CR2Cancer

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF05301 GNAT acetyltransferase

Function

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0000226 microtubule cytoskeleton organization GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0007283 spermatogenesis GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0021537 telencephalon development GO:0021542 dentate gyrus development GO:0021543 pallium development GO:0021761 limbic system development GO:0021766 hippocampus development GO:0030900 forebrain development GO:0031334 positive regulation of protein complex assembly GO:0032886 regulation of microtubule-based process GO:0043254 regulation of protein complex assembly GO:0043543 protein acylation GO:0044089 positive regulation of cellular component biogenesis GO:0044546 NLRP3 inflammasome complex assembly GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0048232 male gamete generation GO:0051493 regulation of cytoskeleton organization GO:0070507 regulation of microtubule cytoskeleton organization GO:0071929 alpha-tubulin acetylation GO:1900225 regulation of NLRP3 inflammasome complex assembly GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
Molecular Function	GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0008080 N-acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0019799 tubulin N-acetyltransferase activity GO:0034212 peptide N-acetyltransferase activity GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component	GO:0005819 spindle GO:0005874 microtubule GO:0005905 clathrin-coated pit GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0030424 axon GO:0072686 mitotic spindle GO:0097427 microtubule bundle GO:0098589 membrane region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5617833: Cilium Assembly R-HSA-1852241: Organelle biogenesis and maintenance

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM73762	c.742G>C	p.E248Q	Substitution - Missense	Ovary
COSM741467	c.910G>A	p.A304T	Substitution - Missense	Lung
COSM4663952	c.260+2delT	p.?	Unknown	Large_intestine
COSM1443055	c.894delC	p.P300fs*>24	Deletion - Frameshift	Large_intestine
COSM4590489	c.794A>C	p.H265P	Substitution - Missense	Upper_aerodigestive_tract
COSM265395	c.936_937insG	p.S315fs*>10	Insertion - Frameshift	Large_intestine
COSM3769980	c.682G>A	p.A228T	Substitution - Missense	Soft_tissue
COSM5710026	c.77C>G	p.A26G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM82041	c.669G>A	p.L223L	Substitution - coding silent	Ovary
COSM5510138	c.409C>T	p.R137*	Substitution - Nonsense	Biliary_tract
COSM5910506	c.261-7C>T	p.?	Unknown	Skin
COSM4509157	c.799C>T	p.P267S	Substitution - Missense	Skin
COSM5445094	c.603G>A	p.L201L	Substitution - coding silent	Oesophagus
COSM1443055	c.894delC	p.P300fs*>24	Deletion - Frameshift	Large_intestine
COSM3861461	c.453G>A	p.P151P	Substitution - coding silent	Stomach
COSM1443049	c.2T>G	p.M1R	Substitution - Missense	Large_intestine
COSM3251535	c.507G>A	p.K169K	Substitution - coding silent	Large_intestine
COSM4590489	c.794A>C	p.H265P	Substitution - Missense	Upper_aerodigestive_tract
COSM237015	c.436-4G>A	p.?	Unknown	Prostate
COSM1443055	c.894delC	p.P300fs*>24	Deletion - Frameshift	Large_intestine
COSM4885923	c.15C>A	p.F5L	Substitution - Missense	Upper_aerodigestive_tract
COSM5065509	c.798_799insC	p.R269fs*43	Insertion - Frameshift	Large_intestine
COSM3861464	c.584G>A	p.R195Q	Substitution - Missense	Stomach
COSM5017033	c.871C>G	p.L291V	Substitution - Missense	Kidney
COSM5910503	c.719G>A	p.R240Q	Substitution - Missense	Skin
COSM1077368	c.715G>A	p.D239N	Substitution - Missense	Endometrium
COSM5001462	c.789_790insG	p.A264fs*48	Insertion - Frameshift	Pancreas
COSM360158	c.80G>C	p.R27P	Substitution - Missense	Lung
COSM5946510	c.300A>C	p.G100G	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5810655	c.900A>C	p.P300P	Substitution - coding silent	Liver
COSM3861467	c.958C>T	p.R320C	Substitution - Missense	Stomach
COSM5065509	c.798_799insC	p.R269fs*43	Insertion - Frameshift	Large_intestine
COSM1246897	c.135C>T	p.T45T	Substitution - coding silent	Oesophagus
COSM1077369	c.725-1G>T	p.?	Unknown	Endometrium
COSM4572729	c.845T>A	p.L282H	Substitution - Missense	Skin
COSM4006289	c.169-6C>T	p.?	Unknown	Urinary_tract
COSM4836089	c.66G>C	p.L22L	Substitution - coding silent	Cervix
COSM5038326	c.798A>C	p.P266P	Substitution - coding silent	Skin
COSM252395	c.847C>T	p.R283C	Substitution - Missense	Ovary
COSM127503	c.414A>G	p.E138E	Substitution - coding silent	Upper_aerodigestive_tract
COSM3251541	c.772C>T	p.R258C	Substitution - Missense	Skin
COSM4751994	c.584-1G>T	p.?	Unknown	Stomach
COSM4663955	c.799delC	p.R269fs*>55	Deletion - Frameshift	Large_intestine
COSM3861461	c.453G>A	p.P151P	Substitution - coding silent	Prostate
COSM1443053	c.777C>T	p.R259R	Substitution - coding silent	Large_intestine
COSM4541950	c.309G>A	p.K103K	Substitution - coding silent	Skin
COSM5960577	c.718C>T	p.R240*	Substitution - Nonsense	Breast
COSM4590489	c.794A>C	p.H265P	Substitution - Missense	Upper_aerodigestive_tract

> Text Mining based Variations [ TOP ]
There is no record for ATAT1.

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q5SQI0	146	K	N6-acetyllysine	autocatalysis	No	None detected
Q5SQI0	233	K	N6-acetyllysine	autocatalysis	No	None detected
Q5SQI0	244	K	N6-acetyllysine	autocatalysis	No	None detected
Q5SQI0	272	S	Phosphoserine	-	No	None detected
Q5SQI0	276	S	Phosphoserine	-	No	None detected
Q5SQI0	305	R	Asymmetric dimethylarginine	-	No	None detected
Q5SQI0	315	S	Phosphoserine	-	No	None detected
Q5SQI0	323	R	Omega-N-methylarginine	-	No	None detected

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.174	3.98	0.89	3.58e-05	Over
BRCA	Breast invasive carcinoma	112	1100	3.454	3.742	0.425	7.64e-10	NS
CESC	Cervical and endocervical cancers	3	306	3.301	3.559	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	2.753	3.652	0.963	3.9e-20	Over
ESCA	Esophageal carcinoma	11	185	3.028	3.624	0.66	0.0053	Over
GBM	Glioblastoma multiforme	5	166	5.824	5.925	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	2.279	2.392	0.149	0.194	NS
KIRC	Kidney renal clear cell carcinoma	72	534	2.707	2.839	0.13	0.119	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	2.963	3.578	0.588	3.97e-05	Over
LAML	Acute Myeloid Leukemia	0	173	NA	4.515	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.713	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	1.225	2.387	1.07	3.47e-15	Over
LUAD	Lung adenocarcinoma	59	517	2.371	3.542	1.197	5.75e-29	Over
LUSC	Lung squamous cell carcinoma	51	501	2.472	3.361	0.832	3.2e-13	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.599	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.191	3.414	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	2.958	3.863	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.383	4.165	0.719	8.15e-18	Over
READ	Rectum adenocarcinoma	10	167	2.5	3.891	1.255	1.43e-09	Over
SARC	Sarcoma	2	263	3.034	3.314	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.422	3.847	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	3.116	3.783	0.701	6e-09	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	3.731	NA	NA	NA
THCA	Thyroid carcinoma	59	509	3.062	3.227	0.088	0.225	NS
THYM	Thymoma	2	120	3.622	3.665	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	3.714	4.497	0.804	6.29e-16	Over

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	0.7
Adrenal gland	0.4
Appendix	1
Bone marrow	0.3
Breast	0.5
Cerebral cortex	3.4
Cervix, uterine	1
Colon	0.6
Duodenum	0.5
Endometrium	2.7
Epididymis	4.3
Esophagus	0.2
Fallopian tube	2
Gallbladder	1.1
Heart muscle	0.2
Kidney	0.5
Liver	0.2
Lung	0.6
Lymph node	0.7
Ovary	1.9
Pancreas	0.1
Parathyroid gland	0.7
Placenta	0.7
Prostate	2.4
Rectum	0.7
Salivary gland	0.3
Seminal vesicle	0.5
Skeletal muscle	0.2
Skin	1.2
Small intestine	1
Smooth muscle	0.8
Spleen	0.7
Stomach	1.1
Testis	1.8
Thyroid gland	0.8
Tonsil	0.7
Urinary bladder	0.5

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
27836544	overexpression	Colon Carcinoma	Public transcriptome analysis showed that expression of ATAT1 is specifically upregulated in colon cancer tissue.
24096005	Overexpression	Pancreatic Carcinoma	The microtubule regulator DCLK1 marked a morphologically distinct and functionally unique population of pancreatic cancer-initiating cells. Cells that expressed DCLK1 also expressed high levels of ATAT1, HES1, HEY1, IGF1R, and ABL1, and manipulation of these pathways in PDAC cell lines inhibited their clonogenic potential.

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.294	1.63e-09	18.1	54	28	Neutral
BRCA	Breast invasive carcinoma	1075	0.493	6.8e-67	13.7	60.9	25.4	Neutral
CESC	Cervical and endocervical cancers	292	0.521	1.06e-21	12	60.6	27.4	Neutral
COAD	Colon adenocarcinoma	449	0.384	3.1e-17	9.6	69.5	20.9	Neutral
ESCA	Esophageal carcinoma	183	0.493	1.27e-12	20.8	50.3	29	Neutral
GBM	Glioblastoma multiforme	147	0.338	2.77e-05	19.7	76.2	4.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.381	3.37e-19	15.4	66.3	18.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.299	2.73e-12	18.5	79.6	1.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.458	2.5e-16	9.7	88.9	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.011	0.89	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.31	6.37e-13	5.8	92.2	1.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.34	2.6e-11	2.5	56.6	40.9	Gain
LUAD	Lung adenocarcinoma	512	0.435	4.97e-25	11.5	50.8	37.7	Gain
LUSC	Lung squamous cell carcinoma	498	0.424	3.99e-23	23.7	50.8	25.5	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.6	1.08e-30	17.7	33.3	49	Gain
PAAD	Pancreatic adenocarcinoma	177	0.331	6.57e-06	31.6	62.1	6.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.175	0.0257	1.2	90.1	8.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.13	0.00387	4.7	91.2	4.1	Neutral
READ	Rectum adenocarcinoma	164	0.332	1.41e-05	9.8	62.2	28	Neutral
SARC	Sarcoma	255	0.426	1.23e-12	25.9	52.5	21.6	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.519	9.7e-27	7.6	40.9	51.5	Gain
STAD	Stomach adenocarcinoma	413	0.487	5.83e-26	11.9	63.7	24.5	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.324	5.21e-05	10	72	18	Neutral
THCA	Thyroid carcinoma	497	0.1	0.026	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.521	1.2e-09	16.8	83.2	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.406	9.44e-23	2.8	79.1	18.1	Neutral

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.605	0	17	408	-0.142	2.14e-07	NS/NA
BRCA	Breast invasive carcinoma	-0.299	2.55e-19	83	785	0.004	0.221	NS/NA
CESC	Cervical and endocervical cancers	-0.35	3.08e-10	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.528	0	19	297	-0.087	0.0059	NS/NA
ESCA	Esophageal carcinoma	-0.42	1.52e-09	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.592	3.77e-07	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.29	7.3e-12	20	522	-0.003	0.564	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.153	0.00456	24	319	-0.02	5.76e-08	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.312	4.43e-08	23	275	-0.004	0.245	NS/NA
LAML	Acute Myeloid Leukemia	-0.08	0.301	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.645	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.506	0	41	373	-0.166	1.27e-28	NS/NA
LUAD	Lung adenocarcinoma	-0.368	5.67e-17	21	456	-0.031	0.0255	NS/NA
LUSC	Lung squamous cell carcinoma	-0.296	5.3e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.617	0.0857	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.334	4.3e-06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.306	2.28e-05	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.433	0	35	498	-0.078	2.52e-05	NS/NA
READ	Rectum adenocarcinoma	-0.536	1.26e-08	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.4	2.2e-11	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.464	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.427	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.2	0.0124	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.384	0	50	509	0.001	0.00023	NS/NA
THYM	Thymoma	-0.328	0.000249	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.382	0	34	431	-0.131	6.76e-11	NS/NA

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	1	Low
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	3	High
Kidney	2	Medium
Liver	2	Medium
Lung	2	Medium
Lymph node	1	Low
Nasopharynx	1	Low
Oral mucosa	1	Low
Ovary	1	Low
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	2	Medium
Rectum	1	Low
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	1	Low
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.077	NS	24476821
BRCA	Breast invasive carcinoma	521	9.86e-14	Significant	23000897
COAD	Colon adenocarcinoma	149	4.24e-09	Significant	22810696
GBM	Glioblastoma multiforme	157	2.91e-12	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000232	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.000143	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.1e-41	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00226	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	3.95e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.05e-05	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.216	NS	26544944
READ	Rectum adenocarcinoma	67	0.143	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.12	NS	26091043
STAD	Stomach adenocarcinoma	277	1.56e-05	Significant	25079317
THCA	Thyroid carcinoma	391	0.015	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.527	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.503	0.00187	Longer
BRCA	Breast invasive carcinoma	1079	1.024	0.92	NS
CESC	Cervical and endocervical cancers	291	0.879	0.695	NS
COAD	Colon adenocarcinoma	439	1.729	0.0768	NS
ESCA	Esophageal carcinoma	184	0.834	0.613	NS
GBM	Glioblastoma multiforme	158	0.741	0.234	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.799	0.24	NS
KIRC	Kidney renal clear cell carcinoma	531	3.005	3.58e-07	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.031	0.942	NS
LAML	Acute Myeloid Leukemia	149	0.774	0.387	NS
LGG	Brain Lower Grade Glioma	511	0.202	3.64e-10	Longer
LIHC	Liver hepatocellular carcinoma	365	1.613	0.0552	NS
LUAD	Lung adenocarcinoma	502	0.609	0.0158	Longer
LUSC	Lung squamous cell carcinoma	494	0.957	0.819	NS
OV	Ovarian serous cystadenocarcinoma	303	0.779	0.222	NS
PAAD	Pancreatic adenocarcinoma	177	0.348	0.000571	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.373	NS
PRAD	Prostate adenocarcinoma	497	528705843.262	0.0638	NS
READ	Rectum adenocarcinoma	159	0.221	0.0167	Longer
SARC	Sarcoma	259	2.314	0.00302	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.074	0.706	NS
STAD	Stomach adenocarcinoma	388	0.758	0.225	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.161	NS
THCA	Thyroid carcinoma	500	1.324	0.657	NS
THYM	Thymoma	119	0.169	0.0657	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.333	0.299	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.16	0.00118	Lower
BRCA	Breast invasive carcinoma	1071	0.029	0.349	NS
CESC	Cervical and endocervical cancers	167	0.069	0.379	NS
COAD	Colon adenocarcinoma	445	0.13	0.00584	Higher
ESCA	Esophageal carcinoma	162	-0.04	0.611	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.113	0.017	Higher
KIRC	Kidney renal clear cell carcinoma	531	0.084	0.054	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.15	0.0157	Lower
LIHC	Liver hepatocellular carcinoma	347	0.186	0.000496	Higher
LUAD	Lung adenocarcinoma	507	-0.081	0.0675	NS
LUSC	Lung squamous cell carcinoma	497	0.016	0.727	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.206	0.000324	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.056	0.459	NS
READ	Rectum adenocarcinoma	156	0.058	0.474	NS
SKCM	Skin Cutaneous Melanoma	410	-0.03	0.541	NS
STAD	Stomach adenocarcinoma	392	-0.073	0.15	NS
TGCT	Testicular Germ Cell Tumors	81	0.08	0.479	NS
THCA	Thyroid carcinoma	499	-0.064	0.151	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.021	0.64	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.055	0.368	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.163	0.000253	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.008	0.862	NS
LGG	Brain Lower Grade Glioma	514	-0.088	0.0451	Lower
LIHC	Liver hepatocellular carcinoma	366	0.118	0.0235	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.056	0.337	NS
PAAD	Pancreatic adenocarcinoma	176	-0.003	0.964	NS
STAD	Stomach adenocarcinoma	406	-0.202	4.17e-05	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.069	0.109	NS

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for ATAT1.

Summary
Symbol	ATAT1
Name	alpha tubulin acetyltransferase 1
Aliases	FLJ13158; Em:AB023049.7; MEC17; alpha-tubulin N-acetyltransferase; C6orf134; chromosome 6 open reading frame ......
Location	6p21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
24096005	Pancreatic Carcinoma	partner	DLCK1	association	Cells that expressed DCLK1 also expressed high levels of ATAT1, HES1, HEY1, IGF1R, and ABL1, and manipulation of these pathways in PDAC cell lines inhibited their clonogenic potential.