CR2Cancer

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF07533 BRK domain
PF00385 Chromo (CHRromatin Organisation MOdifier) domain
PF00271 Helicase conserved C-terminal domain
PF00176 SNF2 family N-terminal domain

Function

Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	#	#	5201778

> Gene Ontology [ TOP ]
Biological Process	GO:0001501 skeletal system development GO:0001654 eye development GO:0001701 in utero embryonic development GO:0001974 blood vessel remodeling GO:0002521 leukocyte differentiation GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0003007 heart morphogenesis GO:0003013 circulatory system process GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003215 cardiac right ventricle morphogenesis GO:0003221 right ventricular cardiac muscle tissue morphogenesis GO:0003222 ventricular trabecula myocardium morphogenesis GO:0003223 ventricular compact myocardium morphogenesis GO:0003226 right ventricular compact myocardium morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003231 cardiac ventricle development GO:0003279 cardiac septum development GO:0006338 chromatin remodeling GO:0006364 rRNA processing GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007159 leukocyte cell-cell adhesion GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007423 sensory organ development GO:0007507 heart development GO:0007512 adult heart development GO:0007517 muscle organ development GO:0007548 sex differentiation GO:0007605 sensory perception of sound GO:0007626 locomotory behavior GO:0007628 adult walking behavior GO:0007635 chemosensory behavior GO:0008015 blood circulation GO:0008344 adult locomotory behavior GO:0009914 hormone transport GO:0010522 regulation of calcium ion transport into cytosol GO:0010817 regulation of hormone levels GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010959 regulation of metal ion transport GO:0014706 striated muscle tissue development GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0015833 peptide transport GO:0016072 rRNA metabolic process GO:0021537 telencephalon development GO:0021545 cranial nerve development GO:0021553 olfactory nerve development GO:0021675 nerve development GO:0021772 olfactory bulb development GO:0021988 olfactory lobe development GO:0022613 ribonucleoprotein complex biogenesis GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0030252 growth hormone secretion GO:0030326 embryonic limb morphogenesis GO:0030534 adult behavior GO:0030540 female genitalia development GO:0030900 forebrain development GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0034470 ncRNA processing GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035116 embryonic hindlimb morphogenesis GO:0035137 hindlimb morphogenesis GO:0035239 tube morphogenesis GO:0035264 multicellular organism growth GO:0035904 aorta development GO:0035909 aorta morphogenesis GO:0036302 atrioventricular canal development GO:0040014 regulation of multicellular organism growth GO:0040018 positive regulation of multicellular organism growth GO:0042048 olfactory behavior GO:0042110 T cell activation GO:0042254 ribosome biogenesis GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042886 amide transport GO:0043010 camera-type eye development GO:0043583 ear development GO:0043584 nose development GO:0044708 single-organism behavior GO:0045927 positive regulation of growth GO:0046660 female sex differentiation GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0048514 blood vessel morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048644 muscle organ morphogenesis GO:0048736 appendage development GO:0048738 cardiac muscle tissue development GO:0048752 semicircular canal morphogenesis GO:0048771 tissue remodeling GO:0048806 genitalia development GO:0048839 inner ear development GO:0048844 artery morphogenesis GO:0050890 cognition GO:0050954 sensory perception of mechanical stimulus GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051279 regulation of release of sequestered calcium ion into cytosol GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051480 regulation of cytosolic calcium ion concentration GO:0051924 regulation of calcium ion transport GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0055074 calcium ion homeostasis GO:0060021 palate development GO:0060041 retina development in camera-type eye GO:0060123 regulation of growth hormone secretion GO:0060173 limb development GO:0060324 face development GO:0060384 innervation GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0060411 cardiac septum morphogenesis GO:0060415 muscle tissue morphogenesis GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060840 artery development GO:0060872 semicircular canal development GO:0061383 trabecula morphogenesis GO:0061384 heart trabecula morphogenesis GO:0061458 reproductive system development GO:0070296 sarcoplasmic reticulum calcium ion transport GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0071593 lymphocyte aggregation GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090279 regulation of calcium ion import GO:0090596 sensory organ morphogenesis GO:0090659 walking behavior GO:0097553 calcium ion transmembrane import into cytosol GO:1902656 calcium ion import into cytosol GO:1903169 regulation of calcium ion transmembrane transport GO:1903514 calcium ion transport from endoplasmic reticulum to cytosol GO:1904062 regulation of cation transmembrane transport GO:2000021 regulation of ion homeostasis
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0004386 helicase activity GO:1990841 promoter-specific chromatin binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1457703	c.2959C>T	p.R987*	Substitution - Nonsense	Large_intestine
COSM3367386	c.8450A>G	p.N2817S	Substitution - Missense	Kidney
COSM1457755	c.8956delG	p.D2988fs*3	Deletion - Frameshift	Large_intestine
COSM4672091	c.7544G>T	p.R2515M	Substitution - Missense	Large_intestine
COSM1457755	c.8956delG	p.D2988fs*3	Deletion - Frameshift	Large_intestine
COSM3900853	c.752A>G	p.H251R	Substitution - Missense	Stomach
COSM1100782	c.935G>A	p.R312Q	Substitution - Missense	Endometrium
COSM1457738	c.6693T>C	p.S2231S	Substitution - coding silent	Large_intestine
COSM5071648	c.8088T>C	p.P2696P	Substitution - coding silent	Large_intestine
COSM3900855	c.860C>T	p.P287L	Substitution - Missense	Stomach
COSM3900874	c.5816G>A	p.R1939Q	Substitution - Missense	Stomach
COSM159985	c.7941G>A	p.V2647V	Substitution - coding silent	Breast
COSM3650076	c.3978C>T	p.L1326L	Substitution - coding silent	Skin
COSM1201004	c.8176G>T	p.A2726S	Substitution - Missense	Large_intestine
COSM273707	c.4478G>A	p.R1493H	Substitution - Missense	Large_intestine
COSM255886	c.2739_2740delTG	p.Y913fs*1	Deletion - Frameshift	Central_nervous_system
COSM1100898	c.7720C>A	p.L2574I	Substitution - Missense	Endometrium
COSM751041	c.6712G>T	p.E2238*	Substitution - Nonsense	Lung
COSM2720089	c.5049C>T	p.S1683S	Substitution - coding silent	Skin
COSM4672090	c.7330T>G	p.L2444V	Substitution - Missense	Large_intestine
COSM227292	c.5320C>T	p.P1774S	Substitution - Missense	Skin
COSM4439394	c.1007A>G	p.N336S	Substitution - Missense	Oesophagus
COSM3650073	c.3454G>A	p.E1152K	Substitution - Missense	Skin
COSM1489362	c.7731G>C	p.G2577G	Substitution - coding silent	Breast
COSM4619629	c.5441C>T	p.A1814V	Substitution - Missense	Large_intestine
COSM5976889	c.549T>C	p.P183P	Substitution - coding silent	Upper_aerodigestive_tract
COSM6013176	c.2810C>T	p.S937F	Substitution - Missense	Skin
COSM3650077	c.4070C>T	p.S1357F	Substitution - Missense	Skin
COSM751047	c.5773A>G	p.K1925E	Substitution - Missense	Lung
COSM4672087	c.4886G>A	p.R1629H	Substitution - Missense	Large_intestine
COSM2720022	c.2830C>T	p.R944C	Substitution - Missense	Large_intestine
COSM5492385	c.4G>A	p.A2T	Substitution - Missense	Biliary_tract
COSM1314138	c.4072G>A	p.D1358N	Substitution - Missense	Urinary_tract
COSM5699453	c.2871G>T	p.E957D	Substitution - Missense	Soft_tissue
COSM4827146	c.5977G>C	p.D1993H	Substitution - Missense	Cervix
COSM751055	c.4521C>T	p.S1507S	Substitution - coding silent	Lung
COSM1201010	c.4446C>A	p.F1482L	Substitution - Missense	Large_intestine
COSM1457753	c.8803G>A	p.E2935K	Substitution - Missense	Large_intestine
COSM422091	c.3841C>T	p.Q1281*	Substitution - Nonsense	Urinary_tract
COSM1457709	c.3763C>T	p.P1255S	Substitution - Missense	Large_intestine
COSM4672085	c.2819C>T	p.P940L	Substitution - Missense	Prostate
COSM268043	c.6122C>T	p.S2041F	Substitution - Missense	Large_intestine
COSM5422344	c.8387T>A	p.L2796Q	Substitution - Missense	Prostate
COSM3900878	c.6630G>T	p.E2210D	Substitution - Missense	Stomach
COSM1457694	c.1808A>G	p.N603S	Substitution - Missense	Large_intestine
COSM486573	c.7395T>C	p.F2465F	Substitution - coding silent	Kidney
COSM4672083	c.1376delG	p.R459fs*4	Deletion - Frameshift	Large_intestine
COSM4909501	c.316C>T	p.H106Y	Substitution - Missense	Liver
COSM5907469	c.8965G>A	p.E2989K	Substitution - Missense	Skin
COSM751069	c.2138A>C	p.K713T	Substitution - Missense	Lung
COSM213583	c.4853G>T	p.W1618L	Substitution - Missense	Breast
COSM287238	c.3566G>A	p.R1189H	Substitution - Missense	Large_intestine
COSM1100904	c.8175C>T	p.I2725I	Substitution - coding silent	Large_intestine
COSM5922669	c.6937G>A	p.D2313N	Substitution - Missense	Skin
COSM1100788	c.2329G>A	p.A777T	Substitution - Missense	Endometrium
COSM3382280	c.5339A>T	p.E1780V	Substitution - Missense	Pancreas
COSM1496873	c.6873C>A	p.D2291E	Substitution - Missense	Kidney
COSM1100864	c.6996G>A	p.W2332*	Substitution - Nonsense	Endometrium
COSM1457690	c.1515G>A	p.Q505Q	Substitution - coding silent	Large_intestine
COSM4855736	c.2021C>T	p.P674L	Substitution - Missense	Cervix
COSM4566009	c.2880_2881GG>AA	p.E961K	Substitution - Missense	Skin
COSM3900857	c.1096C>T	p.P366S	Substitution - Missense	Stomach
COSM5723933	c.3764C>T	p.P1255L	Substitution - Missense	Skin
COSM4960516	c.5469G>A	p.M1823I	Substitution - Missense	Liver
COSM1457715	c.4079T>G	p.F1360C	Substitution - Missense	Large_intestine
COSM1457746	c.7469C>T	p.S2490L	Substitution - Missense	Skin
COSM1201000	c.7172C>T	p.A2391V	Substitution - Missense	Large_intestine
COSM3929609	c.3122T>G	p.L1041W	Substitution - Missense	Central_nervous_system
COSM4438873	c.7080G>A	p.K2360K	Substitution - coding silent	Oesophagus
COSM5587488	c.1453C>T	p.L485F	Substitution - Missense	Skin
COSM1195233	c.1406G>A	p.R469K	Substitution - Missense	Lung
COSM3900851	c.360C>T	p.G120G	Substitution - coding silent	Stomach
COSM5634627	c.7989G>A	p.A2663A	Substitution - coding silent	Oesophagus
COSM1330933	c.7761A>G	p.K2587K	Substitution - coding silent	Ovary
COSM5979533	c.8428T>A	p.F2810I	Substitution - Missense	Upper_aerodigestive_tract
COSM4490742	c.3689C>T	p.S1230F	Substitution - Missense	Skin
COSM5063274	c.470G>A	p.R157Q	Substitution - Missense	Stomach
COSM486565	c.5106C>T	p.S1702S	Substitution - coding silent	Kidney
COSM1100812	c.3709A>G	p.N1237D	Substitution - Missense	Endometrium
COSM1100910	c.8532G>T	p.E2844D	Substitution - Missense	Endometrium
COSM3382277	c.1266G>T	p.M422I	Substitution - Missense	Pancreas
COSM3650070	c.3087C>T	p.P1029P	Substitution - coding silent	Skin
COSM159984	c.2552G>A	p.R851K	Substitution - Missense	Breast
COSM5067886	c.8955_8956insG	p.D2988fs*2	Insertion - Frameshift	Large_intestine
COSM255647	c.5533_5534insT	p.G1845fs*5	Insertion - Frameshift	Central_nervous_system
COSM4479645	c.2346C>T	p.S782S	Substitution - coding silent	Skin
COSM3900877	c.6212A>G	p.H2071R	Substitution - Missense	Stomach
COSM4187893	c.7988C>T	p.A2663V	Substitution - Missense	Kidney
COSM3738166	c.5494G>C	p.E1832Q	Substitution - Missense	Soft_tissue
COSM1100894	c.7525A>G	p.M2509V	Substitution - Missense	Endometrium
COSM216817	c.3048T>A	p.H1016Q	Substitution - Missense	Pancreas
COSM3432490	c.8594C>T	p.S2865L	Substitution - Missense	Large_intestine
COSM1330939	c.2426G>A	p.R809H	Substitution - Missense	Ovary
COSM1100791	c.2478C>A	p.F826L	Substitution - Missense	Endometrium
COSM6007446	c.5228G>A	p.R1743H	Substitution - Missense	Prostate
COSM4494828	c.4404C>T	p.A1468A	Substitution - coding silent	Skin
COSM486569	c.5459G>A	p.R1820Q	Substitution - Missense	Kidney
COSM3737970	c.2482G>A	p.V828M	Substitution - Missense	Soft_tissue
COSM5656562	c.6366A>G	p.L2122L	Substitution - coding silent	Soft_tissue
COSM85121	c.8552A>G	p.E2851G	Substitution - Missense	Pancreas
COSM4787742	c.1591C>A	p.H531N	Substitution - Missense	Liver
COSM4796063	c.3399G>A	p.T1133T	Substitution - coding silent	Liver
COSM391948	c.3023_3030delATGAGATA	p.Y1008fs*42	Deletion - Frameshift	Lung
COSM4747354	c.5997_6014del18	p.F2000_K2005delFARLDK	Deletion - In frame	Stomach
COSM333123	c.2451T>C	p.S817S	Substitution - coding silent	Lung
COSM2720153	c.7668C>T	p.N2556N	Substitution - coding silent	Large_intestine
COSM3834871	c.223T>C	p.Y75H	Substitution - Missense	Breast
COSM1314134	c.2960G>A	p.R987Q	Substitution - Missense	Cervix
COSM3650068	c.1762C>T	p.P588S	Substitution - Missense	Skin
COSM751033	c.8450A>T	p.N2817I	Substitution - Missense	Lung
COSM4756290	c.5818C>T	p.R1940C	Substitution - Missense	Stomach
COSM3942705	c.299C>G	p.S100C	Substitution - Missense	Oesophagus
COSM4803519	c.6087C>T	p.P2029P	Substitution - coding silent	Liver
COSM1724744	c.3769C>T	p.L1257F	Substitution - Missense	Skin
COSM1201006	c.5960C>A	p.P1987H	Substitution - Missense	Large_intestine
COSM3699126	c.5405-1G>T	p.?	Unknown	Large_intestine
COSM3951755	c.6716A>T	p.E2239V	Substitution - Missense	Lung
COSM5939783	c.2210C>T	p.P737L	Substitution - Missense	Skin
COSM5629191	c.8273T>C	p.L2758P	Substitution - Missense	Oesophagus
COSM81019	c.4374A>G	p.K1458K	Substitution - coding silent	Ovary
COSM1100849	c.5741G>A	p.R1914H	Substitution - Missense	Endometrium
COSM751053	c.4778G>T	p.R1593L	Substitution - Missense	Endometrium
COSM1201002	c.4822A>G	p.R1608G	Substitution - Missense	Large_intestine
COSM3650069	c.2657G>A	p.R886Q	Substitution - Missense	Skin
COSM5443897	c.6604G>C	p.E2202Q	Substitution - Missense	Oesophagus
COSM3650083	c.6710C>T	p.S2237F	Substitution - Missense	Skin
COSM5037984	c.4394G>A	p.R1465Q	Substitution - Missense	Skin
COSM461417	c.6097G>C	p.D2033H	Substitution - Missense	Cervix
COSM5492386	c.5211-3C>A	p.?	Unknown	Biliary_tract
COSM5069258	c.3254A>G	p.E1085G	Substitution - Missense	Large_intestine
COSM1100919	c.8789C>T	p.A2930V	Substitution - Missense	Endometrium
COSM3900882	c.7472G>A	p.R2491H	Substitution - Missense	Stomach
COSM3395366	c.515C>T	p.P172L	Substitution - Missense	Pancreas
COSM41606	c.1668_2613dup	p.556_871dup	Insertion - In frame	Lung
COSM1624107	c.6630G>A	p.E2210E	Substitution - coding silent	Liver
COSM5790273	c.1728G>T	p.P576P	Substitution - coding silent	Breast
COSM4828599	c.7204A>G	p.R2402G	Substitution - Missense	Cervix
COSM5409745	c.4760C>T	p.P1587L	Substitution - Missense	Skin
COSM4789643	c.947G>T	p.S316I	Substitution - Missense	Liver
COSM5699454	c.7213A>T	p.R2405*	Substitution - Nonsense	Soft_tissue
COSM1100852	c.5926C>T	p.R1976C	Substitution - Missense	Endometrium
COSM4163031	c.3240C>A	p.I1080I	Substitution - coding silent	Thyroid
COSM1100879	c.7253G>A	p.R2418Q	Substitution - Missense	Stomach
COSM4672081	c.712G>A	p.V238M	Substitution - Missense	Large_intestine
COSM4367718	c.3293C>T	p.P1098L	Substitution - Missense	Skin
COSM5584788	c.899C>T	p.P300L	Substitution - Missense	Skin
COSM751061	c.3379G>A	p.E1127K	Substitution - Missense	Lung
COSM1100873	c.7193G>A	p.R2398H	Substitution - Missense	Endometrium
COSM1457734	c.6287A>T	p.H2096L	Substitution - Missense	Large_intestine
COSM2720165	c.8478C>T	p.N2826N	Substitution - coding silent	Large_intestine
COSM5358908	c.5221C>G	p.R1741G	Substitution - Missense	Large_intestine
COSM5691607	c.5649G>T	p.M1883I	Substitution - Missense	Soft_tissue
COSM5947530	c.550C>T	p.Q184*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM4445215	c.568_569delGG	p.G190fs*96	Deletion - Frameshift	Large_intestine
COSM1100767	c.258G>A	p.P86P	Substitution - coding silent	Large_intestine
COSM4445221	c.8250T>G	p.F2750L	Substitution - Missense	Large_intestine
COSM1100882	c.7266G>A	p.E2422E	Substitution - coding silent	Endometrium
COSM1489360	c.6739G>T	p.D2247Y	Substitution - Missense	Breast
COSM5038751	c.8858_8876del19	p.L2953fs*13	Deletion - Frameshift	Liver
COSM4950585	c.5638G>T	p.E1880*	Substitution - Nonsense	Liver
COSM4939531	c.7413A>G	p.S2471S	Substitution - coding silent	Liver
COSM383559	c.8519C>A	p.T2840N	Substitution - Missense	Lung
COSM1100834	c.5428C>T	p.R1810*	Substitution - Nonsense	Endometrium
COSM3951752	c.3998A>G	p.Y1333C	Substitution - Missense	Lung
COSM4506374	c.7188C>T	p.V2396V	Substitution - coding silent	Skin
COSM216817	c.3048T>A	p.H1016Q	Substitution - Missense	Pancreas
COSM4989042	c.805G>A	p.V269I	Substitution - Missense	Soft_tissue
COSM3925441	c.3640C>T	p.Q1214*	Substitution - Nonsense	Skin
COSM3650067	c.1543C>T	p.P515S	Substitution - Missense	Skin
COSM1457705	c.3674A>G	p.N1225S	Substitution - Missense	Large_intestine
COSM5067886	c.8955_8956insG	p.D2988fs*2	Insertion - Frameshift	Breast
COSM4949522	c.4353G>C	p.G1451G	Substitution - coding silent	Liver
COSM5669231	c.859C>A	p.P287T	Substitution - Missense	Soft_tissue
COSM1314140	c.5898G>C	p.W1966C	Substitution - Missense	Urinary_tract
COSM5912749	c.2636C>T	p.P879L	Substitution - Missense	Skin
COSM1569595	c.7504C>G	p.L2502V	Substitution - Missense	Large_intestine
COSM1100831	c.5114C>T	p.P1705L	Substitution - Missense	Endometrium
COSM3650086	c.6923C>T	p.S2308L	Substitution - Missense	Skin
COSM2151583	c.7470G>A	p.S2490S	Substitution - coding silent	Central_nervous_system
COSM3834872	c.1103A>C	p.H368P	Substitution - Missense	Breast
COSM255230	c.2904_2932del29	p.R969fs*16	Deletion - Frameshift	Central_nervous_system
COSM5594403	c.5839G>A	p.E1947K	Substitution - Missense	Skin
COSM751045	c.6068G>T	p.R2023M	Substitution - Missense	Lung
COSM4959541	c.2017G>A	p.A673T	Substitution - Missense	Liver
COSM4503209	c.6348C>T	p.I2116I	Substitution - coding silent	Skin
COSM2720137	c.6956G>A	p.R2319H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5979531	c.694C>A	p.P232T	Substitution - Missense	Upper_aerodigestive_tract
COSM2720158	c.8141C>T	p.A2714V	Substitution - Missense	Pancreas
COSM1100843	c.5604A>G	p.I1868M	Substitution - Missense	Endometrium
COSM4500316	c.5623C>T	p.P1875S	Substitution - Missense	Skin
COSM5912750	c.6079C>T	p.R2027*	Substitution - Nonsense	Skin
COSM5696293	c.6639_6640delTG	p.V2214fs*3	Deletion - Frameshift	Soft_tissue
COSM3900879	c.6665A>G	p.E2222G	Substitution - Missense	Stomach
COSM4790088	c.1124A>G	p.Q375R	Substitution - Missense	Liver
COSM461415	c.6587C>T	p.T2196I	Substitution - Missense	Cervix
COSM751073	c.1962G>T	p.K654N	Substitution - Missense	Lung
COSM4971346	c.6965delA	p.N2322fs*7	Deletion - Frameshift	Central_nervous_system
COSM383557	c.7076A>G	p.Q2359R	Substitution - Missense	Lung
COSM4959541	c.2017G>A	p.A673T	Substitution - Missense	Liver
COSM2152177	c.5783A>T	p.Q1928L	Substitution - Missense	Central_nervous_system
COSM1190803	c.698delG	p.G233fs*72	Deletion - Frameshift	Lung
COSM3900864	c.3679A>G	p.T1227A	Substitution - Missense	Stomach
COSM4842143	c.7843G>C	p.V2615L	Substitution - Missense	Cervix
COSM5421990	c.5300+1G>T	p.?	Unknown	Prostate
COSM384137	c.4894C>T	p.R1632C	Substitution - Missense	Lung
COSM4506509	c.7221C>T	p.I2407I	Substitution - coding silent	Skin
COSM226632	c.6529G>A	p.E2177K	Substitution - Missense	Breast
COSM486563	c.4823G>A	p.R1608K	Substitution - Missense	Kidney
COSM255543	c.5307delC	p.D1770fs*26	Deletion - Frameshift	Central_nervous_system
COSM5574494	c.2119G>T	p.A707S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1314134	c.2960G>A	p.R987Q	Substitution - Missense	Urinary_tract
COSM1100779	c.803C>T	p.S268F	Substitution - Missense	Skin
COSM1238501	c.2619G>A	p.E873E	Substitution - coding silent	Oesophagus
COSM751085	c.308C>T	p.S103L	Substitution - Missense	Lung
COSM4850256	c.74G>A	p.G25E	Substitution - Missense	Cervix
COSM2720159	c.8196C>T	p.A2732A	Substitution - coding silent	Ovary
COSM1100876	c.7198C>T	p.R2400W	Substitution - Missense	Endometrium
COSM2720012	c.2201_2203delCTC	p.P737delP	Deletion - In frame	Large_intestine
COSM2720132	c.6744C>T	p.D2248D	Substitution - coding silent	Large_intestine
COSM1200996	c.3988C>T	p.R1330W	Substitution - Missense	Large_intestine
COSM4488958	c.3406C>T	p.P1136S	Substitution - Missense	Skin
COSM5783268	c.3778+9G>T	p.?	Unknown	Breast
COSM5063276	c.3490C>T	p.Q1164*	Substitution - Nonsense	Stomach
COSM4404450	c.4065T>C	p.P1355P	Substitution - coding silent	Skin
COSM5900117	c.2446G>A	p.E816K	Substitution - Missense	Skin
COSM5979531	c.694C>A	p.P232T	Substitution - Missense	Upper_aerodigestive_tract
COSM3650082	c.6473C>T	p.S2158L	Substitution - Missense	Skin
COSM1314132	c.1394C>A	p.S465Y	Substitution - Missense	Urinary_tract
COSM4880837	c.5545G>T	p.D1849Y	Substitution - Missense	Prostate
COSM1100767	c.258G>A	p.P86P	Substitution - coding silent	Biliary_tract
COSM5672977	c.134A>T	p.Q45L	Substitution - Missense	Soft_tissue
COSM5723933	c.3764C>T	p.P1255L	Substitution - Missense	Skin
COSM5516011	c.3198C>A	p.P1066P	Substitution - coding silent	Biliary_tract
COSM3650074	c.3655C>T	p.R1219*	Substitution - Nonsense	Skin
COSM396308	c.8294A>T	p.Q2765L	Substitution - Missense	Lung
COSM1314130	c.34G>A	p.E12K	Substitution - Missense	Urinary_tract
COSM1248221	c.5029C>G	p.R1677G	Substitution - Missense	Oesophagus
COSM1100797	c.2552G>T	p.R851I	Substitution - Missense	Endometrium
COSM3900865	c.3711C>T	p.N1237N	Substitution - coding silent	Stomach
COSM1100855	c.6038A>C	p.K2013T	Substitution - Missense	Endometrium
COSM397896	c.5211-1G>T	p.?	Unknown	Lung
COSM3900859	c.1687C>G	p.L563V	Substitution - Missense	Stomach
COSM5660169	c.1418G>T	p.G473V	Substitution - Missense	Soft_tissue
COSM2720160	c.8213C>T	p.T2738M	Substitution - Missense	Stomach
COSM3650084	c.6770C>T	p.P2257L	Substitution - Missense	Skin
COSM751071	c.2133G>A	p.K711K	Substitution - coding silent	Lung
COSM1100870	c.7145C>T	p.T2382M	Substitution - Missense	Endometrium
COSM1457696	c.1947delA	p.D652fs*59	Deletion - Frameshift	Large_intestine
COSM5516434	c.8556C>T	p.D2852D	Substitution - coding silent	Biliary_tract
COSM5892004	c.2605C>T	p.L869F	Substitution - Missense	Skin
COSM1200998	c.4067A>G	p.D1356G	Substitution - Missense	Large_intestine
COSM5601238	c.8420C>T	p.P2807L	Substitution - Missense	Skin
COSM2151583	c.7470G>A	p.S2490S	Substitution - coding silent	Central_nervous_system
COSM2720150	c.7537C>T	p.R2513W	Substitution - Missense	Large_intestine
COSM5026921	c.2862G>A	p.K954K	Substitution - coding silent	Breast
COSM5691608	c.7604G>C	p.S2535T	Substitution - Missense	Soft_tissue
COSM1100904	c.8175C>T	p.I2725I	Substitution - coding silent	Endometrium
COSM4944410	c.2820G>T	p.P940P	Substitution - coding silent	Liver
COSM1457726	c.4623T>C	p.D1541D	Substitution - coding silent	Large_intestine
COSM4163030	c.1918G>A	p.E640K	Substitution - Missense	Thyroid
COSM1100870	c.7145C>T	p.T2382M	Substitution - Missense	Endometrium
COSM50728	c.3953G>A	p.C1318Y	Substitution - Missense	Large_intestine
COSM3413081	c.7604G>A	p.S2535N	Substitution - Missense	Central_nervous_system
COSM4163032	c.3495A>G	p.E1165E	Substitution - coding silent	Thyroid
COSM3703416	c.7510G>A	p.D2504N	Substitution - Missense	Liver
COSM751079	c.1214C>T	p.P405L	Substitution - Missense	Lung
COSM239315	c.5740C>T	p.R1914C	Substitution - Missense	Prostate
COSM3900861	c.2839C>T	p.R947*	Substitution - Nonsense	Stomach
COSM4445220	c.5488G>T	p.A1830S	Substitution - Missense	Large_intestine
COSM4776467	c.5532C>T	p.D1844D	Substitution - coding silent	Soft_tissue
COSM751065	c.3142G>T	p.G1048W	Substitution - Missense	Lung
COSM1100916	c.8627C>A	p.A2876D	Substitution - Missense	Endometrium
COSM4917553	c.6311C>T	p.A2104V	Substitution - Missense	Liver
COSM260095	c.3051C>T	p.G1017G	Substitution - coding silent	Large_intestine
COSM1100849	c.5741G>A	p.R1914H	Substitution - Missense	Stomach
COSM3925444	c.8908C>T	p.L2970F	Substitution - Missense	Skin
COSM3900868	c.3866C>T	p.A1289V	Substitution - Missense	Stomach
COSM4550781	c.5092G>A	p.V1698M	Substitution - Missense	Skin
COSM1201008	c.2573G>A	p.R858Q	Substitution - Missense	Large_intestine
COSM266240	c.2750C>T	p.T917M	Substitution - Missense	Large_intestine
COSM3367385	c.5620T>C	p.S1874P	Substitution - Missense	Kidney
COSM3942706	c.8424C>T	p.N2808N	Substitution - coding silent	Large_intestine
COSM2720082	c.4778G>A	p.R1593H	Substitution - Missense	Large_intestine
COSM1457755	c.8956delG	p.D2988fs*3	Deletion - Frameshift	Large_intestine
COSM4502402	c.6123C>T	p.S2041S	Substitution - coding silent	Skin
COSM210952	c.7526T>C	p.M2509T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM454723	c.1977C>A	p.P659P	Substitution - coding silent	Breast
COSM4399308	c.6425C>T	p.S2142F	Substitution - Missense	Skin
COSM1635835	c.4922C>A	p.T1641N	Substitution - Missense	Liver
COSM3900847	c.84T>C	p.G28G	Substitution - coding silent	Stomach
COSM3900872	c.5053T>C	p.L1685L	Substitution - coding silent	Stomach
COSM4500316	c.5623C>T	p.P1875S	Substitution - Missense	Thyroid
COSM81018	c.3687T>G	p.L1229L	Substitution - coding silent	Ovary
COSM5039413	c.5518G>A	p.A1840T	Substitution - Missense	Liver
COSM1457696	c.1947delA	p.D652fs*59	Deletion - Frameshift	Large_intestine
COSM4789643	c.947G>T	p.S316I	Substitution - Missense	Liver
COSM4950585	c.5638G>T	p.E1880*	Substitution - Nonsense	Liver
COSM243676	c.2238G>T	p.Q746H	Substitution - Missense	Prostate
COSM3900852	c.748C>T	p.R250C	Substitution - Missense	Stomach
COSM4512288	c.898C>T	p.P300S	Substitution - Missense	Skin
COSM1457686	c.501G>A	p.P167P	Substitution - coding silent	Large_intestine
COSM3951757	c.8629G>T	p.A2877S	Substitution - Missense	Lung
COSM4787742	c.1591C>A	p.H531N	Substitution - Missense	Liver
COSM5063278	c.6194G>A	p.R2065H	Substitution - Missense	Stomach
COSM5950772	c.5534+2T>G	p.?	Unknown	Prostate
COSM5358736	c.6195C>T	p.R2065R	Substitution - coding silent	Large_intestine
COSM3763365	c.6135G>A	p.P2045P	Substitution - coding silent	Large_intestine
COSM4833836	c.4205G>C	p.R1402T	Substitution - Missense	Cervix
COSM3675145	c.717C>A	p.P239P	Substitution - coding silent	Prostate
COSM4502757	c.6215C>T	p.P2072L	Substitution - Missense	Skin
COSM347772	c.3451T>A	p.L1151M	Substitution - Missense	Lung
COSM1457746	c.7469C>T	p.S2490L	Substitution - Missense	Large_intestine
COSM3650087	c.7502C>T	p.S2501F	Substitution - Missense	Skin
COSM4950448	c.2666A>C	p.D889A	Substitution - Missense	Liver
COSM486567	c.5380C>A	p.L1794I	Substitution - Missense	Kidney
COSM3900883	c.7536G>A	p.R2512R	Substitution - coding silent	Stomach
COSM3650064	c.297G>C	p.A99A	Substitution - coding silent	Skin
COSM1100800	c.2572C>T	p.R858*	Substitution - Nonsense	Large_intestine
COSM2720037	c.3105C>T	p.F1035F	Substitution - coding silent	Large_intestine
COSM239313	c.5396T>A	p.F1799Y	Substitution - Missense	Prostate
COSM4672082	c.1012A>G	p.T338A	Substitution - Missense	Large_intestine
COSM1457722	c.4540T>G	p.F1514V	Substitution - Missense	Large_intestine
COSM3900856	c.1075C>G	p.Q359E	Substitution - Missense	Stomach
COSM3900875	c.6108G>A	p.P2036P	Substitution - coding silent	Stomach
COSM4548049	c.4381G>C	p.E1461Q	Substitution - Missense	Skin
COSM3834873	c.1537A>T	p.T513S	Substitution - Missense	Breast
COSM3900848	c.89C>T	p.P30L	Substitution - Missense	Stomach
COSM5067886	c.8955_8956insG	p.D2988fs*2	Insertion - Frameshift	Large_intestine
COSM1100891	c.7485G>T	p.R2495S	Substitution - Missense	Endometrium
COSM255886	c.2739_2740delTG	p.Y913fs*1	Deletion - Frameshift	Central_nervous_system
COSM4399308	c.6425C>T	p.S2142F	Substitution - Missense	Skin
COSM5026922	c.8356G>A	p.G2786R	Substitution - Missense	Breast
COSM2720003	c.1703C>T	p.P568L	Substitution - Missense	Cervix
COSM3650071	c.3178G>A	p.E1060K	Substitution - Missense	Skin
COSM364788	c.8640G>T	p.P2880P	Substitution - coding silent	Lung
COSM5409747	c.7335A>T	p.S2445S	Substitution - coding silent	Skin
COSM751081	c.1063T>C	p.S355P	Substitution - Missense	Lung
COSM2720001	c.1574A>G	p.H525R	Substitution - Missense	Large_intestine
COSM3650075	c.3898C>T	p.P1300S	Substitution - Missense	Skin
COSM3900885	c.8353G>A	p.A2785T	Substitution - Missense	Stomach
COSM5345617	c.3560T>C	p.L1187S	Substitution - Missense	Large_intestine
COSM454719	c.215A>G	p.Y72C	Substitution - Missense	Large_intestine
COSM1457746	c.7469C>T	p.S2490L	Substitution - Missense	Large_intestine
COSM3663820	c.8439C>T	p.G2813G	Substitution - coding silent	Liver
COSM3925443	c.8455C>T	p.P2819S	Substitution - Missense	Skin
COSM1100824	c.4603G>A	p.A1535T	Substitution - Missense	Endometrium
COSM454729	c.6261G>C	p.L2087L	Substitution - coding silent	Breast
COSM1457696	c.1947delA	p.D652fs*59	Deletion - Frameshift	Large_intestine
COSM2720079	c.181C>T	p.Q61*	Substitution - Nonsense	Breast
COSM1457724	c.4607A>G	p.K1536R	Substitution - Missense	Large_intestine
COSM4921282	c.4859G>T	p.R1620L	Substitution - Missense	Liver
COSM5947531	c.5859G>T	p.A1953A	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4960516	c.5469G>A	p.M1823I	Substitution - Missense	Liver
COSM4961604	c.7683A>G	p.G2561G	Substitution - coding silent	Pancreas
COSM1100773	c.400C>T	p.H134Y	Substitution - Missense	Endometrium
COSM5358908	c.5221C>G	p.R1741G	Substitution - Missense	Large_intestine
COSM1330937	c.4142G>T	p.C1381F	Substitution - Missense	Ovary
COSM216817	c.3048T>A	p.H1016Q	Substitution - Missense	Pancreas
COSM1100879	c.7253G>A	p.R2418Q	Substitution - Missense	Endometrium
COSM5919502	c.5088G>T	p.K1696N	Substitution - Missense	Skin
COSM3650081	c.6368C>T	p.S2123F	Substitution - Missense	Skin
COSM3929608	c.64G>C	p.E22Q	Substitution - Missense	Central_nervous_system
COSM2720132	c.6744C>T	p.D2248D	Substitution - coding silent	Large_intestine
COSM5520697	c.8731C>A	p.P2911T	Substitution - Missense	Biliary_tract
COSM1100818	c.4268A>G	p.E1423G	Substitution - Missense	Endometrium
COSM2719979	c.884G>A	p.R295Q	Substitution - Missense	Large_intestine
COSM1457744	c.7372T>G	p.F2458V	Substitution - Missense	Large_intestine
COSM4802623	c.3539C>T	p.A1180V	Substitution - Missense	Liver
COSM4428022	c.2130G>A	p.L710L	Substitution - coding silent	Oesophagus
COSM50729	c.6022G>C	p.D2008H	Substitution - Missense	Breast
COSM486575	c.7892G>A	p.R2631Q	Substitution - Missense	Kidney
COSM4802623	c.3539C>T	p.A1180V	Substitution - Missense	Liver
COSM1489368	c.8382T>A	p.A2794A	Substitution - coding silent	Breast
COSM5976890	c.7716C>T	p.I2572I	Substitution - coding silent	Upper_aerodigestive_tract
COSM4672089	c.5711C>A	p.P1904H	Substitution - Missense	Large_intestine
COSM454721	c.1873G>C	p.D625H	Substitution - Missense	Breast
COSM751067	c.3019C>T	p.L1007F	Substitution - Missense	Lung
COSM4445216	c.2195delC	p.P732fs*23	Deletion - Frameshift	Large_intestine
COSM3900887	c.8869G>A	p.D2957N	Substitution - Missense	Stomach
COSM5063277	c.4882G>A	p.G1628R	Substitution - Missense	Stomach
COSM159984	c.2552G>A	p.R851K	Substitution - Missense	Breast
COSM1100885	c.7373T>G	p.F2458C	Substitution - Missense	Endometrium
COSM1187551	c.4462G>T	p.D1488Y	Substitution - Missense	Lung
COSM1457750	c.7894A>C	p.N2632H	Substitution - Missense	Large_intestine
COSM1457688	c.1068C>T	p.N356N	Substitution - coding silent	Large_intestine
COSM2720035	c.3080C>T	p.T1027I	Substitution - Missense	Large_intestine
COSM226632	c.6529G>A	p.E2177K	Substitution - Missense	Skin
COSM4482928	c.2655C>T	p.D885D	Substitution - coding silent	Skin
COSM3900871	c.5034C>T	p.A1678A	Substitution - coding silent	Stomach
COSM1100809	c.3588G>T	p.K1196N	Substitution - Missense	Endometrium
COSM4626248	c.3027G>A	p.E1009E	Substitution - coding silent	Large_intestine
COSM5780471	c.6283C>T	p.R2095W	Substitution - Missense	Breast
COSM3900873	c.5766C>T	p.R1922R	Substitution - coding silent	Stomach
COSM1319701	c.7199_7201delGGA	p.R2405delR	Deletion - In frame	Upper_aerodigestive_tract
COSM3900867	c.3756C>T	p.C1252C	Substitution - coding silent	Stomach
COSM5677520	c.7009C>T	p.R2337C	Substitution - Missense	Soft_tissue
COSM5919500	c.3574G>A	p.E1192K	Substitution - Missense	Skin
COSM5905746	c.7609G>A	p.E2537K	Substitution - Missense	Skin
COSM255647	c.5533_5534insT	p.G1845fs*5	Insertion - Frameshift	Central_nervous_system
COSM1100815	c.3950G>A	p.R1317H	Substitution - Missense	Endometrium
COSM4428346	c.6664G>C	p.E2222Q	Substitution - Missense	Oesophagus
COSM5782556	c.4161C>A	p.D1387E	Substitution - Missense	Breast
COSM260091	c.1791G>T	p.K597N	Substitution - Missense	Large_intestine
COSM5723933	c.3764C>T	p.P1255L	Substitution - Missense	Skin
COSM3779297	c.1524T>C	p.F508F	Substitution - coding silent	Urinary_tract
COSM2152177	c.5783A>T	p.Q1928L	Substitution - Missense	Central_nervous_system
COSM422093	c.951C>G	p.N317K	Substitution - Missense	Urinary_tract
COSM751049	c.4941G>C	p.L1647L	Substitution - coding silent	Lung
COSM751037	c.7234G>C	p.E2412Q	Substitution - Missense	Lung
COSM3900858	c.1351G>A	p.G451S	Substitution - Missense	Stomach
COSM4829833	c.8589T>C	p.A2863A	Substitution - coding silent	Cervix
COSM3925442	c.6966C>T	p.N2322N	Substitution - coding silent	Skin
COSM3374963	c.2222A>G	p.E741G	Substitution - Missense	Thyroid
COSM1624107	c.6630G>A	p.E2210E	Substitution - coding silent	Liver
COSM454727	c.5440G>A	p.A1814T	Substitution - Missense	Breast
COSM1158133	c.3208G>A	p.V1070M	Substitution - Missense	Pancreas
COSM486571	c.6971G>A	p.C2324Y	Substitution - Missense	Kidney
COSM5512490	c.7958G>A	p.R2653Q	Substitution - Missense	Biliary_tract
COSM1201008	c.2573G>A	p.R858Q	Substitution - Missense	Large_intestine
COSM6007445	c.2167G>A	p.E723K	Substitution - Missense	Prostate
COSM3900862	c.3346A>G	p.K1116E	Substitution - Missense	Stomach
COSM5695406	c.985A>T	p.N329Y	Substitution - Missense	Soft_tissue
COSM5979532	c.2680A>G	p.T894A	Substitution - Missense	Upper_aerodigestive_tract
COSM1100846	c.5632G>A	p.D1878N	Substitution - Missense	Endometrium
COSM2720112	c.5927G>A	p.R1976H	Substitution - Missense	Upper_aerodigestive_tract
COSM1319701	c.7199_7201delGGA	p.R2405delR	Deletion - In frame	Haematopoietic_and_lymphoid_tissue
COSM1100913	c.8616A>G	p.G2872G	Substitution - coding silent	Endometrium
COSM5409744	c.2076C>T	p.P692P	Substitution - coding silent	Skin
COSM1489358	c.6571G>C	p.E2191Q	Substitution - Missense	Breast
COSM3900874	c.5816G>A	p.R1939Q	Substitution - Missense	Stomach
COSM1100767	c.258G>A	p.P86P	Substitution - coding silent	Large_intestine
COSM1292720	c.2820G>A	p.P940P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1100770	c.292C>A	p.L98I	Substitution - Missense	Endometrium
COSM751057	c.4104A>T	p.A1368A	Substitution - coding silent	Lung
COSM2720167	c.8610G>A	p.A2870A	Substitution - coding silent	Large_intestine
COSM751053	c.4778G>T	p.R1593L	Substitution - Missense	Lung
COSM353605	c.7672C>T	p.P2558S	Substitution - Missense	Endometrium
COSM4515706	c.1261_1262CC>TT	p.P421L	Substitution - Missense	Skin
COSM1489366	c.8096T>A	p.M2699K	Substitution - Missense	Breast
COSM3738213	c.3583G>T	p.E1195*	Substitution - Nonsense	Soft_tissue
COSM4445162	c.583C>T	p.R195C	Substitution - Missense	Large_intestine
COSM4672092	c.8355C>T	p.A2785A	Substitution - coding silent	Large_intestine
COSM3669911	c.3206G>C	p.R1069P	Substitution - Missense	Liver
COSM2719991	c.1167T>G	p.T389T	Substitution - coding silent	Stomach
COSM1100794	c.2545G>T	p.D849Y	Substitution - Missense	Endometrium
COSM4672084	c.2627delT	p.F877fs*11	Deletion - Frameshift	Large_intestine
COSM4443600	c.6335C>T	p.T2112M	Substitution - Missense	Large_intestine
COSM1330941	c.405G>A	p.G135G	Substitution - coding silent	Ovary
COSM1457717	c.4111T>G	p.L1371V	Substitution - Missense	Large_intestine
COSM1472102	c.8397G>A	p.M2799I	Substitution - Missense	Prostate
COSM1730606	c.5944G>T	p.G1982W	Substitution - Missense	Liver
COSM5991840	c.529delC	p.P178fs*33	Deletion - Frameshift	Prostate
COSM3650078	c.4334G>C	p.R1445T	Substitution - Missense	Skin
COSM4445162	c.583C>T	p.R195C	Substitution - Missense	Large_intestine
COSM1100840	c.5530G>T	p.D1844Y	Substitution - Missense	Endometrium
COSM3900876	c.6158G>A	p.R2053Q	Substitution - Missense	Stomach
COSM1100764	c.76G>T	p.E26*	Substitution - Nonsense	Endometrium
COSM751063	c.3261T>A	p.I1087I	Substitution - coding silent	Lung
COSM3900875	c.6108G>A	p.P2036P	Substitution - coding silent	Stomach
COSM1330935	c.4393C>T	p.R1465*	Substitution - Nonsense	Ovary
COSM4769553	c.8150G>A	p.R2717K	Substitution - Missense	Biliary_tract
COSM2720061	c.3856A>G	p.I1286V	Substitution - Missense	Large_intestine
COSM1100812	c.3709A>G	p.N1237D	Substitution - Missense	Breast
COSM751043	c.6514G>A	p.E2172K	Substitution - Missense	Lung
COSM4445213	c.1024delC	p.Q342fs*10	Deletion - Frameshift	Large_intestine
COSM5935378	c.686C>T	p.T229I	Substitution - Missense	Skin
COSM5409746	c.6240C>T	p.L2080L	Substitution - coding silent	Skin
COSM4445217	c.2920G>T	p.E974*	Substitution - Nonsense	Large_intestine
COSM5889043	c.1589C>T	p.P530L	Substitution - Missense	Skin
COSM1187549	c.1922A>T	p.K641I	Substitution - Missense	Lung
COSM4616112	c.7658_7660delCAA	p.T2554delT	Deletion - In frame	Large_intestine
COSM1100767	c.258G>A	p.P86P	Substitution - coding silent	Endometrium
COSM3650065	c.707C>T	p.S236F	Substitution - Missense	Skin
COSM4765253	c.1919_1920insA	p.K643fs*33	Insertion - Frameshift	Stomach
COSM3900869	c.4130C>T	p.A1377V	Substitution - Missense	Stomach
COSM3900854	c.779C>T	p.P260L	Substitution - Missense	Stomach
COSM3669911	c.3206G>C	p.R1069P	Substitution - Missense	Liver
COSM4138722	c.5344C>A	p.P1782T	Substitution - Missense	Kidney
COSM1457736	c.6352A>G	p.N2118D	Substitution - Missense	Large_intestine
COSM5515256	c.1959G>A	p.P653P	Substitution - coding silent	Biliary_tract
COSM5676319	c.5176A>G	p.S1726G	Substitution - Missense	Soft_tissue
COSM355306	c.7441C>G	p.Q2481E	Substitution - Missense	Lung
COSM1100837	c.5439C>T	p.P1813P	Substitution - coding silent	Endometrium
COSM3900881	c.7222G>A	p.E2408K	Substitution - Missense	Stomach
COSM260093	c.1882G>T	p.E628*	Substitution - Nonsense	Large_intestine
COSM5919503	c.6080G>A	p.R2027Q	Substitution - Missense	Upper_aerodigestive_tract
COSM5791122	c.6173T>G	p.I2058S	Substitution - Missense	Breast
COSM1724744	c.3769C>T	p.L1257F	Substitution - Missense	Skin
COSM5565261	c.7879C>T	p.R2627*	Substitution - Nonsense	Prostate
COSM2720082	c.4778G>A	p.R1593H	Substitution - Missense	Large_intestine
COSM751077	c.1245G>A	p.P415P	Substitution - coding silent	Prostate
COSM5919504	c.3419C>T	p.T1140I	Substitution - Missense	Skin
COSM3834875	c.7328A>C	p.D2443A	Substitution - Missense	Breast
COSM79641	c.3237C>T	p.A1079A	Substitution - coding silent	Ovary
COSM1457728	c.4775G>A	p.R1592Q	Substitution - Missense	Large_intestine
COSM4825583	c.3232C>T	p.H1078Y	Substitution - Missense	Cervix
COSM5656561	c.549delT	p.Q184fs*27	Deletion - Frameshift	Soft_tissue
COSM2720030	c.3017T>C	p.F1006S	Substitution - Missense	Large_intestine
COSM1100776	c.516G>A	p.P172P	Substitution - coding silent	Endometrium
COSM5619858	c.2054C>A	p.A685E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3716029	c.6163C>A	p.L2055M	Substitution - Missense	Upper_aerodigestive_tract
COSM4635618	c.8193C>T	p.A2731A	Substitution - coding silent	Large_intestine
COSM1457730	c.5405-2A>C	p.?	Unknown	Large_intestine
COSM4672088	c.5067G>A	p.V1689V	Substitution - coding silent	Large_intestine
COSM3951753	c.4024G>A	p.G1342S	Substitution - Missense	Lung
COSM237195	c.6924G>A	p.S2308S	Substitution - coding silent	Prostate
COSM5434596	c.6598G>A	p.G2200R	Substitution - Missense	Oesophagus
COSM3766787	c.3807T>G	p.F1269L	Substitution - Missense	Liver
COSM4756291	c.8915A>C	p.E2972A	Substitution - Missense	Stomach
COSM5358736	c.6195C>T	p.R2065R	Substitution - coding silent	Large_intestine
COSM4940895	c.4052G>A	p.R1351K	Substitution - Missense	Liver
COSM454719	c.215A>G	p.Y72C	Substitution - Missense	Breast
COSM5757234	c.6776C>A	p.A2259E	Substitution - Missense	Large_intestine
COSM3779298	c.1687C>T	p.L563L	Substitution - coding silent	Urinary_tract
COSM4911370	c.5842G>A	p.V1948M	Substitution - Missense	Liver
COSM4445218	c.3059delT	p.L1020fs*1	Deletion - Frameshift	Large_intestine
COSM3982557	c.2831G>A	p.R944H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4006947	c.3525G>A	p.V1175V	Substitution - coding silent	Urinary_tract
COSM353605	c.7672C>T	p.P2558S	Substitution - Missense	Lung
COSM4765254	c.8956_8957insG	p.D2988fs*2	Insertion - Frameshift	Stomach
COSM4913354	c.1878C>A	p.N626K	Substitution - Missense	Liver
COSM5003495	c.7241C>A	p.A2414D	Substitution - Missense	Pancreas
COSM4833919	c.4432G>A	p.E1478K	Substitution - Missense	Cervix
COSM4445214	c.5453_5608-6del716	p.?	Unknown	Large_intestine
COSM3382281	c.5587C>T	p.P1863S	Substitution - Missense	Pancreas
COSM4933858	c.4939C>G	p.L1647V	Substitution - Missense	Liver
COSM3382278	c.3032A>G	p.Y1011C	Substitution - Missense	Pancreas
COSM4596916	c.3967G>T	p.E1323*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM4151536	c.1451G>A	p.G484D	Substitution - Missense	Ovary
COSM1457696	c.1947delA	p.D652fs*59	Deletion - Frameshift	Large_intestine
COSM3996094	c.771T>C	p.H257H	Substitution - coding silent	Kidney
COSM2720152	c.7639G>T	p.E2547*	Substitution - Nonsense	Large_intestine
COSM4672086	c.3746G>A	p.R1249Q	Substitution - Missense	Large_intestine
COSM3900880	c.7204A>C	p.R2402R	Substitution - coding silent	Stomach
COSM1100837	c.5439C>T	p.P1813P	Substitution - coding silent	Stomach
COSM751051	c.4837C>T	p.L1613L	Substitution - coding silent	Lung
COSM1100806	c.3475G>T	p.E1159*	Substitution - Nonsense	Endometrium
COSM486575	c.7892G>A	p.R2631Q	Substitution - Missense	Skin
COSM5512490	c.7958G>A	p.R2653Q	Substitution - Missense	Skin
COSM5815849	c.1541G>C	p.C514S	Substitution - Missense	Liver
COSM3900860	c.1746G>A	p.K582K	Substitution - coding silent	Stomach
COSM1457692	c.1566C>T	p.G522G	Substitution - coding silent	Large_intestine
COSM1100858	c.6410C>T	p.A2137V	Substitution - Missense	Endometrium
COSM1457755	c.8956delG	p.D2988fs*3	Deletion - Frameshift	Large_intestine
COSM1100888	c.7381C>T	p.L2461F	Substitution - Missense	Endometrium
COSM70170	c.8686T>C	p.S2896P	Substitution - Missense	Ovary
COSM370937	c.4608G>T	p.K1536N	Substitution - Missense	Lung
COSM3675146	c.6169C>A	p.R2057S	Substitution - Missense	Prostate
COSM5939782	c.530C>T	p.P177L	Substitution - Missense	Skin
COSM5927495	c.3008C>T	p.S1003F	Substitution - Missense	Skin
COSM341532	c.5124G>T	p.Q1708H	Substitution - Missense	Lung
COSM2720055	c.3696C>T	p.G1232G	Substitution - coding silent	Stomach
COSM1100779	c.803C>T	p.S268F	Substitution - Missense	Endometrium
COSM5345618	c.6453C>T	p.V2151V	Substitution - coding silent	Large_intestine
COSM5910602	c.1292C>T	p.P431L	Substitution - Missense	Skin
COSM3900866	c.3714A>G	p.V1238V	Substitution - coding silent	Stomach
COSM1100867	c.7013A>C	p.Q2338P	Substitution - Missense	Endometrium
COSM5919501	c.2044G>A	p.E682K	Substitution - Missense	Skin
COSM5746873	c.467T>C	p.I156T	Substitution - Missense	Pancreas
COSM299127	c.3791A>C	p.K1264T	Substitution - Missense	Large_intestine
COSM4833953	c.2221G>A	p.E741K	Substitution - Missense	Cervix
COSM751039	c.6804T>A	p.F2268L	Substitution - Missense	Lung
COSM2719978	c.825C>A	p.F275L	Substitution - Missense	Large_intestine
COSM3900850	c.309G>A	p.S103S	Substitution - coding silent	Stomach
COSM5942191	c.5359G>A	p.D1787N	Substitution - Missense	Skin
COSM4808151	c.8838C>G	p.P2946P	Substitution - coding silent	Pancreas
COSM1100907	c.8245C>A	p.L2749M	Substitution - Missense	Endometrium
COSM397894	c.3320C>T	p.A1107V	Substitution - Missense	Lung
COSM5442217	c.7348G>C	p.E2450Q	Substitution - Missense	Oesophagus
COSM5979533	c.8428T>A	p.F2810I	Substitution - Missense	Upper_aerodigestive_tract
COSM255543	c.5307delC	p.D1770fs*26	Deletion - Frameshift	Central_nervous_system
COSM4796063	c.3399G>A	p.T1133T	Substitution - coding silent	Liver
COSM1248223	c.3774C>G	p.I1258M	Substitution - Missense	Oesophagus
COSM3650066	c.1060C>T	p.P354S	Substitution - Missense	Skin
COSM3382279	c.3531A>G	p.K1177K	Substitution - coding silent	Pancreas
COSM751077	c.1245G>A	p.P415P	Substitution - coding silent	Lung
COSM3900886	c.8559G>A	p.E2853E	Substitution - coding silent	Stomach
COSM3650085	c.6786C>T	p.V2262V	Substitution - coding silent	Skin
COSM3900863	c.3627G>T	p.E1209D	Substitution - Missense	Stomach
COSM5620485	c.8297C>T	p.S2766L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4464072	c.1317C>T	p.P439P	Substitution - coding silent	Skin
COSM5067886	c.8955_8956insG	p.D2988fs*2	Insertion - Frameshift	Large_intestine
COSM255284	c.2368G>T	p.E790*	Substitution - Nonsense	Central_nervous_system
COSM1100870	c.7145C>T	p.T2382M	Substitution - Missense	Endometrium
COSM1100828	c.4974G>A	p.E1658E	Substitution - coding silent	Endometrium
COSM1319701	c.7199_7201delGGA	p.R2405delR	Deletion - In frame	Upper_aerodigestive_tract
COSM1457740	c.6773A>G	p.E2258G	Substitution - Missense	Large_intestine
COSM5596496	c.673C>T	p.P225S	Substitution - Missense	Skin
COSM3675144	c.337G>C	p.V113L	Substitution - Missense	Prostate
COSM2720111	c.5912A>C	p.E1971A	Substitution - Missense	Large_intestine
COSM3942706	c.8424C>T	p.N2808N	Substitution - coding silent	Oesophagus
COSM3716029	c.6163C>A	p.L2055M	Substitution - Missense	Upper_aerodigestive_tract
COSM5925410	c.664C>T	p.Q222*	Substitution - Nonsense	Skin
COSM4487080	c.3139C>T	p.H1047Y	Substitution - Missense	Skin
COSM5700588	c.1714C>G	p.Q572E	Substitution - Missense	Soft_tissue
COSM4950448	c.2666A>C	p.D889A	Substitution - Missense	Liver
COSM751035	c.7896C>T	p.N2632N	Substitution - coding silent	Lung
COSM360444	c.1072G>T	p.G358C	Substitution - Missense	Lung
COSM3650080	c.5945G>A	p.G1982E	Substitution - Missense	Skin
COSM3900876	c.6158G>A	p.R2053Q	Substitution - Missense	Oesophagus
COSM1100803	c.3398C>T	p.T1133M	Substitution - Missense	Endometrium
COSM4006946	c.1383T>A	p.F461L	Substitution - Missense	Urinary_tract
COSM4790088	c.1124A>G	p.Q375R	Substitution - Missense	Liver
COSM486561	c.2662A>T	p.M888L	Substitution - Missense	Kidney
COSM1730145	c.6403A>G	p.R2135G	Substitution - Missense	Liver
COSM2720051	c.3609A>G	p.E1203E	Substitution - coding silent	Upper_aerodigestive_tract
COSM4588162	c.6353A>G	p.N2118S	Substitution - Missense	Bone
COSM4803519	c.6087C>T	p.P2029P	Substitution - coding silent	Liver
COSM1187547	c.1234C>T	p.Q412*	Substitution - Nonsense	Lung
COSM5026920	c.2250C>T	p.S750S	Substitution - coding silent	Breast
COSM5590195	c.4058C>T	p.S1353F	Substitution - Missense	Skin
COSM1457755	c.8956delG	p.D2988fs*3	Deletion - Frameshift	Large_intestine
COSM1100785	c.1155G>A	p.Q385Q	Substitution - coding silent	Endometrium
COSM4442255	c.5539G>T	p.E1847*	Substitution - Nonsense	Large_intestine
COSM4556296	c.6874G>C	p.G2292R	Substitution - Missense	Skin
COSM2720128	c.6648T>C	p.N2216N	Substitution - coding silent	Bone
COSM4825583	c.3232C>T	p.H1078Y	Substitution - Missense	Upper_aerodigestive_tract
COSM3900870	c.4644+1G>A	p.?	Unknown	Stomach
COSM88107	c.2498+1G>A	p.?	Unknown	Central_nervous_system
COSM486559	c.2460G>T	p.E820D	Substitution - Missense	Kidney
COSM1457684	c.73G>A	p.G25R	Substitution - Missense	Large_intestine
COSM3650088	c.8717C>T	p.S2906F	Substitution - Missense	Skin
COSM5949818	c.5006C>T	p.T1669I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM301933	c.8268G>A	p.T2756T	Substitution - coding silent	Central_nervous_system
COSM5063275	c.2675G>A	p.R892H	Substitution - Missense	Stomach
COSM1158133	c.3208G>A	p.V1070M	Substitution - Missense	Pancreas
COSM3650072	c.3196C>T	p.P1066S	Substitution - Missense	Skin
COSM4977460	c.5478C>G	p.A1826A	Substitution - coding silent	Oesophagus
COSM5423007	c.5243T>C	p.L1748P	Substitution - Missense	Prostate
COSM1100821	c.4275C>T	p.F1425F	Substitution - coding silent	Endometrium
COSM5639842	c.4859G>A	p.R1620Q	Substitution - Missense	Oesophagus
COSM4187893	c.7988C>T	p.A2663V	Substitution - Missense	Kidney
COSM5067886	c.8955_8956insG	p.D2988fs*2	Insertion - Frameshift	Large_intestine
COSM4949522	c.4353G>C	p.G1451G	Substitution - coding silent	Liver
COSM4394334	c.4989C>T	p.F1663F	Substitution - coding silent	Skin
COSM1100791	c.2478C>A	p.F826L	Substitution - Missense	Endometrium
COSM1100834	c.5428C>T	p.R1810*	Substitution - Nonsense	Prostate
COSM3900849	c.257C>T	p.P86L	Substitution - Missense	Stomach
COSM3925440	c.2345C>T	p.S782F	Substitution - Missense	Skin
COSM4672085	c.2819C>T	p.P940L	Substitution - Missense	Large_intestine
COSM3650079	c.5533G>C	p.G1845R	Substitution - Missense	Skin
COSM3834874	c.7295T>G	p.V2432G	Substitution - Missense	Breast
COSM3663820	c.8439C>T	p.G2813G	Substitution - coding silent	Liver
COSM606052	c.7680C>A	p.P2560P	Substitution - coding silent	Skin
COSM3900884	c.8090A>G	p.E2697G	Substitution - Missense	Stomach
COSM422089	c.7369A>T	p.N2457Y	Substitution - Missense	Urinary_tract
COSM4498470	c.520C>T	p.P174S	Substitution - Missense	Skin
COSM5623549	c.4276G>A	p.D1426N	Substitution - Missense	Oesophagus
COSM3703415	c.1288A>G	p.M430V	Substitution - Missense	Liver
COSM4151537	c.5557G>A	p.E1853K	Substitution - Missense	Ovary
COSM751075	c.1375C>A	p.R459S	Substitution - Missense	Lung
COSM5518838	c.4125C>T	p.L1375L	Substitution - coding silent	Biliary_tract
COSM5723933	c.3764C>T	p.P1255L	Substitution - Missense	Skin
COSM4445212	c.995delT	p.L332fs*1	Deletion - Frameshift	Large_intestine
COSM1100901	c.7738C>T	p.L2580L	Substitution - coding silent	Endometrium
COSM5919503	c.6080G>A	p.R2027Q	Substitution - Missense	Skin
COSM4445219	c.3098G>T	p.R1033M	Substitution - Missense	Large_intestine
COSM5612096	c.2461G>T	p.V821L	Substitution - Missense	Adrenal_gland
COSM4546556	c.4022G>A	p.R1341K	Substitution - Missense	Skin
COSM1236485	c.8649G>T	p.L2883F	Substitution - Missense	Autonomic_ganglia
COSM301935	c.755C>T	p.S252L	Substitution - Missense	Central_nervous_system
COSM5409748	c.7856C>G	p.S2619*	Substitution - Nonsense	Skin
COSM5573805	c.5599_5600insA	p.I1868fs*3	Insertion - Frameshift	Prostate
COSM3367384	c.3685C>G	p.L1229V	Substitution - Missense	Kidney
COSM399250	c.1674G>T	p.P558P	Substitution - coding silent	Lung
COSM3951754	c.6715G>T	p.E2239*	Substitution - Nonsense	Lung
COSM3951756	c.7058C>A	p.T2353K	Substitution - Missense	Lung
COSM751059	c.4032C>A	p.L1344L	Substitution - coding silent	Lung
COSM1100767	c.258G>A	p.P86P	Substitution - coding silent	Endometrium
COSM1314136	c.3041G>A	p.G1014E	Substitution - Missense	Urinary_tract
COSM1489364	c.7756C>T	p.P2586S	Substitution - Missense	Breast
COSM1100800	c.2572C>T	p.R858*	Substitution - Nonsense	Endometrium
COSM2720035	c.3080C>T	p.T1027I	Substitution - Missense	Large_intestine
COSM1100861	c.6711C>T	p.S2237S	Substitution - coding silent	Endometrium

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
24211491	Mutation	Colorectal Carcinoma with CpG methylator phenotype 1	A prevalence screen showed that nonsilencing mutations in CHD7 and CHD8 occurred significantly more frequently in CIMP1 tumors (18 of 42 [43%]) than in CIMP2 (3 of 34 [9%]; P < .01) or CIMP-negative tumors (2 of 34 [6%]; P < .001).

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9P2D1	286	R	Asymmetric dimethylarginine	-	No	None detected
Q9P2D1	637	S	Phosphoserine	-	No	None detected
Q9P2D1	725	S	Phosphoserine	-	No	None detected
Q9P2D1	1577	S	Phosphoserine	-	No	None detected
Q9P2D1	1581	S	Phosphoserine	-	No	None detected
Q9P2D1	1874	S	Phosphoserine	-	Yes	p.S1874P (cancer: KIRC)
Q9P2D1	2231	S	Phosphoserine	-	No	None detected
Q9P2D1	2233	S	Phosphoserine	-	No	None detected
Q9P2D1	2237	S	Phosphoserine	-	Yes	p.S2237F (cancer: SKCM)
Q9P2D1	2251	S	Phosphoserine	-	No	None detected
Q9P2D1	2272	S	Phosphoserine	-	No	None detected
Q9P2D1	2275	S	Phosphoserine	-	No	None detected
Q9P2D1	2356	S	Phosphoserine	-	No	None detected
Q9P2D1	2395	S	Phosphoserine	-	No	None detected
Q9P2D1	2472	T	Phosphothreonine	-	No	None detected
Q9P2D1	2533	S	Phosphoserine	-	No	None detected
Q9P2D1	2535	S	Phosphoserine	-	No	None detected
Q9P2D1	2551	T	Phosphothreonine	-	No	None detected
Q9P2D1	2559	S	Phosphoserine	-	No	None detected
Q9P2D1	2619	S	Phosphoserine	-	No	None detected
Q9P2D1	2956	S	Phosphoserine	-	No	None detected
Q9P2D1	2961	S	Phosphoserine	-	No	None detected

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.48	5.077	0.674	0.00139	Over
BRCA	Breast invasive carcinoma	112	1100	5.011	5.178	0.12	0.302	NS
CESC	Cervical and endocervical cancers	3	306	3.264	4.831	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.037	5.851	0.924	3.12e-14	Over
ESCA	Esophageal carcinoma	11	185	5.197	5.859	0.55	0.0648	NS
GBM	Glioblastoma multiforme	5	166	4.693	5.295	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.83	4.808	-0.208	0.194	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.729	4.206	-0.415	2.74e-08	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.684	4.754	0.162	0.225	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.085	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.951	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.423	3.786	0.381	0.00372	NS
LUAD	Lung adenocarcinoma	59	517	4.523	4.939	0.479	0.000601	NS
LUSC	Lung squamous cell carcinoma	51	501	4.573	4.924	0.279	0.0631	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.042	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.741	4.929	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	3.658	4.627	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.193	4.348	0.125	0.274	NS
READ	Rectum adenocarcinoma	10	167	4.881	5.954	1.178	4.74e-05	Over
SARC	Sarcoma	2	263	3.221	3.045	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.175	5.515	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.048	5.903	1.024	7.49e-13	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.836	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.178	4.525	-0.588	1.69e-13	Under
THYM	Thymoma	2	120	4.117	3.794	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.187	5.336	1.248	3.85e-17	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.1
Autonomic ganglia	CHP212	8
Autonomic ganglia	IMR32	9.7
Autonomic ganglia	KELLY	9.2
Autonomic ganglia	KPNRTBM1	9.1
Autonomic ganglia	KPNSI9S	7.8
Autonomic ganglia	KPNYN	8.8
Autonomic ganglia	MHHNB11	8.8
Autonomic ganglia	NB1	9.1
Autonomic ganglia	NH6	7.7
Autonomic ganglia	SHSY5Y	8.7
Autonomic ganglia	SIMA	9.6
Autonomic ganglia	SKNAS	8.1
Autonomic ganglia	SKNBE2	8.9
Autonomic ganglia	SKNDZ	9.4
Autonomic ganglia	SKNFI	8.6
Autonomic ganglia	SKNSH	7.1
Biliary tract	HUCCT1	8
Biliary tract	HUH28	6.7
Biliary tract	SNU1079	7.8
Biliary tract	SNU1196	9
Biliary tract	SNU245	9.1
Biliary tract	SNU308	8.3
Biliary tract	SNU478	8
Bone	143B	8.8
Bone	A673	7
Bone	CADOES1	7.4
Bone	CAL78	4.4
Bone	G292CLONEA141B1	6.7
Bone	HOS	8.6
Bone	HS706T	5.7
Bone	HS737T	4.9
Bone	HS819T	4
Bone	HS821T	5.2
Bone	HS822T	4.8
Bone	HS863T	4.5
Bone	HS870T	4.9
Bone	HS888T	5
Bone	MG63	4.8
Bone	MHHES1	7.9
Bone	OUMS27	7.4
Bone	RDES	7
Bone	SJSA1	4.9
Bone	SKES1	5
Bone	SKNMC	4.5
Bone	SW1353	7.3
Bone	T173	4.5
Bone	TC71	5
Bone	U2OS	7.8
Breast	AU565	7.4
Breast	BT20	7.1
Breast	BT474	8.3
Breast	BT483	8.7
Breast	BT549	7.9
Breast	CAL120	7.9
Breast	CAL148	6.5
Breast	CAL51	8.5
Breast	CAL851	7.7
Breast	CAMA1	7.2
Breast	DU4475	8.2
Breast	EFM192A	6.1
Breast	EFM19	7.1
Breast	EVSAT	7.6
Breast	HCC1143	8.4
Breast	HCC1187	9
Breast	HCC1395	5.6
Breast	HCC1419	7.5
Breast	HCC1428	9.7
Breast	HCC1500	7.5
Breast	HCC1569	9
Breast	HCC1599	9.2
Breast	HCC1806	7.3
Breast	HCC1937	8.1
Breast	HCC1954	7.2
Breast	HCC202	7.6
Breast	HCC2157	9.2
Breast	HCC2218	8.5
Breast	HCC38	6.8
Breast	HCC70	7.9
Breast	HDQP1	7.7
Breast	HMC18	7.9
Breast	HS274T	4.5
Breast	HS281T	3.9
Breast	HS343T	4.5
Breast	HS578T	5.3
Breast	HS606T	4.6
Breast	HS739T	5.3
Breast	HS742T	4.7
Breast	JIMT1	8.6
Breast	KPL1	8.1
Breast	MCF7	8.5
Breast	MDAMB134VI	4.6
Breast	MDAMB157	7.2
Breast	MDAMB175VII	7.8
Breast	MDAMB231	7.1
Breast	MDAMB361	7.9
Breast	MDAMB415	7
Breast	MDAMB436	7.4
Breast	MDAMB453	6.7
Breast	MDAMB468	7.4
Breast	SKBR3	7.5
Breast	T47D	8
Breast	UACC812	8.8
Breast	UACC893	7.4
Breast	YMB1	7.6
Breast	ZR751	7.4
Breast	ZR7530	5.8
Central nervous system	1321N1	5.2
Central nervous system	42MGBA	4.6
Central nervous system	8MGBA	7.8
Central nervous system	A172	4.3
Central nervous system	AM38	7.8
Central nervous system	BECKER	4.6
Central nervous system	CAS1	6.1
Central nervous system	CCFSTTG1	4.4
Central nervous system	D283MED	9.2
Central nervous system	D341MED	9.4
Central nervous system	DAOY	7.8
Central nervous system	DBTRG05MG	5.9
Central nervous system	DKMG	6
Central nervous system	GAMG	6.6
Central nervous system	GB1	4.6
Central nervous system	GI1	7.8
Central nervous system	GMS10	7
Central nervous system	GOS3	5.3
Central nervous system	H4	7.3
Central nervous system	HS683	5.9
Central nervous system	KALS1	6.4
Central nervous system	KG1C	6.7
Central nervous system	KNS42	6.9
Central nervous system	KNS60	6.7
Central nervous system	KNS81	6.6
Central nervous system	KS1	6.3
Central nervous system	LN18	6.5
Central nervous system	LN229	7.5
Central nervous system	M059K	4.5
Central nervous system	MOGGCCM	6.8
Central nervous system	MOGGUVW	7.8
Central nervous system	NMCG1	6.4
Central nervous system	ONS76	7.3
Central nervous system	SF126	4.8
Central nervous system	SF295	4.2
Central nervous system	SNB19	5.8
Central nervous system	SNU1105	6.3
Central nervous system	SNU201	6.2
Central nervous system	SNU466	8.1
Central nervous system	SNU489	6.8
Central nervous system	SNU626	6.2
Central nervous system	SNU738	7.6
Central nervous system	SW1088	4.7
Central nervous system	SW1783	5.4
Central nervous system	T98G	5.2
Central nervous system	TM31	6.7
Central nervous system	U118MG	4.4
Central nervous system	U138MG	4.8
Central nervous system	U251MG	6.9
Central nervous system	U87MG	6.6
Central nervous system	YH13	4.6
Central nervous system	YKG1	7.3
Endometrium	AN3CA	7.4
Endometrium	COLO684	10.1
Endometrium	EFE184	8.5
Endometrium	EN	7.8
Endometrium	ESS1	7.3
Endometrium	HEC108	8.6
Endometrium	HEC151	8.4
Endometrium	HEC1A	8.3
Endometrium	HEC1B	8.1
Endometrium	HEC251	7.9
Endometrium	HEC265	8.1
Endometrium	HEC50B	8.6
Endometrium	HEC59	8
Endometrium	HEC6	8
Endometrium	ISHIKAWAHERAKLIO02ER	7.9
Endometrium	JHUEM1	7.9
Endometrium	JHUEM2	4.8
Endometrium	JHUEM3	7.2
Endometrium	KLE	6.2
Endometrium	MFE280	9.2
Endometrium	MFE296	5
Endometrium	MFE319	7.8
Endometrium	RL952	7.8
Endometrium	SNGM	8.4
Endometrium	SNU1077	8.2
Endometrium	SNU685	8.9
Endometrium	TEN	8.1
Haematopoietic and lymphoid	697	9.7
Haematopoietic and lymphoid	A3KAW	7.8
Haematopoietic and lymphoid	A4FUK	8.1
Haematopoietic and lymphoid	ALLSIL	6.4
Haematopoietic and lymphoid	AML193	6.7
Haematopoietic and lymphoid	AMO1	8.8
Haematopoietic and lymphoid	BCP1	8.2
Haematopoietic and lymphoid	BDCM	8
Haematopoietic and lymphoid	BL41	8.2
Haematopoietic and lymphoid	BL70	8.7
Haematopoietic and lymphoid	BV173	10.1
Haematopoietic and lymphoid	CA46	7.9
Haematopoietic and lymphoid	CI1	8.5
Haematopoietic and lymphoid	CMK115	8.8
Haematopoietic and lymphoid	CMK86	9.2
Haematopoietic and lymphoid	CMK	8.7
Haematopoietic and lymphoid	CMLT1	8.1
Haematopoietic and lymphoid	COLO775	8
Haematopoietic and lymphoid	DAUDI	8.8
Haematopoietic and lymphoid	DB	9.4
Haematopoietic and lymphoid	DEL	8
Haematopoietic and lymphoid	DND41	7.8
Haematopoietic and lymphoid	DOHH2	8.5
Haematopoietic and lymphoid	EB1	8.8
Haematopoietic and lymphoid	EB2	8.5
Haematopoietic and lymphoid	EHEB	8.1
Haematopoietic and lymphoid	EJM	8.6
Haematopoietic and lymphoid	EM2	8.9
Haematopoietic and lymphoid	EOL1	8.2
Haematopoietic and lymphoid	F36P	8.4
Haematopoietic and lymphoid	GA10	8.9
Haematopoietic and lymphoid	GDM1	8
Haematopoietic and lymphoid	GRANTA519	8.3
Haematopoietic and lymphoid	HDLM2	7.3
Haematopoietic and lymphoid	HDMYZ	5.8
Haematopoietic and lymphoid	HEL9217	9.2
Haematopoietic and lymphoid	HEL	9.1
Haematopoietic and lymphoid	HH	8.6
Haematopoietic and lymphoid	HL60	9
Haematopoietic and lymphoid	HPBALL	7.8
Haematopoietic and lymphoid	HS604T	6.2
Haematopoietic and lymphoid	HS611T	8.8
Haematopoietic and lymphoid	HS616T	4.3
Haematopoietic and lymphoid	HS751T	4.9
Haematopoietic and lymphoid	HT	7.3
Haematopoietic and lymphoid	HTK	9.4
Haematopoietic and lymphoid	HUNS1	8.8
Haematopoietic and lymphoid	HUT102	6.8
Haematopoietic and lymphoid	HUT78	8.2
Haematopoietic and lymphoid	JEKO1	7.8
Haematopoietic and lymphoid	JK1	8.8
Haematopoietic and lymphoid	JM1	9
Haematopoietic and lymphoid	JURKAT	8.7
Haematopoietic and lymphoid	JURLMK1	8.6
Haematopoietic and lymphoid	JVM2	7.6
Haematopoietic and lymphoid	JVM3	8
Haematopoietic and lymphoid	K562	8
Haematopoietic and lymphoid	KARPAS299	8.1
Haematopoietic and lymphoid	KARPAS422	8.7
Haematopoietic and lymphoid	KARPAS620	9.3
Haematopoietic and lymphoid	KASUMI1	8
Haematopoietic and lymphoid	KASUMI2	9.6
Haematopoietic and lymphoid	KASUMI6	4.4
Haematopoietic and lymphoid	KCL22	8
Haematopoietic and lymphoid	KE37	8.6
Haematopoietic and lymphoid	KE97	8.2
Haematopoietic and lymphoid	KG1	5.9
Haematopoietic and lymphoid	KHM1B	8.6
Haematopoietic and lymphoid	KIJK	7.7
Haematopoietic and lymphoid	KMH2	8.4
Haematopoietic and lymphoid	KMM1	9.1
Haematopoietic and lymphoid	KMS11	9.9
Haematopoietic and lymphoid	KMS12BM	9.3
Haematopoietic and lymphoid	KMS18	8.4
Haematopoietic and lymphoid	KMS20	8.3
Haematopoietic and lymphoid	KMS21BM	7.7
Haematopoietic and lymphoid	KMS26	9.2
Haematopoietic and lymphoid	KMS27	7.3
Haematopoietic and lymphoid	KMS28BM	9
Haematopoietic and lymphoid	KMS34	8.6
Haematopoietic and lymphoid	KO52	8
Haematopoietic and lymphoid	KOPN8	8.6
Haematopoietic and lymphoid	KU812	9.7
Haematopoietic and lymphoid	KYO1	8.6
Haematopoietic and lymphoid	L1236	6.9
Haematopoietic and lymphoid	L363	9.7
Haematopoietic and lymphoid	L428	8.1
Haematopoietic and lymphoid	L540	8.1
Haematopoietic and lymphoid	LAMA84	9
Haematopoietic and lymphoid	LOUCY	8.6
Haematopoietic and lymphoid	LP1	8.9
Haematopoietic and lymphoid	M07E	8.8
Haematopoietic and lymphoid	MC116	8.4
Haematopoietic and lymphoid	ME1	8.5
Haematopoietic and lymphoid	MEC1	8.6
Haematopoietic and lymphoid	MEC2	8.6
Haematopoietic and lymphoid	MEG01	9.4
Haematopoietic and lymphoid	MHHCALL2	9.2
Haematopoietic and lymphoid	MHHCALL3	9.3
Haematopoietic and lymphoid	MHHCALL4	9.3
Haematopoietic and lymphoid	MINO	8.9
Haematopoietic and lymphoid	MJ	7.9
Haematopoietic and lymphoid	MM1S	7.8
Haematopoietic and lymphoid	MOLM13	8.2
Haematopoietic and lymphoid	MOLM16	8.9
Haematopoietic and lymphoid	MOLM6	8.1
Haematopoietic and lymphoid	MOLP2	8.1
Haematopoietic and lymphoid	MOLP8	9.4
Haematopoietic and lymphoid	MOLT13	7.2
Haematopoietic and lymphoid	MOLT16	6.5
Haematopoietic and lymphoid	MOLT4	8.6
Haematopoietic and lymphoid	MONOMAC1	7.7
Haematopoietic and lymphoid	MONOMAC6	8.1
Haematopoietic and lymphoid	MOTN1	4.6
Haematopoietic and lymphoid	MUTZ5	8.1
Haematopoietic and lymphoid	MV411	7.6
Haematopoietic and lymphoid	NALM19	9.2
Haematopoietic and lymphoid	NALM1	9.3
Haematopoietic and lymphoid	NALM6	9.8
Haematopoietic and lymphoid	NAMALWA	9.9
Haematopoietic and lymphoid	NB4	8.3
Haematopoietic and lymphoid	NCIH929	7.6
Haematopoietic and lymphoid	NCO2	8.3
Haematopoietic and lymphoid	NOMO1	8.6
Haematopoietic and lymphoid	NUDHL1	8.9
Haematopoietic and lymphoid	NUDUL1	9.7
Haematopoietic and lymphoid	OCIAML2	7.9
Haematopoietic and lymphoid	OCIAML3	8.2
Haematopoietic and lymphoid	OCIAML5	8.9
Haematopoietic and lymphoid	OCILY10	8.7
Haematopoietic and lymphoid	OCILY19	9.3
Haematopoietic and lymphoid	OCILY3	7.2
Haematopoietic and lymphoid	OCIM1	8
Haematopoietic and lymphoid	OPM2	9.2
Haematopoietic and lymphoid	P12ICHIKAWA	8.2
Haematopoietic and lymphoid	P31FUJ	6.5
Haematopoietic and lymphoid	P3HR1	9
Haematopoietic and lymphoid	PCM6	8.6
Haematopoietic and lymphoid	PEER	8.3
Haematopoietic and lymphoid	PF382	7.1
Haematopoietic and lymphoid	PFEIFFER	6.9
Haematopoietic and lymphoid	PL21	6.2
Haematopoietic and lymphoid	RAJI	8.4
Haematopoietic and lymphoid	RCHACV	9.4
Haematopoietic and lymphoid	REC1	9.4
Haematopoietic and lymphoid	REH	9.7
Haematopoietic and lymphoid	RI1	8.2
Haematopoietic and lymphoid	RL	8.6
Haematopoietic and lymphoid	RPMI8226	7.9
Haematopoietic and lymphoid	RPMI8402	5.8
Haematopoietic and lymphoid	RS411	9.4
Haematopoietic and lymphoid	SEM	8.8
Haematopoietic and lymphoid	SET2	8.5
Haematopoietic and lymphoid	SIGM5	8.4
Haematopoietic and lymphoid	SKM1	8.8
Haematopoietic and lymphoid	SKMM2	8
Haematopoietic and lymphoid	SR786	8.6
Haematopoietic and lymphoid	ST486	7.9
Haematopoietic and lymphoid	SUDHL10	7.3
Haematopoietic and lymphoid	SUDHL1	9.2
Haematopoietic and lymphoid	SUDHL4	9.3
Haematopoietic and lymphoid	SUDHL5	8.1
Haematopoietic and lymphoid	SUDHL6	8.9
Haematopoietic and lymphoid	SUDHL8	8.6
Haematopoietic and lymphoid	SUPB15	9.6
Haematopoietic and lymphoid	SUPHD1	9.1
Haematopoietic and lymphoid	SUPM2	6.9
Haematopoietic and lymphoid	SUPT11	7.3
Haematopoietic and lymphoid	SUPT1	7.9
Haematopoietic and lymphoid	TALL1	8
Haematopoietic and lymphoid	TF1	9.2
Haematopoietic and lymphoid	THP1	7.8
Haematopoietic and lymphoid	TO175T	4.8
Haematopoietic and lymphoid	TOLEDO	8.8
Haematopoietic and lymphoid	U266B1	8.5
Haematopoietic and lymphoid	U937	4.5
Haematopoietic and lymphoid	UT7	8.3
Haematopoietic and lymphoid	WSUDLCL2	8.1
Kidney	769P	8.2
Kidney	786O	8
Kidney	A498	6.3
Kidney	A704	6.9
Kidney	ACHN	6.6
Kidney	BFTC909	7.8
Kidney	CAKI1	7.1
Kidney	CAKI2	5.6
Kidney	CAL54	8.3
Kidney	KMRC1	6.8
Kidney	KMRC20	7.2
Kidney	KMRC2	7.2
Kidney	KMRC3	6.4
Kidney	OSRC2	6.7
Kidney	RCC10RGB	7.5
Kidney	SNU1272	7.1
Kidney	SNU349	5.5
Kidney	TUHR10TKB	7.3
Kidney	TUHR14TKB	7.4
Kidney	TUHR4TKB	6.9
Kidney	VMRCRCW	7
Kidney	VMRCRCZ	7.6
Large intestine	C2BBE1	8.5
Large intestine	CCK81	8.8
Large intestine	CL11	8.8
Large intestine	CL14	8.2
Large intestine	CL34	8.4
Large intestine	CL40	8
Large intestine	COLO205	8.1
Large intestine	COLO320	9.1
Large intestine	COLO678	8.3
Large intestine	CW2	7.6
Large intestine	DLD1	8.2
Large intestine	GP2D	8.9
Large intestine	HCC56	8.6
Large intestine	HCT116	8
Large intestine	HCT15	8.4
Large intestine	HS675T	4.9
Large intestine	HS698T	4.8
Large intestine	HT115	8.1
Large intestine	HT29	8.7
Large intestine	HT55	8.5
Large intestine	KM12	8
Large intestine	LOVO	8.1
Large intestine	LS1034	8.4
Large intestine	LS123	7.6
Large intestine	LS180	8.3
Large intestine	LS411N	8.1
Large intestine	LS513	8
Large intestine	MDST8	6.2
Large intestine	NCIH508	8.3
Large intestine	NCIH716	7.9
Large intestine	NCIH747	8.1
Large intestine	OUMS23	8.9
Large intestine	RCM1	8
Large intestine	RKO	8.2
Large intestine	SKCO1	8.7
Large intestine	SNU1040	8.2
Large intestine	SNU1197	7.9
Large intestine	SNU175	8
Large intestine	SNU283	8.5
Large intestine	SNU407	7.9
Large intestine	SNU503	8
Large intestine	SNU61	7.8
Large intestine	SNU81	8.4
Large intestine	SNUC1	8.6
Large intestine	SNUC2A	7.6
Large intestine	SNUC4	8.5
Large intestine	SNUC5	7.9
Large intestine	SW1116	8.7
Large intestine	SW1417	7.4
Large intestine	SW1463	9.4
Large intestine	SW403	8.7
Large intestine	SW480	7
Large intestine	SW48	8.5
Large intestine	SW620	8.6
Large intestine	SW837	8.3
Large intestine	SW948	8.4
Large intestine	T84	8.2
Liver	ALEXANDERCELLS	7.2
Liver	C3A	8.1
Liver	HEP3B217	8.7
Liver	HEPG2	8.5
Liver	HLE	6.7
Liver	HLF	7
Liver	HUH1	7.7
Liver	HUH6	9.4
Liver	HUH7	9
Liver	JHH1	8.2
Liver	JHH2	7.9
Liver	JHH4	8
Liver	JHH5	8.9
Liver	JHH6	6.8
Liver	JHH7	8.1
Liver	LI7	7.7
Liver	PLCPRF5	7.7
Liver	SKHEP1	7.1
Liver	SNU182	7.1
Liver	SNU387	6.5
Liver	SNU398	8.7
Liver	SNU423	6.3
Liver	SNU449	8
Liver	SNU475	7.8
Liver	SNU761	6.1
Liver	SNU878	6.7
Liver	SNU886	7.3
Lung	A549	6.9
Lung	ABC1	8
Lung	BEN	8.3
Lung	CAL12T	8
Lung	CALU1	6.1
Lung	CALU3	7.4
Lung	CALU6	8.9
Lung	CHAGOK1	6.3
Lung	COLO668	8.8
Lung	COLO699	8
Lung	CORL105	6.9
Lung	CORL23	8.1
Lung	CORL24	9.6
Lung	CORL279	10.2
Lung	CORL311	8.5
Lung	CORL47	8.7
Lung	CORL51	9.9
Lung	CORL88	9.9
Lung	CORL95	8.9
Lung	CPCN	8.8
Lung	DMS114	8.4
Lung	DMS153	9.5
Lung	DMS273	8.3
Lung	DMS454	8.9
Lung	DMS53	8.5
Lung	DMS79	8.5
Lung	DV90	8.4
Lung	EBC1	8.4
Lung	EPLC272H	8.1
Lung	HARA	7
Lung	HCC1171	8.3
Lung	HCC1195	7.2
Lung	HCC15	7.5
Lung	HCC2279	7
Lung	HCC2935	6.4
Lung	HCC33	9.9
Lung	HCC366	7.4
Lung	HCC4006	7.1
Lung	HCC44	8.3
Lung	HCC78	7.2
Lung	HCC827	9.4
Lung	HCC95	7.1
Lung	HLC1	6.5
Lung	HLFA	4.6
Lung	HS229T	4.7
Lung	HS618T	4.2
Lung	IALM	7.9
Lung	KNS62	7.6
Lung	LC1F	7.5
Lung	LC1SQSF	6.2
Lung	LCLC103H	7.6
Lung	LCLC97TM1	8.5
Lung	LK2	9.4
Lung	LOUNH91	6.3
Lung	LU65	7.9
Lung	LU99	8.2
Lung	LUDLU1	7.6
Lung	LXF289	7.9
Lung	MORCPR	8.9
Lung	NCIH1048	7.9
Lung	NCIH1092	9.5
Lung	NCIH1105	10.3
Lung	NCIH1155	9.5
Lung	NCIH1184	9.4
Lung	NCIH1299	8.7
Lung	NCIH1339	8.4
Lung	NCIH1341	7.9
Lung	NCIH1355	7.6
Lung	NCIH1373	7.2
Lung	NCIH1385	8.7
Lung	NCIH1395	8.1
Lung	NCIH1435	9.2
Lung	NCIH1436	9.8
Lung	NCIH1437	7.6
Lung	NCIH146	9.5
Lung	NCIH1563	7.3
Lung	NCIH1568	8.4
Lung	NCIH1573	7.2
Lung	NCIH1581	8.9
Lung	NCIH1618	9.2
Lung	NCIH1623	8.5
Lung	NCIH1648	8
Lung	NCIH1650	7.8
Lung	NCIH1651	7.7
Lung	NCIH1666	8.6
Lung	NCIH1693	8
Lung	NCIH1694	8.6
Lung	NCIH1703	6.8
Lung	NCIH1734	8.3
Lung	NCIH1755	8
Lung	NCIH1781	5.3
Lung	NCIH1792	7.9
Lung	NCIH1793	7.4
Lung	NCIH1836	9.3
Lung	NCIH1838	8
Lung	NCIH1869	7.2
Lung	NCIH1876	9.7
Lung	NCIH1915	7.4
Lung	NCIH1930	10.3
Lung	NCIH1944	8.3
Lung	NCIH1963	9.8
Lung	NCIH196	4.6
Lung	NCIH1975	6.7
Lung	NCIH2009	8.3
Lung	NCIH2023	7.7
Lung	NCIH2029	9.4
Lung	NCIH2030	7.7
Lung	NCIH2066	9.5
Lung	NCIH2081	9.9
Lung	NCIH2085	8.4
Lung	NCIH2087	8.1
Lung	NCIH209	9.8
Lung	NCIH2106	7.9
Lung	NCIH2110	8.3
Lung	NCIH211	7.4
Lung	NCIH2122	8.4
Lung	NCIH2126	7.6
Lung	NCIH2141	10.1
Lung	NCIH2170	8.7
Lung	NCIH2171	11.4
Lung	NCIH2172	7.5
Lung	NCIH2196	8.6
Lung	NCIH2227	8.6
Lung	NCIH2228	6.5
Lung	NCIH226	7.1
Lung	NCIH2286	8.1
Lung	NCIH2291	7.4
Lung	NCIH2342	7.2
Lung	NCIH2347	7.2
Lung	NCIH23	7.5
Lung	NCIH2405	7.6
Lung	NCIH2444	8.1
Lung	NCIH292	7.8
Lung	NCIH322	7.9
Lung	NCIH3255	7.7
Lung	NCIH358	8.2
Lung	NCIH441	8
Lung	NCIH446	8.5
Lung	NCIH460	7.3
Lung	NCIH510	8.3
Lung	NCIH520	8.1
Lung	NCIH522	7.5
Lung	NCIH524	9.5
Lung	NCIH526	8.9
Lung	NCIH596	7.2
Lung	NCIH647	8.3
Lung	NCIH650	6.8
Lung	NCIH661	7.8
Lung	NCIH69	10.1
Lung	NCIH727	8.8
Lung	NCIH810	10.5
Lung	NCIH82	10
Lung	NCIH838	7.9
Lung	NCIH841	8
Lung	NCIH854	8.9
Lung	NCIH889	9.9
Lung	PC14	6.6
Lung	RERFLCAD1	7.9
Lung	RERFLCAD2	8.2
Lung	RERFLCAI	7.7
Lung	RERFLCKJ	7
Lung	RERFLCMS	6.7
Lung	RERFLCSQ1	7.5
Lung	SBC5	8.1
Lung	SCLC21H	9.1
Lung	SHP77	10
Lung	SKLU1	6.9
Lung	SKMES1	7.1
Lung	SQ1	7
Lung	SW1271	7.3
Lung	SW1573	7.5
Lung	SW900	7.9
Lung	VMRCLCD	9.6
Lung	VMRCLCP	8
Oesophagus	COLO680N	8
Oesophagus	ECGI10	6.3
Oesophagus	KYSE140	7
Oesophagus	KYSE150	7.4
Oesophagus	KYSE180	8.3
Oesophagus	KYSE270	9.3
Oesophagus	KYSE30	7.9
Oesophagus	KYSE410	7.8
Oesophagus	KYSE450	7.3
Oesophagus	KYSE510	7.6
Oesophagus	KYSE520	7.4
Oesophagus	KYSE70	5.8
Oesophagus	OE19	8.2
Oesophagus	OE33	7.8
Oesophagus	TE10	7.7
Oesophagus	TE11	6.6
Oesophagus	TE14	7.8
Oesophagus	TE15	6.8
Oesophagus	TE1	7.6
Oesophagus	TE4	7.2
Oesophagus	TE5	7
Oesophagus	TE6	8.9
Oesophagus	TE8	7.8
Oesophagus	TE9	7.2
Oesophagus	TT	7.8
Ovary	59M	7.6
Ovary	A2780	8.7
Ovary	CAOV3	7.5
Ovary	CAOV4	8
Ovary	COLO704	9.5
Ovary	COV318	7.9
Ovary	COV362	6.5
Ovary	COV434	7.3
Ovary	COV504	7.2
Ovary	COV644	7.4
Ovary	EFO21	5.1
Ovary	EFO27	7.8
Ovary	ES2	7.9
Ovary	FUOV1	5.6
Ovary	HEYA8	7.7
Ovary	HS571T	5.2
Ovary	IGROV1	8.5
Ovary	JHOC5	7.9
Ovary	JHOM1	7.3
Ovary	JHOM2B	8.4
Ovary	JHOS2	7.7
Ovary	JHOS4	7.6
Ovary	KURAMOCHI	9.6
Ovary	MCAS	7.6
Ovary	NIHOVCAR3	8.2
Ovary	OAW28	7.4
Ovary	OAW42	5.3
Ovary	OC314	8.1
Ovary	OC316	7.8
Ovary	ONCODG1	8
Ovary	OV56	7.7
Ovary	OV7	6.2
Ovary	OV90	7.8
Ovary	OVCAR4	8.5
Ovary	OVCAR8	7.6
Ovary	OVISE	8.3
Ovary	OVK18	7.8
Ovary	OVKATE	6.5
Ovary	OVMANA	8.4
Ovary	OVSAHO	7
Ovary	OVTOKO	7.6
Ovary	RMGI	6.9
Ovary	RMUGS	7.3
Ovary	SKOV3	7.4
Ovary	SNU119	7.5
Ovary	SNU840	8.4
Ovary	SNU8	7.7
Ovary	TOV112D	8.2
Ovary	TOV21G	7.6
Ovary	TYKNU	7.6
Pancreas	ASPC1	8.3
Pancreas	BXPC3	7.8
Pancreas	CAPAN1	8.3
Pancreas	CAPAN2	8.2
Pancreas	CFPAC1	7.9
Pancreas	DANG	7.7
Pancreas	HPAC	9
Pancreas	HPAFII	8
Pancreas	HS766T	7.1
Pancreas	HUPT3	7.2
Pancreas	HUPT4	7
Pancreas	KCIMOH1	8.4
Pancreas	KLM1	7.3
Pancreas	KP2	7
Pancreas	KP3	7.2
Pancreas	KP4	6.6
Pancreas	L33	8
Pancreas	MIAPACA2	6.5
Pancreas	PANC0203	8
Pancreas	PANC0213	8.1
Pancreas	PANC0327	8
Pancreas	PANC0403	7.6
Pancreas	PANC0504	7.6
Pancreas	PANC0813	8.7
Pancreas	PANC1005	8.5
Pancreas	PANC1	7.5
Pancreas	PATU8902	8.3
Pancreas	PATU8988S	8.4
Pancreas	PATU8988T	7.8
Pancreas	PK1	8.1
Pancreas	PK45H	6.7
Pancreas	PK59	7.3
Pancreas	PL45	7.9
Pancreas	PSN1	7.6
Pancreas	QGP1	8
Pancreas	SNU213	8.7
Pancreas	SNU324	7.5
Pancreas	SNU410	7.7
Pancreas	SU8686	7.9
Pancreas	SUIT2	7.3
Pancreas	SW1990	7.4
Pancreas	T3M4	8.2
Pancreas	TCCPAN2	6.9
Pancreas	YAPC	8.6
Pleura	ACCMESO1	6.6
Pleura	DM3	4.4
Pleura	ISTMES1	6.3
Pleura	ISTMES2	7.3
Pleura	JL1	7.1
Pleura	MPP89	7.1
Pleura	MSTO211H	7.7
Pleura	NCIH2052	7.6
Pleura	NCIH2452	6.9
Pleura	NCIH28	7.4
Prostate	22RV1	7.2
Prostate	DU145	7.2
Prostate	LNCAPCLONEFGC	6.6
Prostate	MDAPCA2B	7.1
Prostate	NCIH660	8.4
Prostate	PC3	6.1
Prostate	VCAP	7.4
Salivary gland	A253	7.5
Salivary gland	YD15	8.6
Skin	A101D	6.9
Skin	A2058	8.6
Skin	A375	7.9
Skin	C32	7.6
Skin	CHL1	8.4
Skin	CJM	8
Skin	COLO679	8.3
Skin	COLO741	8.4
Skin	COLO783	8.4
Skin	COLO792	8
Skin	COLO800	8.2
Skin	COLO818	7.8
Skin	COLO829	7.4
Skin	COLO849	8.5
Skin	G361	8.9
Skin	GRM	7.6
Skin	HMCB	8.2
Skin	HS294T	6.6
Skin	HS600T	4.5
Skin	HS688AT	4.5
Skin	HS695T	8
Skin	HS839T	4.5
Skin	HS852T	8.2
Skin	HS895T	4.7
Skin	HS934T	4.2
Skin	HS936T	8
Skin	HS939T	7.8
Skin	HS940T	5.7
Skin	HS944T	6.5
Skin	HT144	8.1
Skin	IGR1	8.3
Skin	IGR37	8.2
Skin	IGR39	7.3
Skin	IPC298	8.2
Skin	K029AX	8.2
Skin	LOXIMVI	8.7
Skin	MALME3M	7.8
Skin	MDAMB435S	7.6
Skin	MELHO	8.4
Skin	MELJUSO	7.5
Skin	MEWO	8.4
Skin	RPMI7951	6.9
Skin	RVH421	7.8
Skin	SH4	8.7
Skin	SKMEL1	8.2
Skin	SKMEL24	8.1
Skin	SKMEL28	8
Skin	SKMEL2	8.3
Skin	SKMEL30	8.2
Skin	SKMEL31	7.6
Skin	SKMEL3	8.4
Skin	SKMEL5	8.4
Skin	UACC257	7.9
Skin	UACC62	8.3
Skin	WM115	8.2
Skin	WM1799	8.5
Skin	WM2664	8
Skin	WM793	8
Skin	WM88	7.7
Skin	WM983B	8.2
Small intestine	HUTU80	8.6
Soft tissue	A204	4.3
Soft tissue	G401	4.4
Soft tissue	G402	4.6
Soft tissue	GCT	7.9
Soft tissue	HS729	5.4
Soft tissue	HT1080	7.5
Soft tissue	KYM1	4.7
Soft tissue	MESSA	8
Soft tissue	RD	9.1
Soft tissue	RH30	8
Soft tissue	RH41	9.9
Soft tissue	RKN	6.1
Soft tissue	S117	7.2
Soft tissue	SJRH30	9.5
Soft tissue	SKLMS1	6
Soft tissue	SKUT1	7.7
Soft tissue	TE125T	4.6
Soft tissue	TE159T	4.4
Soft tissue	TE441T	10.3
Soft tissue	TE617T	7.8
Stomach	2313287	7.5
Stomach	AGS	8.6
Stomach	AZ521	8.2
Stomach	ECC10	10.4
Stomach	ECC12	10.2
Stomach	FU97	8.4
Stomach	GCIY	7.5
Stomach	GSS	8.7
Stomach	GSU	8.3
Stomach	HGC27	7.6
Stomach	HS746T	5.9
Stomach	HUG1N	7.2
Stomach	IM95	8.3
Stomach	KATOIII	7.8
Stomach	KE39	8.5
Stomach	LMSU	7.3
Stomach	MKN1	7.2
Stomach	MKN45	7.7
Stomach	MKN74	7.8
Stomach	MKN7	6.7
Stomach	NCCSTCK140	8.9
Stomach	NCIN87	7.6
Stomach	NUGC2	5.2
Stomach	NUGC3	7.1
Stomach	NUGC4	8.3
Stomach	OCUM1	8.8
Stomach	RERFGC1B	8.2
Stomach	SH10TC	8.1
Stomach	SNU16	8.3
Stomach	SNU1	8.6
Stomach	SNU216	8.6
Stomach	SNU520	8.1
Stomach	SNU5	7.9
Stomach	SNU601	8.5
Stomach	SNU620	8.6
Stomach	SNU668	9.3
Stomach	SNU719	8.1
Stomach	TGBC11TKB	8.6
Thyroid	8305C	7.2
Thyroid	8505C	7.8
Thyroid	BCPAP	7.3
Thyroid	BHT101	10
Thyroid	CAL62	8.5
Thyroid	CGTHW1	6.3
Thyroid	FTC133	4.3
Thyroid	FTC238	6.9
Thyroid	ML1	7.6
Thyroid	SW579	6.3
Thyroid	TT2609C02	6.9
Thyroid	TT	9.4
Upper aerodigestive tract	BHY	8.4
Upper aerodigestive tract	BICR16	6.8
Upper aerodigestive tract	BICR18	7.3
Upper aerodigestive tract	BICR22	7.4
Upper aerodigestive tract	BICR31	7
Upper aerodigestive tract	BICR56	8.4
Upper aerodigestive tract	BICR6	7.9
Upper aerodigestive tract	CAL27	7.1
Upper aerodigestive tract	CAL33	7.7
Upper aerodigestive tract	DETROIT562	7.1
Upper aerodigestive tract	FADU	7.9
Upper aerodigestive tract	HS840T	4.7
Upper aerodigestive tract	HSC2	7.4
Upper aerodigestive tract	HSC3	7
Upper aerodigestive tract	HSC4	8.1
Upper aerodigestive tract	PECAPJ15	7.8
Upper aerodigestive tract	PECAPJ34CLONEC12	7.4
Upper aerodigestive tract	PECAPJ41CLONED2	7.7
Upper aerodigestive tract	PECAPJ49	7.7
Upper aerodigestive tract	SCC15	7.5
Upper aerodigestive tract	SCC25	6.8
Upper aerodigestive tract	SCC4	8.2
Upper aerodigestive tract	SCC9	8.4
Upper aerodigestive tract	SNU1076	6.8
Upper aerodigestive tract	SNU1214	7.2
Upper aerodigestive tract	SNU46	7.8
Upper aerodigestive tract	SNU899	7.8
Upper aerodigestive tract	YD10B	7.7
Upper aerodigestive tract	YD38	8.6
Upper aerodigestive tract	YD8	7.1
Urinary tract	5637	7.6
Urinary tract	639V	8.5
Urinary tract	647V	7.9
Urinary tract	BC3C	8
Urinary tract	BFTC905	8
Urinary tract	CAL29	6.6
Urinary tract	HS172T	4.9
Urinary tract	HT1197	6.7
Urinary tract	HT1376	8
Urinary tract	J82	7.5
Urinary tract	JMSU1	8.4
Urinary tract	KMBC2	8.2
Urinary tract	KU1919	8
Urinary tract	RT11284	8.1
Urinary tract	RT112	7.1
Urinary tract	RT4	7.7
Urinary tract	SCABER	8.2
Urinary tract	SW1710	7.7
Urinary tract	SW780	8
Urinary tract	T24	6.8
Urinary tract	TCCSUP	6.6
Urinary tract	UMUC1	7.7
Urinary tract	UMUC3	8.1
Urinary tract	VMCUB1	8.6

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	3.5
Adrenal gland	2.1
Appendix	5.3
Bone marrow	14.4
Breast	4
Cerebral cortex	10.9
Cervix, uterine	2.4
Colon	4
Duodenum	4.7
Endometrium	3.1
Epididymis	2.9
Esophagus	2.9
Fallopian tube	3.8
Gallbladder	3
Heart muscle	2.2
Kidney	2.8
Liver	1.4
Lung	4.5
Lymph node	6.9
Ovary	1.1
Pancreas	0.7
Parathyroid gland	14.6
Placenta	6.3
Prostate	3.1
Rectum	4.6
Salivary gland	1.7
Seminal vesicle	2.5
Skeletal muscle	1.4
Skin	5.3
Small intestine	4.6
Smooth muscle	2.7
Spleen	6.2
Stomach	3.3
Testis	5.6
Thyroid gland	6.8
Tonsil	5.6
Urinary bladder	2.7

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
12124339	Overexpression	Colon Carcinoma	KNSL6 and KIAA1416, were up-regulated, and another antigen, NY-CO-45, showed a variable level of mRNA expression in colon cancer.

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.38	2.37e-15	9.2	38.6	52.2	Gain
BRCA	Breast invasive carcinoma	1075	0.378	8.3e-38	6	42	51.9	Gain
CESC	Cervical and endocervical cancers	292	0.278	1.35e-06	7.5	61.6	30.8	Neutral
COAD	Colon adenocarcinoma	449	0.398	1.7e-18	3.3	44.1	52.6	Gain
ESCA	Esophageal carcinoma	183	0.333	3.97e-06	9.8	34.4	55.7	Gain
GBM	Glioblastoma multiforme	147	0.202	0.0142	11.6	76.9	11.6	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.229	1.48e-07	5.1	34.4	60.5	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.246	1.05e-08	14.1	73.9	12	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.156	0.00788	3.5	88.9	7.6	Neutral
LAML	Acute Myeloid Leukemia	166	0.081	0.298	0	88.6	11.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.261	1.91e-09	2.5	88.1	9.4	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.482	1.47e-22	10.2	41.8	48.1	Gain
LUAD	Lung adenocarcinoma	512	0.483	2.92e-31	10.2	41.4	48.4	Gain
LUSC	Lung squamous cell carcinoma	498	0.304	4.25e-12	12.7	35.5	51.8	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.387	3.54e-12	12.7	32.7	54.7	Gain
PAAD	Pancreatic adenocarcinoma	177	0.508	5.17e-13	9	65	26	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.293	0.000152	7.4	84.6	8	Neutral
PRAD	Prostate adenocarcinoma	491	0.237	1.07e-07	5.9	69	25.1	Neutral
READ	Rectum adenocarcinoma	164	0.462	4.85e-10	5.5	38.4	56.1	Gain
SARC	Sarcoma	255	0.229	0.000221	12.5	56.1	31.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.243	2.37e-06	7.9	45.5	46.6	Gain
STAD	Stomach adenocarcinoma	413	0.555	8.88e-35	9.4	35.8	54.7	Gain
TGCT	Testicular Germ Cell Tumors	150	0.174	0.0336	2.7	16	81.3	Gain
THCA	Thyroid carcinoma	497	0.057	0.207	0.8	97.8	1.4	Neutral
THYM	Thymoma	119	0.185	0.0442	1.7	89.9	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.372	4.37e-19	2.6	65.4	32	Neutral

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.523	0	17	408	-0.263	2.43e-07	Decreased
BRCA	Breast invasive carcinoma	-0.506	0	83	785	0.08	0.0245	NS/NA
CESC	Cervical and endocervical cancers	-0.554	0	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.467	0	19	297	-0.008	0.0197	NS/NA
ESCA	Esophageal carcinoma	-0.524	0	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.645	1.57e-08	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.3	1.33e-12	20	522	0.004	0.765	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.256	1.72e-06	24	319	0.006	0.139	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.512	0	23	275	-0.139	0.00235	NS/NA
LAML	Acute Myeloid Leukemia	-0.451	1.03e-09	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.54	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.344	7.69e-13	41	373	0.008	0.00381	NS/NA
LUAD	Lung adenocarcinoma	-0.475	0	21	456	0.078	0.001	NS/NA
LUSC	Lung squamous cell carcinoma	-0.441	0	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.7	0.0433	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.255	0.000513	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.416	4.48e-09	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.236	3.9e-08	35	498	0.001	0.0607	NS/NA
READ	Rectum adenocarcinoma	-0.492	2.57e-07	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.224	0.000253	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.467	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.477	0	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.57	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.406	0	50	509	0.101	0.00137	NS/NA
THYM	Thymoma	-0.465	9.82e-08	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.538	0	34	431	-0.335	4.05e-53	Decreased

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.118	NS	24476821
BRCA	Breast invasive carcinoma	521	3.48e-17	Significant	23000897
COAD	Colon adenocarcinoma	149	9.25e-05	Significant	22810696
GBM	Glioblastoma multiforme	157	4.45e-12	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0147	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.000265	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.82e-23	Significant	26824661
LUAD	Lung adenocarcinoma	230	6.67e-06	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.121	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.08e-08	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00188	Significant	26544944
READ	Rectum adenocarcinoma	67	0.00562	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	6.78e-05	Significant	26091043
STAD	Stomach adenocarcinoma	277	7.86e-05	Significant	25079317
THCA	Thyroid carcinoma	391	9.33e-05	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.93e-05	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.814	0.327	NS
BRCA	Breast invasive carcinoma	1079	1.371	0.172	NS
CESC	Cervical and endocervical cancers	291	2.955	0.00373	Shorter
COAD	Colon adenocarcinoma	439	1.194	0.533	NS
ESCA	Esophageal carcinoma	184	1.372	0.348	NS
GBM	Glioblastoma multiforme	158	0.722	0.201	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.063	0.761	NS
KIRC	Kidney renal clear cell carcinoma	531	1.263	0.296	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.033	0.939	NS
LAML	Acute Myeloid Leukemia	149	0.507	0.0183	Longer
LGG	Brain Lower Grade Glioma	511	0.455	0.000919	Longer
LIHC	Liver hepatocellular carcinoma	365	1.371	0.195	NS
LUAD	Lung adenocarcinoma	502	1.097	0.68	NS
LUSC	Lung squamous cell carcinoma	494	1.187	0.384	NS
OV	Ovarian serous cystadenocarcinoma	303	1.085	0.708	NS
PAAD	Pancreatic adenocarcinoma	177	1.133	0.672	NS
PCPG	Pheochromocytoma and Paraganglioma	179	768710830.231	0.112	NS
PRAD	Prostate adenocarcinoma	497	0.669	0.752	NS
READ	Rectum adenocarcinoma	159	0.417	0.126	NS
SARC	Sarcoma	259	1.841	0.0266	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.6	0.0136	Shorter
STAD	Stomach adenocarcinoma	388	0.969	0.889	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.377	NS
THCA	Thyroid carcinoma	500	0.701	0.581	NS
THYM	Thymoma	119	1600837111.407	0.0859	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	3.287	6.51e-05	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.1	0.0445	Lower
BRCA	Breast invasive carcinoma	1071	-0.01	0.751	NS
CESC	Cervical and endocervical cancers	167	-0.012	0.875	NS
COAD	Colon adenocarcinoma	445	0.059	0.213	NS
ESCA	Esophageal carcinoma	162	0.003	0.973	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.034	0.47	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.063	0.15	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.087	0.162	NS
LIHC	Liver hepatocellular carcinoma	347	0.018	0.733	NS
LUAD	Lung adenocarcinoma	507	0.032	0.467	NS
LUSC	Lung squamous cell carcinoma	497	0.044	0.322	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.016	0.78	NS
PAAD	Pancreatic adenocarcinoma	176	-0.011	0.881	NS
READ	Rectum adenocarcinoma	156	0.06	0.454	NS
SKCM	Skin Cutaneous Melanoma	410	-0.087	0.0777	NS
STAD	Stomach adenocarcinoma	392	-0.047	0.353	NS
TGCT	Testicular Germ Cell Tumors	81	-0.341	0.00183	Lower
THCA	Thyroid carcinoma	499	-0.131	0.00334	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.068	0.128	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.066	0.279	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.133	0.003	Lower
KIRC	Kidney renal clear cell carcinoma	525	-0.108	0.0134	Lower
LGG	Brain Lower Grade Glioma	514	-0.032	0.471	NS
LIHC	Liver hepatocellular carcinoma	366	0.14	0.00734	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.11	0.0595	NS
PAAD	Pancreatic adenocarcinoma	176	-0.012	0.875	NS
STAD	Stomach adenocarcinoma	406	-0.144	0.00357	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.189	1.09e-05	Higher

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for CHD7.

Summary
Symbol	CHD7
Name	chromodomain helicase DNA binding protein 7
Aliases	KIAA1416; FLJ20357; FLJ20361; CRG; CHARGE association; HH5; IS3; KAL5; ATP-dependent helicase CHD7; chromodo ......
Location	8q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
24211491	Colorectal Carcinoma with CpG methylator phenotype 1	partner	CIMP1 markers	Binding	CIMP1 markers had increased binding by CHD7, compared with all genes.