CR2Cancer

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF08074 CHDCT2 (NUC038) domain
PF08073 CHDNT (NUC034) domain
PF00385 Chromo (CHRromatin Organisation MOdifier) domain
PF06461 Domain of Unknown Function (DUF1086)
PF06465 Domain of Unknown Function (DUF1087)
PF00271 Helicase conserved C-terminal domain
PF00628 PHD-finger
PF00176 SNF2 family N-terminal domain

Function

Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	H3K27me3, H3K4	#	12592387

> Gene Ontology [ TOP ]
Biological Process	GO:0006323 DNA packaging GO:0006338 chromatin remodeling GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006479 protein methylation GO:0006997 nucleus organization GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007289 spermatid nucleus differentiation GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0016573 histone acetylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0021895 cerebral cortex neuron differentiation GO:0021953 central nervous system neuron differentiation GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030900 forebrain development GO:0032259 methylation GO:0034728 nucleosome organization GO:0034968 histone lysine methylation GO:0035092 sperm chromatin condensation GO:0035093 spermatogenesis, exchange of chromosomal proteins GO:0043044 ATP-dependent chromatin remodeling GO:0043414 macromolecule methylation GO:0043486 histone exchange GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0045165 cell fate commitment GO:0048232 male gamete generation GO:0048515 spermatid differentiation GO:0060850 regulation of transcription involved in cell fate commitment GO:0070734 histone H3-K27 methylation GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization GO:0072331 signal transduction by p53 class mediator GO:0098532 histone H3-K27 trimethylation GO:1901796 regulation of signal transduction by p53 class mediator GO:1901798 positive regulation of signal transduction by p53 class mediator
Molecular Function	GO:0004386 helicase activity GO:0008026 ATP-dependent helicase activity GO:0016887 ATPase activity GO:0035064 methylated histone binding GO:0042393 histone binding GO:0042623 ATPase activity, coupled GO:0061628 H3K27me3 modified histone binding GO:0070035 purine NTP-dependent helicase activity
Cellular Component	GO:0000118 histone deacetylase complex GO:0000785 chromatin GO:0000792 heterochromatin GO:0016581 NuRD complex GO:0017053 transcriptional repressor complex GO:0070603 SWI/SNF superfamily-type complex GO:0090545 CHD-type complex GO:0090568 nuclear transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM112104	c.1391_1392insC	p.L465fs*28	Insertion - Frameshift	Ovary
COSM107121	c.5109C>T	p.F1703F	Substitution - coding silent	Skin
COSM83866	c.5622C>T	p.D1874D	Substitution - coding silent	Pancreas
COSM32473	c.355G>A	p.D119N	Substitution - Missense	Breast
COSM32706	c.133G>A	p.V45M	Substitution - Missense	Breast
COSM88525	c.3772G>C	p.D1258H	Substitution - Missense	Ovary
COSM70168	c.3499A>G	p.M1167V	Substitution - Missense	Ovary
COSM27188	c.3917G>T	p.R1306L	Substitution - Missense	Lung
COSM131045	c.1972A>G	p.R658G	Substitution - Missense	Liver
COSM111957	c.3969_3970insAT	p.L1324fs*78	Insertion - Frameshift	Ovary
COSM33237	c.1999A>G	p.R667G	Substitution - Missense	Breast
COSM127627	c.108C>T	p.F36F	Substitution - coding silent	Upper_aerodigestive_tract
COSM39367	c.5199C>T	p.Y1733Y	Substitution - coding silent	Central_nervous_system
COSM27188	c.3917G>T	p.R1306L	Substitution - Missense	Lung
COSM97935	c.898G>C	p.D300H	Substitution - Missense	Upper_aerodigestive_tract

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
25825869	Mutation	Neuroblastoma	CHD5 (chromodomain helicase DNA-binding protein 5) is a tumour suppressor gene (TSG) that maps to a region of consistent deletion on 1p36.31in neuroblastomas (NBs) and other tumour types.
22569290	Mutation; Underexpression (hypermethylation)	Breast Carcinoma	Although only one mutation was detected, CHD5 mRNA expression was significantly reduced, accompanied by frequent genomic deletion and promoter methylation, in breast cancer.
22294723	Mutation; Loss of Expression (hypermethylation); Deletion; Underexpression (hypermethylation)	Neuroblastoma	We conclude that (i) somatically acquired CHD5 mutations are rare in primary NBs, so inactivation probably occurs by deletion and epigenetic silencing; (ii) CHD5 expression and promoter methylation are associated with MYCN amplification, suggesting a possible interaction between these 2 genes; and (iii) high CHD5 expression is strongly correlated with favorable clinical/biological features and outcome.
21147910	Mutation	Prostate Carcinoma	Furthermore, targeted mutational analysis of normal-tumor pairs has identified somatic mutations in genes known to be associated with prostate cancer including AR and TP53, but has also revealed novel somatic point mutations in genes including MTOR, BRCA2, ARHGEF12, and CHD5.
18953434	Mutation	Ovarian Carcinoma; Breast Carcinoma	We analyzed all 41 coding exons of CHD5 for somatic mutations in 123 primary ovarian cancers as well as 60 primary breast cancers using high-resolution melt analysis.
18672103	Mutation	Neuroblastoma	Among the best candidate genes predisposing to the development of neuroblastoma located in 1p36, the AJAP1 gene is the only gene present in the duplication while CHD5, TNFRSF25 and CAMTA1 are located outside of the rearrangement. Therefore, a gene-dosage effect involving a gene located in the duplication including AJAP1 might explain the neuroblastoma observed in our patient. The rearrangement might equally interfere with the expression of a gene located outside of it (including CHD5 located 1Mb away from the rearrangement) playing a role in the tumorigenesis.

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	-0.555	-3.444	-3.465	8.53e-14	Under
BRCA	Breast invasive carcinoma	112	1100	-2.438	-2.912	-0.286	0.159	NS
CESC	Cervical and endocervical cancers	3	306	-1.989	-3.246	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	-0.562	-2.034	-1.558	1.54e-08	Under
ESCA	Esophageal carcinoma	11	185	0.007	-2.112	-2.981	0.00072	Under
GBM	Glioblastoma multiforme	5	166	8.945	1.548	NA	NA	NA
KIRC	Kidney renal clear cell carcinoma	72	534	0.453	-3.429	-3.651	3.65e-38	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	1.033	-2.314	-2.867	3.19e-07	Under
LAML	Acute Myeloid Leukemia	0	173	NA	0.806	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.256	NA	NA	NA
LUSC	Lung squamous cell carcinoma	51	501	-1.733	-3.314	-1.263	9.76e-06	Under
PAAD	Pancreatic adenocarcinoma	4	179	-1.402	-0.247	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-2.122	4.894	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	1.791	0.205	-1.513	1.08e-13	Under
READ	Rectum adenocarcinoma	10	167	-0.416	-2.055	-1.571	0.0062	Under
SARC	Sarcoma	2	263	0.246	-1.714	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	-0.171	-1.59	-1.588	0.000186	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	0.641	NA	NA	NA
THCA	Thyroid carcinoma	59	509	-2.364	-1.374	1.066	7.94e-07	Over
THYM	Thymoma	2	120	0.505	1.822	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	-1.178	-2.573	-1.642	1.08e-06	Under

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	4.7
Autonomic ganglia	CHP212	4
Autonomic ganglia	IMR32	4.4
Autonomic ganglia	KELLY	4
Autonomic ganglia	KPNRTBM1	4.6
Autonomic ganglia	KPNSI9S	4.2
Autonomic ganglia	KPNYN	4.4
Autonomic ganglia	MHHNB11	4.3
Autonomic ganglia	NB1	4.1
Autonomic ganglia	NH6	4.6
Autonomic ganglia	SHSY5Y	4.8
Autonomic ganglia	SIMA	4.2
Autonomic ganglia	SKNAS	4.1
Autonomic ganglia	SKNBE2	3.9
Autonomic ganglia	SKNDZ	4
Autonomic ganglia	SKNFI	4.3
Autonomic ganglia	SKNSH	4.3
Biliary tract	HUCCT1	3.8
Biliary tract	HUH28	4.6
Biliary tract	SNU1079	4.5
Biliary tract	SNU1196	4.1
Biliary tract	SNU245	4.1
Biliary tract	SNU308	4.3
Biliary tract	SNU478	4.1
Bone	143B	4.4
Bone	A673	4.1
Bone	CADOES1	4.9
Bone	CAL78	4
Bone	G292CLONEA141B1	4.1
Bone	HOS	4.5
Bone	HS706T	4.1
Bone	HS737T	4.2
Bone	HS819T	4
Bone	HS821T	4
Bone	HS822T	3.9
Bone	HS863T	4
Bone	HS870T	4.4
Bone	HS888T	3.8
Bone	MG63	4.4
Bone	MHHES1	3.8
Bone	OUMS27	4
Bone	RDES	4.1
Bone	SJSA1	4.3
Bone	SKES1	4.1
Bone	SKNMC	4.2
Bone	SW1353	4
Bone	T173	4.2
Bone	TC71	4.3
Bone	U2OS	5
Breast	AU565	4.2
Breast	BT20	4.2
Breast	BT474	4
Breast	BT483	4.2
Breast	BT549	4.3
Breast	CAL120	4
Breast	CAL148	4
Breast	CAL51	4
Breast	CAL851	4.2
Breast	CAMA1	4.2
Breast	DU4475	4.2
Breast	EFM192A	4.3
Breast	EFM19	4.9
Breast	EVSAT	4.1
Breast	HCC1143	5.1
Breast	HCC1187	4
Breast	HCC1395	4
Breast	HCC1419	4.2
Breast	HCC1428	4.2
Breast	HCC1500	4.2
Breast	HCC1569	4
Breast	HCC1599	4.1
Breast	HCC1806	4.3
Breast	HCC1937	4.3
Breast	HCC1954	4
Breast	HCC202	4.2
Breast	HCC2157	4.7
Breast	HCC2218	4.2
Breast	HCC38	4.4
Breast	HCC70	4.2
Breast	HDQP1	4.5
Breast	HMC18	4.6
Breast	HS274T	4
Breast	HS281T	4
Breast	HS343T	4
Breast	HS578T	4.1
Breast	HS606T	4.1
Breast	HS739T	4.1
Breast	HS742T	4.2
Breast	JIMT1	4.1
Breast	KPL1	4.9
Breast	MCF7	4.5
Breast	MDAMB134VI	4.4
Breast	MDAMB157	4.6
Breast	MDAMB175VII	4.1
Breast	MDAMB231	4.2
Breast	MDAMB361	4
Breast	MDAMB415	4.2
Breast	MDAMB436	4.1
Breast	MDAMB453	3.9
Breast	MDAMB468	4.1
Breast	SKBR3	4.2
Breast	T47D	4.4
Breast	UACC812	4.5
Breast	UACC893	4.7
Breast	YMB1	4.3
Breast	ZR751	3.9
Breast	ZR7530	4.4
Central nervous system	1321N1	3.9
Central nervous system	42MGBA	4.1
Central nervous system	8MGBA	3.9
Central nervous system	A172	4.2
Central nervous system	AM38	4.1
Central nervous system	BECKER	4.4
Central nervous system	CAS1	4.3
Central nervous system	CCFSTTG1	4
Central nervous system	D283MED	4
Central nervous system	D341MED	5.1
Central nervous system	DAOY	4.1
Central nervous system	DBTRG05MG	3.9
Central nervous system	DKMG	4.2
Central nervous system	GAMG	4.1
Central nervous system	GB1	4.1
Central nervous system	GI1	4.1
Central nervous system	GMS10	3.9
Central nervous system	GOS3	4.4
Central nervous system	H4	4
Central nervous system	HS683	3.9
Central nervous system	KALS1	4.2
Central nervous system	KG1C	3.9
Central nervous system	KNS42	4
Central nervous system	KNS60	4
Central nervous system	KNS81	4
Central nervous system	KS1	3.9
Central nervous system	LN18	3.9
Central nervous system	LN229	3.9
Central nervous system	M059K	4.2
Central nervous system	MOGGCCM	4.1
Central nervous system	MOGGUVW	4
Central nervous system	NMCG1	3.7
Central nervous system	ONS76	4.5
Central nervous system	SF126	4.1
Central nervous system	SF295	4
Central nervous system	SNB19	4
Central nervous system	SNU1105	4.1
Central nervous system	SNU201	4.2
Central nervous system	SNU466	4.1
Central nervous system	SNU489	4
Central nervous system	SNU626	5.8
Central nervous system	SNU738	4.3
Central nervous system	SW1088	4
Central nervous system	SW1783	3.9
Central nervous system	T98G	3.9
Central nervous system	TM31	3.9
Central nervous system	U118MG	3.9
Central nervous system	U138MG	3.8
Central nervous system	U251MG	4
Central nervous system	U87MG	4.1
Central nervous system	YH13	3.8
Central nervous system	YKG1	3.9
Endometrium	AN3CA	4.2
Endometrium	COLO684	6.3
Endometrium	EFE184	4.5
Endometrium	EN	5
Endometrium	ESS1	4.2
Endometrium	HEC108	4.7
Endometrium	HEC151	4.3
Endometrium	HEC1A	4
Endometrium	HEC1B	4.2
Endometrium	HEC251	4.1
Endometrium	HEC265	4.3
Endometrium	HEC50B	4.3
Endometrium	HEC59	4.3
Endometrium	HEC6	4.5
Endometrium	ISHIKAWAHERAKLIO02ER	4.1
Endometrium	JHUEM1	4
Endometrium	JHUEM2	3.9
Endometrium	JHUEM3	3.9
Endometrium	KLE	4.5
Endometrium	MFE280	4.5
Endometrium	MFE296	4.1
Endometrium	MFE319	4.2
Endometrium	RL952	4
Endometrium	SNGM	4.2
Endometrium	SNU1077	3.9
Endometrium	SNU685	4
Endometrium	TEN	4.1
Haematopoietic and lymphoid	697	4.2
Haematopoietic and lymphoid	A3KAW	4.3
Haematopoietic and lymphoid	A4FUK	4.1
Haematopoietic and lymphoid	ALLSIL	4.6
Haematopoietic and lymphoid	AML193	4.4
Haematopoietic and lymphoid	AMO1	4.1
Haematopoietic and lymphoid	BCP1	7.8
Haematopoietic and lymphoid	BDCM	4.2
Haematopoietic and lymphoid	BL41	4.1
Haematopoietic and lymphoid	BL70	4.8
Haematopoietic and lymphoid	BV173	4.8
Haematopoietic and lymphoid	CA46	4.4
Haematopoietic and lymphoid	CI1	4.5
Haematopoietic and lymphoid	CMK115	5.2
Haematopoietic and lymphoid	CMK86	4.7
Haematopoietic and lymphoid	CMK	6.3
Haematopoietic and lymphoid	CMLT1	4.8
Haematopoietic and lymphoid	COLO775	4.2
Haematopoietic and lymphoid	DAUDI	4.3
Haematopoietic and lymphoid	DB	4.3
Haematopoietic and lymphoid	DEL	4
Haematopoietic and lymphoid	DND41	4.2
Haematopoietic and lymphoid	DOHH2	4.2
Haematopoietic and lymphoid	EB1	4.1
Haematopoietic and lymphoid	EB2	4.1
Haematopoietic and lymphoid	EHEB	4
Haematopoietic and lymphoid	EJM	4
Haematopoietic and lymphoid	EM2	4.2
Haematopoietic and lymphoid	EOL1	4
Haematopoietic and lymphoid	F36P	4.5
Haematopoietic and lymphoid	GA10	4.4
Haematopoietic and lymphoid	GDM1	4.3
Haematopoietic and lymphoid	GRANTA519	4.1
Haematopoietic and lymphoid	HDLM2	4.3
Haematopoietic and lymphoid	HDMYZ	4.1
Haematopoietic and lymphoid	HEL9217	5.4
Haematopoietic and lymphoid	HEL	5.4
Haematopoietic and lymphoid	HH	4.5
Haematopoietic and lymphoid	HL60	4.2
Haematopoietic and lymphoid	HPBALL	4.1
Haematopoietic and lymphoid	HS604T	4.3
Haematopoietic and lymphoid	HS611T	4.2
Haematopoietic and lymphoid	HS616T	4.1
Haematopoietic and lymphoid	HS751T	4.2
Haematopoietic and lymphoid	HT	4.1
Haematopoietic and lymphoid	HTK	4.8
Haematopoietic and lymphoid	HUNS1	4.4
Haematopoietic and lymphoid	HUT102	4.2
Haematopoietic and lymphoid	HUT78	4.2
Haematopoietic and lymphoid	JEKO1	4.1
Haematopoietic and lymphoid	JK1	4.7
Haematopoietic and lymphoid	JM1	4.3
Haematopoietic and lymphoid	JURKAT	4
Haematopoietic and lymphoid	JURLMK1	4.2
Haematopoietic and lymphoid	JVM2	4.1
Haematopoietic and lymphoid	JVM3	4
Haematopoietic and lymphoid	K562	4.4
Haematopoietic and lymphoid	KARPAS299	3.9
Haematopoietic and lymphoid	KARPAS422	4.1
Haematopoietic and lymphoid	KARPAS620	4.3
Haematopoietic and lymphoid	KASUMI1	4.4
Haematopoietic and lymphoid	KASUMI2	3.9
Haematopoietic and lymphoid	KASUMI6	4
Haematopoietic and lymphoid	KCL22	4.2
Haematopoietic and lymphoid	KE37	4.2
Haematopoietic and lymphoid	KE97	4.3
Haematopoietic and lymphoid	KG1	4.3
Haematopoietic and lymphoid	KHM1B	4.6
Haematopoietic and lymphoid	KIJK	4
Haematopoietic and lymphoid	KMH2	4.2
Haematopoietic and lymphoid	KMM1	4.4
Haematopoietic and lymphoid	KMS11	4.6
Haematopoietic and lymphoid	KMS12BM	4.6
Haematopoietic and lymphoid	KMS18	4
Haematopoietic and lymphoid	KMS20	4.3
Haematopoietic and lymphoid	KMS21BM	4.2
Haematopoietic and lymphoid	KMS26	4.2
Haematopoietic and lymphoid	KMS27	4.2
Haematopoietic and lymphoid	KMS28BM	3.9
Haematopoietic and lymphoid	KMS34	4.3
Haematopoietic and lymphoid	KO52	4.8
Haematopoietic and lymphoid	KOPN8	4.7
Haematopoietic and lymphoid	KU812	5.5
Haematopoietic and lymphoid	KYO1	4.3
Haematopoietic and lymphoid	L1236	4.2
Haematopoietic and lymphoid	L363	4.1
Haematopoietic and lymphoid	L428	4.4
Haematopoietic and lymphoid	L540	4.3
Haematopoietic and lymphoid	LAMA84	6.3
Haematopoietic and lymphoid	LOUCY	4.6
Haematopoietic and lymphoid	LP1	4
Haematopoietic and lymphoid	M07E	4.9
Haematopoietic and lymphoid	MC116	4.5
Haematopoietic and lymphoid	ME1	4.4
Haematopoietic and lymphoid	MEC1	4.1
Haematopoietic and lymphoid	MEC2	4
Haematopoietic and lymphoid	MEG01	5.3
Haematopoietic and lymphoid	MHHCALL2	4.1
Haematopoietic and lymphoid	MHHCALL3	4.2
Haematopoietic and lymphoid	MHHCALL4	4.1
Haematopoietic and lymphoid	MINO	4.3
Haematopoietic and lymphoid	MJ	4.2
Haematopoietic and lymphoid	MM1S	4.2
Haematopoietic and lymphoid	MOLM13	4.4
Haematopoietic and lymphoid	MOLM16	4.5
Haematopoietic and lymphoid	MOLM6	4
Haematopoietic and lymphoid	MOLP2	4.5
Haematopoietic and lymphoid	MOLP8	4
Haematopoietic and lymphoid	MOLT13	4.2
Haematopoietic and lymphoid	MOLT16	4.2
Haematopoietic and lymphoid	MOLT4	4.1
Haematopoietic and lymphoid	MONOMAC1	4.1
Haematopoietic and lymphoid	MONOMAC6	4.3
Haematopoietic and lymphoid	MOTN1	4.1
Haematopoietic and lymphoid	MUTZ5	4
Haematopoietic and lymphoid	MV411	4.1
Haematopoietic and lymphoid	NALM19	4.2
Haematopoietic and lymphoid	NALM1	4.4
Haematopoietic and lymphoid	NALM6	4.1
Haematopoietic and lymphoid	NAMALWA	4.3
Haematopoietic and lymphoid	NB4	4.4
Haematopoietic and lymphoid	NCIH929	4.6
Haematopoietic and lymphoid	NCO2	4.7
Haematopoietic and lymphoid	NOMO1	4.1
Haematopoietic and lymphoid	NUDHL1	4.4
Haematopoietic and lymphoid	NUDUL1	4.1
Haematopoietic and lymphoid	OCIAML2	4.2
Haematopoietic and lymphoid	OCIAML3	4.1
Haematopoietic and lymphoid	OCIAML5	4
Haematopoietic and lymphoid	OCILY10	4.2
Haematopoietic and lymphoid	OCILY19	4.2
Haematopoietic and lymphoid	OCILY3	4.4
Haematopoietic and lymphoid	OCIM1	4
Haematopoietic and lymphoid	OPM2	4.1
Haematopoietic and lymphoid	P12ICHIKAWA	4.3
Haematopoietic and lymphoid	P31FUJ	4.2
Haematopoietic and lymphoid	P3HR1	4.4
Haematopoietic and lymphoid	PCM6	4.2
Haematopoietic and lymphoid	PEER	4.1
Haematopoietic and lymphoid	PF382	3.9
Haematopoietic and lymphoid	PFEIFFER	4.1
Haematopoietic and lymphoid	PL21	4.2
Haematopoietic and lymphoid	RAJI	4.4
Haematopoietic and lymphoid	RCHACV	3.9
Haematopoietic and lymphoid	REC1	4.1
Haematopoietic and lymphoid	REH	4.3
Haematopoietic and lymphoid	RI1	4.4
Haematopoietic and lymphoid	RL	4.3
Haematopoietic and lymphoid	RPMI8226	4.4
Haematopoietic and lymphoid	RPMI8402	4.1
Haematopoietic and lymphoid	RS411	4.2
Haematopoietic and lymphoid	SEM	4.1
Haematopoietic and lymphoid	SET2	5.3
Haematopoietic and lymphoid	SIGM5	4
Haematopoietic and lymphoid	SKM1	4.1
Haematopoietic and lymphoid	SKMM2	4.2
Haematopoietic and lymphoid	SR786	4.6
Haematopoietic and lymphoid	ST486	4.5
Haematopoietic and lymphoid	SUDHL10	4.4
Haematopoietic and lymphoid	SUDHL1	4.3
Haematopoietic and lymphoid	SUDHL4	4
Haematopoietic and lymphoid	SUDHL5	4.3
Haematopoietic and lymphoid	SUDHL6	4.2
Haematopoietic and lymphoid	SUDHL8	4.6
Haematopoietic and lymphoid	SUPB15	4.4
Haematopoietic and lymphoid	SUPHD1	4.4
Haematopoietic and lymphoid	SUPM2	4.1
Haematopoietic and lymphoid	SUPT11	4
Haematopoietic and lymphoid	SUPT1	4.5
Haematopoietic and lymphoid	TALL1	4.1
Haematopoietic and lymphoid	TF1	4.6
Haematopoietic and lymphoid	THP1	4.1
Haematopoietic and lymphoid	TO175T	4
Haematopoietic and lymphoid	TOLEDO	4.3
Haematopoietic and lymphoid	U266B1	4.5
Haematopoietic and lymphoid	U937	4.1
Haematopoietic and lymphoid	UT7	5.6
Haematopoietic and lymphoid	WSUDLCL2	4.1
Kidney	769P	4.3
Kidney	786O	4
Kidney	A498	4.1
Kidney	A704	4.5
Kidney	ACHN	4.2
Kidney	BFTC909	4
Kidney	CAKI1	4.5
Kidney	CAKI2	4.4
Kidney	CAL54	4
Kidney	KMRC1	4.3
Kidney	KMRC20	4.2
Kidney	KMRC2	4.1
Kidney	KMRC3	4
Kidney	OSRC2	4.1
Kidney	RCC10RGB	4.2
Kidney	SNU1272	4
Kidney	SNU349	4.3
Kidney	TUHR10TKB	3.9
Kidney	TUHR14TKB	4.1
Kidney	TUHR4TKB	3.9
Kidney	VMRCRCW	4.1
Kidney	VMRCRCZ	4
Large intestine	C2BBE1	4.2
Large intestine	CCK81	4.1
Large intestine	CL11	4
Large intestine	CL14	4.2
Large intestine	CL34	3.9
Large intestine	CL40	4
Large intestine	COLO205	4.2
Large intestine	COLO320	4.1
Large intestine	COLO678	4
Large intestine	CW2	3.9
Large intestine	DLD1	4
Large intestine	GP2D	3.9
Large intestine	HCC56	3.9
Large intestine	HCT116	4.4
Large intestine	HCT15	4
Large intestine	HS675T	4
Large intestine	HS698T	3.9
Large intestine	HT115	4
Large intestine	HT29	4.1
Large intestine	HT55	3.9
Large intestine	KM12	4.4
Large intestine	LOVO	4.3
Large intestine	LS1034	4.1
Large intestine	LS123	4.1
Large intestine	LS180	3.9
Large intestine	LS411N	4.3
Large intestine	LS513	4.3
Large intestine	MDST8	4.1
Large intestine	NCIH508	4.1
Large intestine	NCIH716	4.7
Large intestine	NCIH747	4.4
Large intestine	OUMS23	4
Large intestine	RCM1	4.4
Large intestine	RKO	4.2
Large intestine	SKCO1	4
Large intestine	SNU1040	4.1
Large intestine	SNU1197	4
Large intestine	SNU175	4.1
Large intestine	SNU283	4.3
Large intestine	SNU407	4.1
Large intestine	SNU503	3.9
Large intestine	SNU61	4.1
Large intestine	SNU81	4.1
Large intestine	SNUC1	4.1
Large intestine	SNUC2A	5.2
Large intestine	SNUC4	3.9
Large intestine	SNUC5	4
Large intestine	SW1116	4.3
Large intestine	SW1417	4.2
Large intestine	SW1463	4.5
Large intestine	SW403	4.2
Large intestine	SW480	4.1
Large intestine	SW48	4.2
Large intestine	SW620	4
Large intestine	SW837	4.7
Large intestine	SW948	4.1
Large intestine	T84	4.2
Liver	ALEXANDERCELLS	4.2
Liver	C3A	4
Liver	HEP3B217	4.3
Liver	HEPG2	4
Liver	HLE	4.1
Liver	HLF	4.1
Liver	HUH1	3.9
Liver	HUH6	4.3
Liver	HUH7	3.8
Liver	JHH1	4
Liver	JHH2	4
Liver	JHH4	4.1
Liver	JHH5	4.2
Liver	JHH6	4.4
Liver	JHH7	4.4
Liver	LI7	3.8
Liver	PLCPRF5	4.4
Liver	SKHEP1	4.3
Liver	SNU182	4
Liver	SNU387	3.9
Liver	SNU398	4.4
Liver	SNU423	4
Liver	SNU449	4.4
Liver	SNU475	4
Liver	SNU761	4
Liver	SNU878	4.2
Liver	SNU886	3.9
Lung	A549	4.1
Lung	ABC1	4.1
Lung	BEN	4.2
Lung	CAL12T	4.4
Lung	CALU1	4.2
Lung	CALU3	4.2
Lung	CALU6	4.2
Lung	CHAGOK1	4.7
Lung	COLO668	4.1
Lung	COLO699	4
Lung	CORL105	4.1
Lung	CORL23	4.7
Lung	CORL24	4.5
Lung	CORL279	4.4
Lung	CORL311	4.7
Lung	CORL47	6.1
Lung	CORL51	5.7
Lung	CORL88	3.8
Lung	CORL95	4.4
Lung	CPCN	4.5
Lung	DMS114	5.7
Lung	DMS153	4
Lung	DMS273	4.8
Lung	DMS454	4.2
Lung	DMS53	4.1
Lung	DMS79	5.5
Lung	DV90	4.1
Lung	EBC1	4.7
Lung	EPLC272H	4.8
Lung	HARA	4.5
Lung	HCC1171	4
Lung	HCC1195	4.4
Lung	HCC15	4.3
Lung	HCC2279	4.1
Lung	HCC2935	3.9
Lung	HCC33	4.5
Lung	HCC366	4.2
Lung	HCC4006	4.4
Lung	HCC44	4.4
Lung	HCC78	4
Lung	HCC827	4
Lung	HCC95	4.3
Lung	HLC1	4.9
Lung	HLFA	4
Lung	HS229T	4
Lung	HS618T	4.1
Lung	IALM	4.1
Lung	KNS62	4.3
Lung	LC1F	4.4
Lung	LC1SQSF	4.3
Lung	LCLC103H	4
Lung	LCLC97TM1	3.8
Lung	LK2	4.1
Lung	LOUNH91	4.2
Lung	LU65	4
Lung	LU99	4.3
Lung	LUDLU1	4.2
Lung	LXF289	4.2
Lung	MORCPR	4.1
Lung	NCIH1048	4
Lung	NCIH1092	5.4
Lung	NCIH1105	6
Lung	NCIH1155	5.1
Lung	NCIH1184	4.9
Lung	NCIH1299	4.7
Lung	NCIH1339	4.1
Lung	NCIH1341	4.6
Lung	NCIH1355	4.6
Lung	NCIH1373	4.4
Lung	NCIH1385	4.2
Lung	NCIH1395	4.1
Lung	NCIH1435	4.2
Lung	NCIH1436	4.9
Lung	NCIH1437	4.2
Lung	NCIH146	4.6
Lung	NCIH1563	4.1
Lung	NCIH1568	4.2
Lung	NCIH1573	4.3
Lung	NCIH1581	5
Lung	NCIH1618	4.4
Lung	NCIH1623	6.5
Lung	NCIH1648	4.1
Lung	NCIH1650	4.6
Lung	NCIH1651	4.2
Lung	NCIH1666	4.1
Lung	NCIH1693	4.4
Lung	NCIH1694	5.5
Lung	NCIH1703	4.3
Lung	NCIH1734	4.1
Lung	NCIH1755	4.2
Lung	NCIH1781	4
Lung	NCIH1792	4.3
Lung	NCIH1793	4.2
Lung	NCIH1836	4.3
Lung	NCIH1838	4.3
Lung	NCIH1869	4
Lung	NCIH1876	4
Lung	NCIH1915	4
Lung	NCIH1930	5.2
Lung	NCIH1944	4
Lung	NCIH1963	4.9
Lung	NCIH196	4
Lung	NCIH1975	4
Lung	NCIH2009	4.3
Lung	NCIH2023	4.4
Lung	NCIH2029	4.2
Lung	NCIH2030	4.3
Lung	NCIH2066	4.2
Lung	NCIH2081	5
Lung	NCIH2085	4.4
Lung	NCIH2087	4.2
Lung	NCIH209	4.1
Lung	NCIH2106	6
Lung	NCIH2110	4
Lung	NCIH211	4.1
Lung	NCIH2122	4
Lung	NCIH2126	3.9
Lung	NCIH2141	5.3
Lung	NCIH2170	3.9
Lung	NCIH2171	5.1
Lung	NCIH2172	4.5
Lung	NCIH2196	5.5
Lung	NCIH2227	4.7
Lung	NCIH2228	4.4
Lung	NCIH226	5.2
Lung	NCIH2286	5.6
Lung	NCIH2291	4.2
Lung	NCIH2342	4.3
Lung	NCIH2347	4
Lung	NCIH23	4.6
Lung	NCIH2405	4.1
Lung	NCIH2444	4.4
Lung	NCIH292	4.1
Lung	NCIH322	4.4
Lung	NCIH3255	3.9
Lung	NCIH358	4
Lung	NCIH441	4.1
Lung	NCIH446	5.1
Lung	NCIH460	4.4
Lung	NCIH510	4.5
Lung	NCIH520	4.1
Lung	NCIH522	6.2
Lung	NCIH524	4.6
Lung	NCIH526	4.6
Lung	NCIH596	4.3
Lung	NCIH647	4.3
Lung	NCIH650	4
Lung	NCIH661	4.5
Lung	NCIH69	4.6
Lung	NCIH727	4
Lung	NCIH810	4.3
Lung	NCIH82	4.2
Lung	NCIH838	4.6
Lung	NCIH841	6.2
Lung	NCIH854	4.5
Lung	NCIH889	4.3
Lung	PC14	4.3
Lung	RERFLCAD1	4
Lung	RERFLCAD2	4.5
Lung	RERFLCAI	4.1
Lung	RERFLCKJ	4.2
Lung	RERFLCMS	4.2
Lung	RERFLCSQ1	4
Lung	SBC5	5.8
Lung	SCLC21H	6.2
Lung	SHP77	4.7
Lung	SKLU1	4.3
Lung	SKMES1	4.3
Lung	SQ1	4.3
Lung	SW1271	4.3
Lung	SW1573	4
Lung	SW900	4.1
Lung	VMRCLCD	4.3
Lung	VMRCLCP	4.1
Oesophagus	COLO680N	3.8
Oesophagus	ECGI10	4.1
Oesophagus	KYSE140	4.3
Oesophagus	KYSE150	4
Oesophagus	KYSE180	4.4
Oesophagus	KYSE270	4.1
Oesophagus	KYSE30	4.1
Oesophagus	KYSE410	4.3
Oesophagus	KYSE450	4.3
Oesophagus	KYSE510	4.1
Oesophagus	KYSE520	4.1
Oesophagus	KYSE70	4.2
Oesophagus	OE19	4.5
Oesophagus	OE33	4.2
Oesophagus	TE10	4.6
Oesophagus	TE11	4.2
Oesophagus	TE14	3.9
Oesophagus	TE15	4.1
Oesophagus	TE1	4.1
Oesophagus	TE4	4
Oesophagus	TE5	4.2
Oesophagus	TE6	4.1
Oesophagus	TE8	4.9
Oesophagus	TE9	4
Oesophagus	TT	4.2
Ovary	59M	4.4
Ovary	A2780	4
Ovary	CAOV3	4.1
Ovary	CAOV4	4.3
Ovary	COLO704	5.2
Ovary	COV318	5.6
Ovary	COV362	4.4
Ovary	COV434	4.6
Ovary	COV504	4.1
Ovary	COV644	3.8
Ovary	EFO21	4.7
Ovary	EFO27	4.2
Ovary	ES2	4.2
Ovary	FUOV1	4
Ovary	HEYA8	4.1
Ovary	HS571T	4.1
Ovary	IGROV1	4.2
Ovary	JHOC5	4
Ovary	JHOM1	3.9
Ovary	JHOM2B	3.9
Ovary	JHOS2	4.1
Ovary	JHOS4	4
Ovary	KURAMOCHI	4.1
Ovary	MCAS	4.3
Ovary	NIHOVCAR3	4.4
Ovary	OAW28	3.9
Ovary	OAW42	4
Ovary	OC314	5.7
Ovary	OC316	4.4
Ovary	ONCODG1	4
Ovary	OV56	4.4
Ovary	OV7	3.9
Ovary	OV90	4.3
Ovary	OVCAR4	4
Ovary	OVCAR8	4.2
Ovary	OVISE	4
Ovary	OVK18	4.1
Ovary	OVKATE	4.1
Ovary	OVMANA	4.4
Ovary	OVSAHO	4.2
Ovary	OVTOKO	4.4
Ovary	RMGI	4.5
Ovary	RMUGS	4.5
Ovary	SKOV3	4
Ovary	SNU119	4.2
Ovary	SNU840	3.9
Ovary	SNU8	4.1
Ovary	TOV112D	4.9
Ovary	TOV21G	3.9
Ovary	TYKNU	4.2
Pancreas	ASPC1	4.1
Pancreas	BXPC3	4.2
Pancreas	CAPAN1	4.1
Pancreas	CAPAN2	4.2
Pancreas	CFPAC1	4.2
Pancreas	DANG	4
Pancreas	HPAC	4.4
Pancreas	HPAFII	4.2
Pancreas	HS766T	4.1
Pancreas	HUPT3	4.2
Pancreas	HUPT4	4.2
Pancreas	KCIMOH1	3.8
Pancreas	KLM1	4.1
Pancreas	KP2	4
Pancreas	KP3	4.3
Pancreas	KP4	5.1
Pancreas	L33	4.1
Pancreas	MIAPACA2	6.9
Pancreas	PANC0203	4.2
Pancreas	PANC0213	4.1
Pancreas	PANC0327	4.1
Pancreas	PANC0403	4.3
Pancreas	PANC0504	4.1
Pancreas	PANC0813	4.1
Pancreas	PANC1005	4
Pancreas	PANC1	6.8
Pancreas	PATU8902	4
Pancreas	PATU8988S	4.1
Pancreas	PATU8988T	3.9
Pancreas	PK1	4.1
Pancreas	PK45H	4.1
Pancreas	PK59	4.3
Pancreas	PL45	4.1
Pancreas	PSN1	4.3
Pancreas	QGP1	4.2
Pancreas	SNU213	4.7
Pancreas	SNU324	3.9
Pancreas	SNU410	5.2
Pancreas	SU8686	4
Pancreas	SUIT2	4.2
Pancreas	SW1990	4.5
Pancreas	T3M4	4.3
Pancreas	TCCPAN2	4.2
Pancreas	YAPC	4.1
Pleura	ACCMESO1	4.5
Pleura	DM3	4
Pleura	ISTMES1	5.2
Pleura	ISTMES2	5.8
Pleura	JL1	4.7
Pleura	MPP89	4.1
Pleura	MSTO211H	4.2
Pleura	NCIH2052	4.2
Pleura	NCIH2452	4.4
Pleura	NCIH28	4.5
Prostate	22RV1	3.9
Prostate	DU145	4.2
Prostate	LNCAPCLONEFGC	4.2
Prostate	MDAPCA2B	4.2
Prostate	NCIH660	5.2
Prostate	PC3	4.2
Prostate	VCAP	4.3
Salivary gland	A253	4.2
Salivary gland	YD15	4.1
Skin	A101D	4.3
Skin	A2058	3.9
Skin	A375	3.9
Skin	C32	4
Skin	CHL1	4.5
Skin	CJM	4
Skin	COLO679	4
Skin	COLO741	4.1
Skin	COLO783	3.9
Skin	COLO792	4.1
Skin	COLO800	4
Skin	COLO818	4.3
Skin	COLO829	4
Skin	COLO849	4.1
Skin	G361	4
Skin	GRM	4
Skin	HMCB	4.4
Skin	HS294T	4.1
Skin	HS600T	4.1
Skin	HS688AT	4
Skin	HS695T	4.3
Skin	HS839T	4.3
Skin	HS852T	4
Skin	HS895T	4.3
Skin	HS934T	3.9
Skin	HS936T	4.2
Skin	HS939T	3.8
Skin	HS940T	4.1
Skin	HS944T	4
Skin	HT144	4.1
Skin	IGR1	4
Skin	IGR37	4
Skin	IGR39	4.1
Skin	IPC298	3.9
Skin	K029AX	4
Skin	LOXIMVI	4
Skin	MALME3M	4.1
Skin	MDAMB435S	4.4
Skin	MELHO	4.2
Skin	MELJUSO	4.1
Skin	MEWO	4.1
Skin	RPMI7951	3.9
Skin	RVH421	4.2
Skin	SH4	3.9
Skin	SKMEL1	4.2
Skin	SKMEL24	4
Skin	SKMEL28	4.1
Skin	SKMEL2	3.9
Skin	SKMEL30	4
Skin	SKMEL31	4
Skin	SKMEL3	3.9
Skin	SKMEL5	4.1
Skin	UACC257	4.1
Skin	UACC62	4.3
Skin	WM115	4
Skin	WM1799	3.9
Skin	WM2664	3.8
Skin	WM793	4.1
Skin	WM88	4
Skin	WM983B	4
Small intestine	HUTU80	5.3
Soft tissue	A204	4.2
Soft tissue	G401	5.6
Soft tissue	G402	5.2
Soft tissue	GCT	4.2
Soft tissue	HS729	4
Soft tissue	HT1080	4
Soft tissue	KYM1	4.7
Soft tissue	MESSA	4.4
Soft tissue	RD	4
Soft tissue	RH30	3.9
Soft tissue	RH41	4.4
Soft tissue	RKN	4.2
Soft tissue	S117	4.2
Soft tissue	SJRH30	4
Soft tissue	SKLMS1	4
Soft tissue	SKUT1	4.3
Soft tissue	TE125T	4
Soft tissue	TE159T	4.2
Soft tissue	TE441T	5.8
Soft tissue	TE617T	5.9
Stomach	2313287	4
Stomach	AGS	4.2
Stomach	AZ521	4.8
Stomach	ECC10	4.4
Stomach	ECC12	3.6
Stomach	FU97	4.1
Stomach	GCIY	4.1
Stomach	GSS	4.3
Stomach	GSU	4
Stomach	HGC27	4.3
Stomach	HS746T	4
Stomach	HUG1N	4.2
Stomach	IM95	4.2
Stomach	KATOIII	4.1
Stomach	KE39	4.2
Stomach	LMSU	3.7
Stomach	MKN1	4.1
Stomach	MKN45	4.2
Stomach	MKN74	4.6
Stomach	MKN7	4.2
Stomach	NCCSTCK140	4.1
Stomach	NCIN87	4
Stomach	NUGC2	4.1
Stomach	NUGC3	4
Stomach	NUGC4	4.5
Stomach	OCUM1	4.2
Stomach	RERFGC1B	4.3
Stomach	SH10TC	4.3
Stomach	SNU16	4.3
Stomach	SNU1	4.5
Stomach	SNU216	4
Stomach	SNU520	3.9
Stomach	SNU5	4.3
Stomach	SNU601	3.9
Stomach	SNU620	4
Stomach	SNU668	4.1
Stomach	SNU719	4.2
Stomach	TGBC11TKB	4
Thyroid	8305C	3.9
Thyroid	8505C	4.1
Thyroid	BCPAP	4.1
Thyroid	BHT101	3.8
Thyroid	CAL62	3.8
Thyroid	CGTHW1	4
Thyroid	FTC133	4.1
Thyroid	FTC238	4.1
Thyroid	ML1	4
Thyroid	SW579	4
Thyroid	TT2609C02	3.9
Thyroid	TT	4.1
Upper aerodigestive tract	BHY	3.9
Upper aerodigestive tract	BICR16	4.3
Upper aerodigestive tract	BICR18	4.3
Upper aerodigestive tract	BICR22	4.2
Upper aerodigestive tract	BICR31	4.2
Upper aerodigestive tract	BICR56	4.4
Upper aerodigestive tract	BICR6	4.5
Upper aerodigestive tract	CAL27	4.2
Upper aerodigestive tract	CAL33	4
Upper aerodigestive tract	DETROIT562	4.3
Upper aerodigestive tract	FADU	4.2
Upper aerodigestive tract	HS840T	4.2
Upper aerodigestive tract	HSC2	4.5
Upper aerodigestive tract	HSC3	4.3
Upper aerodigestive tract	HSC4	4.1
Upper aerodigestive tract	PECAPJ15	4.1
Upper aerodigestive tract	PECAPJ34CLONEC12	4.2
Upper aerodigestive tract	PECAPJ41CLONED2	4.4
Upper aerodigestive tract	PECAPJ49	4.1
Upper aerodigestive tract	SCC15	4
Upper aerodigestive tract	SCC25	4.3
Upper aerodigestive tract	SCC4	4.2
Upper aerodigestive tract	SCC9	4.2
Upper aerodigestive tract	SNU1076	4
Upper aerodigestive tract	SNU1214	4.1
Upper aerodigestive tract	SNU46	4.6
Upper aerodigestive tract	SNU899	4
Upper aerodigestive tract	YD10B	4.2
Upper aerodigestive tract	YD38	4.3
Upper aerodigestive tract	YD8	3.8
Urinary tract	5637	4.1
Urinary tract	639V	4.1
Urinary tract	647V	4
Urinary tract	BC3C	4.1
Urinary tract	BFTC905	4
Urinary tract	CAL29	4.1
Urinary tract	HS172T	3.9
Urinary tract	HT1197	4.2
Urinary tract	HT1376	4
Urinary tract	J82	4.1
Urinary tract	JMSU1	4.2
Urinary tract	KMBC2	4.1
Urinary tract	KU1919	5
Urinary tract	RT11284	3.9
Urinary tract	RT112	4.2
Urinary tract	RT4	4.2
Urinary tract	SCABER	4.3
Urinary tract	SW1710	3.9
Urinary tract	SW780	4.2
Urinary tract	T24	4.1
Urinary tract	TCCSUP	4.1
Urinary tract	UMUC1	4.2
Urinary tract	UMUC3	4.7
Urinary tract	VMCUB1	4.1

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	0
Adrenal gland	5.8
Appendix	0.3
Bone marrow	0
Breast	0
Cerebral cortex	42.2
Cervix, uterine	0.2
Colon	0.2
Duodenum	0.2
Endometrium	0.1
Epididymis	0.1
Esophagus	0.3
Fallopian tube	0.2
Gallbladder	0.2
Heart muscle	0.2
Kidney	0.2
Liver	0
Lung	0.1
Lymph node	0
Ovary	0
Pancreas	0
Parathyroid gland	0.2
Placenta	0
Prostate	0.9
Rectum	0.2
Salivary gland	0
Seminal vesicle	3.2
Skeletal muscle	0
Skin	0
Small intestine	0.3
Smooth muscle	0.2
Spleen	0.1
Stomach	0.1
Testis	6.1
Thyroid gland	0
Tonsil	0
Urinary bladder	0

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28400267	Aberrant Expression	Non-Small Cell Lung Cancer	CHD5 was down-regulated in 17 (39.5%) and up-regulated in 24 (55.8%) of tumor specimens.
27895765	Underexpression (hypermethylation)	Breast Carcinoma	CHD5 expression was significantly suppressed in breast cancer tissues compared with normal breast tissues when analyzed by RT-PCR. Furthermore, DNA methylation of CHD5 was more prevalent in breast tumors than in normal tissues. Thus, downregulation of CHD5, mediated by abnormal methylation, may contribute to the development and progression of breast cancer.
26943038	Underexpression (hypermethylation); Loss of Expression (hypermethylation)	Renal Cell Carcinoma	We found that CHD5 was broadly expressed in most normal genitourinary tissues including kidney, but frequently silenced or downregulated by promoter CpG methylation in 78% of RCC cell lines and 44% (24/55) of primary tumors.
26753653	Underexpression (hypermethylation)	Adenoma; Colorectal Carcinoma	Results revealed that the expression rate of CHD5 methylation in 40 normal mucosal tissues, para-carcinoma tissues, adenoma tissues and CRC tissues was 12.5% (5/40), 22.5% (9/40), 47.5% (19/40) and 72.5% (33/40), respectively. The mRNA expression of CHD5 in the above tissues was 0.225±0.276, 0.169±0.231, 0.147±0.159 and 0.013±0.011 and the protein expression of CHD5 was 0.438±0.205, 0.398±0.180, 0.156±0.1 and 0.024±0.311, respectively. Methylation rate of CHD5 was 87% (20/23) in 23 cases of CHD5 protein loss expression and 52.9% (9/17) in 17 cases of CHD5 protein expression. Results of chi-squared test indicated that there was a significant difference in methylation rate (P less than 0.05), that is, the methylation rate of negatively expressed CHD5 protein was obviously higher than positively expressed protein.
26625313	altered expression	Bladder Carcinoma	We uncovered that MLL, EP400, PRDM2, ANK3 and CHD5 exclusively altered in recurrent BCs.
26517514	Loss of expression (hypermethylation)	Hepatocellular Carcinoma	In the present study, we demonstrated that reduced levels of CHD5 in hepatocellular carcinoma (HCC) tissues were significantly associated with metastasis and poor prognosis. Gain-of-function assays revealed that CHD5 suppressed motility and invasion of HCC cells. Subsequent investigations showed that CHD5 was epigenetically silenced by polycomb repressive complex 2 (PRC2)-mediated the trimethylation of histone H3 at lysine 27 (H3K27me3) in HCC cells.
26245651	Underexpression	Hepatocellular Carcinoma	CHD5 was downregulated in HCC tissues and cell lines and the expression level of CHD5 was inversely correlated with the expression of miR-454 in HCC tissues.
25247294	Loss of Expression	Neuroblastoma	Loss of the chromatin remodeling ATPase CHD5 has been linked to the progression of neuroblastoma tumors, yet the underlying mechanisms behind the tumor suppressor role of CHD5 are unknown.
24529164	Underexpression (hypermethylation)	Hepatocellular Carcinoma	CHD5 expression was sinificantly down-regulated in HCC cell lines and tissues examined, and the -841 to -470 region of CHD5 promoter was hypermethylated in these samples.
24454811	Underexpression (hypermethylation)	Leukemia	In this study, quantitative reverse-transcriptase polymerase chain reaction and western blotting analyses revealed that CHD5 was down-regulated in human leukemia cell lines and samples. Thus, CHD5 expression was inversely correlated with promoter DNA methylation in these samples.
24276239	Underexpression; Loss of Expression	Pancreatic Carcinoma	CHD5 depletion and low CHD5 expression in human pancreatic cancer cells lead to increased H2AX-Ser139 and CHK2-Thr68 phosphorylation and accumulation into nuclear foci.
24243398	Loss of Expression (hypermethylation)	Adenoma	In most adenoma samples, CHD5 expression was not detected in contrast to normal tissues. In RKO cells, CHD5 silencing was associated with DNA methylation and repressive histone modifications.
23707602	Underexpression	Glioma	Genetic and protein expression of CHD5 were downregulated in glioma tissues compared to corresponding non-neoplastic brain tissues (both p<0.001).
22855185	Underexpression	Gallbladder Carcinoma	The expression levels of CHD5 mRNA and protein in PGC tissues were both significantly lower than those in the normal epithelium of the gallbladder (mRNA: P = 0.006; protein: P = 0.01).
22569290	Mutation; Underexpression (hypermethylation)	Breast Carcinoma	Although only one mutation was detected, CHD5 mRNA expression was significantly reduced, accompanied by frequent genomic deletion and promoter methylation, in breast cancer.
22294723	Mutation; Loss of Expression (hypermethylation); Deletion; Underexpression (hypermethylation)	Neuroblastoma	We conclude that (i) somatically acquired CHD5 mutations are rare in primary NBs, so inactivation probably occurs by deletion and epigenetic silencing; (ii) CHD5 expression and promoter methylation are associated with MYCN amplification, suggesting a possible interaction between these 2 genes; and (iii) high CHD5 expression is strongly correlated with favorable clinical/biological features and outcome.
22186629	Underexpression (hypermethylation); Loss of Expression (hypermethylation)	Lung Carcinoma	CHD5 expression ranged from low to absent in the lung cancer cell lines and tissues examined; the CHD5 promoter was hyperethylated in these samples.
21860208	Underexpression	Ovarian Carcinoma	CHD5 expression was downregulated by at least twofold in 32 of 72 (41%) invasive epithelial ovarian carcinomas when compared to 12 controls in Hong Kong Chinese women.
21636313	Underexpression	Laryngeal Squamous Cell Carcinoma	Our results revealed that the mRNA and protein expression levels of CHD5 in LSCC tissues were significantly lower than those in clear surgical margin tissues (p<0.05), and there is a significant correlation between the mRNA and protein expression levels of CHD5 (p<0.01).
20950435	altered expression	Neuroblastoma	An immunohistochemical analysis of 90 primary NTs highlighted a strong association of CHD5 expression with favorable prognostic variables (age at diagnosis <12 months, low clinical stage, and favorable histology; P < 0.001 for all), overall survival (OS) (P < 0.001) and event-free survival (EFS) (P < 0.001).
19840376	Underexpression (hypermethylation)	Gastric Carcinoma	CHD5 expression was down-regulated in all of gastric cancer cell lines used (100%, 7/7) and significantly restored after pharmacological demethylation.
18698156	Loss of Expression (hypermethylation)	Glioma; Breast Carcinoma	For all CHDs, CpG island hypermethylation was only observed at the CHD5 promoter in human cancer cell lines and primary tumors, particularly gliomas and colon and breast carcinomas. RT-qPCR analyses correlated CHD5 Loss of expression with hypermethylation of the promoter, and restoration of CHD5 mRNA levels upon treatment with a DNA demethylating agent.
18577749	Underexpression (hypermethylation); Loss of Expression (hypermethylation); copy number loss	Neuroblastoma	CHD5 expression was very low or absent in neuroblastoma cell lines. The CHD5 promoter was highly methylated in NLF and IMR5 lines, and CHD5 expression increased after treatment with 5-aza-2-deoxycytidine. CHD5 is the strongest candidate tumor suppressor gene that is deleted from 1p36.31 in neuroblastomas, and inactivation of the second allele may occur by an epigenetic mechanism.
12592387	Underexpression; Loss of Expression	Neuroblastoma	We examined a panel of neuroblastoma cell lines for CHD5 expression, which was consistently low or undetectable in all these lines.

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.158	0.00144	19.6	58.7	21.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.095	0.00178	39.7	52.9	7.3	Loss
CESC	Cervical and endocervical cancers	292	0.008	0.886	13	59.6	27.4	Neutral
COAD	Colon adenocarcinoma	449	-0.02	0.671	33.2	63.9	2.9	Neutral
ESCA	Esophageal carcinoma	183	0.326	6.68e-06	36.6	44.3	19.1	Loss
GBM	Glioblastoma multiforme	147	-0.058	0.488	22.4	61.2	16.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	-0.056	0.204	19.4	79	1.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.027	0.645	19.1	80.6	0.3	Neutral
LAML	Acute Myeloid Leukemia	166	0.115	0.142	1.2	96.4	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	-0.043	0.335	41.3	56.5	2.1	Loss
LUSC	Lung squamous cell carcinoma	498	0.186	2.96e-05	43.4	44	12.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.137	0.0686	28.2	64.4	7.3	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.076	0.335	63.6	35.8	0.6	Loss
PRAD	Prostate adenocarcinoma	491	0.061	0.175	10.4	88.4	1.2	Neutral
READ	Rectum adenocarcinoma	164	-0.007	0.926	42.7	55.5	1.8	Loss
SARC	Sarcoma	255	-0.187	0.00269	23.9	47.5	28.6	Neutral
STAD	Stomach adenocarcinoma	413	0.132	0.00711	23.7	63.4	12.8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.304	0.000153	22.7	60.7	16.7	Neutral
THCA	Thyroid carcinoma	497	0.104	0.0206	1	98.6	0.4	Neutral
THYM	Thymoma	119	0.156	0.0893	6.7	92.4	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	-0.028	0.516	13	77.7	9.3	Neutral

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.103	0.0346	17	408	-0.026	0.842	NS/NA
BRCA	Breast invasive carcinoma	-0.106	0.00169	83	785	0	0.0523	NS/NA
CESC	Cervical and endocervical cancers	-0.169	0.00288	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.057	0.312	19	297	0.002	5.22e-16	NS/NA
ESCA	Esophageal carcinoma	-0.057	0.428	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.376	0.00216	1	64	NA	NA	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.223	3.13e-05	24	319	0.014	4.49e-14	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.397	1.52e-12	23	275	-0.002	3.73e-05	NS/NA
LAML	Acute Myeloid Leukemia	-0.036	0.642	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.038	0.376	0	530	NA	NA	NS/NA
LUSC	Lung squamous cell carcinoma	-0.076	0.139	8	370	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.071	0.337	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.195	0.00767	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.382	0	35	498	0.171	7.79e-12	NS/NA
READ	Rectum adenocarcinoma	-0.146	0.146	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.388	9.57e-11	0	263	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.262	3.39e-07	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.288	0.000277	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.267	1.59e-10	50	509	-0.012	0.434	NS/NA
THYM	Thymoma	-0.202	0.0259	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.248	6.55e-08	34	431	-0.012	0.0725	NS/NA

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	0	Not detected
Bone marrow	0	Not detected
Breast	0	Not detected
Bronchus	0	Not detected
Caudate	0	Not detected
Cerebellum	3	High
Cerebral cortex	0	Not detected
Cervix, uterine	0	Not detected
Colon	0	Not detected
Duodenum	0	Not detected
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	0	Not detected
Fallopian tube	0	Not detected
Gallbladder	0	Not detected
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	0	Not detected
Liver	0	Not detected
Lung	0	Not detected
Lymph node	0	Not detected
Nasopharynx	0	Not detected
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	0	Not detected
Prostate	0	Not detected
Rectum	0	Not detected
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	0	Not detected
Small intestine	0	Not detected
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	0	Not detected
Testis	0	Not detected
Thyroid gland	0	Not detected
Tonsil	0	Not detected
Urinary bladder	0	Not detected
Vagina	0	Not detected

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.582	NS	24476821
BRCA	Breast invasive carcinoma	521	4.02e-06	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00203	Significant	22810696
GBM	Glioblastoma multiforme	157	0.167	NS	26824661
KIRP	Kidney renal papillary cell carcinoma	161	0.048	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.000587	Significant	26824661
LUSC	Lung squamous cell carcinoma	178	0.000416	Significant	22960745
PRAD	Prostate adenocarcinoma	333	0.00201	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0349	Significant	22810696
STAD	Stomach adenocarcinoma	277	4.9e-07	Significant	25079317
THCA	Thyroid carcinoma	391	1.58e-07	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	9.84e-05	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.189	0.443	NS
BRCA	Breast invasive carcinoma	1079	1.703	0.0225	Shorter
CESC	Cervical and endocervical cancers	291	1.139	0.694	NS
COAD	Colon adenocarcinoma	439	2.319	0.007	Shorter
ESCA	Esophageal carcinoma	184	1.118	0.718	NS
GBM	Glioblastoma multiforme	158	1.384	0.206	NS
KIRC	Kidney renal clear cell carcinoma	531	1.636	0.0246	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.484	0.105	NS
LAML	Acute Myeloid Leukemia	149	0.933	0.812	NS
LGG	Brain Lower Grade Glioma	511	0.504	0.00739	Longer
LUSC	Lung squamous cell carcinoma	494	1.23	0.284	NS
PAAD	Pancreatic adenocarcinoma	177	0.493	0.0248	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	638003580.753	0.301	NS
PRAD	Prostate adenocarcinoma	497	1.587	0.611	NS
READ	Rectum adenocarcinoma	159	2.269	0.183	NS
SARC	Sarcoma	259	1.161	0.622	NS
STAD	Stomach adenocarcinoma	388	1.447	0.119	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.292	NS
THCA	Thyroid carcinoma	500	0.648	0.567	NS
THYM	Thymoma	119	0.285	0.254	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	2.639	0.00127	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.011	0.825	NS
BRCA	Breast invasive carcinoma	1071	0.045	0.145	NS
CESC	Cervical and endocervical cancers	167	0.099	0.203	NS
COAD	Colon adenocarcinoma	445	0.163	0.000564	Higher
ESCA	Esophageal carcinoma	162	0.114	0.149	NS
KIRC	Kidney renal clear cell carcinoma	531	0.003	0.942	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.138	0.0265	Lower
LUSC	Lung squamous cell carcinoma	497	0.048	0.29	NS
PAAD	Pancreatic adenocarcinoma	176	-0.253	0.000701	Lower
READ	Rectum adenocarcinoma	156	0.079	0.327	NS
STAD	Stomach adenocarcinoma	392	0.127	0.0118	Higher
TGCT	Testicular Germ Cell Tumors	81	0.176	0.117	NS
THCA	Thyroid carcinoma	499	0.01	0.818	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.15	0.000736	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.066	0.278	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.011	0.799	NS
LGG	Brain Lower Grade Glioma	514	-0.194	9.38e-06	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.066	0.384	NS
STAD	Stomach adenocarcinoma	406	0.037	0.458	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.147	0.000673	Higher

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for CHD5.

Summary
Symbol	CHD5
Name	chromodomain helicase DNA binding protein 5
Aliases	CHD-5; ATP-dependent helicase CHD5; Chromodomain-helicase-DNA-binding protein 5
Location	1p36.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26943038	Renal Cell Carcinoma	downstream	MYC; MDM2; STAT; CCND1; YAP1	Negative regulation	Moreover, we found that CHD5, as a chromatin remodeling factor, suppressed the expression of multiple targets including oncogenes (MYC, MDM2, STAT3, CCND1, YAP1), epigenetic master genes (Bmi-1, EZH2, JMJD2C), as well as epithelial-mesenchymal transition and stem cell markers (SNAI1, FN1, OCT4).
26517514	Hepatocellular Carcinoma	partner	EZH2	mutual exclusive	Chromatin immunoprecipitation and luciferase reporter assays also showed that CHD5 and EZH2 bind to each other's promoters and inhibit transcription.
26245651	Hepatocellular Carcinoma	partner	miR-454	Negative correlation	CHD5 was downregulated in HCC tissues and cell lines and the expression level of CHD5 was inversely correlated with the expression of miR-454 in HCC tissues.
25247294	Neuroblastoma	partner	NuRD; CHD4/NuRD	Binding; mutually exclusive	In this study, we purified the human CHD5 complex and found that CHD5 is a component of the full NuRD transcriptional repressor complex, which also contains methyl-CpG binding proteins and histone deacetylase. The CHD5/NuRD complex appears mutually exclusive with the related CHD4/NuRD complex as overexpression of CHD5 results in loss of the CHD4 protein in cells.
25247294	Neuroblastoma	downstream	WEE1	Negative regulation	Reintroduction of CHD5 into neuroblastoma cells represses WEE1 expression, demonstrating that CHD5 can function as a repressor in cells.
24419087	Neuroblastoma; Breast Carcinoma; Colon Carcinoma; Lung Carcinoma; Ovarian Carcinomaa; Prostate Carcinoma	partner	NuRD	Binding	CHD5 (chromodomain-helicase-DNA-binding-5) is the fifth member of a family of chromatin remodeling proteins, and it probably functions by forming a nucleosome remodeling and deacetylation (NuRD) complex that regulates transcription of particular genes.
24276239	Pancreatic Carcinoma	downstream	H2AX-Ser139 phosphorylation; CHK2-Thr68	Positive regulation	CHD5 depletion and low CHD5 expression in human pancreatic cancer cells lead to increased H2AX-Ser139 and CHK2-Thr68 phosphorylation and accumulation into nuclear foci.
22569290	Breast Carcinoma	downstream	vimentin; N-cadherin; ZEB1	Negative regulation	Consistent with the inhibition of invasion, CHD5 down-regulated mesenchymal markers vimentin, N-cadherin and ZEB1 in breast cancer cells.