CR2Cancer

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF03344 Daxx N-terminal Rassf1C-interacting domain

Function

Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as histone chaperone that facilitates deposition of histone H3.3. Acts as targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response (PubMed:15016915).

Classification

Class	Modification	Substrate	Product	PubMed
#	#	H3.3	#	23075851

> Gene Ontology [ TOP ]
Biological Process	GO:0000187 activation of MAPK activity GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006338 chromatin remodeling GO:0007254 JNK cascade GO:0007257 activation of JUN kinase activity GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0009755 hormone-mediated signaling pathway GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031098 stress-activated protein kinase signaling cascade GO:0031396 regulation of protein ubiquitination GO:0031497 chromatin assembly GO:0032147 activation of protein kinase activity GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033674 positive regulation of kinase activity GO:0034728 nucleosome organization GO:0043401 steroid hormone mediated signaling pathway GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043506 regulation of JUN kinase activity GO:0043507 positive regulation of JUN kinase activity GO:0045860 positive regulation of protein kinase activity GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0048545 response to steroid hormone GO:0051403 stress-activated MAPK cascade GO:0065004 protein-DNA complex assembly GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070997 neuron death GO:0071103 DNA conformation change GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071824 protein-DNA complex subunit organization GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0097191 extrinsic apoptotic signaling pathway GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1903320 regulation of protein modification by small protein conjugation or removal
Molecular Function	GO:0002039 p53 binding GO:0003714 transcription corepressor activity GO:0005057 receptor signaling protein activity GO:0008047 enzyme activator activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0031072 heat shock protein binding GO:0031625 ubiquitin protein ligase binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0042393 histone binding GO:0044389 ubiquitin-like protein ligase binding GO:0047485 protein N-terminus binding GO:0050681 androgen receptor binding GO:0051427 hormone receptor binding
Cellular Component	GO:0000775 chromosome, centromeric region GO:0016604 nuclear body GO:0016605 PML body GO:0070603 SWI/SNF superfamily-type complex GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway hsa04210 Apoptosis
Reactome	R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804757: Regulation of TP53 Degradation R-HSA-6806003: Regulation of TP53 Expression and Degradation R-HSA-3700989: Transcriptional Regulation by TP53

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3625708	c.1262G>A	p.G421E	Substitution - Missense	Skin
COSM4943323	c.223A>G	p.K75E	Substitution - Missense	Liver
COSM5548690	c.444C>A	p.A148A	Substitution - coding silent	Prostate
COSM4804521	c.1252-2A>G	p.?	Unknown	Liver
COSM3625713	c.260T>A	p.F87Y	Substitution - Missense	Skin
COSM85806	c.1766_1766delC	p.R590fs*12	Deletion - Frameshift	Pancreas
COSM1443795	c.9C>T	p.T3T	Substitution - coding silent	Large_intestine
COSM4139284	c.991G>T	p.D331Y	Substitution - Missense	Pancreas
COSM367420	c.1235C>T	p.S412F	Substitution - Missense	Lung
COSM4804521	c.1252-2A>G	p.?	Unknown	Liver
COSM4153298	c.603G>A	p.E201E	Substitution - coding silent	Ovary
COSM126645	c.2135C>G	p.S712*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM5795542	c.2051C>T	p.T684M	Substitution - Missense	Breast
COSM1496343	c.1751C>T	p.T584M	Substitution - Missense	Kidney
COSM3697409	c.2210C>G	p.S737*	Substitution - Nonsense	Large_intestine
COSM5825529	c.982C>T	p.R328C	Substitution - Missense	Pancreas
COSM4006466	c.84C>T	p.L28L	Substitution - coding silent	Urinary_tract
COSM1443793	c.135T>C	p.H45H	Substitution - coding silent	Large_intestine
COSM1078015	c.1994C>T	p.T665I	Substitution - Missense	Endometrium
COSM239519	c.1826_1827insT	p.S610fs*48	Insertion - Frameshift	Prostate
COSM4425258	c.1702G>C	p.E568Q	Substitution - Missense	Oesophagus
COSM4472351	c.1742C>T	p.S581F	Substitution - Missense	Skin
COSM1487661	c.1142T>G	p.M381R	Substitution - Missense	Breast
COSM85805	c.916C>T	p.R306*	Substitution - Nonsense	Pancreas
COSM5758516	c.597G>A	p.V199V	Substitution - coding silent	Bone
COSM4992716	c.71C>T	p.P24L	Substitution - Missense	Skin
COSM5611778	c.2067C>A	p.P689P	Substitution - coding silent	Adrenal_gland
COSM4445252	c.1669_1669delC	p.L557fs*13	Deletion - Frameshift	Adrenal_gland
COSM3873166	c.1584G>A	p.V528V	Substitution - coding silent	Stomach
COSM4777514	c.1286C>T	p.S429F	Substitution - Missense	Breast
COSM5019541	c.2112C>T	p.A704A	Substitution - coding silent	Soft_tissue
COSM5996984	c.1466-3C>A	p.?	Unknown	Prostate
COSM234593	c.292C>T	p.L98L	Substitution - coding silent	Skin
COSM3625712	c.463C>T	p.P155S	Substitution - Missense	Skin
COSM4557546	c.696G>C	p.L232L	Substitution - coding silent	Skin
COSM3949097	c.375C>T	p.V125V	Substitution - coding silent	Lung
COSM5019618	c.1137T>C	p.Y379Y	Substitution - coding silent	Soft_tissue
COSM5763025	c.208-1G>A	p.?	Unknown	Pancreas
COSM4770128	c.1705C>G	p.L569V	Substitution - Missense	Biliary_tract
COSM1496342	c.1244C>T	p.S415F	Substitution - Missense	Kidney
COSM85808	c.889G>C	p.A297P	Substitution - Missense	Pancreas
COSM85801	c.1976_1976delA	p.N659fs*36	Deletion - Frameshift	Pancreas
COSM5692181	c.977A>T	p.E326V	Substitution - Missense	Soft_tissue
COSM158738	c.1111C>T	p.R371W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3734250	c.707T>A	p.F236Y	Substitution - Missense	Pancreas
COSM1078016	c.1849G>A	p.V617I	Substitution - Missense	Endometrium
COSM4625775	c.276G>A	p.Q92Q	Substitution - coding silent	Large_intestine
COSM483941	c.1353G>A	p.E451E	Substitution - coding silent	Kidney
COSM4837982	c.1095G>C	p.R365R	Substitution - coding silent	Cervix
COSM483942	c.700C>T	p.R234C	Substitution - Missense	Kidney
COSM4963480	c.979C>T	p.R327*	Substitution - Nonsense	Pancreas
COSM3830258	c.2185G>A	p.D729N	Substitution - Missense	Breast
COSM379376	c.1728G>A	p.L576L	Substitution - coding silent	Lung
COSM2151099	c.1759T>C	p.S587P	Substitution - Missense	Central_nervous_system
COSM421364	c.1897C>T	p.R633W	Substitution - Missense	Urinary_tract
COSM1078018	c.1365G>T	p.E455D	Substitution - Missense	Endometrium
COSM5575961	c.1186G>T	p.A396S	Substitution - Missense	Stomach
COSM742335	c.1168G>A	p.E390K	Substitution - Missense	Lung
COSM4771406	c.1442A>C	p.D481A	Substitution - Missense	Breast
COSM5952661	c.778C>T	p.R260C	Substitution - Missense	Oesophagus
COSM5498934	c.397G>A	p.V133I	Substitution - Missense	Biliary_tract
COSM5019618	c.1137T>C	p.Y379Y	Substitution - coding silent	Soft_tissue
COSM5825415	c.413C>G	p.S138*	Substitution - Nonsense	Pancreas
COSM5020839	c.1914A>G	p.Q638Q	Substitution - coding silent	Soft_tissue
COSM4586655	c.444C>T	p.A148A	Substitution - coding silent	Bone
COSM5824754	c.310G>T	p.E104*	Substitution - Nonsense	Pancreas
COSM5019618	c.1137T>C	p.Y379Y	Substitution - coding silent	Soft_tissue
COSM160333	c.452C>A	p.T151N	Substitution - Missense	Breast
COSM3662438	c.1341G>A	p.E447E	Substitution - coding silent	Liver
COSM4586654	c.688C>G	p.R230G	Substitution - Missense	Bone
COSM1443794	c.42C>T	p.D14D	Substitution - coding silent	Large_intestine
COSM4477591	c.2131C>T	p.H711Y	Substitution - Missense	Skin
COSM5357385	c.1486C>A	p.P496T	Substitution - Missense	Large_intestine
COSM85813	c.166A>T	p.K56*	Substitution - Nonsense	Pancreas
COSM483941	c.1353G>A	p.E451E	Substitution - coding silent	Central_nervous_system
COSM14038	c.915C>T	p.P305P	Substitution - coding silent	Skin
COSM5014588	c.2003G>A	p.S668N	Substitution - Missense	Kidney
COSM1443796	c.8C>T	p.T3I	Substitution - Missense	Large_intestine
COSM1078020	c.1315G>T	p.D439Y	Substitution - Missense	Endometrium
COSM5019618	c.1137T>C	p.Y379Y	Substitution - coding silent	Soft_tissue
COSM3873175	c.181C>T	p.L61L	Substitution - coding silent	Stomach
COSM85807	c.389T>G	p.L130R	Substitution - Missense	Pancreas
COSM3430544	c.43G>A	p.E15K	Substitution - Missense	Large_intestine
COSM4169710	c.?	p.A47fs*92	Unknown	Adrenal_gland
COSM3662438	c.1341G>A	p.E447E	Substitution - coding silent	Liver
COSM3873170	c.1356A>G	p.E452E	Substitution - coding silent	Stomach
COSM1078024	c.286C>T	p.H96Y	Substitution - Missense	Endometrium
COSM5430626	c.264C>G	p.L88L	Substitution - coding silent	Oesophagus
COSM1078017	c.1378G>T	p.D460Y	Substitution - Missense	Endometrium
COSM4963480	c.979C>T	p.R327*	Substitution - Nonsense	Pancreas
COSM4445253	c.?	p.?	Unknown	Soft_tissue
COSM85802	c.1980_1980delG	p.K662fs*33	Deletion - Frameshift	Pancreas
COSM1443782	c.2016C>T	p.P672P	Substitution - coding silent	Large_intestine
COSM3349824	c.495C>A	p.S165S	Substitution - coding silent	Large_intestine
COSM4972097	c.141_150del10	p.R48fs*93	Deletion - Frameshift	Thyroid
COSM483941	c.1353G>A	p.E451E	Substitution - coding silent	Stomach
COSM4891184	c.996C>G	p.L332L	Substitution - coding silent	Upper_aerodigestive_tract
COSM3734250	c.707T>A	p.F236Y	Substitution - Missense	Pancreas
COSM5020839	c.1914A>G	p.Q638Q	Substitution - coding silent	Soft_tissue
COSM4609819	c.1306_1307delGA	p.D436fs*1	Deletion - Frameshift	Adrenal_gland
COSM483941	c.1353G>A	p.E451E	Substitution - coding silent	Large_intestine
COSM483943	c.199T>A	p.F67I	Substitution - Missense	Kidney
COSM5674935	c.916C>G	p.R306G	Substitution - Missense	Soft_tissue
COSM3921526	c.122C>T	p.S41F	Substitution - Missense	Skin
COSM4676235	c.92C>T	p.A31V	Substitution - Missense	Large_intestine
COSM158738	c.1111C>T	p.R371W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4992714	c.2113C>T	p.R705W	Substitution - Missense	Skin
COSM3349831	c.10G>A	p.A4T	Substitution - Missense	Large_intestine
COSM3411007	c.1991G>T	p.C664F	Substitution - Missense	Central_nervous_system
COSM3873167	c.1579A>G	p.I527V	Substitution - Missense	Stomach
COSM94119	c.608G>A	p.R203Q	Substitution - Missense	Prostate
COSM3873172	c.767G>A	p.R256H	Substitution - Missense	Stomach
COSM85924	c.925_926insAGT	p.L309>QF	Complex - insertion inframe	Pancreas
COSM4161068	c.484A>C	p.T162P	Substitution - Missense	Thyroid
COSM4771406	c.1442A>C	p.D481A	Substitution - Missense	Breast
COSM3777569	c.810C>T	p.R270R	Substitution - coding silent	Urinary_tract
COSM1078023	c.603G>T	p.E201D	Substitution - Missense	Endometrium
COSM84971	c.458A>G	p.N153S	Substitution - Missense	Pancreas
COSM360168	c.2002A>T	p.S668C	Substitution - Missense	Lung
COSM742334	c.749G>A	p.G250D	Substitution - Missense	Lung
COSM4452013	c.1500A>T	p.L500L	Substitution - coding silent	Skin
COSM144228	c.712C>T	p.R238*	Substitution - Nonsense	Central_nervous_system
COSM5905661	c.494C>T	p.S165F	Substitution - Missense	Skin
COSM5758517	c.540G>A	p.R180R	Substitution - coding silent	Bone
COSM77557	c.143G>C	p.R48T	Substitution - Missense	Ovary
COSM144228	c.712C>T	p.R238*	Substitution - Nonsense	Stomach
COSM4676233	c.2025C>A	p.S675S	Substitution - coding silent	Large_intestine
COSM3873169	c.1414G>A	p.E472K	Substitution - Missense	Stomach
COSM3349831	c.10G>A	p.A4T	Substitution - Missense	Large_intestine
COSM5575961	c.1186G>T	p.A396S	Substitution - Missense	Oesophagus
COSM3349815	c.788G>A	p.R263H	Substitution - Missense	Stomach
COSM141156	c.274C>G	p.Q92E	Substitution - Missense	Upper_aerodigestive_tract
COSM5019618	c.1137T>C	p.Y379Y	Substitution - coding silent	Soft_tissue
COSM5019618	c.1137T>C	p.Y379Y	Substitution - coding silent	Soft_tissue
COSM4676234	c.149G>A	p.S50N	Substitution - Missense	Large_intestine
COSM3873168	c.1577G>A	p.R526H	Substitution - Missense	Stomach
COSM1443783	c.1884_1885insC	p.C629fs*29	Insertion - Frameshift	Large_intestine
COSM84971	c.458A>G	p.N153S	Substitution - Missense	Pancreas
COSM5759578	c.489C>A	p.H163Q	Substitution - Missense	Bone
COSM3873174	c.284C>T	p.A95V	Substitution - Missense	Stomach
COSM4847683	c.2105C>T	p.S702F	Substitution - Missense	Cervix
COSM3873173	c.355C>T	p.R119W	Substitution - Missense	Stomach
COSM5457257	c.281G>A	p.R94H	Substitution - Missense	Stomach
COSM5902299	c.343C>T	p.R115W	Substitution - Missense	Skin
COSM5944151	c.1407G>C	p.Q469H	Substitution - Missense	Bone
COSM3674678	c.1819A>G	p.M607V	Substitution - Missense	Prostate
COSM5611666	c.559C>T	p.Q187*	Substitution - Nonsense	Adrenal_gland
COSM158738	c.1111C>T	p.R371W	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4139283	c.1251+5G>A	p.?	Unknown	Pancreas
COSM4767512	c.1084C>T	p.R362W	Substitution - Missense	Biliary_tract
COSM5568493	c.1550C>A	p.S517Y	Substitution - Missense	Prostate
COSM4625774	c.886G>A	p.A296T	Substitution - Missense	Large_intestine
COSM483941	c.1353G>A	p.E451E	Substitution - coding silent	Prostate
COSM5019618	c.1137T>C	p.Y379Y	Substitution - coding silent	Soft_tissue
COSM4778171	c.1492T>C	p.S498P	Substitution - Missense	Prostate
COSM5802840	c.73T>C	p.S25P	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3873171	c.1191G>A	p.R397R	Substitution - coding silent	Stomach
COSM85811	c.1219_1219delG	p.D407fs*121	Deletion - Frameshift	Pancreas
COSM3625710	c.1220A>T	p.D407V	Substitution - Missense	Skin
COSM1643029	c.1820T>C	p.M607T	Substitution - Missense	Stomach
COSM3349831	c.10G>A	p.A4T	Substitution - Missense	Large_intestine
COSM5880383	c.1457C>G	p.A486G	Substitution - Missense	Soft_tissue
COSM85804	c.211_211delC	p.E72fs*72	Deletion - Frameshift	Pancreas
COSM3394124	c.1384G>T	p.E462*	Substitution - Nonsense	Pancreas
COSM14015	c.1651C>T	p.Q551*	Substitution - Nonsense	Skin
COSM85810	c.306_309delGGCG	p.A103fs*40	Deletion - Frameshift	Pancreas
COSM85809	c.2042_2043insT	p.S682fs*59	Insertion - Frameshift	Pancreas
COSM252462	c.202G>A	p.E68K	Substitution - Missense	Ovary
COSM4609817	c.2216_2217delCT	p.S739fs*1	Deletion - Frameshift	Adrenal_gland
COSM4390114	c.309G>A	p.A103A	Substitution - coding silent	Urinary_tract
COSM5615673	c.34G>C	p.D12H	Substitution - Missense	Lung
COSM3873172	c.767G>A	p.R256H	Substitution - Missense	Large_intestine
COSM85816	c.1403_1403delA	p.E468fs*60	Deletion - Frameshift	Pancreas
COSM1078022	c.955G>A	p.D319N	Substitution - Missense	Endometrium
COSM4963480	c.979C>T	p.R327*	Substitution - Nonsense	Small_intestine
COSM4401850	c.1685C>T	p.P562L	Substitution - Missense	Skin
COSM5019618	c.1137T>C	p.Y379Y	Substitution - coding silent	Soft_tissue
COSM144229	c.1885_1886insC	p.C629fs*29	Insertion - Frameshift	Central_nervous_system
COSM5552226	c.1332T>C	p.D444D	Substitution - coding silent	Prostate
COSM3625706	c.2019G>A	p.L673L	Substitution - coding silent	Skin
COSM5019618	c.1137T>C	p.Y379Y	Substitution - coding silent	Breast
COSM5457257	c.281G>A	p.R94H	Substitution - Missense	Large_intestine
COSM4992715	c.1420C>T	p.Q474*	Substitution - Nonsense	Skin
COSM3625711	c.838C>T	p.P280S	Substitution - Missense	Skin
COSM451304	c.1215T>C	p.S405S	Substitution - coding silent	Breast
COSM1443784	c.1884delC	p.C629fs*16	Deletion - Frameshift	Large_intestine
COSM483939	c.2045C>G	p.S682C	Substitution - Missense	Kidney
COSM3873165	c.1615G>C	p.A539P	Substitution - Missense	Stomach
COSM85803	c.2120_2120delC	p.Q708fs*34	Deletion - Frameshift	Pancreas
COSM5357385	c.1486C>A	p.P496T	Substitution - Missense	Large_intestine
COSM1329756	c.895C>T	p.R299*	Substitution - Nonsense	Ovary
COSM3625709	c.1233C>T	p.A411A	Substitution - coding silent	Skin
COSM4891300	c.1927C>A	p.P643T	Substitution - Missense	Upper_aerodigestive_tract
COSM1249688	c.208-4C>T	p.?	Unknown	Oesophagus
COSM5944150	c.603G>C	p.E201D	Substitution - Missense	Bone
COSM4801878	c.872G>T	p.R291L	Substitution - Missense	Liver
COSM2151099	c.1759T>C	p.S587P	Substitution - Missense	Central_nervous_system
COSM1078019	c.1318G>A	p.D440N	Substitution - Missense	Endometrium
COSM5430448	c.1112G>A	p.R371Q	Substitution - Missense	Oesophagus
COSM1284412	c.1927C>T	p.P643S	Substitution - Missense	Autonomic_ganglia
COSM4169849	c.?	p.H620fs*37	Unknown	Adrenal_gland
COSM5615672	c.809G>A	p.R270H	Substitution - Missense	Lung
COSM335240	c.202G>C	p.E68Q	Substitution - Missense	Lung
COSM79351	c.1601C>A	p.S534*	Substitution - Nonsense	Ovary
COSM373220	c.1214C>G	p.S405C	Substitution - Missense	Lung
COSM5955129	c.274C>T	p.Q92*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM5019541	c.2112C>T	p.A704A	Substitution - coding silent	Soft_tissue
COSM483940	c.1370A>T	p.E457V	Substitution - Missense	Kidney
COSM3411008	c.164G>A	p.G55D	Substitution - Missense	Central_nervous_system
COSM85814	c.102_102delT	p.A36fs*108	Deletion - Frameshift	Pancreas
COSM4139282	c.1411C>T	p.Q471*	Substitution - Nonsense	Pancreas
COSM85812	c.1393G>T	p.E465*	Substitution - Nonsense	Pancreas
COSM742333	c.305C>T	p.S102L	Substitution - Missense	Lung
COSM1203011	c.917G>A	p.R306Q	Substitution - Missense	Large_intestine
COSM596268	c.1500A>G	p.L500L	Substitution - coding silent	Endometrium
COSM85817	c.1342G>T	p.E448*	Substitution - Nonsense	Pancreas
COSM127777	c.1803A>G	p.L601L	Substitution - coding silent	Upper_aerodigestive_tract
COSM1643029	c.1820T>C	p.M607T	Substitution - Missense	Stomach
COSM3349809	c.968G>A	p.R323K	Substitution - Missense	Large_intestine
COSM1078025	c.168G>T	p.K56N	Substitution - Missense	Endometrium
COSM4445260	c.292_293delCT	p.L98fs*13	Deletion - Frameshift	Adrenal_gland
COSM342540	c.529C>T	p.Q177*	Substitution - Nonsense	Lung
COSM122501	c.1609C>A	p.P537T	Substitution - Missense	Upper_aerodigestive_tract
COSM4609818	c.1536_1537insA	p.Q513fs*34	Insertion - Frameshift	Adrenal_gland
COSM138554	c.1763C>T	p.S588F	Substitution - Missense	Skin
COSM3625707	c.1734C>A	p.T578T	Substitution - coding silent	Skin
COSM4139284	c.991G>T	p.D331Y	Substitution - Missense	Pancreas
COSM3349810	c.952C>T	p.R318*	Substitution - Nonsense	Stomach
COSM4801878	c.872G>T	p.R291L	Substitution - Missense	Liver
COSM4445259	c.1176_1180delAAAGA	p.R394fs*22	Deletion - Frameshift	Adrenal_gland
COSM5625324	c.11C>G	p.A4G	Substitution - Missense	Oesophagus

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
27742788	Mutation	Pancreatic Neuroendocrine Tumor	The most frequent alterations found in sporadic PNETs are in MEN1, DAXX/ATRX, and a variety of genes in the mTOR pathway.
27228211	Mutation	Glioma	Pediatric gliomas harbor mutations for H3F3A, ATRX and DAXX but not IDH.
26891131	Mutation	Uterine leiomyosarcoma	Exome data also revealed one nonsense mutation in death-domain associated protein (DAXX), another gene previously associated with ALT, and the tumor showed ALT positivity.
26004297	Mutation	Glioma	Pediatric gliomas differ in their spectrum of disease from those in adults; high grade gliomas occurring in children frequently have mutations in H3F3A, ATRX and DAXX, but not IDH.
25479829	Mutation	Pediatric Glioblastoma multiforme	H3F3A, HIST1H3B, IDH1, ATRX, DAXX and Tp53 mutations were identified by sequencing/immunohistochemistry in 27 pediatric GBMs.
25210493	Mutation	Pancreatic Neuroendocrine Tumor	The somatic mutation frequencies of the DAXX/ATRX, KRAS, MEN1, mTOR pathway genes (PTEN and TSC2), SMAD4/DPC, TP53, and VHL in Chinese pNET patients were 54.05%, 10.81%, 35.14%, 54.05%, 2.70%, 13.51%, and 40.54%, respectively, while the same figures in Caucasians pNET patients were 43%, 0%, 44%, 15%, 0%, 3%, and 0%, respectively.
24747642	Mutation	adrenocortical carcinoma	We performed exome sequencing and SNP array analysis of 45 ACCs and identified recurrent alterations in known driver genes (CTNNB1, TP53, CDKN2A, RB1 and MEN1) and in genes not previously reported in ACC (ZNRF3, DAXX, TERT and MED12), which we validated in an independent cohort of 77 ACCs.
24436263	Mutation; Loss of Expression	Pancreatic Neuroendocrine Tumor	Mutation in DAXX/ATRX is only seen in pancreatic neuroendocrine tumors, making it a useful potential marker in distinguishing these tumors from mimics. Loss of expression of DAXX and ATRX proteins has been recently identified in 45 %.
24375391	Mutation; altered expression	Neuroendocrine Neoplasm	Biological understanding and derived treatment options for NETs have changed markedly in recent years. Over the last decade, the genomic landscape of these tumors has been extensively investigated. This has resulted in the discovery of mutations and expression anomalies in genes and pathways such as the PI3K/Akt/mTOR, DAXX/ATRX, and MEN1, which are promising predictive and prognostic biomarkers and future candidates for targeted therapies.
23429748	Mutation	Pancreatic Neuroendocrine Tumor	Recent progress has been facilitated by development of high-throughput tools including second-generation sequencing and arrays for analysis of the 'epigenome' of tumour and normal tissue, permitting unbiased approaches such as exome sequencing that identified mutations of chromatin-remodelling genes ATRX/DAXX in 44% of pancreatic NETs.
22310917	Mutation	Pancreatic Neuroendocrine Tumor	In particular, we discuss two genes (DAXX and ATRX) that have collectively been identified as mutated in >40% of PanNETs, and the biological and prognostic implications of these novel mutations.
21719641	Mutation; Loss of Expression	Pancreatic Neuroendocrine Tumor	All of the PanNETs exhibiting these abnormal telomeres had ATRX or DAXX mutations or loss of nuclear ATRX or DAXX protein.
21252315	Mutation	Pancreatic Neuroendocrine Tumor	The most frequently mutated genes specify proteins implicated in chromatin remodeling: 44% of the tumors had somatic inactivating mutations in MEN1, which encodes menin, a component of a histone methyltransferase complex, and 43% had mutations in genes encoding either of the two subunits of a transcription/chromatin remodeling complex consisting of DAXX (death-domain-associated protein) and ATRX (α thalassemia/mental retardation syndrome X-linked).

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UER7	178	S	Phosphoserine	-	No	None detected
Q9UER7	213	S	Phosphoserine	-	No	None detected
Q9UER7	412	S	Phosphoserine	-	No	None detected
Q9UER7	424	S	Phosphoserine	-	No	None detected
Q9UER7	459	T	Phosphothreonine	-	No	None detected
Q9UER7	495	S	Phosphoserine	-	No	None detected
Q9UER7	498	S	Phosphoserine	-	No	None detected
Q9UER7	512	K	N6-acetyllysine	-	No	None detected
Q9UER7	561	S	Phosphoserine	-	No	None detected
Q9UER7	580	S	Phosphoserine	-	No	None detected
Q9UER7	668	S	Phosphoserine	-	No	None detected
Q9UER7	671	S	Phosphoserine	-	Yes	p.S671F (cancer: HNSC)
Q9UER7	688	S	Phosphoserine	-	No	None detected
Q9UER7	702	S	Phosphoserine	-	Yes	p.S702F (cancer: CESC)
Q9UER7	737	S	Phosphoserine	-	No	None detected
Q9UER7	739	S	Phosphoserine	-	No	None detected

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.122	6.391	0.345	0.000729	NS
BRCA	Breast invasive carcinoma	112	1100	5.969	6.58	0.648	7.52e-43	Over
CESC	Cervical and endocervical cancers	3	306	6.172	6.503	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.052	6.241	0.168	0.00418	NS
ESCA	Esophageal carcinoma	11	185	5.29	5.99	0.568	0.000125	NS
GBM	Glioblastoma multiforme	5	166	5.536	6.248	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.957	6.245	0.335	7.32e-08	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.392	5.905	0.476	3.53e-26	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.474	5.713	0.256	0.000169	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.162	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.988	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.958	5.556	0.638	5.98e-16	Over
LUAD	Lung adenocarcinoma	59	517	5.769	6.047	0.263	9.9e-07	NS
LUSC	Lung squamous cell carcinoma	51	501	5.847	6.257	0.411	1.59e-11	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.141	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.279	5.982	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.35	5.719	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.833	5.892	0.05	0.167	NS
READ	Rectum adenocarcinoma	10	167	5.916	6.243	0.346	0.00425	NS
SARC	Sarcoma	2	263	5.847	6.349	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.874	6.529	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.784	5.951	0.175	0.0382	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.701	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.914	5.908	-0.008	0.829	NS
THYM	Thymoma	2	120	6.613	6.731	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.116	6.279	0.136	0.0931	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.1
Autonomic ganglia	CHP212	8
Autonomic ganglia	IMR32	9.3
Autonomic ganglia	KELLY	8.5
Autonomic ganglia	KPNRTBM1	8.5
Autonomic ganglia	KPNSI9S	8.1
Autonomic ganglia	KPNYN	8.7
Autonomic ganglia	MHHNB11	8.1
Autonomic ganglia	NB1	8.4
Autonomic ganglia	NH6	8.4
Autonomic ganglia	SHSY5Y	8.7
Autonomic ganglia	SIMA	9.1
Autonomic ganglia	SKNAS	8.7
Autonomic ganglia	SKNBE2	8.4
Autonomic ganglia	SKNDZ	9
Autonomic ganglia	SKNFI	9.3
Autonomic ganglia	SKNSH	8.5
Biliary tract	HUCCT1	7.6
Biliary tract	HUH28	7.7
Biliary tract	SNU1079	7.8
Biliary tract	SNU1196	8
Biliary tract	SNU245	8.3
Biliary tract	SNU308	7.6
Biliary tract	SNU478	8.5
Bone	143B	8.6
Bone	A673	8.5
Bone	CADOES1	8.3
Bone	CAL78	8.2
Bone	G292CLONEA141B1	5.1
Bone	HOS	8.5
Bone	HS706T	7.7
Bone	HS737T	7.5
Bone	HS819T	7.2
Bone	HS821T	7.4
Bone	HS822T	7.2
Bone	HS863T	7.8
Bone	HS870T	7.8
Bone	HS888T	7.6
Bone	MG63	7.8
Bone	MHHES1	8
Bone	OUMS27	7.8
Bone	RDES	8.7
Bone	SJSA1	7.8
Bone	SKES1	8.7
Bone	SKNMC	8.7
Bone	SW1353	7.6
Bone	T173	7.9
Bone	TC71	8.4
Bone	U2OS	8.4
Breast	AU565	8.7
Breast	BT20	8.7
Breast	BT474	8.1
Breast	BT483	8.2
Breast	BT549	9.4
Breast	CAL120	8.5
Breast	CAL148	9
Breast	CAL51	8.2
Breast	CAL851	8.6
Breast	CAMA1	8.9
Breast	DU4475	8.3
Breast	EFM192A	8.2
Breast	EFM19	8.2
Breast	EVSAT	9
Breast	HCC1143	8.7
Breast	HCC1187	8.8
Breast	HCC1395	8.7
Breast	HCC1419	7.8
Breast	HCC1428	7.8
Breast	HCC1500	8.6
Breast	HCC1569	8.1
Breast	HCC1599	8.2
Breast	HCC1806	8.6
Breast	HCC1937	8
Breast	HCC1954	8.4
Breast	HCC202	8.6
Breast	HCC2157	7.7
Breast	HCC2218	7.6
Breast	HCC38	8.3
Breast	HCC70	8.3
Breast	HDQP1	8.4
Breast	HMC18	8.1
Breast	HS274T	7.6
Breast	HS281T	7.6
Breast	HS343T	8.1
Breast	HS578T	8.6
Breast	HS606T	8.1
Breast	HS739T	8
Breast	HS742T	7.6
Breast	JIMT1	8.5
Breast	KPL1	7.8
Breast	MCF7	7.8
Breast	MDAMB134VI	8.5
Breast	MDAMB157	7.6
Breast	MDAMB175VII	7.2
Breast	MDAMB231	8.3
Breast	MDAMB361	7.7
Breast	MDAMB415	8.2
Breast	MDAMB436	8.1
Breast	MDAMB453	8.2
Breast	MDAMB468	9
Breast	SKBR3	8.4
Breast	T47D	8.2
Breast	UACC812	7.5
Breast	UACC893	8.3
Breast	YMB1	7.9
Breast	ZR751	7.5
Breast	ZR7530	7.5
Central nervous system	1321N1	8.7
Central nervous system	42MGBA	8.6
Central nervous system	8MGBA	8.5
Central nervous system	A172	7.9
Central nervous system	AM38	8.1
Central nervous system	BECKER	8.4
Central nervous system	CAS1	8.4
Central nervous system	CCFSTTG1	7.8
Central nervous system	D283MED	8.8
Central nervous system	D341MED	7.8
Central nervous system	DAOY	8.8
Central nervous system	DBTRG05MG	7.2
Central nervous system	DKMG	6.6
Central nervous system	GAMG	8.6
Central nervous system	GB1	8.4
Central nervous system	GI1	8.4
Central nervous system	GMS10	8.5
Central nervous system	GOS3	7.6
Central nervous system	H4	8
Central nervous system	HS683	7.6
Central nervous system	KALS1	8.3
Central nervous system	KG1C	8.2
Central nervous system	KNS42	8
Central nervous system	KNS60	8.4
Central nervous system	KNS81	7.4
Central nervous system	KS1	8.1
Central nervous system	LN18	9
Central nervous system	LN229	7.7
Central nervous system	M059K	9
Central nervous system	MOGGCCM	8.6
Central nervous system	MOGGUVW	8.9
Central nervous system	NMCG1	7.8
Central nervous system	ONS76	7.6
Central nervous system	SF126	8.1
Central nervous system	SF295	8.2
Central nervous system	SNB19	7.7
Central nervous system	SNU1105	8.1
Central nervous system	SNU201	7.8
Central nervous system	SNU466	7.8
Central nervous system	SNU489	8.7
Central nervous system	SNU626	8.2
Central nervous system	SNU738	8
Central nervous system	SW1088	7.8
Central nervous system	SW1783	8.1
Central nervous system	T98G	8.3
Central nervous system	TM31	7.7
Central nervous system	U118MG	9
Central nervous system	U138MG	7.9
Central nervous system	U251MG	7.2
Central nervous system	U87MG	8
Central nervous system	YH13	7.9
Central nervous system	YKG1	7.5
Endometrium	AN3CA	9.3
Endometrium	COLO684	9
Endometrium	EFE184	7.9
Endometrium	EN	8.3
Endometrium	ESS1	8.9
Endometrium	HEC108	7.7
Endometrium	HEC151	8.1
Endometrium	HEC1A	8.2
Endometrium	HEC1B	8.4
Endometrium	HEC251	7.3
Endometrium	HEC265	7.7
Endometrium	HEC50B	7.9
Endometrium	HEC59	7.6
Endometrium	HEC6	7.8
Endometrium	ISHIKAWAHERAKLIO02ER	7.3
Endometrium	JHUEM1	7.7
Endometrium	JHUEM2	8.2
Endometrium	JHUEM3	7.4
Endometrium	KLE	7.9
Endometrium	MFE280	8.1
Endometrium	MFE296	8.7
Endometrium	MFE319	7.8
Endometrium	RL952	8.3
Endometrium	SNGM	7.9
Endometrium	SNU1077	7.4
Endometrium	SNU685	8.3
Endometrium	TEN	7.7
Haematopoietic and lymphoid	697	8.5
Haematopoietic and lymphoid	A3KAW	8.1
Haematopoietic and lymphoid	A4FUK	8.3
Haematopoietic and lymphoid	ALLSIL	9.2
Haematopoietic and lymphoid	AML193	8.8
Haematopoietic and lymphoid	AMO1	7.9
Haematopoietic and lymphoid	BCP1	8.6
Haematopoietic and lymphoid	BDCM	8.3
Haematopoietic and lymphoid	BL41	9.3
Haematopoietic and lymphoid	BL70	9.1
Haematopoietic and lymphoid	BV173	8
Haematopoietic and lymphoid	CA46	7.9
Haematopoietic and lymphoid	CI1	8.8
Haematopoietic and lymphoid	CMK115	8.5
Haematopoietic and lymphoid	CMK86	9
Haematopoietic and lymphoid	CMK	8.3
Haematopoietic and lymphoid	CMLT1	8.4
Haematopoietic and lymphoid	COLO775	8.8
Haematopoietic and lymphoid	DAUDI	8.8
Haematopoietic and lymphoid	DB	9
Haematopoietic and lymphoid	DEL	8.2
Haematopoietic and lymphoid	DND41	9
Haematopoietic and lymphoid	DOHH2	9.7
Haematopoietic and lymphoid	EB1	7.8
Haematopoietic and lymphoid	EB2	7.5
Haematopoietic and lymphoid	EHEB	8.1
Haematopoietic and lymphoid	EJM	8.6
Haematopoietic and lymphoid	EM2	9.5
Haematopoietic and lymphoid	EOL1	8.5
Haematopoietic and lymphoid	F36P	8
Haematopoietic and lymphoid	GA10	9.3
Haematopoietic and lymphoid	GDM1	8.5
Haematopoietic and lymphoid	GRANTA519	8.5
Haematopoietic and lymphoid	HDLM2	7.9
Haematopoietic and lymphoid	HDMYZ	8.2
Haematopoietic and lymphoid	HEL9217	8.9
Haematopoietic and lymphoid	HEL	8.6
Haematopoietic and lymphoid	HH	8.7
Haematopoietic and lymphoid	HL60	8.8
Haematopoietic and lymphoid	HPBALL	9.1
Haematopoietic and lymphoid	HS604T	7.6
Haematopoietic and lymphoid	HS611T	8.5
Haematopoietic and lymphoid	HS616T	7.9
Haematopoietic and lymphoid	HS751T	7
Haematopoietic and lymphoid	HT	9.2
Haematopoietic and lymphoid	HTK	8.6
Haematopoietic and lymphoid	HUNS1	8.6
Haematopoietic and lymphoid	HUT102	8
Haematopoietic and lymphoid	HUT78	8.4
Haematopoietic and lymphoid	JEKO1	9.2
Haematopoietic and lymphoid	JK1	7.9
Haematopoietic and lymphoid	JM1	9.2
Haematopoietic and lymphoid	JURKAT	8.7
Haematopoietic and lymphoid	JURLMK1	8.6
Haematopoietic and lymphoid	JVM2	7.8
Haematopoietic and lymphoid	JVM3	7.8
Haematopoietic and lymphoid	K562	8.2
Haematopoietic and lymphoid	KARPAS299	7.5
Haematopoietic and lymphoid	KARPAS422	8.6
Haematopoietic and lymphoid	KARPAS620	8.4
Haematopoietic and lymphoid	KASUMI1	7.4
Haematopoietic and lymphoid	KASUMI2	8.5
Haematopoietic and lymphoid	KASUMI6	8.5
Haematopoietic and lymphoid	KCL22	8.6
Haematopoietic and lymphoid	KE37	8.3
Haematopoietic and lymphoid	KE97	8
Haematopoietic and lymphoid	KG1	8.2
Haematopoietic and lymphoid	KHM1B	8.8
Haematopoietic and lymphoid	KIJK	8.4
Haematopoietic and lymphoid	KMH2	8.5
Haematopoietic and lymphoid	KMM1	9.4
Haematopoietic and lymphoid	KMS11	8
Haematopoietic and lymphoid	KMS12BM	9.4
Haematopoietic and lymphoid	KMS18	7.9
Haematopoietic and lymphoid	KMS20	8.2
Haematopoietic and lymphoid	KMS21BM	7.7
Haematopoietic and lymphoid	KMS26	7.7
Haematopoietic and lymphoid	KMS27	8.5
Haematopoietic and lymphoid	KMS28BM	8.2
Haematopoietic and lymphoid	KMS34	8.1
Haematopoietic and lymphoid	KO52	8
Haematopoietic and lymphoid	KOPN8	9
Haematopoietic and lymphoid	KU812	8.9
Haematopoietic and lymphoid	KYO1	9.4
Haematopoietic and lymphoid	L1236	9.3
Haematopoietic and lymphoid	L363	7.4
Haematopoietic and lymphoid	L428	8.5
Haematopoietic and lymphoid	L540	8.1
Haematopoietic and lymphoid	LAMA84	8.6
Haematopoietic and lymphoid	LOUCY	8.3
Haematopoietic and lymphoid	LP1	8
Haematopoietic and lymphoid	M07E	8.4
Haematopoietic and lymphoid	MC116	8.7
Haematopoietic and lymphoid	ME1	9.1
Haematopoietic and lymphoid	MEC1	8.2
Haematopoietic and lymphoid	MEC2	8.1
Haematopoietic and lymphoid	MEG01	8.9
Haematopoietic and lymphoid	MHHCALL2	8.1
Haematopoietic and lymphoid	MHHCALL3	8.5
Haematopoietic and lymphoid	MHHCALL4	8.6
Haematopoietic and lymphoid	MINO	8.7
Haematopoietic and lymphoid	MJ	8.5
Haematopoietic and lymphoid	MM1S	8.7
Haematopoietic and lymphoid	MOLM13	8.7
Haematopoietic and lymphoid	MOLM16	8.8
Haematopoietic and lymphoid	MOLM6	8.5
Haematopoietic and lymphoid	MOLP2	10.3
Haematopoietic and lymphoid	MOLP8	7.1
Haematopoietic and lymphoid	MOLT13	8.4
Haematopoietic and lymphoid	MOLT16	8.5
Haematopoietic and lymphoid	MOLT4	9.1
Haematopoietic and lymphoid	MONOMAC1	7.9
Haematopoietic and lymphoid	MONOMAC6	8.6
Haematopoietic and lymphoid	MOTN1	8.7
Haematopoietic and lymphoid	MUTZ5	8.6
Haematopoietic and lymphoid	MV411	8.7
Haematopoietic and lymphoid	NALM19	9
Haematopoietic and lymphoid	NALM1	8.3
Haematopoietic and lymphoid	NALM6	8.7
Haematopoietic and lymphoid	NAMALWA	9.1
Haematopoietic and lymphoid	NB4	9
Haematopoietic and lymphoid	NCIH929	8
Haematopoietic and lymphoid	NCO2	9.1
Haematopoietic and lymphoid	NOMO1	7.9
Haematopoietic and lymphoid	NUDHL1	8.9
Haematopoietic and lymphoid	NUDUL1	8
Haematopoietic and lymphoid	OCIAML2	7.8
Haematopoietic and lymphoid	OCIAML3	8.3
Haematopoietic and lymphoid	OCIAML5	7.9
Haematopoietic and lymphoid	OCILY10	8.9
Haematopoietic and lymphoid	OCILY19	9.5
Haematopoietic and lymphoid	OCILY3	8.1
Haematopoietic and lymphoid	OCIM1	8.1
Haematopoietic and lymphoid	OPM2	7.3
Haematopoietic and lymphoid	P12ICHIKAWA	8.8
Haematopoietic and lymphoid	P31FUJ	8.3
Haematopoietic and lymphoid	P3HR1	9.1
Haematopoietic and lymphoid	PCM6	8.6
Haematopoietic and lymphoid	PEER	8.7
Haematopoietic and lymphoid	PF382	8.7
Haematopoietic and lymphoid	PFEIFFER	8.5
Haematopoietic and lymphoid	PL21	8.4
Haematopoietic and lymphoid	RAJI	8.5
Haematopoietic and lymphoid	RCHACV	8.4
Haematopoietic and lymphoid	REC1	8.4
Haematopoietic and lymphoid	REH	8.7
Haematopoietic and lymphoid	RI1	10.4
Haematopoietic and lymphoid	RL	9.2
Haematopoietic and lymphoid	RPMI8226	8.3
Haematopoietic and lymphoid	RPMI8402	8.6
Haematopoietic and lymphoid	RS411	8.6
Haematopoietic and lymphoid	SEM	8.3
Haematopoietic and lymphoid	SET2	8.5
Haematopoietic and lymphoid	SIGM5	8.3
Haematopoietic and lymphoid	SKM1	8.4
Haematopoietic and lymphoid	SKMM2	8
Haematopoietic and lymphoid	SR786	7.9
Haematopoietic and lymphoid	ST486	8.8
Haematopoietic and lymphoid	SUDHL10	9.2
Haematopoietic and lymphoid	SUDHL1	7.7
Haematopoietic and lymphoid	SUDHL4	9.2
Haematopoietic and lymphoid	SUDHL5	9.1
Haematopoietic and lymphoid	SUDHL6	10.3
Haematopoietic and lymphoid	SUDHL8	7.8
Haematopoietic and lymphoid	SUPB15	8.5
Haematopoietic and lymphoid	SUPHD1	6.9
Haematopoietic and lymphoid	SUPM2	7.8
Haematopoietic and lymphoid	SUPT11	9.5
Haematopoietic and lymphoid	SUPT1	8.7
Haematopoietic and lymphoid	TALL1	8.4
Haematopoietic and lymphoid	TF1	9.1
Haematopoietic and lymphoid	THP1	8.5
Haematopoietic and lymphoid	TO175T	7.8
Haematopoietic and lymphoid	TOLEDO	8.1
Haematopoietic and lymphoid	U266B1	8.5
Haematopoietic and lymphoid	U937	8.2
Haematopoietic and lymphoid	UT7	8.3
Haematopoietic and lymphoid	WSUDLCL2	8.4
Kidney	769P	8.3
Kidney	786O	8
Kidney	A498	8.1
Kidney	A704	7.1
Kidney	ACHN	7.4
Kidney	BFTC909	7.8
Kidney	CAKI1	7.5
Kidney	CAKI2	8.6
Kidney	CAL54	7.7
Kidney	KMRC1	8
Kidney	KMRC20	7.8
Kidney	KMRC2	8.2
Kidney	KMRC3	8.2
Kidney	OSRC2	7.6
Kidney	RCC10RGB	7.8
Kidney	SNU1272	7.8
Kidney	SNU349	8.8
Kidney	TUHR10TKB	8
Kidney	TUHR14TKB	7.1
Kidney	TUHR4TKB	7.9
Kidney	VMRCRCW	8
Kidney	VMRCRCZ	7.9
Large intestine	C2BBE1	8.2
Large intestine	CCK81	8.6
Large intestine	CL11	7.5
Large intestine	CL14	8.4
Large intestine	CL34	7.9
Large intestine	CL40	7.9
Large intestine	COLO205	7.3
Large intestine	COLO320	8.3
Large intestine	COLO678	8.1
Large intestine	CW2	8.6
Large intestine	DLD1	8.1
Large intestine	GP2D	7.6
Large intestine	HCC56	8.2
Large intestine	HCT116	8.7
Large intestine	HCT15	8.1
Large intestine	HS675T	7.7
Large intestine	HS698T	7.8
Large intestine	HT115	8.1
Large intestine	HT29	8.5
Large intestine	HT55	6.3
Large intestine	KM12	6.9
Large intestine	LOVO	8.1
Large intestine	LS1034	7.5
Large intestine	LS123	8
Large intestine	LS180	8.5
Large intestine	LS411N	8.1
Large intestine	LS513	7.2
Large intestine	MDST8	8.2
Large intestine	NCIH508	8.2
Large intestine	NCIH716	7.8
Large intestine	NCIH747	7.8
Large intestine	OUMS23	7.8
Large intestine	RCM1	7.8
Large intestine	RKO	8.4
Large intestine	SKCO1	6.9
Large intestine	SNU1040	7.8
Large intestine	SNU1197	8.2
Large intestine	SNU175	8.1
Large intestine	SNU283	7.6
Large intestine	SNU407	8.1
Large intestine	SNU503	7.6
Large intestine	SNU61	7.7
Large intestine	SNU81	7.9
Large intestine	SNUC1	7.7
Large intestine	SNUC2A	8.5
Large intestine	SNUC4	8.4
Large intestine	SNUC5	7.6
Large intestine	SW1116	7.2
Large intestine	SW1417	8.1
Large intestine	SW1463	8
Large intestine	SW403	8.1
Large intestine	SW480	7.4
Large intestine	SW48	7.5
Large intestine	SW620	8.5
Large intestine	SW837	6.4
Large intestine	SW948	7.9
Large intestine	T84	8.1
Liver	ALEXANDERCELLS	7.8
Liver	C3A	8.1
Liver	HEP3B217	8.2
Liver	HEPG2	8.3
Liver	HLE	8
Liver	HLF	8.9
Liver	HUH1	8.1
Liver	HUH6	7.7
Liver	HUH7	7.7
Liver	JHH1	7.7
Liver	JHH2	9.4
Liver	JHH4	8.1
Liver	JHH5	7.9
Liver	JHH6	7.1
Liver	JHH7	8.2
Liver	LI7	7.8
Liver	PLCPRF5	8.4
Liver	SKHEP1	7.9
Liver	SNU182	7.4
Liver	SNU387	8.6
Liver	SNU398	8.9
Liver	SNU423	8.9
Liver	SNU449	8.5
Liver	SNU475	8.5
Liver	SNU761	7.8
Liver	SNU878	6.8
Liver	SNU886	8.5
Lung	A549	7.5
Lung	ABC1	8
Lung	BEN	7.6
Lung	CAL12T	7.8
Lung	CALU1	8
Lung	CALU3	8.6
Lung	CALU6	7.8
Lung	CHAGOK1	7
Lung	COLO668	7.6
Lung	COLO699	8.2
Lung	CORL105	8.2
Lung	CORL23	8.2
Lung	CORL24	7.4
Lung	CORL279	8.2
Lung	CORL311	8.1
Lung	CORL47	7.9
Lung	CORL51	8
Lung	CORL88	8.6
Lung	CORL95	7.4
Lung	CPCN	9.1
Lung	DMS114	8.6
Lung	DMS153	8.2
Lung	DMS273	8.2
Lung	DMS454	7.3
Lung	DMS53	7.9
Lung	DMS79	8.1
Lung	DV90	8.3
Lung	EBC1	8.2
Lung	EPLC272H	8.4
Lung	HARA	8
Lung	HCC1171	7.8
Lung	HCC1195	7.5
Lung	HCC15	7.9
Lung	HCC2279	7.9
Lung	HCC2935	8.4
Lung	HCC33	8.9
Lung	HCC366	8.1
Lung	HCC4006	8.5
Lung	HCC44	8.1
Lung	HCC78	7.5
Lung	HCC827	7.6
Lung	HCC95	7.9
Lung	HLC1	8.1
Lung	HLFA	7.8
Lung	HS229T	8.3
Lung	HS618T	8
Lung	IALM	8
Lung	KNS62	7.7
Lung	LC1F	7.9
Lung	LC1SQSF	7.3
Lung	LCLC103H	9.2
Lung	LCLC97TM1	7.5
Lung	LK2	8.3
Lung	LOUNH91	8.3
Lung	LU65	8
Lung	LU99	8.2
Lung	LUDLU1	8.1
Lung	LXF289	7.9
Lung	MORCPR	8.3
Lung	NCIH1048	8
Lung	NCIH1092	6.8
Lung	NCIH1105	8.2
Lung	NCIH1155	8.8
Lung	NCIH1184	8.7
Lung	NCIH1299	9
Lung	NCIH1339	8.1
Lung	NCIH1341	8.1
Lung	NCIH1355	7.8
Lung	NCIH1373	8.2
Lung	NCIH1385	7.4
Lung	NCIH1395	7.8
Lung	NCIH1435	7.7
Lung	NCIH1436	7.6
Lung	NCIH1437	7.5
Lung	NCIH146	8.7
Lung	NCIH1563	7.8
Lung	NCIH1568	7.6
Lung	NCIH1573	6.9
Lung	NCIH1581	8.5
Lung	NCIH1618	8
Lung	NCIH1623	7.5
Lung	NCIH1648	7.5
Lung	NCIH1650	7.4
Lung	NCIH1651	7.5
Lung	NCIH1666	8.4
Lung	NCIH1693	7.9
Lung	NCIH1694	8.1
Lung	NCIH1703	8.9
Lung	NCIH1734	8.7
Lung	NCIH1755	8.7
Lung	NCIH1781	8.2
Lung	NCIH1792	7.7
Lung	NCIH1793	7.7
Lung	NCIH1836	8.8
Lung	NCIH1838	7.8
Lung	NCIH1869	8.4
Lung	NCIH1876	7.6
Lung	NCIH1915	8
Lung	NCIH1930	8.3
Lung	NCIH1944	7.6
Lung	NCIH1963	8.6
Lung	NCIH196	8.6
Lung	NCIH1975	7.5
Lung	NCIH2009	7.9
Lung	NCIH2023	7.9
Lung	NCIH2029	8.4
Lung	NCIH2030	9
Lung	NCIH2066	8.6
Lung	NCIH2081	7.4
Lung	NCIH2085	8.2
Lung	NCIH2087	7.1
Lung	NCIH209	9.2
Lung	NCIH2106	8.9
Lung	NCIH2110	6.6
Lung	NCIH211	8.4
Lung	NCIH2122	7.7
Lung	NCIH2126	7.7
Lung	NCIH2141	8.3
Lung	NCIH2170	8
Lung	NCIH2171	8.9
Lung	NCIH2172	7.5
Lung	NCIH2196	8.6
Lung	NCIH2227	9
Lung	NCIH2228	7.5
Lung	NCIH226	8.3
Lung	NCIH2286	7.1
Lung	NCIH2291	7
Lung	NCIH2342	7.7
Lung	NCIH2347	7.3
Lung	NCIH23	9.1
Lung	NCIH2405	8.2
Lung	NCIH2444	8.1
Lung	NCIH292	8
Lung	NCIH322	7.9
Lung	NCIH3255	8.3
Lung	NCIH358	8.1
Lung	NCIH441	7.6
Lung	NCIH446	8.7
Lung	NCIH460	7.8
Lung	NCIH510	8.7
Lung	NCIH520	8.5
Lung	NCIH522	8.4
Lung	NCIH524	8.9
Lung	NCIH526	9.1
Lung	NCIH596	7.3
Lung	NCIH647	7.9
Lung	NCIH650	8.4
Lung	NCIH661	7.8
Lung	NCIH69	8.9
Lung	NCIH727	7.1
Lung	NCIH810	8.1
Lung	NCIH82	8.8
Lung	NCIH838	8.1
Lung	NCIH841	8.3
Lung	NCIH854	7.8
Lung	NCIH889	8.4
Lung	PC14	8.1
Lung	RERFLCAD1	8.2
Lung	RERFLCAD2	7.5
Lung	RERFLCAI	8.6
Lung	RERFLCKJ	7.9
Lung	RERFLCMS	7.7
Lung	RERFLCSQ1	8.6
Lung	SBC5	7.9
Lung	SCLC21H	8.8
Lung	SHP77	8.9
Lung	SKLU1	8.7
Lung	SKMES1	7.5
Lung	SQ1	8.6
Lung	SW1271	9.1
Lung	SW1573	7.3
Lung	SW900	7.5
Lung	VMRCLCD	9
Lung	VMRCLCP	8.1
Oesophagus	COLO680N	7.4
Oesophagus	ECGI10	7.9
Oesophagus	KYSE140	8.4
Oesophagus	KYSE150	8.5
Oesophagus	KYSE180	8.6
Oesophagus	KYSE270	8.4
Oesophagus	KYSE30	8.1
Oesophagus	KYSE410	8.1
Oesophagus	KYSE450	8.2
Oesophagus	KYSE510	8.2
Oesophagus	KYSE520	7.5
Oesophagus	KYSE70	7.1
Oesophagus	OE19	8
Oesophagus	OE33	7.5
Oesophagus	TE10	8.4
Oesophagus	TE11	8.3
Oesophagus	TE14	7.4
Oesophagus	TE15	8
Oesophagus	TE1	8.3
Oesophagus	TE4	7.8
Oesophagus	TE5	8.2
Oesophagus	TE6	8
Oesophagus	TE8	7.6
Oesophagus	TE9	8
Oesophagus	TT	8.1
Ovary	59M	8.9
Ovary	A2780	8.8
Ovary	CAOV3	8.4
Ovary	CAOV4	7.6
Ovary	COLO704	8.6
Ovary	COV318	7.9
Ovary	COV362	7.3
Ovary	COV434	7.4
Ovary	COV504	7.6
Ovary	COV644	7.1
Ovary	EFO21	7.3
Ovary	EFO27	8.3
Ovary	ES2	8.5
Ovary	FUOV1	8.6
Ovary	HEYA8	8
Ovary	HS571T	7.7
Ovary	IGROV1	8.3
Ovary	JHOC5	8.3
Ovary	JHOM1	8.3
Ovary	JHOM2B	7.8
Ovary	JHOS2	7.3
Ovary	JHOS4	8.1
Ovary	KURAMOCHI	8.3
Ovary	MCAS	8.7
Ovary	NIHOVCAR3	8.1
Ovary	OAW28	7.1
Ovary	OAW42	7.9
Ovary	OC314	8
Ovary	OC316	8.2
Ovary	ONCODG1	7.6
Ovary	OV56	7.3
Ovary	OV7	8
Ovary	OV90	7.8
Ovary	OVCAR4	8
Ovary	OVCAR8	7.9
Ovary	OVISE	7.1
Ovary	OVK18	8.8
Ovary	OVKATE	6.5
Ovary	OVMANA	6.1
Ovary	OVSAHO	8.5
Ovary	OVTOKO	7.7
Ovary	RMGI	8
Ovary	RMUGS	8.1
Ovary	SKOV3	7.6
Ovary	SNU119	8.3
Ovary	SNU840	8.1
Ovary	SNU8	8.3
Ovary	TOV112D	9.1
Ovary	TOV21G	8.3
Ovary	TYKNU	8.5
Pancreas	ASPC1	7.8
Pancreas	BXPC3	8
Pancreas	CAPAN1	8
Pancreas	CAPAN2	7.2
Pancreas	CFPAC1	7.7
Pancreas	DANG	8.7
Pancreas	HPAC	7.4
Pancreas	HPAFII	7.5
Pancreas	HS766T	7.9
Pancreas	HUPT3	7.1
Pancreas	HUPT4	8.2
Pancreas	KCIMOH1	7.3
Pancreas	KLM1	8.6
Pancreas	KP2	8
Pancreas	KP3	6.9
Pancreas	KP4	8.5
Pancreas	L33	7.9
Pancreas	MIAPACA2	9
Pancreas	PANC0203	7.3
Pancreas	PANC0213	8.1
Pancreas	PANC0327	8.4
Pancreas	PANC0403	7
Pancreas	PANC0504	7.4
Pancreas	PANC0813	8.5
Pancreas	PANC1005	8.1
Pancreas	PANC1	8.4
Pancreas	PATU8902	8.6
Pancreas	PATU8988S	7.4
Pancreas	PATU8988T	8.8
Pancreas	PK1	7.7
Pancreas	PK45H	7.9
Pancreas	PK59	7.7
Pancreas	PL45	7.9
Pancreas	PSN1	7.7
Pancreas	QGP1	8.1
Pancreas	SNU213	7.8
Pancreas	SNU324	8.3
Pancreas	SNU410	8
Pancreas	SU8686	7.3
Pancreas	SUIT2	7.1
Pancreas	SW1990	8.2
Pancreas	T3M4	7.9
Pancreas	TCCPAN2	8.5
Pancreas	YAPC	7.1
Pleura	ACCMESO1	8.3
Pleura	DM3	8.7
Pleura	ISTMES1	8.4
Pleura	ISTMES2	8.3
Pleura	JL1	8.3
Pleura	MPP89	8.4
Pleura	MSTO211H	8
Pleura	NCIH2052	7.7
Pleura	NCIH2452	8.5
Pleura	NCIH28	8.2
Prostate	22RV1	8.4
Prostate	DU145	8.3
Prostate	LNCAPCLONEFGC	7.9
Prostate	MDAPCA2B	7.9
Prostate	NCIH660	8.1
Prostate	PC3	7.9
Prostate	VCAP	8.3
Salivary gland	A253	7.3
Salivary gland	YD15	8.3
Skin	A101D	8.5
Skin	A2058	9.5
Skin	A375	8.6
Skin	C32	7.5
Skin	CHL1	8.2
Skin	CJM	7.1
Skin	COLO679	7.6
Skin	COLO741	8.3
Skin	COLO783	6.8
Skin	COLO792	8.4
Skin	COLO800	8.4
Skin	COLO818	7.3
Skin	COLO829	7.7
Skin	COLO849	8.5
Skin	G361	8.1
Skin	GRM	8.8
Skin	HMCB	8.6
Skin	HS294T	8.6
Skin	HS600T	7.5
Skin	HS688AT	7.5
Skin	HS695T	7.9
Skin	HS839T	7.9
Skin	HS852T	7.8
Skin	HS895T	8.1
Skin	HS934T	7.8
Skin	HS936T	7.9
Skin	HS939T	8.2
Skin	HS940T	7.8
Skin	HS944T	9.4
Skin	HT144	8.6
Skin	IGR1	7.1
Skin	IGR37	8.6
Skin	IGR39	7.7
Skin	IPC298	8.4
Skin	K029AX	7.7
Skin	LOXIMVI	9.7
Skin	MALME3M	7.8
Skin	MDAMB435S	7.9
Skin	MELHO	8.3
Skin	MELJUSO	8.3
Skin	MEWO	7.7
Skin	RPMI7951	7.8
Skin	RVH421	8
Skin	SH4	7.9
Skin	SKMEL1	8.1
Skin	SKMEL24	7.4
Skin	SKMEL28	7.6
Skin	SKMEL2	8.5
Skin	SKMEL30	8.4
Skin	SKMEL31	7.3
Skin	SKMEL3	7.8
Skin	SKMEL5	8
Skin	UACC257	8.5
Skin	UACC62	7.4
Skin	WM115	7.7
Skin	WM1799	7.2
Skin	WM2664	7.7
Skin	WM793	8.2
Skin	WM88	8.2
Skin	WM983B	7.4
Small intestine	HUTU80	8.4
Soft tissue	A204	8.4
Soft tissue	G401	8.3
Soft tissue	G402	8.1
Soft tissue	GCT	9
Soft tissue	HS729	8.4
Soft tissue	HT1080	8.6
Soft tissue	KYM1	7.8
Soft tissue	MESSA	8.6
Soft tissue	RD	7.9
Soft tissue	RH30	9
Soft tissue	RH41	8.1
Soft tissue	RKN	8.5
Soft tissue	S117	8.2
Soft tissue	SJRH30	8.3
Soft tissue	SKLMS1	8.5
Soft tissue	SKUT1	8.6
Soft tissue	TE125T	7.7
Soft tissue	TE159T	7.6
Soft tissue	TE441T	8.4
Soft tissue	TE617T	8.2
Stomach	2313287	7.9
Stomach	AGS	7.8
Stomach	AZ521	8.4
Stomach	ECC10	8.6
Stomach	ECC12	8.4
Stomach	FU97	7.8
Stomach	GCIY	8.1
Stomach	GSS	8.4
Stomach	GSU	8
Stomach	HGC27	8.3
Stomach	HS746T	8
Stomach	HUG1N	9.2
Stomach	IM95	8
Stomach	KATOIII	8
Stomach	KE39	7.6
Stomach	LMSU	8.3
Stomach	MKN1	7.5
Stomach	MKN45	8.3
Stomach	MKN74	7.1
Stomach	MKN7	8
Stomach	NCCSTCK140	8
Stomach	NCIN87	7.3
Stomach	NUGC2	8.2
Stomach	NUGC3	8.5
Stomach	NUGC4	7.6
Stomach	OCUM1	7.9
Stomach	RERFGC1B	7.5
Stomach	SH10TC	8.4
Stomach	SNU16	8.1
Stomach	SNU1	8.4
Stomach	SNU216	8
Stomach	SNU520	8.1
Stomach	SNU5	8
Stomach	SNU601	9.1
Stomach	SNU620	7.6
Stomach	SNU668	7.8
Stomach	SNU719	8.3
Stomach	TGBC11TKB	7.2
Thyroid	8305C	8.8
Thyroid	8505C	8.2
Thyroid	BCPAP	8.4
Thyroid	BHT101	7.9
Thyroid	CAL62	8.3
Thyroid	CGTHW1	7.6
Thyroid	FTC133	7.4
Thyroid	FTC238	7.6
Thyroid	ML1	6.8
Thyroid	SW579	8.2
Thyroid	TT2609C02	8.1
Thyroid	TT	7.7
Upper aerodigestive tract	BHY	7.2
Upper aerodigestive tract	BICR16	8
Upper aerodigestive tract	BICR18	7.3
Upper aerodigestive tract	BICR22	7.8
Upper aerodigestive tract	BICR31	6.9
Upper aerodigestive tract	BICR56	7.7
Upper aerodigestive tract	BICR6	7.5
Upper aerodigestive tract	CAL27	8
Upper aerodigestive tract	CAL33	7.8
Upper aerodigestive tract	DETROIT562	7.9
Upper aerodigestive tract	FADU	8.5
Upper aerodigestive tract	HS840T	8.1
Upper aerodigestive tract	HSC2	7.6
Upper aerodigestive tract	HSC3	8.1
Upper aerodigestive tract	HSC4	7.6
Upper aerodigestive tract	PECAPJ15	7.2
Upper aerodigestive tract	PECAPJ34CLONEC12	7.6
Upper aerodigestive tract	PECAPJ41CLONED2	7.3
Upper aerodigestive tract	PECAPJ49	7.7
Upper aerodigestive tract	SCC15	7.7
Upper aerodigestive tract	SCC25	8.2
Upper aerodigestive tract	SCC4	7.5
Upper aerodigestive tract	SCC9	7.8
Upper aerodigestive tract	SNU1076	7.4
Upper aerodigestive tract	SNU1214	7.3
Upper aerodigestive tract	SNU46	8
Upper aerodigestive tract	SNU899	7.3
Upper aerodigestive tract	YD10B	8.1
Upper aerodigestive tract	YD38	8
Upper aerodigestive tract	YD8	7.5
Urinary tract	5637	7.9
Urinary tract	639V	8.8
Urinary tract	647V	8.9
Urinary tract	BC3C	8.1
Urinary tract	BFTC905	8.4
Urinary tract	CAL29	7.6
Urinary tract	HS172T	7.4
Urinary tract	HT1197	7.6
Urinary tract	HT1376	7.9
Urinary tract	J82	8.1
Urinary tract	JMSU1	8.9
Urinary tract	KMBC2	8.2
Urinary tract	KU1919	8.2
Urinary tract	RT11284	7.4
Urinary tract	RT112	8.5
Urinary tract	RT4	7.7
Urinary tract	SCABER	7.6
Urinary tract	SW1710	7.2
Urinary tract	SW780	7.4
Urinary tract	T24	7.9
Urinary tract	TCCSUP	9.2
Urinary tract	UMUC1	7.7
Urinary tract	UMUC3	7.9
Urinary tract	VMCUB1	7.5

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	3.1
Adrenal gland	5.5
Appendix	2
Bone marrow	1.9
Breast	2.7
Cerebral cortex	1.7
Cervix, uterine	3
Colon	4
Duodenum	3.8
Endometrium	6.6
Epididymis	19
Esophagus	2.2
Fallopian tube	6.5
Gallbladder	4.7
Heart muscle	1.5
Kidney	1.8
Liver	1
Lung	3.5
Lymph node	3.3
Ovary	5.4
Pancreas	0.6
Parathyroid gland	13.7
Placenta	4
Prostate	2.6
Rectum	5.2
Salivary gland	0.4
Seminal vesicle	6.7
Skeletal muscle	1.7
Skin	4
Small intestine	2.9
Smooth muscle	7.7
Spleen	9.5
Stomach	1.2
Testis	14.2
Thyroid gland	5.9
Tonsil	11.6
Urinary bladder	3

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27407094	Loss of expression	Neuroendocrine Carcinoma	The prevalence of ALT and DAXX/ATRX loss in resected PanNETs was 31% and 26%, respectively, and associated with larger tumor size, higher WHO grade, lymph node metastasis, and distant metastasis (P < 0.001).
27663587	Loss of expression	Neuroendocrine Carcinoma	Similarly, tumors with loss of ATRX/DAXX expression were significantly associated with ALT (P < 0.001), aggressive clinical behavior, and reduced recurrence-free survival (P < 0.001).
27663587	Loss of Expression	Pancreatic Neuroendocrine Tumor	In PanNETs, ALT or loss of ATRX/DAXX nuclear expression was observed in 20.8% and 19.3%, respectively, while microadenomas were not altered.
27407094	Loss of Expression	Pancreatic Neuroendocrine Tumor	ALT and DAXX/ATRX loss in PanNETs was associated with shorter DFS and DSS and likely plays a significant role in driving metastatic disease.
27259015	Loss of Expression	Neuroendocrine Neoplasm	Loss of DAXX or ATRX protein expression defined WD-NET, and abnormal p53, Rb, SMAD4 expression signified PD-NEC.
27162024	Loss of Expression	Pancreatic Neuroendocrine Tumor	Loss of ATRX/DAXX expression is frequent in PanNETs, indicating a role in their pathogenesis.
26814089	Overexpression	Cervical Intraepithelial Neoplasia; cervical Squamous Cell Carcinoma	(1) The positive expression rate of Daxx was 28.57% (12/42), 40.00% (18/45), 65.91% (29/44), 66.67% (42/63), respectively, in chronic cervicitis, cervical intraepithelial neoplasia I-II (CIN I-II), CIN III and cervical squamous cell carcinoma.
26205068	Overexpression	Oral Squamous Cell Carcinoma	Daxx mRNA and protein expression are elevated in several OSCC cell lines and human OSCC samples in comparison to those in normal tissue.
26190196	Loss of Expression	Liver Angiosarcoma; Epithelioid Hemangioendothelioma	Loss of ATRX expression was observed in 21% (16/77) of the primary angiosarcomas and 9% (1/11) of epithelioid hemangioendotheliomas.
26026117	Loss of Expression	Pancreatic Neoplasm	The ALT-positive phenotype was significantly associated with tumors of pancreatic origin (7/10) and loss of ATRX or DAXX protein (8/10).
25903140	Overexpression	Prostate Carcinoma; pancreatic carcinoma	Finally, interrogation of the Oncomine(TM) database suggests that DAXX overexpression is associated with malignant transformation in several human cancers, including prostate and pancreatic cancers.
24436263	Mutation; Loss of Expression	Pancreatic Neuroendocrine Tumor	Mutation in DAXX/ATRX is only seen in pancreatic neuroendocrine tumors, making it a useful potential marker in distinguishing these tumors from mimics. Loss of expression of DAXX and ATRX proteins has been recently identified in 45 %.
24430597	Loss of Expression	Pancreatic Neuroendocrine Tumor	Molecular alterations of PanNETs are also very different than that of ductal or acinar tumors. Loss of expression of DAXX and ATRX proteins has been recently identified in 45 %.
24375391	Mutation; altered expression	Neuroendocrine Neoplasm	Biological understanding and derived treatment options for NETs have changed markedly in recent years. Over the last decade, the genomic landscape of these tumors has been extensively investigated. This has resulted in the discovery of mutations and expression anomalies in genes and pathways such as the PI3K/Akt/mTOR, DAXX/ATRX, and MEN1, which are promising predictive and prognostic biomarkers and future candidates for targeted therapies.
24148618	Loss of Expression	Pancreatic Neuroendocrine Tumor	Loss of DAXX or ATRX protein and alternative lengthening of telomeres were associated with CIN in pNETs.
23954140	Loss of Expression	Neuroendocrine Neoplasm	At least 1 loss of ATRX and DAXX immunoreactivity was detected in all neuroendocrine tumor cases but not in any of nonneoplastic pancreatic tissues or pancreatic adenocarcinomas.
23819605	altered expression	Urothelial Carcinoma	The quantitative immunohistochemical analysis shows an altered protein expression of chromatin remodeler DAXX in UC and in its preinvasive phases, when compared to NU. DAXX evaluation, if associated with markers related to global DNA methylation and histone acetylation, could be used in clinical practice as a marker of aggressiveness.
23642739	Overexpression	Prostate Carcinoma	DAXX expression was analyzed by immunohistochemistry on a tissue microarray containing 7478 prostate cancer specimens. Results were compared with tumor phenotype, biochemical recurrence, and v-ets erythroblastosis virus E26 oncogene homolog (ERG) status. DAXX expression was predominantly seen in the nucleus. DAXX expression was detectable in 4609 (80.6%) of 5718 interpretable cancers and considered strong in 5.9%, moderate in 45.8%, and weak in 28.9%. Strong DAXX expression was associated with both transmembrane protease, serine 2 (TMPRSS2)/ERG rearrangement and ERG expression (P < .0001 each). Strong DAXX expression was tightly linked to high Gleason grade, advanced pT stage, increased cell proliferation index, and early prostate-specific antigen recurrence (P < .0001 each).
23539629	Overexpression	Ovarian Epithelial Tumor	In this study, we found that DAXX was highly expressed in human ovarian surface epithelial tumors but not in granulosa cell tumors.
22575867	Loss of Expression	Pancreatic Carcinoma	ATRX and/or DAXX expression was lost in 3 of 50 (6%) pancreatic neuroendocrine tumors.
22251937	Loss of Expression	Pancreatic Neuroendocrine Tumor	In contrast, DAXX and ATRX labeling was lost in 45% of PanNETs, whereas p53 and Rb immunolabeling was intact in these same cases.
21719641	Mutation; Loss of Expression	Pancreatic Neuroendocrine Tumor	All of the PanNETs exhibiting these abnormal telomeres had ATRX or DAXX mutations or loss of nuclear ATRX or DAXX protein.
17306074	Overexpression	Acute Leukemia	The expression of Daxx protein was detected by immunohistochemical assay in 50 children with newly diagnosed acute leukemia (34 cases of acute lymphocytic leukemia and 16 cases of acute non-lymphocytic leukemia). Daxx protein was expressed in 38.0% of 50 children with acute leukemia, which was significantly higher than that of the control group (5.0%) (P < 0.05).
16101141	Underexpression	Colon adenocarcinoma	A reduction in Daxx protein expression was also observed in colon adenocarcinoma tissue when compared with normal colon tissue.
11358857	Overexpression	Prostate Carcinoma	Some genes (e.g., E2F4) were overexpressed in tumor epithelial cells and some (e.g., Daxx) were increased in tumor stroma.

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.636	3.65e-47	20.8	56.2	23	Neutral
BRCA	Breast invasive carcinoma	1075	0.497	4e-68	13.8	61.9	24.4	Neutral
CESC	Cervical and endocervical cancers	292	0.693	3.42e-43	12.3	63	24.7	Neutral
COAD	Colon adenocarcinoma	449	0.557	5.57e-38	9.4	70.2	20.5	Neutral
ESCA	Esophageal carcinoma	183	0.635	4.77e-22	22.4	50.3	27.3	Neutral
GBM	Glioblastoma multiforme	147	0.484	5.44e-10	17.7	78.2	4.1	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.709	1.19e-79	16	66.3	17.7	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.413	5.06e-23	18.7	79.6	1.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.476	1.04e-17	9.7	88.9	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.172	0.0267	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.412	1.72e-22	4.9	92.8	2.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.591	1.22e-35	3.3	57.4	39.3	Gain
LUAD	Lung adenocarcinoma	512	0.623	2.29e-56	11.9	51.2	36.9	Gain
LUSC	Lung squamous cell carcinoma	498	0.635	1.7e-57	25.3	51	23.7	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.716	2.01e-48	20.3	33.7	46	Gain
PAAD	Pancreatic adenocarcinoma	177	0.51	4.25e-13	32.8	62.1	5.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.353	4.04e-06	1.2	90.1	8.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.183	4.46e-05	4.5	91.9	3.7	Neutral
READ	Rectum adenocarcinoma	164	0.664	3.04e-22	9.1	63.4	27.4	Neutral
SARC	Sarcoma	255	0.508	3.63e-18	26.3	53.3	20.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.668	7.67e-49	8.4	40.6	51	Gain
STAD	Stomach adenocarcinoma	413	0.552	2.58e-34	13.1	64.9	22	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.127	0.123	10	72	18	Neutral
THCA	Thyroid carcinoma	497	0.196	1.02e-05	0.8	98.8	0.4	Neutral
THYM	Thymoma	119	0.291	0.00134	16.8	83.2	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.488	1.89e-33	2.4	78.8	18.8	Neutral

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.35	1.54e-13	17	408	-0.006	0.467	NS/NA
BRCA	Breast invasive carcinoma	-0.251	7.02e-14	83	785	-0.006	0.042	NS/NA
CESC	Cervical and endocervical cancers	-0.392	1.08e-12	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.31	2.16e-08	19	297	0.002	0.991	NS/NA
ESCA	Esophageal carcinoma	-0.385	3.75e-08	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.394	0.00126	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.305	4.76e-13	20	522	0	0.745	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.138	0.0107	24	319	0.004	8.12e-14	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.224	9.91e-05	23	275	0.003	2.58e-08	NS/NA
LAML	Acute Myeloid Leukemia	-0.195	0.0107	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.202	2.84e-06	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.236	1.3e-06	41	373	0.002	0.798	NS/NA
LUAD	Lung adenocarcinoma	-0.274	1.31e-09	21	456	-0.078	2.02e-05	NS/NA
LUSC	Lung squamous cell carcinoma	-0.311	7.63e-10	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.917	0.00131	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.241	0.00102	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.201	0.00591	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.162	0.000183	35	498	0.008	0.269	NS/NA
READ	Rectum adenocarcinoma	-0.394	5.18e-05	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.336	2.86e-08	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.471	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.25	1.11e-06	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.37	2.3e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.167	7.75e-05	50	509	-0.013	0.556	NS/NA
THYM	Thymoma	-0.348	9.59e-05	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.244	1.11e-07	34	431	-0.014	0.308	NS/NA

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	3	High
Bone marrow	2	Medium
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	2	Medium
Colon	2	Medium
Duodenum	2	Medium
Endometrium	1	Low
Epididymis	2	Medium
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	3	High
Nasopharynx	2	Medium
Oral mucosa	2	Medium
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	2	Medium
Prostate	1	Low
Rectum	2	Medium
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	1	Low
Spleen	2	Medium
Stomach	2	Medium
Testis	3	High
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	3	High
Vagina	2	Medium

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.15	NS	24476821
BRCA	Breast invasive carcinoma	521	1.01e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0114	Significant	22810696
GBM	Glioblastoma multiforme	157	0.0191	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	2.04e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0407	Significant	26536169
LGG	Brain Lower Grade Glioma	513	4.02e-05	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.807	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0203	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00251	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00755	Significant	26544944
READ	Rectum adenocarcinoma	67	0.98	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	2.54e-07	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.00102	Significant	25079317
THCA	Thyroid carcinoma	391	0.0702	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	2.81e-07	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.935	0.753	NS
BRCA	Breast invasive carcinoma	1079	0.636	0.0812	NS
CESC	Cervical and endocervical cancers	291	1.238	0.563	NS
COAD	Colon adenocarcinoma	439	2.042	0.0238	Shorter
ESCA	Esophageal carcinoma	184	0.719	0.3	NS
GBM	Glioblastoma multiforme	158	0.658	0.102	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.182	0.389	NS
KIRC	Kidney renal clear cell carcinoma	531	2.01	0.00107	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	2.449	0.0289	Shorter
LAML	Acute Myeloid Leukemia	149	2.719	0.000656	Shorter
LGG	Brain Lower Grade Glioma	511	0.879	0.605	NS
LIHC	Liver hepatocellular carcinoma	365	1.366	0.259	NS
LUAD	Lung adenocarcinoma	502	1.237	0.314	NS
LUSC	Lung squamous cell carcinoma	494	0.871	0.486	NS
OV	Ovarian serous cystadenocarcinoma	303	0.714	0.111	NS
PAAD	Pancreatic adenocarcinoma	177	1.035	0.91	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.093	NS
PRAD	Prostate adenocarcinoma	497	4.151	0.163	NS
READ	Rectum adenocarcinoma	159	0.416	0.0944	NS
SARC	Sarcoma	259	1.133	0.659	NS
SKCM	Skin Cutaneous Melanoma	459	1.433	0.0528	NS
STAD	Stomach adenocarcinoma	388	0.684	0.0942	NS
TGCT	Testicular Germ Cell Tumors	134	0.982	0.99	NS
THCA	Thyroid carcinoma	500	2.051	0.397	NS
THYM	Thymoma	119	0.273	0.105	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.226	0.47	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.129	0.00922	Lower
BRCA	Breast invasive carcinoma	1071	-0.052	0.0895	NS
CESC	Cervical and endocervical cancers	167	-0.133	0.0869	NS
COAD	Colon adenocarcinoma	445	0.124	0.00911	Higher
ESCA	Esophageal carcinoma	162	-0.056	0.477	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.037	0.432	NS
KIRC	Kidney renal clear cell carcinoma	531	0.161	0.000189	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.258	2.48e-05	Higher
LIHC	Liver hepatocellular carcinoma	347	0.085	0.116	NS
LUAD	Lung adenocarcinoma	507	0.031	0.493	NS
LUSC	Lung squamous cell carcinoma	497	-0.028	0.537	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.087	0.132	NS
PAAD	Pancreatic adenocarcinoma	176	0.088	0.244	NS
READ	Rectum adenocarcinoma	156	0.092	0.253	NS
SKCM	Skin Cutaneous Melanoma	410	-0.048	0.334	NS
STAD	Stomach adenocarcinoma	392	-0.109	0.0303	Lower
TGCT	Testicular Germ Cell Tumors	81	-0.093	0.411	NS
THCA	Thyroid carcinoma	499	0.096	0.0325	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.115	0.00978	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.068	0.266	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.011	0.8	NS
KIRC	Kidney renal clear cell carcinoma	525	0.148	0.000654	Higher
LGG	Brain Lower Grade Glioma	514	0.19	1.46e-05	Higher
LIHC	Liver hepatocellular carcinoma	366	0.061	0.241	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.061	0.295	NS
PAAD	Pancreatic adenocarcinoma	176	-0.045	0.552	NS
STAD	Stomach adenocarcinoma	406	-0.144	0.00371	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.414	1.64e-23	Higher

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for DAXX.

Summary
Symbol	DAXX
Name	death domain associated protein
Aliases	DAP6; death-associated protein 6; BING2; CENP-C binding protein; ETS1-associated protein 1; Fas-binding prot ......
Location	6p21.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26205068	Oral Squamous Cell Carcinoma	partner	TCF4	Binding	Daxx silencing reduces cyclin D1 expression via a Daxx-TCF4 interaction, whereas the Daxx depletion-mediated G1 arrest can be relieved by ectopic expression of cyclin D1.
26205068	Oral Squamous Cell Carcinoma	downstream	Cyclin D1	Negative regulation	Daxx silencing reduces cyclin D1 expression via a Daxx-TCF4 interaction, whereas the Daxx depletion-mediated G1 arrest can be relieved by ectopic expression of cyclin D1.
24375391	Neuroendocrine Neoplasm	partner	ATRX	Binding	Biological understanding and derived treatment options for NETs have changed markedly in recent years. Over the last decade, the genomic landscape of these tumors has been extensively investigated. This has resulted in the discovery of mutations and expression anomalies in genes and pathways such as the PI3K/Akt/mTOR, DAXX/ATRX, and MEN1, which are promising predictive and prognostic biomarkers and future candidates for targeted therapies.
23539629	Ovarian Epithelial Tumor	partner	PML	Binding	In cultured ovarian cancer cells, DAXX interacted with promyelocytic leukemia protein (PML) and localized to subnuclear domains (so-called PML nuclear bodies).
16101141	Colon adenocarcinoma	downstream	cyclin D1; Hath-1	Regulation	Overexpression of Daxx altered the expression of genes downstream of Tcf4, including cyclin D1 and Hath-1, and induced G1 phase arrest in colon cancer cells