CR2Cancer

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF11531 Coactivator-associated arginine methyltransferase 1 N terminal
PF05185 PRMT5 arginine-N-methyltransferase

Function

Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone methylation	H3R17	H3R17me, H3R17me2a	12237300

> Gene Ontology [ TOP ]
Biological Process	GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0001501 skeletal system development GO:0003416 endochondral bone growth GO:0003417 growth plate cartilage development GO:0003419 growth plate cartilage chondrocyte proliferation GO:0003420 regulation of growth plate cartilage chondrocyte proliferation GO:0006479 protein methylation GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007050 cell cycle arrest GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0007568 aging GO:0008213 protein alkylation GO:0009755 hormone-mediated signaling pathway GO:0010721 negative regulation of cell development GO:0010948 negative regulation of cell cycle process GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014074 response to purine-containing compound GO:0016358 dendrite development GO:0016570 histone modification GO:0016571 histone methylation GO:0018195 peptidyl-arginine modification GO:0018216 peptidyl-arginine methylation GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031345 negative regulation of cell projection organization GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0032091 negative regulation of protein binding GO:0032259 methylation GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033146 regulation of intracellular estrogen receptor signaling pathway GO:0034969 histone arginine methylation GO:0034970 histone H3-R2 methylation GO:0034971 histone H3-R17 methylation GO:0035246 peptidyl-arginine N-methylation GO:0035247 peptidyl-arginine omega-N-methylation GO:0035265 organ growth GO:0042770 signal transduction in response to DNA damage GO:0043393 regulation of protein binding GO:0043401 steroid hormone mediated signaling pathway GO:0043414 macromolecule methylation GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045665 negative regulation of neuron differentiation GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0046620 regulation of organ growth GO:0046683 response to organophosphorus GO:0048545 response to steroid hormone GO:0048638 regulation of developmental growth GO:0048705 skeletal system morphogenesis GO:0050768 negative regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051216 cartilage development GO:0051591 response to cAMP GO:0051961 negative regulation of nervous system development GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060350 endochondral bone morphogenesis GO:0060351 cartilage development involved in endochondral bone morphogenesis GO:0061035 regulation of cartilage development GO:0061448 connective tissue development GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:0098868 bone growth GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902415 regulation of mRNA binding GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903010 regulation of bone development GO:1905214 regulation of RNA binding GO:2000027 regulation of organ morphogenesis GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:2000171 negative regulation of dendrite development
Molecular Function	GO:0003713 transcription coactivator activity GO:0008013 beta-catenin binding GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008469 histone-arginine N-methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016273 arginine N-methyltransferase activity GO:0016274 protein-arginine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity GO:0035642 histone methyltransferase activity (H3-R17 specific) GO:0042054 histone methyltransferase activity GO:0042393 histone binding GO:0070577 lysine-acetylated histone binding
Cellular Component	GO:0005667 transcription factor complex GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2426168: Activation of gene expression by SREBF (SREBP) R-HSA-1368108: BMAL1 R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-400253: Circadian Clock R-HSA-1266738: Developmental Biology R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-1989781: PPARA activates gene expression R-HSA-3214858: RMTs methylate histone arginines R-HSA-1368082: RORA activates gene expression R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-2426168: Activation of gene expression by SREBF (SREBP)
R-HSA-1368108: BMAL1
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-400253: Circadian Clock
R-HSA-1266738: Developmental Biology
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-1989781: PPARA activates gene expression
R-HSA-3214858: RMTs methylate histone arginines
R-HSA-1368082: RORA activates gene expression
R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes
R-HSA-6804114: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3712777	c.823G>T	p.A275S	Substitution - Missense	Upper_aerodigestive_tract
COSM145193	c.499G>A	p.V167M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM145193	c.499G>A	p.V167M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1731723	c.1106+1G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM990727	c.1117C>T	p.P373S	Substitution - Missense	Endometrium
COSM417767	c.1775C>A	p.S592Y	Substitution - Missense	Urinary_tract
COSM1611513	c.1449C>G	p.P483P	Substitution - coding silent	Liver
COSM4640177	c.1067C>T	p.T356M	Substitution - Missense	Large_intestine
COSM5921398	c.640G>A	p.E214K	Substitution - Missense	Skin
COSM3388557	c.216C>G	p.Y72*	Substitution - Nonsense	Pancreas
COSM5438154	c.950C>G	p.S317C	Substitution - Missense	Oesophagus
COSM5730344	c.284A>G	p.K95R	Substitution - Missense	Breast
COSM990724	c.333C>T	p.F111F	Substitution - coding silent	Skin
COSM4669282	c.1675_1676insTTGTC	p.Q561fs*>50	Insertion - Frameshift	Large_intestine
COSM2813374	c.1549G>A	p.A517T	Substitution - Missense	Large_intestine
COSM249606	c.978C>G	p.L326L	Substitution - coding silent	Kidney
COSM4383154	c.603T>A	p.F201L	Substitution - Missense	Large_intestine
COSM1325518	c.1021G>A	p.D341N	Substitution - Missense	Ovary
COSM3528391	c.420G>A	p.R140R	Substitution - coding silent	Skin
COSM1579909	c.1355T>C	p.I452T	Substitution - Missense	Central_nervous_system
COSM2813359	c.1088_1090delAAG	p.E364delE	Deletion - In frame	Large_intestine
COSM4669277	c.524C>A	p.A175D	Substitution - Missense	Large_intestine
COSM2813387	c.1802C>T	p.T601I	Substitution - Missense	Large_intestine
COSM338583	c.396G>A	p.L132L	Substitution - coding silent	Lung
COSM5507673	c.86T>A	p.V29E	Substitution - Missense	Biliary_tract
COSM3712777	c.823G>T	p.A275S	Substitution - Missense	Upper_aerodigestive_tract
COSM990728	c.1203C>T	p.T401T	Substitution - coding silent	Endometrium
COSM564791	c.605C>T	p.A202V	Substitution - Missense	Central_nervous_system
COSM5894003	c.650C>T	p.T217I	Substitution - Missense	Skin
COSM1680656	c.254C>T	p.S85F	Substitution - Missense	Ovary
COSM5422379	c.627A>C	p.K209N	Substitution - Missense	Prostate
COSM1611510	c.305T>C	p.L102P	Substitution - Missense	Liver
COSM339354	c.574G>T	p.G192C	Substitution - Missense	Lung
COSM4988295	c.988G>T	p.A330S	Substitution - Missense	Soft_tissue
COSM1238426	c.1462C>A	p.H488N	Substitution - Missense	Oesophagus
COSM3378603	c.257G>A	p.R86Q	Substitution - Missense	Pancreas
COSM3692332	c.1581C>T	p.G527G	Substitution - coding silent	Large_intestine
COSM990726	c.623G>A	p.R208Q	Substitution - Missense	Endometrium
COSM1199586	c.1439C>T	p.T480M	Substitution - Missense	Large_intestine
COSM4669276	c.454delT	p.Y153fs*10	Deletion - Frameshift	Large_intestine
COSM5367953	c.597_598insT	p.A202fs*22	Insertion - Frameshift	Large_intestine
COSM5768779	c.1693G>A	p.G565S	Substitution - Missense	Breast
COSM1641051	c.228_229insTG	p.V77fs*49	Insertion - Frameshift	Stomach
COSM5511013	c.1037G>A	p.R346Q	Substitution - Missense	Biliary_tract
COSM215748	c.796G>A	p.E266K	Substitution - Missense	Central_nervous_system
COSM4441701	c.921C>A	p.F307L	Substitution - Missense	Large_intestine
COSM3403743	c.383G>A	p.R128Q	Substitution - Missense	Central_nervous_system
COSM5620411	c.1445C>T	p.S482L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4669279	c.1478C>T	p.S493L	Substitution - Missense	Large_intestine
COSM3821889	c.1452A>C	p.P484P	Substitution - coding silent	Breast
COSM3528395	c.1382C>T	p.S461F	Substitution - Missense	Skin
COSM4669278	c.661C>T	p.H221Y	Substitution - Missense	Large_intestine
COSM4669275	c.419G>A	p.R140Q	Substitution - Missense	Large_intestine
COSM1303963	c.1583C>G	p.S528C	Substitution - Missense	Urinary_tract
COSM710142	c.1665G>C	p.M555I	Substitution - Missense	Lung
COSM4669280	c.1521C>T	p.S507S	Substitution - coding silent	Large_intestine
COSM990725	c.346G>A	p.D116N	Substitution - Missense	Endometrium
COSM4669283	c.1692C>T	p.S564S	Substitution - coding silent	Large_intestine
COSM3821888	c.608C>T	p.A203V	Substitution - Missense	Breast
COSM5751032	c.1240C>T	p.H414Y	Substitution - Missense	Stomach
COSM6003918	c.343A>G	p.N115D	Substitution - Missense	Prostate
COSM3821890	c.1515C>T	p.L505L	Substitution - coding silent	Breast
COSM2813368	c.1440G>A	p.T480T	Substitution - coding silent	Large_intestine
COSM1611511	c.1020G>T	p.V340V	Substitution - coding silent	Liver
COSM4562142	c.913G>A	p.E305K	Substitution - Missense	Skin
COSM4074002	c.695C>T	p.T232M	Substitution - Missense	Stomach
COSM1390237	c.873C>T	p.D291D	Substitution - coding silent	Large_intestine
COSM1325517	c.1156G>A	p.G386S	Substitution - Missense	Ovary
COSM249606	c.978C>G	p.L326L	Substitution - coding silent	Kidney
COSM4131181	c.44C>T	p.A15V	Substitution - Missense	Thyroid
COSM990724	c.333C>T	p.F111F	Substitution - coding silent	Endometrium
COSM4492856	c.404C>T	p.S135F	Substitution - Missense	Skin
COSM564791	c.605C>T	p.A202V	Substitution - Missense	Skin
COSM4448907	c.1424+1G>A	p.?	Unknown	Skin
COSM5576511	c.1248C>T	p.Y416Y	Substitution - coding silent	Skin
COSM5952118	c.915G>A	p.E305E	Substitution - coding silent	Oesophagus
COSM4508181	c.767C>T	p.S256L	Substitution - Missense	Skin
COSM4771049	c.1628T>C	p.I543T	Substitution - Missense	Pleura
COSM3528391	c.420G>A	p.R140R	Substitution - coding silent	Breast
COSM5894003	c.650C>T	p.T217I	Substitution - Missense	Skin
COSM5794239	c.669+7G>A	p.?	Unknown	Breast
COSM1611510	c.305T>C	p.L102P	Substitution - Missense	Liver
COSM4829433	c.330G>C	p.Q110H	Substitution - Missense	Cervix
COSM3528390	c.227A>T	p.D76V	Substitution - Missense	Skin
COSM3528393	c.609C>T	p.A203A	Substitution - coding silent	Skin
COSM5940835	c.559-7C>T	p.?	Unknown	Skin
COSM4074001	c.561C>T	p.I187I	Substitution - coding silent	Stomach
COSM2813366	c.1408delA	p.N471fs*50	Deletion - Frameshift	Large_intestine
COSM5462789	c.635C>T	p.A212V	Substitution - Missense	Large_intestine
COSM4669281	c.1623G>A	p.T541T	Substitution - coding silent	Large_intestine
COSM1611512	c.1327delA	p.N443fs*27	Deletion - Frameshift	Liver
COSM5817862	c.249A>T	p.S83S	Substitution - coding silent	Liver
COSM3937831	c.568G>C	p.D190H	Substitution - Missense	Oesophagus
COSM2813388	c.1813C>T	p.H605Y	Substitution - Missense	Prostate
COSM1316825	c.1517G>C	p.S506T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM990729	c.1529C>A	p.A510D	Substitution - Missense	Endometrium
COSM1611510	c.305T>C	p.L102P	Substitution - Missense	Liver
COSM5367953	c.597_598insT	p.A202fs*22	Insertion - Frameshift	Large_intestine
COSM4131182	c.1742A>T	p.N581I	Substitution - Missense	Thyroid
COSM4468188	c.1530C>T	p.A510A	Substitution - coding silent	Skin
COSM159748	c.636G>A	p.A212A	Substitution - coding silent	Breast
COSM438513	c.726delG	p.E243fs*37	Deletion - Frameshift	Breast
COSM4455658	c.853A>G	p.M285V	Substitution - Missense	Skin
COSM5056194	c.439G>A	p.V147M	Substitution - Missense	Stomach
COSM385332	c.1721C>T	p.T574M	Substitution - Missense	Lung
COSM2813349	c.692T>C	p.L231P	Substitution - Missense	Large_intestine
COSM2813388	c.1813C>T	p.H605Y	Substitution - Missense	Prostate
COSM5683138	c.1349T>A	p.I450N	Substitution - Missense	Soft_tissue
COSM2813352	c.778G>T	p.G260C	Substitution - Missense	Large_intestine
COSM1611513	c.1449C>G	p.P483P	Substitution - coding silent	Liver
COSM3528394	c.762C>T	p.I254I	Substitution - coding silent	Skin
COSM2813361	c.1281C>T	p.F427F	Substitution - coding silent	Large_intestine
COSM4074004	c.1707T>C	p.S569S	Substitution - coding silent	Stomach
COSM3821891	c.1560G>C	p.L520F	Substitution - Missense	Breast
COSM4074003	c.1675A>G	p.I559V	Substitution - Missense	Stomach
COSM5056195	c.1061A>G	p.K354R	Substitution - Missense	Stomach
COSM564791	c.605C>T	p.A202V	Substitution - Missense	Skin
COSM2813374	c.1549G>A	p.A517T	Substitution - Missense	Upper_aerodigestive_tract
COSM3989659	c.531G>A	p.L177L	Substitution - coding silent	Kidney
COSM3528396	c.1388C>T	p.S463F	Substitution - Missense	Skin
COSM2813365	c.1343A>G	p.Y448C	Substitution - Missense	Large_intestine
COSM4074005	c.1819G>A	p.G607R	Substitution - Missense	Stomach
COSM1325519	c.630C>G	p.I210M	Substitution - Missense	Ovary
COSM3528392	c.450C>T	p.F150F	Substitution - coding silent	Skin
COSM990730	c.1825T>C	p.*609Q	Nonstop extension	Endometrium
COSM5365092	c.1202C>T	p.T401I	Substitution - Missense	Large_intestine
COSM5936439	c.859C>T	p.P287S	Substitution - Missense	Skin
COSM2813388	c.1813C>T	p.H605Y	Substitution - Missense	Prostate
COSM1303962	c.1350C>T	p.I450I	Substitution - coding silent	Urinary_tract
COSM1189880	c.701G>C	p.R234P	Substitution - Missense	Lung
COSM1480539	c.950C>T	p.S317F	Substitution - Missense	Breast
COSM990724	c.333C>T	p.F111F	Substitution - coding silent	Breast
COSM1303961	c.424G>A	p.E142K	Substitution - Missense	Urinary_tract

> Text Mining based Variations [ TOP ]
There is no record for CARM1.

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q86X55	216	S	Phosphoserine	-	No	None detected
Q86X55	550	R	Dimethylated arginine	-	No	None detected

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.935	6.346	0.37	0.00109	NS
BRCA	Breast invasive carcinoma	112	1100	5.237	5.922	0.698	1.19e-41	Over
CESC	Cervical and endocervical cancers	3	306	6.148	6.259	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.374	6.814	0.477	4.62e-09	NS
ESCA	Esophageal carcinoma	11	185	5.91	6.826	0.657	0.00059	Over
GBM	Glioblastoma multiforme	5	166	6.09	5.891	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.312	6.335	0.023	0.776	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.477	5.363	-0.094	0.0694	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.754	5.826	0.107	0.142	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.565	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.375	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.917	5.318	0.369	5.48e-07	NS
LUAD	Lung adenocarcinoma	59	517	5.184	5.724	0.51	5.38e-16	NS
LUSC	Lung squamous cell carcinoma	51	501	5.241	6.322	1.086	1.82e-36	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.084	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.877	5.883	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.473	5.702	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.704	5.973	0.262	1.76e-08	NS
READ	Rectum adenocarcinoma	10	167	6.148	6.899	0.74	5.09e-05	Over
SARC	Sarcoma	2	263	5.852	6.463	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.989	6.436	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.585	6.686	0.08	0.446	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.628	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.103	5.426	0.345	3.01e-12	NS
THYM	Thymoma	2	120	5.46	5.632	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.372	6.944	0.716	4.33e-13	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.8
Autonomic ganglia	CHP212	9
Autonomic ganglia	IMR32	8.8
Autonomic ganglia	KELLY	8.3
Autonomic ganglia	KPNRTBM1	9.4
Autonomic ganglia	KPNSI9S	8.5
Autonomic ganglia	KPNYN	8.6
Autonomic ganglia	MHHNB11	9.1
Autonomic ganglia	NB1	9.4
Autonomic ganglia	NH6	8.6
Autonomic ganglia	SHSY5Y	8.9
Autonomic ganglia	SIMA	9.3
Autonomic ganglia	SKNAS	9.1
Autonomic ganglia	SKNBE2	8.9
Autonomic ganglia	SKNDZ	8.5
Autonomic ganglia	SKNFI	7.6
Autonomic ganglia	SKNSH	8.7
Biliary tract	HUCCT1	8.5
Biliary tract	HUH28	8.7
Biliary tract	SNU1079	8.7
Biliary tract	SNU1196	8.5
Biliary tract	SNU245	8.7
Biliary tract	SNU308	8.2
Biliary tract	SNU478	9.3
Bone	143B	8.7
Bone	A673	9.2
Bone	CADOES1	9
Bone	CAL78	8.2
Bone	G292CLONEA141B1	9.5
Bone	HOS	7.9
Bone	HS706T	8.3
Bone	HS737T	9
Bone	HS819T	8.9
Bone	HS821T	8.4
Bone	HS822T	8.7
Bone	HS863T	9
Bone	HS870T	8.4
Bone	HS888T	9.3
Bone	MG63	9.8
Bone	MHHES1	9.1
Bone	OUMS27	8.8
Bone	RDES	9.2
Bone	SJSA1	8.4
Bone	SKES1	9.4
Bone	SKNMC	9.4
Bone	SW1353	8.9
Bone	T173	8.6
Bone	TC71	9.2
Bone	U2OS	8.9
Breast	AU565	8.1
Breast	BT20	8.2
Breast	BT474	9.1
Breast	BT483	7.7
Breast	BT549	9.4
Breast	CAL120	9.2
Breast	CAL148	8.7
Breast	CAL51	9.1
Breast	CAL851	8.9
Breast	CAMA1	8.4
Breast	DU4475	7.2
Breast	EFM192A	8
Breast	EFM19	8.9
Breast	EVSAT	9
Breast	HCC1143	8
Breast	HCC1187	9.9
Breast	HCC1395	8.7
Breast	HCC1419	8.5
Breast	HCC1428	8.1
Breast	HCC1500	8
Breast	HCC1569	9.3
Breast	HCC1599	8.8
Breast	HCC1806	8.9
Breast	HCC1937	8.6
Breast	HCC1954	8.6
Breast	HCC202	8.2
Breast	HCC2157	8.8
Breast	HCC2218	8.8
Breast	HCC38	8.4
Breast	HCC70	8.3
Breast	HDQP1	9.2
Breast	HMC18	8.9
Breast	HS274T	8.9
Breast	HS281T	9.2
Breast	HS343T	9.2
Breast	HS578T	9.2
Breast	HS606T	8.9
Breast	HS739T	8.5
Breast	HS742T	8.3
Breast	JIMT1	9
Breast	KPL1	9.4
Breast	MCF7	9
Breast	MDAMB134VI	7.4
Breast	MDAMB157	8.1
Breast	MDAMB175VII	8.4
Breast	MDAMB231	9
Breast	MDAMB361	8.7
Breast	MDAMB415	7.7
Breast	MDAMB436	8.6
Breast	MDAMB453	7.9
Breast	MDAMB468	9.1
Breast	SKBR3	8.7
Breast	T47D	7.7
Breast	UACC812	8.9
Breast	UACC893	8.7
Breast	YMB1	8.5
Breast	ZR751	7.6
Breast	ZR7530	8
Central nervous system	1321N1	9.1
Central nervous system	42MGBA	8.9
Central nervous system	8MGBA	7.9
Central nervous system	A172	9.4
Central nervous system	AM38	9.3
Central nervous system	BECKER	8.9
Central nervous system	CAS1	9
Central nervous system	CCFSTTG1	8.9
Central nervous system	D283MED	8.8
Central nervous system	D341MED	8.6
Central nervous system	DAOY	8.5
Central nervous system	DBTRG05MG	8.9
Central nervous system	DKMG	8
Central nervous system	GAMG	8.1
Central nervous system	GB1	9.8
Central nervous system	GI1	9.6
Central nervous system	GMS10	7.6
Central nervous system	GOS3	8.8
Central nervous system	H4	9
Central nervous system	HS683	8.5
Central nervous system	KALS1	8.5
Central nervous system	KG1C	8.5
Central nervous system	KNS42	8.5
Central nervous system	KNS60	8
Central nervous system	KNS81	8.9
Central nervous system	KS1	8.9
Central nervous system	LN18	8.6
Central nervous system	LN229	8
Central nervous system	M059K	8.9
Central nervous system	MOGGCCM	8.9
Central nervous system	MOGGUVW	8.9
Central nervous system	NMCG1	8.8
Central nervous system	ONS76	9.1
Central nervous system	SF126	8.6
Central nervous system	SF295	9.5
Central nervous system	SNB19	7.8
Central nervous system	SNU1105	8.7
Central nervous system	SNU201	8.6
Central nervous system	SNU466	8.7
Central nervous system	SNU489	10.1
Central nervous system	SNU626	7.6
Central nervous system	SNU738	8.1
Central nervous system	SW1088	8.8
Central nervous system	SW1783	8.9
Central nervous system	T98G	8.3
Central nervous system	TM31	8.3
Central nervous system	U118MG	10.2
Central nervous system	U138MG	9.8
Central nervous system	U251MG	8.2
Central nervous system	U87MG	9.3
Central nervous system	YH13	9
Central nervous system	YKG1	8.4
Endometrium	AN3CA	10
Endometrium	COLO684	10
Endometrium	EFE184	9.9
Endometrium	EN	9
Endometrium	ESS1	8.4
Endometrium	HEC108	8.7
Endometrium	HEC151	8.6
Endometrium	HEC1A	9.2
Endometrium	HEC1B	9.1
Endometrium	HEC251	8.1
Endometrium	HEC265	8.8
Endometrium	HEC50B	8.9
Endometrium	HEC59	8.8
Endometrium	HEC6	8.5
Endometrium	ISHIKAWAHERAKLIO02ER	8.1
Endometrium	JHUEM1	9.8
Endometrium	JHUEM2	9.3
Endometrium	JHUEM3	8.9
Endometrium	KLE	8.3
Endometrium	MFE280	8.1
Endometrium	MFE296	9.6
Endometrium	MFE319	8.3
Endometrium	RL952	9.5
Endometrium	SNGM	9.3
Endometrium	SNU1077	8.7
Endometrium	SNU685	10
Endometrium	TEN	8.8
Haematopoietic and lymphoid	697	9.4
Haematopoietic and lymphoid	A3KAW	9.1
Haematopoietic and lymphoid	A4FUK	8.9
Haematopoietic and lymphoid	ALLSIL	8.7
Haematopoietic and lymphoid	AML193	7.7
Haematopoietic and lymphoid	AMO1	9.2
Haematopoietic and lymphoid	BCP1	8.8
Haematopoietic and lymphoid	BDCM	9.3
Haematopoietic and lymphoid	BL41	9.3
Haematopoietic and lymphoid	BL70	9.8
Haematopoietic and lymphoid	BV173	9.5
Haematopoietic and lymphoid	CA46	9.1
Haematopoietic and lymphoid	CI1	9.8
Haematopoietic and lymphoid	CMK115	8.7
Haematopoietic and lymphoid	CMK86	9.6
Haematopoietic and lymphoid	CMK	8.4
Haematopoietic and lymphoid	CMLT1	8.3
Haematopoietic and lymphoid	COLO775	9.9
Haematopoietic and lymphoid	DAUDI	9.5
Haematopoietic and lymphoid	DB	10.5
Haematopoietic and lymphoid	DEL	9.1
Haematopoietic and lymphoid	DND41	8.9
Haematopoietic and lymphoid	DOHH2	9.2
Haematopoietic and lymphoid	EB1	10
Haematopoietic and lymphoid	EB2	9.9
Haematopoietic and lymphoid	EHEB	9.8
Haematopoietic and lymphoid	EJM	8.8
Haematopoietic and lymphoid	EM2	8.5
Haematopoietic and lymphoid	EOL1	8.8
Haematopoietic and lymphoid	F36P	9.9
Haematopoietic and lymphoid	GA10	9.6
Haematopoietic and lymphoid	GDM1	7.7
Haematopoietic and lymphoid	GRANTA519	9.1
Haematopoietic and lymphoid	HDLM2	9.6
Haematopoietic and lymphoid	HDMYZ	9.5
Haematopoietic and lymphoid	HEL9217	8.4
Haematopoietic and lymphoid	HEL	8.8
Haematopoietic and lymphoid	HH	10.4
Haematopoietic and lymphoid	HL60	9.5
Haematopoietic and lymphoid	HPBALL	8.7
Haematopoietic and lymphoid	HS604T	8.6
Haematopoietic and lymphoid	HS611T	8.9
Haematopoietic and lymphoid	HS616T	8.8
Haematopoietic and lymphoid	HS751T	7.9
Haematopoietic and lymphoid	HT	9.3
Haematopoietic and lymphoid	HTK	9.8
Haematopoietic and lymphoid	HUNS1	9.9
Haematopoietic and lymphoid	HUT102	8.3
Haematopoietic and lymphoid	HUT78	7.6
Haematopoietic and lymphoid	JEKO1	9.9
Haematopoietic and lymphoid	JK1	8.3
Haematopoietic and lymphoid	JM1	8.6
Haematopoietic and lymphoid	JURKAT	9.1
Haematopoietic and lymphoid	JURLMK1	9
Haematopoietic and lymphoid	JVM2	10.2
Haematopoietic and lymphoid	JVM3	9.9
Haematopoietic and lymphoid	K562	9.6
Haematopoietic and lymphoid	KARPAS299	9
Haematopoietic and lymphoid	KARPAS422	8.9
Haematopoietic and lymphoid	KARPAS620	9.2
Haematopoietic and lymphoid	KASUMI1	7.8
Haematopoietic and lymphoid	KASUMI2	8.9
Haematopoietic and lymphoid	KASUMI6	7.8
Haematopoietic and lymphoid	KCL22	8.9
Haematopoietic and lymphoid	KE37	8.2
Haematopoietic and lymphoid	KE97	9
Haematopoietic and lymphoid	KG1	8.6
Haematopoietic and lymphoid	KHM1B	9.1
Haematopoietic and lymphoid	KIJK	9.3
Haematopoietic and lymphoid	KMH2	9.7
Haematopoietic and lymphoid	KMM1	8.9
Haematopoietic and lymphoid	KMS11	8.6
Haematopoietic and lymphoid	KMS12BM	8.8
Haematopoietic and lymphoid	KMS18	9.4
Haematopoietic and lymphoid	KMS20	9
Haematopoietic and lymphoid	KMS21BM	8.5
Haematopoietic and lymphoid	KMS26	8.3
Haematopoietic and lymphoid	KMS27	9.3
Haematopoietic and lymphoid	KMS28BM	8.3
Haematopoietic and lymphoid	KMS34	9.1
Haematopoietic and lymphoid	KO52	7.5
Haematopoietic and lymphoid	KOPN8	10.1
Haematopoietic and lymphoid	KU812	9.3
Haematopoietic and lymphoid	KYO1	8.9
Haematopoietic and lymphoid	L1236	9.2
Haematopoietic and lymphoid	L363	9.4
Haematopoietic and lymphoid	L428	9.4
Haematopoietic and lymphoid	L540	8.9
Haematopoietic and lymphoid	LAMA84	8.5
Haematopoietic and lymphoid	LOUCY	7.9
Haematopoietic and lymphoid	LP1	8.4
Haematopoietic and lymphoid	M07E	8.8
Haematopoietic and lymphoid	MC116	9.8
Haematopoietic and lymphoid	ME1	8.7
Haematopoietic and lymphoid	MEC1	8.3
Haematopoietic and lymphoid	MEC2	9.8
Haematopoietic and lymphoid	MEG01	10
Haematopoietic and lymphoid	MHHCALL2	8.5
Haematopoietic and lymphoid	MHHCALL3	8.7
Haematopoietic and lymphoid	MHHCALL4	8.6
Haematopoietic and lymphoid	MINO	9.2
Haematopoietic and lymphoid	MJ	9.9
Haematopoietic and lymphoid	MM1S	8.7
Haematopoietic and lymphoid	MOLM13	9.4
Haematopoietic and lymphoid	MOLM16	11.1
Haematopoietic and lymphoid	MOLM6	8.7
Haematopoietic and lymphoid	MOLP2	9.3
Haematopoietic and lymphoid	MOLP8	7.7
Haematopoietic and lymphoid	MOLT13	8.2
Haematopoietic and lymphoid	MOLT16	8
Haematopoietic and lymphoid	MOLT4	8.4
Haematopoietic and lymphoid	MONOMAC1	8.2
Haematopoietic and lymphoid	MONOMAC6	8.7
Haematopoietic and lymphoid	MOTN1	8.9
Haematopoietic and lymphoid	MUTZ5	9
Haematopoietic and lymphoid	MV411	10
Haematopoietic and lymphoid	NALM19	8.9
Haematopoietic and lymphoid	NALM1	8.7
Haematopoietic and lymphoid	NALM6	8.6
Haematopoietic and lymphoid	NAMALWA	10.5
Haematopoietic and lymphoid	NB4	8.7
Haematopoietic and lymphoid	NCIH929	8.6
Haematopoietic and lymphoid	NCO2	9
Haematopoietic and lymphoid	NOMO1	8.5
Haematopoietic and lymphoid	NUDHL1	10.2
Haematopoietic and lymphoid	NUDUL1	9.1
Haematopoietic and lymphoid	OCIAML2	8
Haematopoietic and lymphoid	OCIAML3	8.8
Haematopoietic and lymphoid	OCIAML5	9
Haematopoietic and lymphoid	OCILY10	9.6
Haematopoietic and lymphoid	OCILY19	9.7
Haematopoietic and lymphoid	OCILY3	9.3
Haematopoietic and lymphoid	OCIM1	10
Haematopoietic and lymphoid	OPM2	8.7
Haematopoietic and lymphoid	P12ICHIKAWA	8.5
Haematopoietic and lymphoid	P31FUJ	8.6
Haematopoietic and lymphoid	P3HR1	8.8
Haematopoietic and lymphoid	PCM6	9.6
Haematopoietic and lymphoid	PEER	9.2
Haematopoietic and lymphoid	PF382	8.2
Haematopoietic and lymphoid	PFEIFFER	9.1
Haematopoietic and lymphoid	PL21	8.2
Haematopoietic and lymphoid	RAJI	9.8
Haematopoietic and lymphoid	RCHACV	8.9
Haematopoietic and lymphoid	REC1	9.9
Haematopoietic and lymphoid	REH	9.4
Haematopoietic and lymphoid	RI1	9.6
Haematopoietic and lymphoid	RL	9.3
Haematopoietic and lymphoid	RPMI8226	9.1
Haematopoietic and lymphoid	RPMI8402	9.1
Haematopoietic and lymphoid	RS411	9.3
Haematopoietic and lymphoid	SEM	8.2
Haematopoietic and lymphoid	SET2	9
Haematopoietic and lymphoid	SIGM5	8.4
Haematopoietic and lymphoid	SKM1	8.7
Haematopoietic and lymphoid	SKMM2	8.4
Haematopoietic and lymphoid	SR786	8.8
Haematopoietic and lymphoid	ST486	9.3
Haematopoietic and lymphoid	SUDHL10	9.9
Haematopoietic and lymphoid	SUDHL1	9.5
Haematopoietic and lymphoid	SUDHL4	10.4
Haematopoietic and lymphoid	SUDHL5	9.7
Haematopoietic and lymphoid	SUDHL6	9.1
Haematopoietic and lymphoid	SUDHL8	9.4
Haematopoietic and lymphoid	SUPB15	8.9
Haematopoietic and lymphoid	SUPHD1	9.6
Haematopoietic and lymphoid	SUPM2	9.1
Haematopoietic and lymphoid	SUPT11	8.7
Haematopoietic and lymphoid	SUPT1	8.4
Haematopoietic and lymphoid	TALL1	8.2
Haematopoietic and lymphoid	TF1	9.4
Haematopoietic and lymphoid	THP1	8
Haematopoietic and lymphoid	TO175T	9
Haematopoietic and lymphoid	TOLEDO	8.4
Haematopoietic and lymphoid	U266B1	8.8
Haematopoietic and lymphoid	U937	9.4
Haematopoietic and lymphoid	UT7	9.4
Haematopoietic and lymphoid	WSUDLCL2	9.5
Kidney	769P	8.8
Kidney	786O	9.3
Kidney	A498	8.9
Kidney	A704	7
Kidney	ACHN	8.7
Kidney	BFTC909	8.8
Kidney	CAKI1	7.9
Kidney	CAKI2	8.9
Kidney	CAL54	8.6
Kidney	KMRC1	8
Kidney	KMRC20	7.7
Kidney	KMRC2	8.9
Kidney	KMRC3	8.5
Kidney	OSRC2	8.4
Kidney	RCC10RGB	9
Kidney	SNU1272	9.1
Kidney	SNU349	9.3
Kidney	TUHR10TKB	8.3
Kidney	TUHR14TKB	8.7
Kidney	TUHR4TKB	8.3
Kidney	VMRCRCW	8.9
Kidney	VMRCRCZ	8.8
Large intestine	C2BBE1	9.4
Large intestine	CCK81	9.5
Large intestine	CL11	9.4
Large intestine	CL14	9.4
Large intestine	CL34	9.3
Large intestine	CL40	9.2
Large intestine	COLO205	8.8
Large intestine	COLO320	9.2
Large intestine	COLO678	8.5
Large intestine	CW2	9.3
Large intestine	DLD1	9.6
Large intestine	GP2D	9.3
Large intestine	HCC56	9.6
Large intestine	HCT116	9.9
Large intestine	HCT15	10.4
Large intestine	HS675T	8.9
Large intestine	HS698T	8.6
Large intestine	HT115	9.5
Large intestine	HT29	9.2
Large intestine	HT55	9.1
Large intestine	KM12	8.8
Large intestine	LOVO	8.7
Large intestine	LS1034	9.4
Large intestine	LS123	8.7
Large intestine	LS180	9.6
Large intestine	LS411N	9
Large intestine	LS513	8.1
Large intestine	MDST8	9.2
Large intestine	NCIH508	8.9
Large intestine	NCIH716	8.4
Large intestine	NCIH747	8.4
Large intestine	OUMS23	8.2
Large intestine	RCM1	8.6
Large intestine	RKO	8.8
Large intestine	SKCO1	8.9
Large intestine	SNU1040	9.3
Large intestine	SNU1197	8.4
Large intestine	SNU175	8.9
Large intestine	SNU283	9.2
Large intestine	SNU407	9.1
Large intestine	SNU503	8.7
Large intestine	SNU61	9.3
Large intestine	SNU81	9.5
Large intestine	SNUC1	9.3
Large intestine	SNUC2A	7.9
Large intestine	SNUC4	9.7
Large intestine	SNUC5	9.1
Large intestine	SW1116	8.8
Large intestine	SW1417	9
Large intestine	SW1463	9.9
Large intestine	SW403	9
Large intestine	SW480	7.7
Large intestine	SW48	9.9
Large intestine	SW620	9.4
Large intestine	SW837	7.4
Large intestine	SW948	9.3
Large intestine	T84	9.8
Liver	ALEXANDERCELLS	7.9
Liver	C3A	8.6
Liver	HEP3B217	8.5
Liver	HEPG2	9
Liver	HLE	7.7
Liver	HLF	8.6
Liver	HUH1	8.9
Liver	HUH6	8.8
Liver	HUH7	8.3
Liver	JHH1	9
Liver	JHH2	9.9
Liver	JHH4	8.7
Liver	JHH5	9
Liver	JHH6	8
Liver	JHH7	9.1
Liver	LI7	8.3
Liver	PLCPRF5	8.5
Liver	SKHEP1	8.1
Liver	SNU182	9.2
Liver	SNU387	8.4
Liver	SNU398	9.5
Liver	SNU423	9
Liver	SNU449	8.5
Liver	SNU475	8.3
Liver	SNU761	8.8
Liver	SNU878	7
Liver	SNU886	9.4
Lung	A549	8.3
Lung	ABC1	8.9
Lung	BEN	8
Lung	CAL12T	8.3
Lung	CALU1	9.3
Lung	CALU3	7.6
Lung	CALU6	8.4
Lung	CHAGOK1	7.6
Lung	COLO668	7.7
Lung	COLO699	8.9
Lung	CORL105	9
Lung	CORL23	9.1
Lung	CORL24	7.3
Lung	CORL279	10.2
Lung	CORL311	9
Lung	CORL47	7.3
Lung	CORL51	8.1
Lung	CORL88	7.1
Lung	CORL95	7.4
Lung	CPCN	8.3
Lung	DMS114	8.5
Lung	DMS153	7.4
Lung	DMS273	9.7
Lung	DMS454	7.1
Lung	DMS53	7.3
Lung	DMS79	8.1
Lung	DV90	9.1
Lung	EBC1	7.5
Lung	EPLC272H	9.1
Lung	HARA	9.3
Lung	HCC1171	7.9
Lung	HCC1195	7.8
Lung	HCC15	7.8
Lung	HCC2279	9.5
Lung	HCC2935	8.6
Lung	HCC33	8.2
Lung	HCC366	7.8
Lung	HCC4006	7.4
Lung	HCC44	8.4
Lung	HCC78	8.3
Lung	HCC827	8.9
Lung	HCC95	8.1
Lung	HLC1	9.1
Lung	HLFA	8.9
Lung	HS229T	8.9
Lung	HS618T	8.9
Lung	IALM	8.6
Lung	KNS62	8.5
Lung	LC1F	9
Lung	LC1SQSF	8.1
Lung	LCLC103H	8.7
Lung	LCLC97TM1	8.2
Lung	LK2	8.8
Lung	LOUNH91	9.3
Lung	LU65	8.6
Lung	LU99	8.3
Lung	LUDLU1	8.6
Lung	LXF289	8.5
Lung	MORCPR	9.3
Lung	NCIH1048	8.8
Lung	NCIH1092	7.3
Lung	NCIH1105	7.6
Lung	NCIH1155	8.1
Lung	NCIH1184	7.2
Lung	NCIH1299	10
Lung	NCIH1339	8
Lung	NCIH1341	9
Lung	NCIH1355	8.1
Lung	NCIH1373	8
Lung	NCIH1385	7.1
Lung	NCIH1395	8
Lung	NCIH1435	8.1
Lung	NCIH1436	8
Lung	NCIH1437	8.4
Lung	NCIH146	7.9
Lung	NCIH1563	8.6
Lung	NCIH1568	8.2
Lung	NCIH1573	7.7
Lung	NCIH1581	8.4
Lung	NCIH1618	8.7
Lung	NCIH1623	8.2
Lung	NCIH1648	8.3
Lung	NCIH1650	8.6
Lung	NCIH1651	7.6
Lung	NCIH1666	8.2
Lung	NCIH1693	7.6
Lung	NCIH1694	7.7
Lung	NCIH1703	8.8
Lung	NCIH1734	7.8
Lung	NCIH1755	8.6
Lung	NCIH1781	8.4
Lung	NCIH1792	9.3
Lung	NCIH1793	8.9
Lung	NCIH1836	8.1
Lung	NCIH1838	8.2
Lung	NCIH1869	6.9
Lung	NCIH1876	7.6
Lung	NCIH1915	8.3
Lung	NCIH1930	8.7
Lung	NCIH1944	7
Lung	NCIH1963	9.1
Lung	NCIH196	8.3
Lung	NCIH1975	9.5
Lung	NCIH2009	8.4
Lung	NCIH2023	8.2
Lung	NCIH2029	8.3
Lung	NCIH2030	8.7
Lung	NCIH2066	7.8
Lung	NCIH2081	7.5
Lung	NCIH2085	7.8
Lung	NCIH2087	7.1
Lung	NCIH209	8.7
Lung	NCIH2106	7.4
Lung	NCIH2110	8.2
Lung	NCIH211	8.9
Lung	NCIH2122	8.6
Lung	NCIH2126	8.2
Lung	NCIH2141	8
Lung	NCIH2170	9.3
Lung	NCIH2171	8.3
Lung	NCIH2172	7.4
Lung	NCIH2196	8.5
Lung	NCIH2227	8.4
Lung	NCIH2228	8.7
Lung	NCIH226	8.5
Lung	NCIH2286	8.8
Lung	NCIH2291	8.5
Lung	NCIH2342	8
Lung	NCIH2347	7.8
Lung	NCIH23	8.5
Lung	NCIH2405	8.2
Lung	NCIH2444	8.4
Lung	NCIH292	9.2
Lung	NCIH322	8.2
Lung	NCIH3255	9.5
Lung	NCIH358	8.5
Lung	NCIH441	8
Lung	NCIH446	9.4
Lung	NCIH460	9.3
Lung	NCIH510	8.2
Lung	NCIH520	9.7
Lung	NCIH522	8.8
Lung	NCIH524	9.8
Lung	NCIH526	9.2
Lung	NCIH596	7.4
Lung	NCIH647	7.6
Lung	NCIH650	7.9
Lung	NCIH661	8.1
Lung	NCIH69	9
Lung	NCIH727	8.9
Lung	NCIH810	8.5
Lung	NCIH82	9.2
Lung	NCIH838	8.2
Lung	NCIH841	9.1
Lung	NCIH854	8.6
Lung	NCIH889	7.5
Lung	PC14	9.2
Lung	RERFLCAD1	7.9
Lung	RERFLCAD2	7.9
Lung	RERFLCAI	8.7
Lung	RERFLCKJ	7.1
Lung	RERFLCMS	8.3
Lung	RERFLCSQ1	8.6
Lung	SBC5	9.1
Lung	SCLC21H	9
Lung	SHP77	8.2
Lung	SKLU1	9
Lung	SKMES1	8
Lung	SQ1	8.8
Lung	SW1271	8.6
Lung	SW1573	8
Lung	SW900	7.9
Lung	VMRCLCD	9.4
Lung	VMRCLCP	8.8
Oesophagus	COLO680N	7.8
Oesophagus	ECGI10	8
Oesophagus	KYSE140	10.3
Oesophagus	KYSE150	9.1
Oesophagus	KYSE180	9.6
Oesophagus	KYSE270	10
Oesophagus	KYSE30	9.2
Oesophagus	KYSE410	9.1
Oesophagus	KYSE450	8.7
Oesophagus	KYSE510	9.2
Oesophagus	KYSE520	8.8
Oesophagus	KYSE70	9.1
Oesophagus	OE19	8.9
Oesophagus	OE33	7.5
Oesophagus	TE10	9
Oesophagus	TE11	8.8
Oesophagus	TE14	8.7
Oesophagus	TE15	8.5
Oesophagus	TE1	7.8
Oesophagus	TE4	8.9
Oesophagus	TE5	8.6
Oesophagus	TE6	8.6
Oesophagus	TE8	9.2
Oesophagus	TE9	8.8
Oesophagus	TT	9.1
Ovary	59M	10.2
Ovary	A2780	9.7
Ovary	CAOV3	8.3
Ovary	CAOV4	7.2
Ovary	COLO704	9.1
Ovary	COV318	8.7
Ovary	COV362	7.3
Ovary	COV434	8.6
Ovary	COV504	7.9
Ovary	COV644	7.3
Ovary	EFO21	9.3
Ovary	EFO27	9.4
Ovary	ES2	9.1
Ovary	FUOV1	8.7
Ovary	HEYA8	8.7
Ovary	HS571T	8.7
Ovary	IGROV1	9.7
Ovary	JHOC5	8.5
Ovary	JHOM1	8.1
Ovary	JHOM2B	8.7
Ovary	JHOS2	7.5
Ovary	JHOS4	7.5
Ovary	KURAMOCHI	9
Ovary	MCAS	8.5
Ovary	NIHOVCAR3	7.8
Ovary	OAW28	8.9
Ovary	OAW42	9.2
Ovary	OC314	9.5
Ovary	OC316	9
Ovary	ONCODG1	7.7
Ovary	OV56	8.5
Ovary	OV7	8.9
Ovary	OV90	9.5
Ovary	OVCAR4	9.5
Ovary	OVCAR8	8.6
Ovary	OVISE	9.3
Ovary	OVK18	9.7
Ovary	OVKATE	7.5
Ovary	OVMANA	7.5
Ovary	OVSAHO	9.3
Ovary	OVTOKO	8.8
Ovary	RMGI	9
Ovary	RMUGS	7.5
Ovary	SKOV3	9.3
Ovary	SNU119	8.1
Ovary	SNU840	8.1
Ovary	SNU8	7.9
Ovary	TOV112D	9.8
Ovary	TOV21G	9.3
Ovary	TYKNU	8.8
Pancreas	ASPC1	8.7
Pancreas	BXPC3	8.5
Pancreas	CAPAN1	8.3
Pancreas	CAPAN2	7.5
Pancreas	CFPAC1	7.5
Pancreas	DANG	9.4
Pancreas	HPAC	7.9
Pancreas	HPAFII	8.8
Pancreas	HS766T	8.7
Pancreas	HUPT3	9.7
Pancreas	HUPT4	8.6
Pancreas	KCIMOH1	7.2
Pancreas	KLM1	9
Pancreas	KP2	7.8
Pancreas	KP3	7.6
Pancreas	KP4	8.9
Pancreas	L33	8.4
Pancreas	MIAPACA2	10.4
Pancreas	PANC0203	7.8
Pancreas	PANC0213	8.2
Pancreas	PANC0327	8.6
Pancreas	PANC0403	7.9
Pancreas	PANC0504	8.5
Pancreas	PANC0813	8.3
Pancreas	PANC1005	8.2
Pancreas	PANC1	8
Pancreas	PATU8902	8.9
Pancreas	PATU8988S	8.3
Pancreas	PATU8988T	9.8
Pancreas	PK1	8
Pancreas	PK45H	8
Pancreas	PK59	8.5
Pancreas	PL45	7.8
Pancreas	PSN1	9.6
Pancreas	QGP1	8.7
Pancreas	SNU213	8
Pancreas	SNU324	8.7
Pancreas	SNU410	8.7
Pancreas	SU8686	8.4
Pancreas	SUIT2	8.1
Pancreas	SW1990	8.6
Pancreas	T3M4	7.3
Pancreas	TCCPAN2	9.4
Pancreas	YAPC	8.6
Pleura	ACCMESO1	7.7
Pleura	DM3	9.3
Pleura	ISTMES1	9.4
Pleura	ISTMES2	8
Pleura	JL1	9.3
Pleura	MPP89	8.4
Pleura	MSTO211H	9.1
Pleura	NCIH2052	9.3
Pleura	NCIH2452	8.6
Pleura	NCIH28	8.6
Prostate	22RV1	8.7
Prostate	DU145	9.2
Prostate	LNCAPCLONEFGC	7.6
Prostate	MDAPCA2B	9
Prostate	NCIH660	7.7
Prostate	PC3	9.6
Prostate	VCAP	7.2
Salivary gland	A253	8.4
Salivary gland	YD15	8.8
Skin	A101D	8.6
Skin	A2058	9.6
Skin	A375	10.2
Skin	C32	8
Skin	CHL1	8.9
Skin	CJM	8.3
Skin	COLO679	8.6
Skin	COLO741	8.9
Skin	COLO783	8.4
Skin	COLO792	7.8
Skin	COLO800	8.5
Skin	COLO818	7.7
Skin	COLO829	8.9
Skin	COLO849	9.9
Skin	G361	8.7
Skin	GRM	10.7
Skin	HMCB	8.9
Skin	HS294T	9.3
Skin	HS600T	8.8
Skin	HS688AT	9
Skin	HS695T	7.8
Skin	HS839T	9.5
Skin	HS852T	8.7
Skin	HS895T	8.4
Skin	HS934T	9
Skin	HS936T	8.2
Skin	HS939T	8.3
Skin	HS940T	8.5
Skin	HS944T	8.7
Skin	HT144	8.4
Skin	IGR1	8.7
Skin	IGR37	9.9
Skin	IGR39	8.9
Skin	IPC298	8.8
Skin	K029AX	9.1
Skin	LOXIMVI	8.9
Skin	MALME3M	8.2
Skin	MDAMB435S	8.4
Skin	MELHO	8.6
Skin	MELJUSO	8.9
Skin	MEWO	8.4
Skin	RPMI7951	8.4
Skin	RVH421	8.6
Skin	SH4	8.6
Skin	SKMEL1	7.9
Skin	SKMEL24	8.4
Skin	SKMEL28	8.1
Skin	SKMEL2	8.5
Skin	SKMEL30	8.2
Skin	SKMEL31	8.3
Skin	SKMEL3	8.7
Skin	SKMEL5	9
Skin	UACC257	9
Skin	UACC62	9.2
Skin	WM115	8.4
Skin	WM1799	8
Skin	WM2664	9.1
Skin	WM793	8.5
Skin	WM88	8.2
Skin	WM983B	7.7
Small intestine	HUTU80	9.2
Soft tissue	A204	9.8
Soft tissue	G401	9.4
Soft tissue	G402	9.3
Soft tissue	GCT	8.4
Soft tissue	HS729	8.9
Soft tissue	HT1080	8.6
Soft tissue	KYM1	7.7
Soft tissue	MESSA	9.7
Soft tissue	RD	9.5
Soft tissue	RH30	10.6
Soft tissue	RH41	8
Soft tissue	RKN	8
Soft tissue	S117	8.8
Soft tissue	SJRH30	8.6
Soft tissue	SKLMS1	9.3
Soft tissue	SKUT1	9.2
Soft tissue	TE125T	8.1
Soft tissue	TE159T	8.9
Soft tissue	TE441T	9.3
Soft tissue	TE617T	9.3
Stomach	2313287	9.3
Stomach	AGS	8.7
Stomach	AZ521	9.4
Stomach	ECC10	9.3
Stomach	ECC12	9
Stomach	FU97	8.9
Stomach	GCIY	8
Stomach	GSS	8.7
Stomach	GSU	8.8
Stomach	HGC27	10.3
Stomach	HS746T	8.8
Stomach	HUG1N	8.5
Stomach	IM95	10.1
Stomach	KATOIII	8.4
Stomach	KE39	8.5
Stomach	LMSU	8.7
Stomach	MKN1	8.6
Stomach	MKN45	9
Stomach	MKN74	8.4
Stomach	MKN7	9.4
Stomach	NCCSTCK140	9.9
Stomach	NCIN87	9.1
Stomach	NUGC2	8.8
Stomach	NUGC3	8.8
Stomach	NUGC4	8.3
Stomach	OCUM1	9.3
Stomach	RERFGC1B	7.9
Stomach	SH10TC	8.6
Stomach	SNU16	10.1
Stomach	SNU1	9.4
Stomach	SNU216	8.9
Stomach	SNU520	9.5
Stomach	SNU5	9.1
Stomach	SNU601	10
Stomach	SNU620	9
Stomach	SNU668	9.5
Stomach	SNU719	9.8
Stomach	TGBC11TKB	9.1
Thyroid	8305C	8.7
Thyroid	8505C	8.7
Thyroid	BCPAP	8.7
Thyroid	BHT101	8
Thyroid	CAL62	9.2
Thyroid	CGTHW1	9
Thyroid	FTC133	9.5
Thyroid	FTC238	8.5
Thyroid	ML1	7.7
Thyroid	SW579	10
Thyroid	TT2609C02	9.2
Thyroid	TT	7.6
Upper aerodigestive tract	BHY	8.4
Upper aerodigestive tract	BICR16	9.1
Upper aerodigestive tract	BICR18	8.4
Upper aerodigestive tract	BICR22	9
Upper aerodigestive tract	BICR31	7.8
Upper aerodigestive tract	BICR56	8.7
Upper aerodigestive tract	BICR6	8.8
Upper aerodigestive tract	CAL27	8.8
Upper aerodigestive tract	CAL33	9.3
Upper aerodigestive tract	DETROIT562	8.5
Upper aerodigestive tract	FADU	8.4
Upper aerodigestive tract	HS840T	9.2
Upper aerodigestive tract	HSC2	8.8
Upper aerodigestive tract	HSC3	8.2
Upper aerodigestive tract	HSC4	8
Upper aerodigestive tract	PECAPJ15	8
Upper aerodigestive tract	PECAPJ34CLONEC12	8.9
Upper aerodigestive tract	PECAPJ41CLONED2	8.7
Upper aerodigestive tract	PECAPJ49	8.7
Upper aerodigestive tract	SCC15	7.5
Upper aerodigestive tract	SCC25	9.4
Upper aerodigestive tract	SCC4	8.5
Upper aerodigestive tract	SCC9	8.2
Upper aerodigestive tract	SNU1076	7.3
Upper aerodigestive tract	SNU1214	8.8
Upper aerodigestive tract	SNU46	9.3
Upper aerodigestive tract	SNU899	8.2
Upper aerodigestive tract	YD10B	8.4
Upper aerodigestive tract	YD38	8.6
Upper aerodigestive tract	YD8	8.8
Urinary tract	5637	9
Urinary tract	639V	10.3
Urinary tract	647V	8.6
Urinary tract	BC3C	9.3
Urinary tract	BFTC905	10.1
Urinary tract	CAL29	7.7
Urinary tract	HS172T	7.8
Urinary tract	HT1197	8.4
Urinary tract	HT1376	8.3
Urinary tract	J82	8.7
Urinary tract	JMSU1	9.7
Urinary tract	KMBC2	7.6
Urinary tract	KU1919	8.6
Urinary tract	RT11284	8.4
Urinary tract	RT112	9.2
Urinary tract	RT4	8.3
Urinary tract	SCABER	8.7
Urinary tract	SW1710	8.8
Urinary tract	SW780	8.1
Urinary tract	T24	8.8
Urinary tract	TCCSUP	8.6
Urinary tract	UMUC1	9.8
Urinary tract	UMUC3	8.2
Urinary tract	VMCUB1	7.7

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	20.2
Adrenal gland	14.1
Appendix	26.9
Bone marrow	13.9
Breast	7.8
Cerebral cortex	20.6
Cervix, uterine	27
Colon	18.9
Duodenum	17.3
Endometrium	25.7
Epididymis	8.9
Esophagus	30.6
Fallopian tube	33.1
Gallbladder	22.5
Heart muscle	15.3
Kidney	10.3
Liver	5.4
Lung	16
Lymph node	23
Ovary	21.2
Pancreas	4
Parathyroid gland	18.1
Placenta	28.9
Prostate	19.4
Rectum	16.1
Salivary gland	6.7
Seminal vesicle	23.8
Skeletal muscle	37.1
Skin	19.6
Small intestine	19.9
Smooth muscle	30.4
Spleen	15.3
Stomach	12.5
Testis	36.6
Thyroid gland	15.6
Tonsil	14.8
Urinary bladder	26.2

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
26224097	Underexpression	Endometriosis	Downregulation of CARM1 protein expression was also detected in the ovary, fully-grown oocytes and eutopic endometrium following 15 months of endometriosis.
26848779	Overexpression	Breast Carcinoma; Prostate Carcinoma; Hepatocellular Carcinoma	CARM1 overexpression has been implicated in breast, prostate, and liver cancers and therefore is an attractive target for cancer therapy.
26601288	Overexpression	Breast Carcinoma	Not only are the expression levels of CARM1 and MED12 positively correlated, but their high expression also predicts better prognosis in human breast cancers after chemotherapy.
26505218	Overexpression	Breast Carcinoma	Coactivator-associated arginine methyltransferase 1 (CARM1) is known to promote estrogen receptor (ER)α-mediated transcription in breast cancer cells.
25906418	Loss of expression	Pulmonary Emphysema	Complete loss of CARM1 leads to disrupted differentiation and maturation of alveolar epithelial type II (ATII) cells. We thus hypothesized that CARM1 regulates the development and progression of emphysema.
24434208	Overexpression	Breast Carcinoma	Coactivator-associated arginine methyltransferase 1 (CARM1), a coactivator for various cancer-relevant transcription factors, is overexpressed in breast cancer.
24332853	Overexpression	Acute Myeloid Leukemia	We found that PRMT4, a type I arginine methyltransferase whose function in normal and malignant hematopoiesis is unknown, is overexpressed in acute myelogenous leukemia patient samples.
24211191	Overexpression	Non-small Cell Lung Carcinoma	We report that CARM1 and PRMT1 are significantly overexpressed in 60 patients with Non-Small Cell Lung Carcinomas (NSCLC). Accordingly, CARM1 and PRMT1 are overexpressed in 2 NSCLC cell lines, A549 and H1299.
23915145	Overexpression	Breast Carcinoma	Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes. Staining for CARM1 was significantly stronger in adenocarcinoma compared with adjacent benign epithelium. CARM1 expression was increased in invasive breast cancer.
23912631	Overexpression	Hepatocellular Carcinoma	Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis. In the present study, we found that the expression of coactivator-associated arginine methyltransferase 1 (CARM1), a histone methyltransferase that functions as a cofactor for nuclear hormone receptors and several transcription factors, was elevated in adenomas and aberrant in carcinomas during hepatocellular carcinogenesis. In addition to RNA expression, immunohistochemical staining of liver sections revealed that CARM1 was highly expressed in the nucleus of tumor marker glutathione S-transferase placental form (GST-P)-positive foci.
23887673	Overexpression	Breast Carcinoma	In the whole series, increased CARM1 expression is correlated with features associated with aggressive behaviour such as young age, premenopausal status, large tumour size and high tumour grade.
23663560	Overexpression	Breast Carcinoma	We found that levels of cytoplasmic CARM1 are distinct among tumor sub-types and increased levels are associated with ER-negative (ER-) status.
23265702	Underexpression	Melanoma	Our findings demonstrate that expression of PRMT4/CARM1 and PRMT6 is deregulated in melanoma, whereas expression of the remaining PRMTs stays unchanged.
25436604	Overexpression	Hodgkin Lymphoma	We first show that the protein arginine methyltransferases, CARM1, PRMT1 and PRMT5 are strongly expressed in Hodgkin Reed-Sternberg (HRS) cells, and up-regulated in Hodgkin's lymphoma (HL) cell lines. EBV infection of GC B cells was followed by the up-regulation of CARM1, PRMT1 and PRMT5, and by the down-regulation of the arginine deiminase, PADI4.
21478268	Overexpression	Colorectal Carcinoma	In colorectal cancer cells with constitutively high Wnt/β-catenin activity, depletion of CARM1 inhibits expression of endogenous Wnt/β-catenin target genes and suppresses clonal survival and anchorage-independent growth.
21282336	Overexpression	Breast Neoplasm	In human breast tumors, CARM1 expression positively correlated with ERα levels in ER-positive tumors but was inversely correlated with tumor grade. Our findings suggest that coexpression of CARM1 and ERα may provide a better biomarker of well-differentiated breast cancer.
20530543	Overexpression	Breast Carcinoma; Prostate Adenocarcinoma	In adults, CARM1 is overexpressed in human grade-III breast tumors and prostate adenocarcinomas, and knockdown of CARM1 inhibits proliferation of breast and prostate cancer cell lines.
20462455	Overexpression	Colorectal Carcinoma; Prostate Carcinoma	Correspondingly, overexpression of CARM1 has been associated with the development of prostate cancer (PCa) and its progression to androgen-independent PCa. CARM1 expression was also evaluated in prostate and colorectal surgical specimens and the clinical records of all cases were reviewed. The tissue microarray showed that CARM1 was particularly overexpressed in the colorectal cancers while CARM1 expression was not prevalent in the prostate and breast cancers.
18172323	Overexpression	Breast Carcinoma	CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. Here, we show that CARM1 is essential for estrogen-induced cell cycle progression in the MCF-7 breast cancer cell line.
16938873	Overexpression	Breast Carcinoma	Finally, we show that grade-3 breast tumors present coelevated mRNA levels of ACTR and CARM1, along with their transcriptional target CCNE1.
16705743	Overexpression	Prostate Carcinoma	CARM1 expression was increased in the nucleus of castration-resistant, but not androgen-stimulated prostate cancer.
15221992	Overexpression	Prostate Adenocarcinoma	The staining intensity for CARM1 was significantly lower in benign prostate tissue specimens compared with PIN and prostatic adenocarcinoma specimens (P < 0.001). In the 12 patients with androgen-independent prostatic adenocarcinoma, the expression of CARM1 was significantly increased when compared with patients without previous hormonal treatment.
28345460	Overexpression	Colorectal Carcinoma	Expression analysis verified that microRNA-195-5p was markedly downregulated in human colorectal cancer tissues, which was negatively correlated with the elevated levels of coactivator-associated arginine methyltransferase 1 protein.
28255246	Overexpression	Colorectal Carcinoma	miR-195 was downregulated, and CARM1 was upregulated in HCT-116 and HT-29 cells.

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.492	5.26e-26	29.2	51	19.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.533	5.35e-80	21.3	59.5	19.2	Neutral
CESC	Cervical and endocervical cancers	292	0.627	2.94e-33	26.7	58.9	14.4	Neutral
COAD	Colon adenocarcinoma	449	0.331	6.47e-13	10	74.2	15.8	Neutral
ESCA	Esophageal carcinoma	183	0.561	1.57e-16	39.9	44.3	15.8	Loss
GBM	Glioblastoma multiforme	147	0.471	1.67e-09	8.2	55.8	36.1	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.495	3.76e-33	21.2	66.7	12.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.167	0.000117	2.5	88.4	9.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.287	7e-07	6.6	91.3	2.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.358	2.13e-06	1.8	95.2	3	Neutral
LGG	Brain Lower Grade Glioma	513	0.204	3.11e-06	3.3	73.7	23	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.592	7.74e-36	22.5	64.3	13.2	Neutral
LUAD	Lung adenocarcinoma	512	0.468	3.15e-29	52.1	43.8	4.1	Loss
LUSC	Lung squamous cell carcinoma	498	0.631	1.11e-56	38.4	41.6	20.1	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.789	7.11e-65	32.7	25.3	42	Gain
PAAD	Pancreatic adenocarcinoma	177	0.385	1.2e-07	15.3	76.3	8.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.336	1.24e-05	0.6	86.4	13	Neutral
PRAD	Prostate adenocarcinoma	491	0.364	8.61e-17	5.5	92.7	1.8	Neutral
READ	Rectum adenocarcinoma	164	0.302	8.44e-05	16.5	63.4	20.1	Neutral
SARC	Sarcoma	255	0.613	9.55e-28	10.2	47.5	42.4	Gain
SKCM	Skin Cutaneous Melanoma	367	0.347	8.54e-12	22.9	60.5	16.6	Neutral
STAD	Stomach adenocarcinoma	413	0.442	3.18e-21	30.8	58.8	10.4	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.406	2.49e-07	31.3	43.3	25.3	Neutral
THCA	Thyroid carcinoma	497	0.29	4.3e-11	1.4	97.2	1.4	Neutral
THYM	Thymoma	119	0.089	0.336	3.4	94.1	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.567	4.64e-47	10.1	73.4	16.6	Neutral

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.24	5.79e-07	17	408	-0.003	0.0309	NS/NA
BRCA	Breast invasive carcinoma	-0.225	2.34e-11	83	785	0	0.042	NS/NA
CESC	Cervical and endocervical cancers	-0.215	0.000148	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.173	0.00205	19	297	0	0.276	NS/NA
ESCA	Esophageal carcinoma	-0.099	0.171	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.141	0.263	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.192	7.41e-06	20	522	0.005	6.11e-06	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.096	0.0754	24	319	-0.003	0.186	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.072	0.218	23	275	0.002	0.643	NS/NA
LAML	Acute Myeloid Leukemia	-0.216	0.00482	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.1	0.0209	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.216	9.59e-06	41	373	0	0.0736	NS/NA
LUAD	Lung adenocarcinoma	-0.199	1.19e-05	21	456	0.001	0.653	NS/NA
LUSC	Lung squamous cell carcinoma	-0.218	1.94e-05	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.783	0.0172	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.211	0.00416	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.076	0.299	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.18	3.15e-05	35	498	0.002	0.00758	NS/NA
READ	Rectum adenocarcinoma	-0.201	0.0435	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.239	9.44e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.178	0.000105	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.061	0.24	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.363	3.78e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.132	0.00177	50	509	-0.002	0.0406	NS/NA
THYM	Thymoma	-0.11	0.228	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.118	0.0111	34	431	-0.001	0.269	NS/NA

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	3	High
Breast	2	Medium
Bronchus	2	Medium
Caudate	3	High
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	3	High
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	1	Low
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	1	Low
Kidney	3	High
Liver	2	Medium
Lung	2	Medium
Lymph node	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	1	Low
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	2	Medium
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	2	Medium
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.939	NS	24476821
BRCA	Breast invasive carcinoma	521	2.05e-11	Significant	23000897
COAD	Colon adenocarcinoma	149	0.204	NS	22810696
GBM	Glioblastoma multiforme	157	0.00706	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	6.01e-05	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0933	NS	26536169
LGG	Brain Lower Grade Glioma	513	3.05e-21	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00207	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	3e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0375	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0291	Significant	26544944
READ	Rectum adenocarcinoma	67	0.37	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0523	NS	26091043
STAD	Stomach adenocarcinoma	277	0.00496	Significant	25079317
THCA	Thyroid carcinoma	391	1.35e-06	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000801	Significant	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.581	0.027	Shorter
BRCA	Breast invasive carcinoma	1079	0.99	0.963	NS
CESC	Cervical and endocervical cancers	291	1.016	0.959	NS
COAD	Colon adenocarcinoma	439	0.951	0.855	NS
ESCA	Esophageal carcinoma	184	0.745	0.379	NS
GBM	Glioblastoma multiforme	158	1.346	0.24	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.89	0.558	NS
KIRC	Kidney renal clear cell carcinoma	531	2.242	0.000149	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.867	0.151	NS
LAML	Acute Myeloid Leukemia	149	1.881	0.0219	Shorter
LGG	Brain Lower Grade Glioma	511	2.107	0.00236	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.001	0.997	NS
LUAD	Lung adenocarcinoma	502	1.696	0.0139	Shorter
LUSC	Lung squamous cell carcinoma	494	0.755	0.147	NS
OV	Ovarian serous cystadenocarcinoma	303	0.649	0.0408	Longer
PAAD	Pancreatic adenocarcinoma	177	0.882	0.679	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.455	0.51	NS
PRAD	Prostate adenocarcinoma	497	1.461	0.762	NS
READ	Rectum adenocarcinoma	159	1.223	0.748	NS
SARC	Sarcoma	259	1.36	0.282	NS
SKCM	Skin Cutaneous Melanoma	459	1.744	0.00216	Shorter
STAD	Stomach adenocarcinoma	388	0.712	0.136	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.153	NS
THCA	Thyroid carcinoma	500	0.787	0.705	NS
THYM	Thymoma	119	0.8	0.809	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.687	0.194	NS

> Stage

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Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.025	0.611	NS
BRCA	Breast invasive carcinoma	1071	0.03	0.331	NS
CESC	Cervical and endocervical cancers	167	0.052	0.505	NS
COAD	Colon adenocarcinoma	445	0.014	0.774	NS
ESCA	Esophageal carcinoma	162	-0.223	0.00432	Lower
HNSC	Head and Neck squamous cell carcinoma	448	-0.014	0.761	NS
KIRC	Kidney renal clear cell carcinoma	531	0.209	1.18e-06	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.24	9.36e-05	Higher
LIHC	Liver hepatocellular carcinoma	347	0.039	0.464	NS
LUAD	Lung adenocarcinoma	507	0.098	0.0275	Higher
LUSC	Lung squamous cell carcinoma	497	0.036	0.429	NS
OV	Ovarian serous cystadenocarcinoma	302	0.024	0.677	NS
PAAD	Pancreatic adenocarcinoma	176	-0.054	0.473	NS
READ	Rectum adenocarcinoma	156	-0.021	0.797	NS
SKCM	Skin Cutaneous Melanoma	410	-0.052	0.289	NS
STAD	Stomach adenocarcinoma	392	-0.104	0.0389	Lower
TGCT	Testicular Germ Cell Tumors	81	0.056	0.618	NS
THCA	Thyroid carcinoma	499	0.082	0.0672	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.03	0.498	NS

> Grade

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Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.023	0.704	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.077	0.0844	NS
KIRC	Kidney renal clear cell carcinoma	525	0.277	1.02e-10	Higher
LGG	Brain Lower Grade Glioma	514	0.185	2.46e-05	Higher
LIHC	Liver hepatocellular carcinoma	366	0.093	0.0766	NS
OV	Ovarian serous cystadenocarcinoma	296	0.031	0.591	NS
PAAD	Pancreatic adenocarcinoma	176	0.076	0.316	NS
STAD	Stomach adenocarcinoma	406	-0.096	0.0533	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.019	0.66	NS

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for CARM1.

Summary
Symbol	CARM1
Name	coactivator associated arginine methyltransferase 1
Aliases	PRMT4; Histone-arginine methyltransferase CARM1
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26601288	Breast Carcinoma	partner	MED12	Positive correlation	Not only are the expression levels of CARM1 and MED12 positively correlated, but their high expression also predicts better prognosis in human breast cancers after chemotherapy.
26505218	Breast Carcinoma	partner	DZIP3	Binding	However, ERα reporter gene assays demonstrated that DZIP3 enhanced ERα-mediated transcription and cooperated synergistically with CARM1. Interaction with CARM1 was observed with the E3 ligase RING domain of DZIP3.
24211191	Non-small Cell Lung Carcinoma	downstream	PRMT1	Negative regulation	The fact that CARM1 targeting suppresses PRMT1 in addition to CARM1 reinforces the functional importance of CARM1/PRMT1 interaction.
23915145	Breast Carcinoma	partner	HER2	Positive correlation	Our study demonstrated CARM1 overexpression was associated with an increase in the protein expression of HER2. CARM1 overexpression was associated with poorly characterized clinicopathologic parameters and HER2 overexpression.
23887673	Breast Carcinoma	partner	HER2; Basal Cytokeratins; EGFR; p53; Ki67; TK1; CD71; Cyclin E	Positive correlation	There is a positive correlation between CARM1 expression and biomarkers associated with non-luminal phenotype and poor prognosis such as HER2, basal cytokeratins, EGFR, p53 and the proliferation markers Ki67, TK1, CD71 and Cyclin E. Negative associations with the luminal-associated markers including steroid receptors and luminal cytokeratins are found.
21478268	Colorectal Carcinoma	downstream	Wnt/β-catenin	Positive regulation	In colorectal cancer cells with constitutively high Wnt/β-catenin activity, depletion of CARM1 inhibits expression of endogenous Wnt/β-catenin target genes and suppresses clonal survival and anchorage-independent growth. Therefore, CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation, and may thereby represent a novel target for therapeutic intervention in cancers involving aberrantly activated Wnt/β-catenin signaling.
21282336	Breast Neoplasm	partner	ERα	Positive correlation	In human breast tumors, CARM1 expression positively correlated with ERα levels in ER-positive tumors but was inversely correlated with tumor grade. Our findings suggest that coexpression of CARM1 and ERα may provide a better biomarker of well-differentiated breast cancer.
18172323	Breast Carcinoma	downstream	E2F1	Positive regulation	CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.
16705743	Prostate Carcinoma	downstream	AR	Positive regulation	Overexpression of CARM1 stimulated and CARM1 knockdown inhibited AR reporter activity.
15221992	Prostate Adenocarcinoma	downstream	AR	Positive regulation	Coactivator-associated arginine methyltransferase 1 (CARM1) is a transcriptional coactivator of the androgen receptor (AR).
28345460	Colorectal Carcinoma	upstream	miR-195-5p	Negative regulation	Using bioinformatics-based prediction and luciferase reporter system, we found that coactivator-associated arginine methyltransferase 1 is post-transcriptionally targeted by microRNA-195-5p in colorectal cancer. Expression analysis verified that microRNA-195-5p was markedly downregulated in human colorectal cancer tissues, which was negatively correlated with the elevated levels of coactivator-associated arginine methyltransferase 1 protein.