CR2Cancer

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00439 Bromodomain
PF00400 WD domain

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3	#	22464331

> Gene Ontology [ TOP ]
Biological Process	GO:0008360 regulation of cell shape GO:0022604 regulation of cell morphogenesis
Molecular Function	-
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4620893	c.31G>A	p.E11K	Substitution - Missense	Large_intestine
COSM1660801	c.5090G>T	p.R1697L	Substitution - Missense	Kidney
COSM1682746	c.1973A>C	p.Q658P	Substitution - Missense	Large_intestine
COSM1491300	c.789T>C	p.H263H	Substitution - coding silent	Breast
COSM3563674	c.3991C>T	p.L1331F	Substitution - Missense	Skin
COSM1715208	c.2372G>T	p.R791L	Substitution - Missense	Skin
COSM1497313	c.5240T>A	p.I1747N	Substitution - Missense	Kidney
COSM4433604	c.2065G>C	p.D689H	Substitution - Missense	Oesophagus
COSM367931	c.4664T>C	p.L1555P	Substitution - Missense	Lung
COSM1125859	c.2053A>C	p.S685R	Substitution - Missense	Endometrium
COSM4534095	c.2049G>A	p.L683L	Substitution - coding silent	Skin
COSM758301	c.1746C>A	p.H582Q	Substitution - Missense	Lung
COSM3563686	c.1429G>A	p.D477N	Substitution - Missense	Skin
COSM1626158	c.2476-2A>G	p.?	Unknown	Liver
COSM4666264	c.3903T>C	p.N1301N	Substitution - coding silent	Large_intestine
COSM1316615	c.2458T>A	p.S820T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1125863	c.1672C>T	p.H558Y	Substitution - Missense	Endometrium
COSM3845463	c.4174A>G	p.K1392E	Substitution - Missense	Breast
COSM4821041	c.791C>T	p.S264L	Substitution - Missense	Cervix
COSM3726313	c.706C>T	p.L236F	Substitution - Missense	Lung
COSM5748314	c.644T>C	p.L215P	Substitution - Missense	Pancreas
COSM1729665	c.658G>C	p.G220R	Substitution - Missense	Liver
COSM5351657	c.1278G>A	p.V426V	Substitution - coding silent	Lung
COSM1469606	c.713C>T	p.A238V	Substitution - Missense	Large_intestine
COSM1125838	c.3277G>T	p.E1093*	Substitution - Nonsense	Endometrium
COSM5028960	c.4830A>G	p.G1610G	Substitution - coding silent	Breast
COSM4773905	c.1271T>C	p.L424P	Substitution - Missense	Stomach
COSM758306	c.2242G>A	p.E748K	Substitution - Missense	Lung
COSM758303	c.1924C>A	p.Q642K	Substitution - Missense	Lung
COSM169244	c.655C>T	p.R219C	Substitution - Missense	Skin
COSM758305	c.2044+2T>A	p.?	Unknown	Lung
COSM488664	c.3181G>A	p.A1061T	Substitution - Missense	Kidney
COSM1125898	c.180G>C	p.L60L	Substitution - coding silent	Endometrium
COSM1682745	c.2095C>T	p.R699*	Substitution - Nonsense	Large_intestine
COSM1686328	c.754C>T	p.R252*	Substitution - Nonsense	Prostate
COSM159423	c.5174G>A	p.R1725Q	Substitution - Missense	Breast
COSM1469609	c.112G>A	p.E38K	Substitution - Missense	Large_intestine
COSM3965562	c.1651-2A>G	p.?	Unknown	Lung
COSM68968	c.1029_1042del14	p.I344fs*2	Deletion - Frameshift	Ovary
COSM1125819	c.4241G>T	p.S1414I	Substitution - Missense	Endometrium
COSM6018613	c.549C>G	p.V183V	Substitution - coding silent	Skin
COSM462171	c.2925G>A	p.W975*	Substitution - Nonsense	Cervix
COSM1125896	c.335G>A	p.C112Y	Substitution - Missense	Endometrium
COSM4389577	c.592-4A>C	p.?	Unknown	Pancreas
COSM5038683	c.5061_5075del15	p.G1691_G1695delGRGRG	Deletion - In frame	Liver
COSM758302	c.1862G>T	p.G621V	Substitution - Missense	Lung
COSM4666260	c.4872C>T	p.D1624D	Substitution - coding silent	Large_intestine
COSM1125811	c.4634G>T	p.R1545I	Substitution - Missense	Endometrium
COSM5500308	c.3527C>A	p.P1176H	Substitution - Missense	Biliary_tract
COSM4399746	c.1662G>A	p.Q554Q	Substitution - coding silent	Skin
COSM82030	c.1116C>T	p.N372N	Substitution - coding silent	Ovary
COSM5468129	c.3905C>A	p.P1302H	Substitution - Missense	Large_intestine
COSM363532	c.5092G>A	p.G1698R	Substitution - Missense	Skin
COSM1469598	c.1336C>A	p.L446I	Substitution - Missense	Large_intestine
COSM5450671	c.1932G>A	p.E644E	Substitution - coding silent	Large_intestine
COSM5028962	c.430+1G>A	p.?	Unknown	Breast
COSM3694725	c.3593G>A	p.R1198H	Substitution - Missense	Large_intestine
COSM4666265	c.2722-2delA	p.?	Unknown	Large_intestine
COSM3973966	c.5205C>T	p.T1735T	Substitution - coding silent	Central_nervous_system
COSM5646507	c.4687G>A	p.D1563N	Substitution - Missense	Oesophagus
COSM758298	c.714T>C	p.A238A	Substitution - coding silent	Lung
COSM3097821	c.3971C>A	p.P1324Q	Substitution - Missense	Large_intestine
COSM3396431	c.3775G>A	p.A1259T	Substitution - Missense	Prostate
COSM3097870	c.748T>C	p.C250R	Substitution - Missense	Large_intestine
COSM4111260	c.5379G>A	p.R1793R	Substitution - coding silent	Stomach
COSM1636620	c.2196A>G	p.R732R	Substitution - coding silent	Liver
COSM5461338	c.552C>T	p.Y184Y	Substitution - coding silent	Large_intestine
COSM4666263	c.3921_3922insA	p.Q1308fs*11	Insertion - Frameshift	Large_intestine
COSM1190584	c.5342G>A	p.R1781K	Substitution - Missense	Lung
COSM388043	c.1646A>G	p.E549G	Substitution - Missense	Lung
COSM1125813	c.4627C>T	p.R1543W	Substitution - Missense	Endometrium
COSM385608	c.3809A>T	p.D1270V	Substitution - Missense	Lung
COSM1125853	c.2372G>A	p.R791H	Substitution - Missense	Large_intestine
COSM3727459	c.3209A>G	p.Q1070R	Substitution - Missense	Skin
COSM4471916	c.1749C>T	p.L583L	Substitution - coding silent	Skin
COSM4157030	c.148G>C	p.G50R	Substitution - Missense	Thyroid
COSM1469580	c.5116G>C	p.G1706R	Substitution - Missense	Large_intestine
COSM5905148	c.1876+2T>C	p.?	Unknown	Skin
COSM196957	c.4813G>A	p.E1605K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1644086	c.3418delG	p.A1140fs*42	Deletion - Frameshift	Stomach
COSM5990917	c.3538_3545delACTGTAGT	p.T1180fs*5	Deletion - Frameshift	Prostate
COSM256420	c.1385C>A	p.S462Y	Substitution - Missense	Large_intestine
COSM1715209	c.766_767CC>TT	p.P256F	Substitution - Missense	Skin
COSM4758040	c.4899A>C	p.Q1633H	Substitution - Missense	Stomach
COSM1626159	c.814-4delT	p.?	Unknown	Oesophagus
COSM5413153	c.1459G>A	p.D487N	Substitution - Missense	Skin
COSM3563673	c.4443C>T	p.D1481D	Substitution - coding silent	Skin
COSM3563682	c.2593G>A	p.G865R	Substitution - Missense	Skin
COSM1125807	c.4801T>G	p.L1601V	Substitution - Missense	Endometrium
COSM3563683	c.2418T>A	p.N806K	Substitution - Missense	Large_intestine
COSM488666	c.860G>C	p.G287A	Substitution - Missense	Kidney
COSM5750967	c.2554G>T	p.D852Y	Substitution - Missense	Stomach
COSM144795	c.362C>G	p.A121G	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5584578	c.2618G>A	p.R873K	Substitution - Missense	Skin
COSM5909951	c.2650A>T	p.S884C	Substitution - Missense	Skin
COSM5711781	c.4361G>T	p.S1454I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4589552	c.4757G>A	p.G1586E	Substitution - Missense	Bone
COSM5549994	c.1450G>A	p.A484T	Substitution - Missense	Prostate
COSM3965560	c.4141G>T	p.A1381S	Substitution - Missense	Lung
COSM3406621	c.631G>A	p.D211N	Substitution - Missense	Central_nervous_system
COSM4111265	c.3082C>T	p.P1028S	Substitution - Missense	Stomach
COSM389740	c.5138G>T	p.G1713V	Substitution - Missense	Lung
COSM4832209	c.3955C>A	p.R1319S	Substitution - Missense	Cervix
COSM367786	c.524G>T	p.R175I	Substitution - Missense	Lung
COSM3563679	c.3433G>A	p.E1145K	Substitution - Missense	Skin
COSM3563668	c.5129G>A	p.G1710E	Substitution - Missense	Skin
COSM196959	c.3976C>T	p.R1326*	Substitution - Nonsense	Endometrium
COSM1125849	c.2673G>T	p.L891F	Substitution - Missense	Endometrium
COSM5549994	c.1450G>A	p.A484T	Substitution - Missense	Prostate
COSM758312	c.5030G>A	p.G1677E	Substitution - Missense	Lung
COSM5413154	c.1336C>T	p.L446F	Substitution - Missense	Skin
COSM3563677	c.3733C>T	p.Q1245*	Substitution - Nonsense	Skin
COSM1283684	c.1756C>T	p.P586S	Substitution - Missense	Autonomic_ganglia
COSM5482356	c.914+6T>C	p.?	Unknown	Large_intestine
COSM3380262	c.534G>T	p.G178G	Substitution - coding silent	Pancreas
COSM1125861	c.1939C>A	p.L647I	Substitution - Missense	Endometrium
COSM1469601	c.1162G>A	p.A388T	Substitution - Missense	Large_intestine
COSM3940130	c.43C>T	p.L15L	Substitution - coding silent	Oesophagus
COSM1626157	c.2838T>C	p.L946L	Substitution - coding silent	Liver
COSM3097852	c.1807C>T	p.R603W	Substitution - Missense	Stomach
COSM4111267	c.2522T>C	p.V841A	Substitution - Missense	Stomach
COSM1125889	c.755G>A	p.R252Q	Substitution - Missense	Endometrium
COSM3563672	c.4528C>T	p.L1510L	Substitution - coding silent	Skin
COSM3097798	c.5305G>A	p.V1769M	Substitution - Missense	Large_intestine
COSM3424982	c.4170T>G	p.F1390L	Substitution - Missense	Large_intestine
COSM4111269	c.1907G>A	p.G636E	Substitution - Missense	Stomach
COSM3914264	c.4183C>T	p.R1395C	Substitution - Missense	Skin
COSM4832922	c.596C>T	p.S199L	Substitution - Missense	Cervix
COSM758311	c.4603G>T	p.D1535Y	Substitution - Missense	Lung
COSM1319411	c.1118A>G	p.N373S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4489439	c.3476C>T	p.S1159F	Substitution - Missense	Skin
COSM1125813	c.4627C>T	p.R1543W	Substitution - Missense	Large_intestine
COSM1125871	c.1376A>G	p.H459R	Substitution - Missense	Endometrium
COSM3563675	c.3914G>T	p.W1305L	Substitution - Missense	Skin
COSM1682743	c.4003C>A	p.P1335T	Substitution - Missense	Large_intestine
COSM3406620	c.2638C>T	p.R880C	Substitution - Missense	Central_nervous_system
COSM1125821	c.4189A>T	p.I1397L	Substitution - Missense	Endometrium
COSM1125797	c.5215G>T	p.G1739*	Substitution - Nonsense	Endometrium
COSM367786	c.524G>T	p.R175I	Substitution - Missense	Endometrium
COSM4666261	c.4718G>T	p.R1573I	Substitution - Missense	Large_intestine
COSM4654575	c.223A>G	p.I75V	Substitution - Missense	Large_intestine
COSM5513830	c.2043T>C	p.G681G	Substitution - coding silent	Biliary_tract
COSM4111271	c.1678G>A	p.D560N	Substitution - Missense	Stomach
COSM1715207	c.4622C>T	p.S1541L	Substitution - Missense	Skin
COSM5673888	c.3673A>T	p.S1225C	Substitution - Missense	Soft_tissue
COSM1469604	c.985+2T>C	p.?	Unknown	Large_intestine
COSM5504787	c.3069G>T	p.K1023N	Substitution - Missense	Biliary_tract
COSM1316526	c.5062G>T	p.G1688*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4111263	c.3846T>C	p.G1282G	Substitution - coding silent	Stomach
COSM4111265	c.3082C>T	p.P1028S	Substitution - Missense	Large_intestine
COSM196956	c.4988G>T	p.R1663I	Substitution - Missense	Large_intestine
COSM1125861	c.1939C>A	p.L647I	Substitution - Missense	Endometrium
COSM1469582	c.4572C>T	p.F1524F	Substitution - coding silent	Large_intestine
COSM4111262	c.4177G>T	p.D1393Y	Substitution - Missense	Stomach
COSM1246262	c.1847T>A	p.L616H	Substitution - Missense	Oesophagus
COSM3800778	c.5316G>C	p.E1772D	Substitution - Missense	Urinary_tract
COSM5501262	c.2495C>T	p.T832I	Substitution - Missense	Biliary_tract
COSM5654611	c.2836-2A>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4462439	c.1247C>T	p.S416F	Substitution - Missense	Skin
COSM1682745	c.2095C>T	p.R699*	Substitution - Nonsense	Large_intestine
COSM1469591	c.3238A>T	p.S1080C	Substitution - Missense	Large_intestine
COSM1125873	c.1337T>C	p.L446P	Substitution - Missense	Endometrium
COSM3992591	c.446C>T	p.A149V	Substitution - Missense	Kidney
COSM1469581	c.4694G>A	p.R1565K	Substitution - Missense	Upper_aerodigestive_tract
COSM1644085	c.5173C>T	p.R1725*	Substitution - Nonsense	Stomach
COSM3845468	c.1649A>G	p.K550R	Substitution - Missense	Breast
COSM4657455	c.33G>A	p.E11E	Substitution - coding silent	Parathyroid
COSM1682746	c.1973A>C	p.Q658P	Substitution - Missense	Large_intestine
COSM4636544	c.243T>C	p.P81P	Substitution - coding silent	Large_intestine
COSM3563678	c.3715C>T	p.L1239F	Substitution - Missense	Skin
COSM5064905	c.3488C>T	p.A1163V	Substitution - Missense	Stomach
COSM5587305	c.2482G>A	p.E828K	Substitution - Missense	Skin
COSM309540	c.906G>T	p.M302I	Substitution - Missense	Lung
COSM1315718	c.2143G>T	p.A715S	Substitution - Missense	Urinary_tract
COSM4390695	c.171C>T	p.F57F	Substitution - coding silent	Breast
COSM3786782	c.3432C>T	p.D1144D	Substitution - coding silent	Breast
COSM5900650	c.3841C>T	p.P1281S	Substitution - Missense	Skin
COSM1469605	c.921C>T	p.R307R	Substitution - coding silent	Large_intestine
COSM1125855	c.2176C>A	p.L726I	Substitution - Missense	Endometrium
COSM3940128	c.4382G>T	p.S1461I	Substitution - Missense	Oesophagus
COSM3424983	c.637C>T	p.R213C	Substitution - Missense	Stomach
COSM3965561	c.2400G>T	p.R800R	Substitution - coding silent	Lung
COSM4880346	c.2232-5A>G	p.?	Unknown	Prostate
COSM5694409	c.2361C>A	p.R787R	Substitution - coding silent	Soft_tissue
COSM4420678	c.3891T>C	p.S1297S	Substitution - coding silent	Central_nervous_system
COSM4839951	c.819T>C	p.C273C	Substitution - coding silent	Cervix
COSM3845464	c.3187T>G	p.W1063G	Substitution - Missense	Breast
COSM3563671	c.4570T>C	p.F1524L	Substitution - Missense	Skin
COSM1125893	c.581G>T	p.R194I	Substitution - Missense	Endometrium
COSM5003138	c.1255G>A	p.D419N	Substitution - Missense	Pancreas
COSM1626156	c.3146A>G	p.Q1049R	Substitution - Missense	Liver
COSM4823952	c.2326-1G>A	p.?	Unknown	Cervix
COSM5498709	c.814-5_814-4delTT	p.?	Unknown	Biliary_tract
COSM1469594	c.2242G>T	p.E748*	Substitution - Nonsense	Large_intestine
COSM4949921	c.4172A>T	p.Y1391F	Substitution - Missense	Liver
COSM1636619	c.3637A>G	p.I1213V	Substitution - Missense	Liver
COSM3563684	c.1803C>T	p.F601F	Substitution - coding silent	Skin
COSM213604	c.4900G>T	p.D1634Y	Substitution - Missense	Breast
COSM5779120	c.1057G>A	p.E353K	Substitution - Missense	Breast
COSM1682744	c.2173G>T	p.D725Y	Substitution - Missense	Large_intestine
COSM3563670	c.4862C>T	p.S1621F	Substitution - Missense	Skin
COSM196959	c.3976C>T	p.R1326*	Substitution - Nonsense	Endometrium
COSM1125900	c.48C>T	p.I16I	Substitution - coding silent	Endometrium
COSM5634426	c.214C>G	p.L72V	Substitution - Missense	Oesophagus
COSM4953545	c.910T>G	p.F304V	Substitution - Missense	Liver
COSM3563685	c.1684C>T	p.R562C	Substitution - Missense	Skin
COSM1469585	c.4352G>T	p.R1451L	Substitution - Missense	Large_intestine
COSM1125805	c.4905C>T	p.Y1635Y	Substitution - coding silent	Endometrium
COSM758295	c.88C>T	p.Q30*	Substitution - Nonsense	Lung
COSM5436888	c.3370G>A	p.E1124K	Substitution - Missense	Oesophagus
COSM4111273	c.568C>T	p.R190*	Substitution - Nonsense	Stomach
COSM5688317	c.109G>T	p.E37*	Substitution - Nonsense	Soft_tissue
COSM5498709	c.814-5_814-4delTT	p.?	Unknown	Biliary_tract
COSM1184982	c.1085C>T	p.T362M	Substitution - Missense	Large_intestine
COSM1723869	c.820C>T	p.P274S	Substitution - Missense	Skin
COSM1125869	c.1408G>A	p.V470I	Substitution - Missense	Endometrium
COSM3097869	c.768C>T	p.P256P	Substitution - coding silent	Large_intestine
COSM1125801	c.5037G>A	p.W1679*	Substitution - Nonsense	Endometrium
COSM4927533	c.1244C>T	p.P415L	Substitution - Missense	Liver
COSM360629	c.1975G>T	p.D659Y	Substitution - Missense	Lung
COSM1686328	c.754C>T	p.R252*	Substitution - Nonsense	Skin
COSM1723869	c.820C>T	p.P274S	Substitution - Missense	Skin
COSM5725276	c.3635A>G	p.Y1212C	Substitution - Missense	Skin
COSM1125830	c.3718C>T	p.R1240*	Substitution - Nonsense	Skin
COSM231858	c.652C>T	p.L218F	Substitution - Missense	Skin
COSM1732252	c.488C>T	p.P163L	Substitution - Missense	Bone
COSM6005199	c.2682A>G	p.L894L	Substitution - coding silent	Prostate
COSM1125875	c.1298G>A	p.R433H	Substitution - Missense	Endometrium
COSM3786782	c.3432C>T	p.D1144D	Substitution - coding silent	Pancreas
COSM3845471	c.765A>C	p.A255A	Substitution - coding silent	Breast
COSM367932	c.3956G>T	p.R1319L	Substitution - Missense	Lung
COSM1283683	c.1720G>T	p.D574Y	Substitution - Missense	Autonomic_ganglia
COSM3406619	c.4252C>T	p.R1418*	Substitution - Nonsense	Central_nervous_system
COSM758310	c.4462C>T	p.H1488Y	Substitution - Missense	Skin
COSM196956	c.4988G>T	p.R1663I	Substitution - Missense	Large_intestine
COSM4136402	c.592-3T>C	p.?	Unknown	Ovary
COSM1331673	c.3860G>A	p.R1287K	Substitution - Missense	Ovary
COSM4492964	c.4076C>T	p.S1359F	Substitution - Missense	Skin
COSM4492766	c.4031C>T	p.S1344F	Substitution - Missense	Skin
COSM4499469	c.542C>T	p.S181L	Substitution - Missense	Skin
COSM5457501	c.4906G>A	p.V1636I	Substitution - Missense	Large_intestine
COSM213379	c.734T>C	p.V245A	Substitution - Missense	Breast
COSM4111264	c.3211C>T	p.Q1071*	Substitution - Nonsense	Stomach
COSM370639	c.238G>T	p.G80C	Substitution - Missense	Lung
COSM364856	c.3568A>T	p.T1190S	Substitution - Missense	Lung
COSM3097837	c.2637A>G	p.T879T	Substitution - coding silent	Large_intestine
COSM1125847	c.2888C>T	p.S963L	Substitution - Missense	Endometrium
COSM4666258	c.5218C>T	p.R1740C	Substitution - Missense	Large_intestine
COSM4832042	c.1448C>T	p.S483L	Substitution - Missense	Cervix
COSM5911093	c.5045G>A	p.W1682*	Substitution - Nonsense	Skin
COSM4387032	c.656G>A	p.R219H	Substitution - Missense	Lung
COSM1125887	c.763G>T	p.A255S	Substitution - Missense	Endometrium
COSM5553643	c.1894G>A	p.E632K	Substitution - Missense	Prostate
COSM4758043	c.3107T>G	p.L1036R	Substitution - Missense	Stomach
COSM5514378	c.3445C>T	p.R1149W	Substitution - Missense	Biliary_tract
COSM3364114	c.4017G>A	p.E1339E	Substitution - coding silent	Kidney
COSM1469593	c.2442A>G	p.S814S	Substitution - coding silent	Large_intestine
COSM3845467	c.2248C>T	p.R750*	Substitution - Nonsense	Breast
COSM1469587	c.3793A>G	p.T1265A	Substitution - Missense	Large_intestine
COSM256419	c.3242C>A	p.S1081Y	Substitution - Missense	Large_intestine
COSM196959	c.3976C>T	p.R1326*	Substitution - Nonsense	Endometrium
COSM758300	c.810A>T	p.I270I	Substitution - coding silent	Lung
COSM1469603	c.1086+2T>C	p.?	Unknown	Large_intestine
COSM758307	c.3502G>A	p.V1168I	Substitution - Missense	Lung
COSM3708738	c.2658T>C	p.S886S	Substitution - coding silent	Liver
COSM3914266	c.3412T>G	p.W1138G	Substitution - Missense	Skin
COSM1125817	c.4314C>T	p.I1438I	Substitution - coding silent	Endometrium
COSM5494289	c.1262T>C	p.I421T	Substitution - Missense	Biliary_tract
COSM4111272	c.1490G>A	p.R497Q	Substitution - Missense	Stomach
COSM1184981	c.4927A>T	p.S1643C	Substitution - Missense	Large_intestine
COSM3097830	c.3286A>C	p.K1096Q	Substitution - Missense	Large_intestine
COSM1316614	c.2464A>C	p.S822R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1125877	c.1166G>T	p.R389I	Substitution - Missense	Endometrium
COSM4855331	c.4565C>T	p.S1522L	Substitution - Missense	Cervix
COSM69852	c.3701T>G	p.V1234G	Substitution - Missense	Ovary
COSM4666269	c.471C>T	p.R157R	Substitution - coding silent	Large_intestine
COSM3669013	c.778C>A	p.L260I	Substitution - Missense	Liver
COSM3845470	c.1059G>C	p.E353D	Substitution - Missense	Breast
COSM1682743	c.4003C>A	p.P1335T	Substitution - Missense	Large_intestine
COSM309543	c.2194A>G	p.R732G	Substitution - Missense	Lung
COSM4832089	c.3564C>T	p.L1188L	Substitution - coding silent	Cervix
COSM1283682	c.1685G>A	p.R562H	Substitution - Missense	Autonomic_ganglia
COSM4111270	c.1773T>A	p.D591E	Substitution - Missense	Stomach
COSM1125830	c.3718C>T	p.R1240*	Substitution - Nonsense	Endometrium
COSM4953545	c.910T>G	p.F304V	Substitution - Missense	Liver
COSM1125883	c.919C>T	p.R307C	Substitution - Missense	Endometrium
COSM5005263	c.3719G>C	p.R1240P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5028961	c.3939G>T	p.L1313F	Substitution - Missense	Breast
COSM5769067	c.920G>A	p.R307H	Substitution - Missense	Breast
COSM5794787	c.937G>C	p.E313Q	Substitution - Missense	Breast
COSM3713936	c.3352G>T	p.G1118C	Substitution - Missense	Upper_aerodigestive_tract
COSM5554783	c.5143G>A	p.G1715S	Substitution - Missense	Prostate
COSM3845465	c.3124G>A	p.E1042K	Substitution - Missense	Breast
COSM309542	c.3446G>A	p.R1149Q	Substitution - Missense	Large_intestine
COSM3097884	c.84C>T	p.S28S	Substitution - coding silent	Large_intestine
COSM3940129	c.2872C>T	p.R958W	Substitution - Missense	Oesophagus
COSM758310	c.4462C>T	p.H1488Y	Substitution - Missense	Lung
COSM3708738	c.2658T>C	p.S886S	Substitution - coding silent	Liver
COSM309543	c.2194A>G	p.R732G	Substitution - Missense	Soft_tissue
COSM1125885	c.842G>T	p.R281I	Substitution - Missense	Endometrium
COSM4111261	c.4928G>A	p.S1643N	Substitution - Missense	Stomach
COSM4931855	c.1593A>G	p.T531T	Substitution - coding silent	Liver
COSM4849463	c.778C>G	p.L260V	Substitution - Missense	Cervix
COSM1190585	c.2869G>T	p.V957F	Substitution - Missense	Lung
COSM4880081	c.1982G>C	p.R661T	Substitution - Missense	Prostate
COSM458123	c.5097A>T	p.R1699S	Substitution - Missense	Breast
COSM1469607	c.638G>A	p.R213H	Substitution - Missense	Large_intestine
COSM1125865	c.1642T>C	p.Y548H	Substitution - Missense	Endometrium
COSM1125867	c.1635T>C	p.S545S	Substitution - coding silent	Endometrium
COSM1469608	c.179T>C	p.L60P	Substitution - Missense	Large_intestine
COSM1125851	c.2595A>T	p.G865G	Substitution - coding silent	Endometrium
COSM3563688	c.1359C>T	p.I453I	Substitution - coding silent	Skin
COSM3786782	c.3432C>T	p.D1144D	Substitution - coding silent	Skin
COSM1125809	c.4669G>T	p.G1557*	Substitution - Nonsense	Endometrium
COSM1316527	c.5061A>C	p.R1687S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4666266	c.1160C>T	p.T387M	Substitution - Missense	Large_intestine
COSM4666267	c.986-2A>G	p.?	Unknown	Large_intestine
COSM3097870	c.748T>C	p.C250R	Substitution - Missense	Large_intestine
COSM5748313	c.1496C>T	p.T499I	Substitution - Missense	Pancreas
COSM238989	c.3551A>C	p.Y1184S	Substitution - Missense	Prostate
COSM5431999	c.5296G>C	p.D1766H	Substitution - Missense	Oesophagus
COSM1686328	c.754C>T	p.R252*	Substitution - Nonsense	Skin
COSM224623	c.4661C>T	p.S1554F	Substitution - Missense	Skin
COSM256421	c.485T>C	p.F162S	Substitution - Missense	Large_intestine
COSM1125815	c.4364G>A	p.S1455N	Substitution - Missense	Endometrium
COSM4666268	c.623C>A	p.A208D	Substitution - Missense	Large_intestine
COSM3914265	c.4087C>T	p.Q1363*	Substitution - Nonsense	Skin
COSM3563676	c.3851C>T	p.S1284L	Substitution - Missense	Skin
COSM309541	c.892C>A	p.H298N	Substitution - Missense	Lung
COSM1125826	c.3728+1G>A	p.?	Unknown	Endometrium
COSM3364113	c.4146A>G	p.G1382G	Substitution - coding silent	Kidney
COSM4993605	c.634delG	p.G212fs*34	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1246263	c.4487C>T	p.S1496L	Substitution - Missense	Oesophagus
COSM4931590	c.765A>G	p.A255A	Substitution - coding silent	Liver
COSM458125	c.1489C>T	p.R497W	Substitution - Missense	Biliary_tract
COSM4453259	c.2722A>C	p.K908Q	Substitution - Missense	Skin
COSM758297	c.693C>G	p.N231K	Substitution - Missense	Lung
COSM5434238	c.3640G>A	p.E1214K	Substitution - Missense	Oesophagus
COSM1125819	c.4241G>T	p.S1414I	Substitution - Missense	Soft_tissue
COSM3424983	c.637C>T	p.R213C	Substitution - Missense	Large_intestine
COSM5784206	c.1155T>C	p.D385D	Substitution - coding silent	Breast
COSM4949921	c.4172A>T	p.Y1391F	Substitution - Missense	Liver
COSM1125803	c.4959A>T	p.K1653N	Substitution - Missense	Endometrium
COSM196959	c.3976C>T	p.R1326*	Substitution - Nonsense	Large_intestine
COSM1730876	c.4349A>C	p.K1450T	Substitution - Missense	Liver
COSM758304	c.1939C>G	p.L647V	Substitution - Missense	Lung
COSM1125832	c.3610T>C	p.S1204P	Substitution - Missense	Endometrium
COSM1626157	c.2838T>C	p.L946L	Substitution - coding silent	Liver
COSM1469586	c.4167A>G	p.E1389E	Substitution - coding silent	Large_intestine
COSM5413156	c.491C>T	p.S164L	Substitution - Missense	Skin
COSM309544	c.4062_4068delAGATTCA	p.Q1354fs*11	Deletion - Frameshift	Lung
COSM5783395	c.2715A>T	p.R905S	Substitution - Missense	Breast
COSM1125857	c.2119G>T	p.G707C	Substitution - Missense	Endometrium
COSM1125845	c.3003C>T	p.C1001C	Substitution - coding silent	Endometrium
COSM5785203	c.331+5G>T	p.?	Unknown	Breast
COSM3406619	c.4252C>T	p.R1418*	Substitution - Nonsense	Large_intestine
COSM1125836	c.3319G>T	p.E1107*	Substitution - Nonsense	Endometrium
COSM1469596	c.1980G>T	p.L660L	Substitution - coding silent	Large_intestine
COSM196962	c.2359C>T	p.R787C	Substitution - Missense	Large_intestine
COSM3563683	c.2418T>A	p.N806K	Substitution - Missense	Skin
COSM4819838	c.161G>A	p.R54Q	Substitution - Missense	Cervix
COSM1626156	c.3146A>G	p.Q1049R	Substitution - Missense	Liver
COSM159422	c.3403G>C	p.E1135Q	Substitution - Missense	Breast
COSM758299	c.772G>T	p.A258S	Substitution - Missense	Lung
COSM1717560	c.974C>G	p.S325C	Substitution - Missense	Ovary
COSM5772690	c.2618G>C	p.R873T	Substitution - Missense	Breast
COSM4629063	c.1191A>G	p.E397E	Substitution - coding silent	Large_intestine
COSM5413152	c.2515G>A	p.D839N	Substitution - Missense	Skin
COSM4848341	c.1977C>T	p.D659D	Substitution - coding silent	Cervix
COSM4540196	c.2801G>A	p.R934Q	Substitution - Missense	Skin
COSM1469597	c.1565C>T	p.S522L	Substitution - Missense	Large_intestine
COSM4963432	c.2472A>T	p.S824S	Substitution - coding silent	Pancreas
COSM367932	c.3956G>T	p.R1319L	Substitution - Missense	Prostate
COSM1125828	c.3719G>A	p.R1240Q	Substitution - Missense	Endometrium
COSM4111266	c.2932A>T	p.M978L	Substitution - Missense	Stomach
COSM458122	c.5314G>A	p.E1772K	Substitution - Missense	Breast
COSM758308	c.3728G>T	p.G1243V	Substitution - Missense	Lung
COSM5936762	c.3602+3C>T	p.?	Unknown	Skin
COSM1125883	c.919C>T	p.R307C	Substitution - Missense	Breast
COSM4820572	c.5130G>C	p.G1710G	Substitution - coding silent	Cervix
COSM1243108	c.3364T>C	p.S1122P	Substitution - Missense	Oesophagus
COSM5792857	c.129G>A	p.P43P	Substitution - coding silent	Breast
COSM3563669	c.4918C>T	p.H1640Y	Substitution - Missense	Skin
COSM758296	c.347T>A	p.L116Q	Substitution - Missense	Lung
COSM1315717	c.4514G>C	p.G1505A	Substitution - Missense	Urinary_tract
COSM1184980	c.334T>C	p.C112R	Substitution - Missense	Large_intestine
COSM3845462	c.5359A>G	p.K1787E	Substitution - Missense	Breast
COSM5687122	c.4398-2A>T	p.?	Unknown	Soft_tissue
COSM4111268	c.2351G>A	p.R784H	Substitution - Missense	Stomach
COSM1331674	c.4901A>T	p.D1634V	Substitution - Missense	Ovary
COSM4666262	c.4253G>A	p.R1418Q	Substitution - Missense	Large_intestine
COSM243249	c.799A>C	p.I267L	Substitution - Missense	Prostate
COSM1578688	c.3144G>C	p.W1048C	Substitution - Missense	Meninges
COSM5759006	c.1189G>C	p.E397Q	Substitution - Missense	Bone
COSM5725276	c.3635A>G	p.Y1212C	Substitution - Missense	Skin
COSM309542	c.3446G>A	p.R1149Q	Substitution - Missense	Lung
COSM234454	c.651A>T	p.T217T	Substitution - coding silent	Skin
COSM458125	c.1489C>T	p.R497W	Substitution - Missense	Large_intestine
COSM5666922	c.3442G>T	p.E1148*	Substitution - Nonsense	Soft_tissue
COSM5791566	c.5132G>C	p.R1711T	Substitution - Missense	Breast
COSM318951	c.2590G>A	p.A864T	Substitution - Missense	Lung
COSM300572	c.4944C>A	p.T1648T	Substitution - coding silent	Large_intestine
COSM1125853	c.2372G>A	p.R791H	Substitution - Missense	Endometrium
COSM1125881	c.960G>T	p.Q320H	Substitution - Missense	Endometrium
COSM1469592	c.3061T>C	p.S1021P	Substitution - Missense	Large_intestine
COSM385751	c.3267G>T	p.W1089C	Substitution - Missense	Lung
COSM3713936	c.3352G>T	p.G1118C	Substitution - Missense	Upper_aerodigestive_tract
COSM458127	c.923C>G	p.P308R	Substitution - Missense	Breast
COSM363532	c.5092G>A	p.G1698R	Substitution - Missense	Lung
COSM3845466	c.2776C>T	p.Q926*	Substitution - Nonsense	Breast
COSM5413155	c.529C>G	p.L177V	Substitution - Missense	Skin
COSM1626159	c.814-4delT	p.?	Unknown	Liver
COSM79145	c.4499C>G	p.S1500*	Substitution - Nonsense	Ovary
COSM5927929	c.4982G>A	p.G1661E	Substitution - Missense	Skin
COSM3563689	c.1153G>A	p.D385N	Substitution - Missense	Skin
COSM458125	c.1489C>T	p.R497W	Substitution - Missense	Breast
COSM1682744	c.2173G>T	p.D725Y	Substitution - Missense	Large_intestine
COSM5801423	c.3845delG	p.G1282fs*17	Deletion - Frameshift	Breast
COSM258737	c.3751C>G	p.L1251V	Substitution - Missense	Large_intestine
COSM4976384	c.627A>C	p.T209T	Substitution - coding silent	Oesophagus
COSM458126	c.980G>A	p.S327N	Substitution - Missense	Breast
COSM1125824	c.3784C>T	p.R1262*	Substitution - Nonsense	Endometrium
COSM5498709	c.814-5_814-4delTT	p.?	Unknown	Biliary_tract
COSM458124	c.1771G>C	p.D591H	Substitution - Missense	Breast
COSM4629063	c.1191A>G	p.E397E	Substitution - coding silent	Skin
COSM1125879	c.1127G>A	p.S376N	Substitution - Missense	Endometrium
COSM1125843	c.3052G>T	p.E1018*	Substitution - Nonsense	Endometrium
COSM5638396	c.5200G>A	p.D1734N	Substitution - Missense	Oesophagus
COSM1469599	c.1233-1G>T	p.?	Unknown	Large_intestine
COSM3563680	c.3400C>T	p.Q1134*	Substitution - Nonsense	Skin
COSM374865	c.1592C>T	p.T531I	Substitution - Missense	Lung
COSM4396858	c.4989A>G	p.R1663R	Substitution - coding silent	Skin
COSM3563687	c.1407C>T	p.F469F	Substitution - coding silent	Skin
COSM1331672	c.3481+2T>A	p.?	Unknown	Ovary
COSM3563681	c.3247C>T	p.Q1083*	Substitution - Nonsense	Skin
COSM5666923	c.531G>T	p.L177L	Substitution - coding silent	Soft_tissue
COSM488664	c.3181G>A	p.A1061T	Substitution - Missense	Endometrium
COSM4963432	c.2472A>T	p.S824S	Substitution - coding silent	Pancreas
COSM6018612	c.1017C>T	p.D339D	Substitution - coding silent	Skin
COSM5064906	c.1324G>C	p.V442L	Substitution - Missense	Stomach
COSM488665	c.1845G>A	p.Q615Q	Substitution - coding silent	Kidney
COSM1125840	c.3226G>A	p.E1076K	Substitution - Missense	Endometrium
COSM5785255	c.2874G>T	p.R958R	Substitution - coding silent	Breast
COSM1125891	c.715G>A	p.A239T	Substitution - Missense	Endometrium
COSM1125834	c.3359C>A	p.P1120H	Substitution - Missense	Endometrium
COSM1125799	c.5174G>T	p.R1725L	Substitution - Missense	Endometrium
COSM1626158	c.2476-2A>G	p.?	Unknown	Liver
COSM4666259	c.5001C>G	p.T1667T	Substitution - coding silent	Large_intestine
COSM3845469	c.1151G>C	p.R384P	Substitution - Missense	Breast
COSM5645294	c.4713C>A	p.I1571I	Substitution - coding silent	Oesophagus

> Text Mining based Variations [ TOP ]
There is no record for BRWD3.

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q6RI45	703	S	Phosphoserine	-	No	None detected
Q6RI45	885	S	Phosphoserine	-	No	None detected
Q6RI45	886	S	Phosphoserine	-	No	None detected
Q6RI45	1577	S	Phosphoserine	-	No	None detected
Q6RI45	1579	S	Phosphoserine	-	No	None detected
Q6RI45	1763	S	Phosphoserine	-	No	None detected

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	2.918	2.962	0.213	0.45	NS
BRCA	Breast invasive carcinoma	112	1100	3.519	3.689	0.265	0.0131	NS
CESC	Cervical and endocervical cancers	3	306	1.228	3.484	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.472	3.597	0.129	0.419	NS
ESCA	Esophageal carcinoma	11	185	4.342	4.518	0.127	0.697	NS
GBM	Glioblastoma multiforme	5	166	2.159	2.217	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.85	3.469	-0.181	0.342	NS
KIRC	Kidney renal clear cell carcinoma	72	534	3.33	3.496	0.097	0.436	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	3.012	2.418	-0.547	0.0135	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.7	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	3.253	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	1.663	1.606	0.104	0.562	NS
LUAD	Lung adenocarcinoma	59	517	2.754	3.229	0.568	6.18e-06	NS
LUSC	Lung squamous cell carcinoma	51	501	2.982	3.627	0.666	4.59e-07	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	3	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.244	3.092	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	1.512	2.377	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	2.802	2.612	-0.134	0.407	NS
READ	Rectum adenocarcinoma	10	167	3.433	3.734	0.335	0.318	NS
SARC	Sarcoma	2	263	1.491	2.669	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	2.453	3.185	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	3.782	4.224	0.334	0.0345	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.212	NA	NA	NA
THCA	Thyroid carcinoma	59	509	3.272	2.58	-0.594	5.31e-06	Under
THYM	Thymoma	2	120	3.377	2.065	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	2.155	3.104	0.836	2.48e-07	Over

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	2.1
Adrenal gland	3.3
Appendix	6.4
Bone marrow	3.6
Breast	4
Cerebral cortex	3.6
Cervix, uterine	4.2
Colon	3.5
Duodenum	4.2
Endometrium	4.9
Epididymis	3.3
Esophagus	4.3
Fallopian tube	3.7
Gallbladder	4.4
Heart muscle	0.9
Kidney	2.7
Liver	1.8
Lung	3.9
Lymph node	5.8
Ovary	4.4
Pancreas	0.4
Parathyroid gland	5.2
Placenta	5.9
Prostate	3.6
Rectum	4.2
Salivary gland	0.9
Seminal vesicle	3.1
Skeletal muscle	0.3
Skin	8.1
Small intestine	5.2
Smooth muscle	3.3
Spleen	6.2
Stomach	3.3
Testis	8.6
Thyroid gland	5.2
Tonsil	4.3
Urinary bladder	3.8

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
15543602	Underexpression	Chronic Lymphocytic Leukemia	Quantitative expression analysis in 22 B-CLLs revealed significant up-regulation of ARHGAP20 in CLL B cells, whereas BRWD3 was slightly down-regulated.
22024541	Overexpression	Breast Carcinoma	A 1.8-fold increase in BRWD3 was observed while comparing the plasma levels of breast cancer patients (n = 54) with age-matched normal healthy controls (n = 30), and the area under the receiver operating characteristic curve (AUC) was 0.917.

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.185	0.000185	20.8	66.6	12.6	Neutral
BRCA	Breast invasive carcinoma	1075	0.072	0.0178	19.4	67.8	12.7	Neutral
CESC	Cervical and endocervical cancers	292	0.211	0.000283	22.3	65.8	12	Neutral
COAD	Colon adenocarcinoma	449	0.211	6.59e-06	13.6	70.6	15.8	Neutral
ESCA	Esophageal carcinoma	183	0.413	6.15e-09	19.1	54.6	26.2	Neutral
GBM	Glioblastoma multiforme	147	0.068	0.412	24.5	70.1	5.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.082	0.0648	14.8	65.2	20	Neutral
KIRC	Kidney renal clear cell carcinoma	525	-0.029	0.505	9.7	85.9	4.4	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.157	0.00772	10.4	54.5	35.1	Gain
LAML	Acute Myeloid Leukemia	166	-0.02	0.797	4.2	95.2	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	-0.017	0.708	12.9	76.4	10.7	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.111	0.035	20.1	62.4	17.6	Neutral
LUAD	Lung adenocarcinoma	512	0.226	2.37e-07	15	69.9	15	Neutral
LUSC	Lung squamous cell carcinoma	498	0.186	3.05e-05	23.9	59.8	16.3	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.273	1.53e-06	42.3	32.7	25	Loss
PAAD	Pancreatic adenocarcinoma	177	0.022	0.771	11.9	80.2	7.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	-0.094	0.235	30.2	66.7	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	-0.016	0.723	7.5	90	2.4	Neutral
READ	Rectum adenocarcinoma	164	0.195	0.0124	17.7	62.8	19.5	Neutral
SARC	Sarcoma	255	0.242	9.16e-05	40.8	43.5	15.7	Loss
SKCM	Skin Cutaneous Melanoma	367	-0.11	0.0357	24.5	62.1	13.4	Neutral
STAD	Stomach adenocarcinoma	413	0.151	0.0021	12.3	74.3	13.3	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.052	0.529	18	66.7	15.3	Neutral
THCA	Thyroid carcinoma	497	-0.041	0.361	0.8	97.4	1.8	Neutral
THYM	Thymoma	119	-0.023	0.803	5	93.3	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.109	0.0116	13	72.4	14.5	Neutral

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.259	7.04e-08	17	408	0.012	0.888	NS/NA
BRCA	Breast invasive carcinoma	-0.133	8.25e-05	83	785	0.006	0.028	NS/NA
CESC	Cervical and endocervical cancers	-0.127	0.0252	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.213	0.000139	19	297	0.036	0.865	NS/NA
ESCA	Esophageal carcinoma	-0.181	0.0117	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.133	0.291	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.291	5.74e-12	20	522	0.026	0.85	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.055	0.307	24	319	0.043	3.45e-05	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.123	0.0335	23	275	0.07	0.015	NS/NA
LAML	Acute Myeloid Leukemia	-0.034	0.663	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.096	0.0265	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.138	0.00492	41	373	0.039	0.222	NS/NA
LUAD	Lung adenocarcinoma	-0.112	0.0145	21	456	0.085	0.136	NS/NA
LUSC	Lung squamous cell carcinoma	-0.193	0.00016	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.5	0.178	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.113	0.128	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.207	0.00464	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.347	1.6e-16	35	498	0.055	1.71e-08	NS/NA
READ	Rectum adenocarcinoma	-0.124	0.215	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.103	0.0941	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.161	0.000445	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.157	0.00234	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.225	0.00489	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.042	0.322	50	509	-0.065	0.223	NS/NA
THYM	Thymoma	0.091	0.32	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.136	0.00331	34	431	-0.031	3.35e-07	NS/NA

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	1	Low
Cerebral cortex	2	Medium
Cervix, uterine	0	Not detected
Colon	1	Low
Duodenum	1	Low
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	0	Not detected
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	1	Low
Liver	2	Medium
Lung	2	Medium
Lymph node	3	High
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	0	Not detected
Pancreas	2	Medium
Parathyroid gland	0	Not detected
Placenta	2	Medium
Prostate	1	Low
Rectum	0	Not detected
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	1	Low
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	2	Medium
Testis	1	Low
Thyroid gland	1	Low
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	0	Not detected

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.906	NS	24476821
BRCA	Breast invasive carcinoma	521	8.16e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0223	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00254	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00376	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.122	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.94e-08	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.255	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0431	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00441	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.108	NS	26544944
READ	Rectum adenocarcinoma	67	0.396	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0016	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.121	NS	25079317
THCA	Thyroid carcinoma	391	0.981	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.837	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.279	0.257	NS
BRCA	Breast invasive carcinoma	1079	1.589	0.045	Shorter
CESC	Cervical and endocervical cancers	291	1.543	0.243	NS
COAD	Colon adenocarcinoma	439	0.857	0.584	NS
ESCA	Esophageal carcinoma	184	0.976	0.938	NS
GBM	Glioblastoma multiforme	158	0.778	0.327	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.98	0.919	NS
KIRC	Kidney renal clear cell carcinoma	531	0.586	0.018	Longer
KIRP	Kidney renal papillary cell carcinoma	287	2.2	0.0473	Shorter
LAML	Acute Myeloid Leukemia	149	0.622	0.1	NS
LGG	Brain Lower Grade Glioma	511	1.063	0.821	NS
LIHC	Liver hepatocellular carcinoma	365	0.872	0.587	NS
LUAD	Lung adenocarcinoma	502	1.123	0.568	NS
LUSC	Lung squamous cell carcinoma	494	0.924	0.669	NS
OV	Ovarian serous cystadenocarcinoma	303	1.264	0.267	NS
PAAD	Pancreatic adenocarcinoma	177	1.367	0.278	NS
PCPG	Pheochromocytoma and Paraganglioma	179	683528414.054	0.131	NS
PRAD	Prostate adenocarcinoma	497	1350651746.009	0.0251	Shorter
READ	Rectum adenocarcinoma	159	0.661	0.443	NS
SARC	Sarcoma	259	2.172	0.00625	Shorter
SKCM	Skin Cutaneous Melanoma	459	0.749	0.147	NS
STAD	Stomach adenocarcinoma	388	0.568	0.014	Longer
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	1.932	0.584	NS
THYM	Thymoma	119	2.11	0.533	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.232	0.468	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.017	0.739	NS
BRCA	Breast invasive carcinoma	1071	-0.012	0.697	NS
CESC	Cervical and endocervical cancers	167	0.088	0.257	NS
COAD	Colon adenocarcinoma	445	0.009	0.848	NS
ESCA	Esophageal carcinoma	162	-0.017	0.829	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.047	0.322	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.136	0.00164	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.077	0.218	NS
LIHC	Liver hepatocellular carcinoma	347	0.05	0.352	NS
LUAD	Lung adenocarcinoma	507	0.07	0.115	NS
LUSC	Lung squamous cell carcinoma	497	0.086	0.055	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.052	0.371	NS
PAAD	Pancreatic adenocarcinoma	176	0.15	0.0475	Higher
READ	Rectum adenocarcinoma	156	-0.029	0.723	NS
SKCM	Skin Cutaneous Melanoma	410	-0.057	0.252	NS
STAD	Stomach adenocarcinoma	392	0.001	0.991	NS
TGCT	Testicular Germ Cell Tumors	81	0.126	0.264	NS
THCA	Thyroid carcinoma	499	-0.036	0.42	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.014	0.761	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.195	0.00121	Lower
HNSC	Head and Neck squamous cell carcinoma	498	0.012	0.782	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.138	0.0015	Lower
LGG	Brain Lower Grade Glioma	514	0.046	0.296	NS
LIHC	Liver hepatocellular carcinoma	366	-0.019	0.722	NS
OV	Ovarian serous cystadenocarcinoma	296	0	0.993	NS
PAAD	Pancreatic adenocarcinoma	176	0.142	0.0609	NS
STAD	Stomach adenocarcinoma	406	-0.101	0.041	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.054	0.213	NS

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for BRWD3.

Summary
Symbol	BRWD3
Name	bromodomain and WD repeat domain containing 3
Aliases	FLJ38568; MRX93; BRODL; bromo domain-containing protein disrupted in leukemia; novel WD repeat domain protei ......
Location	Xq21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for BRWD3.