CR2Cancer

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF08123 Histone methylation protein DOT1

Function

Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone methylation	H3K79	#	12123582

> Gene Ontology [ TOP ]
Biological Process	GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0006342 chromatin silencing GO:0006348 chromatin silencing at telomere GO:0006479 protein methylation GO:0007259 JAK-STAT cascade GO:0008213 protein alkylation GO:0016458 gene silencing GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0031570 DNA integrity checkpoint GO:0032200 telomere organization GO:0032259 methylation GO:0034729 histone H3-K79 methylation GO:0034968 histone lysine methylation GO:0040029 regulation of gene expression, epigenetic GO:0043414 macromolecule methylation GO:0045814 negative regulation of gene expression, epigenetic GO:0046425 regulation of JAK-STAT cascade GO:0051098 regulation of binding GO:0051101 regulation of DNA binding GO:0097696 STAT cascade GO:1904892 regulation of STAT cascade GO:2000677 regulation of transcription regulatory region DNA binding
Molecular Function	GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0031151 histone methyltransferase activity (H3-K79 specific) GO:0042054 histone methyltransferase activity
Cellular Component	GO:0000781 chromosome, telomeric region GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00310 Lysine degradation
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214841: PKMTs methylate histone lysines

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3680842	c.200+10G>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM1611925	c.188A>G	p.Y63C	Substitution - Missense	Liver
COSM993747	c.1536G>T	p.Q512H	Substitution - Missense	Endometrium
COSM1304321	c.2931C>T	p.T977T	Substitution - coding silent	Urinary_tract
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM6004028	c.2001C>T	p.D667D	Substitution - coding silent	Prostate
COSM710860	c.399C>G	p.P133P	Substitution - coding silent	Lung
COSM26569	c.3155G>T	p.G1052V	Substitution - Missense	Lung
COSM4476745	c.2091C>T	p.T697T	Substitution - coding silent	Skin
COSM5017233	c.731C>T	p.A244V	Substitution - Missense	Kidney
COSM417658	c.2128G>A	p.E710K	Substitution - Missense	Urinary_tract
COSM4076234	c.1372A>G	p.S458G	Substitution - Missense	Stomach
COSM5612665	c.2680G>A	p.A894T	Substitution - Missense	Adrenal_gland
COSM5573647	c.5198C>T	p.S1733L	Substitution - Missense	Prostate
COSM1304319	c.2710G>A	p.V904M	Substitution - Missense	Urinary_tract
COSM5773636	c.1183C>T	p.R395C	Substitution - Missense	Breast
COSM3371238	c.3161G>A	p.G1054D	Substitution - Missense	Thyroid
COSM1716187	c.1773G>A	p.A591A	Substitution - coding silent	Central_nervous_system
COSM3680840	c.200+1G>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4991283	c.2306C>T	p.P769L	Substitution - Missense	Skin
COSM2747745	c.4509C>T	p.A1503A	Substitution - coding silent	Large_intestine
COSM5679565	c.3359C>A	p.P1120H	Substitution - Missense	Soft_tissue
COSM3680848	c.4484A>G	p.Q1495R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4921068	c.2469G>T	p.M823I	Substitution - Missense	Liver
COSM5583461	c.365C>T	p.P122L	Substitution - Missense	Skin
COSM417666	c.1251G>A	p.M417I	Substitution - Missense	Urinary_tract
COSM5606486	c.3889C>T	p.P1297S	Substitution - Missense	Skin
COSM4432189	c.3902C>T	p.S1301L	Substitution - Missense	Oesophagus
COSM5812061	c.1738G>T	p.E580*	Substitution - Nonsense	Liver
COSM3748049	c.2349G>A	p.R783R	Substitution - coding silent	Central_nervous_system
COSM4991287	c.2709C>T	p.P903P	Substitution - coding silent	Skin
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM439083	c.736G>A	p.G246S	Substitution - Missense	Breast
COSM5365718	c.1227C>A	p.R409R	Substitution - coding silent	Large_intestine
COSM2747819	c.5190G>A	p.A1730A	Substitution - coding silent	Large_intestine
COSM5056464	c.2489C>T	p.P830L	Substitution - Missense	Stomach
COSM4991289	c.3005C>T	p.P1002L	Substitution - Missense	Skin
COSM417665	c.1617G>A	p.Q539Q	Substitution - coding silent	Urinary_tract
COSM3892121	c.2502C>T	p.S834S	Substitution - coding silent	Skin
COSM3103060	c.140A>T	p.E47V	Substitution - Missense	Large_intestine
COSM1392050	c.3102C>A	p.F1034L	Substitution - Missense	Large_intestine
COSM1611966	c.2744A>G	p.E915G	Substitution - Missense	Liver
COSM5364993	c.242C>T	p.A81V	Substitution - Missense	Large_intestine
COSM5573647	c.5198C>T	p.S1733L	Substitution - Missense	Prostate
COSM399792	c.2515C>T	p.Q839*	Substitution - Nonsense	Lung
COSM5606486	c.3889C>T	p.P1297S	Substitution - Missense	Skin
COSM1611971	c.4849G>A	p.V1617I	Substitution - Missense	Liver
COSM2747627	c.2721C>T	p.P907P	Substitution - coding silent	Skin
COSM5449225	c.2941C>T	p.R981C	Substitution - Missense	Large_intestine
COSM3796883	c.3018C>G	p.L1006L	Substitution - coding silent	Urinary_tract
COSM4076230	c.769T>C	p.F257L	Substitution - Missense	Stomach
COSM4131555	c.4779T>C	p.P1593P	Substitution - coding silent	Thyroid
COSM4991285	c.2708C>T	p.P903L	Substitution - Missense	Skin
COSM4995863	c.1361G>C	p.R454T	Substitution - Missense	Upper_aerodigestive_tract
COSM4416984	c.3391-5C>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM4471375	c.1715C>T	p.S572F	Substitution - Missense	Skin
COSM6017115	c.1680C>T	p.T560T	Substitution - coding silent	Skin
COSM5509551	c.978T>A	p.F326L	Substitution - Missense	Biliary_tract
COSM4928129	c.1828G>T	p.D610Y	Substitution - Missense	Liver
COSM5614630	c.964-1G>C	p.?	Unknown	Lung
COSM4953289	c.2345G>T	p.R782M	Substitution - Missense	Liver
COSM4827372	c.4227G>T	p.K1409N	Substitution - Missense	Cervix
COSM4131556	c.4849G>C	p.V1617L	Substitution - Missense	Thyroid
COSM5661530	c.2558G>T	p.R853L	Substitution - Missense	Soft_tissue
COSM993839	c.3645G>A	p.P1215P	Substitution - coding silent	Endometrium
COSM1733884	c.3337G>A	p.V1113I	Substitution - Missense	Pancreas
COSM474434	c.687G>A	p.R229R	Substitution - coding silent	Kidney
COSM3770620	c.2839G>A	p.G947R	Substitution - Missense	Soft_tissue
COSM2747810	c.4972delC	p.T1660fs*>79	Deletion - Frameshift	Prostate
COSM417668	c.1129G>T	p.E377*	Substitution - Nonsense	Urinary_tract
COSM1204461	c.1648A>C	p.K550Q	Substitution - Missense	Large_intestine
COSM4617914	c.2991G>A	p.S997S	Substitution - coding silent	Large_intestine
COSM1680488	c.3609A>C	p.K1203N	Substitution - Missense	Large_intestine
COSM1204457	c.1238G>A	p.R413H	Substitution - Missense	Large_intestine
COSM460002	c.4317C>T	p.L1439L	Substitution - coding silent	Cervix
COSM4796453	c.907G>A	p.V303M	Substitution - Missense	Liver
COSM1733880	c.1027C>T	p.R343C	Substitution - Missense	Pancreas
COSM1750765	c.1369C>G	p.H457D	Substitution - Missense	Urinary_tract
COSM5019840	c.1275G>A	p.K425K	Substitution - coding silent	Soft_tissue
COSM3822500	c.345C>A	p.Y115*	Substitution - Nonsense	Breast
COSM5470954	c.4185G>A	p.P1395P	Substitution - coding silent	Large_intestine
COSM5563754	c.1386G>A	p.Q462Q	Substitution - coding silent	Prostate
COSM5573647	c.5198C>T	p.S1733L	Substitution - Missense	Prostate
COSM84465	c.1311C>T	p.H437H	Substitution - coding silent	Pancreas
COSM4679191	c.466G>A	p.D156N	Substitution - Missense	Large_intestine
COSM1304323	c.3339C>T	p.V1113V	Substitution - coding silent	Urinary_tract
COSM3531382	c.120C>T	p.T40T	Substitution - coding silent	Skin
COSM1196307	c.493G>T	p.G165C	Substitution - Missense	Lung
COSM4480631	c.2438C>T	p.P813L	Substitution - Missense	Skin
COSM4436287	c.2849C>T	p.A950V	Substitution - Missense	Oesophagus
COSM1196121	c.3031C>T	p.R1011W	Substitution - Missense	Lung
COSM5715409	c.2024G>A	p.G675E	Substitution - Missense	Skin
COSM993704	c.114C>T	p.I38I	Substitution - coding silent	Endometrium
COSM1718683	c.1095C>T	p.A365A	Substitution - coding silent	Skin
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM4796453	c.907G>A	p.V303M	Substitution - Missense	Liver
COSM5715409	c.2024G>A	p.G675E	Substitution - Missense	Skin
COSM5510982	c.1991C>T	p.P664L	Substitution - Missense	Biliary_tract
COSM710749	c.2462G>C	p.G821A	Substitution - Missense	Oesophagus
COSM1392052	c.3422C>T	p.T1141I	Substitution - Missense	Large_intestine
COSM5608303	c.804C>T	p.S268S	Substitution - coding silent	Skin
COSM993837	c.2803G>T	p.A935S	Substitution - Missense	Endometrium
COSM160571	c.585G>A	p.A195A	Substitution - coding silent	Breast
COSM1204453	c.4294G>A	p.A1432T	Substitution - Missense	Large_intestine
COSM3531633	c.5130C>T	p.A1710A	Substitution - coding silent	Skin
COSM4877365	c.4337C>T	p.P1446L	Substitution - Missense	Prostate
COSM993706	c.202T>C	p.F68L	Substitution - Missense	Endometrium
COSM3892129	c.2652C>T	p.P884P	Substitution - coding silent	Skin
COSM993839	c.3645G>A	p.P1215P	Substitution - coding silent	Large_intestine
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM127840	c.1575C>T	p.L525L	Substitution - coding silent	Upper_aerodigestive_tract
COSM3989875	c.365C>G	p.P122R	Substitution - Missense	Kidney
COSM5921414	c.3633C>A	p.S1211R	Substitution - Missense	Skin
COSM5020729	c.2560G>A	p.A854T	Substitution - Missense	Soft_tissue
COSM4991279	c.396C>T	p.S132S	Substitution - coding silent	Skin
COSM5513426	c.3238G>T	p.G1080W	Substitution - Missense	Biliary_tract
COSM1204459	c.1031G>A	p.R344H	Substitution - Missense	Large_intestine
COSM4601569	c.3770C>T	p.A1257V	Substitution - Missense	Upper_aerodigestive_tract
COSM1196307	c.493G>T	p.G165C	Substitution - Missense	Lung
COSM5017269	c.359_364delCCGACC	p.D121_P122delDP	Deletion - In frame	Kidney
COSM5755321	c.629G>A	p.G210E	Substitution - Missense	Large_intestine
COSM3756558	c.4252G>C	p.V1418L	Substitution - Missense	Large_intestine
COSM1204463	c.583G>A	p.A195T	Substitution - Missense	Large_intestine
COSM3783222	c.4223G>A	p.G1408D	Substitution - Missense	Prostate
COSM3783220	c.3012C>T	p.H1004H	Substitution - coding silent	Prostate
COSM5985423	c.164T>C	p.M55T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM993717	c.552C>T	p.G184G	Substitution - coding silent	Oesophagus
COSM5505947	c.2459C>A	p.P820H	Substitution - Missense	Biliary_tract
COSM5606488	c.4392C>T	p.F1464F	Substitution - coding silent	Skin
COSM5504431	c.1781G>A	p.G594D	Substitution - Missense	Biliary_tract
COSM5389222	c.1100C>T	p.P367L	Substitution - Missense	Skin
COSM4827114	c.3812C>T	p.S1271F	Substitution - Missense	Cervix
COSM4623899	c.4161G>T	p.K1387N	Substitution - Missense	Large_intestine
COSM5470955	c.4838C>T	p.A1613V	Substitution - Missense	Large_intestine
COSM3531616	c.4422C>T	p.F1474F	Substitution - coding silent	Skin
COSM5510984	c.2490G>A	p.P830P	Substitution - coding silent	Biliary_tract
COSM710753	c.2211G>T	p.Q737H	Substitution - Missense	Lung
COSM3103121	c.299C>T	p.T100M	Substitution - Missense	Large_intestine
COSM4679205	c.2242G>A	p.V748M	Substitution - Missense	Large_intestine
COSM3531634	c.5147C>T	p.S1716F	Substitution - Missense	Skin
COSM5606488	c.4392C>T	p.F1464F	Substitution - coding silent	Skin
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Thyroid
COSM3822536	c.2712G>T	p.V904V	Substitution - coding silent	Breast
COSM2747643	c.3151A>G	p.T1051A	Substitution - Missense	Large_intestine
COSM4416984	c.3391-5C>T	p.?	Unknown	Soft_tissue
COSM3531610	c.3749A>G	p.D1250G	Substitution - Missense	Skin
COSM5661891	c.3335C>T	p.S1112F	Substitution - Missense	Soft_tissue
COSM1129937	c.1225C>T	p.R409C	Substitution - Missense	Prostate
COSM1304297	c.1776C>A	p.L592L	Substitution - coding silent	Urinary_tract
COSM993705	c.177T>G	p.V59V	Substitution - coding silent	Endometrium
COSM5364993	c.242C>T	p.A81V	Substitution - Missense	Large_intestine
COSM5986568	c.2296_2297insTC	p.A767fs*1	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM6003454	c.1544T>A	p.L515Q	Substitution - Missense	Prostate
COSM5620717	c.1039C>T	p.R347C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3822534	c.2011C>T	p.L671L	Substitution - coding silent	Breast
COSM5013341	c.644A>T	p.E215V	Substitution - Missense	Kidney
COSM5573675	c.4866T>C	p.P1622P	Substitution - coding silent	Prostate
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM4991287	c.2709C>T	p.P903P	Substitution - coding silent	Skin
COSM5715409	c.2024G>A	p.G675E	Substitution - Missense	Skin
COSM5056467	c.4032G>A	p.A1344A	Substitution - coding silent	Stomach
COSM4679199	c.2042G>A	p.R681H	Substitution - Missense	Large_intestine
COSM225762	c.3772G>A	p.D1258N	Substitution - Missense	Skin
COSM5389220	c.669C>T	p.F223F	Substitution - coding silent	Skin
COSM4412759	c.440T>A	p.M147K	Substitution - Missense	Oesophagus
COSM4991287	c.2709C>T	p.P903P	Substitution - coding silent	Skin
COSM3796885	c.4260C>G	p.L1420L	Substitution - coding silent	Urinary_tract
COSM439079	c.137A>G	p.E46G	Substitution - Missense	Breast
COSM4936158	c.2508G>A	p.G836G	Substitution - coding silent	Liver
COSM1392039	c.1320C>T	p.T440T	Substitution - coding silent	Large_intestine
COSM1750767	c.1599C>T	p.L533L	Substitution - coding silent	Urinary_tract
COSM3388786	c.126-3C>T	p.?	Unknown	Pancreas
COSM5936451	c.1265C>T	p.P422L	Substitution - Missense	Skin
COSM5770746	c.3543C>T	p.S1181S	Substitution - coding silent	Breast
COSM993744	c.1232G>A	p.R411H	Substitution - Missense	Endometrium
COSM3531575	c.2327C>T	p.P776L	Substitution - Missense	Skin
COSM3103062	c.142A>T	p.I48F	Substitution - Missense	Large_intestine
COSM5702387	c.2700_2701CC>TT	p.P901S	Substitution - Missense	Soft_tissue
COSM5606488	c.4392C>T	p.F1464F	Substitution - coding silent	Skin
COSM4454017	c.3881A>C	p.K1294T	Substitution - Missense	Skin
COSM5056469	c.4034C>A	p.A1345D	Substitution - Missense	Stomach
COSM4076236	c.1602C>T	p.S534S	Substitution - coding silent	Stomach
COSM417660	c.1947G>A	p.K649K	Substitution - coding silent	Urinary_tract
COSM1392041	c.1777C>T	p.R593C	Substitution - Missense	Large_intestine
COSM4973783	c.2983C>T	p.R995W	Substitution - Missense	Oesophagus
COSM5608293	c.572C>A	p.P191Q	Substitution - Missense	Skin
COSM1158331	c.965T>G	p.L322R	Substitution - Missense	Pancreas
COSM993746	c.1407G>T	p.R469R	Substitution - coding silent	Endometrium
COSM5698327	c.3007G>T	p.A1003S	Substitution - Missense	Soft_tissue
COSM4953289	c.2345G>T	p.R782M	Substitution - Missense	Liver
COSM1204451	c.3779C>T	p.P1260L	Substitution - Missense	Large_intestine
COSM1392048	c.2818G>A	p.A940T	Substitution - Missense	Large_intestine
COSM5972826	c.1701G>A	p.A567A	Substitution - coding silent	Upper_aerodigestive_tract
COSM5028456	c.734T>G	p.F245C	Substitution - Missense	Breast
COSM5430979	c.4803G>C	p.P1601P	Substitution - coding silent	Oesophagus
COSM84464	c.1057G>A	p.A353T	Substitution - Missense	Pancreas
COSM3531605	c.3312C>T	p.S1104S	Substitution - coding silent	Skin
COSM439085	c.1609C>G	p.Q537E	Substitution - Missense	Breast
COSM3531614	c.4370C>T	p.S1457F	Substitution - Missense	Skin
COSM993717	c.552C>T	p.G184G	Substitution - coding silent	Endometrium
COSM993744	c.1232G>A	p.R411H	Substitution - Missense	Large_intestine
COSM1718683	c.1095C>T	p.A365A	Substitution - coding silent	Skin
COSM5937796	c.2728C>T	p.P910S	Substitution - Missense	Skin
COSM474436	c.1404G>A	p.Q468Q	Substitution - coding silent	Kidney
COSM4411178	c.3751A>C	p.I1251L	Substitution - Missense	Kidney
COSM1750767	c.1599C>T	p.L533L	Substitution - coding silent	Urinary_tract
COSM4076205	c.353C>T	p.S118L	Substitution - Missense	Stomach
COSM1661545	c.852G>C	p.L284F	Substitution - Missense	Kidney
COSM5606488	c.4392C>T	p.F1464F	Substitution - coding silent	Skin
COSM3103070	c.204C>T	p.F68F	Substitution - coding silent	Large_intestine
COSM5365564	c.200+2T>C	p.?	Unknown	Large_intestine
COSM5608301	c.1242C>T	p.P414P	Substitution - coding silent	Skin
COSM4496331	c.472C>T	p.L158L	Substitution - coding silent	Skin
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM5470952	c.239G>A	p.R80H	Substitution - Missense	Large_intestine
COSM3721557	c.2555A>G	p.E852G	Substitution - Missense	Upper_aerodigestive_tract
COSM417657	c.2343G>A	p.L781L	Substitution - coding silent	Urinary_tract
COSM5774169	c.3078A>G	p.G1026G	Substitution - coding silent	Breast
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM1611971	c.4849G>A	p.V1617I	Substitution - Missense	Liver
COSM5770198	c.1410C>G	p.H470Q	Substitution - Missense	Breast
COSM2747810	c.4972delC	p.T1660fs*>79	Deletion - Frameshift	Prostate
COSM710745	c.2659A>T	p.S887C	Substitution - Missense	Lung
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM4621066	c.2844C>T	p.A948A	Substitution - coding silent	Large_intestine
COSM341126	c.742G>T	p.E248*	Substitution - Nonsense	Lung
COSM1304317	c.2406G>A	p.S802S	Substitution - coding silent	Urinary_tract
COSM4679207	c.2803G>A	p.A935T	Substitution - Missense	Large_intestine
COSM417667	c.1135G>A	p.E379K	Substitution - Missense	Urinary_tract
COSM993841	c.3912C>T	p.D1304D	Substitution - coding silent	Endometrium
COSM5961759	c.877G>A	p.V293M	Substitution - Missense	Adrenal_gland
COSM2747562	c.2190G>A	p.S730S	Substitution - coding silent	Large_intestine
COSM310696	c.1999G>T	p.D667Y	Substitution - Missense	Lung
COSM3404032	c.4510G>A	p.A1504T	Substitution - Missense	Central_nervous_system
COSM5043139	c.136G>T	p.E46*	Substitution - Nonsense	Liver
COSM5763160	c.1466-5C>T	p.?	Unknown	Large_intestine
COSM5520501	c.1833G>A	p.W611*	Substitution - Nonsense	Biliary_tract
COSM5824333	c.1497G>T	p.L499L	Substitution - coding silent	Liver
COSM1391999	c.160G>A	p.A54T	Substitution - Missense	Large_intestine
COSM3989881	c.2355G>A	p.L785L	Substitution - coding silent	Kidney
COSM3822505	c.718G>A	p.V240M	Substitution - Missense	Breast
COSM4936456	c.725A>G	p.N242S	Substitution - Missense	Liver
COSM1611966	c.2744A>G	p.E915G	Substitution - Missense	Liver
COSM439084	c.1466-1G>T	p.?	Unknown	Breast
COSM3822538	c.3399C>T	p.N1133N	Substitution - coding silent	Breast
COSM310696	c.1999G>T	p.D667Y	Substitution - Missense	Soft_tissue
COSM1318346	c.2328G>C	p.P776P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM4580863	c.1335G>A	p.A445A	Substitution - coding silent	Bone
COSM5623173	c.1499C>A	p.A500E	Substitution - Missense	Oesophagus
COSM417659	c.1963G>T	p.E655*	Substitution - Nonsense	Urinary_tract
COSM474435	c.829T>C	p.F277L	Substitution - Missense	Kidney
COSM710749	c.2462G>C	p.G821A	Substitution - Missense	Lung
COSM5493759	c.3257G>A	p.R1086H	Substitution - Missense	Biliary_tract
COSM5937794	c.2729C>T	p.P910L	Substitution - Missense	Skin
COSM4679201	c.2145C>T	p.G715G	Substitution - coding silent	Large_intestine
COSM4076232	c.1234G>A	p.G412R	Substitution - Missense	Stomach
COSM1680490	c.3950C>T	p.T1317I	Substitution - Missense	Large_intestine
COSM210959	c.1288C>T	p.Q430*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5021078	c.3438G>A	p.P1146P	Substitution - coding silent	Soft_tissue
COSM993745	c.1406G>A	p.R469Q	Substitution - Missense	Endometrium
COSM993836	c.2169C>T	p.C723C	Substitution - coding silent	Endometrium
COSM3756558	c.4252G>C	p.V1418L	Substitution - Missense	Large_intestine
COSM1611968	c.3542C>T	p.S1181F	Substitution - Missense	Liver
COSM5755323	c.1004G>A	p.R335K	Substitution - Missense	Large_intestine
COSM5883074	c.42G>A	p.G14G	Substitution - coding silent	Soft_tissue
COSM1611968	c.3542C>T	p.S1181F	Substitution - Missense	Liver
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM405060	c.3146_3147insCA	p.T1051fs*18	Insertion - Frameshift	Lung
COSM474437	c.1845G>A	p.S615S	Substitution - coding silent	Kidney
COSM133560	c.1316_1318AGA>CCG	p.Q439_T440>PP	Complex - compound substitution	Ovary
COSM4829536	c.2545-2A>G	p.?	Unknown	Cervix
COSM5914070	c.4349C>T	p.S1450F	Substitution - Missense	Skin
COSM1204448	c.1291A>G	p.T431A	Substitution - Missense	Large_intestine
COSM1661547	c.2945G>C	p.S982T	Substitution - Missense	Kidney
COSM3531573	c.2225C>A	p.P742H	Substitution - Missense	Skin
COSM5961786	c.671T>C	p.L224P	Substitution - Missense	Adrenal_gland
COSM4849031	c.3604-1G>C	p.?	Unknown	Cervix
COSM355096	c.2033C>T	p.A678V	Substitution - Missense	Lung
COSM4076307	c.2218G>A	p.A740T	Substitution - Missense	Stomach
COSM5608295	c.3458C>T	p.S1153F	Substitution - Missense	Skin
COSM1250598	c.4499C>T	p.S1500F	Substitution - Missense	Oesophagus
COSM4580865	c.1394C>T	p.P465L	Substitution - Missense	Bone
COSM5608297	c.2702C>T	p.P901L	Substitution - Missense	Skin
COSM4513814	c.951C>T	p.I317I	Substitution - coding silent	Skin
COSM2747733	c.4339_4359del21	p.G1452_A1458delGGAASSA	Deletion - In frame	Upper_aerodigestive_tract
COSM1304295	c.1002C>T	p.L334L	Substitution - coding silent	Urinary_tract
COSM4420551	c.3748G>A	p.D1250N	Substitution - Missense	Central_nervous_system
COSM1392037	c.838A>C	p.N280H	Substitution - Missense	Large_intestine
COSM3388797	c.5088C>T	p.P1696P	Substitution - coding silent	Pancreas
COSM2149861	c.2384_2386delCGG	p.A797delA	Deletion - In frame	Central_nervous_system
COSM4411178	c.3751A>C	p.I1251L	Substitution - Missense	Kidney
COSM1611970	c.4622C>T	p.A1541V	Substitution - Missense	Liver
COSM5608299	c.2880C>T	p.A960A	Substitution - coding silent	Skin
COSM5606486	c.3889C>T	p.P1297S	Substitution - Missense	Skin
COSM3531586	c.2495C>T	p.P832L	Substitution - Missense	Skin
COSM4991281	c.933C>T	p.S311S	Substitution - coding silent	Skin
COSM5778396	c.861C>G	p.I287M	Substitution - Missense	Breast
COSM710869	c.175G>A	p.V59I	Substitution - Missense	Lung
COSM4679203	c.2193G>A	p.S731S	Substitution - coding silent	Large_intestine
COSM1716187	c.1773G>A	p.A591A	Substitution - coding silent	Central_nervous_system
COSM376270	c.2526_2527AG>TT	p.G842>?	Complex	Lung
COSM5755321	c.629G>A	p.G210E	Substitution - Missense	Large_intestine
COSM5680068	c.1102G>T	p.A368S	Substitution - Missense	Soft_tissue
COSM3531603	c.3030C>T	p.P1010P	Substitution - coding silent	Skin
COSM5365720	c.2002G>A	p.A668T	Substitution - Missense	Large_intestine
COSM4416984	c.3391-5C>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM439085	c.1609C>G	p.Q537E	Substitution - Missense	Breast
COSM4076210	c.494-1G>A	p.?	Unknown	Stomach
COSM5741336	c.1664G>A	p.G555D	Substitution - Missense	Small_intestine
COSM5606486	c.3889C>T	p.P1297S	Substitution - Missense	Skin
COSM1304321	c.2931C>T	p.T977T	Substitution - coding silent	Stomach
COSM4829813	c.1315C>T	p.Q439*	Substitution - Nonsense	Cervix
COSM1304292	c.618G>A	p.M206I	Substitution - Missense	Urinary_tract
COSM474450	c.3509G>A	p.R1170Q	Substitution - Missense	Kidney
COSM6003454	c.1544T>A	p.L515Q	Substitution - Missense	Prostate
COSM3692569	c.1778G>A	p.R593H	Substitution - Missense	Large_intestine
COSM1304290	c.343T>A	p.Y115N	Substitution - Missense	Urinary_tract
COSM3531612	c.3813C>T	p.S1271S	Substitution - coding silent	Skin
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM4991287	c.2709C>T	p.P903P	Substitution - coding silent	Skin
COSM3672825	c.3903G>T	p.S1301S	Substitution - coding silent	Prostate
COSM4679191	c.466G>A	p.D156N	Substitution - Missense	Oesophagus
COSM6003454	c.1544T>A	p.L515Q	Substitution - Missense	Prostate
COSM5628446	c.2321T>A	p.L774Q	Substitution - Missense	Oesophagus
COSM5365087	c.1983C>A	p.S661S	Substitution - coding silent	Large_intestine
COSM5715409	c.2024G>A	p.G675E	Substitution - Missense	Skin
COSM5657335	c.1006G>T	p.E336*	Substitution - Nonsense	Soft_tissue
COSM4416984	c.3391-5C>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM710870	c.159C>A	p.L53L	Substitution - coding silent	Lung
COSM4679195	c.956G>A	p.R319H	Substitution - Missense	Large_intestine
COSM4399722	c.3913G>A	p.G1305R	Substitution - Missense	Skin
COSM4936144	c.4196C>G	p.P1399R	Substitution - Missense	Liver
COSM3742853	c.1156G>A	p.V386M	Substitution - Missense	Liver
COSM1392035	c.798C>T	p.I266I	Substitution - coding silent	Large_intestine
COSM1480846	c.186C>A	p.D62E	Substitution - Missense	Breast
COSM5606488	c.4392C>T	p.F1464F	Substitution - coding silent	Skin
COSM26946	c.2544+5G>T	p.?	Unknown	Upper_aerodigestive_tract
COSM5896371	c.947C>T	p.T316I	Substitution - Missense	Skin
COSM4991291	c.4092C>T	p.A1364A	Substitution - coding silent	Skin
COSM3892132	c.4475C>T	p.S1492F	Substitution - Missense	Skin
COSM1680488	c.3609A>C	p.K1203N	Substitution - Missense	Large_intestine
COSM3822540	c.3574G>A	p.E1192K	Substitution - Missense	Breast
COSM3422598	c.1260G>A	p.A420A	Substitution - coding silent	Large_intestine
COSM5985425	c.4135C>A	p.L1379M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3531632	c.5075A>G	p.H1692R	Substitution - Missense	Skin
COSM993748	c.1565A>G	p.N522S	Substitution - Missense	Endometrium
COSM4623897	c.986T>C	p.L329P	Substitution - Missense	Large_intestine
COSM4472809	c.1807C>T	p.R603C	Substitution - Missense	Skin
COSM4598734	c.3160G>T	p.G1054C	Substitution - Missense	Upper_aerodigestive_tract
COSM1750765	c.1369C>G	p.H457D	Substitution - Missense	Urinary_tract
COSM993838	c.3425C>A	p.A1142D	Substitution - Missense	Endometrium
COSM3680850	c.4500T>G	p.S1500S	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM565877	c.2732C>T	p.S911L	Substitution - Missense	Thyroid
COSM3764719	c.355G>T	p.V119L	Substitution - Missense	Central_nervous_system
COSM4601556	c.1513C>A	p.P505T	Substitution - Missense	Upper_aerodigestive_tract
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM4991287	c.2709C>T	p.P903P	Substitution - coding silent	Skin
COSM4679193	c.705G>A	p.T235T	Substitution - coding silent	Large_intestine
COSM5611255	c.4096_4097CC>AT	p.P1366I	Substitution - Missense	Skin
COSM5020860	c.2478C>T	p.S826S	Substitution - coding silent	Soft_tissue
COSM336558	c.2043C>T	p.R681R	Substitution - coding silent	Lung
COSM3531633	c.5130C>T	p.A1710A	Substitution - coding silent	Ovary
COSM4076316	c.4002T>C	p.G1334G	Substitution - coding silent	Stomach
COSM4421159	c.901G>C	p.G301R	Substitution - Missense	Pleura
COSM5961795	c.1340_1348delCCTCACCCC	p.S447_Q450>*	Complex - deletion inframe	Adrenal_gland
COSM5985423	c.164T>C	p.M55T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5755321	c.629G>A	p.G210E	Substitution - Missense	Large_intestine
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM5633083	c.2343G>C	p.L781L	Substitution - coding silent	Oesophagus
COSM336559	c.4328G>T	p.G1443V	Substitution - Missense	Lung
COSM3531403	c.674C>T	p.S225L	Substitution - Missense	Skin
COSM4570719	c.3100T>G	p.F1034V	Substitution - Missense	Skin
COSM2747680	c.3623C>T	p.S1208F	Substitution - Missense	Skin
COSM710854	c.1096G>T	p.G366C	Substitution - Missense	Lung
COSM4076238	c.1772C>T	p.A591V	Substitution - Missense	Stomach
COSM5573647	c.5198C>T	p.S1733L	Substitution - Missense	Prostate
COSM3989883	c.3674C>T	p.A1225V	Substitution - Missense	Kidney
COSM266413	c.691C>T	p.R231*	Substitution - Nonsense	Large_intestine
COSM993744	c.1232G>A	p.R411H	Substitution - Missense	Endometrium
COSM5389239	c.3570C>T	p.G1190G	Substitution - coding silent	Skin
COSM5365087	c.1983C>A	p.S661S	Substitution - coding silent	Large_intestine
COSM252480	c.146C>T	p.P49L	Substitution - Missense	Ovary
COSM417664	c.1668G>A	p.V556V	Substitution - coding silent	Urinary_tract
COSM2747705	c.3827G>A	p.R1276Q	Substitution - Missense	Large_intestine
COSM5606486	c.3889C>T	p.P1297S	Substitution - Missense	Skin
COSM5658312	c.3996T>C	p.S1332S	Substitution - coding silent	Soft_tissue
COSM4679197	c.1874C>A	p.A625D	Substitution - Missense	Large_intestine
COSM5755325	c.1399G>A	p.V467M	Substitution - Missense	Large_intestine
COSM5548327	c.3046G>A	p.A1016T	Substitution - Missense	Prostate
COSM5494610	c.2574C>T	p.S858S	Substitution - coding silent	Biliary_tract
COSM5476049	c.1690C>T	p.L564L	Substitution - coding silent	Large_intestine
COSM1204455	c.1108G>A	p.A370T	Substitution - Missense	Large_intestine
COSM5430362	c.3167C>G	p.A1056G	Substitution - Missense	Oesophagus
COSM4679211	c.4297G>A	p.V1433M	Substitution - Missense	Large_intestine
COSM4746504	c.3646delA	p.T1217fs*110	Deletion - Frameshift	Stomach
COSM5573647	c.5198C>T	p.S1733L	Substitution - Missense	Prostate
COSM5585044	c.3029C>T	p.P1010L	Substitution - Missense	Skin
COSM5365605	c.4984G>A	p.A1662T	Substitution - Missense	Large_intestine
COSM3959787	c.1840C>G	p.L614V	Substitution - Missense	Lung
COSM1158331	c.965T>G	p.L322R	Substitution - Missense	Pancreas
COSM4445834	c.4834C>T	p.P1612S	Substitution - Missense	Skin
COSM4076203	c.331C>A	p.L111M	Substitution - Missense	Stomach
COSM3749492	c.4156G>A	p.G1386S	Substitution - Missense	Large_intestine
COSM341784	c.1585G>C	p.A529P	Substitution - Missense	Lung
COSM5474122	c.3970G>A	p.A1324T	Substitution - Missense	Large_intestine
COSM5389237	c.2496C>T	p.P832P	Substitution - coding silent	Skin
COSM5020470	c.1465+10T>C	p.?	Unknown	Soft_tissue
COSM4679209	c.4143C>T	p.G1381G	Substitution - coding silent	Large_intestine
COSM1611970	c.4622C>T	p.A1541V	Substitution - Missense	Liver
COSM4580863	c.1335G>A	p.A445A	Substitution - coding silent	Large_intestine
COSM1680490	c.3950C>T	p.T1317I	Substitution - Missense	Large_intestine
COSM3932973	c.1344A>C	p.S448S	Substitution - coding silent	Urinary_tract
COSM4076200	c.271G>T	p.G91C	Substitution - Missense	Stomach
COSM5585044	c.3029C>T	p.P1010L	Substitution - Missense	Skin

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
28231254	Mutation (gain of function)	Acute Myeloid Leukemia with Variant MLL Translocations	We used this approach to identify novel resistance alleles of two lysine methyltransferases, DOT1L and EZH2, which are each essential for the growth of MLL-fusion leukemia cells. We biochemically characterized the DOT1L mutation, showing that it is significantly more active than the wild-type enzyme.
27683039	Mutation	Hyperdiploid B Acute Lymphoblastic Leukemia	One-third of patients harbored damaging mutations in epigenetic regulatory genes, including the putative novel driver DOT1L (n=4). Mutations in FLT3 significantly co-occurred with DOT1L (p=0.04), suggesting functional cooperation in leukemogenesis.
27683039	Mutation	Leukemia	Mutations in FLT3 significantly co-occurred with DOT1L (p=0.04), suggesting functional cooperation in leukemogenesis.
27158780	Mutation	Lung Adenocarcinoma	New significantly mutated genes included PPP3CA, DOT1L, and FTSJD1 in lung ADC, RASA1 in lung SqCC, and KLF5, EP300, and CREBBP in both tumor types.
26927674	Mutation	Acute Myeloid Leukemia	Here, we have shown that this program is controlled by two histone methyltransferases, MLL1 and DOT1L, as deletion of either Mll1 or Dot1l in MN1-expressing cells abrogated the cell of origin-derived gene expression program, including the expression of Hoxa cluster genes.
25592767	Mutation	Leukemia	Histone methyltransferases, including MLL1, DOT1L, EZH2, and SETD2 are recurrently deregulated in human leukemia, either directly by gene mutations or balanced translocations, or indirectly as components of protein complexes that are disturbed in leukemia due to alterations of the other components in these complexes.
25576241	Mutation	Gastric Carcinoma	The shared variants which were predicted deleterious in silico and could not be found in databases or in a control set of over 4,000 individuals were Sanger sequenced in a third family member. Three candidate variants were identified: p.Glu1313Lys in Insulin receptor (INSR), p.Arg81Pro in F-box protein 24 (FBXO24) and p.Pro1146Leu in DOT1-like histone H3K79 methyltransferase (DOT1L).

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8TEK3	374	S	Phosphoserine	-	No	None detected
Q8TEK3	448	S	Phosphoserine	-	No	None detected
Q8TEK3	471	S	Phosphoserine	-	No	None detected
Q8TEK3	480	T	Phosphothreonine	-	No	None detected
Q8TEK3	775	S	Phosphoserine	-	No	None detected
Q8TEK3	786	S	Phosphoserine	-	No	None detected
Q8TEK3	826	S	Phosphoserine	-	No	None detected
Q8TEK3	834	S	Phosphoserine	-	No	None detected
Q8TEK3	900	T	Phosphothreonine	-	No	None detected
Q8TEK3	902	S	Phosphoserine	-	No	None detected
Q8TEK3	984	T	Phosphothreonine	-	No	None detected
Q8TEK3	997	S	Phosphoserine	-	No	None detected
Q8TEK3	1001	S	Phosphoserine	-	No	None detected
Q8TEK3	1009	S	Phosphoserine	-	No	None detected
Q8TEK3	1035	S	Phosphoserine	-	Yes	p.S1035* (cancer: LUAD)
Q8TEK3	1093	S	Phosphoserine	-	No	None detected
Q8TEK3	1104	S	Phosphoserine	-	No	None detected
Q8TEK3	1213	S	Phosphoserine	-	No	None detected
Q8TEK3	1246	S	Phosphoserine	-	No	None detected

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.042	5.568	0.498	0.00274	NS
BRCA	Breast invasive carcinoma	112	1100	4.431	4.936	0.547	5.27e-18	NS
CESC	Cervical and endocervical cancers	3	306	4.352	5.941	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.013	5.897	0.001	0.996	NS
ESCA	Esophageal carcinoma	11	185	6.313	6.687	0.043	0.87	NS
GBM	Glioblastoma multiforme	5	166	5.12	5.877	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.664	5.635	0.135	0.176	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.348	4.63	0.301	0.0014	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.184	4.967	-0.164	0.177	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.351	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.879	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.972	4.686	0.586	7.66e-07	Over
LUAD	Lung adenocarcinoma	59	517	5.683	5.114	-0.584	1.95e-08	Under
LUSC	Lung squamous cell carcinoma	51	501	5.574	5.534	-0.061	0.618	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.391	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.647	5.336	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.853	4.575	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.274	4.929	0.693	3.49e-17	Over
READ	Rectum adenocarcinoma	10	167	5.759	5.852	0.439	0.103	NS
SARC	Sarcoma	2	263	4.248	5.544	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.115	5.92	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.344	6.322	0.259	0.057	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.383	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.925	4.549	-0.372	2.36e-10	NS
THYM	Thymoma	2	120	6.393	5.958	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.827	5.65	0.793	1.39e-11	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6.3
Autonomic ganglia	CHP212	6.3
Autonomic ganglia	IMR32	6.8
Autonomic ganglia	KELLY	6.2
Autonomic ganglia	KPNRTBM1	7.1
Autonomic ganglia	KPNSI9S	5.4
Autonomic ganglia	KPNYN	6.7
Autonomic ganglia	MHHNB11	7.7
Autonomic ganglia	NB1	6.6
Autonomic ganglia	NH6	6.2
Autonomic ganglia	SHSY5Y	6.6
Autonomic ganglia	SIMA	6.2
Autonomic ganglia	SKNAS	6.2
Autonomic ganglia	SKNBE2	6.6
Autonomic ganglia	SKNDZ	6.3
Autonomic ganglia	SKNFI	6.2
Autonomic ganglia	SKNSH	5.8
Biliary tract	HUCCT1	5.8
Biliary tract	HUH28	5.9
Biliary tract	SNU1079	6.1
Biliary tract	SNU1196	6.2
Biliary tract	SNU245	6.4
Biliary tract	SNU308	6.2
Biliary tract	SNU478	6.3
Bone	143B	6.7
Bone	A673	6.2
Bone	CADOES1	6.2
Bone	CAL78	6.2
Bone	G292CLONEA141B1	6
Bone	HOS	6.5
Bone	HS706T	5.7
Bone	HS737T	5.8
Bone	HS819T	5.6
Bone	HS821T	5.9
Bone	HS822T	5.8
Bone	HS863T	6.1
Bone	HS870T	6.2
Bone	HS888T	6.1
Bone	MG63	5.7
Bone	MHHES1	6.3
Bone	OUMS27	5.4
Bone	RDES	6.2
Bone	SJSA1	6.2
Bone	SKES1	6.3
Bone	SKNMC	6.8
Bone	SW1353	6.3
Bone	T173	5.8
Bone	TC71	6.7
Bone	U2OS	6.1
Breast	AU565	6
Breast	BT20	6.5
Breast	BT474	6.1
Breast	BT483	5.9
Breast	BT549	6.6
Breast	CAL120	5.9
Breast	CAL148	6.6
Breast	CAL51	6.6
Breast	CAL851	6.2
Breast	CAMA1	6.3
Breast	DU4475	6.6
Breast	EFM192A	6.1
Breast	EFM19	6.6
Breast	EVSAT	6.1
Breast	HCC1143	6.1
Breast	HCC1187	5.9
Breast	HCC1395	5.9
Breast	HCC1419	6.6
Breast	HCC1428	6.3
Breast	HCC1500	6.3
Breast	HCC1569	6.3
Breast	HCC1599	6.2
Breast	HCC1806	6
Breast	HCC1937	5.9
Breast	HCC1954	5.8
Breast	HCC202	6.4
Breast	HCC2157	6.4
Breast	HCC2218	5.8
Breast	HCC38	5.9
Breast	HCC70	5.8
Breast	HDQP1	5.7
Breast	HMC18	6
Breast	HS274T	6.2
Breast	HS281T	5.9
Breast	HS343T	6
Breast	HS578T	6.1
Breast	HS606T	5.7
Breast	HS739T	5.7
Breast	HS742T	5.6
Breast	JIMT1	6.1
Breast	KPL1	6.1
Breast	MCF7	6.1
Breast	MDAMB134VI	6.3
Breast	MDAMB157	5.4
Breast	MDAMB175VII	6
Breast	MDAMB231	6.4
Breast	MDAMB361	6.1
Breast	MDAMB415	5.9
Breast	MDAMB436	5.9
Breast	MDAMB453	6.7
Breast	MDAMB468	6.3
Breast	SKBR3	6.8
Breast	T47D	6.1
Breast	UACC812	6.8
Breast	UACC893	6.5
Breast	YMB1	6.3
Breast	ZR751	6
Breast	ZR7530	6.1
Central nervous system	1321N1	5.9
Central nervous system	42MGBA	6
Central nervous system	8MGBA	5.6
Central nervous system	A172	6.4
Central nervous system	AM38	5.9
Central nervous system	BECKER	6
Central nervous system	CAS1	5.8
Central nervous system	CCFSTTG1	6.3
Central nervous system	D283MED	6.6
Central nervous system	D341MED	6.5
Central nervous system	DAOY	6.3
Central nervous system	DBTRG05MG	6
Central nervous system	DKMG	6.5
Central nervous system	GAMG	6
Central nervous system	GB1	6.8
Central nervous system	GI1	6.2
Central nervous system	GMS10	6.2
Central nervous system	GOS3	6.1
Central nervous system	H4	5.8
Central nervous system	HS683	5.8
Central nervous system	KALS1	5.9
Central nervous system	KG1C	5.5
Central nervous system	KNS42	6.4
Central nervous system	KNS60	6
Central nervous system	KNS81	6
Central nervous system	KS1	6
Central nervous system	LN18	6.1
Central nervous system	LN229	6.1
Central nervous system	M059K	6.2
Central nervous system	MOGGCCM	6.3
Central nervous system	MOGGUVW	6.1
Central nervous system	NMCG1	5.9
Central nervous system	ONS76	6
Central nervous system	SF126	5.8
Central nervous system	SF295	6.4
Central nervous system	SNB19	6.2
Central nervous system	SNU1105	6.2
Central nervous system	SNU201	6
Central nervous system	SNU466	6.2
Central nervous system	SNU489	6.3
Central nervous system	SNU626	6.6
Central nervous system	SNU738	6.4
Central nervous system	SW1088	6
Central nervous system	SW1783	5.8
Central nervous system	T98G	5.8
Central nervous system	TM31	6.4
Central nervous system	U118MG	6.9
Central nervous system	U138MG	6.2
Central nervous system	U251MG	6.1
Central nervous system	U87MG	6.8
Central nervous system	YH13	6
Central nervous system	YKG1	6
Endometrium	AN3CA	6.8
Endometrium	COLO684	7.4
Endometrium	EFE184	5.6
Endometrium	EN	5.8
Endometrium	ESS1	5.6
Endometrium	HEC108	5.8
Endometrium	HEC151	6.1
Endometrium	HEC1A	6.1
Endometrium	HEC1B	6.2
Endometrium	HEC251	5.9
Endometrium	HEC265	6.1
Endometrium	HEC50B	6
Endometrium	HEC59	7
Endometrium	HEC6	6.3
Endometrium	ISHIKAWAHERAKLIO02ER	5.9
Endometrium	JHUEM1	6.3
Endometrium	JHUEM2	6.2
Endometrium	JHUEM3	5.5
Endometrium	KLE	5.7
Endometrium	MFE280	5.8
Endometrium	MFE296	6.5
Endometrium	MFE319	6.2
Endometrium	RL952	6.2
Endometrium	SNGM	6.1
Endometrium	SNU1077	5.8
Endometrium	SNU685	6.6
Endometrium	TEN	6.3
Haematopoietic and lymphoid	697	6.8
Haematopoietic and lymphoid	A3KAW	6.4
Haematopoietic and lymphoid	A4FUK	7
Haematopoietic and lymphoid	ALLSIL	7.1
Haematopoietic and lymphoid	AML193	7.4
Haematopoietic and lymphoid	AMO1	7
Haematopoietic and lymphoid	BCP1	7.2
Haematopoietic and lymphoid	BDCM	6.7
Haematopoietic and lymphoid	BL41	7.4
Haematopoietic and lymphoid	BL70	7.2
Haematopoietic and lymphoid	BV173	8.4
Haematopoietic and lymphoid	CA46	6.4
Haematopoietic and lymphoid	CI1	6.9
Haematopoietic and lymphoid	CMK115	6.7
Haematopoietic and lymphoid	CMK86	7.3
Haematopoietic and lymphoid	CMK	6.9
Haematopoietic and lymphoid	CMLT1	6.4
Haematopoietic and lymphoid	COLO775	7.4
Haematopoietic and lymphoid	DAUDI	6.5
Haematopoietic and lymphoid	DB	6.6
Haematopoietic and lymphoid	DEL	6.3
Haematopoietic and lymphoid	DND41	7.1
Haematopoietic and lymphoid	DOHH2	6.9
Haematopoietic and lymphoid	EB1	6.8
Haematopoietic and lymphoid	EB2	6.9
Haematopoietic and lymphoid	EHEB	7.8
Haematopoietic and lymphoid	EJM	6.7
Haematopoietic and lymphoid	EM2	7
Haematopoietic and lymphoid	EOL1	6.9
Haematopoietic and lymphoid	F36P	6.3
Haematopoietic and lymphoid	GA10	7.1
Haematopoietic and lymphoid	GDM1	6.3
Haematopoietic and lymphoid	GRANTA519	7.3
Haematopoietic and lymphoid	HDLM2	6.4
Haematopoietic and lymphoid	HDMYZ	6.1
Haematopoietic and lymphoid	HEL9217	6.8
Haematopoietic and lymphoid	HEL	7
Haematopoietic and lymphoid	HH	6.8
Haematopoietic and lymphoid	HL60	7.8
Haematopoietic and lymphoid	HPBALL	7.4
Haematopoietic and lymphoid	HS604T	5.9
Haematopoietic and lymphoid	HS611T	6.8
Haematopoietic and lymphoid	HS616T	5.9
Haematopoietic and lymphoid	HS751T	6.2
Haematopoietic and lymphoid	HT	6.3
Haematopoietic and lymphoid	HTK	7.2
Haematopoietic and lymphoid	HUNS1	6.9
Haematopoietic and lymphoid	HUT102	6.5
Haematopoietic and lymphoid	HUT78	6.5
Haematopoietic and lymphoid	JEKO1	7.7
Haematopoietic and lymphoid	JK1	7
Haematopoietic and lymphoid	JM1	6.7
Haematopoietic and lymphoid	JURKAT	6.3
Haematopoietic and lymphoid	JURLMK1	7.5
Haematopoietic and lymphoid	JVM2	7.8
Haematopoietic and lymphoid	JVM3	6.9
Haematopoietic and lymphoid	K562	7.1
Haematopoietic and lymphoid	KARPAS299	6.4
Haematopoietic and lymphoid	KARPAS422	6.5
Haematopoietic and lymphoid	KARPAS620	7
Haematopoietic and lymphoid	KASUMI1	6.8
Haematopoietic and lymphoid	KASUMI2	6.8
Haematopoietic and lymphoid	KASUMI6	6.3
Haematopoietic and lymphoid	KCL22	7
Haematopoietic and lymphoid	KE37	6.5
Haematopoietic and lymphoid	KE97	6.4
Haematopoietic and lymphoid	KG1	6.7
Haematopoietic and lymphoid	KHM1B	6.9
Haematopoietic and lymphoid	KIJK	6.8
Haematopoietic and lymphoid	KMH2	6.4
Haematopoietic and lymphoid	KMM1	6.6
Haematopoietic and lymphoid	KMS11	6.7
Haematopoietic and lymphoid	KMS12BM	6.9
Haematopoietic and lymphoid	KMS18	7.2
Haematopoietic and lymphoid	KMS20	7
Haematopoietic and lymphoid	KMS21BM	6.5
Haematopoietic and lymphoid	KMS26	6.3
Haematopoietic and lymphoid	KMS27	6.6
Haematopoietic and lymphoid	KMS28BM	6.4
Haematopoietic and lymphoid	KMS34	6.7
Haematopoietic and lymphoid	KO52	6.6
Haematopoietic and lymphoid	KOPN8	7.7
Haematopoietic and lymphoid	KU812	6.9
Haematopoietic and lymphoid	KYO1	6.9
Haematopoietic and lymphoid	L1236	6.2
Haematopoietic and lymphoid	L363	7.7
Haematopoietic and lymphoid	L428	6.5
Haematopoietic and lymphoid	L540	7
Haematopoietic and lymphoid	LAMA84	6.8
Haematopoietic and lymphoid	LOUCY	6.7
Haematopoietic and lymphoid	LP1	6.3
Haematopoietic and lymphoid	M07E	6.8
Haematopoietic and lymphoid	MC116	6.9
Haematopoietic and lymphoid	ME1	7.2
Haematopoietic and lymphoid	MEC1	6.5
Haematopoietic and lymphoid	MEC2	7.1
Haematopoietic and lymphoid	MEG01	6.3
Haematopoietic and lymphoid	MHHCALL2	6.7
Haematopoietic and lymphoid	MHHCALL3	7
Haematopoietic and lymphoid	MHHCALL4	7
Haematopoietic and lymphoid	MINO	7
Haematopoietic and lymphoid	MJ	6.4
Haematopoietic and lymphoid	MM1S	7.3
Haematopoietic and lymphoid	MOLM13	7.8
Haematopoietic and lymphoid	MOLM16	6.4
Haematopoietic and lymphoid	MOLM6	7
Haematopoietic and lymphoid	MOLP2	6.5
Haematopoietic and lymphoid	MOLP8	6.5
Haematopoietic and lymphoid	MOLT13	6.6
Haematopoietic and lymphoid	MOLT16	6.2
Haematopoietic and lymphoid	MOLT4	6.5
Haematopoietic and lymphoid	MONOMAC1	6.9
Haematopoietic and lymphoid	MONOMAC6	7.1
Haematopoietic and lymphoid	MOTN1	7.1
Haematopoietic and lymphoid	MUTZ5	6.4
Haematopoietic and lymphoid	MV411	8.3
Haematopoietic and lymphoid	NALM19	6.5
Haematopoietic and lymphoid	NALM1	6.9
Haematopoietic and lymphoid	NALM6	6.8
Haematopoietic and lymphoid	NAMALWA	7.4
Haematopoietic and lymphoid	NB4	7.3
Haematopoietic and lymphoid	NCIH929	6.7
Haematopoietic and lymphoid	NCO2	6.2
Haematopoietic and lymphoid	NOMO1	6.6
Haematopoietic and lymphoid	NUDHL1	7.6
Haematopoietic and lymphoid	NUDUL1	6.5
Haematopoietic and lymphoid	OCIAML2	7
Haematopoietic and lymphoid	OCIAML3	7.2
Haematopoietic and lymphoid	OCIAML5	7.2
Haematopoietic and lymphoid	OCILY10	6.7
Haematopoietic and lymphoid	OCILY19	7.5
Haematopoietic and lymphoid	OCILY3	6.4
Haematopoietic and lymphoid	OCIM1	6.2
Haematopoietic and lymphoid	OPM2	6.8
Haematopoietic and lymphoid	P12ICHIKAWA	6.9
Haematopoietic and lymphoid	P31FUJ	6.6
Haematopoietic and lymphoid	P3HR1	7.1
Haematopoietic and lymphoid	PCM6	6.7
Haematopoietic and lymphoid	PEER	6.4
Haematopoietic and lymphoid	PF382	6.7
Haematopoietic and lymphoid	PFEIFFER	6.5
Haematopoietic and lymphoid	PL21	6.8
Haematopoietic and lymphoid	RAJI	6.9
Haematopoietic and lymphoid	RCHACV	6.5
Haematopoietic and lymphoid	REC1	7.5
Haematopoietic and lymphoid	REH	6.5
Haematopoietic and lymphoid	RI1	7.4
Haematopoietic and lymphoid	RL	6.6
Haematopoietic and lymphoid	RPMI8226	6.6
Haematopoietic and lymphoid	RPMI8402	6.7
Haematopoietic and lymphoid	RS411	6.8
Haematopoietic and lymphoid	SEM	6.7
Haematopoietic and lymphoid	SET2	6.5
Haematopoietic and lymphoid	SIGM5	7.4
Haematopoietic and lymphoid	SKM1	6.6
Haematopoietic and lymphoid	SKMM2	6.5
Haematopoietic and lymphoid	SR786	6.6
Haematopoietic and lymphoid	ST486	6.3
Haematopoietic and lymphoid	SUDHL10	6.9
Haematopoietic and lymphoid	SUDHL1	7.4
Haematopoietic and lymphoid	SUDHL4	7.4
Haematopoietic and lymphoid	SUDHL5	7.6
Haematopoietic and lymphoid	SUDHL6	6.8
Haematopoietic and lymphoid	SUDHL8	7.3
Haematopoietic and lymphoid	SUPB15	6.6
Haematopoietic and lymphoid	SUPHD1	6.1
Haematopoietic and lymphoid	SUPM2	6.5
Haematopoietic and lymphoid	SUPT11	7.1
Haematopoietic and lymphoid	SUPT1	7
Haematopoietic and lymphoid	TALL1	6.8
Haematopoietic and lymphoid	TF1	6.7
Haematopoietic and lymphoid	THP1	6.7
Haematopoietic and lymphoid	TO175T	6.3
Haematopoietic and lymphoid	TOLEDO	6.6
Haematopoietic and lymphoid	U266B1	6.9
Haematopoietic and lymphoid	U937	7.1
Haematopoietic and lymphoid	UT7	6.4
Haematopoietic and lymphoid	WSUDLCL2	6.9
Kidney	769P	6.3
Kidney	786O	6.3
Kidney	A498	6.1
Kidney	A704	5.7
Kidney	ACHN	5.6
Kidney	BFTC909	6.4
Kidney	CAKI1	5.9
Kidney	CAKI2	5.6
Kidney	CAL54	5.7
Kidney	KMRC1	5.5
Kidney	KMRC20	4.9
Kidney	KMRC2	6
Kidney	KMRC3	5.8
Kidney	OSRC2	5.8
Kidney	RCC10RGB	5.2
Kidney	SNU1272	5.8
Kidney	SNU349	6.2
Kidney	TUHR10TKB	5.6
Kidney	TUHR14TKB	5.5
Kidney	TUHR4TKB	5.5
Kidney	VMRCRCW	5.7
Kidney	VMRCRCZ	5.8
Large intestine	C2BBE1	6.2
Large intestine	CCK81	6.4
Large intestine	CL11	6.2
Large intestine	CL14	6.3
Large intestine	CL34	6.2
Large intestine	CL40	6.3
Large intestine	COLO205	6.1
Large intestine	COLO320	6.5
Large intestine	COLO678	6.4
Large intestine	CW2	6.6
Large intestine	DLD1	6.3
Large intestine	GP2D	6.3
Large intestine	HCC56	6.2
Large intestine	HCT116	6.4
Large intestine	HCT15	6.6
Large intestine	HS675T	5.5
Large intestine	HS698T	6.2
Large intestine	HT115	6.7
Large intestine	HT29	6.4
Large intestine	HT55	6.1
Large intestine	KM12	6.3
Large intestine	LOVO	5.8
Large intestine	LS1034	6.5
Large intestine	LS123	6.6
Large intestine	LS180	6.2
Large intestine	LS411N	5.8
Large intestine	LS513	6.3
Large intestine	MDST8	6.1
Large intestine	NCIH508	6.1
Large intestine	NCIH716	6.2
Large intestine	NCIH747	6.2
Large intestine	OUMS23	6.2
Large intestine	RCM1	6.2
Large intestine	RKO	7
Large intestine	SKCO1	6.2
Large intestine	SNU1040	6.5
Large intestine	SNU1197	6
Large intestine	SNU175	6.6
Large intestine	SNU283	6.4
Large intestine	SNU407	6.5
Large intestine	SNU503	6.2
Large intestine	SNU61	6.6
Large intestine	SNU81	6.4
Large intestine	SNUC1	6.7
Large intestine	SNUC2A	6.3
Large intestine	SNUC4	6.6
Large intestine	SNUC5	6.4
Large intestine	SW1116	6.3
Large intestine	SW1417	6
Large intestine	SW1463	6.6
Large intestine	SW403	5.9
Large intestine	SW480	5.5
Large intestine	SW48	6.3
Large intestine	SW620	6.1
Large intestine	SW837	5.9
Large intestine	SW948	6
Large intestine	T84	7.1
Liver	ALEXANDERCELLS	6.8
Liver	C3A	6.4
Liver	HEP3B217	7.2
Liver	HEPG2	6.4
Liver	HLE	6.7
Liver	HLF	6.4
Liver	HUH1	6.2
Liver	HUH6	6.3
Liver	HUH7	6.7
Liver	JHH1	5.4
Liver	JHH2	6
Liver	JHH4	5.8
Liver	JHH5	6.6
Liver	JHH6	6
Liver	JHH7	6.7
Liver	LI7	6.2
Liver	PLCPRF5	6.4
Liver	SKHEP1	6
Liver	SNU182	5.8
Liver	SNU387	6.1
Liver	SNU398	6.6
Liver	SNU423	6.6
Liver	SNU449	6
Liver	SNU475	6
Liver	SNU761	6.9
Liver	SNU878	6.3
Liver	SNU886	6.4
Lung	A549	5.9
Lung	ABC1	6.4
Lung	BEN	6.6
Lung	CAL12T	5.7
Lung	CALU1	6.5
Lung	CALU3	5.6
Lung	CALU6	6.2
Lung	CHAGOK1	6.3
Lung	COLO668	6.5
Lung	COLO699	6.9
Lung	CORL105	6.2
Lung	CORL23	6.5
Lung	CORL24	6.7
Lung	CORL279	7.3
Lung	CORL311	6.3
Lung	CORL47	6.9
Lung	CORL51	6.9
Lung	CORL88	6.8
Lung	CORL95	6.5
Lung	CPCN	7.3
Lung	DMS114	5.9
Lung	DMS153	6
Lung	DMS273	6.6
Lung	DMS454	6.2
Lung	DMS53	6.2
Lung	DMS79	6
Lung	DV90	6.4
Lung	EBC1	6.4
Lung	EPLC272H	6.6
Lung	HARA	6.6
Lung	HCC1171	5.7
Lung	HCC1195	6
Lung	HCC15	6
Lung	HCC2279	6.8
Lung	HCC2935	6
Lung	HCC33	6.3
Lung	HCC366	6.3
Lung	HCC4006	5.8
Lung	HCC44	6.4
Lung	HCC78	6.5
Lung	HCC827	6.3
Lung	HCC95	6.2
Lung	HLC1	6.4
Lung	HLFA	5.6
Lung	HS229T	6.1
Lung	HS618T	6
Lung	IALM	5.5
Lung	KNS62	6
Lung	LC1F	6.1
Lung	LC1SQSF	5.9
Lung	LCLC103H	5.5
Lung	LCLC97TM1	6.5
Lung	LK2	6.5
Lung	LOUNH91	5.9
Lung	LU65	6.5
Lung	LU99	6.1
Lung	LUDLU1	5.6
Lung	LXF289	6.2
Lung	MORCPR	6.4
Lung	NCIH1048	6.3
Lung	NCIH1092	6.6
Lung	NCIH1105	6.6
Lung	NCIH1155	6.3
Lung	NCIH1184	6.1
Lung	NCIH1299	6.5
Lung	NCIH1339	6.2
Lung	NCIH1341	6.3
Lung	NCIH1355	6.3
Lung	NCIH1373	6.1
Lung	NCIH1385	6.4
Lung	NCIH1395	6.1
Lung	NCIH1435	6.3
Lung	NCIH1436	6.5
Lung	NCIH1437	6.5
Lung	NCIH146	6.1
Lung	NCIH1563	5.7
Lung	NCIH1568	6.6
Lung	NCIH1573	6
Lung	NCIH1581	6.5
Lung	NCIH1618	6.6
Lung	NCIH1623	6.4
Lung	NCIH1648	5.8
Lung	NCIH1650	5.6
Lung	NCIH1651	5.9
Lung	NCIH1666	5.3
Lung	NCIH1693	5.8
Lung	NCIH1694	6.2
Lung	NCIH1703	6.2
Lung	NCIH1734	6
Lung	NCIH1755	5.8
Lung	NCIH1781	6.3
Lung	NCIH1792	6.3
Lung	NCIH1793	5.9
Lung	NCIH1836	6.9
Lung	NCIH1838	6.4
Lung	NCIH1869	6
Lung	NCIH1876	6.5
Lung	NCIH1915	6.2
Lung	NCIH1930	5.9
Lung	NCIH1944	5.8
Lung	NCIH1963	6.3
Lung	NCIH196	5.8
Lung	NCIH1975	6.1
Lung	NCIH2009	6.3
Lung	NCIH2023	6
Lung	NCIH2029	6.7
Lung	NCIH2030	6.2
Lung	NCIH2066	6.3
Lung	NCIH2081	6.4
Lung	NCIH2085	5.7
Lung	NCIH2087	6.1
Lung	NCIH209	6.5
Lung	NCIH2106	7.1
Lung	NCIH2110	6.4
Lung	NCIH211	6.7
Lung	NCIH2122	6.1
Lung	NCIH2126	6.1
Lung	NCIH2141	7.2
Lung	NCIH2170	6.3
Lung	NCIH2171	6.4
Lung	NCIH2172	6.4
Lung	NCIH2196	6.7
Lung	NCIH2227	6.5
Lung	NCIH2228	5.8
Lung	NCIH226	5.8
Lung	NCIH2286	6.5
Lung	NCIH2291	6.3
Lung	NCIH2342	6.7
Lung	NCIH2347	5.9
Lung	NCIH23	6.2
Lung	NCIH2405	5.4
Lung	NCIH2444	5.4
Lung	NCIH292	5.9
Lung	NCIH322	6.5
Lung	NCIH3255	6.3
Lung	NCIH358	6.3
Lung	NCIH441	6.2
Lung	NCIH446	7.2
Lung	NCIH460	6.3
Lung	NCIH510	5.5
Lung	NCIH520	7.3
Lung	NCIH522	6.1
Lung	NCIH524	6.4
Lung	NCIH526	6.4
Lung	NCIH596	6
Lung	NCIH647	5.8
Lung	NCIH650	6
Lung	NCIH661	6.2
Lung	NCIH69	6.4
Lung	NCIH727	6.3
Lung	NCIH810	6.3
Lung	NCIH82	6.4
Lung	NCIH838	5.9
Lung	NCIH841	6
Lung	NCIH854	7
Lung	NCIH889	6.4
Lung	PC14	5.7
Lung	RERFLCAD1	5.8
Lung	RERFLCAD2	6
Lung	RERFLCAI	5.9
Lung	RERFLCKJ	5.6
Lung	RERFLCMS	5.9
Lung	RERFLCSQ1	5.7
Lung	SBC5	5.9
Lung	SCLC21H	7
Lung	SHP77	6.1
Lung	SKLU1	6.6
Lung	SKMES1	5.5
Lung	SQ1	6.3
Lung	SW1271	6.2
Lung	SW1573	6.3
Lung	SW900	6.3
Lung	VMRCLCD	6.9
Lung	VMRCLCP	6
Oesophagus	COLO680N	5.8
Oesophagus	ECGI10	6.2
Oesophagus	KYSE140	6.4
Oesophagus	KYSE150	6.3
Oesophagus	KYSE180	6.8
Oesophagus	KYSE270	6.1
Oesophagus	KYSE30	6
Oesophagus	KYSE410	6.1
Oesophagus	KYSE450	6
Oesophagus	KYSE510	6.3
Oesophagus	KYSE520	5
Oesophagus	KYSE70	6
Oesophagus	OE19	7.2
Oesophagus	OE33	5.9
Oesophagus	TE10	6.5
Oesophagus	TE11	6
Oesophagus	TE14	6.2
Oesophagus	TE15	5.9
Oesophagus	TE1	5.9
Oesophagus	TE4	6.5
Oesophagus	TE5	5.8
Oesophagus	TE6	6.1
Oesophagus	TE8	6.4
Oesophagus	TE9	6
Oesophagus	TT	5.9
Ovary	59M	6.2
Ovary	A2780	6.6
Ovary	CAOV3	5.7
Ovary	CAOV4	5
Ovary	COLO704	6.9
Ovary	COV318	6
Ovary	COV362	6
Ovary	COV434	6.5
Ovary	COV504	5.5
Ovary	COV644	6.1
Ovary	EFO21	6.3
Ovary	EFO27	5.9
Ovary	ES2	6.1
Ovary	FUOV1	6.1
Ovary	HEYA8	5.9
Ovary	HS571T	5.7
Ovary	IGROV1	6.6
Ovary	JHOC5	5.8
Ovary	JHOM1	5.8
Ovary	JHOM2B	6.2
Ovary	JHOS2	5.6
Ovary	JHOS4	5.3
Ovary	KURAMOCHI	6.1
Ovary	MCAS	5.9
Ovary	NIHOVCAR3	5.8
Ovary	OAW28	6.2
Ovary	OAW42	6.1
Ovary	OC314	5.8
Ovary	OC316	5.8
Ovary	ONCODG1	5.9
Ovary	OV56	5.9
Ovary	OV7	6.1
Ovary	OV90	6.5
Ovary	OVCAR4	6
Ovary	OVCAR8	6
Ovary	OVISE	5.9
Ovary	OVK18	6.5
Ovary	OVKATE	5.5
Ovary	OVMANA	5.9
Ovary	OVSAHO	5.3
Ovary	OVTOKO	6.5
Ovary	RMGI	6.5
Ovary	RMUGS	5.1
Ovary	SKOV3	6.3
Ovary	SNU119	5.9
Ovary	SNU840	5.6
Ovary	SNU8	5.6
Ovary	TOV112D	6.5
Ovary	TOV21G	6
Ovary	TYKNU	6.4
Pancreas	ASPC1	5.7
Pancreas	BXPC3	5.9
Pancreas	CAPAN1	6.1
Pancreas	CAPAN2	6
Pancreas	CFPAC1	5.9
Pancreas	DANG	6
Pancreas	HPAC	6.3
Pancreas	HPAFII	6.3
Pancreas	HS766T	5.9
Pancreas	HUPT3	6.4
Pancreas	HUPT4	6.2
Pancreas	KCIMOH1	5.6
Pancreas	KLM1	5.6
Pancreas	KP2	5.9
Pancreas	KP3	5.9
Pancreas	KP4	5.9
Pancreas	L33	6.2
Pancreas	MIAPACA2	6.8
Pancreas	PANC0203	6.2
Pancreas	PANC0213	6.3
Pancreas	PANC0327	6.2
Pancreas	PANC0403	6
Pancreas	PANC0504	6.1
Pancreas	PANC0813	6.1
Pancreas	PANC1005	6.2
Pancreas	PANC1	6
Pancreas	PATU8902	5.7
Pancreas	PATU8988S	5.5
Pancreas	PATU8988T	5.9
Pancreas	PK1	6
Pancreas	PK45H	6.3
Pancreas	PK59	5.9
Pancreas	PL45	6.2
Pancreas	PSN1	6.6
Pancreas	QGP1	6.3
Pancreas	SNU213	6.2
Pancreas	SNU324	6.7
Pancreas	SNU410	6
Pancreas	SU8686	5.7
Pancreas	SUIT2	6.2
Pancreas	SW1990	5.8
Pancreas	T3M4	6.6
Pancreas	TCCPAN2	5.7
Pancreas	YAPC	5.9
Pleura	ACCMESO1	5.7
Pleura	DM3	6.1
Pleura	ISTMES1	6
Pleura	ISTMES2	6.2
Pleura	JL1	5.8
Pleura	MPP89	6.1
Pleura	MSTO211H	6.1
Pleura	NCIH2052	5.8
Pleura	NCIH2452	6
Pleura	NCIH28	5.8
Prostate	22RV1	6.4
Prostate	DU145	5.9
Prostate	LNCAPCLONEFGC	6.4
Prostate	MDAPCA2B	6.6
Prostate	NCIH660	6.6
Prostate	PC3	6.1
Prostate	VCAP	6.3
Salivary gland	A253	6.4
Salivary gland	YD15	5.8
Skin	A101D	6
Skin	A2058	6.8
Skin	A375	6.3
Skin	C32	6.2
Skin	CHL1	6.1
Skin	CJM	6
Skin	COLO679	6.2
Skin	COLO741	6.5
Skin	COLO783	6.2
Skin	COLO792	6.3
Skin	COLO800	6.6
Skin	COLO818	6.3
Skin	COLO829	6.9
Skin	COLO849	7.1
Skin	G361	6.2
Skin	GRM	6.9
Skin	HMCB	6.1
Skin	HS294T	6.3
Skin	HS600T	5.8
Skin	HS688AT	5.9
Skin	HS695T	5.9
Skin	HS839T	6
Skin	HS852T	6.4
Skin	HS895T	6
Skin	HS934T	6.1
Skin	HS936T	6.7
Skin	HS939T	6.1
Skin	HS940T	6.2
Skin	HS944T	6.3
Skin	HT144	6.4
Skin	IGR1	5.8
Skin	IGR37	6.3
Skin	IGR39	6.6
Skin	IPC298	6.3
Skin	K029AX	6.3
Skin	LOXIMVI	6.4
Skin	MALME3M	5.8
Skin	MDAMB435S	5.8
Skin	MELHO	6.2
Skin	MELJUSO	6.9
Skin	MEWO	6.1
Skin	RPMI7951	6.1
Skin	RVH421	6.1
Skin	SH4	6.6
Skin	SKMEL1	6.9
Skin	SKMEL24	6.1
Skin	SKMEL28	6.3
Skin	SKMEL2	6
Skin	SKMEL30	6.2
Skin	SKMEL31	6.5
Skin	SKMEL3	6.2
Skin	SKMEL5	6.2
Skin	UACC257	6.6
Skin	UACC62	6.7
Skin	WM115	6.1
Skin	WM1799	6.2
Skin	WM2664	6.8
Skin	WM793	6.3
Skin	WM88	5.9
Skin	WM983B	6.2
Small intestine	HUTU80	6.6
Soft tissue	A204	6.4
Soft tissue	G401	6.3
Soft tissue	G402	6.3
Soft tissue	GCT	6.1
Soft tissue	HS729	6.1
Soft tissue	HT1080	6.1
Soft tissue	KYM1	7.2
Soft tissue	MESSA	6.2
Soft tissue	RD	6.5
Soft tissue	RH30	6.8
Soft tissue	RH41	6.4
Soft tissue	RKN	5.6
Soft tissue	S117	6.2
Soft tissue	SJRH30	6.9
Soft tissue	SKLMS1	5.9
Soft tissue	SKUT1	5.8
Soft tissue	TE125T	6.1
Soft tissue	TE159T	6.6
Soft tissue	TE441T	6.7
Soft tissue	TE617T	6.4
Stomach	2313287	6.3
Stomach	AGS	6.3
Stomach	AZ521	6.6
Stomach	ECC10	6.8
Stomach	ECC12	6.2
Stomach	FU97	6.3
Stomach	GCIY	5.3
Stomach	GSS	6.2
Stomach	GSU	6.3
Stomach	HGC27	6.4
Stomach	HS746T	6.1
Stomach	HUG1N	6.3
Stomach	IM95	6.5
Stomach	KATOIII	6.3
Stomach	KE39	5.7
Stomach	LMSU	7.2
Stomach	MKN1	5.5
Stomach	MKN45	6.3
Stomach	MKN74	5.9
Stomach	MKN7	6
Stomach	NCCSTCK140	7.2
Stomach	NCIN87	6.2
Stomach	NUGC2	5.9
Stomach	NUGC3	6.3
Stomach	NUGC4	6.1
Stomach	OCUM1	6.5
Stomach	RERFGC1B	5.9
Stomach	SH10TC	5.7
Stomach	SNU16	6.5
Stomach	SNU1	6.3
Stomach	SNU216	6
Stomach	SNU520	6.6
Stomach	SNU5	6.9
Stomach	SNU601	6.8
Stomach	SNU620	6.4
Stomach	SNU668	6.2
Stomach	SNU719	6.7
Stomach	TGBC11TKB	6.5
Thyroid	8305C	5.4
Thyroid	8505C	6.1
Thyroid	BCPAP	5.7
Thyroid	BHT101	6.2
Thyroid	CAL62	6.3
Thyroid	CGTHW1	6.1
Thyroid	FTC133	6.2
Thyroid	FTC238	6.3
Thyroid	ML1	5.2
Thyroid	SW579	6.5
Thyroid	TT2609C02	6
Thyroid	TT	6.3
Upper aerodigestive tract	BHY	6
Upper aerodigestive tract	BICR16	6.3
Upper aerodigestive tract	BICR18	5.9
Upper aerodigestive tract	BICR22	6.2
Upper aerodigestive tract	BICR31	6.3
Upper aerodigestive tract	BICR56	5.7
Upper aerodigestive tract	BICR6	5.9
Upper aerodigestive tract	CAL27	6
Upper aerodigestive tract	CAL33	6.4
Upper aerodigestive tract	DETROIT562	6
Upper aerodigestive tract	FADU	5.6
Upper aerodigestive tract	HS840T	5.9
Upper aerodigestive tract	HSC2	5.8
Upper aerodigestive tract	HSC3	5.8
Upper aerodigestive tract	HSC4	5.8
Upper aerodigestive tract	PECAPJ15	6
Upper aerodigestive tract	PECAPJ34CLONEC12	6
Upper aerodigestive tract	PECAPJ41CLONED2	5.5
Upper aerodigestive tract	PECAPJ49	6.2
Upper aerodigestive tract	SCC15	6
Upper aerodigestive tract	SCC25	5.8
Upper aerodigestive tract	SCC4	6.1
Upper aerodigestive tract	SCC9	6.3
Upper aerodigestive tract	SNU1076	5.8
Upper aerodigestive tract	SNU1214	5.5
Upper aerodigestive tract	SNU46	6.6
Upper aerodigestive tract	SNU899	6.1
Upper aerodigestive tract	YD10B	6.2
Upper aerodigestive tract	YD38	6.3
Upper aerodigestive tract	YD8	6.2
Urinary tract	5637	6.4
Urinary tract	639V	6.2
Urinary tract	647V	5.9
Urinary tract	BC3C	5.9
Urinary tract	BFTC905	6
Urinary tract	CAL29	6.1
Urinary tract	HS172T	5.7
Urinary tract	HT1197	6.5
Urinary tract	HT1376	6.2
Urinary tract	J82	6.6
Urinary tract	JMSU1	7.2
Urinary tract	KMBC2	6
Urinary tract	KU1919	6
Urinary tract	RT11284	6.3
Urinary tract	RT112	6.2
Urinary tract	RT4	5.9
Urinary tract	SCABER	6
Urinary tract	SW1710	5.9
Urinary tract	SW780	6.2
Urinary tract	T24	6
Urinary tract	TCCSUP	6.5
Urinary tract	UMUC1	6.3
Urinary tract	UMUC3	6.2
Urinary tract	VMCUB1	6.1

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	7.6
Adrenal gland	10
Appendix	14.5
Bone marrow	14
Breast	2.3
Cerebral cortex	10
Cervix, uterine	2.9
Colon	5.8
Duodenum	13.2
Endometrium	6.6
Epididymis	1.4
Esophagus	6.9
Fallopian tube	4.2
Gallbladder	8.3
Heart muscle	1.9
Kidney	4.2
Liver	2
Lung	10
Lymph node	9.7
Ovary	4.3
Pancreas	2.1
Parathyroid gland	4.2
Placenta	7.9
Prostate	4.1
Rectum	4.5
Salivary gland	2.4
Seminal vesicle	3
Skeletal muscle	3.5
Skin	10.9
Small intestine	14
Smooth muscle	4.9
Spleen	12.9
Stomach	12.1
Testis	92.5
Thyroid gland	5.3
Tonsil	4.8
Urinary bladder	5

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
28529740	Overexpression (copy number gain)	Pancreatic Carcinoma	In total, 10/225 carcinoma cases (4.4%) analyzed by immunohistochemistry demonstrated intense nuclear protein expression of DOT1L and in 9/224 tumors analyzed using FISH (4.0%), copy-number variations (CNV) were detectable. No DOT1L amplification was detected in the carcinoma cohort.
28209620	Overexpression	Neuroblastoma	In addition, high levels of DOT1L gene expression in human neuroblastoma tissues correlated with high levels of MYCN, ODC1, and E2F2 gene expression and independently correlated with poor patient survival.
28114995	Overexpression	Ovarian Neoplasm	DOT1L expression and H3K79 methylation was significantly increased in malignant ovarian tumors.
26783998	Overexpression	Malignant Breast Neoplasm	The expression of DOT1L was up-regulated in malignant breast cancer tissues.
26199140	altered expression	Breast Carcinoma	Clinically, DOT1L expression is associated with poorer survival and aggressiveness of breast cancers.
26045981	Overexpression	Esophageal Squamous Cell Carcinoma	Higher expression of enzymes regulating methylation (DOT1L and PRMT1) and acetylation (KAT7, KAT8, KAT2A and KAT6A) of histone was found associated with ESCC risk.
24816405	Overexpression	Colorectal Carcinoma	Furthermore, high DOT1L expression and H3K79me2 in colorectal cancer tissues was a predictor of poor patient survival.
23998575	Underexpression	Acute Monocytic Leukemia	The results indicated that the expression of DOT1L was statistically lower than that in the control groups.
20230194	Underexpression	Leukemia	Studies from stem cells and certain leukemias suggest a second mechanism of leukemogenesis, in which reduced or mistargeted DOT1L activity yields altered centromeric chromatin and consequent chromosomal instability.

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.413	4.07e-18	34.9	51	14.1	Loss
BRCA	Breast invasive carcinoma	1075	0.314	5.83e-26	32.9	55.8	11.3	Neutral
CESC	Cervical and endocervical cancers	292	0.591	6.72e-29	33.2	54.5	12.3	Neutral
COAD	Colon adenocarcinoma	449	0.249	8.98e-08	13.1	71.3	15.6	Neutral
ESCA	Esophageal carcinoma	183	0.453	1.18e-10	51.4	39.9	8.7	Loss
GBM	Glioblastoma multiforme	147	0.35	1.35e-05	8.2	55.1	36.7	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.485	1.04e-31	31.9	60.3	7.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.076	0.0807	3.6	87.4	9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.296	3.12e-07	7.6	91	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.244	0.00154	3.6	94	2.4	Neutral
LGG	Brain Lower Grade Glioma	513	0.221	4.16e-07	4.3	72.9	22.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.387	1.94e-14	23.9	62.1	14	Neutral
LUAD	Lung adenocarcinoma	512	0.238	5.04e-08	53.5	41.8	4.7	Loss
LUSC	Lung squamous cell carcinoma	498	0.399	1.78e-20	45.2	39	15.9	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.447	3.54e-16	88.7	7.7	3.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.188	0.0124	19.8	74	6.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.221	0.00472	0.6	84.6	14.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.191	2.05e-05	8.4	90.2	1.4	Neutral
READ	Rectum adenocarcinoma	164	0.266	0.000567	20.7	60.4	18.9	Neutral
SARC	Sarcoma	255	0.439	1.97e-13	20.8	45.9	33.3	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.393	4.9e-15	27	58.3	14.7	Neutral
STAD	Stomach adenocarcinoma	413	0.235	1.32e-06	37	55.7	7.3	Loss
TGCT	Testicular Germ Cell Tumors	150	0.419	9.4e-08	32	44	24	Neutral
THCA	Thyroid carcinoma	497	0.14	0.00177	1.4	97.2	1.4	Neutral
THYM	Thymoma	119	0.324	0.000329	2.5	94.1	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.485	5.49e-33	27.4	69.3	3.4	Neutral

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.293	8.7e-10	17	408	-0.009	0.106	NS/NA
BRCA	Breast invasive carcinoma	-0.149	1.03e-05	83	785	-0.015	0.0228	NS/NA
CESC	Cervical and endocervical cancers	-0.384	3.56e-12	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.147	0.00882	19	297	0.002	0.851	NS/NA
ESCA	Esophageal carcinoma	-0.237	0.000889	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.171	0.172	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.242	1.25e-08	20	522	-0.013	0.0481	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.04	0.456	24	319	0.001	9.55e-06	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.107	0.0647	23	275	0.001	0.328	NS/NA
LAML	Acute Myeloid Leukemia	-0.106	0.169	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.045	0.306	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.271	2.36e-08	41	373	0.006	0.00302	NS/NA
LUAD	Lung adenocarcinoma	-0.126	0.00581	21	456	0	0.41	NS/NA
LUSC	Lung squamous cell carcinoma	-0.156	0.0023	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.833	0.00827	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.182	0.014	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.014	0.846	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.066	0.125	35	498	-0.007	0.467	NS/NA
READ	Rectum adenocarcinoma	-0.263	0.00808	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.326	7.18e-08	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.244	8.93e-08	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.201	9.62e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.455	3.69e-09	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	0.012	0.786	50	509	0.001	0.967	NS/NA
THYM	Thymoma	-0.179	0.0484	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.317	3.24e-12	34	431	0.003	0.00248	NS/NA

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0745	NS	24476821
BRCA	Breast invasive carcinoma	521	4.71e-10	Significant	23000897
COAD	Colon adenocarcinoma	149	0.18	NS	22810696
GBM	Glioblastoma multiforme	157	5.06e-10	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	7.89e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	2.15e-07	Significant	26536169
LGG	Brain Lower Grade Glioma	513	0.0692	NS	26824661
LUAD	Lung adenocarcinoma	230	0.784	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0973	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0175	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.046	Significant	26544944
READ	Rectum adenocarcinoma	67	0.954	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00349	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.0053	Significant	25079317
THCA	Thyroid carcinoma	391	0.5	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	4.65e-08	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.89	0.576	NS
BRCA	Breast invasive carcinoma	1079	1.425	0.119	NS
CESC	Cervical and endocervical cancers	291	0.87	0.687	NS
COAD	Colon adenocarcinoma	439	0.874	0.636	NS
ESCA	Esophageal carcinoma	184	0.579	0.0988	NS
GBM	Glioblastoma multiforme	158	0.794	0.366	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.567	0.00244	Longer
KIRC	Kidney renal clear cell carcinoma	531	2.112	0.000266	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.614	0.286	NS
LAML	Acute Myeloid Leukemia	149	1.149	0.658	NS
LGG	Brain Lower Grade Glioma	511	1.331	0.26	NS
LIHC	Liver hepatocellular carcinoma	365	1.462	0.116	NS
LUAD	Lung adenocarcinoma	502	1.012	0.958	NS
LUSC	Lung squamous cell carcinoma	494	0.729	0.0973	NS
OV	Ovarian serous cystadenocarcinoma	303	1.283	0.238	NS
PAAD	Pancreatic adenocarcinoma	177	0.581	0.0482	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	634051239.854	0.144	NS
PRAD	Prostate adenocarcinoma	497	558256167.17	0.0309	Shorter
READ	Rectum adenocarcinoma	159	0.578	0.351	NS
SARC	Sarcoma	259	1.565	0.0995	NS
SKCM	Skin Cutaneous Melanoma	459	1.451	0.0439	Shorter
STAD	Stomach adenocarcinoma	388	0.633	0.036	Longer
TGCT	Testicular Germ Cell Tumors	134	0	0.317	NS
THCA	Thyroid carcinoma	500	1.526	0.578	NS
THYM	Thymoma	119	0	0.0119	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.498	0.0238	Longer

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.131	0.00801	Lower
BRCA	Breast invasive carcinoma	1071	0.04	0.189	NS
CESC	Cervical and endocervical cancers	167	0.165	0.033	Higher
COAD	Colon adenocarcinoma	445	-0.069	0.147	NS
ESCA	Esophageal carcinoma	162	-0.178	0.0231	Lower
HNSC	Head and Neck squamous cell carcinoma	448	-0.065	0.169	NS
KIRC	Kidney renal clear cell carcinoma	531	0.017	0.692	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.158	0.0106	Lower
LIHC	Liver hepatocellular carcinoma	347	0.056	0.297	NS
LUAD	Lung adenocarcinoma	507	0.035	0.426	NS
LUSC	Lung squamous cell carcinoma	497	-0.011	0.806	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.145	0.0116	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.123	0.105	NS
READ	Rectum adenocarcinoma	156	-0.185	0.0208	Lower
SKCM	Skin Cutaneous Melanoma	410	-0.045	0.359	NS
STAD	Stomach adenocarcinoma	392	-0.077	0.128	NS
TGCT	Testicular Germ Cell Tumors	81	-0.272	0.014	Lower
THCA	Thyroid carcinoma	499	-0.076	0.092	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.102	0.0225	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.158	0.00905	Lower
HNSC	Head and Neck squamous cell carcinoma	498	-0.064	0.152	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.022	0.607	NS
LGG	Brain Lower Grade Glioma	514	0.105	0.0169	Higher
LIHC	Liver hepatocellular carcinoma	366	0.082	0.119	NS
OV	Ovarian serous cystadenocarcinoma	296	0.041	0.485	NS
PAAD	Pancreatic adenocarcinoma	176	-0.049	0.518	NS
STAD	Stomach adenocarcinoma	406	-0.092	0.0651	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.09	0.0374	Lower

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for DOT1L.

Summary
Symbol	DOT1L
Name	DOT1 like histone lysine methyltransferase
Aliases	KIAA1814; DOT1; KMT4; histone methyltransferase DOT1L; DOT1-like, histone H3 methyltransferase (S. cerevisia ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
28209620	Neuroblastoma	partner	MYCN; ODC1; E2F2	Positive correlation	In addition, high levels of DOT1L gene expression in human neuroblastoma tissues correlated with high levels of MYCN, ODC1, and E2F2 gene expression and independently correlated with poor patient survival.
28114995	Ovarian Neoplasm	downstream	CDK6; CCND3	regulation	Furthermore, DOT1L regulates the transcription of G1 phase genes CDK6 and CCND3 through H3K79 dimethylation; therefore, blocking DOT1L could result in G1 arrest and thereby impede the cell proliferation in vitro and tumor growth in vivo.
27683039	Hyperdiploid B Acute Lymphoblastic Leukemia	partner	FLT3	Co-existing mutation	Mutations in FLT3 significantly co-occurred with DOT1L (p=0.04), suggesting functional cooperation in leukemogenesis.
27683039	Leukemia	partner	FLT3	Collaboration	Mutations in FLT3 significantly co-occurred with DOT1L (p=0.04), suggesting functional cooperation in leukemogenesis.
26199140	Breast Carcinoma	partner	c-Myc-p300 complex; SNAIL	Collaboration; binding	DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex and facilitates lysine-79 methylation and acetylation towards histone H3, leading to the dissociation of HDAC1 and DNMT1 in the regions.
26199140	Breast Carcinoma	downstream	HDAC1; DNMT1	Negative regulation	DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex and facilitates lysine-79 methylation and acetylation towards histone H3, leading to the dissociation of HDAC1 and DNMT1 in the regions.