CR2Cancer

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF08074 CHDCT2 (NUC038) domain
PF08073 CHDNT (NUC034) domain
PF00385 Chromo (CHRromatin Organisation MOdifier) domain
PF06461 Domain of Unknown Function (DUF1086)
PF06465 Domain of Unknown Function (DUF1087)
PF00271 Helicase conserved C-terminal domain
PF00628 PHD-finger
PF00176 SNF2 family N-terminal domain

Function

Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	#	#	12592387

> Gene Ontology [ TOP ]
Biological Process	GO:0000226 microtubule cytoskeleton organization GO:0006338 chromatin remodeling GO:0006476 protein deacetylation GO:0007051 spindle organization GO:0016570 histone modification GO:0016575 histone deacetylation GO:0032392 DNA geometric change GO:0032508 DNA duplex unwinding GO:0035601 protein deacylation GO:0043044 ATP-dependent chromatin remodeling GO:0050808 synapse organization GO:0051225 spindle assembly GO:0071103 DNA conformation change GO:0072331 signal transduction by p53 class mediator GO:0072553 terminal button organization GO:0098732 macromolecule deacylation GO:1901796 regulation of signal transduction by p53 class mediator
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001085 RNA polymerase II transcription factor binding GO:0001103 RNA polymerase II repressing transcription factor binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003678 DNA helicase activity GO:0003682 chromatin binding GO:0004003 ATP-dependent DNA helicase activity GO:0004386 helicase activity GO:0004407 histone deacetylase activity GO:0008017 microtubule binding GO:0008026 ATP-dependent helicase activity GO:0008094 DNA-dependent ATPase activity GO:0008134 transcription factor binding GO:0015631 tubulin binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016887 ATPase activity GO:0019213 deacetylase activity GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0033558 protein deacetylase activity GO:0035326 enhancer binding GO:0042623 ATPase activity, coupled GO:0043566 structure-specific DNA binding GO:0070035 purine NTP-dependent helicase activity GO:0070491 repressing transcription factor binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005813 centrosome GO:0016581 NuRD complex GO:0017053 transcriptional repressor complex GO:0032993 protein-DNA complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0090545 CHD-type complex GO:0090568 nuclear transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214815: HDACs deacetylate histones R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73864: RNA Polymerase I Transcription R-HSA-73762: RNA Polymerase I Transcription Initiation R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804758: Regulation of TP53 Activity through Acetylation R-HSA-3700989: Transcriptional Regulation by TP53

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214815: HDACs deacetylate histones
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804758: Regulation of TP53 Activity through Acetylation
R-HSA-3700989: Transcriptional Regulation by TP53

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1299792	c.4111G>C	p.E1371Q	Substitution - Missense	Urinary_tract
COSM4136211	c.293A>T	p.E98V	Substitution - Missense	Pancreas
COSM5781836	c.3879+2T>A	p.?	Unknown	Breast
COSM4891544	c.249G>A	p.G83G	Substitution - coding silent	Upper_aerodigestive_tract
COSM1704967	c.4091C>T	p.S1364F	Substitution - Missense	Skin
COSM1639220	c.3380G>A	p.R1127Q	Substitution - Missense	Prostate
COSM1128492	c.5361+1G>A	p.?	Unknown	Prostate
COSM4966847	c.2744T>G	p.L915R	Substitution - Missense	Prostate
COSM1363771	c.1039C>T	p.R347*	Substitution - Nonsense	Large_intestine
COSM4044346	c.2114C>T	p.T705I	Substitution - Missense	Stomach
COSM4749360	c.1840C>T	p.R614C	Substitution - Missense	Stomach
COSM4575677	c.1992C>T	p.Y664Y	Substitution - coding silent	Bone
COSM2098405	c.4047C>A	p.S1349S	Substitution - coding silent	Upper_aerodigestive_tract
COSM2098411	c.4002C>T	p.G1334G	Substitution - coding silent	Large_intestine
COSM1639217	c.5190T>C	p.H1730H	Substitution - coding silent	Stomach
COSM3987165	c.203G>C	p.S68T	Substitution - Missense	Kidney
COSM5725912	c.5460C>T	p.T1820T	Substitution - coding silent	Skin
COSM4044331	c.3314G>A	p.R1105Q	Substitution - Missense	Stomach
COSM1476829	c.4812T>C	p.D1604D	Substitution - coding silent	Breast
COSM1476847	c.355_357delAAG	p.K119delK	Deletion - In frame	Breast
COSM1363771	c.1039C>T	p.R347*	Substitution - Nonsense	Skin
COSM3812807	c.5604G>A	p.V1868V	Substitution - coding silent	Breast
COSM3955074	c.1911C>A	p.H637Q	Substitution - Missense	Lung
COSM1586694	c.3644T>G	p.L1215R	Substitution - Missense	Endometrium
COSM3464389	c.2322C>T	p.S774S	Substitution - coding silent	Skin
COSM3356346	c.3733A>C	p.S1245R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1645718	c.4669G>A	p.V1557I	Substitution - Missense	Kidney
COSM4147408	c.1006A>C	p.T336P	Substitution - Missense	Upper_aerodigestive_tract
COSM5556232	c.3063T>C	p.H1021H	Substitution - coding silent	Prostate
COSM4749355	c.5234G>T	p.G1745V	Substitution - Missense	Stomach
COSM4671995	c.3992G>A	p.R1331Q	Substitution - Missense	Large_intestine
COSM3384572	c.2881G>A	p.D961N	Substitution - Missense	Pancreas
COSM1363779	c.218delA	p.K73fs*129	Deletion - Frameshift	Stomach
COSM2098718	c.56A>G	p.D19G	Substitution - Missense	Large_intestine
COSM1606531	c.2288T>G	p.V763G	Substitution - Missense	Liver
COSM1606521	c.5084G>A	p.R1695H	Substitution - Missense	Liver
COSM4986789	c.4657A>C	p.T1553P	Substitution - Missense	Soft_tissue
COSM2098705	c.182G>A	p.R61Q	Substitution - Missense	Endometrium
COSM1586701	c.5441C>A	p.P1814H	Substitution - Missense	Endometrium
COSM3812826	c.3967G>C	p.E1323Q	Substitution - Missense	Breast
COSM1704961	c.4622C>T	p.P1541L	Substitution - Missense	Skin
COSM5554774	c.5031A>G	p.G1677G	Substitution - coding silent	Prostate
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM1586692	c.3475A>G	p.R1159G	Substitution - Missense	Endometrium
COSM4870928	c.2869C>T	p.R957W	Substitution - Missense	Endometrium
COSM39949	c.4601G>A	p.G1534E	Substitution - Missense	Central_nervous_system
COSM2098545	c.2343C>T	p.S781S	Substitution - coding silent	Prostate
COSM5029893	c.1401T>C	p.C467C	Substitution - coding silent	Bone
COSM1586685	c.915T>C	p.R305R	Substitution - coding silent	Endometrium
COSM3781053	c.3331C>T	p.R1111C	Substitution - Missense	Pancreas
COSM1606521	c.5084G>A	p.R1695H	Substitution - Missense	Liver
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Prostate
COSM1363779	c.218delA	p.K73fs*129	Deletion - Frameshift	Biliary_tract
COSM1704961	c.4622C>T	p.P1541L	Substitution - Missense	Skin
COSM1742424	c.1618G>C	p.E540Q	Substitution - Missense	Urinary_tract
COSM3936108	c.5003A>G	p.E1668G	Substitution - Missense	Oesophagus
COSM5925662	c.4780-8C>T	p.?	Unknown	Skin
COSM1704970	c.2170G>T	p.G724*	Substitution - Nonsense	Skin
COSM3676523	c.13C>T	p.L5L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1756803	c.3305G>A	p.G1102E	Substitution - Missense	Urinary_tract
COSM1317975	c.2924G>A	p.R975H	Substitution - Missense	Endometrium
COSM1586699	c.4866G>T	p.E1622D	Substitution - Missense	Endometrium
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM1363779	c.218delA	p.K73fs*129	Deletion - Frameshift	Large_intestine
COSM1317975	c.2924G>A	p.R975H	Substitution - Missense	Endometrium
COSM1476840	c.1863G>A	p.W621*	Substitution - Nonsense	Breast
COSM1586688	c.2212C>T	p.R738C	Substitution - Missense	Endometrium
COSM1582157	c.4698A>G	p.I1566M	Substitution - Missense	Stomach
COSM1704976	c.772C>T	p.R258C	Substitution - Missense	Skin
COSM4874266	c.2907G>C	p.K969N	Substitution - Missense	Endometrium
COSM5361414	c.1857C>T	p.P619P	Substitution - coding silent	Large_intestine
COSM2098405	c.4047C>A	p.S1349S	Substitution - coding silent	Upper_aerodigestive_tract
COSM2098405	c.4047C>A	p.S1349S	Substitution - coding silent	Upper_aerodigestive_tract
COSM39948	c.1935G>A	p.R645R	Substitution - coding silent	Central_nervous_system
COSM2098262	c.5398C>T	p.R1800C	Substitution - Missense	Stomach
COSM3792911	c.3223-1G>A	p.?	Unknown	Urinary_tract
COSM2098397	c.4107T>C	p.A1369A	Substitution - coding silent	Upper_aerodigestive_tract
COSM1299789	c.4405G>C	p.E1469Q	Substitution - Missense	Urinary_tract
COSM1578825	c.2867G>A	p.R956Q	Substitution - Missense	Meninges
COSM1756797	c.5437C>T	p.H1813Y	Substitution - Missense	Urinary_tract
COSM1323106	c.846T>C	p.D282D	Substitution - coding silent	Ovary
COSM3720386	c.4001G>A	p.G1334D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM5349459	c.2768G>A	p.R923K	Substitution - Missense	Liver
COSM5734168	c.2374C>T	p.R792W	Substitution - Missense	Pancreas
COSM3729048	c.4780-10delT	p.?	Unknown	Stomach
COSM3417080	c.206A>C	p.K69T	Substitution - Missense	Large_intestine
COSM5352041	c.3656T>A	p.L1219H	Substitution - Missense	Kidney
COSM3812815	c.4665A>C	p.A1555A	Substitution - coding silent	Breast
COSM3464386	c.2481C>T	p.A827A	Substitution - coding silent	Skin
COSM5375816	c.3261A>G	p.E1087E	Substitution - coding silent	Skin
COSM5725917	c.3801C>T	p.D1267D	Substitution - coding silent	Skin
COSM2098605	c.1542A>G	p.P514P	Substitution - coding silent	Liver
COSM4044294	c.4946C>T	p.A1649V	Substitution - Missense	Stomach
COSM1646551	c.4615A>G	p.K1539E	Substitution - Missense	Lung
COSM1317975	c.2924G>A	p.R975H	Substitution - Missense	Endometrium
COSM1586698	c.4467C>A	p.R1489R	Substitution - coding silent	Endometrium
COSM1756803	c.3305G>A	p.G1102E	Substitution - Missense	Urinary_tract
COSM2098397	c.4107T>C	p.A1369A	Substitution - coding silent	Upper_aerodigestive_tract
COSM4641766	c.1792C>T	p.R598*	Substitution - Nonsense	Large_intestine
COSM3812823	c.4224T>G	p.G1408G	Substitution - coding silent	Breast
COSM5552860	c.4428G>C	p.E1476D	Substitution - Missense	Prostate
COSM3710972	c.2395C>G	p.P799A	Substitution - Missense	Upper_aerodigestive_tract
COSM4672029	c.863C>A	p.P288H	Substitution - Missense	Large_intestine
COSM4874494	c.3743A>C	p.H1248P	Substitution - Missense	Endometrium
COSM5039081	c.1646G>T	p.G549V	Substitution - Missense	Liver
COSM4044305	c.4288C>T	p.R1430*	Substitution - Nonsense	Stomach
COSM1476836	c.2710C>A	p.P904T	Substitution - Missense	Endometrium
COSM5035308	c.931G>T	p.E311*	Substitution - Nonsense	Oesophagus
COSM4147408	c.1006A>C	p.T336P	Substitution - Missense	Thyroid
COSM1628792	c.3696T>A	p.T1232T	Substitution - coding silent	Liver
COSM2098605	c.1542A>G	p.P514P	Substitution - coding silent	Liver
COSM2098512	c.2870G>A	p.R957Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5479300	c.604A>G	p.M202V	Substitution - Missense	Large_intestine
COSM1476853	c.100+1G>A	p.?	Unknown	Breast
COSM5789075	c.3840C>G	p.F1280L	Substitution - Missense	Breast
COSM5015072	c.845A>G	p.D282G	Substitution - Missense	Kidney
COSM1317975	c.2924G>A	p.R975H	Substitution - Missense	Ovary
COSM1317975	c.2924G>A	p.R975H	Substitution - Missense	Pancreas
COSM4672019	c.1622G>A	p.R541Q	Substitution - Missense	Small_intestine
COSM4865651	c.3407C>A	p.A1136D	Substitution - Missense	Endometrium
COSM1476831	c.3484C>T	p.R1162W	Substitution - Missense	Breast
COSM4770446	c.763G>A	p.V255M	Substitution - Missense	Adrenal_gland
COSM1606528	c.3709_3725del17	p.D1237fs*2	Deletion - Frameshift	Liver
COSM2098420	c.3909T>A	p.I1303I	Substitution - coding silent	Upper_aerodigestive_tract
COSM4863345	c.3389G>A	p.G1130D	Substitution - Missense	Endometrium
COSM4957033	c.1421A>G	p.H474R	Substitution - Missense	Liver
COSM1132974	c.340_358>16	p.K119delK	Deletion - In frame	Central_nervous_system
COSM4970312	c.1947C>T	p.Y649Y	Substitution - coding silent	Central_nervous_system
COSM4044358	c.1559C>A	p.P520H	Substitution - Missense	Stomach
COSM5913353	c.3529C>T	p.R1177C	Substitution - Missense	Skin
COSM3464405	c.1676C>T	p.S559F	Substitution - Missense	Skin
COSM5361414	c.1857C>T	p.P619P	Substitution - coding silent	Large_intestine
COSM1586700	c.5422T>C	p.S1808P	Substitution - Missense	Endometrium
COSM5362004	c.857C>T	p.P286L	Substitution - Missense	Large_intestine
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Large_intestine
COSM5792822	c.3338A>G	p.N1113S	Substitution - Missense	Breast
COSM1676671	c.2554T>C	p.Y852H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1299786	c.4621C>G	p.P1541A	Substitution - Missense	Urinary_tract
COSM5980245	c.3497A>G	p.N1166S	Substitution - Missense	Upper_aerodigestive_tract
COSM5015075	c.357G>C	p.K119N	Substitution - Missense	Kidney
COSM2098581	c.1687-9C>T	p.?	Unknown	Large_intestine
COSM4044352	c.1831C>T	p.R611C	Substitution - Missense	Stomach
COSM5783608	c.2257A>G	p.M753V	Substitution - Missense	Breast
COSM1363769	c.1412A>G	p.Y471C	Substitution - Missense	Large_intestine
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM5462261	c.4787A>G	p.Q1596R	Substitution - Missense	Large_intestine
COSM5730360	c.2812G>A	p.A938T	Substitution - Missense	Breast
COSM5924571	c.4450C>T	p.R1484*	Substitution - Nonsense	Skin
COSM5454158	c.4910-4C>A	p.?	Unknown	Large_intestine
COSM4765564	c.2836_2837insA	p.L946fs*3	Insertion - Frameshift	Stomach
COSM2098405	c.4047C>A	p.S1349S	Substitution - coding silent	Upper_aerodigestive_tract
COSM5733230	c.1156G>A	p.D386N	Substitution - Missense	Pancreas
COSM1756797	c.5437C>T	p.H1813Y	Substitution - Missense	Urinary_tract
COSM4639911	c.1293G>A	p.E431E	Substitution - coding silent	Large_intestine
COSM5613599	c.3581T>A	p.L1194Q	Substitution - Missense	Lung
COSM4044288	c.5195G>T	p.R1732L	Substitution - Missense	Stomach
COSM1476831	c.3484C>T	p.R1162W	Substitution - Missense	Endometrium
COSM1645719	c.4703A>C	p.E1568A	Substitution - Missense	Kidney
COSM3464417	c.92C>T	p.P31L	Substitution - Missense	Skin
COSM1248206	c.5402G>A	p.R1801Q	Substitution - Missense	Oesophagus
COSM2098385	c.4178G>A	p.R1393Q	Substitution - Missense	Large_intestine
COSM2098506	c.2924G>T	p.R975L	Substitution - Missense	Breast
COSM3812834	c.3560T>G	p.V1187G	Substitution - Missense	Breast
COSM3812837	c.3195T>G	p.G1065G	Substitution - coding silent	Breast
COSM4044311	c.4127A>G	p.D1376G	Substitution - Missense	Stomach
COSM4813979	c.946G>C	p.D316H	Substitution - Missense	Breast
COSM1639220	c.3380G>A	p.R1127Q	Substitution - Missense	Stomach
COSM1476837	c.2630G>A	p.R877Q	Substitution - Missense	Endometrium
COSM1645717	c.2911G>C	p.E971Q	Substitution - Missense	Kidney
COSM4044361	c.324C>T	p.S108S	Substitution - coding silent	Stomach
COSM4868173	c.2437C>T	p.R813C	Substitution - Missense	Endometrium
COSM5631435	c.3702A>T	p.G1234G	Substitution - coding silent	Oesophagus
COSM5790765	c.2694G>T	p.L898L	Substitution - coding silent	Breast
COSM3739846	c.3280G>A	p.E1094K	Substitution - Missense	Large_intestine
COSM1646548	c.3319G>C	p.E1107Q	Substitution - Missense	Lung
COSM3998921	c.4626A>C	p.T1542T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3781053	c.3331C>T	p.R1111C	Substitution - Missense	Large_intestine
COSM1363756	c.1971G>A	p.E657E	Substitution - coding silent	Large_intestine
COSM1704967	c.4091C>T	p.S1364F	Substitution - Missense	Skin
COSM5007664	c.2966T>C	p.I989T	Substitution - Missense	Large_intestine
COSM1476836	c.2710C>A	p.P904T	Substitution - Missense	Breast
COSM4489479	c.3481C>T	p.H1161Y	Substitution - Missense	Skin
COSM4746574	c.1483-3_1483-2delCA	p.?	Unknown	Stomach
COSM1476837	c.2630G>A	p.R877Q	Substitution - Missense	Breast
COSM3812849	c.800G>T	p.G267V	Substitution - Missense	Breast
COSM4404140	c.2644C>T	p.Q882*	Substitution - Nonsense	Skin
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM3464395	c.1984C>T	p.Q662*	Substitution - Nonsense	Skin
COSM4147405	c.1548C>T	p.P516P	Substitution - coding silent	Thyroid
COSM4672035	c.630G>A	p.R210R	Substitution - coding silent	Large_intestine
COSM4946986	c.2989C>T	p.L997F	Substitution - Missense	Ovary
COSM4147402	c.4018C>A	p.R1340S	Substitution - Missense	Thyroid
COSM4044323	c.3787G>A	p.D1263N	Substitution - Missense	Stomach
COSM1476837	c.2630G>A	p.R877Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5347387	c.1625_1627delAGT	p.Q542_F543>L	Complex - deletion inframe	Liver
COSM5447052	c.2514+2T>C	p.?	Unknown	Large_intestine
COSM4672004	c.2923C>T	p.R975C	Substitution - Missense	Large_intestine
COSM4672023	c.1315G>A	p.G439R	Substitution - Missense	Large_intestine
COSM5893638	c.4150C>T	p.P1384S	Substitution - Missense	Skin
COSM2098345	c.4600G>A	p.G1534R	Substitution - Missense	Large_intestine
COSM3987162	c.1534C>T	p.Q512*	Substitution - Nonsense	Kidney
COSM3464380	c.2552C>T	p.S851F	Substitution - Missense	Skin
COSM1476838	c.2629C>T	p.R877W	Substitution - Missense	Breast
COSM1586689	c.2618A>G	p.D873G	Substitution - Missense	Endometrium
COSM1476828	c.4933G>T	p.E1645*	Substitution - Nonsense	Breast
COSM1299807	c.1618G>A	p.E540K	Substitution - Missense	Urinary_tract
COSM1676668	c.3250G>A	p.D1084N	Substitution - Missense	Large_intestine
COSM3812810	c.5599G>A	p.D1867N	Substitution - Missense	Breast
COSM3671172	c.1857C>A	p.P619P	Substitution - coding silent	Prostate
COSM6014806	c.1064-9C>G	p.?	Unknown	Skin
COSM3792914	c.2309A>G	p.K770R	Substitution - Missense	Urinary_tract
COSM5802615	c.1512_1513insAGA	p.K504_I505insR	Insertion - In frame	Breast
COSM2098420	c.3909T>A	p.I1303I	Substitution - coding silent	Upper_aerodigestive_tract
COSM4044291	c.5194C>T	p.R1732W	Substitution - Missense	Stomach
COSM4044343	c.2209T>C	p.L737L	Substitution - coding silent	Stomach
COSM1606525	c.4375T>C	p.Y1459H	Substitution - Missense	Liver
COSM2098376	c.4300C>T	p.P1434S	Substitution - Missense	Central_nervous_system
COSM4210588	c.400G>A	p.E134K	Substitution - Missense	Large_intestine
COSM4775757	c.3338A>T	p.N1113I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1586680	c.325G>A	p.D109N	Substitution - Missense	Endometrium
COSM2098420	c.3909T>A	p.I1303I	Substitution - coding silent	Upper_aerodigestive_tract
COSM4147408	c.1006A>C	p.T336P	Substitution - Missense	Upper_aerodigestive_tract
COSM3998921	c.4626A>C	p.T1542T	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1586696	c.3803C>T	p.T1268I	Substitution - Missense	Endometrium
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM4044326	c.3777C>T	p.D1259D	Substitution - coding silent	Stomach
COSM1317977	c.3517C>T	p.R1173W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2098426	c.3886_3895del10	p.E1296fs*31	Deletion - Frameshift	Upper_aerodigestive_tract
COSM4044355	c.1706T>C	p.V569A	Substitution - Missense	Stomach
COSM5916187	c.4661C>T	p.P1554L	Substitution - Missense	Skin
COSM4672016	c.2004G>A	p.K668K	Substitution - coding silent	Large_intestine
COSM1756800	c.5435C>T	p.S1812F	Substitution - Missense	Urinary_tract
COSM4811662	c.4869G>C	p.V1623V	Substitution - coding silent	Urinary_tract
COSM4940251	c.3020C>T	p.S1007F	Substitution - Missense	Liver
COSM4971731	c.4148-11_4148-9delTCT	p.?	Unknown	Central_nervous_system
COSM5419918	c.3030T>C	p.N1010N	Substitution - coding silent	Pancreas
COSM4672010	c.2410G>A	p.V804I	Substitution - Missense	Large_intestine
COSM1586697	c.4013G>T	p.R1338I	Substitution - Missense	Stomach
COSM3792906	c.4160C>T	p.P1387L	Substitution - Missense	Urinary_tract
COSM4044297	c.4747G>T	p.V1583F	Substitution - Missense	Stomach
COSM5634686	c.3748G>A	p.D1250N	Substitution - Missense	Oesophagus
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM2098562	c.1917C>T	p.H639H	Substitution - coding silent	Skin
COSM4672032	c.811C>T	p.R271W	Substitution - Missense	Large_intestine
COSM1586697	c.4013G>T	p.R1338I	Substitution - Missense	Endometrium
COSM4845630	c.5025G>A	p.Q1675Q	Substitution - coding silent	Cervix
COSM4575674	c.4533T>C	p.H1511H	Substitution - coding silent	Bone
COSM5905282	c.3880-4C>T	p.?	Unknown	Skin
COSM4044320	c.4005A>C	p.K1335N	Substitution - Missense	Stomach
COSM1317975	c.2924G>A	p.R975H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4846723	c.1393G>A	p.D465N	Substitution - Missense	Cervix
COSM4044317	c.4018C>T	p.R1340C	Substitution - Missense	Stomach
COSM4566828	c.4833_4834CC>TT	p.P1612S	Substitution - Missense	Skin
COSM1735161	c.3955C>T	p.R1319W	Substitution - Missense	Pancreas
COSM3704371	c.1687-5C>G	p.?	Unknown	Liver
COSM4044349	c.1975G>A	p.V659M	Substitution - Missense	Stomach
COSM1363736	c.4409C>T	p.P1470L	Substitution - Missense	Large_intestine
COSM1606534	c.687G>T	p.A229A	Substitution - coding silent	Liver
COSM1606534	c.687G>T	p.A229A	Substitution - coding silent	Liver
COSM2098420	c.3909T>A	p.I1303I	Substitution - coding silent	Upper_aerodigestive_tract
COSM4891429	c.4975G>T	p.D1659Y	Substitution - Missense	Upper_aerodigestive_tract
COSM3464386	c.2481C>T	p.A827A	Substitution - coding silent	Skin
COSM2098491	c.3202C>T	p.R1068C	Substitution - Missense	Skin
COSM1476831	c.3484C>T	p.R1162W	Substitution - Missense	Large_intestine
COSM4812768	c.5630G>A	p.R1877Q	Substitution - Missense	Urinary_tract
COSM3671170	c.2273C>T	p.T758I	Substitution - Missense	Prostate
COSM1586687	c.2140C>T	p.R714*	Substitution - Nonsense	Endometrium
COSM1736983	c.1031A>G	p.K344R	Substitution - Missense	Central_nervous_system
COSM2098394	c.4139G>A	p.R1380H	Substitution - Missense	Large_intestine
COSM3464374	c.3132C>T	p.A1044A	Substitution - coding silent	Skin
COSM4671989	c.5334G>T	p.K1778N	Substitution - Missense	Large_intestine
COSM3464371	c.3288C>T	p.I1096I	Substitution - coding silent	Skin
COSM4396436	c.4593C>T	p.S1531S	Substitution - coding silent	Skin
COSM5095167	c.2713T>G	p.L905V	Substitution - Missense	Thymus
COSM3384572	c.2881G>A	p.D961N	Substitution - Missense	Stomach
COSM5739561	c.2405A>G	p.Y802C	Substitution - Missense	Small_intestine
COSM4044334	c.3126C>T	p.G1042G	Substitution - coding silent	Stomach
COSM5631718	c.5179G>A	p.E1727K	Substitution - Missense	Oesophagus
COSM2098515	c.2835_2836insA	p.L946fs*3	Insertion - Frameshift	Large_intestine
COSM1586681	c.423T>G	p.D141E	Substitution - Missense	Endometrium
COSM4782323	c.1168C>T	p.R390C	Substitution - Missense	Stomach
COSM2098420	c.3909T>A	p.I1303I	Substitution - coding silent	Upper_aerodigestive_tract
COSM5916190	c.4660C>T	p.P1554S	Substitution - Missense	Skin
COSM3464414	c.494A>T	p.H165L	Substitution - Missense	Skin
COSM1704979	c.517C>T	p.R173*	Substitution - Nonsense	Skin
COSM4044340	c.2438G>A	p.R813H	Substitution - Missense	Stomach
COSM3464352	c.4479T>C	p.L1493L	Substitution - coding silent	Skin
COSM2098405	c.4047C>A	p.S1349S	Substitution - coding silent	Upper_aerodigestive_tract
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Skin
COSM3464377	c.2879C>T	p.A960V	Substitution - Missense	Skin
COSM1363766	c.1429A>G	p.N477D	Substitution - Missense	Large_intestine
COSM3464392	c.2165C>T	p.T722I	Substitution - Missense	Skin
COSM4672013	c.2359A>G	p.I787V	Substitution - Missense	Large_intestine
COSM1645720	c.4952A>C	p.D1651A	Substitution - Missense	Kidney
COSM1363739	c.4393C>T	p.R1465W	Substitution - Missense	Large_intestine
COSM3671167	c.3148G>T	p.G1050W	Substitution - Missense	Prostate
COSM5758406	c.2884G>T	p.V962L	Substitution - Missense	Bone
COSM3464337	c.5447T>C	p.M1816T	Substitution - Missense	Skin
COSM3968403	c.2366A>G	p.N789S	Substitution - Missense	Central_nervous_system
COSM5459758	c.2219C>G	p.S740C	Substitution - Missense	Large_intestine
COSM2098674	c.564C>A	p.L188L	Substitution - coding silent	Urinary_tract
COSM1317975	c.2924G>A	p.R975H	Substitution - Missense	Endometrium
COSM3359899	c.4217G>A	p.R1406H	Substitution - Missense	Kidney
COSM1363779	c.218delA	p.K73fs*129	Deletion - Frameshift	Prostate
COSM3464358	c.4148-7C>T	p.?	Unknown	Skin
COSM4856817	c.1948G>A	p.D650N	Substitution - Missense	Cervix
COSM1646549	c.3659A>G	p.K1220R	Substitution - Missense	Lung
COSM2098405	c.4047C>A	p.S1349S	Substitution - coding silent	Upper_aerodigestive_tract
COSM2098405	c.4047C>A	p.S1349S	Substitution - coding silent	Upper_aerodigestive_tract
COSM3812820	c.4528G>C	p.E1510Q	Substitution - Missense	Breast
COSM1128489	c.3778C>T	p.R1260C	Substitution - Missense	Prostate
COSM5202849	c.4007G>A	p.G1336E	Substitution - Missense	Breast
COSM2098599	c.1579C>T	p.P527S	Substitution - Missense	Skin
COSM3676523	c.13C>T	p.L5L	Substitution - coding silent	Oesophagus
COSM1476838	c.2629C>T	p.R877W	Substitution - Missense	Breast
COSM4835417	c.145C>G	p.P49A	Substitution - Missense	Cervix
COSM4848441	c.1797G>C	p.K599N	Substitution - Missense	Cervix
COSM5375819	c.1432_1433CC>TT	p.P478F	Substitution - Missense	Skin
COSM1363773	c.699G>A	p.A233A	Substitution - coding silent	Large_intestine
COSM5603173	c.2762C>T	p.P921L	Substitution - Missense	Skin
COSM4672007	c.2507G>A	p.R836H	Substitution - Missense	Large_intestine
COSM1476831	c.3484C>T	p.R1162W	Substitution - Missense	Breast
COSM1586695	c.3672G>T	p.E1224D	Substitution - Missense	Endometrium
COSM1586697	c.4013G>T	p.R1338I	Substitution - Missense	Stomach
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Prostate
COSM4844707	c.5016G>A	p.V1672V	Substitution - coding silent	Cervix
COSM4044300	c.4628C>T	p.P1543L	Substitution - Missense	Stomach
COSM1645716	c.2873T>A	p.L958H	Substitution - Missense	Kidney
COSM4968813	c.3599G>A	p.R1200Q	Substitution - Missense	Central_nervous_system
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4641769	c.690A>G	p.A230A	Substitution - coding silent	Large_intestine
COSM1299804	c.1902G>C	p.K634N	Substitution - Missense	Urinary_tract
COSM4866909	c.5360A>G	p.K1787R	Substitution - Missense	Endometrium
COSM4167627	c.3421G>C	p.V1141L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4746571	c.2719_2730del12	p.N907_E910delNNLE	Deletion - In frame	Stomach
COSM1586678	c.101-1G>T	p.?	Unknown	Endometrium
COSM6000184	c.2601G>T	p.W867C	Substitution - Missense	Prostate
COSM1363750	c.3334T>C	p.F1112L	Substitution - Missense	Stomach
COSM1493050	c.529A>G	p.N177D	Substitution - Missense	Kidney
COSM1476834	c.2965A>T	p.I989F	Substitution - Missense	Breast
COSM1586697	c.4013G>T	p.R1338I	Substitution - Missense	Endometrium
COSM5443636	c.1141G>C	p.E381Q	Substitution - Missense	Oesophagus
COSM1128489	c.3778C>T	p.R1260C	Substitution - Missense	Large_intestine
COSM4044337	c.3079G>A	p.V1027M	Substitution - Missense	Stomach
COSM1363779	c.218delA	p.K73fs*129	Deletion - Frameshift	Biliary_tract
COSM1363779	c.218delA	p.K73fs*129	Deletion - Frameshift	Large_intestine
COSM4671998	c.3395G>A	p.G1132E	Substitution - Missense	Large_intestine
COSM1586690	c.2655C>A	p.F885L	Substitution - Missense	Endometrium
COSM3998921	c.4626A>C	p.T1542T	Substitution - coding silent	Thyroid
COSM1646547	c.2280G>C	p.Q760H	Substitution - Missense	Lung
COSM4210558	c.4026G>T	p.Q1342H	Substitution - Missense	Large_intestine
COSM4495808	c.4613C>T	p.P1538L	Substitution - Missense	Skin
COSM1628795	c.1702C>T	p.Q568*	Substitution - Nonsense	Liver
COSM4874420	c.3293G>A	p.G1098D	Substitution - Missense	Endometrium
COSM3710969	c.4058G>A	p.R1353Q	Substitution - Missense	Upper_aerodigestive_tract
COSM4838274	c.4828G>A	p.E1610K	Substitution - Missense	Cervix
COSM5430312	c.2727G>A	p.L909L	Substitution - coding silent	Oesophagus
COSM1639220	c.3380G>A	p.R1127Q	Substitution - Missense	Oesophagus
COSM5510566	c.4166G>A	p.R1389H	Substitution - Missense	Biliary_tract
COSM4147408	c.1006A>C	p.T336P	Substitution - Missense	Upper_aerodigestive_tract
COSM5510569	c.1407_1409delTTC	p.S470delS	Deletion - In frame	Biliary_tract
COSM5690133	c.5716C>T	p.Q1906*	Substitution - Nonsense	Soft_tissue
COSM5002406	c.414G>T	p.E138D	Substitution - Missense	Pancreas
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM1586691	c.2953T>C	p.Y985H	Substitution - Missense	Endometrium
COSM1248212	c.5339A>C	p.K1780T	Substitution - Missense	Stomach
COSM2098397	c.4107T>C	p.A1369A	Substitution - coding silent	Upper_aerodigestive_tract
COSM2098405	c.4047C>A	p.S1349S	Substitution - coding silent	Upper_aerodigestive_tract
COSM4828622	c.2978A>C	p.N993T	Substitution - Missense	Cervix
COSM1661122	c.1448T>A	p.I483N	Substitution - Missense	Kidney
COSM4489251	c.3450C>T	p.P1150P	Substitution - coding silent	Skin
COSM4841575	c.543C>T	p.F181F	Substitution - coding silent	Cervix
COSM2098602	c.1545T>C	p.S515S	Substitution - coding silent	Large_intestine
COSM1586683	c.830G>A	p.S277N	Substitution - Missense	Endometrium
COSM1363771	c.1039C>T	p.R347*	Substitution - Nonsense	Endometrium
COSM4445640	c.2653-3C>T	p.?	Unknown	Skin
COSM1299798	c.3895G>C	p.E1299Q	Substitution - Missense	Urinary_tract
COSM4147408	c.1006A>C	p.T336P	Substitution - Missense	Oesophagus
COSM1586693	c.3570_3572delGAA	p.K1191delK	Deletion - In frame	Endometrium
COSM3464368	c.3516C>T	p.Y1172Y	Substitution - coding silent	Skin
COSM5749506	c.2795A>G	p.E932G	Substitution - Missense	Genital_tract
COSM5375822	c.265G>A	p.G89R	Substitution - Missense	Skin
COSM4044352	c.1831C>T	p.R611C	Substitution - Missense	Stomach
COSM2098605	c.1542A>G	p.P514P	Substitution - coding silent	Liver
COSM2098497	c.3113G>A	p.G1038D	Substitution - Missense	Large_intestine
COSM4777937	c.2627A>G	p.H876R	Substitution - Missense	Prostate
COSM5933006	c.4236+6T>A	p.?	Unknown	Skin
COSM5802028	c.4353_4370del18	p.S1452_K1457delSEKEFK	Deletion - In frame	Breast
COSM5959253	c.1276G>A	p.D426N	Substitution - Missense	Thyroid
COSM2098524	c.2691G>A	p.K897K	Substitution - coding silent	Large_intestine
COSM1363761	c.1715G>A	p.R572Q	Substitution - Missense	Large_intestine
COSM5947835	c.1872C>A	p.I624I	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4814491	c.3717A>G	p.K1239K	Substitution - coding silent	Breast
COSM2098451	c.3533C>T	p.A1178V	Substitution - Missense	Large_intestine
COSM4672019	c.1622G>A	p.R541Q	Substitution - Missense	Large_intestine
COSM5784433	c.4466G>A	p.R1489H	Substitution - Missense	Breast
COSM5647807	c.4957A>G	p.T1653A	Substitution - Missense	Oesophagus
COSM4044285	c.5272T>C	p.Y1758H	Substitution - Missense	Stomach
COSM3812829	c.3941G>A	p.W1314*	Substitution - Nonsense	Breast
COSM4941199	c.4604C>T	p.S1535L	Substitution - Missense	Liver
COSM3704371	c.1687-5C>G	p.?	Unknown	Liver
COSM4672001	c.3217T>C	p.S1073P	Substitution - Missense	Large_intestine
COSM1586682	c.783G>T	p.K261N	Substitution - Missense	Endometrium
COSM1476831	c.3484C>T	p.R1162W	Substitution - Missense	Endometrium
COSM5750412	c.3386G>A	p.G1129E	Substitution - Missense	Stomach
COSM3676523	c.13C>T	p.L5L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5967968	c.2761C>A	p.P921T	Substitution - Missense	Genital_tract
COSM5044394	c.1438C>T	p.L480F	Substitution - Missense	Adrenal_gland
COSM2098715	c.63T>C	p.D21D	Substitution - coding silent	Stomach
COSM2098515	c.2835_2836insA	p.L946fs*3	Insertion - Frameshift	Large_intestine
COSM5674118	c.1142A>T	p.E381V	Substitution - Missense	Soft_tissue
COSM1476843	c.703G>C	p.A235P	Substitution - Missense	Breast
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Pancreas
COSM3812843	c.2458G>A	p.E820K	Substitution - Missense	Breast
COSM4617412	c.3785A>C	p.Q1262P	Substitution - Missense	Large_intestine
COSM4934358	c.3920A>G	p.E1307G	Substitution - Missense	Liver
COSM1756794	c.5516C>G	p.S1839*	Substitution - Nonsense	Urinary_tract
COSM3464398	c.1926C>T	p.I642I	Substitution - coding silent	Skin
COSM3710972	c.2395C>G	p.P799A	Substitution - Missense	Upper_aerodigestive_tract
COSM5563255	c.3978A>G	p.Q1326Q	Substitution - coding silent	Prostate
COSM5019001	c.417_419delGGA	p.E139delE	Deletion - In frame	Soft_tissue
COSM4044329	c.3530G>A	p.R1177H	Substitution - Missense	Stomach
COSM1363779	c.218delA	p.K73fs*129	Deletion - Frameshift	Small_intestine
COSM5758456	c.4780-10_4780-9insT	p.?	Unknown	Bone
COSM5739558	c.4177C>T	p.R1393W	Substitution - Missense	Small_intestine
COSM4044331	c.3314G>A	p.R1105Q	Substitution - Missense	Ovary
COSM4500531	c.5682C>T	p.S1894S	Substitution - coding silent	Skin
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM4672007	c.2507G>A	p.R836H	Substitution - Missense	Prostate
COSM4610823	c.1097_1098insTGA	p.Y365_E366insD	Insertion - In frame	Large_intestine
COSM5920387	c.4426G>T	p.E1476*	Substitution - Nonsense	Skin
COSM3812840	c.3048G>C	p.K1016N	Substitution - Missense	Breast
COSM1476850	c.269C>A	p.P90Q	Substitution - Missense	Breast
COSM5980245	c.3497A>G	p.N1166S	Substitution - Missense	Upper_aerodigestive_tract
COSM3688407	c.3448C>T	p.P1150S	Substitution - Missense	Large_intestine
COSM3764436	c.3598C>T	p.R1200W	Substitution - Missense	Central_nervous_system
COSM3676520	c.526A>C	p.T176P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1676668	c.3250G>A	p.D1084N	Substitution - Missense	Large_intestine
COSM4957033	c.1421A>G	p.H474R	Substitution - Missense	Liver
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM4942478	c.689C>T	p.A230V	Substitution - Missense	Liver
COSM4147408	c.1006A>C	p.T336P	Substitution - Missense	Upper_aerodigestive_tract
COSM1586684	c.913C>T	p.R305C	Substitution - Missense	Endometrium
COSM1646550	c.3775G>C	p.D1259H	Substitution - Missense	Lung
COSM2098599	c.1579C>T	p.P527S	Substitution - Missense	Skin
COSM1476831	c.3484C>T	p.R1162W	Substitution - Missense	Large_intestine
COSM2098420	c.3909T>A	p.I1303I	Substitution - coding silent	Upper_aerodigestive_tract
COSM4044282	c.5354G>T	p.R1785M	Substitution - Missense	Stomach
COSM4633721	c.2522C>T	p.A841V	Substitution - Missense	Large_intestine
COSM1586679	c.151C>A	p.L51I	Substitution - Missense	Endometrium
COSM3464408	c.1487C>T	p.P496L	Substitution - Missense	Skin
COSM1476839	c.2574C>T	p.D858D	Substitution - coding silent	Breast
COSM5051889	c.288_290delGGA	p.E98delE	Deletion - In frame	Stomach
COSM5789075	c.3840C>G	p.F1280L	Substitution - Missense	Breast
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM5893638	c.4150C>T	p.P1384S	Substitution - Missense	Skin
COSM4044269	c.5671A>G	p.N1891D	Substitution - Missense	Stomach
COSM3872285	c.4890T>C	p.P1630P	Substitution - coding silent	Skin
COSM3872288	c.4109C>T	p.S1370L	Substitution - Missense	Skin
COSM3417077	c.1621C>T	p.R541W	Substitution - Missense	Large_intestine
COSM4044314	c.4104G>T	p.V1368V	Substitution - coding silent	Stomach
COSM1645715	c.2108C>T	p.T703M	Substitution - Missense	Kidney
COSM4834465	c.5259G>A	p.Q1753Q	Substitution - coding silent	Cervix
COSM6014803	c.2226T>C	p.A742A	Substitution - coding silent	Skin
COSM5002406	c.414G>T	p.E138D	Substitution - Missense	Large_intestine
COSM2098420	c.3909T>A	p.I1303I	Substitution - coding silent	Upper_aerodigestive_tract
COSM3710969	c.4058G>A	p.R1353Q	Substitution - Missense	Upper_aerodigestive_tract
COSM4044308	c.4216C>T	p.R1406C	Substitution - Missense	Stomach
COSM4848107	c.1063+1G>A	p.?	Unknown	Cervix
COSM1586686	c.1040G>A	p.R347Q	Substitution - Missense	Endometrium
COSM3464383	c.2528T>C	p.V843A	Substitution - Missense	Skin
COSM1363744	c.4214C>T	p.A1405V	Substitution - Missense	Large_intestine
COSM1363779	c.218delA	p.K73fs*129	Deletion - Frameshift	Large_intestine
COSM3368923	c.4475T>G	p.V1492G	Substitution - Missense	Thyroid
COSM2098491	c.3202C>T	p.R1068C	Substitution - Missense	Oesophagus
COSM1363771	c.1039C>T	p.R347*	Substitution - Nonsense	Pancreas
COSM1756794	c.5516C>G	p.S1839*	Substitution - Nonsense	Urinary_tract
COSM3464355	c.4190A>T	p.D1397V	Substitution - Missense	Skin
COSM1606525	c.4375T>C	p.Y1459H	Substitution - Missense	Liver
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM4672026	c.1143G>A	p.E381E	Substitution - coding silent	Large_intestine
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM5362004	c.857C>T	p.P286L	Substitution - Missense	Large_intestine
COSM4210572	c.3313C>T	p.R1105W	Substitution - Missense	Prostate
COSM5823425	c.2046A>T	p.E682D	Substitution - Missense	Liver
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM1476838	c.2629C>T	p.R877W	Substitution - Missense	Kidney
COSM4871687	c.3485G>A	p.R1162Q	Substitution - Missense	Endometrium
COSM3968400	c.2761C>T	p.P921S	Substitution - Missense	Central_nervous_system
COSM4842473	c.3880-9C>T	p.?	Unknown	Cervix
COSM3739846	c.3280G>A	p.E1094K	Substitution - Missense	Liver
COSM1606531	c.2288T>G	p.V763G	Substitution - Missense	Liver
COSM3676523	c.13C>T	p.L5L	Substitution - coding silent	Large_intestine
COSM1476831	c.3484C>T	p.R1162W	Substitution - Missense	Endometrium
COSM2098293	c.5326G>C	p.E1776Q	Substitution - Missense	Urinary_tract
COSM4817315	c.4061-1G>C	p.?	Unknown	Cervix
COSM1363747	c.3822T>C	p.N1274N	Substitution - coding silent	Large_intestine
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5375813	c.5199T>C	p.H1733H	Substitution - coding silent	Skin
COSM1704964	c.4262G>A	p.R1421Q	Substitution - Missense	Skin
COSM4819395	c.2256G>C	p.E752D	Substitution - Missense	Cervix
COSM1299795	c.3997C>G	p.L1333V	Substitution - Missense	Urinary_tract
COSM4473871	c.187C>T	p.P63S	Substitution - Missense	Skin
COSM1578825	c.2867G>A	p.R956Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1646546	c.2197G>T	p.G733C	Substitution - Missense	Lung
COSM3464411	c.1420C>T	p.H474Y	Substitution - Missense	Skin
COSM4672021	c.1324G>A	p.E442K	Substitution - Missense	Large_intestine
COSM3812846	c.1714C>T	p.R572*	Substitution - Nonsense	Breast
COSM1704973	c.848C>T	p.A283V	Substitution - Missense	Skin
COSM4827363	c.4885G>A	p.E1629K	Substitution - Missense	Cervix
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Large_intestine
COSM5368754	c.3479C>A	p.A1160D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4875131	c.4337G>A	p.R1446K	Substitution - Missense	Endometrium
COSM4870921	c.2375G>A	p.R792Q	Substitution - Missense	Endometrium
COSM2098491	c.3202C>T	p.R1068C	Substitution - Missense	Skin
COSM1363779	c.218delA	p.K73fs*129	Deletion - Frameshift	Large_intestine
COSM5620482	c.640A>G	p.T214A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4671992	c.4673C>T	p.P1558L	Substitution - Missense	Large_intestine
COSM5447049	c.3071T>G	p.L1024R	Substitution - Missense	Large_intestine
COSM5767885	c.3796G>A	p.E1266K	Substitution - Missense	Breast
COSM1299801	c.1923G>C	p.L641F	Substitution - Missense	Urinary_tract
COSM5933003	c.2098C>T	p.P700S	Substitution - Missense	Skin
COSM5933009	c.4236+5G>A	p.?	Unknown	Skin
COSM5027526	c.3447C>A	p.N1149K	Substitution - Missense	Breast
COSM1248209	c.3119A>G	p.Y1040C	Substitution - Missense	Oesophagus
COSM5953216	c.2974C>G	p.R992G	Substitution - Missense	Oesophagus
COSM1645714	c.512A>C	p.D171A	Substitution - Missense	Kidney
COSM5051886	c.1786C>T	p.R596*	Substitution - Nonsense	Stomach
COSM5002406	c.414G>T	p.E138D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1646545	c.1821G>A	p.E607E	Substitution - coding silent	Lung
COSM5970813	c.397_399delAAG	p.K133delK	Deletion - In frame	Upper_aerodigestive_tract
COSM1363776	c.417G>T	p.E139D	Substitution - Missense	Soft_tissue
COSM5743540	c.496G>A	p.V166M	Substitution - Missense	Small_intestine
COSM1639214	c.5217C>T	p.A1739A	Substitution - coding silent	Stomach
COSM4440328	c.3727G>T	p.D1243Y	Substitution - Missense	Thyroid

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
27997699	Mutation	Endometrioid Endometrial Carcinoma	For the first time, we show that mutations in chromatin remodelling-related genes (KMT2D, KMT2C, SETD1B and BCOR) and in DNA-repair-related genes (BRCA1, BRCA2, RAD50 and CHD4) are frequent in this subtype of endometrial cancer.

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q14839	303	S	Phosphoserine	-	No	None detected
Q14839	308	S	Phosphoserine	-	No	None detected
Q14839	309	S	Phosphoserine	-	No	None detected
Q14839	310	S	Phosphoserine	-	No	None detected
Q14839	319	S	Phosphoserine	-	No	None detected
Q14839	367	T	Phosphothreonine	-	No	None detected
Q14839	428	S	Phosphoserine	-	No	None detected
Q14839	515	S	Phosphoserine	-	No	None detected
Q14839	517	T	Phosphothreonine	-	No	None detected
Q14839	529	T	Phosphothreonine	-	No	None detected
Q14839	531	S	Phosphoserine	-	No	None detected
Q14839	703	T	Phosphothreonine	-	No	None detected
Q14839	1209	S	Phosphoserine	-	No	None detected
Q14839	1308	S	Phosphoserine	-	No	None detected
Q14839	1349	S	Phosphoserine	-	No	None detected
Q14839	1531	S	Phosphoserine	-	No	None detected
Q14839	1535	S	Phosphoserine	-	No	None detected
Q14839	1537	S	Phosphoserine	-	No	None detected
Q14839	1542	T	Phosphothreonine	-	No	None detected
Q14839	1549	T	Phosphothreonine	-	No	None detected
Q14839	1553	T	Phosphothreonine	-	No	None detected
Q14839	1570	S	Phosphoserine	-	No	None detected
Q14839	1576	S	Phosphoserine	-	No	None detected
Q14839	1602	S	Phosphoserine	-	Yes	p.S1602L (cancer: LUAD); p.S1602P (cancer: LUAD)
Q14839	1643	K	N6-acetyllysine	-	No	None detected
Q14839	1653	T	Phosphothreonine	-	No	None detected
Q14839	1679	T	Phosphothreonine	-	No	None detected

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	8.287	8.222	-0.047	0.66	NS
BRCA	Breast invasive carcinoma	112	1100	8.026	8.522	0.505	8.49e-41	NS
CESC	Cervical and endocervical cancers	3	306	7.928	7.977	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	7.712	8.053	0.335	6.38e-06	NS
ESCA	Esophageal carcinoma	11	185	8.213	8.216	0.024	0.875	NS
GBM	Glioblastoma multiforme	5	166	7.525	7.909	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	7.802	8.033	0.226	0.00103	NS
KIRC	Kidney renal clear cell carcinoma	72	534	8.303	7.953	-0.339	6.34e-14	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	8.211	8.047	-0.105	0.13	NS
LAML	Acute Myeloid Leukemia	0	173	NA	8.934	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	8.421	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	6.746	7.009	0.289	3.36e-06	NS
LUAD	Lung adenocarcinoma	59	517	7.845	8.093	0.288	5.89e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	7.852	8.167	0.338	6.37e-06	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	8.378	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	8.001	7.924	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.868	8.017	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.707	7.568	-0.096	0.0363	NS
READ	Rectum adenocarcinoma	10	167	7.828	8.024	0.321	0.078	NS
SARC	Sarcoma	2	263	8.03	7.992	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	8.423	8.706	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	7.816	8.028	0.301	3.94e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	8.734	NA	NA	NA
THCA	Thyroid carcinoma	59	509	8.28	8.88	0.62	1.89e-30	Over
THYM	Thymoma	2	120	8.697	8.61	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	8.073	8.228	0.223	0.0097	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.2
Autonomic ganglia	CHP212	9.9
Autonomic ganglia	IMR32	10.1
Autonomic ganglia	KELLY	10.3
Autonomic ganglia	KPNRTBM1	9.6
Autonomic ganglia	KPNSI9S	10.1
Autonomic ganglia	KPNYN	9.9
Autonomic ganglia	MHHNB11	10
Autonomic ganglia	NB1	10.2
Autonomic ganglia	NH6	9.9
Autonomic ganglia	SHSY5Y	9.8
Autonomic ganglia	SIMA	10.5
Autonomic ganglia	SKNAS	10.1
Autonomic ganglia	SKNBE2	10
Autonomic ganglia	SKNDZ	10.4
Autonomic ganglia	SKNFI	10.3
Autonomic ganglia	SKNSH	9.8
Biliary tract	HUCCT1	9.6
Biliary tract	HUH28	9.4
Biliary tract	SNU1079	9.9
Biliary tract	SNU1196	9.6
Biliary tract	SNU245	9.7
Biliary tract	SNU308	10.1
Biliary tract	SNU478	9.7
Bone	143B	9.5
Bone	A673	9.6
Bone	CADOES1	9.5
Bone	CAL78	9.5
Bone	G292CLONEA141B1	9.2
Bone	HOS	9.9
Bone	HS706T	9.6
Bone	HS737T	9.1
Bone	HS819T	8.8
Bone	HS821T	9.2
Bone	HS822T	8.8
Bone	HS863T	8.9
Bone	HS870T	8.7
Bone	HS888T	9.5
Bone	MG63	9.5
Bone	MHHES1	9.4
Bone	OUMS27	9.4
Bone	RDES	10
Bone	SJSA1	9.3
Bone	SKES1	9.5
Bone	SKNMC	10.2
Bone	SW1353	9.8
Bone	T173	8.9
Bone	TC71	9.7
Bone	U2OS	11.2
Breast	AU565	10.6
Breast	BT20	9.9
Breast	BT474	9.8
Breast	BT483	10.3
Breast	BT549	9
Breast	CAL120	9.5
Breast	CAL148	9.7
Breast	CAL51	9.9
Breast	CAL851	9.4
Breast	CAMA1	9.4
Breast	DU4475	10.3
Breast	EFM192A	9.4
Breast	EFM19	10.3
Breast	EVSAT	9.7
Breast	HCC1143	9.9
Breast	HCC1187	10
Breast	HCC1395	9.4
Breast	HCC1419	9.8
Breast	HCC1428	10.2
Breast	HCC1500	8.7
Breast	HCC1569	9.6
Breast	HCC1599	8.5
Breast	HCC1806	9.2
Breast	HCC1937	9.2
Breast	HCC1954	9.5
Breast	HCC202	9.6
Breast	HCC2157	9.4
Breast	HCC2218	9.6
Breast	HCC38	9.3
Breast	HCC70	9.4
Breast	HDQP1	9.4
Breast	HMC18	9.3
Breast	HS274T	9.1
Breast	HS281T	9.2
Breast	HS343T	9.1
Breast	HS578T	8.9
Breast	HS606T	9
Breast	HS739T	9.2
Breast	HS742T	8.3
Breast	JIMT1	9.5
Breast	KPL1	9.9
Breast	MCF7	9.7
Breast	MDAMB134VI	9
Breast	MDAMB157	9
Breast	MDAMB175VII	9.8
Breast	MDAMB231	9.2
Breast	MDAMB361	10.1
Breast	MDAMB415	9.1
Breast	MDAMB436	9.6
Breast	MDAMB453	9.9
Breast	MDAMB468	9.7
Breast	SKBR3	10.3
Breast	T47D	8.9
Breast	UACC812	9.2
Breast	UACC893	9.6
Breast	YMB1	10
Breast	ZR751	9.2
Breast	ZR7530	9.8
Central nervous system	1321N1	10.3
Central nervous system	42MGBA	9.4
Central nervous system	8MGBA	10.1
Central nervous system	A172	9.1
Central nervous system	AM38	9.6
Central nervous system	BECKER	9.3
Central nervous system	CAS1	9.7
Central nervous system	CCFSTTG1	9.3
Central nervous system	D283MED	10.7
Central nervous system	D341MED	9.8
Central nervous system	DAOY	9.9
Central nervous system	DBTRG05MG	9.4
Central nervous system	DKMG	9
Central nervous system	GAMG	9
Central nervous system	GB1	9.8
Central nervous system	GI1	9.9
Central nervous system	GMS10	9.3
Central nervous system	GOS3	9.3
Central nervous system	H4	10.2
Central nervous system	HS683	9.7
Central nervous system	KALS1	9.4
Central nervous system	KG1C	9.4
Central nervous system	KNS42	9.4
Central nervous system	KNS60	9.7
Central nervous system	KNS81	9.4
Central nervous system	KS1	9.8
Central nervous system	LN18	10.5
Central nervous system	LN229	9.8
Central nervous system	M059K	9.5
Central nervous system	MOGGCCM	9.4
Central nervous system	MOGGUVW	10.3
Central nervous system	NMCG1	9
Central nervous system	ONS76	10
Central nervous system	SF126	9.4
Central nervous system	SF295	9.7
Central nervous system	SNB19	9.5
Central nervous system	SNU1105	9.5
Central nervous system	SNU201	9.7
Central nervous system	SNU466	9.2
Central nervous system	SNU489	9.6
Central nervous system	SNU626	9.2
Central nervous system	SNU738	8.4
Central nervous system	SW1088	9.2
Central nervous system	SW1783	9
Central nervous system	T98G	9.7
Central nervous system	TM31	9.7
Central nervous system	U118MG	9.3
Central nervous system	U138MG	9.4
Central nervous system	U251MG	8.5
Central nervous system	U87MG	9.4
Central nervous system	YH13	9.7
Central nervous system	YKG1	9.6
Endometrium	AN3CA	9.5
Endometrium	COLO684	9.7
Endometrium	EFE184	9.2
Endometrium	EN	9.2
Endometrium	ESS1	9.5
Endometrium	HEC108	9.3
Endometrium	HEC151	9.3
Endometrium	HEC1A	9.4
Endometrium	HEC1B	9.3
Endometrium	HEC251	9.4
Endometrium	HEC265	9.7
Endometrium	HEC50B	9.1
Endometrium	HEC59	9.1
Endometrium	HEC6	9.3
Endometrium	ISHIKAWAHERAKLIO02ER	10.1
Endometrium	JHUEM1	9.3
Endometrium	JHUEM2	9.7
Endometrium	JHUEM3	9.2
Endometrium	KLE	9.3
Endometrium	MFE280	9.9
Endometrium	MFE296	9.9
Endometrium	MFE319	9.8
Endometrium	RL952	9
Endometrium	SNGM	8.7
Endometrium	SNU1077	9.9
Endometrium	SNU685	9.2
Endometrium	TEN	9.9
Haematopoietic and lymphoid	697	10.4
Haematopoietic and lymphoid	A3KAW	10.5
Haematopoietic and lymphoid	A4FUK	10.1
Haematopoietic and lymphoid	ALLSIL	10.1
Haematopoietic and lymphoid	AML193	9.8
Haematopoietic and lymphoid	AMO1	10.2
Haematopoietic and lymphoid	BCP1	10.4
Haematopoietic and lymphoid	BDCM	10
Haematopoietic and lymphoid	BL41	10.2
Haematopoietic and lymphoid	BL70	10.3
Haematopoietic and lymphoid	BV173	9.8
Haematopoietic and lymphoid	CA46	9.2
Haematopoietic and lymphoid	CI1	10.1
Haematopoietic and lymphoid	CMK115	10.2
Haematopoietic and lymphoid	CMK86	9.8
Haematopoietic and lymphoid	CMK	10.2
Haematopoietic and lymphoid	CMLT1	10.5
Haematopoietic and lymphoid	COLO775	9.7
Haematopoietic and lymphoid	DAUDI	9.9
Haematopoietic and lymphoid	DB	10.3
Haematopoietic and lymphoid	DEL	9.6
Haematopoietic and lymphoid	DND41	10
Haematopoietic and lymphoid	DOHH2	10.2
Haematopoietic and lymphoid	EB1	9.8
Haematopoietic and lymphoid	EB2	9
Haematopoietic and lymphoid	EHEB	9.3
Haematopoietic and lymphoid	EJM	9.6
Haematopoietic and lymphoid	EM2	9.6
Haematopoietic and lymphoid	EOL1	9.6
Haematopoietic and lymphoid	F36P	10
Haematopoietic and lymphoid	GA10	10.2
Haematopoietic and lymphoid	GDM1	10
Haematopoietic and lymphoid	GRANTA519	9.6
Haematopoietic and lymphoid	HDLM2	9.6
Haematopoietic and lymphoid	HDMYZ	8.9
Haematopoietic and lymphoid	HEL9217	10.5
Haematopoietic and lymphoid	HEL	10.4
Haematopoietic and lymphoid	HH	9.8
Haematopoietic and lymphoid	HL60	10.8
Haematopoietic and lymphoid	HPBALL	10.2
Haematopoietic and lymphoid	HS604T	9.3
Haematopoietic and lymphoid	HS611T	10
Haematopoietic and lymphoid	HS616T	8.9
Haematopoietic and lymphoid	HS751T	8.7
Haematopoietic and lymphoid	HT	10
Haematopoietic and lymphoid	HTK	9.5
Haematopoietic and lymphoid	HUNS1	9.9
Haematopoietic and lymphoid	HUT102	9.4
Haematopoietic and lymphoid	HUT78	10.1
Haematopoietic and lymphoid	JEKO1	10
Haematopoietic and lymphoid	JK1	9.5
Haematopoietic and lymphoid	JM1	10.3
Haematopoietic and lymphoid	JURKAT	10
Haematopoietic and lymphoid	JURLMK1	9.5
Haematopoietic and lymphoid	JVM2	9.4
Haematopoietic and lymphoid	JVM3	9.9
Haematopoietic and lymphoid	K562	9.9
Haematopoietic and lymphoid	KARPAS299	9.9
Haematopoietic and lymphoid	KARPAS422	9.5
Haematopoietic and lymphoid	KARPAS620	10.6
Haematopoietic and lymphoid	KASUMI1	9.8
Haematopoietic and lymphoid	KASUMI2	9.9
Haematopoietic and lymphoid	KASUMI6	9.3
Haematopoietic and lymphoid	KCL22	10.2
Haematopoietic and lymphoid	KE37	9.8
Haematopoietic and lymphoid	KE97	10
Haematopoietic and lymphoid	KG1	10
Haematopoietic and lymphoid	KHM1B	10
Haematopoietic and lymphoid	KIJK	9.6
Haematopoietic and lymphoid	KMH2	10.5
Haematopoietic and lymphoid	KMM1	10.5
Haematopoietic and lymphoid	KMS11	9.8
Haematopoietic and lymphoid	KMS12BM	10.3
Haematopoietic and lymphoid	KMS18	10.1
Haematopoietic and lymphoid	KMS20	10.6
Haematopoietic and lymphoid	KMS21BM	9.5
Haematopoietic and lymphoid	KMS26	10
Haematopoietic and lymphoid	KMS27	9.6
Haematopoietic and lymphoid	KMS28BM	9.3
Haematopoietic and lymphoid	KMS34	9.9
Haematopoietic and lymphoid	KO52	10.2
Haematopoietic and lymphoid	KOPN8	10
Haematopoietic and lymphoid	KU812	10.3
Haematopoietic and lymphoid	KYO1	9.8
Haematopoietic and lymphoid	L1236	10.1
Haematopoietic and lymphoid	L363	9.7
Haematopoietic and lymphoid	L428	9.6
Haematopoietic and lymphoid	L540	8.8
Haematopoietic and lymphoid	LAMA84	10.1
Haematopoietic and lymphoid	LOUCY	10.4
Haematopoietic and lymphoid	LP1	8.9
Haematopoietic and lymphoid	M07E	10.6
Haematopoietic and lymphoid	MC116	10.1
Haematopoietic and lymphoid	ME1	10.1
Haematopoietic and lymphoid	MEC1	9.4
Haematopoietic and lymphoid	MEC2	10.2
Haematopoietic and lymphoid	MEG01	9.8
Haematopoietic and lymphoid	MHHCALL2	10.1
Haematopoietic and lymphoid	MHHCALL3	10
Haematopoietic and lymphoid	MHHCALL4	9.8
Haematopoietic and lymphoid	MINO	10
Haematopoietic and lymphoid	MJ	9.9
Haematopoietic and lymphoid	MM1S	9.7
Haematopoietic and lymphoid	MOLM13	10
Haematopoietic and lymphoid	MOLM16	10.2
Haematopoietic and lymphoid	MOLM6	9.4
Haematopoietic and lymphoid	MOLP2	9.7
Haematopoietic and lymphoid	MOLP8	10.3
Haematopoietic and lymphoid	MOLT13	10.2
Haematopoietic and lymphoid	MOLT16	10.3
Haematopoietic and lymphoid	MOLT4	9.9
Haematopoietic and lymphoid	MONOMAC1	9.6
Haematopoietic and lymphoid	MONOMAC6	9.5
Haematopoietic and lymphoid	MOTN1	9.1
Haematopoietic and lymphoid	MUTZ5	9.8
Haematopoietic and lymphoid	MV411	10.2
Haematopoietic and lymphoid	NALM19	9.7
Haematopoietic and lymphoid	NALM1	9.9
Haematopoietic and lymphoid	NALM6	10
Haematopoietic and lymphoid	NAMALWA	9.9
Haematopoietic and lymphoid	NB4	10.2
Haematopoietic and lymphoid	NCIH929	8.8
Haematopoietic and lymphoid	NCO2	10.1
Haematopoietic and lymphoid	NOMO1	9.4
Haematopoietic and lymphoid	NUDHL1	10.6
Haematopoietic and lymphoid	NUDUL1	10.7
Haematopoietic and lymphoid	OCIAML2	9.2
Haematopoietic and lymphoid	OCIAML3	9.8
Haematopoietic and lymphoid	OCIAML5	9.3
Haematopoietic and lymphoid	OCILY10	10.2
Haematopoietic and lymphoid	OCILY19	9.4
Haematopoietic and lymphoid	OCILY3	9.8
Haematopoietic and lymphoid	OCIM1	10.2
Haematopoietic and lymphoid	OPM2	10.6
Haematopoietic and lymphoid	P12ICHIKAWA	10.3
Haematopoietic and lymphoid	P31FUJ	9.5
Haematopoietic and lymphoid	P3HR1	10.4
Haematopoietic and lymphoid	PCM6	9.7
Haematopoietic and lymphoid	PEER	10.1
Haematopoietic and lymphoid	PF382	10.1
Haematopoietic and lymphoid	PFEIFFER	10.5
Haematopoietic and lymphoid	PL21	9.6
Haematopoietic and lymphoid	RAJI	10.1
Haematopoietic and lymphoid	RCHACV	10.2
Haematopoietic and lymphoid	REC1	9.8
Haematopoietic and lymphoid	REH	9.9
Haematopoietic and lymphoid	RI1	9.6
Haematopoietic and lymphoid	RL	10.7
Haematopoietic and lymphoid	RPMI8226	10.1
Haematopoietic and lymphoid	RPMI8402	10.3
Haematopoietic and lymphoid	RS411	10.5
Haematopoietic and lymphoid	SEM	10.3
Haematopoietic and lymphoid	SET2	10.2
Haematopoietic and lymphoid	SIGM5	9.9
Haematopoietic and lymphoid	SKM1	9.3
Haematopoietic and lymphoid	SKMM2	9.7
Haematopoietic and lymphoid	SR786	9.1
Haematopoietic and lymphoid	ST486	9.8
Haematopoietic and lymphoid	SUDHL10	9.6
Haematopoietic and lymphoid	SUDHL1	9.5
Haematopoietic and lymphoid	SUDHL4	10.2
Haematopoietic and lymphoid	SUDHL5	10.6
Haematopoietic and lymphoid	SUDHL6	10.2
Haematopoietic and lymphoid	SUDHL8	9.9
Haematopoietic and lymphoid	SUPB15	10
Haematopoietic and lymphoid	SUPHD1	10.1
Haematopoietic and lymphoid	SUPM2	9.1
Haematopoietic and lymphoid	SUPT11	9.4
Haematopoietic and lymphoid	SUPT1	10.6
Haematopoietic and lymphoid	TALL1	10
Haematopoietic and lymphoid	TF1	10.2
Haematopoietic and lymphoid	THP1	9.4
Haematopoietic and lymphoid	TO175T	9.1
Haematopoietic and lymphoid	TOLEDO	10.2
Haematopoietic and lymphoid	U266B1	10
Haematopoietic and lymphoid	U937	9.7
Haematopoietic and lymphoid	UT7	9.4
Haematopoietic and lymphoid	WSUDLCL2	9.7
Kidney	769P	9.6
Kidney	786O	9.9
Kidney	A498	9.2
Kidney	A704	8
Kidney	ACHN	8.9
Kidney	BFTC909	9.5
Kidney	CAKI1	9.4
Kidney	CAKI2	9.3
Kidney	CAL54	9.3
Kidney	KMRC1	9.1
Kidney	KMRC20	9.4
Kidney	KMRC2	9.3
Kidney	KMRC3	8.9
Kidney	OSRC2	9.3
Kidney	RCC10RGB	8.4
Kidney	SNU1272	9.4
Kidney	SNU349	9
Kidney	TUHR10TKB	8.6
Kidney	TUHR14TKB	9.2
Kidney	TUHR4TKB	9.3
Kidney	VMRCRCW	9
Kidney	VMRCRCZ	10
Large intestine	C2BBE1	9.3
Large intestine	CCK81	9.9
Large intestine	CL11	9.6
Large intestine	CL14	9.7
Large intestine	CL34	9.4
Large intestine	CL40	9.4
Large intestine	COLO205	9.6
Large intestine	COLO320	10.3
Large intestine	COLO678	9.5
Large intestine	CW2	9.1
Large intestine	DLD1	9.5
Large intestine	GP2D	9.6
Large intestine	HCC56	9.5
Large intestine	HCT116	10.1
Large intestine	HCT15	9.7
Large intestine	HS675T	8.9
Large intestine	HS698T	8.5
Large intestine	HT115	9.6
Large intestine	HT29	9.8
Large intestine	HT55	9.9
Large intestine	KM12	8.4
Large intestine	LOVO	9.4
Large intestine	LS1034	10.3
Large intestine	LS123	9.3
Large intestine	LS180	9.8
Large intestine	LS411N	9.3
Large intestine	LS513	8.9
Large intestine	MDST8	9.3
Large intestine	NCIH508	10
Large intestine	NCIH716	10.1
Large intestine	NCIH747	9.6
Large intestine	OUMS23	10.2
Large intestine	RCM1	10
Large intestine	RKO	9
Large intestine	SKCO1	9.2
Large intestine	SNU1040	9.5
Large intestine	SNU1197	9.5
Large intestine	SNU175	9.2
Large intestine	SNU283	9.6
Large intestine	SNU407	9.5
Large intestine	SNU503	9.9
Large intestine	SNU61	9.6
Large intestine	SNU81	9.5
Large intestine	SNUC1	9.8
Large intestine	SNUC2A	8.8
Large intestine	SNUC4	9.5
Large intestine	SNUC5	9.4
Large intestine	SW1116	9.7
Large intestine	SW1417	9.9
Large intestine	SW1463	9.9
Large intestine	SW403	9.5
Large intestine	SW480	9.5
Large intestine	SW48	9.4
Large intestine	SW620	10.4
Large intestine	SW837	9.9
Large intestine	SW948	9.1
Large intestine	T84	9.7
Liver	ALEXANDERCELLS	9
Liver	C3A	9.4
Liver	HEP3B217	9.5
Liver	HEPG2	9.4
Liver	HLE	9.2
Liver	HLF	9.4
Liver	HUH1	9.2
Liver	HUH6	9.3
Liver	HUH7	9.3
Liver	JHH1	10.1
Liver	JHH2	9.4
Liver	JHH4	10.5
Liver	JHH5	9.8
Liver	JHH6	8.5
Liver	JHH7	9.7
Liver	LI7	10.3
Liver	PLCPRF5	9.3
Liver	SKHEP1	8.8
Liver	SNU182	9.6
Liver	SNU387	9.4
Liver	SNU398	9.8
Liver	SNU423	9
Liver	SNU449	9.1
Liver	SNU475	9.7
Liver	SNU761	9.6
Liver	SNU878	9
Liver	SNU886	9.6
Lung	A549	9.1
Lung	ABC1	9.5
Lung	BEN	10.2
Lung	CAL12T	9.2
Lung	CALU1	9.6
Lung	CALU3	9
Lung	CALU6	10.5
Lung	CHAGOK1	9.2
Lung	COLO668	10.1
Lung	COLO699	9.7
Lung	CORL105	9.2
Lung	CORL23	10
Lung	CORL24	9.1
Lung	CORL279	9.4
Lung	CORL311	9.9
Lung	CORL47	9
Lung	CORL51	9.7
Lung	CORL88	10.6
Lung	CORL95	9.4
Lung	CPCN	9.8
Lung	DMS114	9.5
Lung	DMS153	9.9
Lung	DMS273	10
Lung	DMS454	9.5
Lung	DMS53	10.2
Lung	DMS79	9.9
Lung	DV90	9.5
Lung	EBC1	9.2
Lung	EPLC272H	8.9
Lung	HARA	9.8
Lung	HCC1171	9.3
Lung	HCC1195	9.8
Lung	HCC15	9.4
Lung	HCC2279	9.2
Lung	HCC2935	9.3
Lung	HCC33	10.5
Lung	HCC366	8.5
Lung	HCC4006	9
Lung	HCC44	9.4
Lung	HCC78	9.3
Lung	HCC827	9.2
Lung	HCC95	9.2
Lung	HLC1	8.8
Lung	HLFA	9.1
Lung	HS229T	9
Lung	HS618T	8.9
Lung	IALM	10.3
Lung	KNS62	9.5
Lung	LC1F	9.5
Lung	LC1SQSF	9.2
Lung	LCLC103H	9.9
Lung	LCLC97TM1	9.6
Lung	LK2	10.2
Lung	LOUNH91	9.3
Lung	LU65	9.1
Lung	LU99	9.6
Lung	LUDLU1	9.9
Lung	LXF289	8.8
Lung	MORCPR	10.2
Lung	NCIH1048	9.4
Lung	NCIH1092	9.3
Lung	NCIH1105	9.9
Lung	NCIH1155	10.1
Lung	NCIH1184	9.8
Lung	NCIH1299	9.9
Lung	NCIH1339	10
Lung	NCIH1341	10
Lung	NCIH1355	8.6
Lung	NCIH1373	9.7
Lung	NCIH1385	10
Lung	NCIH1395	9.2
Lung	NCIH1435	9.7
Lung	NCIH1436	9.5
Lung	NCIH1437	9.8
Lung	NCIH146	10.4
Lung	NCIH1563	9.3
Lung	NCIH1568	9
Lung	NCIH1573	9.3
Lung	NCIH1581	9.9
Lung	NCIH1618	10.2
Lung	NCIH1623	9.9
Lung	NCIH1648	10.6
Lung	NCIH1650	9
Lung	NCIH1651	9.5
Lung	NCIH1666	9.4
Lung	NCIH1693	8.3
Lung	NCIH1694	9.9
Lung	NCIH1703	9.8
Lung	NCIH1734	9.9
Lung	NCIH1755	10.1
Lung	NCIH1781	9.7
Lung	NCIH1792	9.8
Lung	NCIH1793	8.7
Lung	NCIH1836	10.2
Lung	NCIH1838	8.9
Lung	NCIH1869	8.7
Lung	NCIH1876	10.2
Lung	NCIH1915	8.3
Lung	NCIH1930	9.7
Lung	NCIH1944	8.3
Lung	NCIH1963	10.2
Lung	NCIH196	9.2
Lung	NCIH1975	9.4
Lung	NCIH2009	9.4
Lung	NCIH2023	9.1
Lung	NCIH2029	9.9
Lung	NCIH2030	9.3
Lung	NCIH2066	9.7
Lung	NCIH2081	10
Lung	NCIH2085	8.9
Lung	NCIH2087	8.7
Lung	NCIH209	10.2
Lung	NCIH2106	8.9
Lung	NCIH2110	8.9
Lung	NCIH211	10.4
Lung	NCIH2122	9.4
Lung	NCIH2126	8.3
Lung	NCIH2141	10.2
Lung	NCIH2170	9.8
Lung	NCIH2171	10.6
Lung	NCIH2172	8.5
Lung	NCIH2196	9.2
Lung	NCIH2227	9.9
Lung	NCIH2228	9.2
Lung	NCIH226	9.3
Lung	NCIH2286	9.7
Lung	NCIH2291	8.7
Lung	NCIH2342	9
Lung	NCIH2347	9.6
Lung	NCIH23	10.1
Lung	NCIH2405	9.2
Lung	NCIH2444	9.6
Lung	NCIH292	8.9
Lung	NCIH322	9.2
Lung	NCIH3255	9.5
Lung	NCIH358	10.3
Lung	NCIH441	10.1
Lung	NCIH446	10.3
Lung	NCIH460	9.1
Lung	NCIH510	9.8
Lung	NCIH520	10.7
Lung	NCIH522	8.7
Lung	NCIH524	10.6
Lung	NCIH526	10.5
Lung	NCIH596	9
Lung	NCIH647	9.7
Lung	NCIH650	9.6
Lung	NCIH661	9.3
Lung	NCIH69	10.3
Lung	NCIH727	9.8
Lung	NCIH810	11
Lung	NCIH82	10.5
Lung	NCIH838	8.7
Lung	NCIH841	9.4
Lung	NCIH854	9.8
Lung	NCIH889	9.6
Lung	PC14	10.1
Lung	RERFLCAD1	9.5
Lung	RERFLCAD2	8.9
Lung	RERFLCAI	9.3
Lung	RERFLCKJ	8.5
Lung	RERFLCMS	9.2
Lung	RERFLCSQ1	9.1
Lung	SBC5	9.8
Lung	SCLC21H	9.9
Lung	SHP77	9.6
Lung	SKLU1	9.4
Lung	SKMES1	9.8
Lung	SQ1	9.5
Lung	SW1271	9.5
Lung	SW1573	8.8
Lung	SW900	9.5
Lung	VMRCLCD	10.2
Lung	VMRCLCP	9.6
Oesophagus	COLO680N	8.9
Oesophagus	ECGI10	9.2
Oesophagus	KYSE140	10
Oesophagus	KYSE150	9.6
Oesophagus	KYSE180	10
Oesophagus	KYSE270	10.4
Oesophagus	KYSE30	10.2
Oesophagus	KYSE410	10
Oesophagus	KYSE450	9
Oesophagus	KYSE510	9.9
Oesophagus	KYSE520	9.4
Oesophagus	KYSE70	8.8
Oesophagus	OE19	9.7
Oesophagus	OE33	9.1
Oesophagus	TE10	10.8
Oesophagus	TE11	9.7
Oesophagus	TE14	9.3
Oesophagus	TE15	10.4
Oesophagus	TE1	9.3
Oesophagus	TE4	9.9
Oesophagus	TE5	8.5
Oesophagus	TE6	9.3
Oesophagus	TE8	10
Oesophagus	TE9	10.1
Oesophagus	TT	10.1
Ovary	59M	9.3
Ovary	A2780	10
Ovary	CAOV3	9.2
Ovary	CAOV4	9.5
Ovary	COLO704	10.3
Ovary	COV318	9.7
Ovary	COV362	9
Ovary	COV434	8.8
Ovary	COV504	9.4
Ovary	COV644	8.8
Ovary	EFO21	8.5
Ovary	EFO27	9.4
Ovary	ES2	9.6
Ovary	FUOV1	10.3
Ovary	HEYA8	9.5
Ovary	HS571T	8.9
Ovary	IGROV1	9.7
Ovary	JHOC5	9.3
Ovary	JHOM1	10.2
Ovary	JHOM2B	9.3
Ovary	JHOS2	9
Ovary	JHOS4	9.1
Ovary	KURAMOCHI	9.8
Ovary	MCAS	9.5
Ovary	NIHOVCAR3	9.8
Ovary	OAW28	9.4
Ovary	OAW42	9.7
Ovary	OC314	9.3
Ovary	OC316	9.2
Ovary	ONCODG1	9.6
Ovary	OV56	8.9
Ovary	OV7	9.1
Ovary	OV90	9.8
Ovary	OVCAR4	9.5
Ovary	OVCAR8	9.3
Ovary	OVISE	9
Ovary	OVK18	9.5
Ovary	OVKATE	8.9
Ovary	OVMANA	9.1
Ovary	OVSAHO	9.9
Ovary	OVTOKO	8.8
Ovary	RMGI	8.8
Ovary	RMUGS	9.6
Ovary	SKOV3	9.3
Ovary	SNU119	9.1
Ovary	SNU840	9.8
Ovary	SNU8	9.8
Ovary	TOV112D	9.9
Ovary	TOV21G	9.8
Ovary	TYKNU	9.1
Pancreas	ASPC1	9.2
Pancreas	BXPC3	9.9
Pancreas	CAPAN1	9.7
Pancreas	CAPAN2	9.1
Pancreas	CFPAC1	9.2
Pancreas	DANG	9.5
Pancreas	HPAC	9.4
Pancreas	HPAFII	9.4
Pancreas	HS766T	9.2
Pancreas	HUPT3	9.6
Pancreas	HUPT4	9.4
Pancreas	KCIMOH1	9.4
Pancreas	KLM1	10
Pancreas	KP2	9.7
Pancreas	KP3	8.5
Pancreas	KP4	9.7
Pancreas	L33	9.7
Pancreas	MIAPACA2	10.2
Pancreas	PANC0203	9.5
Pancreas	PANC0213	9.5
Pancreas	PANC0327	9.7
Pancreas	PANC0403	9.5
Pancreas	PANC0504	9.5
Pancreas	PANC0813	9.5
Pancreas	PANC1005	9.6
Pancreas	PANC1	8.7
Pancreas	PATU8902	9.5
Pancreas	PATU8988S	8.9
Pancreas	PATU8988T	8.9
Pancreas	PK1	9.2
Pancreas	PK45H	9.3
Pancreas	PK59	9.6
Pancreas	PL45	9.3
Pancreas	PSN1	9.7
Pancreas	QGP1	9.9
Pancreas	SNU213	9.1
Pancreas	SNU324	9.2
Pancreas	SNU410	9.4
Pancreas	SU8686	9
Pancreas	SUIT2	8.7
Pancreas	SW1990	9.1
Pancreas	T3M4	9.7
Pancreas	TCCPAN2	9.3
Pancreas	YAPC	9.9
Pleura	ACCMESO1	7.8
Pleura	DM3	8.6
Pleura	ISTMES1	9.3
Pleura	ISTMES2	9.3
Pleura	JL1	9.3
Pleura	MPP89	9.1
Pleura	MSTO211H	9.2
Pleura	NCIH2052	9.1
Pleura	NCIH2452	9.5
Pleura	NCIH28	9.7
Prostate	22RV1	8.9
Prostate	DU145	9
Prostate	LNCAPCLONEFGC	9.1
Prostate	MDAPCA2B	9.5
Prostate	NCIH660	9.4
Prostate	PC3	9
Prostate	VCAP	9.6
Salivary gland	A253	9
Salivary gland	YD15	9.6
Skin	A101D	9.7
Skin	A2058	9.6
Skin	A375	10.2
Skin	C32	9.5
Skin	CHL1	10
Skin	CJM	9
Skin	COLO679	10.8
Skin	COLO741	9.6
Skin	COLO783	9.3
Skin	COLO792	8.8
Skin	COLO800	9.9
Skin	COLO818	9.3
Skin	COLO829	10.1
Skin	COLO849	10.2
Skin	G361	9.9
Skin	GRM	9.5
Skin	HMCB	10
Skin	HS294T	10
Skin	HS600T	8.8
Skin	HS688AT	9.1
Skin	HS695T	9.8
Skin	HS839T	9
Skin	HS852T	9.3
Skin	HS895T	8.3
Skin	HS934T	9.1
Skin	HS936T	9.7
Skin	HS939T	9.7
Skin	HS940T	9.1
Skin	HS944T	9.7
Skin	HT144	9.7
Skin	IGR1	9.9
Skin	IGR37	9.7
Skin	IGR39	9.5
Skin	IPC298	9.9
Skin	K029AX	10
Skin	LOXIMVI	9.9
Skin	MALME3M	9.8
Skin	MDAMB435S	9.3
Skin	MELHO	10.1
Skin	MELJUSO	9.9
Skin	MEWO	9.4
Skin	RPMI7951	9.5
Skin	RVH421	9.1
Skin	SH4	9.1
Skin	SKMEL1	9.6
Skin	SKMEL24	9.7
Skin	SKMEL28	9.5
Skin	SKMEL2	10
Skin	SKMEL30	9.7
Skin	SKMEL31	9.8
Skin	SKMEL3	9.7
Skin	SKMEL5	9.5
Skin	UACC257	9.6
Skin	UACC62	10
Skin	WM115	9.4
Skin	WM1799	9.3
Skin	WM2664	9.5
Skin	WM793	9.4
Skin	WM88	9.4
Skin	WM983B	9
Small intestine	HUTU80	9.6
Soft tissue	A204	9.1
Soft tissue	G401	10.7
Soft tissue	G402	9.5
Soft tissue	GCT	10.1
Soft tissue	HS729	9.5
Soft tissue	HT1080	10
Soft tissue	KYM1	10
Soft tissue	MESSA	10.2
Soft tissue	RD	9.7
Soft tissue	RH30	9.6
Soft tissue	RH41	9.4
Soft tissue	RKN	9.5
Soft tissue	S117	9.8
Soft tissue	SJRH30	10.3
Soft tissue	SKLMS1	9.2
Soft tissue	SKUT1	9.6
Soft tissue	TE125T	8.2
Soft tissue	TE159T	8.8
Soft tissue	TE441T	9.5
Soft tissue	TE617T	9.3
Stomach	2313287	9.5
Stomach	AGS	9.6
Stomach	AZ521	9.6
Stomach	ECC10	10
Stomach	ECC12	9.9
Stomach	FU97	10
Stomach	GCIY	9.5
Stomach	GSS	9.6
Stomach	GSU	9.4
Stomach	HGC27	10.4
Stomach	HS746T	9.4
Stomach	HUG1N	9.2
Stomach	IM95	9
Stomach	KATOIII	9.4
Stomach	KE39	9.6
Stomach	LMSU	9.8
Stomach	MKN1	9.7
Stomach	MKN45	10
Stomach	MKN74	8.7
Stomach	MKN7	9.1
Stomach	NCCSTCK140	9.9
Stomach	NCIN87	10.1
Stomach	NUGC2	9.8
Stomach	NUGC3	9.5
Stomach	NUGC4	9.9
Stomach	OCUM1	9.6
Stomach	RERFGC1B	10
Stomach	SH10TC	10.1
Stomach	SNU16	9.6
Stomach	SNU1	9.5
Stomach	SNU216	9.2
Stomach	SNU520	9.4
Stomach	SNU5	8.9
Stomach	SNU601	9.3
Stomach	SNU620	9.2
Stomach	SNU668	9.3
Stomach	SNU719	9.9
Stomach	TGBC11TKB	9.4
Thyroid	8305C	9
Thyroid	8505C	9.3
Thyroid	BCPAP	10.6
Thyroid	BHT101	10.7
Thyroid	CAL62	9.9
Thyroid	CGTHW1	9.3
Thyroid	FTC133	9.6
Thyroid	FTC238	8.8
Thyroid	ML1	9.9
Thyroid	SW579	9.5
Thyroid	TT2609C02	9.9
Thyroid	TT	10.3
Upper aerodigestive tract	BHY	9.6
Upper aerodigestive tract	BICR16	9.3
Upper aerodigestive tract	BICR18	9.8
Upper aerodigestive tract	BICR22	9.3
Upper aerodigestive tract	BICR31	9.1
Upper aerodigestive tract	BICR56	9.7
Upper aerodigestive tract	BICR6	9.6
Upper aerodigestive tract	CAL27	10.2
Upper aerodigestive tract	CAL33	9.2
Upper aerodigestive tract	DETROIT562	9.2
Upper aerodigestive tract	FADU	9.8
Upper aerodigestive tract	HS840T	9
Upper aerodigestive tract	HSC2	9.5
Upper aerodigestive tract	HSC3	9.4
Upper aerodigestive tract	HSC4	9.3
Upper aerodigestive tract	PECAPJ15	9.3
Upper aerodigestive tract	PECAPJ34CLONEC12	9.5
Upper aerodigestive tract	PECAPJ41CLONED2	9.3
Upper aerodigestive tract	PECAPJ49	9.7
Upper aerodigestive tract	SCC15	9.1
Upper aerodigestive tract	SCC25	9.2
Upper aerodigestive tract	SCC4	9.9
Upper aerodigestive tract	SCC9	9
Upper aerodigestive tract	SNU1076	9.3
Upper aerodigestive tract	SNU1214	9.1
Upper aerodigestive tract	SNU46	9.8
Upper aerodigestive tract	SNU899	9.7
Upper aerodigestive tract	YD10B	9.7
Upper aerodigestive tract	YD38	10.1
Upper aerodigestive tract	YD8	9.2
Urinary tract	5637	9.7
Urinary tract	639V	10.3
Urinary tract	647V	9.8
Urinary tract	BC3C	9.4
Urinary tract	BFTC905	10
Urinary tract	CAL29	9
Urinary tract	HS172T	8.4
Urinary tract	HT1197	9.3
Urinary tract	HT1376	9.3
Urinary tract	J82	9.4
Urinary tract	JMSU1	9.9
Urinary tract	KMBC2	9.4
Urinary tract	KU1919	9.8
Urinary tract	RT11284	9.8
Urinary tract	RT112	9.9
Urinary tract	RT4	9.4
Urinary tract	SCABER	10.1
Urinary tract	SW1710	9.1
Urinary tract	SW780	9.3
Urinary tract	T24	9.5
Urinary tract	TCCSUP	8.6
Urinary tract	UMUC1	9.3
Urinary tract	UMUC3	9.5
Urinary tract	VMCUB1	9.8

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	36
Adrenal gland	38.9
Appendix	51.3
Bone marrow	39
Breast	35.9
Cerebral cortex	55.1
Cervix, uterine	50.9
Colon	31.9
Duodenum	29.3
Endometrium	72.6
Epididymis	59.9
Esophagus	32.4
Fallopian tube	61.2
Gallbladder	52.3
Heart muscle	28.2
Kidney	41
Liver	16.7
Lung	53
Lymph node	56.8
Ovary	51.5
Pancreas	6.9
Parathyroid gland	117.2
Placenta	60.4
Prostate	45.1
Rectum	38.6
Salivary gland	12.5
Seminal vesicle	61.5
Skeletal muscle	13.4
Skin	56.3
Small intestine	29.6
Smooth muscle	69.3
Spleen	50.4
Stomach	32.1
Testis	64.8
Thyroid gland	90.2
Tonsil	52.5
Urinary bladder	42.8

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26095183	Overexpression	Hepatocellular Carcinoma	CHD4 was abundantly expressed in EpCAM(+) hepatocellular carcinoma with expression of hepatic stem cell markers and poor prognosis in two independent cohorts.
21447119	Loss of expression	Colorectal Carcinoma; Gastric Carcinoma	Loss of CHD4 expression was observed in 56.4% of the GCs and 55.7% of the CRCs.

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.389	5.12e-16	12.4	55	32.7	Neutral
BRCA	Breast invasive carcinoma	1075	0.304	1.99e-24	14.1	60.7	25.2	Neutral
CESC	Cervical and endocervical cancers	292	0.399	1.35e-12	15.1	65.1	19.9	Neutral
COAD	Colon adenocarcinoma	449	0.23	8.28e-07	10.9	66.4	22.7	Neutral
ESCA	Esophageal carcinoma	183	0.361	5.31e-07	18.6	48.1	33.3	Neutral
GBM	Glioblastoma multiforme	147	0.215	0.00893	8.2	78.9	12.9	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.381	3.71e-19	7.4	60.9	31.7	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.193	8.58e-06	1	75.8	23.2	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.092	0.118	0.7	60.1	39.2	Gain
LAML	Acute Myeloid Leukemia	166	0.047	0.549	1.8	98.2	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.48	7.35e-31	3.9	82.7	13.5	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.376	1.13e-13	21.2	67.3	11.5	Neutral
LUAD	Lung adenocarcinoma	512	0.233	9.09e-08	25	46.5	28.5	Neutral
LUSC	Lung squamous cell carcinoma	498	0.262	3.01e-09	7.4	42	50.6	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.394	1.47e-12	14.3	33.3	52.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.555	1.11e-15	13.6	67.8	18.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.147	0.0611	1.2	91.4	7.4	Neutral
PRAD	Prostate adenocarcinoma	491	0.085	0.0584	14.9	82.1	3.1	Neutral
READ	Rectum adenocarcinoma	164	0.185	0.018	12.8	64.6	22.6	Neutral
SARC	Sarcoma	255	0.47	1.93e-15	30.2	52.2	17.6	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.343	1.38e-11	15.8	65.7	18.5	Neutral
STAD	Stomach adenocarcinoma	413	0.201	3.96e-05	16	60.3	23.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.583	4.74e-15	0	2	98	Gain
THCA	Thyroid carcinoma	497	-0.032	0.483	0.2	97.2	2.6	Neutral
THYM	Thymoma	119	0.19	0.0383	5.9	90.8	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.339	6.51e-16	7.3	75.4	17.3	Neutral

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.239	6.66e-07	17	408	-0.062	2.49e-06	NS/NA
BRCA	Breast invasive carcinoma	-0.138	4.38e-05	83	785	0.003	0.169	NS/NA
CESC	Cervical and endocervical cancers	-0.305	5.02e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.299	6.99e-08	19	297	0	0.871	NS/NA
ESCA	Esophageal carcinoma	-0.314	9.1e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.116	0.358	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.231	5.95e-08	20	522	-0.005	0.0953	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.147	0.00649	24	319	0	0.535	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.275	1.51e-06	23	275	0.008	0.57	NS/NA
LAML	Acute Myeloid Leukemia	-0.171	0.0262	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.2	3.7e-06	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.201	3.98e-05	41	373	0.003	0.000843	NS/NA
LUAD	Lung adenocarcinoma	-0.113	0.0135	21	456	-0.011	0.109	NS/NA
LUSC	Lung squamous cell carcinoma	-0.291	1e-08	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.683	0.0503	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.204	0.00558	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.17	0.0198	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.238	3.01e-08	35	498	0.007	8.45e-10	NS/NA
READ	Rectum adenocarcinoma	-0.193	0.0537	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.291	1.82e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.133	0.00388	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.242	2.57e-06	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.529	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.574	0	50	509	-0.081	3.52e-26	NS/NA
THYM	Thymoma	-0.232	0.0104	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.245	9.88e-08	34	431	-0.001	0.58	NS/NA

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	2	Medium
Epididymis	2	Medium
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	1	Low
Lung	2	Medium
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	1	Low
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	2	Medium
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.618	NS	24476821
BRCA	Breast invasive carcinoma	521	0.000233	Significant	23000897
COAD	Colon adenocarcinoma	149	0.735	NS	22810696
GBM	Glioblastoma multiforme	157	0.000374	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.952	NS	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.000605	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.24e-18	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.773	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.00811	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	4.13e-09	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.000565	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0632	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.096	NS	26091043
STAD	Stomach adenocarcinoma	277	0.00364	Significant	25079317
THCA	Thyroid carcinoma	391	2.46e-23	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	2.52e-10	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.349	0.149	NS
BRCA	Breast invasive carcinoma	1079	1.148	0.561	NS
CESC	Cervical and endocervical cancers	291	0.769	0.442	NS
COAD	Colon adenocarcinoma	439	1.243	0.448	NS
ESCA	Esophageal carcinoma	184	1.207	0.578	NS
GBM	Glioblastoma multiforme	158	0.765	0.284	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.418	0.0571	NS
KIRC	Kidney renal clear cell carcinoma	531	0.733	0.154	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.851	0.141	NS
LAML	Acute Myeloid Leukemia	149	0.722	0.267	NS
LGG	Brain Lower Grade Glioma	511	0.49	0.00438	Longer
LIHC	Liver hepatocellular carcinoma	365	1.469	0.115	NS
LUAD	Lung adenocarcinoma	502	0.877	0.523	NS
LUSC	Lung squamous cell carcinoma	494	0.937	0.732	NS
OV	Ovarian serous cystadenocarcinoma	303	1.507	0.0544	NS
PAAD	Pancreatic adenocarcinoma	177	0.814	0.486	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.421	0.441	NS
PRAD	Prostate adenocarcinoma	497	1.145	0.884	NS
READ	Rectum adenocarcinoma	159	1.016	0.975	NS
SARC	Sarcoma	259	1.751	0.0398	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.78	0.00315	Shorter
STAD	Stomach adenocarcinoma	388	1.003	0.991	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.404	0.151	NS
THYM	Thymoma	119	0	0.00276	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	2.706	0.00104	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.052	0.295	NS
BRCA	Breast invasive carcinoma	1071	0.019	0.533	NS
CESC	Cervical and endocervical cancers	167	0.055	0.48	NS
COAD	Colon adenocarcinoma	445	0.014	0.764	NS
ESCA	Esophageal carcinoma	162	-0.018	0.823	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.072	0.129	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.084	0.0521	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.212	0.000565	Higher
LIHC	Liver hepatocellular carcinoma	347	0.12	0.0248	Higher
LUAD	Lung adenocarcinoma	507	0.077	0.0831	NS
LUSC	Lung squamous cell carcinoma	497	0.058	0.2	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.041	0.483	NS
PAAD	Pancreatic adenocarcinoma	176	-0.004	0.957	NS
READ	Rectum adenocarcinoma	156	0.039	0.633	NS
SKCM	Skin Cutaneous Melanoma	410	-0.105	0.033	Lower
STAD	Stomach adenocarcinoma	392	0.017	0.737	NS
TGCT	Testicular Germ Cell Tumors	81	0.301	0.0063	Higher
THCA	Thyroid carcinoma	499	0.116	0.0094	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.117	0.00891	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.084	0.169	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.031	0.486	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.017	0.698	NS
LGG	Brain Lower Grade Glioma	514	0.037	0.404	NS
LIHC	Liver hepatocellular carcinoma	366	0.133	0.011	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.099	0.0885	NS
PAAD	Pancreatic adenocarcinoma	176	0.027	0.723	NS
STAD	Stomach adenocarcinoma	406	-0.087	0.0807	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.325	1.4e-14	Higher

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for CHD4.

Summary
Symbol	CHD4
Name	chromodomain helicase DNA binding protein 4
Aliases	Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Chromodomain-helicase ......
Location	12p13.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for CHD4.