CR2Cancer

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF01426 BAH domain
PF06464 DMAP1-binding Domain
PF00145 C-5 cytosine-specific DNA methylase
PF12047 Cytosine specific DNA methyltransferase replication foci domain
PF02008 CXXC zinc finger domain

Function

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306).

Classification

Class	Modification	Substrate	Product	PubMed
DNA modification	DNA methylation	dhC	dhU	18754681

> Gene Ontology [ TOP ]
Biological Process	GO:0001101 response to acid chemical GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006342 chromatin silencing GO:0006346 methylation-dependent chromatin silencing GO:0006479 protein methylation GO:0007265 Ras protein signal transduction GO:0008213 protein alkylation GO:0010216 maintenance of DNA methylation GO:0016458 gene silencing GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0031062 positive regulation of histone methylation GO:0031935 regulation of chromatin silencing GO:0031937 positive regulation of chromatin silencing GO:0032259 methylation GO:0032776 DNA methylation on cytosine GO:0034968 histone lysine methylation GO:0040029 regulation of gene expression, epigenetic GO:0043200 response to amino acid GO:0043414 macromolecule methylation GO:0044728 DNA methylation or demethylation GO:0045814 negative regulation of gene expression, epigenetic GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051567 histone H3-K9 methylation GO:0051568 histone H3-K4 methylation GO:0051569 regulation of histone H3-K4 methylation GO:0051570 regulation of histone H3-K9 methylation GO:0051571 positive regulation of histone H3-K4 methylation GO:0051573 negative regulation of histone H3-K9 methylation GO:0060968 regulation of gene silencing GO:0061647 histone H3-K9 modification GO:0071229 cellular response to acid chemical GO:0071230 cellular response to amino acid stimulus GO:0071417 cellular response to organonitrogen compound GO:0090116 C-5 methylation of cytosine GO:0090308 regulation of methylation-dependent chromatin silencing GO:0090309 positive regulation of methylation-dependent chromatin silencing GO:1902275 regulation of chromatin organization GO:1905268 negative regulation of chromatin organization GO:1905269 positive regulation of chromatin organization
Molecular Function	GO:0003682 chromatin binding GO:0003886 DNA (cytosine-5-)-methyltransferase activity GO:0008168 methyltransferase activity GO:0008327 methyl-CpG binding GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0009008 DNA-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:1990841 promoter-specific chromatin binding
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0000792 heterochromatin GO:0005657 replication fork GO:0005721 pericentric heterochromatin GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00270 Cysteine and methionine metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-5334118: DNA methylation R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-427413: NoRC negatively regulates rRNA expression R-HSA-212300: PRC2 methylates histones and DNA

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1680633	c.4801C>T	p.R1601*	Substitution - Nonsense	Large_intestine
COSM5016609	c.1998_1999insAAA	p.K666_C667insK	Insertion - In frame	Kidney
COSM3891424	c.3974C>T	p.P1325L	Substitution - Missense	Skin
COSM4978681	c.2628C>T	p.F876F	Substitution - coding silent	Oesophagus
COSM5933805	c.3347-7C>T	p.?	Unknown	Skin
COSM4469587	c.1560C>T	p.S520S	Substitution - coding silent	Skin
COSM1611470	c.4273A>G	p.M1425V	Substitution - Missense	Liver
COSM1390036	c.566C>T	p.S189L	Substitution - Missense	Large_intestine
COSM3821832	c.3232G>T	p.G1078C	Substitution - Missense	Breast
COSM990449	c.1770C>T	p.V590V	Substitution - coding silent	Endometrium
COSM253711	c.860G>A	p.R287K	Substitution - Missense	Urinary_tract
COSM5678474	c.914A>G	p.E305G	Substitution - Missense	Soft_tissue
COSM4614480	c.4652_4661del10	p.R1551fs*55	Deletion - Frameshift	Large_intestine
COSM3371127	c.2116G>A	p.D706N	Substitution - Missense	Thyroid
COSM3730028	c.2828delC	p.P943fs*14	Deletion - Frameshift	Stomach
COSM1250488	c.1601C>T	p.T534M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM26919	c.4589C>T	p.P1530L	Substitution - Missense	Skin
COSM5388534	c.3691_3692GG>TA	p.G1231Y	Substitution - Missense	Skin
COSM4073749	c.2720T>C	p.I907T	Substitution - Missense	Stomach
COSM266403	c.1294G>A	p.E432K	Substitution - Missense	Large_intestine
COSM1480506	c.2575G>A	p.D859N	Substitution - Missense	Breast
COSM990429	c.4560C>T	p.D1520D	Substitution - coding silent	Endometrium
COSM5493815	c.2395G>A	p.A799T	Substitution - Missense	Biliary_tract
COSM990466	c.151G>A	p.E51K	Substitution - Missense	Endometrium
COSM3733754	c.1875C>G	p.Y625*	Substitution - Nonsense	Pancreas
COSM4533374	c.1927G>A	p.D643N	Substitution - Missense	Skin
COSM1480509	c.414C>T	p.P138P	Substitution - coding silent	Breast
COSM237311	c.4044G>A	p.K1348K	Substitution - coding silent	Prostate
COSM3528104	c.2920C>T	p.R974W	Substitution - Missense	Skin
COSM5706834	c.4435G>A	p.V1479M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM266403	c.1294G>A	p.E432K	Substitution - Missense	Large_intestine
COSM253711	c.860G>A	p.R287K	Substitution - Missense	Urinary_tract
COSM990454	c.1137G>A	p.Q379Q	Substitution - coding silent	Endometrium
COSM4495413	c.4489C>T	p.P1497S	Substitution - Missense	Skin
COSM95829	c.1848G>A	p.T616T	Substitution - coding silent	Prostate
COSM4845110	c.2850C>G	p.I950M	Substitution - Missense	Cervix
COSM990443	c.2787C>T	p.N929N	Substitution - coding silent	Endometrium
COSM3148789	c.2427G>A	p.S809S	Substitution - coding silent	Large_intestine
COSM3891423	c.4417C>T	p.R1473C	Substitution - Missense	Skin
COSM4073747	c.3109G>A	p.A1037T	Substitution - Missense	Stomach
COSM1390020	c.4721G>A	p.R1574Q	Substitution - Missense	Large_intestine
COSM4991201	c.933T>G	p.I311M	Substitution - Missense	Skin
COSM1130015	c.1016G>C	p.R339P	Substitution - Missense	Prostate
COSM3821833	c.2716G>T	p.E906*	Substitution - Nonsense	Breast
COSM5989908	c.3115A>G	p.I1039V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4749841	c.406C>T	p.R136C	Substitution - Missense	Stomach
COSM1630690	c.552T>C	p.S184S	Substitution - coding silent	Liver
COSM1250490	c.276G>T	p.L92F	Substitution - Missense	Oesophagus
COSM5365209	c.3935G>A	p.R1312Q	Substitution - Missense	Large_intestine
COSM990452	c.1435T>C	p.F479L	Substitution - Missense	Endometrium
COSM331850	c.4170G>T	p.G1390G	Substitution - coding silent	Lung
COSM4073752	c.2379C>T	p.H793H	Substitution - coding silent	Stomach
COSM4902209	c.2930C>T	p.S977F	Substitution - Missense	Skin
COSM135812	c.3514C>T	p.P1172S	Substitution - Missense	Skin
COSM3148809	c.1326C>A	p.I442I	Substitution - coding silent	Large_intestine
COSM3528097	c.3737C>T	p.S1246F	Substitution - Missense	Skin
COSM4393829	c.4182C>T	p.S1394S	Substitution - coding silent	Skin
COSM4506764	c.680C>T	p.S227L	Substitution - Missense	Skin
COSM5964371	c.1048C>T	p.P350S	Substitution - Missense	Breast
COSM1390025	c.2152delA	p.M718fs*59	Deletion - Frameshift	Pancreas
COSM4580569	c.3663C>T	p.C1221C	Substitution - coding silent	Bone
COSM5484218	c.533G>A	p.R178Q	Substitution - Missense	Large_intestine
COSM4678885	c.1786C>T	p.R596*	Substitution - Nonsense	Large_intestine
COSM288431	c.4097C>T	p.T1366M	Substitution - Missense	Large_intestine
COSM5019408	c.1584C>A	p.I528I	Substitution - coding silent	Soft_tissue
COSM3528091	c.4396C>T	p.R1466C	Substitution - Missense	Skin
COSM5803900	c.3520G>T	p.A1174S	Substitution - Missense	Liver
COSM5808125	c.3534G>C	p.R1178R	Substitution - coding silent	Liver
COSM1204290	c.2873G>A	p.R958H	Substitution - Missense	Large_intestine
COSM4959999	c.416G>A	p.R139K	Substitution - Missense	Liver
COSM4495140	c.4430C>T	p.S1477F	Substitution - Missense	Skin
COSM77600	c.4145C>T	p.S1382L	Substitution - Missense	Ovary
COSM4950702	c.787G>T	p.D263Y	Substitution - Missense	Liver
COSM4385039	c.4444G>A	p.G1482S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM990447	c.1885G>A	p.D629N	Substitution - Missense	Endometrium
COSM4749835	c.2377C>T	p.H793Y	Substitution - Missense	Stomach
COSM5906428	c.398C>T	p.S133F	Substitution - Missense	Skin
COSM990439	c.3045A>C	p.K1015N	Substitution - Missense	Endometrium
COSM1390030	c.957A>G	p.E319E	Substitution - coding silent	Large_intestine
COSM77600	c.4145C>T	p.S1382L	Substitution - Missense	Lung
COSM94139	c.4652G>A	p.R1551Q	Substitution - Missense	Breast
COSM4773271	c.3446G>T	p.G1149V	Substitution - Missense	Stomach
COSM4453518	c.306A>T	p.E102D	Substitution - Missense	Skin
COSM4950109	c.4570A>G	p.S1524G	Substitution - Missense	Liver
COSM1390033	c.687G>A	p.T229T	Substitution - coding silent	Large_intestine
COSM3528099	c.3670C>T	p.P1224S	Substitution - Missense	Skin
COSM272608	c.768_769delGA	p.K257fs*16	Deletion - Frameshift	Large_intestine
COSM140194	c.1609C>T	p.P537S	Substitution - Missense	Skin
COSM1204290	c.2873G>A	p.R958H	Substitution - Missense	Liver
COSM1750613	c.504A>G	p.T168T	Substitution - coding silent	Urinary_tract
COSM5601375	c.3750C>T	p.S1250S	Substitution - coding silent	Skin
COSM4073750	c.2557T>C	p.S853P	Substitution - Missense	Stomach
COSM4566005	c.2826_2827CC>TT	p.P943S	Substitution - Missense	Skin
COSM3148822	c.387delC	p.K130fs*129	Deletion - Frameshift	Pancreas
COSM266403	c.1294G>A	p.E432K	Substitution - Missense	Skin
COSM5343186	c.1847C>T	p.T616M	Substitution - Missense	Large_intestine
COSM1563983	c.3672G>C	p.P1224P	Substitution - coding silent	Large_intestine
COSM4385040	c.2428G>C	p.D810H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1130019	c.2189G>A	p.R730H	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4544868	c.3606G>A	p.E1202E	Substitution - coding silent	Skin
COSM4566514	c.3945_3946CC>TT	p.(=)	Unknown	Skin
COSM3772482	c.4509C>T	p.T1503T	Substitution - coding silent	Pancreas
COSM3148807	c.1488G>A	p.A496A	Substitution - coding silent	Large_intestine
COSM1204290	c.2873G>A	p.R958H	Substitution - Missense	Large_intestine
COSM1303913	c.541C>G	p.Q181E	Substitution - Missense	Urinary_tract
COSM3528109	c.1052C>T	p.P351L	Substitution - Missense	Skin
COSM3719017	c.30G>T	p.V10V	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1579211	c.1147A>G	p.N383D	Substitution - Missense	Breast
COSM3148794	c.2211C>T	p.A737A	Substitution - coding silent	Large_intestine
COSM3148750	c.4395C>T	p.G1465G	Substitution - coding silent	Large_intestine
COSM990458	c.1068C>T	p.C356C	Substitution - coding silent	Endometrium
COSM3148802	c.1701C>T	p.A567A	Substitution - coding silent	Stomach
COSM4678883	c.2066G>A	p.R689Q	Substitution - Missense	Large_intestine
COSM5046000	c.2999_3001delTCT	p.F1000delF	Deletion - In frame	Oesophagus
COSM1250489	c.2415C>T	p.L805L	Substitution - coding silent	Oesophagus
COSM1318379	c.499A>T	p.I167F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM288125	c.4591G>C	p.E1531Q	Substitution - Missense	Large_intestine
COSM3148826	c.81-8C>T	p.?	Unknown	Skin
COSM3772483	c.3319G>T	p.G1107*	Substitution - Nonsense	Pancreas
COSM237311	c.4044G>A	p.K1348K	Substitution - coding silent	Prostate
COSM3959464	c.4124C>T	p.P1375L	Substitution - Missense	Lung
COSM4415236	c.931A>G	p.I311V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM292254	c.2553C>T	p.P851P	Substitution - coding silent	Large_intestine
COSM1204291	c.737G>A	p.R246Q	Substitution - Missense	Large_intestine
COSM3362626	c.4769T>C	p.L1590S	Substitution - Missense	Kidney
COSM1390032	c.807C>T	p.G269G	Substitution - coding silent	Stomach
COSM1680633	c.4801C>T	p.R1601*	Substitution - Nonsense	Large_intestine
COSM26919	c.4589C>T	p.P1530L	Substitution - Missense	Skin
COSM4443331	c.686C>T	p.T229M	Substitution - Missense	Large_intestine
COSM4749839	c.1856C>T	p.T619I	Substitution - Missense	Stomach
COSM1130019	c.2189G>A	p.R730H	Substitution - Missense	Prostate
COSM3720617	c.4C>T	p.P2S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4427622	c.4340_4341delCA	p.S1447fs*1	Deletion - Frameshift	Oesophagus
COSM4487499	c.319C>T	p.L107L	Substitution - coding silent	Skin
COSM990441	c.2895T>A	p.D965E	Substitution - Missense	Endometrium
COSM990466	c.151G>A	p.E51K	Substitution - Missense	Endometrium
COSM5627497	c.3154G>C	p.D1052H	Substitution - Missense	Oesophagus
COSM266403	c.1294G>A	p.E432K	Substitution - Missense	Large_intestine
COSM1611471	c.3450_3451insG	p.L1151fs*12	Insertion - Frameshift	Liver
COSM4543216	c.3289G>C	p.E1097Q	Substitution - Missense	Skin
COSM4950109	c.4570A>G	p.S1524G	Substitution - Missense	Liver
COSM4580568	c.3912C>T	p.Y1304Y	Substitution - coding silent	Bone
COSM438456	c.3792C>A	p.L1264L	Substitution - coding silent	Breast
COSM1611473	c.417G>T	p.R139S	Substitution - Missense	Liver
COSM5426645	c.3758+8G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4959999	c.416G>A	p.R139K	Substitution - Missense	Liver
COSM1390024	c.2619C>T	p.Y873Y	Substitution - coding silent	Large_intestine
COSM1204295	c.2975G>A	p.R992Q	Substitution - Missense	Large_intestine
COSM4678881	c.2932G>A	p.D978N	Substitution - Missense	Large_intestine
COSM1250492	c.3617C>T	p.S1206F	Substitution - Missense	Stomach
COSM288431	c.4097C>T	p.T1366M	Substitution - Missense	Prostate
COSM94140	c.2339C>T	p.T780M	Substitution - Missense	Lung
COSM3528109	c.1052C>T	p.P351L	Substitution - Missense	Skin
COSM1480507	c.2318C>T	p.P773L	Substitution - Missense	Breast
COSM3148814	c.906delA	p.E303fs*5	Deletion - Frameshift	Oesophagus
COSM317253	c.1719G>T	p.Q573H	Substitution - Missense	Soft_tissue
COSM5493813	c.3128A>G	p.Y1043C	Substitution - Missense	Biliary_tract
COSM4935591	c.3368A>C	p.Q1123P	Substitution - Missense	Liver
COSM990456	c.1073A>G	p.Q358R	Substitution - Missense	Endometrium
COSM239627	c.4039G>A	p.D1347N	Substitution - Missense	Prostate
COSM266403	c.1294G>A	p.E432K	Substitution - Missense	Large_intestine
COSM4073755	c.1246C>T	p.H416Y	Substitution - Missense	Stomach
COSM1390031	c.890G>A	p.R297Q	Substitution - Missense	Large_intestine
COSM3528093	c.4150C>T	p.L1384L	Substitution - coding silent	Skin
COSM4385042	c.47C>T	p.P16L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4678884	c.2015A>G	p.D672G	Substitution - Missense	Large_intestine
COSM3422367	c.2193C>A	p.I731I	Substitution - coding silent	Large_intestine
COSM4494450	c.4286C>T	p.P1429L	Substitution - Missense	Skin
COSM4073751	c.2483T>C	p.I828T	Substitution - Missense	Stomach
COSM5019408	c.1584C>A	p.I528I	Substitution - coding silent	Soft_tissue
COSM4443331	c.686C>T	p.T229M	Substitution - Missense	Thyroid
COSM4678888	c.987delC	p.E331fs*14	Deletion - Frameshift	Large_intestine
COSM4950702	c.787G>T	p.D263Y	Substitution - Missense	Liver
COSM1303914	c.508C>G	p.H170D	Substitution - Missense	Urinary_tract
COSM474093	c.4520A>G	p.H1507R	Substitution - Missense	Kidney
COSM474097	c.647C>A	p.P216Q	Substitution - Missense	Kidney
COSM4627614	c.2981G>A	p.G994D	Substitution - Missense	Large_intestine
COSM5558342	c.2943A>T	p.K981N	Substitution - Missense	Prostate
COSM990462	c.497C>T	p.T166I	Substitution - Missense	Endometrium
COSM3528092	c.4246-1G>A	p.?	Unknown	Skin
COSM4484084	c.2721C>T	p.I907I	Substitution - coding silent	Skin
COSM148505	c.290A>G	p.H97R	Substitution - Missense	Stomach
COSM3528108	c.1093C>T	p.L365F	Substitution - Missense	Skin
COSM5474035	c.816T>G	p.A272A	Substitution - coding silent	Large_intestine
COSM5388532	c.4294C>T	p.P1432S	Substitution - Missense	Skin
COSM3371126	c.4027G>A	p.V1343M	Substitution - Missense	Small_intestine
COSM266403	c.1294G>A	p.E432K	Substitution - Missense	Large_intestine
COSM5004309	c.245T>C	p.V82A	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM990427	c.4766G>A	p.G1589D	Substitution - Missense	Endometrium
COSM5571625	c.1670T>C	p.V557A	Substitution - Missense	Prostate
COSM3528094	c.4021C>T	p.L1341L	Substitution - coding silent	Skin
COSM4385551	c.4753G>A	p.A1585T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4073743	c.3996C>T	p.H1332H	Substitution - coding silent	Stomach
COSM380934	c.1266C>T	p.I422I	Substitution - coding silent	Lung
COSM1189865	c.1915G>T	p.D639Y	Substitution - Missense	Lung
COSM990435	c.4358G>T	p.R1453M	Substitution - Missense	Endometrium
COSM1303910	c.3531C>T	p.F1177F	Substitution - coding silent	Urinary_tract
COSM990445	c.2364C>T	p.N788N	Substitution - coding silent	Endometrium
COSM438455	c.4036G>C	p.D1346H	Substitution - Missense	Breast
COSM4909597	c.4129G>A	p.V1377M	Substitution - Missense	Liver
COSM5365209	c.3935G>A	p.R1312Q	Substitution - Missense	Large_intestine
COSM4749833	c.3488C>T	p.T1163M	Substitution - Missense	Stomach
COSM1611472	c.1897G>A	p.A633T	Substitution - Missense	Liver
COSM3528105	c.2551C>T	p.P851S	Substitution - Missense	Skin
COSM4950298	c.844G>T	p.D282Y	Substitution - Missense	Liver
COSM3371126	c.4027G>A	p.V1343M	Substitution - Missense	Thyroid
COSM5590645	c.2299C>T	p.P767S	Substitution - Missense	Skin
COSM5004582	c.755+1G>A	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM990431	c.4456G>A	p.D1486N	Substitution - Missense	Endometrium
COSM5789963	c.2789G>T	p.G930V	Substitution - Missense	Breast
COSM3692294	c.411G>A	p.T137T	Substitution - coding silent	Large_intestine
COSM5047349	c.652C>A	p.P218T	Substitution - Missense	Oesophagus
COSM4956602	c.1744C>T	p.R582W	Substitution - Missense	Liver
COSM401802	c.3G>T	p.M1I	Substitution - Missense	Lung
COSM3148794	c.2211C>T	p.A737A	Substitution - coding silent	Large_intestine
COSM4073746	c.3691G>T	p.G1231C	Substitution - Missense	Liver
COSM160549	c.2961C>G	p.A987A	Substitution - coding silent	Breast
COSM5987059	c.2743G>A	p.E915K	Substitution - Missense	Salivary_gland
COSM1284575	c.1372C>A	p.L458I	Substitution - Missense	Autonomic_ganglia
COSM474094	c.3886T>C	p.F1296L	Substitution - Missense	Kidney
COSM4131138	c.45C>A	p.V15V	Substitution - coding silent	Thyroid
COSM1303912	c.1164C>G	p.I388M	Substitution - Missense	Urinary_tract
COSM4678886	c.1537G>A	p.V513M	Substitution - Missense	Large_intestine
COSM3891426	c.1262C>T	p.P421L	Substitution - Missense	Skin
COSM3821835	c.1527C>A	p.S509R	Substitution - Missense	Breast
COSM990466	c.151G>A	p.E51K	Substitution - Missense	Endometrium
COSM1390032	c.807C>T	p.G269G	Substitution - coding silent	Large_intestine
COSM4073758	c.633A>G	p.E211E	Substitution - coding silent	Stomach
COSM4073753	c.1938C>T	p.N646N	Substitution - coding silent	Stomach
COSM3148801	c.1759C>A	p.L587M	Substitution - Missense	Large_intestine
COSM3528107	c.1117G>A	p.D373N	Substitution - Missense	Skin
COSM4623811	c.4287C>A	p.P1429P	Substitution - coding silent	Large_intestine
COSM990433	c.4394G>A	p.G1465D	Substitution - Missense	Endometrium
COSM239627	c.4039G>A	p.D1347N	Substitution - Missense	Prostate
COSM3422368	c.679T>G	p.S227A	Substitution - Missense	Large_intestine
COSM5019907	c.527C>T	p.A176V	Substitution - Missense	Soft_tissue
COSM1130017	c.1747G>A	p.D583N	Substitution - Missense	Prostate
COSM4140202	c.2601G>C	p.L867L	Substitution - coding silent	Ovary
COSM1204293	c.2105A>T	p.D702V	Substitution - Missense	Large_intestine
COSM1390023	c.2875C>T	p.P959S	Substitution - Missense	Large_intestine
COSM710263	c.3303C>A	p.N1101K	Substitution - Missense	Lung
COSM1390022	c.3237C>T	p.G1079G	Substitution - coding silent	Large_intestine
COSM710262	c.2507A>T	p.Y836F	Substitution - Missense	Lung
COSM5019408	c.1584C>A	p.I528I	Substitution - coding silent	Soft_tissue
COSM5365012	c.3235G>A	p.G1079S	Substitution - Missense	Large_intestine
COSM5511012	c.3854G>A	p.R1285H	Substitution - Missense	Biliary_tract
COSM4956602	c.1744C>T	p.R582W	Substitution - Missense	Liver
COSM5470867	c.282C>T	p.N94N	Substitution - coding silent	Large_intestine
COSM4991198	c.3868A>T	p.M1290L	Substitution - Missense	Skin
COSM4277296	c.395T>C	p.L132P	Substitution - Missense	Large_intestine
COSM5056166	c.2365G>A	p.G789R	Substitution - Missense	Stomach
COSM4415236	c.931A>G	p.I311V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4425455	c.1918G>A	p.D640N	Substitution - Missense	Oesophagus
COSM710264	c.3386A>G	p.E1129G	Substitution - Missense	Lung
COSM317253	c.1719G>T	p.Q573H	Substitution - Missense	Lung
COSM3891425	c.1884C>T	p.F628F	Substitution - coding silent	Skin
COSM4823681	c.935C>T	p.S312F	Substitution - Missense	Cervix
COSM474096	c.2088G>A	p.M696I	Substitution - Missense	Kidney
COSM3712764	c.2813G>T	p.G938V	Substitution - Missense	Upper_aerodigestive_tract
COSM1303911	c.1408G>A	p.D470N	Substitution - Missense	Urinary_tract
COSM1390021	c.4146G>A	p.S1382S	Substitution - coding silent	Large_intestine
COSM4140202	c.2601G>C	p.L867L	Substitution - coding silent	Ovary
COSM5019408	c.1584C>A	p.I528I	Substitution - coding silent	Soft_tissue
COSM990460	c.897C>T	p.P299P	Substitution - coding silent	Endometrium
COSM4542475	c.3144G>A	p.E1048E	Substitution - coding silent	Skin
COSM1204294	c.4283T>A	p.I1428N	Substitution - Missense	Large_intestine
COSM1680633	c.4801C>T	p.R1601*	Substitution - Nonsense	Large_intestine
COSM280552	c.3710C>T	p.S1237L	Substitution - Missense	Large_intestine
COSM3148794	c.2211C>T	p.A737A	Substitution - coding silent	Large_intestine
COSM990464	c.369A>G	p.A123A	Substitution - coding silent	Endometrium
COSM143603	c.2960_2961CC>TT	p.A987V	Substitution - Missense	Skin
COSM5019408	c.1584C>A	p.I528I	Substitution - coding silent	Soft_tissue
COSM3148814	c.906delA	p.E303fs*5	Deletion - Frameshift	Oesophagus
COSM5641648	c.1063C>A	p.Q355K	Substitution - Missense	Oesophagus
COSM4073744	c.3739C>T	p.L1247L	Substitution - coding silent	Stomach
COSM310680	c.2381C>T	p.A794V	Substitution - Missense	Lung
COSM334101	c.858C>T	p.H286H	Substitution - coding silent	Lung
COSM4841146	c.1904A>C	p.Q635P	Substitution - Missense	Cervix
COSM4397275	c.2354A>G	p.D785G	Substitution - Missense	Skin
COSM4488283	c.3255C>T	p.F1085F	Substitution - coding silent	Skin
COSM4073748	c.3088T>C	p.S1030P	Substitution - Missense	Stomach
COSM3528090	c.4590C>T	p.P1530P	Substitution - coding silent	Skin
COSM4678880	c.4277G>A	p.R1426Q	Substitution - Missense	Large_intestine
COSM4991197	c.4481C>T	p.T1494I	Substitution - Missense	Skin
COSM4495413	c.4489C>T	p.P1497S	Substitution - Missense	Skin
COSM234638	c.4677C>T	p.F1559F	Substitution - coding silent	Skin
COSM4385038	c.4479C>A	p.N1493K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5365012	c.3235G>A	p.G1079S	Substitution - Missense	Large_intestine
COSM1250488	c.1601C>T	p.T534M	Substitution - Missense	Stomach
COSM5056165	c.2931C>T	p.S977S	Substitution - coding silent	Stomach
COSM5550032	c.1487C>T	p.A496V	Substitution - Missense	Prostate
COSM5741416	c.2213T>C	p.V738A	Substitution - Missense	Small_intestine
COSM160548	c.929A>G	p.Q310R	Substitution - Missense	Breast
COSM4385041	c.850A>C	p.K284Q	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3388534	c.3044A>G	p.K1015R	Substitution - Missense	Pancreas
COSM4073754	c.1282G>A	p.E428K	Substitution - Missense	Stomach
COSM4493971	c.4200C>T	p.L1400L	Substitution - coding silent	Skin
COSM4073746	c.3691G>T	p.G1231C	Substitution - Missense	Stomach
COSM1611470	c.4273A>G	p.M1425V	Substitution - Missense	Liver
COSM4415236	c.931A>G	p.I311V	Substitution - Missense	Oesophagus
COSM3821834	c.2353G>A	p.D785N	Substitution - Missense	Breast
COSM4073756	c.1054A>G	p.K352E	Substitution - Missense	Stomach
COSM260531	c.1453G>A	p.E485K	Substitution - Missense	Large_intestine
COSM4073757	c.898G>A	p.E300K	Substitution - Missense	Stomach
COSM5933803	c.1559C>T	p.S520F	Substitution - Missense	Skin
COSM5988642	c.1720C>T	p.P574S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3528106	c.2268C>T	p.T756T	Substitution - coding silent	Skin
COSM1166698	c.4309C>T	p.R1437C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5019408	c.1584C>A	p.I528I	Substitution - coding silent	Soft_tissue
COSM4640174	c.529A>C	p.K177Q	Substitution - Missense	Large_intestine
COSM1750613	c.504A>G	p.T168T	Substitution - coding silent	Urinary_tract
COSM1204292	c.3937G>A	p.A1313T	Substitution - Missense	Large_intestine
COSM383935	c.3480C>T	p.I1160I	Substitution - coding silent	Lung
COSM4398980	c.1941C>T	p.A647A	Substitution - coding silent	Skin
COSM3970659	c.3532C>T	p.R1178W	Substitution - Missense	Central_nervous_system
COSM1390025	c.2152delA	p.M718fs*59	Deletion - Frameshift	Stomach
COSM4678882	c.2817G>A	p.V939V	Substitution - coding silent	Large_intestine
COSM5781143	c.1951C>T	p.R651W	Substitution - Missense	Breast
COSM990443	c.2787C>T	p.N929N	Substitution - coding silent	Endometrium
COSM4991202	c.844G>A	p.D282N	Substitution - Missense	Skin
COSM70507	c.1567A>G	p.T523A	Substitution - Missense	Ovary
COSM3148799	c.1809C>T	p.T603T	Substitution - coding silent	Large_intestine
COSM3528096	c.3831C>T	p.S1277S	Substitution - coding silent	Skin
COSM5572897	c.2971T>C	p.Y991H	Substitution - Missense	Prostate
COSM990437	c.3620G>A	p.R1207H	Substitution - Missense	Endometrium
COSM3528102	c.3271G>T	p.A1091S	Substitution - Missense	Skin
COSM4166737	c.2520C>T	p.S840S	Substitution - coding silent	Pituitary
COSM5019408	c.1584C>A	p.I528I	Substitution - coding silent	Soft_tissue
COSM4678887	c.1480G>C	p.E494Q	Substitution - Missense	Large_intestine
COSM3403703	c.447T>C	p.P149P	Substitution - coding silent	Central_nervous_system
COSM5819940	c.3023G>A	p.R1008K	Substitution - Missense	Liver
COSM438457	c.2505C>T	p.I835I	Substitution - coding silent	Breast
COSM1238710	c.1696G>A	p.E566K	Substitution - Missense	Oesophagus
COSM5989790	c.382C>A	p.P128T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4991199	c.2341G>A	p.A781T	Substitution - Missense	Skin
COSM4140201	c.3951C>T	p.A1317A	Substitution - coding silent	Ovary
COSM3403702	c.2982C>T	p.G994G	Substitution - coding silent	Central_nervous_system
COSM4073745	c.3701G>A	p.R1234H	Substitution - Missense	Stomach
COSM4485006	c.2835C>T	p.A945A	Substitution - coding silent	Skin
COSM3796554	c.4485C>T	p.L1495L	Substitution - coding silent	Urinary_tract
COSM3148771	c.3419G>A	p.R1140Q	Substitution - Missense	Stomach
COSM239627	c.4039G>A	p.D1347N	Substitution - Missense	Prostate
COSM3712764	c.2813G>T	p.G938V	Substitution - Missense	Upper_aerodigestive_tract
COSM5007076	c.2257G>C	p.D753H	Substitution - Missense	Large_intestine
COSM328005	c.996-9_996-8delTT	p.?	Unknown	Pancreas
COSM3692295	c.112G>T	p.E38*	Substitution - Nonsense	Large_intestine
COSM160547	c.3002G>T	p.C1001F	Substitution - Missense	Breast
COSM4277292	c.996-8T>C	p.?	Unknown	Skin
COSM710261	c.1145C>G	p.T382R	Substitution - Missense	Lung
COSM1480506	c.2575G>A	p.D859N	Substitution - Missense	Bone
COSM3528100	c.3526G>A	p.A1176T	Substitution - Missense	Skin
COSM5464377	c.1293C>T	p.I431I	Substitution - coding silent	Large_intestine
COSM5019408	c.1584C>A	p.I528I	Substitution - coding silent	Soft_tissue
COSM3959465	c.658G>C	p.E220Q	Substitution - Missense	Lung
COSM5042422	c.1840G>A	p.G614R	Substitution - Missense	Liver
COSM3148809	c.1326C>A	p.I442I	Substitution - coding silent	Large_intestine
COSM3362627	c.887A>G	p.K296R	Substitution - Missense	Kidney
COSM4950298	c.844G>T	p.D282Y	Substitution - Missense	Liver
COSM4991200	c.2188C>T	p.R730C	Substitution - Missense	Skin
COSM3528103	c.3124C>T	p.L1042F	Substitution - Missense	Skin
COSM4493814	c.4167C>T	p.N1389N	Substitution - coding silent	Skin
COSM3736188	c.3404A>G	p.K1135R	Substitution - Missense	Skin
COSM3528098	c.3671C>T	p.P1224L	Substitution - Missense	Skin
COSM1238711	c.2262G>A	p.A754A	Substitution - coding silent	Oesophagus
COSM4277292	c.996-8T>C	p.?	Unknown	Skin
COSM1250491	c.3247T>A	p.F1083I	Substitution - Missense	Stomach
COSM3528095	c.3973C>T	p.P1325S	Substitution - Missense	Skin
COSM260531	c.1453G>A	p.E485K	Substitution - Missense	Endometrium
COSM3528101	c.3318T>C	p.P1106P	Substitution - coding silent	Skin
COSM474095	c.2702A>C	p.E901A	Substitution - Missense	Kidney
COSM5741414	c.4333C>T	p.R1445W	Substitution - Missense	Small_intestine
COSM1611472	c.1897G>A	p.A633T	Substitution - Missense	Liver
COSM4745731	c.3739C>G	p.L1247V	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3148777	c.3107A>G	p.H1036R	Substitution - Missense	Large_intestine
COSM5474033	c.3380C>T	p.P1127L	Substitution - Missense	Large_intestine
COSM5019877	c.2645C>T	p.T882I	Substitution - Missense	Soft_tissue
COSM237311	c.4044G>A	p.K1348K	Substitution - coding silent	Prostate
COSM1611473	c.417G>T	p.R139S	Substitution - Missense	Liver
COSM1204290	c.2873G>A	p.R958H	Substitution - Missense	Large_intestine
COSM5019408	c.1584C>A	p.I528I	Substitution - coding silent	Soft_tissue
COSM288125	c.4591G>C	p.E1531Q	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for DNMT1.

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P26358	127	S	Phosphoserine	-	No	None detected
P26358	133	S	Phosphoserine	-	No	None detected
P26358	137	T	Phosphothreonine	-	No	None detected
P26358	141	S	Phosphoserine	-	No	None detected
P26358	142	K	N6-methyllysine	SETD7	No	None detected
P26358	143	S	Phosphoserine	PKB/AKT1	No	None detected
P26358	152	S	Phosphoserine	-	No	None detected
P26358	154	S	Phosphoserine	-	No	None detected
P26358	160	K	N6-acetyllysine	-	No	None detected
P26358	166	T	Phosphothreonine	-	Yes	p.T166I (cancer: UCEC)
P26358	173	K	N6-acetyllysine	-	No	None detected
P26358	188	K	N6-acetyllysine	-	No	None detected
P26358	259	K	N6-acetyllysine	-	No	None detected
P26358	312	S	Phosphoserine	-	Yes	p.S312F (cancer: CESC)
P26358	366	K	N6-acetyllysine	-	No	None detected
P26358	394	S	Phosphoserine	-	No	None detected
P26358	398	S	Phosphoserine	-	No	None detected
P26358	509	S	Phosphoserine	-	Yes	p.S509R (cancer: BRCA)
P26358	549	S	Phosphoserine	-	No	None detected
P26358	714	S	Phosphoserine	-	No	None detected
P26358	732	S	Phosphoserine	-	No	None detected
P26358	749	K	N6-acetyllysine	-	No	None detected
P26358	878	S	Phosphoserine	-	No	None detected
P26358	891	K	N6-acetyllysine	-	No	None detected
P26358	957	K	N6-acetyllysine	-	No	None detected
P26358	961	K	N6-acetyllysine	-	No	None detected
P26358	975	K	N6-acetyllysine	-	No	None detected
P26358	1054	K	N6-acetyllysine	-	No	None detected
P26358	1111	K	N6-acetyllysine	-	No	None detected
P26358	1113	K	N6-acetyllysine	-	No	None detected
P26358	1115	K	N6-acetyllysine	-	No	None detected
P26358	1117	K	N6-acetyllysine	EHMT2	No	None detected
P26358	1119	K	N6-acetyllysine	-	No	None detected
P26358	1121	K	N6-acetyllysine	-	No	None detected
P26358	1349	K	N6-acetyllysine	-	No	None detected
P26358	1415	K	N6-acetyllysine	-	No	None detected

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.451	6.489	1.014	1.4e-07	Over
BRCA	Breast invasive carcinoma	112	1100	5.723	6.638	1.029	6.34e-55	Over
CESC	Cervical and endocervical cancers	3	306	5.107	7.409	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.887	6.734	0.927	8e-21	Over
ESCA	Esophageal carcinoma	11	185	5.45	6.874	1.345	1.95e-09	Over
GBM	Glioblastoma multiforme	5	166	5.767	6.435	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.896	6.712	0.962	8.25e-18	Over
KIRC	Kidney renal clear cell carcinoma	72	534	5.028	5.357	0.313	4.6e-06	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.092	5.244	0.194	0.0709	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.67	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.286	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.803	4.866	1.072	3.07e-15	Over
LUAD	Lung adenocarcinoma	59	517	5.612	6.288	0.779	1.08e-15	Over
LUSC	Lung squamous cell carcinoma	51	501	5.649	6.8	1.164	3.19e-27	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.486	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.727	5.726	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.826	5.449	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.07	5.132	0.08	0.302	NS
READ	Rectum adenocarcinoma	10	167	5.963	6.615	0.967	1.08e-05	Over
SARC	Sarcoma	2	263	4.776	6.746	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.937	7.015	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.657	6.609	1.132	6.77e-21	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.926	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.086	5.837	0.598	3.66e-18	Over
THYM	Thymoma	2	120	7.227	7.093	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.518	6.842	1.3	6.54e-21	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	12.1
Autonomic ganglia	CHP212	11.6
Autonomic ganglia	IMR32	12.1
Autonomic ganglia	KELLY	11.9
Autonomic ganglia	KPNRTBM1	12
Autonomic ganglia	KPNSI9S	11.4
Autonomic ganglia	KPNYN	12.4
Autonomic ganglia	MHHNB11	10.8
Autonomic ganglia	NB1	12
Autonomic ganglia	NH6	11.9
Autonomic ganglia	SHSY5Y	11.5
Autonomic ganglia	SIMA	12
Autonomic ganglia	SKNAS	11.4
Autonomic ganglia	SKNBE2	12
Autonomic ganglia	SKNDZ	12
Autonomic ganglia	SKNFI	11.7
Autonomic ganglia	SKNSH	11.4
Biliary tract	HUCCT1	11.5
Biliary tract	HUH28	11.6
Biliary tract	SNU1079	11.3
Biliary tract	SNU1196	11.3
Biliary tract	SNU245	11.1
Biliary tract	SNU308	11.1
Biliary tract	SNU478	11.9
Bone	143B	12.5
Bone	A673	12.2
Bone	CADOES1	11.2
Bone	CAL78	11.3
Bone	G292CLONEA141B1	12.2
Bone	HOS	12
Bone	HS706T	11.1
Bone	HS737T	10.3
Bone	HS819T	10.2
Bone	HS821T	10.4
Bone	HS822T	9.5
Bone	HS863T	11
Bone	HS870T	10.9
Bone	HS888T	11.4
Bone	MG63	12.9
Bone	MHHES1	11.8
Bone	OUMS27	11.9
Bone	RDES	12.1
Bone	SJSA1	11.8
Bone	SKES1	11.6
Bone	SKNMC	12.5
Bone	SW1353	11.4
Bone	T173	11
Bone	TC71	12.2
Bone	U2OS	11.7
Breast	AU565	11
Breast	BT20	11.3
Breast	BT474	12.1
Breast	BT483	10.3
Breast	BT549	11.6
Breast	CAL120	11
Breast	CAL148	12.1
Breast	CAL51	11.8
Breast	CAL851	11.1
Breast	CAMA1	11.5
Breast	DU4475	12.8
Breast	EFM192A	10.9
Breast	EFM19	11.7
Breast	EVSAT	11.4
Breast	HCC1143	11.8
Breast	HCC1187	12
Breast	HCC1395	11.2
Breast	HCC1419	11.2
Breast	HCC1428	11.3
Breast	HCC1500	10.7
Breast	HCC1569	11.5
Breast	HCC1599	10.9
Breast	HCC1806	11.1
Breast	HCC1937	11.8
Breast	HCC1954	11.4
Breast	HCC202	11.2
Breast	HCC2157	11.9
Breast	HCC2218	11
Breast	HCC38	11.7
Breast	HCC70	11.7
Breast	HDQP1	12
Breast	HMC18	11.5
Breast	HS274T	10.8
Breast	HS281T	11.2
Breast	HS343T	11.3
Breast	HS578T	11.1
Breast	HS606T	10.8
Breast	HS739T	10.6
Breast	HS742T	9.4
Breast	JIMT1	11.6
Breast	KPL1	11.8
Breast	MCF7	11.4
Breast	MDAMB134VI	10.9
Breast	MDAMB157	11.8
Breast	MDAMB175VII	10.8
Breast	MDAMB231	12
Breast	MDAMB361	11.5
Breast	MDAMB415	10.3
Breast	MDAMB436	11.5
Breast	MDAMB453	12
Breast	MDAMB468	13
Breast	SKBR3	10.9
Breast	T47D	11.1
Breast	UACC812	11.1
Breast	UACC893	11
Breast	YMB1	10.8
Breast	ZR751	10.2
Breast	ZR7530	10.6
Central nervous system	1321N1	11.8
Central nervous system	42MGBA	11.7
Central nervous system	8MGBA	11.6
Central nervous system	A172	11.4
Central nervous system	AM38	12.1
Central nervous system	BECKER	11.6
Central nervous system	CAS1	11.1
Central nervous system	CCFSTTG1	12.2
Central nervous system	D283MED	12.3
Central nervous system	D341MED	11
Central nervous system	DAOY	12
Central nervous system	DBTRG05MG	10.2
Central nervous system	DKMG	11.2
Central nervous system	GAMG	11.3
Central nervous system	GB1	11.7
Central nervous system	GI1	12
Central nervous system	GMS10	11.8
Central nervous system	GOS3	11.7
Central nervous system	H4	11.3
Central nervous system	HS683	11.7
Central nervous system	KALS1	11.4
Central nervous system	KG1C	10.7
Central nervous system	KNS42	11.9
Central nervous system	KNS60	11.3
Central nervous system	KNS81	11.2
Central nervous system	KS1	12
Central nervous system	LN18	11.7
Central nervous system	LN229	12
Central nervous system	M059K	11.7
Central nervous system	MOGGCCM	11.6
Central nervous system	MOGGUVW	11.7
Central nervous system	NMCG1	11.3
Central nervous system	ONS76	12
Central nervous system	SF126	11.3
Central nervous system	SF295	12
Central nervous system	SNB19	12
Central nervous system	SNU1105	11.4
Central nervous system	SNU201	10.9
Central nervous system	SNU466	11.2
Central nervous system	SNU489	10.6
Central nervous system	SNU626	11.3
Central nervous system	SNU738	11.3
Central nervous system	SW1088	11.4
Central nervous system	SW1783	11.4
Central nervous system	T98G	11.2
Central nervous system	TM31	11.3
Central nervous system	U118MG	12
Central nervous system	U138MG	12.1
Central nervous system	U251MG	11
Central nervous system	U87MG	11.2
Central nervous system	YH13	11.7
Central nervous system	YKG1	11.6
Endometrium	AN3CA	11.7
Endometrium	COLO684	12.4
Endometrium	EFE184	10.5
Endometrium	EN	11.4
Endometrium	ESS1	11.8
Endometrium	HEC108	11.1
Endometrium	HEC151	11.7
Endometrium	HEC1A	11.6
Endometrium	HEC1B	11.3
Endometrium	HEC251	11.7
Endometrium	HEC265	11.7
Endometrium	HEC50B	11.8
Endometrium	HEC59	11.5
Endometrium	HEC6	11.8
Endometrium	ISHIKAWAHERAKLIO02ER	11.8
Endometrium	JHUEM1	11
Endometrium	JHUEM2	11.6
Endometrium	JHUEM3	10.9
Endometrium	KLE	11.8
Endometrium	MFE280	11.3
Endometrium	MFE296	11.7
Endometrium	MFE319	11.3
Endometrium	RL952	11.5
Endometrium	SNGM	10.9
Endometrium	SNU1077	10.6
Endometrium	SNU685	10.8
Endometrium	TEN	11.8
Haematopoietic and lymphoid	697	12.2
Haematopoietic and lymphoid	A3KAW	11.8
Haematopoietic and lymphoid	A4FUK	11.7
Haematopoietic and lymphoid	ALLSIL	12.9
Haematopoietic and lymphoid	AML193	12
Haematopoietic and lymphoid	AMO1	12.3
Haematopoietic and lymphoid	BCP1	12.1
Haematopoietic and lymphoid	BDCM	11.9
Haematopoietic and lymphoid	BL41	12.8
Haematopoietic and lymphoid	BL70	13.1
Haematopoietic and lymphoid	BV173	12.5
Haematopoietic and lymphoid	CA46	12
Haematopoietic and lymphoid	CI1	12.6
Haematopoietic and lymphoid	CMK115	12.4
Haematopoietic and lymphoid	CMK86	12
Haematopoietic and lymphoid	CMK	12.1
Haematopoietic and lymphoid	CMLT1	11.9
Haematopoietic and lymphoid	COLO775	11.4
Haematopoietic and lymphoid	DAUDI	12.6
Haematopoietic and lymphoid	DB	12.7
Haematopoietic and lymphoid	DEL	11.1
Haematopoietic and lymphoid	DND41	12.6
Haematopoietic and lymphoid	DOHH2	13.3
Haematopoietic and lymphoid	EB1	11.3
Haematopoietic and lymphoid	EB2	11
Haematopoietic and lymphoid	EHEB	11
Haematopoietic and lymphoid	EJM	11.9
Haematopoietic and lymphoid	EM2	12.1
Haematopoietic and lymphoid	EOL1	12.9
Haematopoietic and lymphoid	F36P	11.9
Haematopoietic and lymphoid	GA10	12.5
Haematopoietic and lymphoid	GDM1	12.1
Haematopoietic and lymphoid	GRANTA519	12
Haematopoietic and lymphoid	HDLM2	11.5
Haematopoietic and lymphoid	HDMYZ	11.7
Haematopoietic and lymphoid	HEL9217	13.1
Haematopoietic and lymphoid	HEL	12.9
Haematopoietic and lymphoid	HH	12.1
Haematopoietic and lymphoid	HL60	11.6
Haematopoietic and lymphoid	HPBALL	12.7
Haematopoietic and lymphoid	HS604T	10.1
Haematopoietic and lymphoid	HS611T	12.3
Haematopoietic and lymphoid	HS616T	10.4
Haematopoietic and lymphoid	HS751T	11
Haematopoietic and lymphoid	HT	12.7
Haematopoietic and lymphoid	HTK	11.8
Haematopoietic and lymphoid	HUNS1	12.1
Haematopoietic and lymphoid	HUT102	11.5
Haematopoietic and lymphoid	HUT78	12.3
Haematopoietic and lymphoid	JEKO1	12.7
Haematopoietic and lymphoid	JK1	11.3
Haematopoietic and lymphoid	JM1	12.3
Haematopoietic and lymphoid	JURKAT	11.4
Haematopoietic and lymphoid	JURLMK1	12
Haematopoietic and lymphoid	JVM2	10.5
Haematopoietic and lymphoid	JVM3	11.1
Haematopoietic and lymphoid	K562	11.7
Haematopoietic and lymphoid	KARPAS299	11.7
Haematopoietic and lymphoid	KARPAS422	11.8
Haematopoietic and lymphoid	KARPAS620	12.2
Haematopoietic and lymphoid	KASUMI1	12
Haematopoietic and lymphoid	KASUMI2	12.5
Haematopoietic and lymphoid	KASUMI6	11.8
Haematopoietic and lymphoid	KCL22	12.3
Haematopoietic and lymphoid	KE37	12.5
Haematopoietic and lymphoid	KE97	11.9
Haematopoietic and lymphoid	KG1	12.2
Haematopoietic and lymphoid	KHM1B	12.4
Haematopoietic and lymphoid	KIJK	11.8
Haematopoietic and lymphoid	KMH2	12.2
Haematopoietic and lymphoid	KMM1	12.2
Haematopoietic and lymphoid	KMS11	11.9
Haematopoietic and lymphoid	KMS12BM	12
Haematopoietic and lymphoid	KMS18	12.1
Haematopoietic and lymphoid	KMS20	12.2
Haematopoietic and lymphoid	KMS21BM	11.6
Haematopoietic and lymphoid	KMS26	11.5
Haematopoietic and lymphoid	KMS27	12.3
Haematopoietic and lymphoid	KMS28BM	11.9
Haematopoietic and lymphoid	KMS34	12.1
Haematopoietic and lymphoid	KO52	11.9
Haematopoietic and lymphoid	KOPN8	12.5
Haematopoietic and lymphoid	KU812	12
Haematopoietic and lymphoid	KYO1	11.7
Haematopoietic and lymphoid	L1236	11.6
Haematopoietic and lymphoid	L363	11.8
Haematopoietic and lymphoid	L428	12
Haematopoietic and lymphoid	L540	11.8
Haematopoietic and lymphoid	LAMA84	11.8
Haematopoietic and lymphoid	LOUCY	12.2
Haematopoietic and lymphoid	LP1	10.5
Haematopoietic and lymphoid	M07E	11.8
Haematopoietic and lymphoid	MC116	12.8
Haematopoietic and lymphoid	ME1	12
Haematopoietic and lymphoid	MEC1	11.8
Haematopoietic and lymphoid	MEC2	12.4
Haematopoietic and lymphoid	MEG01	12.4
Haematopoietic and lymphoid	MHHCALL2	12.2
Haematopoietic and lymphoid	MHHCALL3	12.4
Haematopoietic and lymphoid	MHHCALL4	12.2
Haematopoietic and lymphoid	MINO	12.2
Haematopoietic and lymphoid	MJ	11.9
Haematopoietic and lymphoid	MM1S	11.7
Haematopoietic and lymphoid	MOLM13	12.1
Haematopoietic and lymphoid	MOLM16	13.9
Haematopoietic and lymphoid	MOLM6	12.3
Haematopoietic and lymphoid	MOLP2	11
Haematopoietic and lymphoid	MOLP8	11.2
Haematopoietic and lymphoid	MOLT13	12.5
Haematopoietic and lymphoid	MOLT16	11.9
Haematopoietic and lymphoid	MOLT4	11.8
Haematopoietic and lymphoid	MONOMAC1	12.2
Haematopoietic and lymphoid	MONOMAC6	12.5
Haematopoietic and lymphoid	MOTN1	11.9
Haematopoietic and lymphoid	MUTZ5	12.5
Haematopoietic and lymphoid	MV411	12.4
Haematopoietic and lymphoid	NALM19	12.2
Haematopoietic and lymphoid	NALM1	12.2
Haematopoietic and lymphoid	NALM6	12.6
Haematopoietic and lymphoid	NAMALWA	12.2
Haematopoietic and lymphoid	NB4	13.2
Haematopoietic and lymphoid	NCIH929	11.1
Haematopoietic and lymphoid	NCO2	12.6
Haematopoietic and lymphoid	NOMO1	11.7
Haematopoietic and lymphoid	NUDHL1	11.4
Haematopoietic and lymphoid	NUDUL1	12.2
Haematopoietic and lymphoid	OCIAML2	12.4
Haematopoietic and lymphoid	OCIAML3	11.9
Haematopoietic and lymphoid	OCIAML5	12.6
Haematopoietic and lymphoid	OCILY10	12.4
Haematopoietic and lymphoid	OCILY19	12.3
Haematopoietic and lymphoid	OCILY3	12.2
Haematopoietic and lymphoid	OCIM1	12.8
Haematopoietic and lymphoid	OPM2	11.2
Haematopoietic and lymphoid	P12ICHIKAWA	12.5
Haematopoietic and lymphoid	P31FUJ	12.3
Haematopoietic and lymphoid	P3HR1	13.1
Haematopoietic and lymphoid	PCM6	11.4
Haematopoietic and lymphoid	PEER	12.4
Haematopoietic and lymphoid	PF382	12.7
Haematopoietic and lymphoid	PFEIFFER	12.5
Haematopoietic and lymphoid	PL21	12
Haematopoietic and lymphoid	RAJI	12.9
Haematopoietic and lymphoid	RCHACV	12.3
Haematopoietic and lymphoid	REC1	12.7
Haematopoietic and lymphoid	REH	12.7
Haematopoietic and lymphoid	RI1	12.3
Haematopoietic and lymphoid	RL	12.6
Haematopoietic and lymphoid	RPMI8226	12.1
Haematopoietic and lymphoid	RPMI8402	12.3
Haematopoietic and lymphoid	RS411	12.3
Haematopoietic and lymphoid	SEM	12.3
Haematopoietic and lymphoid	SET2	12.4
Haematopoietic and lymphoid	SIGM5	12.1
Haematopoietic and lymphoid	SKM1	12
Haematopoietic and lymphoid	SKMM2	11.7
Haematopoietic and lymphoid	SR786	11.7
Haematopoietic and lymphoid	ST486	12.4
Haematopoietic and lymphoid	SUDHL10	12.9
Haematopoietic and lymphoid	SUDHL1	12
Haematopoietic and lymphoid	SUDHL4	12.9
Haematopoietic and lymphoid	SUDHL5	13.4
Haematopoietic and lymphoid	SUDHL6	12.8
Haematopoietic and lymphoid	SUDHL8	12.5
Haematopoietic and lymphoid	SUPB15	12.5
Haematopoietic and lymphoid	SUPHD1	11.4
Haematopoietic and lymphoid	SUPM2	11.8
Haematopoietic and lymphoid	SUPT11	12.6
Haematopoietic and lymphoid	SUPT1	12.6
Haematopoietic and lymphoid	TALL1	12.8
Haematopoietic and lymphoid	TF1	12.5
Haematopoietic and lymphoid	THP1	12
Haematopoietic and lymphoid	TO175T	11.3
Haematopoietic and lymphoid	TOLEDO	12.3
Haematopoietic and lymphoid	U266B1	12.6
Haematopoietic and lymphoid	U937	12.2
Haematopoietic and lymphoid	UT7	13
Haematopoietic and lymphoid	WSUDLCL2	13.1
Kidney	769P	11.2
Kidney	786O	11.5
Kidney	A498	10.9
Kidney	A704	10
Kidney	ACHN	11.5
Kidney	BFTC909	11.5
Kidney	CAKI1	10.5
Kidney	CAKI2	10.4
Kidney	CAL54	10.1
Kidney	KMRC1	10.5
Kidney	KMRC20	10.2
Kidney	KMRC2	10.6
Kidney	KMRC3	10.1
Kidney	OSRC2	10.7
Kidney	RCC10RGB	10.4
Kidney	SNU1272	10.6
Kidney	SNU349	9.8
Kidney	TUHR10TKB	10.8
Kidney	TUHR14TKB	10.4
Kidney	TUHR4TKB	10.3
Kidney	VMRCRCW	9.9
Kidney	VMRCRCZ	10.9
Large intestine	C2BBE1	11
Large intestine	CCK81	12.1
Large intestine	CL11	11.7
Large intestine	CL14	11
Large intestine	CL34	11.3
Large intestine	CL40	10.7
Large intestine	COLO205	11.8
Large intestine	COLO320	11.5
Large intestine	COLO678	11.3
Large intestine	CW2	11.9
Large intestine	DLD1	11.9
Large intestine	GP2D	11.9
Large intestine	HCC56	11.1
Large intestine	HCT116	12.1
Large intestine	HCT15	11.8
Large intestine	HS675T	10.6
Large intestine	HS698T	11
Large intestine	HT115	11.8
Large intestine	HT29	10.8
Large intestine	HT55	11.7
Large intestine	KM12	10.7
Large intestine	LOVO	11.2
Large intestine	LS1034	11.5
Large intestine	LS123	11.5
Large intestine	LS180	11.8
Large intestine	LS411N	11.8
Large intestine	LS513	11.5
Large intestine	MDST8	11.7
Large intestine	NCIH508	9.5
Large intestine	NCIH716	11.4
Large intestine	NCIH747	11.7
Large intestine	OUMS23	11
Large intestine	RCM1	10.3
Large intestine	RKO	11.8
Large intestine	SKCO1	11.2
Large intestine	SNU1040	11.6
Large intestine	SNU1197	11.1
Large intestine	SNU175	11.3
Large intestine	SNU283	11.5
Large intestine	SNU407	11.6
Large intestine	SNU503	11
Large intestine	SNU61	11.5
Large intestine	SNU81	10.6
Large intestine	SNUC1	11.6
Large intestine	SNUC2A	11.5
Large intestine	SNUC4	11.6
Large intestine	SNUC5	11.5
Large intestine	SW1116	10.9
Large intestine	SW1417	11.5
Large intestine	SW1463	11.4
Large intestine	SW403	11.2
Large intestine	SW480	11.1
Large intestine	SW48	11.8
Large intestine	SW620	11.9
Large intestine	SW837	10.6
Large intestine	SW948	11.5
Large intestine	T84	11.5
Liver	ALEXANDERCELLS	10.7
Liver	C3A	11.3
Liver	HEP3B217	12
Liver	HEPG2	11
Liver	HLE	11.3
Liver	HLF	11.6
Liver	HUH1	10.9
Liver	HUH6	11.2
Liver	HUH7	11.2
Liver	JHH1	10.6
Liver	JHH2	11.1
Liver	JHH4	11
Liver	JHH5	11.4
Liver	JHH6	11.4
Liver	JHH7	11.6
Liver	LI7	11.5
Liver	PLCPRF5	11.2
Liver	SKHEP1	11.4
Liver	SNU182	10.7
Liver	SNU387	11.1
Liver	SNU398	11.7
Liver	SNU423	12
Liver	SNU449	11.5
Liver	SNU475	11.4
Liver	SNU761	11.6
Liver	SNU878	11
Liver	SNU886	11.2
Lung	A549	11
Lung	ABC1	11.4
Lung	BEN	10.6
Lung	CAL12T	11.3
Lung	CALU1	11.8
Lung	CALU3	10.5
Lung	CALU6	11.7
Lung	CHAGOK1	10.3
Lung	COLO668	12.1
Lung	COLO699	11.9
Lung	CORL105	11.4
Lung	CORL23	11.3
Lung	CORL24	12
Lung	CORL279	12.3
Lung	CORL311	12.2
Lung	CORL47	12
Lung	CORL51	12.2
Lung	CORL88	12.3
Lung	CORL95	12
Lung	CPCN	12.6
Lung	DMS114	11.5
Lung	DMS153	12.4
Lung	DMS273	12.2
Lung	DMS454	11.2
Lung	DMS53	11.6
Lung	DMS79	12.4
Lung	DV90	11.5
Lung	EBC1	12
Lung	EPLC272H	11.9
Lung	HARA	11.8
Lung	HCC1171	11.4
Lung	HCC1195	11.2
Lung	HCC15	11.2
Lung	HCC2279	12
Lung	HCC2935	11.6
Lung	HCC33	11.9
Lung	HCC366	11.3
Lung	HCC4006	11.2
Lung	HCC44	11.3
Lung	HCC78	11.5
Lung	HCC827	12.2
Lung	HCC95	11.2
Lung	HLC1	11.4
Lung	HLFA	11
Lung	HS229T	11.7
Lung	HS618T	11.7
Lung	IALM	11
Lung	KNS62	10.8
Lung	LC1F	11.8
Lung	LC1SQSF	11.6
Lung	LCLC103H	11
Lung	LCLC97TM1	11.1
Lung	LK2	11.6
Lung	LOUNH91	11.1
Lung	LU65	11.7
Lung	LU99	12
Lung	LUDLU1	10.9
Lung	LXF289	11
Lung	MORCPR	11.8
Lung	NCIH1048	11.7
Lung	NCIH1092	12.2
Lung	NCIH1105	12.4
Lung	NCIH1155	12
Lung	NCIH1184	11.9
Lung	NCIH1299	12
Lung	NCIH1339	12.1
Lung	NCIH1341	12.1
Lung	NCIH1355	11.6
Lung	NCIH1373	11.6
Lung	NCIH1385	10.7
Lung	NCIH1395	10.3
Lung	NCIH1435	11.2
Lung	NCIH1436	12.1
Lung	NCIH1437	11.1
Lung	NCIH146	11.5
Lung	NCIH1563	10.3
Lung	NCIH1568	11.2
Lung	NCIH1573	10.6
Lung	NCIH1581	11.7
Lung	NCIH1618	12.5
Lung	NCIH1623	11.3
Lung	NCIH1648	11.2
Lung	NCIH1650	11.7
Lung	NCIH1651	11.4
Lung	NCIH1666	10.5
Lung	NCIH1693	10.9
Lung	NCIH1694	11.7
Lung	NCIH1703	11.8
Lung	NCIH1734	11.8
Lung	NCIH1755	11.3
Lung	NCIH1781	12.2
Lung	NCIH1792	11.4
Lung	NCIH1793	11.6
Lung	NCIH1836	12.7
Lung	NCIH1838	11.7
Lung	NCIH1869	11.7
Lung	NCIH1876	11.9
Lung	NCIH1915	11.8
Lung	NCIH1930	11.7
Lung	NCIH1944	10.1
Lung	NCIH1963	12
Lung	NCIH196	10.5
Lung	NCIH1975	11.6
Lung	NCIH2009	11.2
Lung	NCIH2023	11.3
Lung	NCIH2029	12.4
Lung	NCIH2030	11.9
Lung	NCIH2066	11.9
Lung	NCIH2081	12.1
Lung	NCIH2085	11.6
Lung	NCIH2087	11.8
Lung	NCIH209	11.8
Lung	NCIH2106	11.8
Lung	NCIH2110	11.6
Lung	NCIH211	11.8
Lung	NCIH2122	10.7
Lung	NCIH2126	10.6
Lung	NCIH2141	12.3
Lung	NCIH2170	11.2
Lung	NCIH2171	12.1
Lung	NCIH2172	11.5
Lung	NCIH2196	12.2
Lung	NCIH2227	12
Lung	NCIH2228	11.8
Lung	NCIH226	11.5
Lung	NCIH2286	12.3
Lung	NCIH2291	11.4
Lung	NCIH2342	11.2
Lung	NCIH2347	11.5
Lung	NCIH23	11.9
Lung	NCIH2405	10.6
Lung	NCIH2444	11.1
Lung	NCIH292	10.6
Lung	NCIH322	11.8
Lung	NCIH3255	11.3
Lung	NCIH358	11.3
Lung	NCIH441	11.4
Lung	NCIH446	12.1
Lung	NCIH460	11.4
Lung	NCIH510	12.2
Lung	NCIH520	11.6
Lung	NCIH522	11.6
Lung	NCIH524	12.2
Lung	NCIH526	11.8
Lung	NCIH596	11.4
Lung	NCIH647	11.3
Lung	NCIH650	11.2
Lung	NCIH661	11.4
Lung	NCIH69	12.4
Lung	NCIH727	12.1
Lung	NCIH810	11.4
Lung	NCIH82	12.1
Lung	NCIH838	11.4
Lung	NCIH841	11.8
Lung	NCIH854	11
Lung	NCIH889	12.2
Lung	PC14	10.8
Lung	RERFLCAD1	11.4
Lung	RERFLCAD2	10.6
Lung	RERFLCAI	11.9
Lung	RERFLCKJ	10.9
Lung	RERFLCMS	11.1
Lung	RERFLCSQ1	11
Lung	SBC5	10.8
Lung	SCLC21H	12
Lung	SHP77	12
Lung	SKLU1	12.1
Lung	SKMES1	10.6
Lung	SQ1	11.3
Lung	SW1271	12.6
Lung	SW1573	11.4
Lung	SW900	11.4
Lung	VMRCLCD	11.2
Lung	VMRCLCP	11.8
Oesophagus	COLO680N	10.4
Oesophagus	ECGI10	10.1
Oesophagus	KYSE140	12.2
Oesophagus	KYSE150	11.3
Oesophagus	KYSE180	11.3
Oesophagus	KYSE270	12.1
Oesophagus	KYSE30	10.2
Oesophagus	KYSE410	11.5
Oesophagus	KYSE450	11
Oesophagus	KYSE510	11.3
Oesophagus	KYSE520	11.3
Oesophagus	KYSE70	10.5
Oesophagus	OE19	10.8
Oesophagus	OE33	10.2
Oesophagus	TE10	11.4
Oesophagus	TE11	11.2
Oesophagus	TE14	11.3
Oesophagus	TE15	11.3
Oesophagus	TE1	11.4
Oesophagus	TE4	11.4
Oesophagus	TE5	11.2
Oesophagus	TE6	12.1
Oesophagus	TE8	11.7
Oesophagus	TE9	11.2
Oesophagus	TT	10.7
Ovary	59M	10.7
Ovary	A2780	11.8
Ovary	CAOV3	11.5
Ovary	CAOV4	10.7
Ovary	COLO704	12.4
Ovary	COV318	11.5
Ovary	COV362	11.2
Ovary	COV434	11.3
Ovary	COV504	12
Ovary	COV644	10.7
Ovary	EFO21	11
Ovary	EFO27	11
Ovary	ES2	11.7
Ovary	FUOV1	11.1
Ovary	HEYA8	11.1
Ovary	HS571T	10
Ovary	IGROV1	11.2
Ovary	JHOC5	12.1
Ovary	JHOM1	10.5
Ovary	JHOM2B	11.5
Ovary	JHOS2	11.4
Ovary	JHOS4	11
Ovary	KURAMOCHI	10.1
Ovary	MCAS	11.1
Ovary	NIHOVCAR3	11
Ovary	OAW28	11.9
Ovary	OAW42	11.8
Ovary	OC314	11.7
Ovary	OC316	11.9
Ovary	ONCODG1	11.4
Ovary	OV56	10.7
Ovary	OV7	12.1
Ovary	OV90	10.1
Ovary	OVCAR4	11.7
Ovary	OVCAR8	12.4
Ovary	OVISE	11.3
Ovary	OVK18	11.9
Ovary	OVKATE	10.7
Ovary	OVMANA	11
Ovary	OVSAHO	12
Ovary	OVTOKO	11.6
Ovary	RMGI	10.4
Ovary	RMUGS	11.4
Ovary	SKOV3	11.3
Ovary	SNU119	11.9
Ovary	SNU840	11
Ovary	SNU8	10.9
Ovary	TOV112D	11.9
Ovary	TOV21G	11.3
Ovary	TYKNU	11.8
Pancreas	ASPC1	9.5
Pancreas	BXPC3	10.9
Pancreas	CAPAN1	10.7
Pancreas	CAPAN2	11.1
Pancreas	CFPAC1	10.3
Pancreas	DANG	11.8
Pancreas	HPAC	10.5
Pancreas	HPAFII	10.8
Pancreas	HS766T	11.1
Pancreas	HUPT3	12.2
Pancreas	HUPT4	10.7
Pancreas	KCIMOH1	10.3
Pancreas	KLM1	11.1
Pancreas	KP2	10.8
Pancreas	KP3	10.5
Pancreas	KP4	11.9
Pancreas	L33	11.4
Pancreas	MIAPACA2	11.9
Pancreas	PANC0203	11.6
Pancreas	PANC0213	11
Pancreas	PANC0327	11.5
Pancreas	PANC0403	10.9
Pancreas	PANC0504	11.5
Pancreas	PANC0813	11.3
Pancreas	PANC1005	12.1
Pancreas	PANC1	11.8
Pancreas	PATU8902	11.7
Pancreas	PATU8988S	11.1
Pancreas	PATU8988T	11.4
Pancreas	PK1	11.4
Pancreas	PK45H	11
Pancreas	PK59	11.6
Pancreas	PL45	12.2
Pancreas	PSN1	11.4
Pancreas	QGP1	11.1
Pancreas	SNU213	10.7
Pancreas	SNU324	11.4
Pancreas	SNU410	11.5
Pancreas	SU8686	9.6
Pancreas	SUIT2	11.7
Pancreas	SW1990	11.5
Pancreas	T3M4	11.2
Pancreas	TCCPAN2	11.1
Pancreas	YAPC	11.4
Pleura	ACCMESO1	10.3
Pleura	DM3	10.2
Pleura	ISTMES1	11.8
Pleura	ISTMES2	11.7
Pleura	JL1	11.1
Pleura	MPP89	11.3
Pleura	MSTO211H	11.8
Pleura	NCIH2052	11
Pleura	NCIH2452	11.7
Pleura	NCIH28	11.5
Prostate	22RV1	11.8
Prostate	DU145	11.9
Prostate	LNCAPCLONEFGC	10.9
Prostate	MDAPCA2B	11
Prostate	NCIH660	12.4
Prostate	PC3	11.6
Prostate	VCAP	10.5
Salivary gland	A253	11.7
Salivary gland	YD15	12
Skin	A101D	12
Skin	A2058	10.9
Skin	A375	11.9
Skin	C32	11.4
Skin	CHL1	11.7
Skin	CJM	9.5
Skin	COLO679	11.4
Skin	COLO741	11.5
Skin	COLO783	11.4
Skin	COLO792	11.2
Skin	COLO800	11.3
Skin	COLO818	11.4
Skin	COLO829	10.9
Skin	COLO849	11.6
Skin	G361	11.1
Skin	GRM	11.9
Skin	HMCB	11.7
Skin	HS294T	11.6
Skin	HS600T	10.9
Skin	HS688AT	10.5
Skin	HS695T	11.3
Skin	HS839T	11.6
Skin	HS852T	12.1
Skin	HS895T	10.5
Skin	HS934T	11.5
Skin	HS936T	11.8
Skin	HS939T	12
Skin	HS940T	10.7
Skin	HS944T	11.5
Skin	HT144	12
Skin	IGR1	11.7
Skin	IGR37	11.3
Skin	IGR39	12
Skin	IPC298	11.9
Skin	K029AX	11.5
Skin	LOXIMVI	11.1
Skin	MALME3M	10.7
Skin	MDAMB435S	11.3
Skin	MELHO	11.4
Skin	MELJUSO	11.6
Skin	MEWO	12.2
Skin	RPMI7951	11.9
Skin	RVH421	11.7
Skin	SH4	11.4
Skin	SKMEL1	11.8
Skin	SKMEL24	11.1
Skin	SKMEL28	11.3
Skin	SKMEL2	11.7
Skin	SKMEL30	11.7
Skin	SKMEL31	11.3
Skin	SKMEL3	10.7
Skin	SKMEL5	11.2
Skin	UACC257	11.7
Skin	UACC62	11.9
Skin	WM115	11.7
Skin	WM1799	11.6
Skin	WM2664	11.6
Skin	WM793	11.7
Skin	WM88	11.5
Skin	WM983B	11.6
Small intestine	HUTU80	12
Soft tissue	A204	11.5
Soft tissue	G401	11.9
Soft tissue	G402	11.5
Soft tissue	GCT	12.1
Soft tissue	HS729	12.2
Soft tissue	HT1080	11.9
Soft tissue	KYM1	11.6
Soft tissue	MESSA	11.3
Soft tissue	RD	12.4
Soft tissue	RH30	11.8
Soft tissue	RH41	11.4
Soft tissue	RKN	11.7
Soft tissue	S117	11.8
Soft tissue	SJRH30	11.6
Soft tissue	SKLMS1	11.5
Soft tissue	SKUT1	12.5
Soft tissue	TE125T	10
Soft tissue	TE159T	10.9
Soft tissue	TE441T	11.7
Soft tissue	TE617T	11.7
Stomach	2313287	10.9
Stomach	AGS	11.2
Stomach	AZ521	12
Stomach	ECC10	12.3
Stomach	ECC12	11.9
Stomach	FU97	10.3
Stomach	GCIY	11
Stomach	GSS	10.8
Stomach	GSU	11
Stomach	HGC27	12.9
Stomach	HS746T	12
Stomach	HUG1N	11.1
Stomach	IM95	11.2
Stomach	KATOIII	10.7
Stomach	KE39	11.2
Stomach	LMSU	12
Stomach	MKN1	11.8
Stomach	MKN45	12.1
Stomach	MKN74	10
Stomach	MKN7	11.3
Stomach	NCCSTCK140	9.9
Stomach	NCIN87	11.8
Stomach	NUGC2	11.5
Stomach	NUGC3	11.5
Stomach	NUGC4	10.7
Stomach	OCUM1	11.1
Stomach	RERFGC1B	11.7
Stomach	SH10TC	11.1
Stomach	SNU16	11.8
Stomach	SNU1	11.5
Stomach	SNU216	11.1
Stomach	SNU520	11.3
Stomach	SNU5	11.7
Stomach	SNU601	11.4
Stomach	SNU620	11.4
Stomach	SNU668	11.4
Stomach	SNU719	10.8
Stomach	TGBC11TKB	11
Thyroid	8305C	11.4
Thyroid	8505C	11.6
Thyroid	BCPAP	10.4
Thyroid	BHT101	10.6
Thyroid	CAL62	11.9
Thyroid	CGTHW1	11.6
Thyroid	FTC133	12.2
Thyroid	FTC238	12
Thyroid	ML1	10.3
Thyroid	SW579	11.9
Thyroid	TT2609C02	11.7
Thyroid	TT	11.3
Upper aerodigestive tract	BHY	11.2
Upper aerodigestive tract	BICR16	10.7
Upper aerodigestive tract	BICR18	11.2
Upper aerodigestive tract	BICR22	9.8
Upper aerodigestive tract	BICR31	10.4
Upper aerodigestive tract	BICR56	9.3
Upper aerodigestive tract	BICR6	10.7
Upper aerodigestive tract	CAL27	11.2
Upper aerodigestive tract	CAL33	10.3
Upper aerodigestive tract	DETROIT562	11.5
Upper aerodigestive tract	FADU	11.5
Upper aerodigestive tract	HS840T	11.4
Upper aerodigestive tract	HSC2	10.9
Upper aerodigestive tract	HSC3	12.3
Upper aerodigestive tract	HSC4	10.8
Upper aerodigestive tract	PECAPJ15	11.4
Upper aerodigestive tract	PECAPJ34CLONEC12	11.6
Upper aerodigestive tract	PECAPJ41CLONED2	10.9
Upper aerodigestive tract	PECAPJ49	11.2
Upper aerodigestive tract	SCC15	10.6
Upper aerodigestive tract	SCC25	11.5
Upper aerodigestive tract	SCC4	11.1
Upper aerodigestive tract	SCC9	10.6
Upper aerodigestive tract	SNU1076	9.4
Upper aerodigestive tract	SNU1214	11.9
Upper aerodigestive tract	SNU46	12
Upper aerodigestive tract	SNU899	10.7
Upper aerodigestive tract	YD10B	10.9
Upper aerodigestive tract	YD38	11.5
Upper aerodigestive tract	YD8	10.8
Urinary tract	5637	11.8
Urinary tract	639V	12.1
Urinary tract	647V	11.4
Urinary tract	BC3C	11.6
Urinary tract	BFTC905	11.8
Urinary tract	CAL29	10.9
Urinary tract	HS172T	9.9
Urinary tract	HT1197	11.1
Urinary tract	HT1376	11.5
Urinary tract	J82	11.4
Urinary tract	JMSU1	12.6
Urinary tract	KMBC2	11.4
Urinary tract	KU1919	11.7
Urinary tract	RT11284	11.6
Urinary tract	RT112	11.3
Urinary tract	RT4	11.7
Urinary tract	SCABER	11.2
Urinary tract	SW1710	11
Urinary tract	SW780	11
Urinary tract	T24	11.7
Urinary tract	TCCSUP	10.5
Urinary tract	UMUC1	10.5
Urinary tract	UMUC3	11.5
Urinary tract	VMCUB1	11.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	9.5
Adrenal gland	6.9
Appendix	29
Bone marrow	27.6
Breast	10.5
Cerebral cortex	16.8
Cervix, uterine	14.1
Colon	9.5
Duodenum	8.8
Endometrium	13.4
Epididymis	5.9
Esophagus	9.3
Fallopian tube	11.6
Gallbladder	12.7
Heart muscle	4.3
Kidney	4.7
Liver	2.6
Lung	14.3
Lymph node	44.2
Ovary	7.2
Pancreas	1.3
Parathyroid gland	16.7
Placenta	51.2
Prostate	9.5
Rectum	13
Salivary gland	3
Seminal vesicle	8.9
Skeletal muscle	2.7
Skin	15.7
Small intestine	11.6
Smooth muscle	17.4
Spleen	16.7
Stomach	9
Testis	36.9
Thyroid gland	12.3
Tonsil	31.4
Urinary bladder	12.9

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27666771	Overexpression	Colorectal Carcinoma	Significant upregulation of DNMT1, DNMT3A, and DNMT3B expression was found in para-carcinoma tissues, compared with the histopathologically unchanged tissues (P<0.05)
28652820	Overexpression	Colon Carcinoma	The expression of DNMT1 was significantly higher in CC cells compared to that in the normal cervical epithelium.
26966018	Overexpression	Oesophagal Squamous Cell Carcinoma	DNMT1 overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression.
27658300	Overexpression	Cervical Carcinoma	Therefore, we infer that miR-375 is downregulated partly due to promoter hypermethylation mediated by DNMT1 in HPV-16 positive cervical cancer cells.
27543768	Overexpression	Medulloblastoma	In conclusion, DNMT1, DNMT3A and DNMT3B are highly expressed in human medulloblastoma samples, suggesting that promoter hypermethylation may play a role in medulloblastoma development.
27261509	Overexpression	Pancreatic Carcinoma	Mechanistically, CSC expressed higher DNMT1 levels than non-CSC.
27259275	Overexpression	Acute Myeloid Leukemia	In support of these results, we demonstrate that combining GO-203 with the DNMT1 inhibitor decitabine is highly effective in reducing DNMT1 levels and decreasing AML cell survival.
27071379	Overexpression	Breast Carcinoma	High tumor expression of DNMT1 was associated with shorter OS in univariate analysis (p = 0.041).
26998112	Overexpression	Breast Carcinoma	The results of the present study revealed that DNMT1 protein and mRNA levels were low in normal breast specimens (10.00 and 46.05%, respectively) and ERα-positive breast cancer specimens (15.00 and 48.68%, respectively), compared with increased levels in ERα-negative breast cancer specimens (81.11 and 88.89%, respectively; P<0.05).
26966018	Overexpression	Oral Cavity Squamous Cell Carcinoma	DNMT1, DNMT3A, and DNMT3B were overexpressed in 36.9, 26, and 23% of the OSCC patients, respectively. DNMT1 overexpression was significantly associated with the overall survival, p=0.029, and relapse-free survival of OSCC patients, p=0.003.
26708868	Overexpression	Chronic myeloid leukemia	The expression of DNMT mRNA increases in advanced CML as compared with normal controls and CML-CP, and the increased levels of DNMT mRNA probably correlate with disease progression in CML.
26261487	Overexpression	Astrocytic tumour	Our data showed that DNMT1 was highly expressed in high grade astrocytic tumours.
25950085	Overexpression	Pancreatic Carcinoma	We discovered the expression level of miR-148a significantly decreased in pancreatic cancer tissues whereas that of DNMT1 increased.
25886188	Overexpression	Esophageal Squamous Cell Carcinoma	DNMT1 proteins are highly expressed in cancer tissues
25746661	Overexpression	Burkitt Lymphoma	Here, we demonstrated for the first time the overexpression of DNMT1 and DNMT3B in Burkitt lymphoma (BL) tumor samples (69% and 86%, respectively).
25738352	Overexpression	Prostate Carcinoma	Due to the high expression of DNMT1 mRNA, it is likely that the hypermethylation of CpG islands contributed to the silencing of GSTP1 and APC in PCa tissues.
25461380	Overexpression	Gastric Carcinoma	We found that DNMT1 and 3b were up-regulated in gastric cancer and were detected in 51.1% and 57.4% of cases, respectively.
25349215	Overexpression	Urological cancer	DNMT1 abundance has been frequently seen in urogenital system tumors.
25232208	Overexpression	Clear Cell Renal Cell Carcinoma	We found DNMT1 protein was significantly higher expressed in ccRCC than that of in no-tumor tissues (56.2% and 27.3%, respectively, P=0.018).
24762689	Overexpression	Non-Small Cell Lung Carcinoma	The protein expressions of HDAC1 and DNMT1 in patients with lung cancer (145 ± 53, 50 ± 11) were higher than those in control group (78 ± 56, 27 ± 6).
24649186	Overexpression (Copy number gain)	Endometrial Carcinoma	In conclusion, overexpression of DNMT1 protein is caused by various factors, one of which is gene amplification.
24548441	Overexpression	Lung Carcinoma	The protein expressions of DNMT1, DNMT3a and DNMT3b in patients with lung cancer (15 ± 10, 997 ± 76 , 302 ± 25) were higher than those of the controls (13 ± 10, 344 ± 93, 108 ± 22).
24423239	Overexpression	Pancreatic Carcinoma	DNMT1, 3a and 3b proteins were expressed in 46.6%, 23.9%, and 77.3% of PDAC tissues, respectively, but were not expressed in normal pancreatic tissues.
23420051	Overexpression	Ovarian Carcinoma	The results indicated that the mRNA expression of DNMT1, DNMT3b and class I HDACs was increased in ovarian cancers, while the expression of DNMT3a was not different between cancer tissues and normal ovaries.
23408490	Overexpression	Gastric Carcinoma	In the present study we demonstrated that the expression levels of CDX2 and DNA methyltransferase enzyme 1 (DNMT1) mRNA were significantly higher in GC compared with distal non-cancerous tissue.
22901195	Overexpression	Esophageal Squamous Cell Carcinoma	We found that DNMT1 was overexpressed in ESCC tissues compared with paired non-cancerous tissues, the overexpression being correlated with smoking status and low expression of RARβ.
17657744	Overexpression	Colorectal Carcinoma	The mRNA levels of SUV39H1 and DNMT1 were elevated in 25% and 42% of 219 colorectal cancers, respectively.

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.246	5.73e-07	29.2	51.5	19.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.425	2.44e-48	21.1	59.8	19.1	Neutral
CESC	Cervical and endocervical cancers	292	0.503	3.7e-20	26.7	59.2	14	Neutral
COAD	Colon adenocarcinoma	449	0.251	7.21e-08	9.8	74.2	16	Neutral
ESCA	Esophageal carcinoma	183	0.428	1.48e-09	43.2	42.6	14.2	Loss
GBM	Glioblastoma multiforme	147	0.353	1.15e-05	8.2	56.5	35.4	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.374	1.54e-18	23	65.8	11.3	Neutral
KIRC	Kidney renal clear cell carcinoma	525	-0.036	0.406	2.7	88.4	9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.104	0.0771	6.2	91.7	2.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.167	0.0314	1.8	95.2	3	Neutral
LGG	Brain Lower Grade Glioma	513	0.278	1.42e-10	3.1	73.5	23.4	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.086	0.101	22.3	62.6	15.1	Neutral
LUAD	Lung adenocarcinoma	512	0.358	6.04e-17	51.8	43.4	4.9	Loss
LUSC	Lung squamous cell carcinoma	498	0.45	3e-26	39	41.6	19.5	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.659	8.6e-39	34.3	25.7	40	Gain
PAAD	Pancreatic adenocarcinoma	177	0.23	0.00203	14.7	76.8	8.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.421	2.49e-08	0.6	85.8	13.6	Neutral
PRAD	Prostate adenocarcinoma	491	0.112	0.0127	5.3	92.7	2	Neutral
READ	Rectum adenocarcinoma	164	0.23	0.00308	17.7	62.8	19.5	Neutral
SARC	Sarcoma	255	0.492	5.92e-17	10.6	46.7	42.7	Gain
SKCM	Skin Cutaneous Melanoma	367	0.346	9.07e-12	22.3	61	16.6	Neutral
STAD	Stomach adenocarcinoma	413	0.353	1.34e-13	31.2	58.8	9.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.057	0.486	31.3	43.3	25.3	Neutral
THCA	Thyroid carcinoma	497	0.185	3.41e-05	1.4	97.2	1.4	Neutral
THYM	Thymoma	119	-0.009	0.926	3.4	94.1	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.386	1.7e-20	13.6	72.3	14.2	Neutral

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.069	0.158	17	408	-0.022	0.000921	NS/NA
BRCA	Breast invasive carcinoma	-0.344	0	83	785	-0.037	3.92e-09	NS/NA
CESC	Cervical and endocervical cancers	-0.108	0.059	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.161	0.00412	19	297	-0.004	0.119	NS/NA
ESCA	Esophageal carcinoma	-0.106	0.143	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.27	0.0302	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	0.006	0.89	20	522	-0.006	0.048	NS/NA
KIRC	Kidney renal clear cell carcinoma	0.01	0.856	24	319	0.001	0.0487	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.15	0.0094	23	275	0	0.486	NS/NA
LAML	Acute Myeloid Leukemia	-0.183	0.0171	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.083	0.0557	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.12	0.0145	41	373	-0.02	1.98e-12	NS/NA
LUAD	Lung adenocarcinoma	-0.087	0.058	21	456	-0.017	3.45e-05	NS/NA
LUSC	Lung squamous cell carcinoma	-0.023	0.655	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.85	0.00607	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.147	0.0469	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.115	0.116	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.033	0.442	35	498	-0.001	0.478	NS/NA
READ	Rectum adenocarcinoma	-0.078	0.437	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.142	0.0212	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.079	0.0883	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.217	2.46e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.139	0.0834	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.126	0.00289	50	509	-0.001	0.0204	NS/NA
THYM	Thymoma	-0.093	0.309	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	0.018	0.697	34	431	-0.031	1.02e-06	NS/NA

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	2	Medium
Bone marrow	3	High
Breast	0	Not detected
Bronchus	1	Low
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	0	Not detected
Colon	1	Low
Duodenum	1	Low
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	1	Low
Fallopian tube	0	Not detected
Gallbladder	0	Not detected
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	0	Not detected
Liver	0	Not detected
Lung	0	Not detected
Lymph node	3	High
Nasopharynx	1	Low
Oral mucosa	1	Low
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	3	High
Prostate	0	Not detected
Rectum	1	Low
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	1	Low
Small intestine	1	Low
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	1	Low
Testis	3	High
Thyroid gland	0	Not detected
Tonsil	3	High
Urinary bladder	0	Not detected
Vagina	1	Low

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.239	NS	24476821
BRCA	Breast invasive carcinoma	521	2.86e-27	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0741	NS	22810696
GBM	Glioblastoma multiforme	157	3.58e-05	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.00613	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00909	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.000394	Significant	26824661
LUAD	Lung adenocarcinoma	230	4.8e-06	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0354	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00698	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.04	Significant	26544944
READ	Rectum adenocarcinoma	67	0.537	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.197	NS	26091043
STAD	Stomach adenocarcinoma	277	8.34e-11	Significant	25079317
THCA	Thyroid carcinoma	391	2.48e-25	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000278	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.192	0.421	NS
BRCA	Breast invasive carcinoma	1079	1.037	0.871	NS
CESC	Cervical and endocervical cancers	291	0.62	0.172	NS
COAD	Colon adenocarcinoma	439	0.657	0.121	NS
ESCA	Esophageal carcinoma	184	0.829	0.593	NS
GBM	Glioblastoma multiforme	158	0.919	0.737	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.657	0.033	Longer
KIRC	Kidney renal clear cell carcinoma	531	1.367	0.137	NS
KIRP	Kidney renal papillary cell carcinoma	287	4.134	0.00232	Shorter
LAML	Acute Myeloid Leukemia	149	2.019	0.0172	Shorter
LGG	Brain Lower Grade Glioma	511	2.135	0.0026	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.754	0.0197	Shorter
LUAD	Lung adenocarcinoma	502	1.073	0.734	NS
LUSC	Lung squamous cell carcinoma	494	0.739	0.111	NS
OV	Ovarian serous cystadenocarcinoma	303	0.73	0.137	NS
PAAD	Pancreatic adenocarcinoma	177	1.158	0.616	NS
PCPG	Pheochromocytoma and Paraganglioma	179	615134789.409	0.0784	NS
PRAD	Prostate adenocarcinoma	497	5.083	0.129	NS
READ	Rectum adenocarcinoma	159	0.429	0.196	NS
SARC	Sarcoma	259	1.519	0.143	NS
SKCM	Skin Cutaneous Melanoma	459	1.46	0.0358	Shorter
STAD	Stomach adenocarcinoma	388	0.573	0.0122	Longer
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.49	0.303	NS
THYM	Thymoma	119	0	0.0264	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.135	0.679	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.005	0.913	NS
BRCA	Breast invasive carcinoma	1071	0.01	0.74	NS
CESC	Cervical and endocervical cancers	167	0.085	0.273	NS
COAD	Colon adenocarcinoma	445	-0.073	0.122	NS
ESCA	Esophageal carcinoma	162	-0.075	0.344	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.063	0.181	NS
KIRC	Kidney renal clear cell carcinoma	531	0.056	0.195	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.236	0.00012	Higher
LIHC	Liver hepatocellular carcinoma	347	0.092	0.0885	NS
LUAD	Lung adenocarcinoma	507	0.048	0.282	NS
LUSC	Lung squamous cell carcinoma	497	0.071	0.114	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.079	0.169	NS
PAAD	Pancreatic adenocarcinoma	176	-0.076	0.317	NS
READ	Rectum adenocarcinoma	156	-0.085	0.292	NS
SKCM	Skin Cutaneous Melanoma	410	-0.128	0.00973	Lower
STAD	Stomach adenocarcinoma	392	-0.065	0.196	NS
TGCT	Testicular Germ Cell Tumors	81	0.308	0.00508	Higher
THCA	Thyroid carcinoma	499	-0.011	0.811	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.009	0.835	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.026	0.664	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.211	2.11e-06	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.107	0.0145	Higher
LGG	Brain Lower Grade Glioma	514	0.299	4.64e-12	Higher
LIHC	Liver hepatocellular carcinoma	366	0.216	2.97e-05	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.038	0.515	NS
PAAD	Pancreatic adenocarcinoma	176	0.105	0.164	NS
STAD	Stomach adenocarcinoma	406	-0.053	0.289	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.17	7.68e-05	Higher

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB00928	Azacitidine	Small Molecule Drug
DB01035	Procainamide	Small Molecule Drug
DB01099	Flucytosine	Small Molecule Drug
DB01262	Decitabine	Small Molecule Drug

Summary
Symbol	DNMT1
Name	DNA methyltransferase 1
Aliases	MCMT; CXXC9; DNMT; ADCADN; HSN1E; CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA methyltransferase Hsa ......
Location	19p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27658300	Cervical Carcinoma	downstream	miR-375	Negative regulation	Therefore, we infer that miR-375 is downregulated partly due to promoter hypermethylation mediated by DNMT1 in HPV-16 positive cervical cancer cells.
27651312	Gastric Carcinoma	partner	PRC2; LSD1; HOXA11-AS	binding	LncRNA HOXA11-AS promotes proliferation and invasion of gastric cancer by scaffolding the chromatin modification factors PRC2, LSD1 and DNMT1.
27261509	Pancreatic Carcinoma	downstream	miR-17-92 Cluster	Negative regulation	DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster.
27259275	Acute Myeloid Leukemia	upstream	MUC1-C	Positive regulation	The mechanistic basis for this relationship is supported by the demonstration that MUC1-C activates the NF-κB p65 pathway, promotes occupancy of the MUC1-C/NF-κB complex on the DNMT1 promoter and drives DNMT1 transcription.
27212035	Breast Carcinoma	upstream	MUC1-C	Positive regulation	Our results demonstrate that MUC1-C induces the expression of DNMT1 and DNMT3b, but not DNMT3a, in breast and other carcinoma cell types.
27022290	Breast Carcinoma	upstream	TP53	Negative regulation	In conclusion, the data from this preliminary study have shown that p53 inhibits the methylation of p125 gene promoter by downregulating the activities of Sp1 and DNMT1 in breast cancer.
27022290	Breast Carcinoma	downstream	p125	Positive regulation	In conclusion, the data from this preliminary study have shown that p53 inhibits the methylation of p125 gene promoter by downregulating the activities of Sp1 and DNMT1 in breast cancer.
26998112	Breast Carcinoma	downstream	ERα	Negative regulation	DNMT1 expression was positively correlated with methylation of ERα (P<0.05), and was positively correlated with the methylation of CpG islands of ERα, indicating that the detection of DNMT1 expression may be significant for the diagnosis and typing of breast cancer.
26676363	Glioma	downstream	MEG3	Negative regulation	These results suggest that DNMT1-mediated MEG3 hypermethylation caused the loss of MEG3 expression, followed by the inhibition of the p53 pathways in gliomas.
26261487	Astrocytic tumour	partner	MGMT	negtive correlation	DNMT1 overexpression was seen correlated with a reduction of MGMT protein expression in high grade astrocytic tumour.
25950085	Pancreatic Carcinoma	upstream	miR-148a	Negative regulation	In ASPC-1 cancer cells, the overexpression of miR-148a led to a decreased level of DNMT1 and reduced the proliferation and metastasis of ASPC-1 cells.
25927928	Non-Small Cell Lung Carcinoma	upstream	miR-148b	Negative regulation	miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNMT1 expression.
25886188	Esophageal Squamous Cell Carcinoma	downstream	RASSF1A	Negative regulation	Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
25738352	Prostate Carcinoma	downstream	GSTP1; APC	negative regulation	Due to the high expression of DNMT1 mRNA, it is likely that the hypermethylation of CpG islands contributed to the silencing of GSTP1 and APC in PCa tissues.
25595591	Gastric Carcinoma; Glioblastoma	downstream	microRNA-200b/a/429	Negative regulation	Collectively, these results indicated that EZH2 and DNMT1-mediated epigenetic silencing contributed to the progression of gastric cancer and glioblastoma, and therefore represents a novel therapeutic target for malignant tumors.
25349215	Urological cancer	upstream	β-catenin	Positive regulation	mRNA levels of β-catenin increased after treatment with SB216273 and protein levels of pGSK3β(Ser9), β-catenin, and DNMT1 increased in comparison to control.
24911372	Hepatocellular Carcinoma	upstream	miR-185	Negative regulation	miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway.
24247422	Hepatocellular Carcinoma	upstream	HBx	Positive regulation	Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expression independent of DNA methylation.
24247422	Hepatocellular Carcinoma	downstream	RASSF1A	Negative regulation	Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expression independent of DNA methylation.
23918933	Nijmegen breakage syndrome	upstream	NBS1		These results suggest that DNMT1 function in the regulatory response is controlled by NBS1.
23408490	Gastric Carcinoma	partner	CDX2	negtive correlation	The expression of CDX2 mRNA was inversely correlated with that of DNMT1 mRNA in GC.