expressed in HCC tissues, compared with adjacent normal tissues, and patients with high expression of ATAD2 had a poorer prognosis.
24761900	Overexpression	Ovarian Carcinoma	ATAD2 was shown to be highly expressed in 65.5% (72/110) of ovarian cancer cases, both at transcriptional and protein levels.
24708861	Overexpression	Hepatocellular Carcinoma	PRO2000/ANCCA expression was associated with clinicopathological features such as histological differentiation, number of tumor nodules, TNM stage, tumor microsatellite, portal vein tumor thrombus and recurrence, but not with gender, age, tumor size, cirrhosis, HBV infection and serum fetoprotein (AFP) level.
24552534	Overexpression	Hepatocellular Carcinoma	ATAD2 was highly expressed in liver cancer samples and correlated with poor survival.
24489661	Overexpression (Copy number gain)	Breast Carcinoma	Frequently amplified and overexpressed genes included ATAD2, BRAF, DERL1, DNMTRB and NEK2A.
23784380	Overexpression (Copy number gain)	Breast Carcinoma	Genomic studies of FC-IBC02 and other IBC cell lines showed that IBC cells had important amplification of 8q24 where MYC, ATAD2 and the focal adhesion kinase FAK1 are located.
23393560	Overexpression (Copy number gain)	Endometrial Carcinoma	Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers.
23038103	Overexpression	Prostate Carcinoma	EZH2 and ANCCA are androgen regulated and strongly expressed in early prostate morphogenesis and during puberty, suggesting their important role in prostate development.
23033341	Overexpression (Copy number gain)	Lung Carcinoma	A number of epigenetic regulators, including KDM6A, ASH1L, SMARCA4, and ATAD2, are frequently altered by mutations or copy number changes.
20864510	Overexpression	Breast Carcinoma	ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.
19843847	Overexpression (Copy number gain)	Breast Carcinoma	Consistent with this, we show that ATAD2 expression is high in several human tumors and that the expression levels correlate with clinical outcome of breast cancer patients.

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.505	1.68e-27	5	34.7	60.4	Gain
BRCA	Breast invasive carcinoma	1075	0.624	3.61e-117	3	35.7	61.3	Gain
CESC	Cervical and endocervical cancers	292	0.53	1.6e-22	7.2	53.4	39.4	Gain
COAD	Colon adenocarcinoma	449	0.481	2.54e-27	2	41.4	56.6	Gain
ESCA	Esophageal carcinoma	183	0.542	2.44e-15	4.4	22.4	73.2	Gain
GBM	Glioblastoma multiforme	147	0.425	7.88e-08	8.8	77.6	13.6	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.318	1.59e-13	0.8	26.1	73.2	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.255	3.22e-09	9.5	76	14.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.195	0.000876	3.1	87.5	9.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.349	4.08e-06	0	88	12	Neutral
LGG	Brain Lower Grade Glioma	513	0.322	7.55e-14	1.9	78.4	19.7	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.422	4.01e-17	4.9	33.2	61.8	Gain
LUAD	Lung adenocarcinoma	512	0.484	1.73e-31	5.5	35.4	59.2	Gain
LUSC	Lung squamous cell carcinoma	498	0.571	1.86e-44	4.8	27.7	67.5	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.624	9.98e-34	5	17	78	Gain
PAAD	Pancreatic adenocarcinoma	177	0.553	1.5e-15	4	58.8	37.3	Gain
PCPG	Pheochromocytoma and Paraganglioma	162	0.13	0.0986	8	83.3	8.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.534	1.52e-37	1	68.4	30.5	Neutral
READ	Rectum adenocarcinoma	164	0.383	4.19e-07	3	31.7	65.2	Gain
SARC	Sarcoma	255	0.327	9.37e-08	17.3	51.8	31	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.369	2.84e-13	6	42	52	Gain
STAD	Stomach adenocarcinoma	413	0.581	1.07e-38	2.7	30.5	66.8	Gain
TGCT	Testicular Germ Cell Tumors	150	0.391	7.53e-07	4.7	24.7	70.7	Gain
THCA	Thyroid carcinoma	497	0.133	0.00297	1	97.6	1.4	Neutral
THYM	Thymoma	119	0.186	0.0432	1.7	89.1	9.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.486	3.21e-33	3	61.3	35.8	Gain

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.216	7.76e-06	17	408	0	0.546	NS/NA
BRCA	Breast invasive carcinoma	-0.393	0	83	785	-0.001	0.114	NS/NA
CESC	Cervical and endocervical cancers	-0.26	3.77e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.253	5.84e-06	19	297	-0.001	0.518	NS/NA
ESCA	Esophageal carcinoma	-0.34	1.44e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.19	0.129	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.185	1.49e-05	20	522	-0.116	0.000623	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.108	0.046	24	319	0.004	0.286	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.114	0.0488	23	275	-0.001	0.912	NS/NA
LAML	Acute Myeloid Leukemia	-0.21	0.00615	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.1	0.0218	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.318	4.28e-11	41	373	-0.002	0.201	NS/NA
LUAD	Lung adenocarcinoma	-0.073	0.11	21	456	-0.001	0.87	NS/NA
LUSC	Lung squamous cell carcinoma	-0.112	0.029	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.817	0.0108	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.159	0.0315	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.201	0.00588	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.218	3.97e-07	35	498	0	0.0142	NS/NA
READ	Rectum adenocarcinoma	-0.101	0.317	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.235	0.000123	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.249	4.96e-08	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.267	1.85e-07	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.158	0.0491	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.085	0.0457	50	509	-0.001	0.0692	NS/NA
THYM	Thymoma	-0.117	0.2	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.233	4.05e-07	34	431	-0.003	0.00431	NS/NA

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	3	High
Breast	1	Low
Bronchus	2	Medium
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	0	Not detected
Lung	0	Not detected
Lymph node	2	Medium
Nasopharynx	0	Not detected
Oral mucosa	3	High
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	1	Low
Placenta	1	Low
Prostate	0	Not detected
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	1	Low
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	3	High
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	2	Medium
Stomach	2	Medium
Testis	3	High
Thyroid gland	0	Not detected
Tonsil	3	High
Urinary bladder	1	Low
Vagina	2	Medium

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.052	NS	24476821
BRCA	Breast invasive carcinoma	521	5.94e-36	Significant	23000897
COAD	Colon adenocarcinoma	149	0.468	NS	22810696
GBM	Glioblastoma multiforme	157	0.000611	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00864	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.000539	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.000122	Significant	26824661
LUAD	Lung adenocarcinoma	230	3.19e-16	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0501	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0176	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00347	Significant	26544944
READ	Rectum adenocarcinoma	67	0.346	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.426	NS	26091043
STAD	Stomach adenocarcinoma	277	2.12e-13	Significant	25079317
THCA	Thyroid carcinoma	391	2.11e-15	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.89e-14	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.99	0.964	NS
BRCA	Breast invasive carcinoma	1079	1.137	0.588	NS
CESC	Cervical and endocervical cancers	291	0.736	0.39	NS
COAD	Colon adenocarcinoma	439	0.823	0.522	NS
ESCA	Esophageal carcinoma	184	1.201	0.578	NS
GBM	Glioblastoma multiforme	158	1.099	0.725	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.938	0.754	NS
KIRC	Kidney renal clear cell carcinoma	531	1.803	0.00458	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	6.126	8.5e-06	Shorter
LAML	Acute Myeloid Leukemia	149	1.245	0.446	NS
LGG	Brain Lower Grade Glioma	511	2.976	1.53e-05	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.109	0.695	NS
LUAD	Lung adenocarcinoma	502	1.878	0.00398	Shorter
LUSC	Lung squamous cell carcinoma	494	0.833	0.335	NS
OV	Ovarian serous cystadenocarcinoma	303	1.234	0.298	NS
PAAD	Pancreatic adenocarcinoma	177	2.166	0.0156	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	3.843	0.197	NS
PRAD	Prostate adenocarcinoma	497	1.724	0.554	NS
READ	Rectum adenocarcinoma	159	1.043	0.937	NS
SARC	Sarcoma	259	1.491	0.187	NS
SKCM	Skin Cutaneous Melanoma	459	1.047	0.812	NS
STAD	Stomach adenocarcinoma	388	0.67	0.0775	NS
TGCT	Testicular Germ Cell Tumors	134	0.544	0.614	NS
THCA	Thyroid carcinoma	500	0.587	0.484	NS
THYM	Thymoma	119	0	0.0726	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	4.153	4.65e-05	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.044	0.376	NS
BRCA	Breast invasive carcinoma	1071	0.041	0.176	NS
CESC	Cervical and endocervical cancers	167	0.03	0.705	NS
COAD	Colon adenocarcinoma	445	0.014	0.769	NS
ESCA	Esophageal carcinoma	162	-0.026	0.741	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.012	0.802	NS
KIRC	Kidney renal clear cell carcinoma	531	0.224	1.88e-07	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.438	1.22e-13	Higher
LIHC	Liver hepatocellular carcinoma	347	-0.017	0.751	NS
LUAD	Lung adenocarcinoma	507	0.144	0.00114	Higher
LUSC	Lung squamous cell carcinoma	497	0.152	0.000679	Higher
OV	Ovarian serous cystadenocarcinoma	302	-0.008	0.888	NS
PAAD	Pancreatic adenocarcinoma	176	-0.041	0.585	NS
READ	Rectum adenocarcinoma	156	0.107	0.184	NS
SKCM	Skin Cutaneous Melanoma	410	-0.025	0.609	NS
STAD	Stomach adenocarcinoma	392	-0.04	0.429	NS
TGCT	Testicular Germ Cell Tumors	81	-0.31	0.00482	Lower
THCA	Thyroid carcinoma	499	0.026	0.564	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.194	1.25e-05	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.012	0.841	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.216	1.08e-06	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.182	2.69e-05	Higher
LGG	Brain Lower Grade Glioma	514	0.303	2.2e-12	Higher
LIHC	Liver hepatocellular carcinoma	366	0.285	3.01e-08	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.122	0.0362	Higher
PAAD	Pancreatic adenocarcinoma	176	0.161	0.0331	Higher
STAD	Stomach adenocarcinoma	406	-0.178	0.000314	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.513	3.68e-37	Higher

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for ATAD2.

Summary
Symbol	ATAD2
Name	ATPase family, AAA domain containing 2
Aliases	PRO2000; DKFZp667N1320; MGC5254; MGC29843; CT137; ANCCA; AAA nuclear coregulator cancer-associated protein; ......
Location	8q24.13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27239961	Hepatocellular Carcinoma	upstream	miR-372	negative regulation	Additional research identified that miR-372, as a prognostic factor for HCC, could directly target ANCCA/PRO2000.
27239961	Hepatocellular Carcinoma	downstream	miR-520a	negative regulation	Mechanistically, ANCCA/PRO2000 not only interacts with E2F2 but also negatively regulates miR-520a that inhibits E2F2 to cooperatively promote in vitro and in vivo growth of HCC cells.
26497681	Hepatocellular Carcinoma	partner	MKK3/6	interaction	In HCC cells, we demonstrated that ATAD2 directly interacted with MKK3/6, which prevented p38 activation and therefore inhibited p38-mediated apoptosis.
26497681	Hepatocellular Carcinoma	downstream	p53/p38	negative regulation	Suppression of ATAD2 inhibits hepatocellular carcinoma progression through activation of p53- and p38-mediated apoptotic signaling.
26308378	Endometrial Carcinoma	downstream	B-MYB; CDCs; E2Fs		Gene expression alterations in samples with high ATAD2 expression revealed upregulation of several cancer-related genes (B-MYB, CDCs, E2Fs) and gene sets that previously have been linked to aggressive disease and potential for new targeting therapies.
24805933	Hepatocellular Carcinoma	partner	MYC	cooperation	We speculate that ATAD2 cooperates with the MYC gene to regulate the expression of SMO and Gli, activating the Hh pathway and inducing an active feedback of the Hh pathway.
24805933	Hepatocellular Carcinoma	downstream	SMO; Gli	Regulation	We speculate that ATAD2 cooperates with the MYC gene to regulate the expression of SMO and Gli, activating the Hh pathway and inducing an active feedback of the Hh pathway.
24552534	Hepatocellular Carcinoma	upstream	miR-372	negative regulation	The findings demonstrated that miR-372 suppressed the expression of ATAD2, which was highly expressed in HCC and exerted a proto-oncogene effect in hepatic carcinogenesis.
24552534	Hepatocellular Carcinoma	downstream	APC; CTNNA1	Negatively regulation; Positively regulation	In addition, ATAD2 knockdown was found to extremely up-regulate APC expression and down-regulate CTNNA1 at the mRNA level.
20864510	Breast Carcinoma	downstream	B-Myb; EZH2	Regulation	ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.
19843847	Breast Carcinoma	partner	MYC	binding	We show that ATAD2 binds the MYC oncogene and stimulates its transcriptional activity.