CR2Cancer

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00385 Chromo (CHRromatin Organisation MOdifier) domain
PF01393 Chromo shadow domain

Function

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K9me3	#	21047797

> Gene Ontology [ TOP ]
Biological Process	GO:0006338 chromatin remodeling GO:0048511 rhythmic process
Molecular Function	GO:1990226 histone methyltransferase binding
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000779 condensed chromosome, centromeric region GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0000792 heterochromatin GO:0000793 condensed chromosome GO:0005635 nuclear envelope GO:0005637 nuclear inner membrane GO:0005719 nuclear euchromatin GO:0005720 nuclear heterochromatin GO:0005721 pericentric heterochromatin GO:0005819 spindle GO:0031618 nuclear pericentric heterochromatin GO:0031965 nuclear membrane GO:0044454 nuclear chromosome part GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-73777: RNA Polymerase I Chain Elongation R-HSA-73864: RNA Polymerase I Transcription R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-73777: RNA Polymerase I Chain Elongation
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1450169	c.36delA	p.K14fs*23	Deletion - Frameshift	Large_intestine
COSM5438206	c.367C>T	p.P123S	Substitution - Missense	Oesophagus
COSM1088804	c.93C>T	p.V31V	Substitution - coding silent	Prostate
COSM4840432	c.185A>C	p.E62A	Substitution - Missense	Cervix
COSM1166109	c.25-2A>T	p.?	Unknown	Large_intestine
COSM4587339	c.253G>T	p.E85*	Substitution - Nonsense	Bone
COSM4994683	c.167_167+1ins68	p.S79fs*12	Unknown	Large_intestine
COSM3637686	c.49G>A	p.G17R	Substitution - Missense	Skin
COSM5769585	c.331-3C>G	p.?	Unknown	Breast
COSM452905	c.420G>A	p.M140I	Substitution - Missense	Breast
COSM1450168	c.26delA	p.M11fs*26	Deletion - Frameshift	Large_intestine
COSM1088804	c.93C>T	p.V31V	Substitution - coding silent	Prostate
COSM3026867	c.21A>G	p.T7T	Substitution - coding silent	Large_intestine
COSM1088806	c.128G>A	p.G43E	Substitution - Missense	Endometrium
COSM4168152	c.85G>T	p.E29*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5415018	c.179C>T	p.T60I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4669564	c.487A>T	p.I163F	Substitution - Missense	Large_intestine
COSM1166109	c.25-2A>T	p.?	Unknown	Pancreas
COSM397862	c.415C>T	p.L139F	Substitution - Missense	Lung
COSM4169193	c.206G>A	p.C69Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4598959	c.411G>A	p.M137I	Substitution - Missense	Upper_aerodigestive_tract
COSM1088802	c.36A>G	p.G12G	Substitution - coding silent	Endometrium
COSM1450169	c.36delA	p.K14fs*23	Deletion - Frameshift	Large_intestine
COSM1199733	c.195A>C	p.E65D	Substitution - Missense	Large_intestine
COSM1088804	c.93C>T	p.V31V	Substitution - coding silent	Prostate
COSM5953174	c.36_37insA	p.Q15fs*6	Insertion - Frameshift	Oesophagus
COSM1088804	c.93C>T	p.V31V	Substitution - coding silent	Prostate
COSM184080	c.458C>T	p.A153V	Substitution - Missense	Large_intestine
COSM1088804	c.93C>T	p.V31V	Substitution - coding silent	Endometrium
COSM452904	c.282A>G	p.L94L	Substitution - coding silent	Breast
COSM1088803	c.73G>A	p.A25T	Substitution - Missense	Endometrium
COSM74021	c.2T>G	p.M1R	Substitution - Missense	Ovary
COSM1088808	c.546T>A	p.A182A	Substitution - coding silent	Endometrium
COSM5367731	c.35_36insA	p.Q15fs*6	Insertion - Frameshift	Large_intestine
COSM3663120	c.421A>G	p.K141E	Substitution - Missense	Liver
COSM3026867	c.21A>G	p.T7T	Substitution - coding silent	Large_intestine
COSM3663120	c.421A>G	p.K141E	Substitution - Missense	Liver
COSM4915640	c.232A>G	p.N78D	Substitution - Missense	Liver
COSM1450168	c.26delA	p.M11fs*26	Deletion - Frameshift	Large_intestine
COSM1088807	c.218T>A	p.I73N	Substitution - Missense	Endometrium
COSM1166109	c.25-2A>T	p.?	Unknown	Kidney
COSM1450168	c.26delA	p.M11fs*26	Deletion - Frameshift	Large_intestine
COSM1088804	c.93C>T	p.V31V	Substitution - coding silent	Prostate
COSM1088801	c.28A>C	p.K10Q	Substitution - Missense	Endometrium
COSM5803848	c.203A>G	p.D68G	Substitution - Missense	Liver
COSM1088805	c.94G>A	p.V32M	Substitution - Missense	Endometrium
COSM5407279	c.414T>C	p.F138F	Substitution - coding silent	Skin
COSM1450168	c.26delA	p.M11fs*26	Deletion - Frameshift	Large_intestine

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
25499959	Mutation	Gastric Cardia Adenocarcinoma	Moreover, we firstly discovered 3 fusion genes in GCA, including BMX-ARHGAP, LRP5- LITAF and CBX3-C15orf57.

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q13185	5	K	N6-acetyllysine	-	No	None detected
Q13185	10	K	N6-acetyllysine	-	Yes	p.K10Q (cancer: UCEC)
Q13185	44	K	N6-acetyllysine	-	No	None detected
Q13185	50	K	N6-acetyllysine	-	No	None detected
Q13185	93	S	Phosphoserine	-	No	None detected
Q13185	95	S	Phosphoserine	-	No	None detected
Q13185	97	S	Phosphoserine	-	No	None detected
Q13185	99	S	Phosphoserine	-	No	None detected
Q13185	176	S	Phosphoserine	-	No	None detected

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.688	7.746	0.938	6.71e-15	Over
BRCA	Breast invasive carcinoma	112	1100	6.969	7.907	0.956	8.84e-70	Over
CESC	Cervical and endocervical cancers	3	306	7.085	7.801	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.603	7.826	1.057	7.42e-16	Over
ESCA	Esophageal carcinoma	11	185	5.878	7.197	1.348	1.74e-11	Over
GBM	Glioblastoma multiforme	5	166	6.29	7.781	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.336	7.263	0.896	9.39e-26	Over
KIRC	Kidney renal clear cell carcinoma	72	534	6.674	7.076	0.45	3.13e-19	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.37	7.315	0.916	1.18e-25	Over
LAML	Acute Myeloid Leukemia	0	173	NA	7.247	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.245	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.874	6.356	0.526	6.6e-13	NS
LUAD	Lung adenocarcinoma	59	517	6.565	7.635	0.992	1.7e-31	Over
LUSC	Lung squamous cell carcinoma	51	501	6.424	7.602	1.145	3.53e-40	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.472	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.063	7.079	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.359	6.512	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.386	6.842	0.439	1.3e-09	NS
READ	Rectum adenocarcinoma	10	167	6.999	7.853	0.62	0.048	Over
SARC	Sarcoma	2	263	6.789	7.193	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	9.137	8.027	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.104	7.16	1.006	8.18e-19	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	8.774	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.571	7.087	0.455	1.27e-21	NS
THYM	Thymoma	2	120	7.576	7.845	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.097	7.435	0.468	0.000294	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	12.6
Autonomic ganglia	CHP212	12.5
Autonomic ganglia	IMR32	12.2
Autonomic ganglia	KELLY	13.1
Autonomic ganglia	KPNRTBM1	12.7
Autonomic ganglia	KPNSI9S	12.5
Autonomic ganglia	KPNYN	12.8
Autonomic ganglia	MHHNB11	11.9
Autonomic ganglia	NB1	13.1
Autonomic ganglia	NH6	12.6
Autonomic ganglia	SHSY5Y	12.8
Autonomic ganglia	SIMA	12.7
Autonomic ganglia	SKNAS	12.3
Autonomic ganglia	SKNBE2	12.8
Autonomic ganglia	SKNDZ	12.7
Autonomic ganglia	SKNFI	12.4
Autonomic ganglia	SKNSH	12.5
Biliary tract	HUCCT1	12.7
Biliary tract	HUH28	11.8
Biliary tract	SNU1079	12.7
Biliary tract	SNU1196	12
Biliary tract	SNU245	12.3
Biliary tract	SNU308	11.8
Biliary tract	SNU478	12.3
Bone	143B	12.7
Bone	A673	11.5
Bone	CADOES1	12.4
Bone	CAL78	12.9
Bone	G292CLONEA141B1	12.1
Bone	HOS	12.7
Bone	HS706T	11.6
Bone	HS737T	11.2
Bone	HS819T	11
Bone	HS821T	11.3
Bone	HS822T	11
Bone	HS863T	11.6
Bone	HS870T	11.9
Bone	HS888T	11.7
Bone	MG63	12.2
Bone	MHHES1	12.1
Bone	OUMS27	12.3
Bone	RDES	11.6
Bone	SJSA1	11.8
Bone	SKES1	12.5
Bone	SKNMC	12.1
Bone	SW1353	12.2
Bone	T173	11.1
Bone	TC71	11.9
Bone	U2OS	12.2
Breast	AU565	12.2
Breast	BT20	12.1
Breast	BT474	12.7
Breast	BT483	12.3
Breast	BT549	11.9
Breast	CAL120	11.9
Breast	CAL148	12.7
Breast	CAL51	12.2
Breast	CAL851	11.6
Breast	CAMA1	12.1
Breast	DU4475	12.6
Breast	EFM192A	11
Breast	EFM19	12.3
Breast	EVSAT	12
Breast	HCC1143	11.6
Breast	HCC1187	12.7
Breast	HCC1395	11.9
Breast	HCC1419	11.9
Breast	HCC1428	12.5
Breast	HCC1500	12.3
Breast	HCC1569	12.1
Breast	HCC1599	12.7
Breast	HCC1806	12.1
Breast	HCC1937	12.3
Breast	HCC1954	12.4
Breast	HCC202	12.7
Breast	HCC2157	11.8
Breast	HCC2218	11.9
Breast	HCC38	11.4
Breast	HCC70	12.6
Breast	HDQP1	12.4
Breast	HMC18	12.3
Breast	HS274T	11.2
Breast	HS281T	11.4
Breast	HS343T	11.6
Breast	HS578T	11.5
Breast	HS606T	11.7
Breast	HS739T	11.5
Breast	HS742T	11.5
Breast	JIMT1	11.8
Breast	KPL1	12.7
Breast	MCF7	12.4
Breast	MDAMB134VI	12.7
Breast	MDAMB157	12.8
Breast	MDAMB175VII	12
Breast	MDAMB231	11.8
Breast	MDAMB361	11.7
Breast	MDAMB415	11.4
Breast	MDAMB436	11.8
Breast	MDAMB453	12
Breast	MDAMB468	12.5
Breast	SKBR3	12.2
Breast	T47D	12.3
Breast	UACC812	11.7
Breast	UACC893	12.5
Breast	YMB1	12.5
Breast	ZR751	13.2
Breast	ZR7530	12.1
Central nervous system	1321N1	11.9
Central nervous system	42MGBA	12.2
Central nervous system	8MGBA	12.7
Central nervous system	A172	12.3
Central nervous system	AM38	12.1
Central nervous system	BECKER	12.3
Central nervous system	CAS1	12.1
Central nervous system	CCFSTTG1	12.2
Central nervous system	D283MED	12.1
Central nervous system	D341MED	12.2
Central nervous system	DAOY	13.3
Central nervous system	DBTRG05MG	11.8
Central nervous system	DKMG	12.2
Central nervous system	GAMG	12.6
Central nervous system	GB1	12.8
Central nervous system	GI1	12.6
Central nervous system	GMS10	12.1
Central nervous system	GOS3	12.2
Central nervous system	H4	12.5
Central nervous system	HS683	12.4
Central nervous system	KALS1	12
Central nervous system	KG1C	12.3
Central nervous system	KNS42	12.6
Central nervous system	KNS60	12.6
Central nervous system	KNS81	12.6
Central nervous system	KS1	12.3
Central nervous system	LN18	12.4
Central nervous system	LN229	12.6
Central nervous system	M059K	11.9
Central nervous system	MOGGCCM	12.5
Central nervous system	MOGGUVW	12.6
Central nervous system	NMCG1	12.4
Central nervous system	ONS76	12.1
Central nervous system	SF126	12.5
Central nervous system	SF295	12.2
Central nervous system	SNB19	12.5
Central nervous system	SNU1105	12
Central nervous system	SNU201	11.7
Central nervous system	SNU466	12.1
Central nervous system	SNU489	11.2
Central nervous system	SNU626	12.4
Central nervous system	SNU738	12.6
Central nervous system	SW1088	12.4
Central nervous system	SW1783	12
Central nervous system	T98G	12.2
Central nervous system	TM31	12.4
Central nervous system	U118MG	12.2
Central nervous system	U138MG	12
Central nervous system	U251MG	12.1
Central nervous system	U87MG	11.5
Central nervous system	YH13	11.8
Central nervous system	YKG1	12.8
Endometrium	AN3CA	12.4
Endometrium	COLO684	12.4
Endometrium	EFE184	11.9
Endometrium	EN	11.3
Endometrium	ESS1	12.2
Endometrium	HEC108	11.6
Endometrium	HEC151	12.4
Endometrium	HEC1A	12.8
Endometrium	HEC1B	12.1
Endometrium	HEC251	12
Endometrium	HEC265	12.1
Endometrium	HEC50B	12.1
Endometrium	HEC59	12.4
Endometrium	HEC6	12.5
Endometrium	ISHIKAWAHERAKLIO02ER	12.3
Endometrium	JHUEM1	11.4
Endometrium	JHUEM2	12.5
Endometrium	JHUEM3	11.5
Endometrium	KLE	12
Endometrium	MFE280	12.2
Endometrium	MFE296	11.7
Endometrium	MFE319	11.3
Endometrium	RL952	11.5
Endometrium	SNGM	11.9
Endometrium	SNU1077	11.7
Endometrium	SNU685	12.4
Endometrium	TEN	12.4
Haematopoietic and lymphoid	697	12.5
Haematopoietic and lymphoid	A3KAW	12.4
Haematopoietic and lymphoid	A4FUK	12.7
Haematopoietic and lymphoid	ALLSIL	12.8
Haematopoietic and lymphoid	AML193	12.4
Haematopoietic and lymphoid	AMO1	12.4
Haematopoietic and lymphoid	BCP1	12.5
Haematopoietic and lymphoid	BDCM	12.3
Haematopoietic and lymphoid	BL41	12.9
Haematopoietic and lymphoid	BL70	13
Haematopoietic and lymphoid	BV173	12.2
Haematopoietic and lymphoid	CA46	12.1
Haematopoietic and lymphoid	CI1	12.6
Haematopoietic and lymphoid	CMK115	12.4
Haematopoietic and lymphoid	CMK86	12.3
Haematopoietic and lymphoid	CMK	11.9
Haematopoietic and lymphoid	CMLT1	12.4
Haematopoietic and lymphoid	COLO775	12
Haematopoietic and lymphoid	DAUDI	12.3
Haematopoietic and lymphoid	DB	12.3
Haematopoietic and lymphoid	DEL	12.3
Haematopoietic and lymphoid	DND41	12.3
Haematopoietic and lymphoid	DOHH2	12.9
Haematopoietic and lymphoid	EB1	11.9
Haematopoietic and lymphoid	EB2	12
Haematopoietic and lymphoid	EHEB	12.1
Haematopoietic and lymphoid	EJM	11.7
Haematopoietic and lymphoid	EM2	12.2
Haematopoietic and lymphoid	EOL1	12.4
Haematopoietic and lymphoid	F36P	11.6
Haematopoietic and lymphoid	GA10	12.7
Haematopoietic and lymphoid	GDM1	12
Haematopoietic and lymphoid	GRANTA519	12.2
Haematopoietic and lymphoid	HDLM2	11.4
Haematopoietic and lymphoid	HDMYZ	11.9
Haematopoietic and lymphoid	HEL9217	12.1
Haematopoietic and lymphoid	HEL	12
Haematopoietic and lymphoid	HH	12.5
Haematopoietic and lymphoid	HL60	12.1
Haematopoietic and lymphoid	HPBALL	12.3
Haematopoietic and lymphoid	HS604T	11.1
Haematopoietic and lymphoid	HS611T	12.1
Haematopoietic and lymphoid	HS616T	11.3
Haematopoietic and lymphoid	HS751T	11.7
Haematopoietic and lymphoid	HT	12.3
Haematopoietic and lymphoid	HTK	12.4
Haematopoietic and lymphoid	HUNS1	12.5
Haematopoietic and lymphoid	HUT102	12
Haematopoietic and lymphoid	HUT78	12.6
Haematopoietic and lymphoid	JEKO1	12.4
Haematopoietic and lymphoid	JK1	11.5
Haematopoietic and lymphoid	JM1	12.6
Haematopoietic and lymphoid	JURKAT	12.6
Haematopoietic and lymphoid	JURLMK1	12.5
Haematopoietic and lymphoid	JVM2	11.9
Haematopoietic and lymphoid	JVM3	12
Haematopoietic and lymphoid	K562	11.8
Haematopoietic and lymphoid	KARPAS299	12.1
Haematopoietic and lymphoid	KARPAS422	11.9
Haematopoietic and lymphoid	KARPAS620	12.9
Haematopoietic and lymphoid	KASUMI1	12.6
Haematopoietic and lymphoid	KASUMI2	11.9
Haematopoietic and lymphoid	KASUMI6	12.3
Haematopoietic and lymphoid	KCL22	12.2
Haematopoietic and lymphoid	KE37	12.8
Haematopoietic and lymphoid	KE97	12.6
Haematopoietic and lymphoid	KG1	12.6
Haematopoietic and lymphoid	KHM1B	12.9
Haematopoietic and lymphoid	KIJK	12.6
Haematopoietic and lymphoid	KMH2	11.9
Haematopoietic and lymphoid	KMM1	12.7
Haematopoietic and lymphoid	KMS11	12.5
Haematopoietic and lymphoid	KMS12BM	12.6
Haematopoietic and lymphoid	KMS18	12.2
Haematopoietic and lymphoid	KMS20	12.4
Haematopoietic and lymphoid	KMS21BM	12.4
Haematopoietic and lymphoid	KMS26	12.2
Haematopoietic and lymphoid	KMS27	12
Haematopoietic and lymphoid	KMS28BM	12.5
Haematopoietic and lymphoid	KMS34	12.8
Haematopoietic and lymphoid	KO52	12.4
Haematopoietic and lymphoid	KOPN8	12.4
Haematopoietic and lymphoid	KU812	12.2
Haematopoietic and lymphoid	KYO1	12
Haematopoietic and lymphoid	L1236	12.6
Haematopoietic and lymphoid	L363	12.5
Haematopoietic and lymphoid	L428	12.2
Haematopoietic and lymphoid	L540	12.4
Haematopoietic and lymphoid	LAMA84	12.2
Haematopoietic and lymphoid	LOUCY	12.8
Haematopoietic and lymphoid	LP1	11.5
Haematopoietic and lymphoid	M07E	12.5
Haematopoietic and lymphoid	MC116	12.8
Haematopoietic and lymphoid	ME1	11.9
Haematopoietic and lymphoid	MEC1	12.7
Haematopoietic and lymphoid	MEC2	12.2
Haematopoietic and lymphoid	MEG01	12.3
Haematopoietic and lymphoid	MHHCALL2	12.7
Haematopoietic and lymphoid	MHHCALL3	12.4
Haematopoietic and lymphoid	MHHCALL4	12.5
Haematopoietic and lymphoid	MINO	13
Haematopoietic and lymphoid	MJ	12.5
Haematopoietic and lymphoid	MM1S	12.2
Haematopoietic and lymphoid	MOLM13	12.4
Haematopoietic and lymphoid	MOLM16	12.5
Haematopoietic and lymphoid	MOLM6	11.9
Haematopoietic and lymphoid	MOLP2	11.9
Haematopoietic and lymphoid	MOLP8	12.2
Haematopoietic and lymphoid	MOLT13	12.7
Haematopoietic and lymphoid	MOLT16	12.5
Haematopoietic and lymphoid	MOLT4	12.4
Haematopoietic and lymphoid	MONOMAC1	12
Haematopoietic and lymphoid	MONOMAC6	12.3
Haematopoietic and lymphoid	MOTN1	12.3
Haematopoietic and lymphoid	MUTZ5	12.4
Haematopoietic and lymphoid	MV411	12.2
Haematopoietic and lymphoid	NALM19	12.6
Haematopoietic and lymphoid	NALM1	12.5
Haematopoietic and lymphoid	NALM6	12.5
Haematopoietic and lymphoid	NAMALWA	12.7
Haematopoietic and lymphoid	NB4	12.9
Haematopoietic and lymphoid	NCIH929	12.6
Haematopoietic and lymphoid	NCO2	12.3
Haematopoietic and lymphoid	NOMO1	12.4
Haematopoietic and lymphoid	NUDHL1	11.5
Haematopoietic and lymphoid	NUDUL1	12.4
Haematopoietic and lymphoid	OCIAML2	12.8
Haematopoietic and lymphoid	OCIAML3	11.7
Haematopoietic and lymphoid	OCIAML5	12.3
Haematopoietic and lymphoid	OCILY10	12.3
Haematopoietic and lymphoid	OCILY19	12.6
Haematopoietic and lymphoid	OCILY3	12.6
Haematopoietic and lymphoid	OCIM1	11.4
Haematopoietic and lymphoid	OPM2	12.4
Haematopoietic and lymphoid	P12ICHIKAWA	12.7
Haematopoietic and lymphoid	P31FUJ	11.5
Haematopoietic and lymphoid	P3HR1	12.6
Haematopoietic and lymphoid	PCM6	11.3
Haematopoietic and lymphoid	PEER	13.1
Haematopoietic and lymphoid	PF382	12.4
Haematopoietic and lymphoid	PFEIFFER	12.6
Haematopoietic and lymphoid	PL21	12.6
Haematopoietic and lymphoid	RAJI	12.5
Haematopoietic and lymphoid	RCHACV	12.6
Haematopoietic and lymphoid	REC1	12
Haematopoietic and lymphoid	REH	12.5
Haematopoietic and lymphoid	RI1	12.5
Haematopoietic and lymphoid	RL	12.9
Haematopoietic and lymphoid	RPMI8226	12.6
Haematopoietic and lymphoid	RPMI8402	12.4
Haematopoietic and lymphoid	RS411	12
Haematopoietic and lymphoid	SEM	12.2
Haematopoietic and lymphoid	SET2	12.3
Haematopoietic and lymphoid	SIGM5	12.5
Haematopoietic and lymphoid	SKM1	12.4
Haematopoietic and lymphoid	SKMM2	12.3
Haematopoietic and lymphoid	SR786	11.9
Haematopoietic and lymphoid	ST486	13
Haematopoietic and lymphoid	SUDHL10	12.3
Haematopoietic and lymphoid	SUDHL1	12.5
Haematopoietic and lymphoid	SUDHL4	12.3
Haematopoietic and lymphoid	SUDHL5	12.8
Haematopoietic and lymphoid	SUDHL6	12.8
Haematopoietic and lymphoid	SUDHL8	12.5
Haematopoietic and lymphoid	SUPB15	12.5
Haematopoietic and lymphoid	SUPHD1	11.1
Haematopoietic and lymphoid	SUPM2	12.8
Haematopoietic and lymphoid	SUPT11	12.5
Haematopoietic and lymphoid	SUPT1	12.7
Haematopoietic and lymphoid	TALL1	12.7
Haematopoietic and lymphoid	TF1	12.2
Haematopoietic and lymphoid	THP1	12.3
Haematopoietic and lymphoid	TO175T	11.5
Haematopoietic and lymphoid	TOLEDO	12.7
Haematopoietic and lymphoid	U266B1	12.8
Haematopoietic and lymphoid	U937	12.4
Haematopoietic and lymphoid	UT7	12.1
Haematopoietic and lymphoid	WSUDLCL2	12.4
Kidney	769P	12.1
Kidney	786O	11.7
Kidney	A498	12.1
Kidney	A704	13
Kidney	ACHN	12.7
Kidney	BFTC909	12
Kidney	CAKI1	11.9
Kidney	CAKI2	12
Kidney	CAL54	12.1
Kidney	KMRC1	12.2
Kidney	KMRC20	11.9
Kidney	KMRC2	12.2
Kidney	KMRC3	11.9
Kidney	OSRC2	11.9
Kidney	RCC10RGB	11.9
Kidney	SNU1272	11.9
Kidney	SNU349	12
Kidney	TUHR10TKB	12.5
Kidney	TUHR14TKB	12
Kidney	TUHR4TKB	11.9
Kidney	VMRCRCW	12.1
Kidney	VMRCRCZ	12.4
Large intestine	C2BBE1	12
Large intestine	CCK81	12.8
Large intestine	CL11	13
Large intestine	CL14	11.9
Large intestine	CL34	12.3
Large intestine	CL40	11.6
Large intestine	COLO205	12.2
Large intestine	COLO320	12.6
Large intestine	COLO678	12.6
Large intestine	CW2	11.7
Large intestine	DLD1	12.4
Large intestine	GP2D	12.1
Large intestine	HCC56	12.3
Large intestine	HCT116	12.7
Large intestine	HCT15	12.4
Large intestine	HS675T	11.4
Large intestine	HS698T	11.1
Large intestine	HT115	12.4
Large intestine	HT29	12.5
Large intestine	HT55	12.1
Large intestine	KM12	12.7
Large intestine	LOVO	12.9
Large intestine	LS1034	12.5
Large intestine	LS123	12.6
Large intestine	LS180	12.3
Large intestine	LS411N	12.4
Large intestine	LS513	12.9
Large intestine	MDST8	11.9
Large intestine	NCIH508	11.6
Large intestine	NCIH716	12.8
Large intestine	NCIH747	13
Large intestine	OUMS23	11.8
Large intestine	RCM1	12
Large intestine	RKO	12.9
Large intestine	SKCO1	11.6
Large intestine	SNU1040	11.9
Large intestine	SNU1197	12
Large intestine	SNU175	12.7
Large intestine	SNU283	12.4
Large intestine	SNU407	12.2
Large intestine	SNU503	12.3
Large intestine	SNU61	12.5
Large intestine	SNU81	11.7
Large intestine	SNUC1	12.3
Large intestine	SNUC2A	11.9
Large intestine	SNUC4	12.1
Large intestine	SNUC5	12.7
Large intestine	SW1116	12.1
Large intestine	SW1417	12.8
Large intestine	SW1463	12
Large intestine	SW403	12.7
Large intestine	SW480	12.6
Large intestine	SW48	12.7
Large intestine	SW620	12.6
Large intestine	SW837	12.4
Large intestine	SW948	12.8
Large intestine	T84	12.7
Liver	ALEXANDERCELLS	11.8
Liver	C3A	11.7
Liver	HEP3B217	13.1
Liver	HEPG2	11.5
Liver	HLE	12.5
Liver	HLF	12.4
Liver	HUH1	11.5
Liver	HUH6	12.6
Liver	HUH7	11.9
Liver	JHH1	11.5
Liver	JHH2	12
Liver	JHH4	12.8
Liver	JHH5	12.1
Liver	JHH6	12.3
Liver	JHH7	12.1
Liver	LI7	12
Liver	PLCPRF5	11.8
Liver	SKHEP1	12.4
Liver	SNU182	12.1
Liver	SNU387	12.1
Liver	SNU398	11.3
Liver	SNU423	12
Liver	SNU449	11.8
Liver	SNU475	11.9
Liver	SNU761	12.7
Liver	SNU878	12
Liver	SNU886	12.5
Lung	A549	12
Lung	ABC1	12.8
Lung	BEN	11.4
Lung	CAL12T	12
Lung	CALU1	12.3
Lung	CALU3	12.7
Lung	CALU6	12.1
Lung	CHAGOK1	12.3
Lung	COLO668	13
Lung	COLO699	12.5
Lung	CORL105	12.2
Lung	CORL23	12.2
Lung	CORL24	12.2
Lung	CORL279	12.7
Lung	CORL311	12.7
Lung	CORL47	12.4
Lung	CORL51	12.1
Lung	CORL88	12.6
Lung	CORL95	12.1
Lung	CPCN	12.9
Lung	DMS114	12.5
Lung	DMS153	12.7
Lung	DMS273	12.4
Lung	DMS454	11.8
Lung	DMS53	12.6
Lung	DMS79	12.8
Lung	DV90	12.3
Lung	EBC1	12.4
Lung	EPLC272H	12.3
Lung	HARA	12.3
Lung	HCC1171	12.3
Lung	HCC1195	11.8
Lung	HCC15	12.2
Lung	HCC2279	12.2
Lung	HCC2935	12.2
Lung	HCC33	13
Lung	HCC366	12.6
Lung	HCC4006	12.8
Lung	HCC44	12.3
Lung	HCC78	12.3
Lung	HCC827	12.4
Lung	HCC95	12.5
Lung	HLC1	11.9
Lung	HLFA	11.4
Lung	HS229T	12.2
Lung	HS618T	11.5
Lung	IALM	11.5
Lung	KNS62	12.1
Lung	LC1F	12.3
Lung	LC1SQSF	12.1
Lung	LCLC103H	11.6
Lung	LCLC97TM1	12.5
Lung	LK2	12.4
Lung	LOUNH91	12
Lung	LU65	12.9
Lung	LU99	12.7
Lung	LUDLU1	12.2
Lung	LXF289	12.2
Lung	MORCPR	12.1
Lung	NCIH1048	12.8
Lung	NCIH1092	13.1
Lung	NCIH1105	13
Lung	NCIH1155	13
Lung	NCIH1184	13.2
Lung	NCIH1299	11.8
Lung	NCIH1339	12.4
Lung	NCIH1341	12.8
Lung	NCIH1355	11.9
Lung	NCIH1373	11.7
Lung	NCIH1385	11.7
Lung	NCIH1395	11.7
Lung	NCIH1435	12.1
Lung	NCIH1436	12.5
Lung	NCIH1437	12.1
Lung	NCIH146	12.7
Lung	NCIH1563	12
Lung	NCIH1568	12.4
Lung	NCIH1573	11.3
Lung	NCIH1581	12.7
Lung	NCIH1618	12.7
Lung	NCIH1623	12.4
Lung	NCIH1648	12.1
Lung	NCIH1650	12.7
Lung	NCIH1651	12
Lung	NCIH1666	12.2
Lung	NCIH1693	12.6
Lung	NCIH1694	12.6
Lung	NCIH1703	12.5
Lung	NCIH1734	12.6
Lung	NCIH1755	12.3
Lung	NCIH1781	12.5
Lung	NCIH1792	11.5
Lung	NCIH1793	11.7
Lung	NCIH1836	12.1
Lung	NCIH1838	12.2
Lung	NCIH1869	12.4
Lung	NCIH1876	12.5
Lung	NCIH1915	12.8
Lung	NCIH1930	12.4
Lung	NCIH1944	12.6
Lung	NCIH1963	12.8
Lung	NCIH196	12
Lung	NCIH1975	12.4
Lung	NCIH2009	12
Lung	NCIH2023	12.3
Lung	NCIH2029	12.5
Lung	NCIH2030	11.7
Lung	NCIH2066	11.8
Lung	NCIH2081	12.5
Lung	NCIH2085	12.4
Lung	NCIH2087	12.3
Lung	NCIH209	12.5
Lung	NCIH2106	13.2
Lung	NCIH2110	12.8
Lung	NCIH211	12.7
Lung	NCIH2122	11.8
Lung	NCIH2126	11.8
Lung	NCIH2141	12.4
Lung	NCIH2170	12.4
Lung	NCIH2171	12
Lung	NCIH2172	12.1
Lung	NCIH2196	12.2
Lung	NCIH2227	12.2
Lung	NCIH2228	12.5
Lung	NCIH226	12.6
Lung	NCIH2286	12.4
Lung	NCIH2291	12.3
Lung	NCIH2342	12.3
Lung	NCIH2347	12.3
Lung	NCIH23	12.3
Lung	NCIH2405	12.3
Lung	NCIH2444	12.4
Lung	NCIH292	12.4
Lung	NCIH322	12.4
Lung	NCIH3255	12.4
Lung	NCIH358	12.2
Lung	NCIH441	11.6
Lung	NCIH446	12.4
Lung	NCIH460	12.5
Lung	NCIH510	12.3
Lung	NCIH520	12.1
Lung	NCIH522	12.7
Lung	NCIH524	12.5
Lung	NCIH526	12.4
Lung	NCIH596	12.4
Lung	NCIH647	11.4
Lung	NCIH650	12
Lung	NCIH661	12.5
Lung	NCIH69	12.9
Lung	NCIH727	11.5
Lung	NCIH810	12.8
Lung	NCIH82	12.5
Lung	NCIH838	12.8
Lung	NCIH841	12.4
Lung	NCIH854	11.3
Lung	NCIH889	12.4
Lung	PC14	12.6
Lung	RERFLCAD1	12.4
Lung	RERFLCAD2	12.2
Lung	RERFLCAI	12.4
Lung	RERFLCKJ	12
Lung	RERFLCMS	12.3
Lung	RERFLCSQ1	11.9
Lung	SBC5	12.1
Lung	SCLC21H	12.9
Lung	SHP77	12.2
Lung	SKLU1	12.1
Lung	SKMES1	12.3
Lung	SQ1	12.4
Lung	SW1271	11.9
Lung	SW1573	12.3
Lung	SW900	11.9
Lung	VMRCLCD	12.2
Lung	VMRCLCP	11.9
Oesophagus	COLO680N	11.9
Oesophagus	ECGI10	11.6
Oesophagus	KYSE140	12.8
Oesophagus	KYSE150	12.5
Oesophagus	KYSE180	12.6
Oesophagus	KYSE270	11.7
Oesophagus	KYSE30	12
Oesophagus	KYSE410	12.3
Oesophagus	KYSE450	12.2
Oesophagus	KYSE510	12.3
Oesophagus	KYSE520	12.7
Oesophagus	KYSE70	11.9
Oesophagus	OE19	11.7
Oesophagus	OE33	12.9
Oesophagus	TE10	12.1
Oesophagus	TE11	12.3
Oesophagus	TE14	11.9
Oesophagus	TE15	12.2
Oesophagus	TE1	12.8
Oesophagus	TE4	12.4
Oesophagus	TE5	11.2
Oesophagus	TE6	12.5
Oesophagus	TE8	12.5
Oesophagus	TE9	12
Oesophagus	TT	11.9
Ovary	59M	12.1
Ovary	A2780	12.3
Ovary	CAOV3	11.1
Ovary	CAOV4	11.9
Ovary	COLO704	12.8
Ovary	COV318	11.7
Ovary	COV362	12.7
Ovary	COV434	12.3
Ovary	COV504	12.2
Ovary	COV644	12.1
Ovary	EFO21	11.8
Ovary	EFO27	11.7
Ovary	ES2	12.5
Ovary	FUOV1	11.8
Ovary	HEYA8	12.4
Ovary	HS571T	10.5
Ovary	IGROV1	11.8
Ovary	JHOC5	11.9
Ovary	JHOM1	11.3
Ovary	JHOM2B	12.8
Ovary	JHOS2	12.1
Ovary	JHOS4	12
Ovary	KURAMOCHI	11.2
Ovary	MCAS	11.7
Ovary	NIHOVCAR3	12.1
Ovary	OAW28	11.6
Ovary	OAW42	11.8
Ovary	OC314	12
Ovary	OC316	12.1
Ovary	ONCODG1	12.2
Ovary	OV56	11.5
Ovary	OV7	11.9
Ovary	OV90	12
Ovary	OVCAR4	12.4
Ovary	OVCAR8	12.3
Ovary	OVISE	11.9
Ovary	OVK18	11.8
Ovary	OVKATE	12.4
Ovary	OVMANA	11.6
Ovary	OVSAHO	11.3
Ovary	OVTOKO	12
Ovary	RMGI	10.6
Ovary	RMUGS	12
Ovary	SKOV3	11.5
Ovary	SNU119	12.6
Ovary	SNU840	12.1
Ovary	SNU8	12.3
Ovary	TOV112D	11.7
Ovary	TOV21G	11.6
Ovary	TYKNU	12.5
Pancreas	ASPC1	11.8
Pancreas	BXPC3	11.9
Pancreas	CAPAN1	12.2
Pancreas	CAPAN2	11.7
Pancreas	CFPAC1	11.8
Pancreas	DANG	12.1
Pancreas	HPAC	11.9
Pancreas	HPAFII	12
Pancreas	HS766T	11.4
Pancreas	HUPT3	12
Pancreas	HUPT4	12.2
Pancreas	KCIMOH1	12.3
Pancreas	KLM1	12.2
Pancreas	KP2	12.5
Pancreas	KP3	12.2
Pancreas	KP4	12.4
Pancreas	L33	11.7
Pancreas	MIAPACA2	12.2
Pancreas	PANC0203	12.5
Pancreas	PANC0213	11.3
Pancreas	PANC0327	12.5
Pancreas	PANC0403	12.2
Pancreas	PANC0504	12.1
Pancreas	PANC0813	11.7
Pancreas	PANC1005	12.3
Pancreas	PANC1	12.7
Pancreas	PATU8902	12.6
Pancreas	PATU8988S	12.4
Pancreas	PATU8988T	12.3
Pancreas	PK1	12.3
Pancreas	PK45H	12.9
Pancreas	PK59	11.4
Pancreas	PL45	12.5
Pancreas	PSN1	12
Pancreas	QGP1	12
Pancreas	SNU213	12.2
Pancreas	SNU324	12.5
Pancreas	SNU410	12.5
Pancreas	SU8686	11.7
Pancreas	SUIT2	12.6
Pancreas	SW1990	12.6
Pancreas	T3M4	12.4
Pancreas	TCCPAN2	11.9
Pancreas	YAPC	12.3
Pleura	ACCMESO1	12.9
Pleura	DM3	11.1
Pleura	ISTMES1	12.5
Pleura	ISTMES2	12.1
Pleura	JL1	12.1
Pleura	MPP89	12
Pleura	MSTO211H	12.3
Pleura	NCIH2052	11.5
Pleura	NCIH2452	12.2
Pleura	NCIH28	12.3
Prostate	22RV1	12.6
Prostate	DU145	12.4
Prostate	LNCAPCLONEFGC	12.3
Prostate	MDAPCA2B	11.9
Prostate	NCIH660	12.6
Prostate	PC3	12
Prostate	VCAP	12.4
Salivary gland	A253	12.6
Salivary gland	YD15	12.3
Skin	A101D	12.5
Skin	A2058	12.8
Skin	A375	12.6
Skin	C32	12.4
Skin	CHL1	12.6
Skin	CJM	11.9
Skin	COLO679	12.2
Skin	COLO741	12.5
Skin	COLO783	12.5
Skin	COLO792	12
Skin	COLO800	12.5
Skin	COLO818	13.1
Skin	COLO829	12.4
Skin	COLO849	12.4
Skin	G361	12.8
Skin	GRM	11.7
Skin	HMCB	12.8
Skin	HS294T	12.2
Skin	HS600T	11.4
Skin	HS688AT	11.4
Skin	HS695T	12.6
Skin	HS839T	11.5
Skin	HS852T	13.8
Skin	HS895T	11.8
Skin	HS934T	11.7
Skin	HS936T	11.9
Skin	HS939T	12.8
Skin	HS940T	11.1
Skin	HS944T	11.6
Skin	HT144	12.7
Skin	IGR1	12.3
Skin	IGR37	12.5
Skin	IGR39	12.1
Skin	IPC298	12.3
Skin	K029AX	12.2
Skin	LOXIMVI	12
Skin	MALME3M	12.3
Skin	MDAMB435S	12.3
Skin	MELHO	12.4
Skin	MELJUSO	12.6
Skin	MEWO	12.4
Skin	RPMI7951	12.5
Skin	RVH421	12.5
Skin	SH4	11.7
Skin	SKMEL1	12.1
Skin	SKMEL24	11.7
Skin	SKMEL28	12.2
Skin	SKMEL2	12.5
Skin	SKMEL30	12
Skin	SKMEL31	12.7
Skin	SKMEL3	12.3
Skin	SKMEL5	12.5
Skin	UACC257	12.3
Skin	UACC62	12.4
Skin	WM115	13
Skin	WM1799	12.6
Skin	WM2664	12.9
Skin	WM793	12.9
Skin	WM88	12.8
Skin	WM983B	12.7
Small intestine	HUTU80	12.3
Soft tissue	A204	12.4
Soft tissue	G401	12.2
Soft tissue	G402	12.2
Soft tissue	GCT	11.8
Soft tissue	HS729	12.2
Soft tissue	HT1080	12.1
Soft tissue	KYM1	12.3
Soft tissue	MESSA	11
Soft tissue	RD	12.5
Soft tissue	RH30	11.6
Soft tissue	RH41	12.4
Soft tissue	RKN	12.1
Soft tissue	S117	12.1
Soft tissue	SJRH30	12.4
Soft tissue	SKLMS1	12
Soft tissue	SKUT1	12.2
Soft tissue	TE125T	11.6
Soft tissue	TE159T	11.3
Soft tissue	TE441T	12.3
Soft tissue	TE617T	11.9
Stomach	2313287	11.8
Stomach	AGS	12.1
Stomach	AZ521	12.4
Stomach	ECC10	12.8
Stomach	ECC12	12.4
Stomach	FU97	11.8
Stomach	GCIY	12.6
Stomach	GSS	12.9
Stomach	GSU	12.2
Stomach	HGC27	12.8
Stomach	HS746T	12.4
Stomach	HUG1N	12.4
Stomach	IM95	12.4
Stomach	KATOIII	12.6
Stomach	KE39	11.8
Stomach	LMSU	12.5
Stomach	MKN1	12.5
Stomach	MKN45	12.8
Stomach	MKN74	11.6
Stomach	MKN7	12.6
Stomach	NCCSTCK140	12.2
Stomach	NCIN87	11.8
Stomach	NUGC2	11.7
Stomach	NUGC3	12.2
Stomach	NUGC4	12.5
Stomach	OCUM1	12.3
Stomach	RERFGC1B	12.5
Stomach	SH10TC	12.2
Stomach	SNU16	12.1
Stomach	SNU1	12.3
Stomach	SNU216	12.2
Stomach	SNU520	12.7
Stomach	SNU5	12.4
Stomach	SNU601	12.2
Stomach	SNU620	12.2
Stomach	SNU668	12.2
Stomach	SNU719	12.1
Stomach	TGBC11TKB	12.1
Thyroid	8305C	11.3
Thyroid	8505C	12.2
Thyroid	BCPAP	11.4
Thyroid	BHT101	12.5
Thyroid	CAL62	12.1
Thyroid	CGTHW1	12.2
Thyroid	FTC133	12
Thyroid	FTC238	12.5
Thyroid	ML1	12.1
Thyroid	SW579	12.1
Thyroid	TT2609C02	12.4
Thyroid	TT	11.3
Upper aerodigestive tract	BHY	11.9
Upper aerodigestive tract	BICR16	11.7
Upper aerodigestive tract	BICR18	11.7
Upper aerodigestive tract	BICR22	11.2
Upper aerodigestive tract	BICR31	11.6
Upper aerodigestive tract	BICR56	11.6
Upper aerodigestive tract	BICR6	12.1
Upper aerodigestive tract	CAL27	12
Upper aerodigestive tract	CAL33	12.4
Upper aerodigestive tract	DETROIT562	11.9
Upper aerodigestive tract	FADU	12.1
Upper aerodigestive tract	HS840T	11.6
Upper aerodigestive tract	HSC2	12
Upper aerodigestive tract	HSC3	12.3
Upper aerodigestive tract	HSC4	12
Upper aerodigestive tract	PECAPJ15	11.7
Upper aerodigestive tract	PECAPJ34CLONEC12	12.4
Upper aerodigestive tract	PECAPJ41CLONED2	11.8
Upper aerodigestive tract	PECAPJ49	11.6
Upper aerodigestive tract	SCC15	11.7
Upper aerodigestive tract	SCC25	11.7
Upper aerodigestive tract	SCC4	11.9
Upper aerodigestive tract	SCC9	11.4
Upper aerodigestive tract	SNU1076	11.3
Upper aerodigestive tract	SNU1214	12.2
Upper aerodigestive tract	SNU46	11.8
Upper aerodigestive tract	SNU899	11.9
Upper aerodigestive tract	YD10B	12.4
Upper aerodigestive tract	YD38	12.2
Upper aerodigestive tract	YD8	11.8
Urinary tract	5637	11.9
Urinary tract	639V	11.8
Urinary tract	647V	12.5
Urinary tract	BC3C	12
Urinary tract	BFTC905	11.9
Urinary tract	CAL29	12.2
Urinary tract	HS172T	11.7
Urinary tract	HT1197	11.8
Urinary tract	HT1376	11.9
Urinary tract	J82	11.8
Urinary tract	JMSU1	11.3
Urinary tract	KMBC2	11.6
Urinary tract	KU1919	12
Urinary tract	RT11284	12.2
Urinary tract	RT112	11.8
Urinary tract	RT4	12.4
Urinary tract	SCABER	12
Urinary tract	SW1710	12.3
Urinary tract	SW780	12.1
Urinary tract	T24	11.7
Urinary tract	TCCSUP	11.9
Urinary tract	UMUC1	11.9
Urinary tract	UMUC3	12.1
Urinary tract	VMCUB1	11.1

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	83.8
Adrenal gland	135.6
Appendix	153
Bone marrow	114.1
Breast	137.9
Cerebral cortex	106
Cervix, uterine	112.6
Colon	86
Duodenum	121.3
Endometrium	145.1
Epididymis	106.1
Esophagus	66.5
Fallopian tube	114.6
Gallbladder	105.2
Heart muscle	50
Kidney	89.6
Liver	49
Lung	105
Lymph node	191.4
Ovary	109.2
Pancreas	11.2
Parathyroid gland	79.2
Placenta	142.9
Prostate	101.7
Rectum	110.9
Salivary gland	26.4
Seminal vesicle	94.8
Skeletal muscle	29.2
Skin	72.6
Small intestine	124
Smooth muscle	109.2
Spleen	127.8
Stomach	64.8
Testis	203.5
Thyroid gland	104.5
Tonsil	152
Urinary bladder	113.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
24751108	Overexpression	Non-small Cell Lung Carcinoma	CBX3 and CRABP2 expression was markedly increased in lung cancer tissues and especially CRABP2 may be promising candidate genes in lung adenocarcinoma.
24402692	Underexpression	Cervical Carcinoma	The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis were 80.8% and 50%. For CBX3, such expressions were 7.7% and 29.5%, respectively. Results also showed that the expression of Twist was inversely correlated with that of CBX3.
22870217	Overexpression	Osteosarcoma	In addition, consistently higher CBX3 expression in TSC-enriched osteosarcoma cultures was identified.
25961350	Overexpression	Breast Carcinoma	This is accompanied by upregulation of noncoding RNA (ncRNA) elements including X2-inactive specific transcript (XIST) and chromatin remodeling genes, such as chromodomain helicase DNA-binding protein 2 (CHD2) and the chromobox homolog 3 (CBX3), whose products are required for controlling recruitment of protein/protein or DNA/protein interactions.

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.589	4.32e-39	5.2	50	44.8	Gain
BRCA	Breast invasive carcinoma	1075	0.508	1.46e-71	10.2	58.1	31.6	Neutral
CESC	Cervical and endocervical cancers	292	0.397	1.76e-12	8.6	76.4	15.1	Neutral
COAD	Colon adenocarcinoma	449	0.35	2.26e-14	0.4	42.8	56.8	Gain
ESCA	Esophageal carcinoma	183	0.565	8.15e-17	6	27.9	66.1	Gain
GBM	Glioblastoma multiforme	147	0.517	2.05e-11	0.7	19	80.3	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.53	1.64e-38	5.6	57.4	37	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.49	5.38e-33	0.4	67	32.6	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.549	4.35e-24	0.3	40.3	59.4	Gain
LAML	Acute Myeloid Leukemia	166	0.589	7.34e-17	9.6	89.8	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.557	3.21e-43	1	76.2	22.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.358	1.98e-12	4.4	64	31.6	Neutral
LUAD	Lung adenocarcinoma	512	0.477	1.73e-30	5.9	40.6	53.5	Gain
LUSC	Lung squamous cell carcinoma	498	0.569	4.51e-44	13.1	38.6	48.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.683	1.44e-42	32.7	38	29.3	Neutral
PAAD	Pancreatic adenocarcinoma	177	0.111	0.142	1.7	68.4	29.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.335	1.28e-05	0	82.1	17.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.533	2.32e-37	0.6	78.4	21	Neutral
READ	Rectum adenocarcinoma	164	0.333	1.36e-05	0.6	34.8	64.6	Gain
SARC	Sarcoma	255	0.659	4.2e-33	10.6	53.3	36.1	Gain
SKCM	Skin Cutaneous Melanoma	367	0.493	6.81e-24	5.7	38.1	56.1	Gain
STAD	Stomach adenocarcinoma	413	0.519	6.99e-30	3.9	47.2	48.9	Gain
TGCT	Testicular Germ Cell Tumors	150	0.456	4.71e-09	1.3	15.3	83.3	Gain
THCA	Thyroid carcinoma	497	0.13	0.00373	0	96.4	3.6	Neutral
THYM	Thymoma	119	0.129	0.161	2.5	85.7	11.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.355	2.28e-17	8.8	76.4	14.9	Neutral

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.103	0.0341	17	408	-0.001	0.297	NS/NA
BRCA	Breast invasive carcinoma	-0.12	0.000379	83	785	-0.01	1.89e-08	NS/NA
CESC	Cervical and endocervical cancers	-0.005	0.929	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.089	0.115	19	297	0.002	0.00129	NS/NA
ESCA	Esophageal carcinoma	-0.082	0.257	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.102	0.417	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.224	1.53e-07	20	522	-0.005	0.111	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.062	0.254	24	319	0.002	0.713	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.149	0.0101	23	275	-0.042	0.0813	NS/NA
LAML	Acute Myeloid Leukemia	-0.013	0.863	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.045	0.296	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.2	4.14e-05	41	373	-0.009	0.0326	NS/NA
LUAD	Lung adenocarcinoma	-0.084	0.0657	21	456	0.004	0.678	NS/NA
LUSC	Lung squamous cell carcinoma	-0.052	0.312	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.233	0.552	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.092	0.215	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.119	0.106	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.177	4.02e-05	35	498	-0.003	0.0154	NS/NA
READ	Rectum adenocarcinoma	-0.073	0.466	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.108	0.0814	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.136	0.0031	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.119	0.0213	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.397	3.76e-07	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.095	0.0251	50	509	-0.009	0.00102	NS/NA
THYM	Thymoma	-0.506	4.48e-09	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.039	0.403	34	431	-0.001	0.0347	NS/NA

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	1	Low
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	2	Medium
Hippocampus	2	Medium
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	1	Low
Placenta	2	Medium
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	1	Low
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	2	Medium
Tonsil	2	Medium
Urinary bladder	2	Medium
Vagina	2	Medium

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.841	NS	24476821
BRCA	Breast invasive carcinoma	521	2.62e-13	Significant	23000897
COAD	Colon adenocarcinoma	149	0.072	NS	22810696
GBM	Glioblastoma multiforme	157	0.305	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000444	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	4.44e-05	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.0711	NS	26824661
LUAD	Lung adenocarcinoma	230	3.18e-10	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0983	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00209	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0254	Significant	26544944
READ	Rectum adenocarcinoma	67	0.437	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00261	Significant	26091043
STAD	Stomach adenocarcinoma	277	5.09e-09	Significant	25079317
THCA	Thyroid carcinoma	391	4.84e-33	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0221	Significant	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.901	0.628	NS
BRCA	Breast invasive carcinoma	1079	1.276	0.298	NS
CESC	Cervical and endocervical cancers	291	1.305	0.431	NS
COAD	Colon adenocarcinoma	439	0.971	0.918	NS
ESCA	Esophageal carcinoma	184	1.396	0.3	NS
GBM	Glioblastoma multiforme	158	1.229	0.419	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.464	0.0629	NS
KIRC	Kidney renal clear cell carcinoma	531	1.976	0.00212	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.632	0.218	NS
LAML	Acute Myeloid Leukemia	149	0.853	0.589	NS
LGG	Brain Lower Grade Glioma	511	1.563	0.0603	NS
LIHC	Liver hepatocellular carcinoma	365	2.521	9.89e-05	Shorter
LUAD	Lung adenocarcinoma	502	2.163	0.000365	Shorter
LUSC	Lung squamous cell carcinoma	494	0.876	0.489	NS
OV	Ovarian serous cystadenocarcinoma	303	0.788	0.256	NS
PAAD	Pancreatic adenocarcinoma	177	2.636	0.00113	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	625418691.416	0.305	NS
PRAD	Prostate adenocarcinoma	497	2.754	0.353	NS
READ	Rectum adenocarcinoma	159	0.737	0.589	NS
SARC	Sarcoma	259	2.059	0.0118	Shorter
SKCM	Skin Cutaneous Melanoma	459	0.862	0.415	NS
STAD	Stomach adenocarcinoma	388	0.866	0.523	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.124	NS
THCA	Thyroid carcinoma	500	0.525	0.315	NS
THYM	Thymoma	119	0	0.0729	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.43	0.273	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.03	0.541	NS
BRCA	Breast invasive carcinoma	1071	0.031	0.311	NS
CESC	Cervical and endocervical cancers	167	-0.193	0.0126	Lower
COAD	Colon adenocarcinoma	445	0.063	0.187	NS
ESCA	Esophageal carcinoma	162	0.021	0.788	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.033	0.48	NS
KIRC	Kidney renal clear cell carcinoma	531	0.255	2.65e-09	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.056	0.37	NS
LIHC	Liver hepatocellular carcinoma	347	0.225	2.42e-05	Higher
LUAD	Lung adenocarcinoma	507	0.11	0.0133	Higher
LUSC	Lung squamous cell carcinoma	497	-0.038	0.393	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.096	0.0968	NS
PAAD	Pancreatic adenocarcinoma	176	0.143	0.058	NS
READ	Rectum adenocarcinoma	156	0.148	0.0651	NS
SKCM	Skin Cutaneous Melanoma	410	0.041	0.413	NS
STAD	Stomach adenocarcinoma	392	0	0.997	NS
TGCT	Testicular Germ Cell Tumors	81	-0.292	0.00825	Lower
THCA	Thyroid carcinoma	499	0.09	0.0436	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.123	0.00601	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.171	0.00459	Higher
HNSC	Head and Neck squamous cell carcinoma	498	0.079	0.0783	NS
KIRC	Kidney renal clear cell carcinoma	525	0.258	2e-09	Higher
LGG	Brain Lower Grade Glioma	514	0.198	6.05e-06	Higher
LIHC	Liver hepatocellular carcinoma	366	0.291	1.45e-08	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.014	0.816	NS
PAAD	Pancreatic adenocarcinoma	176	0.186	0.0136	Higher
STAD	Stomach adenocarcinoma	406	-0.122	0.0142	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.299	1.76e-12	Higher

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for CBX3.

Summary
Symbol	CBX3
Name	chromobox 3
Aliases	HP1Hs-gamma; HP1 gamma homolog (Drosophila); chromobox homolog 3 (Drosophila HP1 gamma); HECH; HP1-GAMMA; HP ......
Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25499959	Gastric Cardia Adenocarcinoma	partner	C15orf57	Fusion	Moreover, we firstly discovered 3 fusion genes in GCA, including BMX-ARHGAP, LRP5- LITAF and CBX3-C15orf57.
24402692	Cervical Carcinoma	partner	Twist	Negative correlation	Results also showed that the expression of Twist was inversely correlated with that of CBX3. Moreover, the knockdown of Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescence CBX3 and senescence-associated β-galactosidase activity.