Browse CTCF in pancancer

Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain -
Function

Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome. Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays a important role in chromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory. Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point for nucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing the propagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion. Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites. Regulates asynchronous replication of IGF2/H19. Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640).

Classification
Class Modification Substrate Product PubMed
Chromatin remodelling # DNA motif # 16949368
> Gene Ontology
 
Biological Process GO:0000819 sister chromatid segregation
GO:0006304 DNA modification
GO:0006305 DNA alkylation
GO:0006306 DNA methylation
GO:0006323 DNA packaging
GO:0006333 chromatin assembly or disassembly
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006479 protein methylation
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007063 regulation of sister chromatid cohesion
GO:0008213 protein alkylation
GO:0010216 maintenance of DNA methylation
GO:0016570 histone modification
GO:0016571 histone methylation
GO:0016573 histone acetylation
GO:0016584 nucleosome positioning
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0031056 regulation of histone modification
GO:0031060 regulation of histone methylation
GO:0031497 chromatin assembly
GO:0032259 methylation
GO:0033044 regulation of chromosome organization
GO:0033045 regulation of sister chromatid segregation
GO:0034502 protein localization to chromosome
GO:0034728 nucleosome organization
GO:0035065 regulation of histone acetylation
GO:0040029 regulation of gene expression, epigenetic
GO:0040030 regulation of molecular function, epigenetic
GO:0043414 macromolecule methylation
GO:0043543 protein acylation
GO:0044728 DNA methylation or demethylation
GO:0051983 regulation of chromosome segregation
GO:0070601 centromeric sister chromatid cohesion
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071103 DNA conformation change
GO:0071459 protein localization to chromosome, centromeric region
GO:0071514 genetic imprinting
GO:0071824 protein-DNA complex subunit organization
GO:0098813 nuclear chromosome segregation
GO:1901983 regulation of protein acetylation
GO:1902275 regulation of chromatin organization
GO:2000756 regulation of peptidyl-lysine acetylation
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0031490 chromatin DNA binding
GO:0043035 chromatin insulator sequence binding
GO:0043566 structure-specific DNA binding
Cellular Component GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-1266738: Developmental Biology
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
COSMIC ID CDS change AA change Mutation Type Anatomical Site
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM1378946c.574_575insAp.D194fs*36Insertion - FrameshiftLarge_intestine
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM382811c.1134G>Tp.P378PSubstitution - coding silentLung
COSM435525c.61G>Tp.E21*Substitution - NonsenseBreast
COSM972502c.1746C>Tp.G582GSubstitution - coding silentEndometrium
COSM1378949c.872A>Gp.E291GSubstitution - MissensePancreas
COSM5949929c.1352A>Tp.D451VSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM972484c.1061C>Tp.S354FSubstitution - MissenseUrinary_tract
COSM1180830c.603_604insAp.T204fs*26Insertion - FrameshiftLarge_intestine
COSM1716411c.1437delCp.Y480fs*31Deletion - FrameshiftEndometrium
COSM4765266c.604_605insAp.T204fs*26Insertion - FrameshiftBiliary_tract
COSM972490c.1342C>Tp.R448*Substitution - NonsenseEndometrium
COSM303879c.1130G>Ap.R377HSubstitution - MissenseEndometrium
COSM3795006c.2059G>Tp.E687*Substitution - NonsenseUrinary_tract
COSM4675309c.135G>Ap.T45TSubstitution - coding silentLarge_intestine
COSM972498c.1697G>Ap.R566HSubstitution - MissenseEndometrium
COSM280199c.1034A>Gp.H345RSubstitution - MissenseLarge_intestine
COSM972472c.538C>Tp.Q180*Substitution - NonsenseEndometrium
COSM3937120c.1332A>Tp.T444TSubstitution - coding silentOesophagus
COSM1716407c.149delTp.V50fs*12Deletion - FrameshiftEndometrium
COSM303879c.1130G>Ap.R377HSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM1241050c.2155G>Ap.E719KSubstitution - MissenseOesophagus
COSM5751996c.535_536insTp.E179fs*12Insertion - FrameshiftHaematopoietic_and_lymphoid_tissue
COSM3421092c.1112G>Ap.R371HSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM972485c.1070_1071insTp.Y358fs*51Insertion - FrameshiftEndometrium
COSM1378950c.1102C>Tp.R368CSubstitution - MissenseLarge_intestine
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM2995115c.134C>Tp.T45MSubstitution - MissenseLarge_intestine
COSM435531c.781+2T>Gp.?UnknownEndometrium
COSM1302133c.1593C>Ap.T531TSubstitution - coding silentUrinary_tract
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM4776038c.1535_1560del26p.M512fs*10Deletion - FrameshiftHaematopoietic_and_lymphoid_tissue
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM303879c.1130G>Ap.R377HSubstitution - MissenseStomach
COSM4515352c.1061_1062CC>TTp.S354FSubstitution - MissenseSkin
COSM255855c.1253A>Gp.Q418RSubstitution - MissenseCentral_nervous_system
COSM1743118c.1890A>Gp.V630VSubstitution - coding silentBiliary_tract
COSM5350342c.1410T>Gp.R470RSubstitution - coding silentLung
COSM435536c.851A>Cp.H284PSubstitution - MissenseBreast
COSM2995127c.552_553insCp.Q186fs*5Insertion - FrameshiftLarge_intestine
COSM4847736c.1829C>Tp.S610FSubstitution - MissenseCervix
COSM5552848c.435G>Ap.E145ESubstitution - coding silentProstate
COSM972487c.1129C>Tp.R377CSubstitution - MissenseLarge_intestine
COSM972476c.619A>Cp.T207PSubstitution - MissenseEndometrium
COSM329033c.189G>Tp.M63ISubstitution - MissenseLiver
COSM972465c.52delAp.G19fs*43Deletion - FrameshiftEndometrium
COSM1716424c.1554C>Tp.T518TSubstitution - coding silentEndometrium
COSM5028151c.812_814delGCAp.S272delSDeletion - In frameBreast
COSM3937119c.858A>Cp.K286NSubstitution - MissenseOesophagus
COSM972490c.1342C>Tp.R448*Substitution - NonsenseEndometrium
COSM4756830c.1066T>Cp.C356RSubstitution - MissenseStomach
COSM4675310c.278C>Tp.T93ISubstitution - MissenseLarge_intestine
COSM1716416c.2081C>Tp.A694VSubstitution - MissenseEndometrium
COSM972506c.1844_1845insTp.E616fs*1Insertion - FrameshiftEndometrium
COSM3664780c.1425G>Tp.V475VSubstitution - coding silentBreast
COSM1378949c.872A>Gp.E291GSubstitution - MissensePancreas
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM1378949c.872A>Gp.E291GSubstitution - MissensePancreas
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM5752042c.1210_1211insTp.E404fs*5Insertion - FrameshiftHaematopoietic_and_lymphoid_tissue
COSM5484042c.829C>Tp.R277WSubstitution - MissenseLarge_intestine
COSM972499c.1702-1G>Cp.?UnknownEndometrium
COSM140099c.1369C>Tp.R457*Substitution - NonsenseSkin
COSM1378953c.2064delAp.E691fs*30Deletion - FrameshiftLarge_intestine
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM435534c.850C>Tp.H284YSubstitution - MissenseBreast
COSM5817870c.1230T>Cp.Y410YSubstitution - coding silentLiver
COSM5752710c.852C>Gp.H284QSubstitution - MissenseBreast
COSM356454c.239G>Tp.G80VSubstitution - MissenseLung
COSM435528c.363T>Ap.P121PSubstitution - coding silentBreast
COSM435533c.847C>Tp.R283CSubstitution - MissenseBreast
COSM435534c.850C>Tp.H284YSubstitution - MissenseBreast
COSM972482c.941_942delACp.T317fs*91Deletion - FrameshiftEndometrium
COSM972470c.488G>Ap.G163ESubstitution - MissenseEndometrium
COSM1378953c.2064delAp.E691fs*30Deletion - FrameshiftLarge_intestine
COSM3421092c.1112G>Ap.R371HSubstitution - MissenseLarge_intestine
COSM972486c.1094A>Cp.K365TSubstitution - MissenseEndometrium
COSM972487c.1129C>Tp.R377CSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3957718c.1455T>Cp.H485HSubstitution - coding silentLung
COSM972490c.1342C>Tp.R448*Substitution - NonsenseHaematopoietic_and_lymphoid_tissue
COSM144805c.877C>Ap.P293TSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM2995144c.1042G>Ap.E348KSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM140099c.1369C>Tp.R457*Substitution - NonsenseHaematopoietic_and_lymphoid_tissue
COSM972488c.1133C>Tp.P378LSubstitution - MissenseEndometrium
COSM1716406c.1407C>Ap.C469*Substitution - NonsenseEndometrium
COSM972490c.1342C>Tp.R448*Substitution - NonsenseEndometrium
COSM972472c.538C>Tp.Q180*Substitution - NonsenseEndometrium
COSM1180830c.603_604insAp.T204fs*26Insertion - FrameshiftStomach
COSM2995153c.1408C>Tp.R470CSubstitution - MissenseLarge_intestine
COSM4061901c.838A>Cp.N280HSubstitution - MissenseStomach
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM1716422c.948_949delCAp.T317fs*91Deletion - FrameshiftEndometrium
COSM3511046c.999C>Tp.T333TSubstitution - coding silentSkin
COSM2995127c.552_553insCp.Q186fs*5Insertion - FrameshiftLarge_intestine
COSM972469c.433G>Tp.E145*Substitution - NonsenseEndometrium
COSM194440c.1807C>Tp.R603CSubstitution - MissenseLarge_intestine
COSM5752724c.1999+1G>Tp.?UnknownBreast
COSM972492c.1464A>Gp.S488SSubstitution - coding silentEndometrium
COSM3511047c.1053C>Tp.F351FSubstitution - coding silentSkin
COSM972471c.535G>Tp.E179*Substitution - NonsenseEndometrium
COSM4818694c.836C>Tp.S279LSubstitution - MissenseCervix
COSM166018c.612_613delAAp.K205fs*24Deletion - FrameshiftBreast
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftLiver
COSM2995153c.1408C>Tp.R470CSubstitution - MissenseLarge_intestine
COSM4675312c.1999+1G>Ap.?UnknownLarge_intestine
COSM211878c.148G>Cp.V50LSubstitution - MissenseBreast
COSM4533140c.1950G>Ap.K650KSubstitution - coding silentSkin
COSM972490c.1342C>Tp.R448*Substitution - NonsenseEndometrium
COSM972484c.1061C>Tp.S354FSubstitution - MissenseBreast
COSM4765266c.604_605insAp.T204fs*26Insertion - FrameshiftStomach
COSM1749705c.1231A>Gp.I411VSubstitution - MissenseUrinary_tract
COSM4969421c.1952G>Ap.R651QSubstitution - MissenseCentral_nervous_system
COSM1716409c.1118A>Tp.H373LSubstitution - MissenseEndometrium
COSM265892c.1507G>Tp.A503SSubstitution - MissenseLarge_intestine
COSM1716410c.1248T>Gp.F416LSubstitution - MissenseEndometrium
COSM307649c.1518+1G>Tp.?UnknownKidney
COSM3969648c.1811C>Gp.S604CSubstitution - MissenseCentral_nervous_system
COSM5028152c.874A>Gp.R292GSubstitution - MissenseBreast
COSM1202568c.1213A>Gp.K405ESubstitution - MissenseLarge_intestine
COSM255855c.1253A>Gp.Q418RSubstitution - MissenseCentral_nervous_system
COSM255233c.1837+4A>Gp.?UnknownCentral_nervous_system
COSM1716417c.2164C>Ap.L722ISubstitution - MissenseEndometrium
COSM303879c.1130G>Ap.R377HSubstitution - MissenseEndometrium
COSM972499c.1702-1G>Cp.?UnknownEndometrium
COSM5565405c.82C>Tp.R28CSubstitution - MissenseProstate
COSM972479c.895_896delTGp.C299fs*15Deletion - FrameshiftEndometrium
COSM972500c.1704T>Ap.N568KSubstitution - MissenseEndometrium
COSM972496c.1569C>Ap.Y523*Substitution - NonsenseEndometrium
COSM1716415c.610delAp.T204fs*18Deletion - FrameshiftEndometrium
COSM5041869c.1505A>Tp.Y502FSubstitution - MissenseLiver
COSM471948c.1548C>Tp.T516TSubstitution - coding silentKidney
COSM972475c.592C>Tp.Q198*Substitution - NonsenseEndometrium
COSM1249366c.19G>Ap.E7KSubstitution - MissenseStomach
COSM972505c.1837+1G>Cp.?UnknownEndometrium
COSM471947c.1444C>Ap.L482ISubstitution - MissenseKidney
COSM1180830c.603_604insAp.T204fs*26Insertion - FrameshiftLarge_intestine
COSM1716415c.610delAp.T204fs*18Deletion - FrameshiftEndometrium
COSM1716419c.1056G>Tp.K352NSubstitution - MissenseEndometrium
COSM1378951c.1390G>Ap.E464KSubstitution - MissenseLarge_intestine
COSM3511048c.1650C>Tp.F550FSubstitution - coding silentSkin
COSM5751613c.702_703insTp.G235fs*7Insertion - FrameshiftHaematopoietic_and_lymphoid_tissue
COSM972488c.1133C>Tp.P378LSubstitution - MissenseEndometrium
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM74288c.873G>Cp.E291DSubstitution - MissenseOvary
COSM972481c.940_941insACp.G318fs*16Insertion - FrameshiftEndometrium
COSM972473c.556C>Tp.Q186*Substitution - NonsenseEndometrium
COSM435534c.850C>Tp.H284YSubstitution - MissenseBreast
COSM972484c.1061C>Tp.S354FSubstitution - MissenseSkin
COSM5596546c.1312C>Tp.H438YSubstitution - MissenseSkin
COSM972507c.1891G>Tp.E631*Substitution - NonsenseCervix
COSM220312c.773A>Gp.K258RSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM1493700c.86G>Ap.R29QSubstitution - MissenseKidney
COSM1679187c.1097T>Gp.L366*Substitution - NonsenseLarge_intestine
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM5773452c.1157A>Gp.Y386CSubstitution - MissenseBreast
COSM972486c.1094A>Cp.K365TSubstitution - MissenseEndometrium
COSM1742484c.1126G>Ap.E376KSubstitution - MissenseUrinary_tract
COSM435532c.782-1_782insTACp.G261>VRComplex - insertion inframeBreast
COSM972464c.5A>Gp.E2GSubstitution - MissenseEndometrium
COSM4765267c.2064_2065insAp.E691fs*5Insertion - FrameshiftStomach
COSM194431c.1024C>Tp.R342CSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM435538c.1294G>Tp.E432*Substitution - NonsenseBreast
COSM2995145c.1074C>Tp.Y358YSubstitution - coding silentUpper_aerodigestive_tract
COSM703850c.1654C>Tp.P552SSubstitution - MissenseLung
COSM1478995c.1A>Gp.M1VSubstitution - MissenseBreast
COSM303879c.1130G>Ap.R377HSubstitution - MissenseEndometrium
COSM4675311c.556_557delCAp.Q186fs*4Deletion - FrameshiftLarge_intestine
COSM5024986c.803G>Ap.C268YSubstitution - MissenseBreast
COSM5752705c.349C>Tp.Q117*Substitution - NonsenseBreast
COSM5903094c.508G>Ap.G170RSubstitution - MissenseSkin
COSM972490c.1342C>Tp.R448*Substitution - NonsenseEndometrium
COSM4061904c.1181T>Cp.L394PSubstitution - MissenseStomach
COSM5751202c.678C>ACp.Y226fs*1Complex - frameshiftHaematopoietic_and_lymphoid_tissue
COSM4477585c.2166C>Tp.L722LSubstitution - coding silentSkin
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM417325c.1602G>Ap.Q534QSubstitution - coding silentUrinary_tract
COSM1716423c.1025G>Ap.R342HSubstitution - MissenseEndometrium
COSM290448c.71C>Gp.T24SSubstitution - MissenseLarge_intestine
COSM972483c.1027T>Cp.Y343HSubstitution - MissenseEndometrium
COSM4464593c.1341C>Tp.A447ASubstitution - coding silentSkin
COSM4061906c.1546A>Gp.T516ASubstitution - MissenseStomach
COSM5713848c.1798A>Tp.R600*Substitution - NonsenseHaematopoietic_and_lymphoid_tissue
COSM5916509c.38C>Tp.S13FSubstitution - MissenseSkin
COSM1180830c.603_604insAp.T204fs*26Insertion - FrameshiftStomach
COSM972472c.538C>Tp.Q180*Substitution - NonsenseEndometrium
COSM435535c.850C>Ap.H284NSubstitution - MissenseBreast
COSM5429908c.78G>Ap.Q26QSubstitution - coding silentOesophagus
COSM2995163c.1886C>Tp.A629VSubstitution - MissenseLarge_intestine
COSM5752724c.1999+1G>Tp.?UnknownBreast
COSM1378952c.1555G>Ap.G519RSubstitution - MissenseLarge_intestine
COSM3511049c.1964C>Tp.P655LSubstitution - MissenseSkin
COSM972490c.1342C>Tp.R448*Substitution - NonsenseEndometrium
COSM972467c.334G>Tp.E112*Substitution - NonsenseEndometrium
COSM140099c.1369C>Tp.R457*Substitution - NonsenseHaematopoietic_and_lymphoid_tissue
COSM5055002c.1570G>Ap.A524TSubstitution - MissenseStomach
COSM140099c.1369C>Tp.R457*Substitution - NonsenseHaematopoietic_and_lymphoid_tissue
COSM1158713c.3G>Tp.M1ISubstitution - MissensePancreas
COSM972508c.1895delTp.I632fs*10Deletion - FrameshiftEndometrium
COSM972466c.214C>Tp.Q72*Substitution - NonsenseEndometrium
COSM435527c.102A>Gp.E34ESubstitution - coding silentBreast
COSM1716415c.610delAp.T204fs*18Deletion - FrameshiftEndometrium
COSM1478998c.683T>Cp.F228SSubstitution - MissenseBreast
COSM4919922c.161T>Cp.V54ASubstitution - MissenseLiver
COSM435539c.1873G>Tp.E625*Substitution - NonsenseBreast
COSM972501c.1738C>Ap.P580TSubstitution - MissenseEndometrium
COSM2995162c.1818A>Gp.K606KSubstitution - coding silentBone
COSM972509c.1913C>Tp.P638LSubstitution - MissenseEndometrium
COSM2995129c.604delAp.T204fs*18Deletion - FrameshiftStomach
COSM4473076c.1826C>Tp.S609FSubstitution - MissenseSkin
COSM4765266c.604_605insAp.T204fs*26Insertion - FrameshiftBiliary_tract
COSM972487c.1129C>Tp.R377CSubstitution - MissenseEndometrium
COSM1745506c.1703_1704insTp.T569fs*7Insertion - FrameshiftUrinary_tract
COSM122403c.1396G>Ap.G466SSubstitution - MissenseUpper_aerodigestive_tract
COSM1180830c.603_604insAp.T204fs*26Insertion - FrameshiftStomach
COSM703850c.1654C>Tp.P552SSubstitution - MissenseSkin
COSM4528684c.1556G>Ap.G519ESubstitution - MissenseLiver
COSM4169929c.1927C>Tp.P643SSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM5458575c.1698T>Cp.R566RSubstitution - coding silentLarge_intestine
COSM1679187c.1097T>Gp.L366*Substitution - NonsenseLarge_intestine
COSM1749705c.1231A>Gp.I411VSubstitution - MissenseUrinary_tract
COSM972468c.367A>Gp.T123ASubstitution - MissenseEndometrium
COSM252457c.1103G>Ap.R368HSubstitution - MissenseOvary
COSM1716415c.610delAp.T204fs*18Deletion - FrameshiftEndometrium
COSM972490c.1342C>Tp.R448*Substitution - NonsenseEndometrium
COSM3370507c.1741G>Cp.D581HSubstitution - MissenseThyroid
COSM972491c.1454A>Gp.H485RSubstitution - MissenseEndometrium
COSM972495c.1549C>Tp.H517YSubstitution - MissenseEndometrium
COSM703849c.1689A>Gp.T563TSubstitution - coding silentLung
COSM4141845c.629G>Ap.S210NSubstitution - MissenseOvary
COSM1716415c.610delAp.T204fs*18Deletion - FrameshiftEndometrium
COSM972490c.1342C>Tp.R448*Substitution - NonsenseEndometrium
COSM5596545c.1850C>Tp.P617LSubstitution - MissenseSkin
COSM1166761c.86delGp.E30fs*32Deletion - FrameshiftHaematopoietic_and_lymphoid_tissue
COSM1478997c.677A>Gp.Y226CSubstitution - MissenseBreast
COSM1180830c.603_604insAp.T204fs*26Insertion - FrameshiftLarge_intestine
COSM5656253c.1651G>Tp.V551FSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM5785673c.1160C>Tp.A387VSubstitution - MissenseBreast
COSM1716415c.610delAp.T204fs*18Deletion - FrameshiftEndometrium
COSM5557462c.2161A>Tp.I721FSubstitution - MissenseProstate
COSM1716413c.405delGp.A137fs*17Deletion - FrameshiftEndometrium
COSM1180830c.603_604insAp.T204fs*26Insertion - FrameshiftLarge_intestine
COSM3370508c.1779G>Cp.K593NSubstitution - MissenseThyroid
COSM4169930c.1041C>Ap.H347QSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM972480c.935A>Gp.H312RSubstitution - MissenseEndometrium
COSM5687513c.332G>Cp.G111ASubstitution - MissenseSoft_tissue
COSM1609522c.2145C>Gp.D715ESubstitution - MissenseLiver
COSM1716408c.853_854AT>Gp.M285fs*25Complex - frameshiftEndometrium
COSM4061903c.1016G>Ap.R339QSubstitution - MissenseStomach
COSM3795005c.1051T>Cp.F351LSubstitution - MissenseUrinary_tract
COSM972490c.1342C>Tp.R448*Substitution - NonsenseEndometrium
COSM194440c.1807C>Tp.R603CSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM972467c.334G>Tp.E112*Substitution - NonsenseEndometrium
COSM4477225c.2135C>Tp.P712LSubstitution - MissenseSkin
COSM194437c.1480C>Tp.R494CSubstitution - MissensePancreas
COSM972481c.940_941insACp.G318fs*16Insertion - FrameshiftEndometrium
COSM5055001c.1069G>Ap.D357NSubstitution - MissenseStomach
COSM5751489c.414T>ATp.Y138fs*1Complex - frameshiftHaematopoietic_and_lymphoid_tissue
COSM1302132c.1163G>Ap.S388NSubstitution - MissenseUrinary_tract
COSM1180830c.603_604insAp.T204fs*26Insertion - FrameshiftLarge_intestine
COSM4776038c.1535_1560del26p.M512fs*10Deletion - FrameshiftHaematopoietic_and_lymphoid_tissue
COSM5762864c.332G>Ap.G111ESubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM3664780c.1425G>Tp.V475VSubstitution - coding silentBreast
COSM1644522c.1979A>Gp.N660SSubstitution - MissenseSalivary_gland
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM3511045c.84C>Tp.R28RSubstitution - coding silentSkin
COSM4916907c.1620G>Ap.M540ISubstitution - MissenseLiver
COSM5752710c.852C>Gp.H284QSubstitution - MissenseBreast
COSM972488c.1133C>Tp.P378LSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM5789665c.1053C>Gp.F351LSubstitution - MissenseBreast
COSM4675313c.2055A>Gp.I685MSubstitution - MissenseLarge_intestine
COSM972494c.1544G>Ap.R515HSubstitution - MissenseEndometrium
COSM1249366c.19G>Ap.E7KSubstitution - MissenseLarge_intestine
COSM1716420c.713C>Ap.S238*Substitution - NonsenseEndometrium
COSM4912011c.982G>Tp.D328YSubstitution - MissenseLiver
COSM1609522c.2145C>Gp.D715ESubstitution - MissenseLiver
COSM435526c.61_64delGAGAp.K23fs*38Deletion - FrameshiftBreast
COSM4528684c.1556G>Ap.G519ESubstitution - MissenseSkin
COSM972484c.1061C>Tp.S354FSubstitution - MissenseUrinary_tract
COSM5498604c.713C>Tp.S238LSubstitution - MissenseBiliary_tract
COSM1479000c.1689A>Tp.T563TSubstitution - coding silentBreast
COSM972474c.591T>Ap.Y197*Substitution - NonsenseEndometrium
COSM1158713c.3G>Tp.M1ISubstitution - MissensePancreas
COSM435529c.573G>Ap.W191*Substitution - NonsenseBreast
COSM435537c.1132C>Gp.P378ASubstitution - MissenseBreast
COSM4061902c.981C>Tp.C327CSubstitution - coding silentStomach
COSM4617689c.638G>Ap.R213HSubstitution - MissenseLarge_intestine
COSM5814711c.967A>Tp.K323*Substitution - NonsenseLiver
COSM1716412c.422_426AAGTG>Tp.E141fs*12Complex - frameshiftEndometrium
COSM972484c.1061C>Tp.S354FSubstitution - MissenseEndometrium
COSM4061903c.1016G>Ap.R339QSubstitution - MissenseStomach
COSM4061908c.1951C>Tp.R651WSubstitution - MissenseStomach
COSM303879c.1130G>Ap.R377HSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM140099c.1369C>Tp.R457*Substitution - NonsenseEndometrium
COSM1158713c.3G>Tp.M1ISubstitution - MissensePancreas
COSM1478999c.862C>Gp.H288DSubstitution - MissenseBreast
COSM303879c.1130G>Ap.R377HSubstitution - MissenseBreast
COSM4061909c.1983G>Ap.Q661QSubstitution - coding silentStomach
COSM972504c.1810delTp.S604fs*27Deletion - FrameshiftEndometrium
COSM140099c.1369C>Tp.R457*Substitution - NonsenseLarge_intestine
COSM1716415c.610delAp.T204fs*18Deletion - FrameshiftEndometrium
COSM1202569c.2077G>Ap.D693NSubstitution - MissenseLarge_intestine
COSM972486c.1094A>Cp.K365TSubstitution - MissenseEndometrium
COSM972497c.1584C>Ap.C528*Substitution - NonsenseEndometrium
COSM972507c.1891G>Tp.E631*Substitution - NonsenseEndometrium
COSM703848c.2166C>Gp.L722LSubstitution - coding silentLung
COSM972484c.1061C>Tp.S354FSubstitution - MissenseBreast
COSM5954856c.934C>Tp.H312YSubstitution - MissenseUpper_aerodigestive_tract
COSM5882746c.912A>Tp.R304SSubstitution - MissenseBreast
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM5571619c.1651G>Ap.V551ISubstitution - MissenseProstate
COSM435531c.781+2T>Gp.?UnknownBreast
COSM255855c.1253A>Gp.Q418RSubstitution - MissenseLiver
COSM1158713c.3G>Tp.M1ISubstitution - MissensePancreas
COSM4888093c.2180G>Tp.R727LSubstitution - MissenseUpper_aerodigestive_tract
COSM972486c.1094A>Cp.K365TSubstitution - MissenseEndometrium
COSM1716415c.610delAp.T204fs*18Deletion - FrameshiftEndometrium
COSM3957719c.1598G>Tp.R533LSubstitution - MissenseLung
COSM4526985c.1432G>Ap.E478KSubstitution - MissenseSkin
COSM972489c.1168_1169insGTp.D390fs*6Insertion - FrameshiftEndometrium
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM471948c.1548C>Tp.T516TSubstitution - coding silentUpper_aerodigestive_tract
COSM4579171c.1089C>Tp.V363VSubstitution - coding silentBone
COSM972478c.781+1G>Ap.?UnknownEndometrium
COSM972503c.1768G>Tp.E590*Substitution - NonsenseEndometrium
COSM1716418c.626_627delAGp.S210fs*19Deletion - FrameshiftEndometrium
COSM4129213c.41A>Gp.E14GSubstitution - MissenseThyroid
COSM5427737c.1757A>Gp.E586GSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM4844132c.1514G>Cp.R505TSubstitution - MissenseCervix
COSM972466c.214C>Tp.Q72*Substitution - NonsenseKidney
COSM4061905c.1518+1G>Ap.?UnknownStomach
COSM3701108c.649G>Tp.E217*Substitution - NonsenseLiver
COSM5038753c.863delAp.H288fs*22Deletion - FrameshiftLiver
COSM1717115c.1660G>Tp.A554SSubstitution - MissenseOvary
COSM1716421c.1702-3T>Gp.?UnknownEndometrium
COSM4129212c.40G>Ap.E14KSubstitution - MissenseThyroid
COSM3733792c.1543C>Tp.R515CSubstitution - MissensePancreas
COSM1716414c.610_611insAp.T204fs*26Insertion - FrameshiftEndometrium
COSM2995157c.1566delTp.Y523fs*61Deletion - FrameshiftLarge_intestine
COSM4129214c.43A>Tp.T15SSubstitution - MissenseThyroid
COSM5752041c.1837+1_1837+2insTp.?UnknownHaematopoietic_and_lymphoid_tissue
COSM1478997c.677A>Gp.Y226CSubstitution - MissenseBreast
COSM220525c.1364A>Gp.H455RSubstitution - MissenseHaematopoietic_and_lymphoid_tissue
COSM435530c.772A>Gp.K258ESubstitution - MissenseBreast
COSM1717102c.136G>Ap.D46NSubstitution - MissenseOvary
COSM4579172c.1861G>Ap.D621NSubstitution - MissenseBone
COSM1378945c.540_541insGp.E182fs*9Insertion - FrameshiftLarge_intestine
COSM972493c.1516C>Tp.Q506*Substitution - NonsenseEndometrium
COSM972477c.767_771delAAATTp.I257fs*11Deletion - FrameshiftEndometrium
COSM972487c.1129C>Tp.R377CSubstitution - MissenseEndometrium
COSM4061907c.1655C>Ap.P552HSubstitution - MissenseStomach
> Text Mining based Variations
 
PMID Variation Cancer Evidence
26747525mutationHead and Neck Squamous Cell CarcinomaA number of genes were uniquely mutated in the progressor cohort including increased frequency of truncating mutations in CTCF (P=0.007).
26330387mutationEndometrial CarcinomaThe chromosome 16q22 tumor suppressor genes CTCF and ZFHX3 are both frequently mutated in EEC, but their respective roles in outcome have not been determined.
25469243mutationOvarian CarcinomaRecently, large-scale sequencing has identified frequent ribonuclease type III (DICER1), CCCTC-binding factor (CTCF), ribosomal protein L22 (RPL22), DNA (cytosine-5-)-methyltransferase 3α (DNMT3A), transformation/transcription domain-associated protein (TRRAP), isocitrate dehydrogenase (IDH)1 and IDH2 hotspot mutations in diverse types of cancer.
24658009mutationEndometrial CarcinomaCTCF mutations were identified in 13%, with CTCF hotspot frameshift mutations at p.T204, all observed solely in the endometrioid subtype, but with no association with outcome.
24130125mutationEndometrial CarcinomaAlthough CTCF was described as a significantly mutated gene by the endometrial cancer TCGA, the A track variants leading to T204 frameshifts were not reported.
23007606mutationTriple-Negative Breast Cancer FindingInterestingly, covariation of CDH1, CDH3, CTCF and E2F4 was found to be associated with triple negative breast cancer and HER-2 receptor status.
21390130mutationAcute Lymphoblastic LeukemiaThis identified 52 somatic non-synonymous mutations in 32 genes, many of which were novel, including the transcriptional coactivators CREBBP and NCOR1, the transcription factors ERG, SPI1, TCF4 and TCF7L2, components of the Ras signalling pathway, histone genes, genes involved in histone modification (CREBBP and CTCF), and genes previously shown to be targets of recurring DNA copy number alteration in ALL.
28319062MutationEndometrial CarcinomaCTCF is frequently mutated in endometrial cancer.
27974201MutationMelanomaCTCF binding sites are frequently mutated in cancer, but how these mutations accumulate and whether they broadly perturb CTCF binding are not well understood. While topologically associating domains with mutated CTCF anchors in melanoma contain differentially expressed cancer-associated genes, CTCF motif mutations appear generally under neutral selection.
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
Uniprot ID Position Amino Acid Description Upstream Enzyme Affected By Mutation Amino Acid Sequence Variant
P49711289TPhosphothreonine-NoNone detected
P49711317TPhosphothreonine-NoNone detected
P49711374TPhosphothreonine-NoNone detected
P49711402SPhosphoserine-NoNone detected
P49711609SPhosphoserine-NoNone detected
P49711610SPhosphoserine-Yesp.S610F (cancer: CESC)
P49711612SPhosphoserine-NoNone detected
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
BLCABladder urothelial carcinoma194086.1056.0650.0310.796NS
BRCABreast invasive carcinoma11211006.2496.2760.0470.237NS
CESCCervical and endocervical cancers33066.0886.212NANANA
COADColon adenocarcinoma414596.2646.218-0.0260.641NS
ESCAEsophageal carcinoma111855.8836.220.3180.0103NS
GBMGlioblastoma multiforme51665.8296.027NANANA
HNSCHead and Neck squamous cell carcinoma445225.8895.940.0460.494NS
KIRCKidney renal clear cell carcinoma725346.276.097-0.2231.81e-09NS
KIRPKidney renal papillary cell carcinoma322916.0865.929-0.1420.0348NS
LAMLAcute Myeloid Leukemia0173NA6.821NANANA
LGGBrain Lower Grade Glioma0530NA6.331NANANA
LIHCLiver hepatocellular carcinoma503735.044.993-0.0530.381NS
LUADLung adenocarcinoma595175.9235.940.0410.45NS
LUSCLung squamous cell carcinoma515015.9066.0950.2331.72e-05NS
OVOvarian serous cystadenocarcinoma0307NA6.067NANANA
PAADPancreatic adenocarcinoma41796.0275.938NANANA
PCPGPheochromocytoma and Paraganglioma31845.6865.664NANANA
PRADProstate adenocarcinoma524986.1186.064-0.0620.196NS
READRectum adenocarcinoma101676.2826.2460.0440.799NS
SARCSarcoma22635.745.808NANANA
SKCMSkin Cutaneous Melanoma14726.1296.107NANANA
STADStomach adenocarcinoma354156.0786.2910.2581.29e-05NS
TGCTTesticular Germ Cell Tumors0156NA6.49NANANA
THCAThyroid carcinoma595096.0815.961-0.1060.00624NS
THYMThymoma21207.216.833NANANA
UCECUterine Corpus Endometrial Carcinoma355466.2155.896-0.3083.01e-05NS
> Cancer Cell Line Encyclopedia (CCLE)
 



Tissue Cell Line Expression Level (Microarray)
Autonomic ganglia CHP126 10.7
Autonomic ganglia CHP212 10.5
Autonomic ganglia IMR32 10.6
Autonomic ganglia KELLY 10.4
Autonomic ganglia KPNRTBM1 10.3
Autonomic ganglia KPNSI9S 9.6
Autonomic ganglia KPNYN 10.7
Autonomic ganglia MHHNB11 10.1
Autonomic ganglia NB1 10.1
Autonomic ganglia NH6 10.3
Autonomic ganglia SHSY5Y 9.7
Autonomic ganglia SIMA 10.3
Autonomic ganglia SKNAS 10
Autonomic ganglia SKNBE2 10.6
Autonomic ganglia SKNDZ 10.6
Autonomic ganglia SKNFI 9.7
Autonomic ganglia SKNSH 9.6
Biliary tract HUCCT1 9.6
Biliary tract HUH28 9.3
Biliary tract SNU1079 10
Biliary tract SNU1196 10.5
Biliary tract SNU245 10.4
Biliary tract SNU308 10.3
Biliary tract SNU478 9.8
Bone 143B 10.4
Bone A673 10.1
Bone CADOES1 10
Bone CAL78 9.5
Bone G292CLONEA141B1 9.9
Bone HOS 9.9
Bone HS706T 9.4
Bone HS737T 9.1
Bone HS819T 8.9
Bone HS821T 9.2
Bone HS822T 8.7
Bone HS863T 9
Bone HS870T 9.1
Bone HS888T 9.3
Bone MG63 9.6
Bone MHHES1 10.3
Bone OUMS27 9.5
Bone RDES 10.3
Bone SJSA1 9.6
Bone SKES1 10.4
Bone SKNMC 10
Bone SW1353 9.5
Bone T173 9.1
Bone TC71 10.1
Bone U2OS 10.4
Breast AU565 9.6
Breast BT20 10.7
Breast BT474 10.3
Breast BT483 10.4
Breast BT549 9.8
Breast CAL120 9.2
Breast CAL148 10.3
Breast CAL51 10.5
Breast CAL851 9.5
Breast CAMA1 10.5
Breast DU4475 10
Breast EFM192A 10.1
Breast EFM19 9.8
Breast EVSAT 9.9
Breast HCC1143 9.5
Breast HCC1187 9.7
Breast HCC1395 9.9
Breast HCC1419 9.8
Breast HCC1428 10.5
Breast HCC1500 10
Breast HCC1569 9.6
Breast HCC1599 9.8
Breast HCC1806 9.7
Breast HCC1937 9.9
Breast HCC1954 10.2
Breast HCC202 10.2
Breast HCC2157 9.3
Breast HCC2218 9.3
Breast HCC38 9.9
Breast HCC70 10.4
Breast HDQP1 9.5
Breast HMC18 9.8
Breast HS274T 9.1
Breast HS281T 9
Breast HS343T 9.1
Breast HS578T 8.6
Breast HS606T 9
Breast HS739T 8.7
Breast HS742T 8.3
Breast JIMT1 9.2
Breast KPL1 10.7
Breast MCF7 10.2
Breast MDAMB134VI 9.4
Breast MDAMB157 9.2
Breast MDAMB175VII 10.1
Breast MDAMB231 9.2
Breast MDAMB361 10.6
Breast MDAMB415 9.6
Breast MDAMB436 9.3
Breast MDAMB453 10.7
Breast MDAMB468 9.4
Breast SKBR3 9.7
Breast T47D 10
Breast UACC812 9.6
Breast UACC893 10.5
Breast YMB1 10.4
Breast ZR751 10
Breast ZR7530 9.5
Central nervous system 1321N1 10
Central nervous system 42MGBA 9.7
Central nervous system 8MGBA 9.5
Central nervous system A172 9.1
Central nervous system AM38 9.9
Central nervous system BECKER 9.9
Central nervous system CAS1 9.6
Central nervous system CCFSTTG1 10.1
Central nervous system D283MED 9.8
Central nervous system D341MED 9.6
Central nervous system DAOY 9.8
Central nervous system DBTRG05MG 9.1
Central nervous system DKMG 9.4
Central nervous system GAMG 9.4
Central nervous system GB1 9.7
Central nervous system GI1 9.6
Central nervous system GMS10 9.8
Central nervous system GOS3 9.6
Central nervous system H4 9.6
Central nervous system HS683 10
Central nervous system KALS1 9.7
Central nervous system KG1C 8.9
Central nervous system KNS42 9.4
Central nervous system KNS60 9.5
Central nervous system KNS81 9.2
Central nervous system KS1 9.6
Central nervous system LN18 10.1
Central nervous system LN229 10
Central nervous system M059K 9
Central nervous system MOGGCCM 9.3
Central nervous system MOGGUVW 9.4
Central nervous system NMCG1 9.8
Central nervous system ONS76 9.8
Central nervous system SF126 9.3
Central nervous system SF295 9.8
Central nervous system SNB19 10.2
Central nervous system SNU1105 9.5
Central nervous system SNU201 9.8
Central nervous system SNU466 9.3
Central nervous system SNU489 9.6
Central nervous system SNU626 9.4
Central nervous system SNU738 9.8
Central nervous system SW1088 9.8
Central nervous system SW1783 9.2
Central nervous system T98G 9.6
Central nervous system TM31 9.6
Central nervous system U118MG 9.4
Central nervous system U138MG 9.6
Central nervous system U251MG 10
Central nervous system U87MG 9.3
Central nervous system YH13 9.6
Central nervous system YKG1 10
Endometrium AN3CA 9.6
Endometrium COLO684 10
Endometrium EFE184 9
Endometrium EN 9.6
Endometrium ESS1 9.7
Endometrium HEC108 10
Endometrium HEC151 9.8
Endometrium HEC1A 10
Endometrium HEC1B 11.1
Endometrium HEC251 9.5
Endometrium HEC265 10.1
Endometrium HEC50B 9.9
Endometrium HEC59 9.9
Endometrium HEC6 9.9
Endometrium ISHIKAWAHERAKLIO02ER 10.1
Endometrium JHUEM1 9.5
Endometrium JHUEM2 9.7
Endometrium JHUEM3 9.6
Endometrium KLE 9.3
Endometrium MFE280 9.8
Endometrium MFE296 10.7
Endometrium MFE319 9
Endometrium RL952 10
Endometrium SNGM 9.8
Endometrium SNU1077 8.9
Endometrium SNU685 9.1
Endometrium TEN 10.1
Haematopoietic and lymphoid 697 11.1
Haematopoietic and lymphoid A3KAW 10.4
Haematopoietic and lymphoid A4FUK 10.5
Haematopoietic and lymphoid ALLSIL 11.3
Haematopoietic and lymphoid AML193 10.2
Haematopoietic and lymphoid AMO1 10.6
Haematopoietic and lymphoid BCP1 10.3
Haematopoietic and lymphoid BDCM 10
Haematopoietic and lymphoid BL41 11.3
Haematopoietic and lymphoid BL70 11.2
Haematopoietic and lymphoid BV173 10.5
Haematopoietic and lymphoid CA46 11.4
Haematopoietic and lymphoid CI1 10.7
Haematopoietic and lymphoid CMK115 10.5
Haematopoietic and lymphoid CMK86 10.4
Haematopoietic and lymphoid CMK 10.3
Haematopoietic and lymphoid CMLT1 11.1
Haematopoietic and lymphoid COLO775 10.3
Haematopoietic and lymphoid DAUDI 10.9
Haematopoietic and lymphoid DB 10.3
Haematopoietic and lymphoid DEL 10.1
Haematopoietic and lymphoid DND41 10.9
Haematopoietic and lymphoid DOHH2 11
Haematopoietic and lymphoid EB1 10.7
Haematopoietic and lymphoid EB2 10.6
Haematopoietic and lymphoid EHEB 9.9
Haematopoietic and lymphoid EJM 10
Haematopoietic and lymphoid EM2 10
Haematopoietic and lymphoid EOL1 10.5
Haematopoietic and lymphoid F36P 9.8
Haematopoietic and lymphoid GA10 11.3
Haematopoietic and lymphoid GDM1 9.8
Haematopoietic and lymphoid GRANTA519 10.5
Haematopoietic and lymphoid HDLM2 9.5
Haematopoietic and lymphoid HDMYZ 9.1
Haematopoietic and lymphoid HEL9217 10.1
Haematopoietic and lymphoid HEL 10.1
Haematopoietic and lymphoid HH 10.3
Haematopoietic and lymphoid HL60 10.3
Haematopoietic and lymphoid HPBALL 10.7
Haematopoietic and lymphoid HS604T 9.2
Haematopoietic and lymphoid HS611T 10.4
Haematopoietic and lymphoid HS616T 8.9
Haematopoietic and lymphoid HS751T 9.5
Haematopoietic and lymphoid HT 10.6
Haematopoietic and lymphoid HTK 10
Haematopoietic and lymphoid HUNS1 10.4
Haematopoietic and lymphoid HUT102 9.9
Haematopoietic and lymphoid HUT78 10.4
Haematopoietic and lymphoid JEKO1 11.1
Haematopoietic and lymphoid JK1 10.3
Haematopoietic and lymphoid JM1 11
Haematopoietic and lymphoid JURKAT 11.2
Haematopoietic and lymphoid JURLMK1 10.1
Haematopoietic and lymphoid JVM2 9.3
Haematopoietic and lymphoid JVM3 10.3
Haematopoietic and lymphoid K562 9
Haematopoietic and lymphoid KARPAS299 10.4
Haematopoietic and lymphoid KARPAS422 10
Haematopoietic and lymphoid KARPAS620 11.1
Haematopoietic and lymphoid KASUMI1 10.6
Haematopoietic and lymphoid KASUMI2 11.3
Haematopoietic and lymphoid KASUMI6 10.5
Haematopoietic and lymphoid KCL22 9.8
Haematopoietic and lymphoid KE37 11.4
Haematopoietic and lymphoid KE97 10
Haematopoietic and lymphoid KG1 10.7
Haematopoietic and lymphoid KHM1B 10
Haematopoietic and lymphoid KIJK 9.8
Haematopoietic and lymphoid KMH2 10.6
Haematopoietic and lymphoid KMM1 11
Haematopoietic and lymphoid KMS11 10.4
Haematopoietic and lymphoid KMS12BM 10.3
Haematopoietic and lymphoid KMS18 10.4
Haematopoietic and lymphoid KMS20 9.8
Haematopoietic and lymphoid KMS21BM 10.1
Haematopoietic and lymphoid KMS26 10.2
Haematopoietic and lymphoid KMS27 10.1
Haematopoietic and lymphoid KMS28BM 10.3
Haematopoietic and lymphoid KMS34 10.2
Haematopoietic and lymphoid KO52 10.4
Haematopoietic and lymphoid KOPN8 11.2
Haematopoietic and lymphoid KU812 10.5
Haematopoietic and lymphoid KYO1 9.8
Haematopoietic and lymphoid L1236 9.7
Haematopoietic and lymphoid L363 10.3
Haematopoietic and lymphoid L428 10.5
Haematopoietic and lymphoid L540 10
Haematopoietic and lymphoid LAMA84 10.2
Haematopoietic and lymphoid LOUCY 11.1
Haematopoietic and lymphoid LP1 10.3
Haematopoietic and lymphoid M07E 10
Haematopoietic and lymphoid MC116 10.4
Haematopoietic and lymphoid ME1 10.6
Haematopoietic and lymphoid MEC1 10.5
Haematopoietic and lymphoid MEC2 10.7
Haematopoietic and lymphoid MEG01 10.4
Haematopoietic and lymphoid MHHCALL2 10.9
Haematopoietic and lymphoid MHHCALL3 11.4
Haematopoietic and lymphoid MHHCALL4 11.2
Haematopoietic and lymphoid MINO 10.7
Haematopoietic and lymphoid MJ 10.2
Haematopoietic and lymphoid MM1S 10.5
Haematopoietic and lymphoid MOLM13 10.3
Haematopoietic and lymphoid MOLM16 10.7
Haematopoietic and lymphoid MOLM6 10.2
Haematopoietic and lymphoid MOLP2 9.4
Haematopoietic and lymphoid MOLP8 10.6
Haematopoietic and lymphoid MOLT13 11.4
Haematopoietic and lymphoid MOLT16 10.6
Haematopoietic and lymphoid MOLT4 11
Haematopoietic and lymphoid MONOMAC1 10.3
Haematopoietic and lymphoid MONOMAC6 10
Haematopoietic and lymphoid MOTN1 10.6
Haematopoietic and lymphoid MUTZ5 11.2
Haematopoietic and lymphoid MV411 10.5
Haematopoietic and lymphoid NALM19 11.3
Haematopoietic and lymphoid NALM1 11.1
Haematopoietic and lymphoid NALM6 11.1
Haematopoietic and lymphoid NAMALWA 10.5
Haematopoietic and lymphoid NB4 10.6
Haematopoietic and lymphoid NCIH929 9.7
Haematopoietic and lymphoid NCO2 10
Haematopoietic and lymphoid NOMO1 10.1
Haematopoietic and lymphoid NUDHL1 10.2
Haematopoietic and lymphoid NUDUL1 10.7
Haematopoietic and lymphoid OCIAML2 10.6
Haematopoietic and lymphoid OCIAML3 10.3
Haematopoietic and lymphoid OCIAML5 10.7
Haematopoietic and lymphoid OCILY10 10.3
Haematopoietic and lymphoid OCILY19 11.4
Haematopoietic and lymphoid OCILY3 10.5
Haematopoietic and lymphoid OCIM1 10
Haematopoietic and lymphoid OPM2 10.5
Haematopoietic and lymphoid P12ICHIKAWA 11.1
Haematopoietic and lymphoid P31FUJ 10.1
Haematopoietic and lymphoid P3HR1 10.8
Haematopoietic and lymphoid PCM6 9.9
Haematopoietic and lymphoid PEER 11.2
Haematopoietic and lymphoid PF382 11.3
Haematopoietic and lymphoid PFEIFFER 10.7
Haematopoietic and lymphoid PL21 10.5
Haematopoietic and lymphoid RAJI 10.7
Haematopoietic and lymphoid RCHACV 11.2
Haematopoietic and lymphoid REC1 10.9
Haematopoietic and lymphoid REH 11
Haematopoietic and lymphoid RI1 11.3
Haematopoietic and lymphoid RL 10.3
Haematopoietic and lymphoid RPMI8226 10.1
Haematopoietic and lymphoid RPMI8402 11.3
Haematopoietic and lymphoid RS411 10.8
Haematopoietic and lymphoid SEM 10.6
Haematopoietic and lymphoid SET2 10.6
Haematopoietic and lymphoid SIGM5 10.5
Haematopoietic and lymphoid SKM1 10.4
Haematopoietic and lymphoid SKMM2 9.8
Haematopoietic and lymphoid SR786 10.4
Haematopoietic and lymphoid ST486 11
Haematopoietic and lymphoid SUDHL10 10.8
Haematopoietic and lymphoid SUDHL1 10.4
Haematopoietic and lymphoid SUDHL4 10.9
Haematopoietic and lymphoid SUDHL5 10.9
Haematopoietic and lymphoid SUDHL6 10.7
Haematopoietic and lymphoid SUDHL8 10.7
Haematopoietic and lymphoid SUPB15 11
Haematopoietic and lymphoid SUPHD1 9.6
Haematopoietic and lymphoid SUPM2 9.9
Haematopoietic and lymphoid SUPT11 10.2
Haematopoietic and lymphoid SUPT1 11.1
Haematopoietic and lymphoid TALL1 11.3
Haematopoietic and lymphoid TF1 9.8
Haematopoietic and lymphoid THP1 10.3
Haematopoietic and lymphoid TO175T 9.5
Haematopoietic and lymphoid TOLEDO 10.4
Haematopoietic and lymphoid U266B1 10.4
Haematopoietic and lymphoid U937 9.6
Haematopoietic and lymphoid UT7 10.1
Haematopoietic and lymphoid WSUDLCL2 10.6
Kidney 769P 9.7
Kidney 786O 9.4
Kidney A498 9.3
Kidney A704 8.4
Kidney ACHN 9.8
Kidney BFTC909 9.6
Kidney CAKI1 9.5
Kidney CAKI2 9.6
Kidney CAL54 9.8
Kidney KMRC1 9
Kidney KMRC20 9.6
Kidney KMRC2 9.4
Kidney KMRC3 9.3
Kidney OSRC2 9.2
Kidney RCC10RGB 9.3
Kidney SNU1272 8.8
Kidney SNU349 8.6
Kidney TUHR10TKB 9.4
Kidney TUHR14TKB 9.5
Kidney TUHR4TKB 9.1
Kidney VMRCRCW 9.6
Kidney VMRCRCZ 9.4
Large intestine C2BBE1 10.2
Large intestine CCK81 9.7
Large intestine CL11 9.8
Large intestine CL14 10
Large intestine CL34 10
Large intestine CL40 10.1
Large intestine COLO205 10
Large intestine COLO320 10.1
Large intestine COLO678 10.3
Large intestine CW2 10.4
Large intestine DLD1 10.1
Large intestine GP2D 10.1
Large intestine HCC56 10
Large intestine HCT116 10.3
Large intestine HCT15 10
Large intestine HS675T 8.9
Large intestine HS698T 9.3
Large intestine HT115 9.5
Large intestine HT29 10
Large intestine HT55 10.4
Large intestine KM12 9.5
Large intestine LOVO 10.5
Large intestine LS1034 10.6
Large intestine LS123 9.6
Large intestine LS180 9.8
Large intestine LS411N 10.3
Large intestine LS513 10.2
Large intestine MDST8 10
Large intestine NCIH508 9.6
Large intestine NCIH716 10.1
Large intestine NCIH747 9.9
Large intestine OUMS23 9.4
Large intestine RCM1 9.8
Large intestine RKO 9.7
Large intestine SKCO1 10.4
Large intestine SNU1040 9.5
Large intestine SNU1197 9.4
Large intestine SNU175 10.4
Large intestine SNU283 10.4
Large intestine SNU407 10.6
Large intestine SNU503 9.9
Large intestine SNU61 10.2
Large intestine SNU81 10.5
Large intestine SNUC1 10
Large intestine SNUC2A 9.7
Large intestine SNUC4 10.5
Large intestine SNUC5 9.9
Large intestine SW1116 9.3
Large intestine SW1417 10.3
Large intestine SW1463 10
Large intestine SW403 10.4
Large intestine SW480 9.3
Large intestine SW48 10
Large intestine SW620 10.8
Large intestine SW837 10.2
Large intestine SW948 9.8
Large intestine T84 10.1
Liver ALEXANDERCELLS 9.2
Liver C3A 10
Liver HEP3B217 9.9
Liver HEPG2 9.9
Liver HLE 9.6
Liver HLF 9.6
Liver HUH1 9.8
Liver HUH6 10.4
Liver HUH7 10.1
Liver JHH1 9.6
Liver JHH2 9
Liver JHH4 9.4
Liver JHH5 9.9
Liver JHH6 9.7
Liver JHH7 10.3
Liver LI7 9.8
Liver PLCPRF5 9.3
Liver SKHEP1 9.7
Liver SNU182 9.3
Liver SNU387 9.4
Liver SNU398 10.3
Liver SNU423 9.5
Liver SNU449 9.6
Liver SNU475 9.9
Liver SNU761 9.1
Liver SNU878 9.1
Liver SNU886 9.4
Lung A549 9.8
Lung ABC1 9.7
Lung BEN 9.7
Lung CAL12T 9.9
Lung CALU1 9.2
Lung CALU3 9.9
Lung CALU6 9.9
Lung CHAGOK1 10.3
Lung COLO668 10.5
Lung COLO699 10.2
Lung CORL105 10
Lung CORL23 9.7
Lung CORL24 11
Lung CORL279 9.2
Lung CORL311 10.5
Lung CORL47 10.9
Lung CORL51 10.6
Lung CORL88 11.1
Lung CORL95 10.6
Lung CPCN 10.5
Lung DMS114 10.2
Lung DMS153 10.4
Lung DMS273 10.4
Lung DMS454 10.3
Lung DMS53 9.6
Lung DMS79 9.6
Lung DV90 10
Lung EBC1 10.5
Lung EPLC272H 9.5
Lung HARA 10.2
Lung HCC1171 10
Lung HCC1195 9.1
Lung HCC15 9.5
Lung HCC2279 8.9
Lung HCC2935 10
Lung HCC33 10.5
Lung HCC366 9.9
Lung HCC4006 9.5
Lung HCC44 9.9
Lung HCC78 9.5
Lung HCC827 10
Lung HCC95 9.8
Lung HLC1 10.1
Lung HLFA 8.8
Lung HS229T 9.7
Lung HS618T 9.2
Lung IALM 9.3
Lung KNS62 9.8
Lung LC1F 10
Lung LC1SQSF 10.2
Lung LCLC103H 9.4
Lung LCLC97TM1 9.9
Lung LK2 9.9
Lung LOUNH91 9
Lung LU65 9.8
Lung LU99 10
Lung LUDLU1 10.3
Lung LXF289 9.7
Lung MORCPR 10.1
Lung NCIH1048 10.1
Lung NCIH1092 10.8
Lung NCIH1105 10.6
Lung NCIH1155 10.4
Lung NCIH1184 10.7
Lung NCIH1299 10
Lung NCIH1339 10.4
Lung NCIH1341 9.7
Lung NCIH1355 9.6
Lung NCIH1373 9.6
Lung NCIH1385 9.3
Lung NCIH1395 9.5
Lung NCIH1435 10.1
Lung NCIH1436 10.8
Lung NCIH1437 10.2
Lung NCIH146 10.2
Lung NCIH1563 9.2
Lung NCIH1568 10
Lung NCIH1573 10.2
Lung NCIH1581 10.1
Lung NCIH1618 10.8
Lung NCIH1623 10.3
Lung NCIH1648 9.3
Lung NCIH1650 10.1
Lung NCIH1651 9.5
Lung NCIH1666 9.7
Lung NCIH1693 8.8
Lung NCIH1694 10.2
Lung NCIH1703 9.5
Lung NCIH1734 9.4
Lung NCIH1755 10
Lung NCIH1781 9.9
Lung NCIH1792 10
Lung NCIH1793 9.6
Lung NCIH1836 10.6
Lung NCIH1838 9.4
Lung NCIH1869 9.8
Lung NCIH1876 11
Lung NCIH1915 9.1
Lung NCIH1930 9.9
Lung NCIH1944 9.5
Lung NCIH1963 10.8
Lung NCIH196 9.7
Lung NCIH1975 9.6
Lung NCIH2009 9.6
Lung NCIH2023 9.9
Lung NCIH2029 9.7
Lung NCIH2030 9.9
Lung NCIH2066 10.1
Lung NCIH2081 10.2
Lung NCIH2085 9.9
Lung NCIH2087 9.4
Lung NCIH209 10.4
Lung NCIH2106 10.6
Lung NCIH2110 9.6
Lung NCIH211 10.4
Lung NCIH2122 9.5
Lung NCIH2126 9.6
Lung NCIH2141 10.4
Lung NCIH2170 10.2
Lung NCIH2171 10.1
Lung NCIH2172 10.1
Lung NCIH2196 9.5
Lung NCIH2227 10.1
Lung NCIH2228 9.9
Lung NCIH226 9.7
Lung NCIH2286 10.4
Lung NCIH2291 9.2
Lung NCIH2342 10
Lung NCIH2347 9.3
Lung NCIH23 10.1
Lung NCIH2405 9.9
Lung NCIH2444 8.9
Lung NCIH292 9.7
Lung NCIH322 10
Lung NCIH3255 9.3
Lung NCIH358 10.3
Lung NCIH441 9.4
Lung NCIH446 9.5
Lung NCIH460 9.8
Lung NCIH510 10.2
Lung NCIH520 10.1
Lung NCIH522 9.7
Lung NCIH524 10.4
Lung NCIH526 10.1
Lung NCIH596 9.8
Lung NCIH647 9.4
Lung NCIH650 10.1
Lung NCIH661 9.2
Lung NCIH69 10.2
Lung NCIH727 10.1
Lung NCIH810 9.9
Lung NCIH82 10.3
Lung NCIH838 9.9
Lung NCIH841 9.6
Lung NCIH854 9.8
Lung NCIH889 10.1
Lung PC14 9.5
Lung RERFLCAD1 9.4
Lung RERFLCAD2 9.4
Lung RERFLCAI 9.6
Lung RERFLCKJ 9.1
Lung RERFLCMS 9.4
Lung RERFLCSQ1 9.3
Lung SBC5 9.8
Lung SCLC21H 9.7
Lung SHP77 9.8
Lung SKLU1 9.6
Lung SKMES1 9.5
Lung SQ1 9.4
Lung SW1271 9.9
Lung SW1573 10.2
Lung SW900 9.3
Lung VMRCLCD 9.8
Lung VMRCLCP 10.3
Oesophagus COLO680N 9.4
Oesophagus ECGI10 10.1
Oesophagus KYSE140 9.8
Oesophagus KYSE150 9.8
Oesophagus KYSE180 9.9
Oesophagus KYSE270 9.6
Oesophagus KYSE30 9.2
Oesophagus KYSE410 9.8
Oesophagus KYSE450 9.8
Oesophagus KYSE510 9.9
Oesophagus KYSE520 9.6
Oesophagus KYSE70 9.9
Oesophagus OE19 9.7
Oesophagus OE33 9.4
Oesophagus TE10 10.6
Oesophagus TE11 9.9
Oesophagus TE14 9.8
Oesophagus TE15 10
Oesophagus TE1 9.2
Oesophagus TE4 10.2
Oesophagus TE5 10.3
Oesophagus TE6 9.9
Oesophagus TE8 9.9
Oesophagus TE9 10.1
Oesophagus TT 10.3
Ovary 59M 9
Ovary A2780 10.2
Ovary CAOV3 9.1
Ovary CAOV4 9.5
Ovary COLO704 10.2
Ovary COV318 9.6
Ovary COV362 9.5
Ovary COV434 10
Ovary COV504 9.6
Ovary COV644 9.9
Ovary EFO21 9.7
Ovary EFO27 9.4
Ovary ES2 9.4
Ovary FUOV1 10
Ovary HEYA8 9.5
Ovary HS571T 8.8
Ovary IGROV1 9.5
Ovary JHOC5 9.8
Ovary JHOM1 9.3
Ovary JHOM2B 10
Ovary JHOS2 9.7
Ovary JHOS4 9.4
Ovary KURAMOCHI 9.7
Ovary MCAS 9.7
Ovary NIHOVCAR3 10
Ovary OAW28 10.1
Ovary OAW42 9.9
Ovary OC314 9.9
Ovary OC316 9.9
Ovary ONCODG1 9.8
Ovary OV56 8.8
Ovary OV7 9.5
Ovary OV90 9.8
Ovary OVCAR4 9.1
Ovary OVCAR8 10.1
Ovary OVISE 9.1
Ovary OVK18 9.8
Ovary OVKATE 9.8
Ovary OVMANA 9.3
Ovary OVSAHO 9.2
Ovary OVTOKO 9.3
Ovary RMGI 9.7
Ovary RMUGS 10
Ovary SKOV3 10.2
Ovary SNU119 9.6
Ovary SNU840 10.1
Ovary SNU8 9.2
Ovary TOV112D 10.3
Ovary TOV21G 9.6
Ovary TYKNU 9.7
Pancreas ASPC1 9.3
Pancreas BXPC3 9.7
Pancreas CAPAN1 9.9
Pancreas CAPAN2 9.8
Pancreas CFPAC1 9.3
Pancreas DANG 9.4
Pancreas HPAC 8.9
Pancreas HPAFII 9.7
Pancreas HS766T 9.4
Pancreas HUPT3 9.3
Pancreas HUPT4 9.7
Pancreas KCIMOH1 8.9
Pancreas KLM1 10.5
Pancreas KP2 9.8
Pancreas KP3 9.6
Pancreas KP4 10.3
Pancreas L33 10.1
Pancreas MIAPACA2 9.9
Pancreas PANC0203 9.6
Pancreas PANC0213 9.5
Pancreas PANC0327 9.5
Pancreas PANC0403 9.4
Pancreas PANC0504 10
Pancreas PANC0813 9.6
Pancreas PANC1005 10
Pancreas PANC1 9.5
Pancreas PATU8902 9.8
Pancreas PATU8988S 10.4
Pancreas PATU8988T 10.5
Pancreas PK1 10
Pancreas PK45H 9.5
Pancreas PK59 9.6
Pancreas PL45 10.1
Pancreas PSN1 9.5
Pancreas QGP1 10.1
Pancreas SNU213 9.3
Pancreas SNU324 10.6
Pancreas SNU410 9.5
Pancreas SU8686 9.3
Pancreas SUIT2 10
Pancreas SW1990 9.6
Pancreas T3M4 9.9
Pancreas TCCPAN2 10
Pancreas YAPC 10.3
Pleura ACCMESO1 9
Pleura DM3 8.5
Pleura ISTMES1 9.6
Pleura ISTMES2 9.8
Pleura JL1 9.3
Pleura MPP89 9.2
Pleura MSTO211H 9.9
Pleura NCIH2052 9.4
Pleura NCIH2452 9.6
Pleura NCIH28 9.9
Prostate 22RV1 10.5
Prostate DU145 9.6
Prostate LNCAPCLONEFGC 9.7
Prostate MDAPCA2B 9.6
Prostate NCIH660 10
Prostate PC3 9.1
Prostate VCAP 9.8
Salivary gland A253 9.9
Salivary gland YD15 10.1
Skin A101D 9.4
Skin A2058 9.4
Skin A375 10.1
Skin C32 9.6
Skin CHL1 9.7
Skin CJM 10
Skin COLO679 9.4
Skin COLO741 9.4
Skin COLO783 9.7
Skin COLO792 9.4
Skin COLO800 9.6
Skin COLO818 9.3
Skin COLO829 9.4
Skin COLO849 9.7
Skin G361 9.4
Skin GRM 9.9
Skin HMCB 10.2
Skin HS294T 9.4
Skin HS600T 9.1
Skin HS688AT 9.1
Skin HS695T 9.7
Skin HS839T 9.4
Skin HS852T 9.9
Skin HS895T 8.3
Skin HS934T 9.4
Skin HS936T 9.7
Skin HS939T 9.8
Skin HS940T 9
Skin HS944T 9.4
Skin HT144 9.8
Skin IGR1 9.7
Skin IGR37 9.8
Skin IGR39 10.1
Skin IPC298 9.3
Skin K029AX 9.4
Skin LOXIMVI 9.8
Skin MALME3M 9.2
Skin MDAMB435S 9.3
Skin MELHO 9.5
Skin MELJUSO 9.6
Skin MEWO 10.2
Skin RPMI7951 10.1
Skin RVH421 9.5
Skin SH4 9.9
Skin SKMEL1 9.4
Skin SKMEL24 9
Skin SKMEL28 9.3
Skin SKMEL2 9.6
Skin SKMEL30 9.5
Skin SKMEL31 9.1
Skin SKMEL3 9.5
Skin SKMEL5 9.3
Skin UACC257 9.4
Skin UACC62 9.4
Skin WM115 9.5
Skin WM1799 9.9
Skin WM2664 9.5
Skin WM793 9.8
Skin WM88 9.7
Skin WM983B 9.9
Small intestine HUTU80 10.1
Soft tissue A204 9.6
Soft tissue G401 10.3
Soft tissue G402 9.7
Soft tissue GCT 9.7
Soft tissue HS729 9.4
Soft tissue HT1080 10
Soft tissue KYM1 9.6
Soft tissue MESSA 9.9
Soft tissue RD 9.9
Soft tissue RH30 9.8
Soft tissue RH41 10.4
Soft tissue RKN 10
Soft tissue S117 10.2
Soft tissue SJRH30 10
Soft tissue SKLMS1 9.3
Soft tissue SKUT1 9.6
Soft tissue TE125T 8.9
Soft tissue TE159T 8.9
Soft tissue TE441T 10.5
Soft tissue TE617T 10.2
Stomach 2313287 10.1
Stomach AGS 10.2
Stomach AZ521 10.1
Stomach ECC10 10
Stomach ECC12 10.5
Stomach FU97 10
Stomach GCIY 9.3
Stomach GSS 10.6
Stomach GSU 10
Stomach HGC27 10.3
Stomach HS746T 9.3
Stomach HUG1N 9.8
Stomach IM95 9.8
Stomach KATOIII 9.9
Stomach KE39 9.8
Stomach LMSU 10.3
Stomach MKN1 9.3
Stomach MKN45 10.2
Stomach MKN74 9.5
Stomach MKN7 9.4
Stomach NCCSTCK140 9.7
Stomach NCIN87 10.2
Stomach NUGC2 9.9
Stomach NUGC3 9.5
Stomach NUGC4 9.9
Stomach OCUM1 10
Stomach RERFGC1B 10.1
Stomach SH10TC 9.1
Stomach SNU16 9.7
Stomach SNU1 10.5
Stomach SNU216 10.1
Stomach SNU520 10.2
Stomach SNU5 9.8
Stomach SNU601 9.8
Stomach SNU620 10
Stomach SNU668 9.8
Stomach SNU719 10.3
Stomach TGBC11TKB 9.9
Thyroid 8305C 9.6
Thyroid 8505C 9.7
Thyroid BCPAP 8.7
Thyroid BHT101 9
Thyroid CAL62 9.5
Thyroid CGTHW1 9.4
Thyroid FTC133 9.7
Thyroid FTC238 9.5
Thyroid ML1 9.5
Thyroid SW579 9.9
Thyroid TT2609C02 9.9
Thyroid TT 9.8
Upper aerodigestive tract BHY 9.2
Upper aerodigestive tract BICR16 9.2
Upper aerodigestive tract BICR18 9.8
Upper aerodigestive tract BICR22 9.3
Upper aerodigestive tract BICR31 9.9
Upper aerodigestive tract BICR56 8.9
Upper aerodigestive tract BICR6 9.7
Upper aerodigestive tract CAL27 9.5
Upper aerodigestive tract CAL33 9.2
Upper aerodigestive tract DETROIT562 9.7
Upper aerodigestive tract FADU 10.4
Upper aerodigestive tract HS840T 9.3
Upper aerodigestive tract HSC2 9.2
Upper aerodigestive tract HSC3 9.7
Upper aerodigestive tract HSC4 9.9
Upper aerodigestive tract PECAPJ15 10.2
Upper aerodigestive tract PECAPJ34CLONEC12 10.2
Upper aerodigestive tract PECAPJ41CLONED2 9.6
Upper aerodigestive tract PECAPJ49 10
Upper aerodigestive tract SCC15 9.2
Upper aerodigestive tract SCC25 9.6
Upper aerodigestive tract SCC4 9.5
Upper aerodigestive tract SCC9 9.6
Upper aerodigestive tract SNU1076 9.2
Upper aerodigestive tract SNU1214 9.9
Upper aerodigestive tract SNU46 9.8
Upper aerodigestive tract SNU899 9.6
Upper aerodigestive tract YD10B 9.6
Upper aerodigestive tract YD38 9.5
Upper aerodigestive tract YD8 9.8
Urinary tract 5637 9.4
Urinary tract 639V 10.3
Urinary tract 647V 10.1
Urinary tract BC3C 10
Urinary tract BFTC905 10.2
Urinary tract CAL29 9.9
Urinary tract HS172T 9
Urinary tract HT1197 9.8
Urinary tract HT1376 9.8
Urinary tract J82 9.4
Urinary tract JMSU1 10.2
Urinary tract KMBC2 10.8
Urinary tract KU1919 9.9
Urinary tract RT11284 10.3
Urinary tract RT112 9.7
Urinary tract RT4 10.1
Urinary tract SCABER 9.6
Urinary tract SW1710 9.7
Urinary tract SW780 10
Urinary tract T24 10
Urinary tract TCCSUP 10.3
Urinary tract UMUC1 9.6
Urinary tract UMUC3 9.7
Urinary tract VMCUB1 9.8
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 16.8
Adrenal gland 18.9
Appendix 29.3
Bone marrow 24.4
Breast 22.7
Cerebral cortex 28.8
Cervix, uterine 29.3
Colon 19.4
Duodenum 18
Endometrium 35
Epididymis 18.7
Esophagus 20
Fallopian tube 31
Gallbladder 24.4
Heart muscle 10.5
Kidney 19.5
Liver 9.7
Lung 24.9
Lymph node 39.3
Ovary 27.3
Pancreas 3.7
Parathyroid gland 57.7
Placenta 28.7
Prostate 27.5
Rectum 23.2
Salivary gland 7.6
Seminal vesicle 23.8
Skeletal muscle 10.7
Skin 27.5
Small intestine 19.4
Smooth muscle 28.7
Spleen 33.8
Stomach 17.1
Testis 18.5
Thyroid gland 32.3
Tonsil 32.3
Urinary bladder 22.5
> Text Mining based Expression
 
PMID Expression Cancer Evidence
26639241underexpressionHepatocellular CarcinomaApanel of 21 genes, including TRADD, PSMB10, THAP11, CTCF and ESRP2, were significantly downregulated in HCCs with 16q22.1 loss compared to those without the loss.
26125810overexpressionCervical CarcinomaCTCF expression was significantly higher in carcinoma groups compared with LSIL, HSIL, and negative for intraepithelial lesion or malignancy groups.
25499215aberrant expressionProstate CarcinomaIn the first detailed analysis in cancer, a marked loss of CHD8 expression and increased BORIS/CTCF ratio indicate frequent disruption of CTCF and its effector genes in PCa.
24842653underexpressionBreast CarcinomamRNA expression of CTCF and SIRT6 in invasive tumors showed a lower level than that in paired normal tissues (p=0.008 and p=0.030, respectively).
24649078underexpressionBreast CarcinomaThe MCF7 cells exhibited basal transcription of CTCF, which was significantly downregulated to 0.68 by 1 μM E2; basal or E2-regulated transcription of CTCFL was not detected.
24393203overexpressionChildhood Acute Lymphoblastic LeukemiaMicroarray analysis of samples from 100 Chinese children with ALL revealed the up-regulation of CTCF (CCCTC binding factor).
23390377underexpressionOvarian CarcinomaIn contrast, CTCF is downregulated in EOC, and the ratio of BORIS sf1, sf2, and sf6 isoform families as a function of CTCF is elevated in hypomethylated tumors.
28648147altered expressionBreast CarcinomaPrevious studies revealed that various diseases including breast cancer were developed from aberrant expression of CTCF itself or their target genes. In this review, we will describe dysfunction of CTCF that induces tumorigenesis and summarize the functional roles of CTCF in breast cancer.
27638884UnderexpressionBreast CarcinomaFurthermore, the depletion of CTCF facilitates the expression of target genes associated with cell division and increases the rate of breast cancer cell proliferation.
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
Cancer Full Name # Sample R P % Loss % Neutral % Gain Status
BLCABladder urothelial carcinoma4040.5023.51e-2725.548.526Neutral
BRCABreast invasive carcinoma10750.3942.58e-4163.2288.8Loss
CESCCervical and endocervical cancers2920.5456.08e-2416.868.814.4Neutral
COADColon adenocarcinoma4490.2326.41e-076.970.622.5Neutral
ESCAEsophageal carcinoma1830.5121.25e-1328.443.228.4Neutral
GBMGlioblastoma multiforme1470.3723.41e-0620.475.54.1Neutral
HNSCHead and Neck squamous cell carcinoma5140.2892.36e-1116.561.322.2Neutral
KIRCKidney renal clear cell carcinoma5250.2648.39e-10477.318.7Neutral
KIRPKidney renal papillary cell carcinoma2880.4113.82e-132.445.552.1Gain
LAMLAcute Myeloid Leukemia1660.3027.5e-053970Neutral
LGGBrain Lower Grade Glioma5130.2771.68e-104.791.63.7Neutral
LIHCLiver hepatocellular carcinoma3640.4325.44e-1842.651.95.5Loss
LUADLung adenocarcinoma5120.3292.12e-1429.550.420.1Neutral
LUSCLung squamous cell carcinoma4980.4045.9e-2135.345.219.5Loss
OVOvarian serous cystadenocarcinoma3000.6335.1e-3579.3164.7Loss
PAADPancreatic adenocarcinoma1770.3646.32e-076.879.713.6Neutral
PCPGPheochromocytoma and Paraganglioma1620.2010.01043.791.44.9Neutral
PRADProstate adenocarcinoma4910.4311.3e-2326.971.71.4Neutral
READRectum adenocarcinoma1640.3843.89e-0711.665.223.2Neutral
SARCSarcoma2550.4261.15e-1252.240.47.5Loss
SKCMSkin Cutaneous Melanoma3670.4232.3e-1728.357.813.9Neutral
STADStomach adenocarcinoma4130.4122.36e-1826.960.312.8Neutral
TGCTTesticular Germ Cell Tumors1500.5122.17e-113254.713.3Neutral
THCAThyroid carcinoma4970.2082.96e-060.896.62.6Neutral
THYMThymoma1190.535.91e-1010.987.41.7Neutral
UCECUterine Corpus Endometrial Carcinoma5370.3581.19e-1729.867.42.8Neutral
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
BLCABladder urothelial carcinoma-0.271.85e-0817408-0.0270.267NS/NA
BRCABreast invasive carcinoma-0.2761.43e-16837850.0020.0136NS/NA
CESCCervical and endocervical cancers-0.234.79e-053306NANANS/NA
COADColon adenocarcinoma-0.2843.31e-07192970.0190.000211NS/NA
ESCAEsophageal carcinoma-0.2470.0005289185NANANS/NA
GBMGlioblastoma multiforme-0.2780.0252164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.2421.22e-08205220.0010.000985NS/NA
KIRCKidney renal clear cell carcinoma-0.1180.0293243190.0150.0246NS/NA
KIRPKidney renal papillary cell carcinoma-0.2596.58e-06232750.0010.607NS/NA
LAMLAcute Myeloid Leukemia-0.1330.08390170NANANS/NA
LGGBrain Lower Grade Glioma-0.1170.006920530NANANS/NA
LIHCLiver hepatocellular carcinoma-0.170.000528413730.0030.486NS/NA
LUADLung adenocarcinoma-0.1450.00153214560.0040.159NS/NA
LUSCLung squamous cell carcinoma-0.2075.02e-058370NANANS/NA
OVOvarian serous cystadenocarcinoma-0.9170.0013109NANANS/NA
PAADPancreatic adenocarcinoma-0.1710.02074179NANANS/NA
PCPGPheochromocytoma and Paraganglioma-0.1150.1183184NANANS/NA
PRADProstate adenocarcinoma-0.3187.31e-14354980.0140.000215NS/NA
READRectum adenocarcinoma-0.2170.0295299NANANS/NA
SARCSarcoma-0.2631.63e-050263NANANS/NA
SKCMSkin Cutaneous Melanoma-0.317.45e-121471NANANS/NA
STADStomach adenocarcinoma-0.1880.0002630372NANANS/NA
TGCTTesticular Germ Cell Tumors-0.2330.003490156NANANS/NA
THCAThyroid carcinoma-0.1550.000245050900.268NS/NA
THYMThymoma-0.260.003862120NANANS/NA
UCECUterine Corpus Endometrial Carcinoma-0.1640.00039734431-0.0130.629NS/NA
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Level Level Name
Adrenal gland 3 High
Appendix 3 High
Bone marrow 3 High
Breast 3 High
Bronchus 3 High
Caudate 2 Medium
Cerebellum 3 High
Cerebral cortex 3 High
Cervix, uterine 3 High
Colon 3 High
Duodenum 3 High
Endometrium 3 High
Epididymis 3 High
Esophagus 3 High
Fallopian tube 3 High
Gallbladder 3 High
Heart muscle 3 High
Hippocampus 2 Medium
Kidney 3 High
Liver 1 Low
Lung 3 High
Lymph node 3 High
Nasopharynx 3 High
Oral mucosa 2 Medium
Ovary 3 High
Pancreas 3 High
Parathyroid gland 3 High
Placenta 3 High
Prostate 2 Medium
Rectum 3 High
Salivary gland 3 High
Seminal vesicle 2 Medium
Skeletal muscle 3 High
Skin 3 High
Small intestine 3 High
Smooth muscle 3 High
Soft tissue 2 Medium
Spleen 3 High
Stomach 3 High
Testis 3 High
Thyroid gland 3 High
Tonsil 3 High
Urinary bladder 3 High
Vagina 3 High
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
Cancer Full Name # Patients P Value (Kruskal-Wallis) Association Source
BLCABladder urothelial carcinoma1280.685NS24476821
BRCABreast invasive carcinoma5215.44e-07Significant23000897
COADColon adenocarcinoma1490.553NS22810696
GBMGlioblastoma multiforme1571.45e-06Significant26824661
HNSCHead and Neck squamous cell carcinoma2790.0396Significant25631445
KIRPKidney renal papillary cell carcinoma1610.48NS26536169
LGGBrain Lower Grade Glioma5131.9e-21Significant26824661
LUADLung adenocarcinoma2302.21e-07Significant25079552
LUSCLung squamous cell carcinoma1780.112NS22960745
OVOvarian serous cystadenocarcinoma2870.0203Significant21720365
PRADProstate adenocarcinoma3330.00934Significant26544944
READRectum adenocarcinoma670.00986Significant22810696
SKCMSkin Cutaneous Melanoma3150.0409Significant26091043
STADStomach adenocarcinoma2773.52e-07Significant25079317
THCAThyroid carcinoma3910.585NS25417114
UCECUterine Corpus Endometrial Carcinoma2320.0169Significant23636398
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
BLCABladder urothelial carcinoma405 0.7590.192NS
BRCABreast invasive carcinoma1079 1.1480.55NS
CESCCervical and endocervical cancers291 1.0260.941NS
COADColon adenocarcinoma439 0.8670.618NS
ESCAEsophageal carcinoma184 0.9530.879NS
GBMGlioblastoma multiforme158 0.8470.509NS
HNSCHead and Neck squamous cell carcinoma518 0.9060.623NS
KIRCKidney renal clear cell carcinoma531 0.2862.65e-08Longer
KIRPKidney renal papillary cell carcinoma287 0.910.825NS
LAMLAcute Myeloid Leukemia149 0.6850.202NS
LGGBrain Lower Grade Glioma511 0.3671.12e-05Longer
LIHCLiver hepatocellular carcinoma365 1.190.478NS
LUADLung adenocarcinoma502 1.2950.2NS
LUSCLung squamous cell carcinoma494 0.990.958NS
OVOvarian serous cystadenocarcinoma303 0.8320.372NS
PAADPancreatic adenocarcinoma177 2.0140.017Shorter
PCPGPheochromocytoma and Paraganglioma179 2.1820.514NS
PRADProstate adenocarcinoma497 2622506185.6460.0362Shorter
READRectum adenocarcinoma159 0.7050.545NS
SARCSarcoma259 1.3430.32NS
SKCMSkin Cutaneous Melanoma459 1.1540.465NS
STADStomach adenocarcinoma388 0.9920.972NS
TGCTTesticular Germ Cell Tumors134 594299980.1560.317NS
THCAThyroid carcinoma500 1.4770.592NS
THYMThymoma119 00.0116Longer
UCECUterine Corpus Endometrial Carcinoma543 0.9270.79NS
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
BLCABladder urothelial carcinoma406 -0.010.841NS
BRCABreast invasive carcinoma1071 0.0360.233NS
CESCCervical and endocervical cancers167 -0.070.369NS
COADColon adenocarcinoma445 0.0150.746NS
ESCAEsophageal carcinoma162 0.0080.92NS
HNSCHead and Neck squamous cell carcinoma448 -0.0540.255NS
KIRCKidney renal clear cell carcinoma531 -0.1510.000471Lower
KIRPKidney renal papillary cell carcinoma260 0.0870.163NS
LIHCLiver hepatocellular carcinoma347 0.0660.221NS
LUADLung adenocarcinoma507 0.080.0729NS
LUSCLung squamous cell carcinoma497 0.0340.445NS
OVOvarian serous cystadenocarcinoma302 -0.0620.286NS
PAADPancreatic adenocarcinoma176 0.0740.329NS
READRectum adenocarcinoma156 0.0360.653NS
SKCMSkin Cutaneous Melanoma410 -0.1110.0246Lower
STADStomach adenocarcinoma392 0.0340.503NS
TGCTTesticular Germ Cell Tumors81 0.1380.219NS
THCAThyroid carcinoma499 -0.0320.482NS
UCECUterine Corpus Endometrial Carcinoma501 -0.0240.588NS
> Grade
 

  Association between expresson and grade.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
CESCCervical and endocervical cancers272 0.0070.904NS
HNSCHead and Neck squamous cell carcinoma498 0.040.378NS
KIRCKidney renal clear cell carcinoma525 -0.1650.000145Lower
LGGBrain Lower Grade Glioma514 -0.0440.323NS
LIHCLiver hepatocellular carcinoma366 -0.0150.78NS
OVOvarian serous cystadenocarcinoma296 -0.0280.626NS
PAADPancreatic adenocarcinoma176 0.0060.939NS
STADStomach adenocarcinoma406 -0.0590.239NS
UCECUterine Corpus Endometrial Carcinoma534 0.0860.0467Higher
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for CTCF.
Summary
SymbolCTCF
NameCCCTC-binding factor
Aliases 11 zinc finger transcriptional repressor; MRD21; 11-zinc finger protein; CTCFL paralog; Transcriptional repr ......
Location16q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
PMID Cancer Hierarchy Gene Relation to CR Evidence
24393203Childhood Acute Lymphoblastic LeukemiaupstreamNF-κBregulationFurthermore, inhibition or activation of the nuclear factor-kappa B (NF-κB) pathway resulted in marked variations in the levels of CTCF mRNA and protein in leukemic cells, indicating that CTCF may be involved downstream of the NF-κB pathway.
24130125Endometrial CarcinomapartnerBORISparalogBORIS, a paralogue of the transcription factor CTCF, is a member of the cancer-testis antigen (CT) family.
23390377Ovarian CarcinomapartnerBORISparalogBORIS is the only known paralog of CTCF, a gene intimately involved in genomic imprinting, chromatin insulation, and nuclear regulation.