CR2Cancer

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF17218 CBX family C-terminal motif
PF00385 Chromo (CHRromatin Organisation MOdifier) domain

Function

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K9me3	#	21047797

> Gene Ontology [ TOP ]
Biological Process	GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification
Molecular Function	GO:0003682 chromatin binding GO:0003714 transcription corepressor activity GO:0003727 single-stranded RNA binding GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0019789 SUMO transferase activity GO:0032182 ubiquitin-like protein binding GO:0032183 SUMO binding GO:0035064 methylated histone binding GO:0042393 histone binding GO:0051219 phosphoprotein binding
Cellular Component	GO:0000151 ubiquitin ligase complex GO:0000152 nuclear ubiquitin ligase complex GO:0016604 nuclear body GO:0016607 nuclear speck GO:0031519 PcG protein complex GO:0035102 PRC1 complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-392499: Metabolism of proteins R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-4570464: SUMOylation of RNA binding proteins

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-392499: Metabolism of proteins
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-597592: Post-translational protein modification
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-4570464: SUMOylation of RNA binding proteins

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4597323	c.712A>C	p.K238Q	Substitution - Missense	Upper_aerodigestive_tract
COSM3820852	c.198G>T	p.L66L	Substitution - coding silent	Breast
COSM4971875	c.1514_1515insGGCGGC	p.A510_P511insAA	Insertion - In frame	Central_nervous_system
COSM106843	c.971C>T	p.P324L	Substitution - Missense	Skin
COSM3721155	c.1630G>A	p.D544N	Substitution - Missense	Upper_aerodigestive_tract
COSM1666833	c.1514T>C	p.V505A	Substitution - Missense	Eye
COSM309883	c.1008C>G	p.S336R	Substitution - Missense	Soft_tissue
COSM5779578	c.704C>T	p.P235L	Substitution - Missense	Breast
COSM1723044	c.1198_1200delCAC	p.H400delH	Deletion - In frame	Upper_aerodigestive_tract
COSM1130127	c.657T>G	p.G219G	Substitution - coding silent	Liver
COSM4971875	c.1514_1515insGGCGGC	p.A510_P511insAA	Insertion - In frame	Haematopoietic_and_lymphoid_tissue
COSM2802818	c.1452delC	p.E486fs*8	Deletion - Frameshift	Large_intestine
COSM3820850	c.630G>A	p.A210A	Substitution - coding silent	Breast
COSM5972473	c.533A>G	p.K178R	Substitution - Missense	Upper_aerodigestive_tract
COSM5031212	c.142A>G	p.I48V	Substitution - Missense	Pancreas
COSM1666833	c.1514T>C	p.V505A	Substitution - Missense	Soft_tissue
COSM1386961	c.220C>T	p.P74S	Substitution - Missense	Large_intestine
COSM4621429	c.457C>G	p.Q153E	Substitution - Missense	Large_intestine
COSM4151784	c.707C>T	p.A236V	Substitution - Missense	Kidney
COSM1130127	c.657T>G	p.G219G	Substitution - coding silent	Thymus
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM4070317	c.333G>A	p.A111A	Substitution - coding silent	Stomach
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM1386960	c.690delC	p.N231fs*3	Deletion - Frameshift	Large_intestine
COSM290239	c.555C>T	p.C185C	Substitution - coding silent	Large_intestine
COSM1723044	c.1198_1200delCAC	p.H400delH	Deletion - In frame	Upper_aerodigestive_tract
COSM4390338	c.583C>G	p.P195A	Substitution - Missense	Urinary_tract
COSM1199735	c.694G>A	p.G232R	Substitution - Missense	Large_intestine
COSM1745448	c.656_657insGGG	p.G219_A220insG	Insertion - In frame	Urinary_tract
COSM4467607	c.1499C>T	p.S500L	Substitution - Missense	Skin
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM3712468	c.1671C>A	p.Y557*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM3890609	c.689C>T	p.P230L	Substitution - Missense	Skin
COSM562918	c.1502C>T	p.A501V	Substitution - Missense	Large_intestine
COSM4467114	c.1470C>T	p.S490S	Substitution - coding silent	Skin
COSM5364056	c.853G>T	p.A285S	Substitution - Missense	Large_intestine
COSM985410	c.890G>A	p.R297Q	Substitution - Missense	Endometrium
COSM4597323	c.712A>C	p.K238Q	Substitution - Missense	Upper_aerodigestive_tract
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM3523242	c.842C>T	p.S281F	Substitution - Missense	Skin
COSM1386960	c.690delC	p.N231fs*3	Deletion - Frameshift	Large_intestine
COSM3668071	c.1560C>A	p.A520A	Substitution - coding silent	Liver
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM3755973	c.480C>T	p.H160H	Substitution - coding silent	Thyroid
COSM6002627	c.827C>T	p.A276V	Substitution - Missense	Prostate
COSM3712468	c.1671C>A	p.Y557*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM4669566	c.1587G>T	p.S529S	Substitution - coding silent	Large_intestine
COSM3989399	c.1555C>G	p.P519A	Substitution - Missense	Kidney
COSM309883	c.1008C>G	p.S336R	Substitution - Missense	Lung
COSM5028381	c.540G>A	p.A180A	Substitution - coding silent	Breast
COSM4568014	c.970_971CC>TT	p.P324L	Substitution - Missense	Skin
COSM1130127	c.657T>G	p.G219G	Substitution - coding silent	Prostate
COSM5473962	c.1262G>A	p.R421H	Substitution - Missense	Large_intestine
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Soft_tissue
COSM4669568	c.1158G>A	p.P386P	Substitution - coding silent	Large_intestine
COSM4528571	c.1548G>A	p.E516E	Substitution - coding silent	Skin
COSM5783837	c.280A>T	p.T94S	Substitution - Missense	Breast
COSM1666833	c.1514T>C	p.V505A	Substitution - Missense	Stomach
COSM4591511	c.670G>A	p.G224S	Substitution - Missense	Upper_aerodigestive_tract
COSM3523241	c.873C>T	p.S291S	Substitution - coding silent	Skin
COSM4597323	c.712A>C	p.K238Q	Substitution - Missense	Upper_aerodigestive_tract
COSM1247403	c.1289C>T	p.A430V	Substitution - Missense	Oesophagus
COSM4597323	c.712A>C	p.K238Q	Substitution - Missense	Upper_aerodigestive_tract
COSM3691901	c.1520C>T	p.A507V	Substitution - Missense	Large_intestine
COSM4747512	c.1219_1220delTC	p.S407fs*39	Deletion - Frameshift	Stomach
COSM3735164	c.657_669del13	p.G222fs*8	Deletion - Frameshift	Skin
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM985411	c.792C>T	p.I264I	Substitution - coding silent	Endometrium
COSM395660	c.1455G>A	p.G485G	Substitution - coding silent	Lung
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Skin
COSM5415440	c.813G>T	p.E271D	Substitution - Missense	Prostate
COSM985413	c.685C>A	p.P229T	Substitution - Missense	Endometrium
COSM3523243	c.127G>T	p.E43*	Substitution - Nonsense	Skin
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM1386957	c.900C>T	p.D300D	Substitution - coding silent	Large_intestine
COSM5387552	c.1638C>T	p.T546T	Substitution - coding silent	Skin
COSM110355	c.970C>T	p.P324S	Substitution - Missense	Liver
COSM417946	c.181G>A	p.E61K	Substitution - Missense	Urinary_tract
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM3388267	c.1439C>T	p.T480M	Substitution - Missense	Pancreas
COSM1723044	c.1198_1200delCAC	p.H400delH	Deletion - In frame	Upper_aerodigestive_tract
COSM1191100	c.1167_1168insCAC	p.H400_A401insH	Insertion - In frame	Thyroid
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4970101	c.1014G>A	p.P338P	Substitution - coding silent	Central_nervous_system
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM4469555	c.1604C>T	p.P535L	Substitution - Missense	Skin
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Soft_tissue
COSM4462952	c.1269C>G	p.P423P	Substitution - coding silent	Skin
COSM5364056	c.853G>T	p.A285S	Substitution - Missense	Large_intestine
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM3773328	c.1497G>T	p.A499A	Substitution - coding silent	Pancreas
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Soft_tissue
COSM5741171	c.298T>C	p.S100P	Substitution - Missense	Small_intestine
COSM356859	c.1456G>T	p.E486*	Substitution - Nonsense	Lung
COSM110355	c.970C>T	p.P324S	Substitution - Missense	Skin
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM1666833	c.1514T>C	p.V505A	Substitution - Missense	Central_nervous_system
COSM5343047	c.1586C>T	p.S529L	Substitution - Missense	Large_intestine
COSM5772519	c.323A>C	p.D108A	Substitution - Missense	Breast
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3672610	c.342G>A	p.K114K	Substitution - coding silent	Prostate
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Thyroid
COSM1386956	c.1523_1524insGGCGGC	p.A510_P511insAA	Insertion - In frame	Large_intestine
COSM1386960	c.690delC	p.N231fs*3	Deletion - Frameshift	Large_intestine
COSM3721156	c.1524A>G	p.A508A	Substitution - coding silent	Oesophagus
COSM4070313	c.1512G>A	p.A504A	Substitution - coding silent	Stomach
COSM1723044	c.1198_1200delCAC	p.H400delH	Deletion - In frame	Upper_aerodigestive_tract
COSM4594938	c.108G>T	p.S36S	Substitution - coding silent	Upper_aerodigestive_tract
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM562918	c.1502C>T	p.A501V	Substitution - Missense	Oesophagus
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM133536	c.956_957AG>TC	p.K319I	Substitution - Missense	Ovary
COSM1666833	c.1514T>C	p.V505A	Substitution - Missense	Large_intestine
COSM5046356	c.982A>T	p.R328W	Substitution - Missense	Oesophagus
COSM4070314	c.1511C>T	p.A504V	Substitution - Missense	Stomach
COSM4070316	c.438G>A	p.K146K	Substitution - coding silent	Stomach
COSM4070315	c.706G>A	p.A236T	Substitution - Missense	Stomach
COSM4527037	c.1437G>A	p.K479K	Substitution - coding silent	Skin
COSM4669568	c.1158G>A	p.P386P	Substitution - coding silent	Skin
COSM1386956	c.1523_1524insGGCGGC	p.A510_P511insAA	Insertion - In frame	Large_intestine
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM4591511	c.670G>A	p.G224S	Substitution - Missense	Upper_aerodigestive_tract
COSM4591511	c.670G>A	p.G224S	Substitution - Missense	Upper_aerodigestive_tract
COSM4511622	c.874C>T	p.P292S	Substitution - Missense	Skin
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM985414	c.507C>T	p.Y169Y	Substitution - coding silent	Endometrium
COSM3820853	c.191A>G	p.E64G	Substitution - Missense	Breast
COSM2802815	c.1587G>A	p.S529S	Substitution - coding silent	Large_intestine
COSM1386960	c.690delC	p.N231fs*3	Deletion - Frameshift	Large_intestine
COSM4669565	c.1646G>A	p.C549Y	Substitution - Missense	Large_intestine
COSM4591511	c.670G>A	p.G224S	Substitution - Missense	Upper_aerodigestive_tract
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM985412	c.733G>A	p.G245R	Substitution - Missense	Endometrium
COSM1386956	c.1523_1524insGGCGGC	p.A510_P511insAA	Insertion - In frame	Large_intestine
COSM309882	c.366C>G	p.L122L	Substitution - coding silent	Lung
COSM5578231	c.700A>T	p.M234L	Substitution - Missense	Skin
COSM4804719	c.1392G>T	p.L464L	Substitution - coding silent	Liver
COSM4820610	c.1000G>A	p.G334R	Substitution - Missense	Cervix
COSM1386959	c.690_691insC	p.N231fs*81	Insertion - Frameshift	Breast
COSM239170	c.634A>G	p.K212E	Substitution - Missense	Prostate
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM3668071	c.1560C>A	p.A520A	Substitution - coding silent	Liver
COSM460184	c.1456G>A	p.E486K	Substitution - Missense	Cervix
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM708776	c.1374G>C	p.P458P	Substitution - coding silent	Lung
COSM985414	c.507C>T	p.Y169Y	Substitution - coding silent	Prostate
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM239171	c.212_213delAG	p.G73fs*29	Deletion - Frameshift	Prostate
COSM359142	c.559G>T	p.D187Y	Substitution - Missense	Lung
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM6002627	c.827C>T	p.A276V	Substitution - Missense	Prostate
COSM1191100	c.1167_1168insCAC	p.H400_A401insH	Insertion - In frame	Lung
COSM3721156	c.1524A>G	p.A508A	Substitution - coding silent	Upper_aerodigestive_tract
COSM4400793	c.1421A>G	p.D474G	Substitution - Missense	Skin
COSM3523240	c.1371C>T	p.L457L	Substitution - coding silent	Skin
COSM1723044	c.1198_1200delCAC	p.H400delH	Deletion - In frame	Upper_aerodigestive_tract
COSM4591511	c.670G>A	p.G224S	Substitution - Missense	Upper_aerodigestive_tract
COSM1666833	c.1514T>C	p.V505A	Substitution - Missense	Liver
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM1386959	c.690_691insC	p.N231fs*81	Insertion - Frameshift	Large_intestine
COSM1386958	c.816C>T	p.N272N	Substitution - coding silent	Large_intestine
COSM1666833	c.1514T>C	p.V505A	Substitution - Missense	Liver
COSM985409	c.916G>A	p.A306T	Substitution - Missense	Endometrium
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Soft_tissue
COSM5350420	c.972G>A	p.P324P	Substitution - coding silent	Lung
COSM5493650	c.772_777delAAGAAC	p.K258_N259delKN	Deletion - In frame	Biliary_tract
COSM4456772	c.1020C>T	p.P340P	Substitution - coding silent	Skin
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM3755973	c.480C>T	p.H160H	Substitution - coding silent	Large_intestine
COSM5456652	c.585C>T	p.P195P	Substitution - coding silent	Large_intestine
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM4139920	c.1298T>C	p.I433T	Substitution - Missense	Ovary
COSM5549122	c.650C>T	p.A217V	Substitution - Missense	Prostate
COSM4593173	c.691A>C	p.N231H	Substitution - Missense	Upper_aerodigestive_tract
COSM3820851	c.530A>G	p.H177R	Substitution - Missense	Breast
COSM4669567	c.1561G>A	p.E521K	Substitution - Missense	Large_intestine
COSM1303440	c.759C>G	p.V253V	Substitution - coding silent	Urinary_tract
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM5779506	c.1640C>G	p.A547G	Substitution - Missense	Breast
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM5779959	c.1486G>C	p.E496Q	Substitution - Missense	Breast
COSM1199734	c.822G>A	p.M274I	Substitution - Missense	Large_intestine
COSM5791642	c.768G>C	p.K256N	Substitution - Missense	Breast
COSM6002627	c.827C>T	p.A276V	Substitution - Missense	Prostate
COSM4804719	c.1392G>T	p.L464L	Substitution - coding silent	Liver
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Upper_aerodigestive_tract
COSM4000327	c.871T>C	p.S291P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4591511	c.670G>A	p.G224S	Substitution - Missense	Upper_aerodigestive_tract
COSM1666833	c.1514T>C	p.V505A	Substitution - Missense	Liver
COSM4503324	c.637C>T	p.P213S	Substitution - Missense	Skin
COSM1666833	c.1514T>C	p.V505A	Substitution - Missense	Large_intestine
COSM1303439	c.847G>T	p.E283*	Substitution - Nonsense	Urinary_tract
COSM3932769	c.908A>C	p.H303P	Substitution - Missense	Urinary_tract
COSM4597323	c.712A>C	p.K238Q	Substitution - Missense	Upper_aerodigestive_tract

> Text Mining based Variations [ TOP ]
There is no record for CBX4.

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O00257	182	S	Phosphoserine	-	No	None detected
O00257	467	S	Phosphoserine	-	No	None detected
O00257	497	T	Phosphothreonine	HIPK2	No	None detected

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.485	5.128	0.673	1.87e-05	Over
BRCA	Breast invasive carcinoma	112	1100	3.976	5.492	1.625	9.88e-69	Over
CESC	Cervical and endocervical cancers	3	306	3.242	5.184	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.792	5.285	1.463	6.81e-37	Over
ESCA	Esophageal carcinoma	11	185	4.68	5.389	0.808	0.000132	Over
GBM	Glioblastoma multiforme	5	166	5.42	4.815	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.9	4.906	0.139	0.179	NS
KIRC	Kidney renal clear cell carcinoma	72	534	3.86	4.031	-0.01	0.903	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.267	4.38	0.067	0.583	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.405	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.344	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.247	4.843	0.71	4.05e-10	Over
LUAD	Lung adenocarcinoma	59	517	4.411	5.363	1.045	2.14e-31	Over
LUSC	Lung squamous cell carcinoma	51	501	4.18	5.051	0.96	5.23e-22	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.315	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.959	4.891	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.008	5.457	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.71	5.464	0.805	2.48e-18	Over
READ	Rectum adenocarcinoma	10	167	3.645	5.265	1.693	4.86e-12	Over
SARC	Sarcoma	2	263	3.468	4.607	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.78	6.116	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.916	5.62	0.701	6.34e-07	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.434	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.503	5.157	0.731	2.73e-24	Over
THYM	Thymoma	2	120	5.981	6.173	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.168	4.842	0.767	3.98e-12	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.4
Autonomic ganglia	CHP212	8.5
Autonomic ganglia	IMR32	7.8
Autonomic ganglia	KELLY	8.6
Autonomic ganglia	KPNRTBM1	7.2
Autonomic ganglia	KPNSI9S	8.7
Autonomic ganglia	KPNYN	8.2
Autonomic ganglia	MHHNB11	8.8
Autonomic ganglia	NB1	8
Autonomic ganglia	NH6	8.2
Autonomic ganglia	SHSY5Y	7.8
Autonomic ganglia	SIMA	8.9
Autonomic ganglia	SKNAS	8
Autonomic ganglia	SKNBE2	8
Autonomic ganglia	SKNDZ	7.6
Autonomic ganglia	SKNFI	7.5
Autonomic ganglia	SKNSH	7.5
Biliary tract	HUCCT1	8.3
Biliary tract	HUH28	8.5
Biliary tract	SNU1079	8.6
Biliary tract	SNU1196	9.8
Biliary tract	SNU245	8.9
Biliary tract	SNU308	8.6
Biliary tract	SNU478	7.6
Bone	143B	8.3
Bone	A673	8.2
Bone	CADOES1	9.8
Bone	CAL78	7.7
Bone	G292CLONEA141B1	7.9
Bone	HOS	8
Bone	HS706T	8.2
Bone	HS737T	7.5
Bone	HS819T	7.3
Bone	HS821T	8.7
Bone	HS822T	7.3
Bone	HS863T	7.2
Bone	HS870T	7
Bone	HS888T	7.3
Bone	MG63	8.6
Bone	MHHES1	9.4
Bone	OUMS27	8.2
Bone	RDES	8.1
Bone	SJSA1	8.8
Bone	SKES1	7.7
Bone	SKNMC	8.8
Bone	SW1353	8.4
Bone	T173	7.4
Bone	TC71	8.6
Bone	U2OS	8.5
Breast	AU565	10.3
Breast	BT20	8.2
Breast	BT474	8.4
Breast	BT483	9.7
Breast	BT549	7.2
Breast	CAL120	7.3
Breast	CAL148	8.3
Breast	CAL51	8.2
Breast	CAL851	7.8
Breast	CAMA1	8.3
Breast	DU4475	8.7
Breast	EFM192A	9.5
Breast	EFM19	9.6
Breast	EVSAT	9.7
Breast	HCC1143	8.6
Breast	HCC1187	8.3
Breast	HCC1395	9.1
Breast	HCC1419	10.4
Breast	HCC1428	10.1
Breast	HCC1500	9.8
Breast	HCC1569	7.6
Breast	HCC1599	8.3
Breast	HCC1806	8.7
Breast	HCC1937	8.5
Breast	HCC1954	8.4
Breast	HCC202	10.6
Breast	HCC2157	8.2
Breast	HCC2218	9.4
Breast	HCC38	8.5
Breast	HCC70	9
Breast	HDQP1	7.4
Breast	HMC18	8.6
Breast	HS274T	7.8
Breast	HS281T	7.2
Breast	HS343T	7.5
Breast	HS578T	7.9
Breast	HS606T	7.4
Breast	HS739T	7.4
Breast	HS742T	7.6
Breast	JIMT1	8.9
Breast	KPL1	9.6
Breast	MCF7	9.9
Breast	MDAMB134VI	8.1
Breast	MDAMB157	9
Breast	MDAMB175VII	8.4
Breast	MDAMB231	7.4
Breast	MDAMB361	8.9
Breast	MDAMB415	9.1
Breast	MDAMB436	8
Breast	MDAMB453	8.4
Breast	MDAMB468	9
Breast	SKBR3	10.1
Breast	T47D	8.7
Breast	UACC812	8.5
Breast	UACC893	9
Breast	YMB1	9.8
Breast	ZR751	9.4
Breast	ZR7530	7.4
Central nervous system	1321N1	8.6
Central nervous system	42MGBA	8.4
Central nervous system	8MGBA	8.4
Central nervous system	A172	8.3
Central nervous system	AM38	7.1
Central nervous system	BECKER	8.5
Central nervous system	CAS1	8.3
Central nervous system	CCFSTTG1	9
Central nervous system	D283MED	7.6
Central nervous system	D341MED	9.5
Central nervous system	DAOY	7.2
Central nervous system	DBTRG05MG	7.4
Central nervous system	DKMG	7.8
Central nervous system	GAMG	7.6
Central nervous system	GB1	9.7
Central nervous system	GI1	8.3
Central nervous system	GMS10	8.3
Central nervous system	GOS3	7.9
Central nervous system	H4	9.1
Central nervous system	HS683	8.7
Central nervous system	KALS1	8
Central nervous system	KG1C	8.1
Central nervous system	KNS42	7.5
Central nervous system	KNS60	7
Central nervous system	KNS81	7
Central nervous system	KS1	7.7
Central nervous system	LN18	9
Central nervous system	LN229	9
Central nervous system	M059K	7.7
Central nervous system	MOGGCCM	7.7
Central nervous system	MOGGUVW	8.3
Central nervous system	NMCG1	7.3
Central nervous system	ONS76	8.7
Central nervous system	SF126	8.1
Central nervous system	SF295	8.9
Central nervous system	SNB19	8.1
Central nervous system	SNU1105	7.9
Central nervous system	SNU201	8
Central nervous system	SNU466	8.4
Central nervous system	SNU489	8.9
Central nervous system	SNU626	8.9
Central nervous system	SNU738	7.7
Central nervous system	SW1088	9.1
Central nervous system	SW1783	7.6
Central nervous system	T98G	8.8
Central nervous system	TM31	7.9
Central nervous system	U118MG	8.4
Central nervous system	U138MG	8.4
Central nervous system	U251MG	8.5
Central nervous system	U87MG	7.7
Central nervous system	YH13	8.2
Central nervous system	YKG1	8.5
Endometrium	AN3CA	9.2
Endometrium	COLO684	9.9
Endometrium	EFE184	8
Endometrium	EN	8.2
Endometrium	ESS1	7.1
Endometrium	HEC108	7.9
Endometrium	HEC151	7.7
Endometrium	HEC1A	7.7
Endometrium	HEC1B	8.5
Endometrium	HEC251	7.6
Endometrium	HEC265	6.8
Endometrium	HEC50B	8.5
Endometrium	HEC59	8.5
Endometrium	HEC6	7.6
Endometrium	ISHIKAWAHERAKLIO02ER	8.2
Endometrium	JHUEM1	7.5
Endometrium	JHUEM2	8.2
Endometrium	JHUEM3	7.1
Endometrium	KLE	8.5
Endometrium	MFE280	7.7
Endometrium	MFE296	7.4
Endometrium	MFE319	7.9
Endometrium	RL952	8.5
Endometrium	SNGM	8.2
Endometrium	SNU1077	8
Endometrium	SNU685	7.3
Endometrium	TEN	7.1
Haematopoietic and lymphoid	697	8.6
Haematopoietic and lymphoid	A3KAW	9.7
Haematopoietic and lymphoid	A4FUK	10.2
Haematopoietic and lymphoid	ALLSIL	10.3
Haematopoietic and lymphoid	AML193	9.5
Haematopoietic and lymphoid	AMO1	10.1
Haematopoietic and lymphoid	BCP1	8.5
Haematopoietic and lymphoid	BDCM	7.9
Haematopoietic and lymphoid	BL41	9.2
Haematopoietic and lymphoid	BL70	9.2
Haematopoietic and lymphoid	BV173	10.3
Haematopoietic and lymphoid	CA46	10
Haematopoietic and lymphoid	CI1	8.7
Haematopoietic and lymphoid	CMK115	7.4
Haematopoietic and lymphoid	CMK86	8.3
Haematopoietic and lymphoid	CMK	8.4
Haematopoietic and lymphoid	CMLT1	10.8
Haematopoietic and lymphoid	COLO775	10.2
Haematopoietic and lymphoid	DAUDI	7.5
Haematopoietic and lymphoid	DB	7.5
Haematopoietic and lymphoid	DEL	8.4
Haematopoietic and lymphoid	DND41	10.1
Haematopoietic and lymphoid	DOHH2	9.2
Haematopoietic and lymphoid	EB1	9.1
Haematopoietic and lymphoid	EB2	9.3
Haematopoietic and lymphoid	EHEB	8.5
Haematopoietic and lymphoid	EJM	8.8
Haematopoietic and lymphoid	EM2	9.5
Haematopoietic and lymphoid	EOL1	9
Haematopoietic and lymphoid	F36P	9.5
Haematopoietic and lymphoid	GA10	8.7
Haematopoietic and lymphoid	GDM1	8.3
Haematopoietic and lymphoid	GRANTA519	9
Haematopoietic and lymphoid	HDLM2	6.7
Haematopoietic and lymphoid	HDMYZ	7.6
Haematopoietic and lymphoid	HEL9217	7.3
Haematopoietic and lymphoid	HEL	8
Haematopoietic and lymphoid	HH	8.6
Haematopoietic and lymphoid	HL60	9.1
Haematopoietic and lymphoid	HPBALL	9.4
Haematopoietic and lymphoid	HS604T	7.5
Haematopoietic and lymphoid	HS611T	7.8
Haematopoietic and lymphoid	HS616T	7.7
Haematopoietic and lymphoid	HS751T	7.5
Haematopoietic and lymphoid	HT	7.7
Haematopoietic and lymphoid	HTK	8.6
Haematopoietic and lymphoid	HUNS1	7.8
Haematopoietic and lymphoid	HUT102	7.3
Haematopoietic and lymphoid	HUT78	9.2
Haematopoietic and lymphoid	JEKO1	9.4
Haematopoietic and lymphoid	JK1	7.8
Haematopoietic and lymphoid	JM1	9.2
Haematopoietic and lymphoid	JURKAT	9.8
Haematopoietic and lymphoid	JURLMK1	10.3
Haematopoietic and lymphoid	JVM2	9
Haematopoietic and lymphoid	JVM3	9.8
Haematopoietic and lymphoid	K562	9.9
Haematopoietic and lymphoid	KARPAS299	7.9
Haematopoietic and lymphoid	KARPAS422	8.5
Haematopoietic and lymphoid	KARPAS620	9.3
Haematopoietic and lymphoid	KASUMI1	8.5
Haematopoietic and lymphoid	KASUMI2	8.8
Haematopoietic and lymphoid	KASUMI6	8.1
Haematopoietic and lymphoid	KCL22	9.7
Haematopoietic and lymphoid	KE37	9.7
Haematopoietic and lymphoid	KE97	8.4
Haematopoietic and lymphoid	KG1	8.1
Haematopoietic and lymphoid	KHM1B	9.9
Haematopoietic and lymphoid	KIJK	8
Haematopoietic and lymphoid	KMH2	8.7
Haematopoietic and lymphoid	KMM1	9.2
Haematopoietic and lymphoid	KMS11	9.3
Haematopoietic and lymphoid	KMS12BM	8.7
Haematopoietic and lymphoid	KMS18	9.6
Haematopoietic and lymphoid	KMS20	9.5
Haematopoietic and lymphoid	KMS21BM	9.3
Haematopoietic and lymphoid	KMS26	10
Haematopoietic and lymphoid	KMS27	9.9
Haematopoietic and lymphoid	KMS28BM	9.2
Haematopoietic and lymphoid	KMS34	9.6
Haematopoietic and lymphoid	KO52	8.2
Haematopoietic and lymphoid	KOPN8	9.4
Haematopoietic and lymphoid	KU812	8.4
Haematopoietic and lymphoid	KYO1	9.3
Haematopoietic and lymphoid	L1236	8.6
Haematopoietic and lymphoid	L363	10
Haematopoietic and lymphoid	L428	7.9
Haematopoietic and lymphoid	L540	7.7
Haematopoietic and lymphoid	LAMA84	10.2
Haematopoietic and lymphoid	LOUCY	10
Haematopoietic and lymphoid	LP1	11.2
Haematopoietic and lymphoid	M07E	8.7
Haematopoietic and lymphoid	MC116	8.8
Haematopoietic and lymphoid	ME1	8.1
Haematopoietic and lymphoid	MEC1	8.6
Haematopoietic and lymphoid	MEC2	8.2
Haematopoietic and lymphoid	MEG01	9.9
Haematopoietic and lymphoid	MHHCALL2	8.9
Haematopoietic and lymphoid	MHHCALL3	8.9
Haematopoietic and lymphoid	MHHCALL4	9
Haematopoietic and lymphoid	MINO	8.7
Haematopoietic and lymphoid	MJ	7.3
Haematopoietic and lymphoid	MM1S	7
Haematopoietic and lymphoid	MOLM13	8.6
Haematopoietic and lymphoid	MOLM16	7.5
Haematopoietic and lymphoid	MOLM6	8.9
Haematopoietic and lymphoid	MOLP2	10.5
Haematopoietic and lymphoid	MOLP8	9.6
Haematopoietic and lymphoid	MOLT13	8.7
Haematopoietic and lymphoid	MOLT16	9.9
Haematopoietic and lymphoid	MOLT4	8.4
Haematopoietic and lymphoid	MONOMAC1	8.6
Haematopoietic and lymphoid	MONOMAC6	9.8
Haematopoietic and lymphoid	MOTN1	8.8
Haematopoietic and lymphoid	MUTZ5	10
Haematopoietic and lymphoid	MV411	9.1
Haematopoietic and lymphoid	NALM19	9.3
Haematopoietic and lymphoid	NALM1	9.7
Haematopoietic and lymphoid	NALM6	10.6
Haematopoietic and lymphoid	NAMALWA	9.6
Haematopoietic and lymphoid	NB4	8.4
Haematopoietic and lymphoid	NCIH929	9
Haematopoietic and lymphoid	NCO2	8
Haematopoietic and lymphoid	NOMO1	7.9
Haematopoietic and lymphoid	NUDHL1	9.4
Haematopoietic and lymphoid	NUDUL1	9.3
Haematopoietic and lymphoid	OCIAML2	8.7
Haematopoietic and lymphoid	OCIAML3	10.3
Haematopoietic and lymphoid	OCIAML5	8.7
Haematopoietic and lymphoid	OCILY10	8.7
Haematopoietic and lymphoid	OCILY19	9.6
Haematopoietic and lymphoid	OCILY3	9.8
Haematopoietic and lymphoid	OCIM1	9
Haematopoietic and lymphoid	OPM2	10.6
Haematopoietic and lymphoid	P12ICHIKAWA	9.3
Haematopoietic and lymphoid	P31FUJ	9.3
Haematopoietic and lymphoid	P3HR1	8.5
Haematopoietic and lymphoid	PCM6	8.8
Haematopoietic and lymphoid	PEER	9.5
Haematopoietic and lymphoid	PF382	9.4
Haematopoietic and lymphoid	PFEIFFER	8.5
Haematopoietic and lymphoid	PL21	9.8
Haematopoietic and lymphoid	RAJI	8.2
Haematopoietic and lymphoid	RCHACV	8.2
Haematopoietic and lymphoid	REC1	9.6
Haematopoietic and lymphoid	REH	9.1
Haematopoietic and lymphoid	RI1	9.6
Haematopoietic and lymphoid	RL	7.9
Haematopoietic and lymphoid	RPMI8226	9.1
Haematopoietic and lymphoid	RPMI8402	9.8
Haematopoietic and lymphoid	RS411	8.6
Haematopoietic and lymphoid	SEM	8.2
Haematopoietic and lymphoid	SET2	8.1
Haematopoietic and lymphoid	SIGM5	8.7
Haematopoietic and lymphoid	SKM1	9.1
Haematopoietic and lymphoid	SKMM2	10.4
Haematopoietic and lymphoid	SR786	8.9
Haematopoietic and lymphoid	ST486	9.1
Haematopoietic and lymphoid	SUDHL10	9.2
Haematopoietic and lymphoid	SUDHL1	7.7
Haematopoietic and lymphoid	SUDHL4	9.4
Haematopoietic and lymphoid	SUDHL5	8.7
Haematopoietic and lymphoid	SUDHL6	8.3
Haematopoietic and lymphoid	SUDHL8	9.8
Haematopoietic and lymphoid	SUPB15	9.2
Haematopoietic and lymphoid	SUPHD1	8.8
Haematopoietic and lymphoid	SUPM2	8.8
Haematopoietic and lymphoid	SUPT11	9.9
Haematopoietic and lymphoid	SUPT1	8.6
Haematopoietic and lymphoid	TALL1	9.6
Haematopoietic and lymphoid	TF1	8.2
Haematopoietic and lymphoid	THP1	8.5
Haematopoietic and lymphoid	TO175T	7.7
Haematopoietic and lymphoid	TOLEDO	9.3
Haematopoietic and lymphoid	U266B1	8.8
Haematopoietic and lymphoid	U937	9
Haematopoietic and lymphoid	UT7	8.3
Haematopoietic and lymphoid	WSUDLCL2	9.1
Kidney	769P	7.7
Kidney	786O	7.1
Kidney	A498	9.2
Kidney	A704	6.7
Kidney	ACHN	7.7
Kidney	BFTC909	7.4
Kidney	CAKI1	7.6
Kidney	CAKI2	7.5
Kidney	CAL54	7.9
Kidney	KMRC1	6.6
Kidney	KMRC20	7.3
Kidney	KMRC2	6.7
Kidney	KMRC3	8.5
Kidney	OSRC2	7.9
Kidney	RCC10RGB	6.9
Kidney	SNU1272	6.9
Kidney	SNU349	7.9
Kidney	TUHR10TKB	7.1
Kidney	TUHR14TKB	7.8
Kidney	TUHR4TKB	7.1
Kidney	VMRCRCW	9
Kidney	VMRCRCZ	8.1
Large intestine	C2BBE1	8.7
Large intestine	CCK81	7.9
Large intestine	CL11	8.5
Large intestine	CL14	8.5
Large intestine	CL34	8.4
Large intestine	CL40	8.9
Large intestine	COLO205	9
Large intestine	COLO320	7.2
Large intestine	COLO678	9.2
Large intestine	CW2	8.6
Large intestine	DLD1	8.6
Large intestine	GP2D	7
Large intestine	HCC56	8.1
Large intestine	HCT116	8
Large intestine	HCT15	8
Large intestine	HS675T	7.7
Large intestine	HS698T	7.6
Large intestine	HT115	8.7
Large intestine	HT29	8.2
Large intestine	HT55	8.3
Large intestine	KM12	9.1
Large intestine	LOVO	8.3
Large intestine	LS1034	8.8
Large intestine	LS123	8.6
Large intestine	LS180	8.2
Large intestine	LS411N	8.4
Large intestine	LS513	8
Large intestine	MDST8	8.5
Large intestine	NCIH508	8.8
Large intestine	NCIH716	8.5
Large intestine	NCIH747	8.1
Large intestine	OUMS23	8.2
Large intestine	RCM1	9
Large intestine	RKO	8
Large intestine	SKCO1	8.7
Large intestine	SNU1040	8.5
Large intestine	SNU1197	8.3
Large intestine	SNU175	9.5
Large intestine	SNU283	8.7
Large intestine	SNU407	8.4
Large intestine	SNU503	9.2
Large intestine	SNU61	8.1
Large intestine	SNU81	11.2
Large intestine	SNUC1	8.7
Large intestine	SNUC2A	9
Large intestine	SNUC4	7.9
Large intestine	SNUC5	8.7
Large intestine	SW1116	8.7
Large intestine	SW1417	8.8
Large intestine	SW1463	7.8
Large intestine	SW403	8.5
Large intestine	SW480	7.9
Large intestine	SW48	10.3
Large intestine	SW620	8.8
Large intestine	SW837	8.6
Large intestine	SW948	8
Large intestine	T84	8.9
Liver	ALEXANDERCELLS	8.8
Liver	C3A	8.7
Liver	HEP3B217	8.8
Liver	HEPG2	9.1
Liver	HLE	8.3
Liver	HLF	8
Liver	HUH1	8.4
Liver	HUH6	7.6
Liver	HUH7	8.5
Liver	JHH1	8.2
Liver	JHH2	8.9
Liver	JHH4	8.2
Liver	JHH5	8.8
Liver	JHH6	8.3
Liver	JHH7	8.7
Liver	LI7	9.6
Liver	PLCPRF5	9.5
Liver	SKHEP1	7.8
Liver	SNU182	9.1
Liver	SNU387	8
Liver	SNU398	9.2
Liver	SNU423	7.5
Liver	SNU449	8.5
Liver	SNU475	8.7
Liver	SNU761	8.7
Liver	SNU878	9.1
Liver	SNU886	9.2
Lung	A549	8.6
Lung	ABC1	8.1
Lung	BEN	8.6
Lung	CAL12T	7.6
Lung	CALU1	8
Lung	CALU3	7.7
Lung	CALU6	7.8
Lung	CHAGOK1	9.2
Lung	COLO668	7.7
Lung	COLO699	9
Lung	CORL105	8.9
Lung	CORL23	8
Lung	CORL24	8.1
Lung	CORL279	8.1
Lung	CORL311	8.3
Lung	CORL47	9
Lung	CORL51	8
Lung	CORL88	7.8
Lung	CORL95	8
Lung	CPCN	7.8
Lung	DMS114	8.3
Lung	DMS153	8.5
Lung	DMS273	7.8
Lung	DMS454	8.1
Lung	DMS53	7.2
Lung	DMS79	8.2
Lung	DV90	9.2
Lung	EBC1	8
Lung	EPLC272H	8.3
Lung	HARA	8.4
Lung	HCC1171	8.4
Lung	HCC1195	8.8
Lung	HCC15	7.8
Lung	HCC2279	8.5
Lung	HCC2935	9
Lung	HCC33	7.3
Lung	HCC366	8.2
Lung	HCC4006	8.3
Lung	HCC44	8.2
Lung	HCC78	8.2
Lung	HCC827	7.2
Lung	HCC95	8.4
Lung	HLC1	9.6
Lung	HLFA	7.7
Lung	HS229T	7.5
Lung	HS618T	7.4
Lung	IALM	7.9
Lung	KNS62	9.1
Lung	LC1F	9.7
Lung	LC1SQSF	9.5
Lung	LCLC103H	7.2
Lung	LCLC97TM1	8.8
Lung	LK2	6.9
Lung	LOUNH91	8
Lung	LU65	8.3
Lung	LU99	7
Lung	LUDLU1	8.5
Lung	LXF289	9.3
Lung	MORCPR	10
Lung	NCIH1048	9.1
Lung	NCIH1092	7.9
Lung	NCIH1105	7.2
Lung	NCIH1155	8.5
Lung	NCIH1184	8.4
Lung	NCIH1299	7.8
Lung	NCIH1339	8
Lung	NCIH1341	9.2
Lung	NCIH1355	8.9
Lung	NCIH1373	8.8
Lung	NCIH1385	10.2
Lung	NCIH1395	9.7
Lung	NCIH1435	8.7
Lung	NCIH1436	8.7
Lung	NCIH1437	9.5
Lung	NCIH146	8
Lung	NCIH1563	8.6
Lung	NCIH1568	8
Lung	NCIH1573	8.8
Lung	NCIH1581	8.3
Lung	NCIH1618	8.8
Lung	NCIH1623	9.3
Lung	NCIH1648	8.5
Lung	NCIH1650	8.9
Lung	NCIH1651	8.2
Lung	NCIH1666	8.4
Lung	NCIH1693	7.1
Lung	NCIH1694	8.7
Lung	NCIH1703	9
Lung	NCIH1734	8.4
Lung	NCIH1755	9.2
Lung	NCIH1781	9
Lung	NCIH1792	7.4
Lung	NCIH1793	8.6
Lung	NCIH1836	7.4
Lung	NCIH1838	8.6
Lung	NCIH1869	8.3
Lung	NCIH1876	7.3
Lung	NCIH1915	7.9
Lung	NCIH1930	9.2
Lung	NCIH1944	8.9
Lung	NCIH1963	7.8
Lung	NCIH196	8.9
Lung	NCIH1975	7.9
Lung	NCIH2009	7.5
Lung	NCIH2023	9.2
Lung	NCIH2029	8.3
Lung	NCIH2030	8.3
Lung	NCIH2066	8.9
Lung	NCIH2081	8.3
Lung	NCIH2085	7.3
Lung	NCIH2087	8
Lung	NCIH209	8.2
Lung	NCIH2106	8.3
Lung	NCIH2110	8.2
Lung	NCIH211	7.9
Lung	NCIH2122	9.3
Lung	NCIH2126	9
Lung	NCIH2141	8.6
Lung	NCIH2170	8.5
Lung	NCIH2171	9.1
Lung	NCIH2172	8.3
Lung	NCIH2196	8.9
Lung	NCIH2227	8.8
Lung	NCIH2228	8.2
Lung	NCIH226	8.7
Lung	NCIH2286	7.8
Lung	NCIH2291	8.6
Lung	NCIH2342	7.7
Lung	NCIH2347	8.3
Lung	NCIH23	9.1
Lung	NCIH2405	8.2
Lung	NCIH2444	8.3
Lung	NCIH292	8.1
Lung	NCIH322	8.4
Lung	NCIH3255	9
Lung	NCIH358	8.7
Lung	NCIH441	8.8
Lung	NCIH446	8.7
Lung	NCIH460	8.9
Lung	NCIH510	8.1
Lung	NCIH520	8
Lung	NCIH522	8.5
Lung	NCIH524	8
Lung	NCIH526	8.6
Lung	NCIH596	9.1
Lung	NCIH647	7
Lung	NCIH650	7.4
Lung	NCIH661	8.4
Lung	NCIH69	7.5
Lung	NCIH727	8.1
Lung	NCIH810	8.3
Lung	NCIH82	6.8
Lung	NCIH838	7.9
Lung	NCIH841	8.4
Lung	NCIH854	9.9
Lung	NCIH889	7.6
Lung	PC14	8.1
Lung	RERFLCAD1	7.6
Lung	RERFLCAD2	7.2
Lung	RERFLCAI	7.7
Lung	RERFLCKJ	9.6
Lung	RERFLCMS	8.3
Lung	RERFLCSQ1	8.4
Lung	SBC5	8.6
Lung	SCLC21H	7.8
Lung	SHP77	9.2
Lung	SKLU1	7.9
Lung	SKMES1	7.9
Lung	SQ1	8.1
Lung	SW1271	7.5
Lung	SW1573	7.3
Lung	SW900	8.2
Lung	VMRCLCD	8.7
Lung	VMRCLCP	8.9
Oesophagus	COLO680N	8.5
Oesophagus	ECGI10	10.3
Oesophagus	KYSE140	8.5
Oesophagus	KYSE150	8.8
Oesophagus	KYSE180	9.2
Oesophagus	KYSE270	7.5
Oesophagus	KYSE30	9.4
Oesophagus	KYSE410	8.4
Oesophagus	KYSE450	9.5
Oesophagus	KYSE510	8.8
Oesophagus	KYSE520	7.7
Oesophagus	KYSE70	9.3
Oesophagus	OE19	9.7
Oesophagus	OE33	6.9
Oesophagus	TE10	9
Oesophagus	TE11	8.7
Oesophagus	TE14	9.9
Oesophagus	TE15	9.1
Oesophagus	TE1	8
Oesophagus	TE4	9
Oesophagus	TE5	9
Oesophagus	TE6	8.6
Oesophagus	TE8	8.4
Oesophagus	TE9	8.8
Oesophagus	TT	8.9
Ovary	59M	7.9
Ovary	A2780	9.3
Ovary	CAOV3	7.6
Ovary	CAOV4	7.8
Ovary	COLO704	8.7
Ovary	COV318	8.1
Ovary	COV362	7.8
Ovary	COV434	9.2
Ovary	COV504	7.9
Ovary	COV644	8.4
Ovary	EFO21	9.8
Ovary	EFO27	7.7
Ovary	ES2	7.5
Ovary	FUOV1	7.1
Ovary	HEYA8	6.8
Ovary	HS571T	7.6
Ovary	IGROV1	8.1
Ovary	JHOC5	7.3
Ovary	JHOM1	8.8
Ovary	JHOM2B	8
Ovary	JHOS2	8.3
Ovary	JHOS4	8.7
Ovary	KURAMOCHI	8.3
Ovary	MCAS	8.8
Ovary	NIHOVCAR3	8.1
Ovary	OAW28	7.6
Ovary	OAW42	8.7
Ovary	OC314	7.7
Ovary	OC316	7.1
Ovary	ONCODG1	8.5
Ovary	OV56	7.8
Ovary	OV7	8
Ovary	OV90	9.3
Ovary	OVCAR4	9.3
Ovary	OVCAR8	8
Ovary	OVISE	7.3
Ovary	OVK18	9.3
Ovary	OVKATE	8.7
Ovary	OVMANA	7.1
Ovary	OVSAHO	8.4
Ovary	OVTOKO	7.6
Ovary	RMGI	8.6
Ovary	RMUGS	8.8
Ovary	SKOV3	7.1
Ovary	SNU119	7.6
Ovary	SNU840	8.7
Ovary	SNU8	7.7
Ovary	TOV112D	7.9
Ovary	TOV21G	7.2
Ovary	TYKNU	7.6
Pancreas	ASPC1	8
Pancreas	BXPC3	8.2
Pancreas	CAPAN1	8.5
Pancreas	CAPAN2	8.1
Pancreas	CFPAC1	7.9
Pancreas	DANG	7.1
Pancreas	HPAC	8.1
Pancreas	HPAFII	7.1
Pancreas	HS766T	7.2
Pancreas	HUPT3	7.7
Pancreas	HUPT4	8.1
Pancreas	KCIMOH1	8.1
Pancreas	KLM1	9.9
Pancreas	KP2	8.9
Pancreas	KP3	8.7
Pancreas	KP4	8.4
Pancreas	L33	9
Pancreas	MIAPACA2	8.5
Pancreas	PANC0203	8.6
Pancreas	PANC0213	8.2
Pancreas	PANC0327	7.7
Pancreas	PANC0403	7.8
Pancreas	PANC0504	8.6
Pancreas	PANC0813	8.9
Pancreas	PANC1005	7.7
Pancreas	PANC1	8.3
Pancreas	PATU8902	7.7
Pancreas	PATU8988S	7.8
Pancreas	PATU8988T	7.2
Pancreas	PK1	8.6
Pancreas	PK45H	8
Pancreas	PK59	9.1
Pancreas	PL45	7.8
Pancreas	PSN1	8.3
Pancreas	QGP1	10.5
Pancreas	SNU213	8
Pancreas	SNU324	8.6
Pancreas	SNU410	8.8
Pancreas	SU8686	9.7
Pancreas	SUIT2	7.7
Pancreas	SW1990	8.5
Pancreas	T3M4	9.3
Pancreas	TCCPAN2	9
Pancreas	YAPC	8.2
Pleura	ACCMESO1	7.2
Pleura	DM3	7.7
Pleura	ISTMES1	8
Pleura	ISTMES2	9.4
Pleura	JL1	8.9
Pleura	MPP89	8
Pleura	MSTO211H	7.6
Pleura	NCIH2052	7.9
Pleura	NCIH2452	8.2
Pleura	NCIH28	7.9
Prostate	22RV1	9.1
Prostate	DU145	7.3
Prostate	LNCAPCLONEFGC	9.9
Prostate	MDAPCA2B	8.4
Prostate	NCIH660	9.4
Prostate	PC3	7.7
Prostate	VCAP	7.8
Salivary gland	A253	7.8
Salivary gland	YD15	8.3
Skin	A101D	8.7
Skin	A2058	9.8
Skin	A375	8.7
Skin	C32	9.6
Skin	CHL1	9.2
Skin	CJM	10.3
Skin	COLO679	9.5
Skin	COLO741	9.1
Skin	COLO783	9
Skin	COLO792	8.6
Skin	COLO800	9.2
Skin	COLO818	8.9
Skin	COLO829	9.4
Skin	COLO849	9.6
Skin	G361	9.1
Skin	GRM	8.7
Skin	HMCB	9.2
Skin	HS294T	8.5
Skin	HS600T	7.4
Skin	HS688AT	7.6
Skin	HS695T	9.1
Skin	HS839T	7.3
Skin	HS852T	8.4
Skin	HS895T	6.6
Skin	HS934T	6.9
Skin	HS936T	9.8
Skin	HS939T	9.7
Skin	HS940T	7.8
Skin	HS944T	8.9
Skin	HT144	9.1
Skin	IGR1	8
Skin	IGR37	9.8
Skin	IGR39	8.6
Skin	IPC298	8.9
Skin	K029AX	9.1
Skin	LOXIMVI	8.6
Skin	MALME3M	9.4
Skin	MDAMB435S	8.5
Skin	MELHO	9.1
Skin	MELJUSO	9.7
Skin	MEWO	9.1
Skin	RPMI7951	7.9
Skin	RVH421	9
Skin	SH4	9.9
Skin	SKMEL1	8.9
Skin	SKMEL24	8.5
Skin	SKMEL28	9.2
Skin	SKMEL2	9.2
Skin	SKMEL30	9.6
Skin	SKMEL31	9.5
Skin	SKMEL3	9.8
Skin	SKMEL5	10.3
Skin	UACC257	9.4
Skin	UACC62	9.1
Skin	WM115	8.8
Skin	WM1799	9.1
Skin	WM2664	9.3
Skin	WM793	8.3
Skin	WM88	8.2
Skin	WM983B	8.8
Small intestine	HUTU80	8.8
Soft tissue	A204	8.5
Soft tissue	G401	8
Soft tissue	G402	8.9
Soft tissue	GCT	8.1
Soft tissue	HS729	7.8
Soft tissue	HT1080	7.9
Soft tissue	KYM1	8.1
Soft tissue	MESSA	9.4
Soft tissue	RD	7.8
Soft tissue	RH30	8.1
Soft tissue	RH41	8.3
Soft tissue	RKN	7.8
Soft tissue	S117	7.5
Soft tissue	SJRH30	7.8
Soft tissue	SKLMS1	7.6
Soft tissue	SKUT1	7.5
Soft tissue	TE125T	7.5
Soft tissue	TE159T	7.3
Soft tissue	TE441T	8.2
Soft tissue	TE617T	9
Stomach	2313287	10
Stomach	AGS	9.2
Stomach	AZ521	8.5
Stomach	ECC10	9.8
Stomach	ECC12	8
Stomach	FU97	8.9
Stomach	GCIY	7
Stomach	GSS	10.4
Stomach	GSU	9.1
Stomach	HGC27	8.7
Stomach	HS746T	8.6
Stomach	HUG1N	8.9
Stomach	IM95	9
Stomach	KATOIII	9.7
Stomach	KE39	8.5
Stomach	LMSU	7.8
Stomach	MKN1	8.1
Stomach	MKN45	8.2
Stomach	MKN74	9.3
Stomach	MKN7	7
Stomach	NCCSTCK140	9.8
Stomach	NCIN87	8.2
Stomach	NUGC2	9
Stomach	NUGC3	6.5
Stomach	NUGC4	10.4
Stomach	OCUM1	8.8
Stomach	RERFGC1B	8.9
Stomach	SH10TC	8.2
Stomach	SNU16	8.3
Stomach	SNU1	9.5
Stomach	SNU216	8.3
Stomach	SNU520	8.9
Stomach	SNU5	7.6
Stomach	SNU601	9.4
Stomach	SNU620	8.9
Stomach	SNU668	9
Stomach	SNU719	10.6
Stomach	TGBC11TKB	9.6
Thyroid	8305C	7
Thyroid	8505C	7.1
Thyroid	BCPAP	8
Thyroid	BHT101	7.9
Thyroid	CAL62	7.1
Thyroid	CGTHW1	7.9
Thyroid	FTC133	8.1
Thyroid	FTC238	6.8
Thyroid	ML1	8.8
Thyroid	SW579	7.9
Thyroid	TT2609C02	8.3
Thyroid	TT	9.1
Upper aerodigestive tract	BHY	7.8
Upper aerodigestive tract	BICR16	8.3
Upper aerodigestive tract	BICR18	8.5
Upper aerodigestive tract	BICR22	9.2
Upper aerodigestive tract	BICR31	8.2
Upper aerodigestive tract	BICR56	9.3
Upper aerodigestive tract	BICR6	8
Upper aerodigestive tract	CAL27	7.9
Upper aerodigestive tract	CAL33	8.9
Upper aerodigestive tract	DETROIT562	7.3
Upper aerodigestive tract	FADU	8.4
Upper aerodigestive tract	HS840T	7.6
Upper aerodigestive tract	HSC2	8.2
Upper aerodigestive tract	HSC3	7.2
Upper aerodigestive tract	HSC4	8.3
Upper aerodigestive tract	PECAPJ15	7.8
Upper aerodigestive tract	PECAPJ34CLONEC12	8.5
Upper aerodigestive tract	PECAPJ41CLONED2	7
Upper aerodigestive tract	PECAPJ49	7.9
Upper aerodigestive tract	SCC15	7.6
Upper aerodigestive tract	SCC25	8
Upper aerodigestive tract	SCC4	7.8
Upper aerodigestive tract	SCC9	8.4
Upper aerodigestive tract	SNU1076	8.4
Upper aerodigestive tract	SNU1214	8.5
Upper aerodigestive tract	SNU46	7.6
Upper aerodigestive tract	SNU899	8.2
Upper aerodigestive tract	YD10B	8.3
Upper aerodigestive tract	YD38	7.8
Upper aerodigestive tract	YD8	7.8
Urinary tract	5637	8
Urinary tract	639V	7.8
Urinary tract	647V	7.4
Urinary tract	BC3C	8.1
Urinary tract	BFTC905	8.1
Urinary tract	CAL29	8.8
Urinary tract	HS172T	7.4
Urinary tract	HT1197	7.3
Urinary tract	HT1376	7.5
Urinary tract	J82	7.1
Urinary tract	JMSU1	7.6
Urinary tract	KMBC2	9
Urinary tract	KU1919	7.4
Urinary tract	RT11284	8.1
Urinary tract	RT112	8.4
Urinary tract	RT4	7.7
Urinary tract	SCABER	8.1
Urinary tract	SW1710	7
Urinary tract	SW780	8.5
Urinary tract	T24	7.9
Urinary tract	TCCSUP	9.6
Urinary tract	UMUC1	8.8
Urinary tract	UMUC3	7.6
Urinary tract	VMCUB1	8.6

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	6.7
Adrenal gland	9.5
Appendix	15.3
Bone marrow	85.3
Breast	6.9
Cerebral cortex	25.7
Cervix, uterine	5.3
Colon	4.9
Duodenum	7.4
Endometrium	7.2
Epididymis	5.6
Esophagus	9.2
Fallopian tube	6.9
Gallbladder	9.9
Heart muscle	5
Kidney	5.3
Liver	3.9
Lung	11.6
Lymph node	17
Ovary	9.5
Pancreas	3.4
Parathyroid gland	23.6
Placenta	22
Prostate	10.6
Rectum	3.6
Salivary gland	5.5
Seminal vesicle	6.5
Skeletal muscle	0.8
Skin	11.2
Small intestine	7.3
Smooth muscle	5.3
Spleen	22.5
Stomach	9.5
Testis	7.8
Thyroid gland	11.5
Tonsil	7
Urinary bladder	9.1

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26918056	overexpression	Osteosarcoma	The expression of CBX4 was up-regulated in multiple OS cell lines and clinical samples.
25766328	overexpression	Hepatocellular Carcinoma	Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angiogenesis and metastasis of hepatocellular carcinoma (HCC) through its sumoylating action on hypoxia-inducible factor-1α protein.
24916276	overexpression	Hepatocellular Carcinoma	Recently, we reported that polycomb chromobox 4 (Cbx4) governs the transcriptional activity of HIF-1α by enhancing its sumoylation at K391 and K477, through which Cbx4 potentiates angiogenesis of hepatocellular carcinoma.
24434214	aberrant expression	Hepatocellular Carcinoma	The Cbx4 expression is significantly correlated with VEGF expression, angiogenesis, and the overall survival of HCC patients and also in subcutaneously and orthotopically transplanted mice HCC models.
23943028	overexpression	Hepatocellular Carcinoma	The expression of CBX4 was up-regulated in multiple HCC cell lines and clinical samples.
23502315	overexpression	Leukemia	Cbx7 is specifically expressed in haematopoietic stem cells (HSCs), and its overexpression enhances self-renewal and induces leukaemia.

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.22	7.72e-06	4.7	47.8	47.5	Gain
BRCA	Breast invasive carcinoma	1075	0.313	7.17e-26	14.8	47.5	37.7	Gain
CESC	Cervical and endocervical cancers	292	0.252	1.34e-05	14.4	63	22.6	Neutral
COAD	Colon adenocarcinoma	449	0.215	4.2e-06	12	64.1	23.8	Neutral
ESCA	Esophageal carcinoma	183	0.212	0.00388	17.5	49.7	32.8	Neutral
GBM	Glioblastoma multiforme	147	0.153	0.0645	12.2	74.8	12.9	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.32	1.09e-13	10.1	68.9	21	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.126	0.00374	5.1	86.7	8.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.093	0.115	0.3	30.2	69.4	Gain
LAML	Acute Myeloid Leukemia	166	0.074	0.347	3	94.6	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.204	3.11e-06	2.3	88.7	9	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.265	3.05e-07	6.3	55.8	37.9	Gain
LUAD	Lung adenocarcinoma	512	0.282	8.52e-11	5.5	42.8	51.8	Gain
LUSC	Lung squamous cell carcinoma	498	0.346	1.89e-15	14.9	40.8	44.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.289	3.57e-07	32.3	29.3	38.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.226	0.00253	20.3	67.2	12.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.17	0.0303	8	85.2	6.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.137	0.00242	5.9	90.4	3.7	Neutral
READ	Rectum adenocarcinoma	164	0.166	0.0336	14.6	64.6	20.7	Neutral
SARC	Sarcoma	255	0.197	0.00161	19.6	52.9	27.5	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.346	9.7e-12	12	54.2	33.8	Gain
STAD	Stomach adenocarcinoma	413	0.254	1.64e-07	17.7	62.5	19.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	-0.083	0.312	6.7	54.7	38.7	Gain
THCA	Thyroid carcinoma	497	0.07	0.12	0.2	95.6	4.2	Neutral
THYM	Thymoma	119	-0.04	0.668	3.4	88.2	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.217	3.75e-07	9.7	72.6	17.7	Neutral

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.113	0.0196	17	408	-0.051	0.257	NS/NA
BRCA	Breast invasive carcinoma	-0.112	0.000915	83	785	-0.002	0.0626	NS/NA
CESC	Cervical and endocervical cancers	-0.161	0.00464	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.129	0.0221	19	297	-0.044	0.674	NS/NA
ESCA	Esophageal carcinoma	-0.097	0.179	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.128	0.307	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.129	0.00264	20	522	0.002	9.5e-05	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.13	0.0158	24	319	0.101	7.56e-11	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.074	0.204	23	275	0.002	0.0858	NS/NA
LAML	Acute Myeloid Leukemia	-0.103	0.181	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.065	0.138	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.269	3.08e-08	41	373	-0.103	6.68e-13	NS/NA
LUAD	Lung adenocarcinoma	-0.064	0.165	21	456	-0.005	0.0856	NS/NA
LUSC	Lung squamous cell carcinoma	-0.131	0.0108	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.567	0.121	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.18	0.0151	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.139	0.0578	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.038	0.381	35	498	-0.005	0.0392	NS/NA
READ	Rectum adenocarcinoma	-0.202	0.0426	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.148	0.0162	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.241	1.27e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.018	0.722	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.496	5.07e-11	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.233	2.77e-08	50	509	-0.003	0.35	NS/NA
THYM	Thymoma	-0.072	0.428	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.077	0.0985	34	431	-0.095	8.04e-08	NS/NA

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	2	Medium
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	3	High
Endometrium	3	High
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	3	High
Heart muscle	1	Low
Hippocampus	2	Medium
Kidney	3	High
Liver	1	Low
Lung	3	High
Lymph node	1	Low
Oral mucosa	2	Medium
Ovary	1	Low
Pancreas	2	Medium
Placenta	3	High
Prostate	1	Low
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	0	Not detected
Skin	3	High
Small intestine	1	Low
Smooth muscle	2	Medium
Soft tissue	1	Low
Spleen	1	Low
Stomach	3	High
Testis	3	High
Thyroid gland	2	Medium
Tonsil	1	Low
Urinary bladder	2	Medium
Vagina	1	Low

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.681	NS	24476821
BRCA	Breast invasive carcinoma	521	2.24e-23	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0311	Significant	22810696
GBM	Glioblastoma multiforme	157	1.37e-07	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.000838	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.000179	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.66e-14	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0352	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00564	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.176	NS	21720365
PRAD	Prostate adenocarcinoma	333	1.85e-12	Significant	26544944
READ	Rectum adenocarcinoma	67	0.322	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.662	NS	26091043
STAD	Stomach adenocarcinoma	277	2.34e-06	Significant	25079317
THCA	Thyroid carcinoma	391	1.32e-12	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00783	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.117	0.592	NS
BRCA	Breast invasive carcinoma	1079	1.018	0.941	NS
CESC	Cervical and endocervical cancers	291	1.021	0.95	NS
COAD	Colon adenocarcinoma	439	1.3	0.388	NS
ESCA	Esophageal carcinoma	184	1.411	0.261	NS
GBM	Glioblastoma multiforme	158	0.716	0.206	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.098	0.634	NS
KIRC	Kidney renal clear cell carcinoma	531	3.219	1.51e-07	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	2.884	0.00553	Shorter
LAML	Acute Myeloid Leukemia	149	0.887	0.689	NS
LGG	Brain Lower Grade Glioma	511	0.735	0.216	NS
LIHC	Liver hepatocellular carcinoma	365	1.484	0.11	NS
LUAD	Lung adenocarcinoma	502	1.28	0.255	NS
LUSC	Lung squamous cell carcinoma	494	1.001	0.996	NS
OV	Ovarian serous cystadenocarcinoma	303	0.725	0.119	NS
PAAD	Pancreatic adenocarcinoma	177	0.628	0.111	NS
PCPG	Pheochromocytoma and Paraganglioma	179	4.326	0.181	NS
PRAD	Prostate adenocarcinoma	497	1.105	0.9	NS
READ	Rectum adenocarcinoma	159	2.589	0.139	NS
SARC	Sarcoma	259	0.859	0.577	NS
SKCM	Skin Cutaneous Melanoma	459	1.193	0.364	NS
STAD	Stomach adenocarcinoma	388	0.731	0.146	NS
TGCT	Testicular Germ Cell Tumors	134	723430395.911	0.273	NS
THCA	Thyroid carcinoma	500	0.837	0.816	NS
THYM	Thymoma	119	1.076	0.928	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.17	0.601	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.088	0.0758	NS
BRCA	Breast invasive carcinoma	1071	0.067	0.0285	Higher
CESC	Cervical and endocervical cancers	167	0.217	0.00484	Higher
COAD	Colon adenocarcinoma	445	0.091	0.0556	NS
ESCA	Esophageal carcinoma	162	0.02	0.799	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.053	0.263	NS
KIRC	Kidney renal clear cell carcinoma	531	0.221	2.74e-07	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.203	0.001	Higher
LIHC	Liver hepatocellular carcinoma	347	0.106	0.0482	Higher
LUAD	Lung adenocarcinoma	507	0.074	0.0966	NS
LUSC	Lung squamous cell carcinoma	497	0.016	0.724	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.18	0.00169	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.019	0.802	NS
READ	Rectum adenocarcinoma	156	0.001	0.987	NS
SKCM	Skin Cutaneous Melanoma	410	-0.017	0.735	NS
STAD	Stomach adenocarcinoma	392	-0.033	0.512	NS
TGCT	Testicular Germ Cell Tumors	81	-0.278	0.012	Lower
THCA	Thyroid carcinoma	499	-0.04	0.376	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.035	0.429	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.005	0.938	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.12	0.00723	Lower
KIRC	Kidney renal clear cell carcinoma	525	0.218	4.3e-07	Higher
LGG	Brain Lower Grade Glioma	514	-0.002	0.963	NS
LIHC	Liver hepatocellular carcinoma	366	0.057	0.273	NS
OV	Ovarian serous cystadenocarcinoma	296	0.012	0.84	NS
PAAD	Pancreatic adenocarcinoma	176	0.001	0.994	NS
STAD	Stomach adenocarcinoma	406	-0.126	0.011	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.113	0.00875	Higher

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for CBX4.

Summary
Symbol	CBX4
Name	chromobox 4
Aliases	NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog (Drosophila); chromobox homolog 4 (Drosophila Pc class ......
Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26918056	Osteosarcoma	downstream	HIF-1α-targeted genes	positive regulation	In addition, we found that knockdown of CBX4 lead to down-regulating of HIF-1α-targeted genes without changing HIF-1α expression itself.
25766328	Hepatocellular Carcinoma	downstream	HIF-1α	regulation	Our recent investigations showed that polycomb chromobox 4 (Cbx4) promotes angiogenesis and metastasis of hepatocellular carcinoma (HCC) through its sumoylating action on hypoxia-inducible factor-1α protein.
24916276	Hepatocellular Carcinoma	downstream	HIF-1α	regulation	Recently, we reported that polycomb chromobox 4 (Cbx4) governs the transcriptional activity of HIF-1α by enhancing its sumoylation at K391 and K477, through which Cbx4 potentiates angiogenesis of hepatocellular carcinoma.
24434214	Hepatocellular Carcinoma	downstream	VEGF; HIF-1α	positive regulation	Here, we report that Cbx4, but not other members of the Cbx family, enhances hypoxia-induced vascular endothelial growth factor (VEGF) expression and angiogenesis in hepatocellular carcinoma (HCC) cells through enhancing HIF-1α sumoylations at K391 and K477 in its two SUMO-interacting motifs-dependent mechanisms and increasing transcriptional activity of HIF-1.
23943028	Hepatocellular Carcinoma	partner	AFP	correlation	Although the CBX4 protein was detectable in both nucleus and cytoplasm in HCC tumor tissues, the high expression of CBX4 in cytoplasm was correlated with the α-fetoprotein level in serum (P = 0.036), tumor size (P = 0.029), pathologic differentiation (P = 0.033), and tumor, node, metastasis classification system stages (P = 0.032).