CR2Cancer

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

Function

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone phosphorylation	H2AXT142	#	19234442

> Gene Ontology [ TOP ]
Biological Process	GO:0000132 establishment of mitotic spindle orientation GO:0000226 microtubule cytoskeleton organization GO:0001501 skeletal system development GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001708 cell fate specification GO:0001710 mesodermal cell fate commitment GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001823 mesonephros development GO:0003007 heart morphogenesis GO:0003151 outflow tract morphogenesis GO:0003156 regulation of animal organ formation GO:0003263 cardioblast proliferation GO:0003264 regulation of cardioblast proliferation GO:0003266 regulation of secondary heart field cardioblast proliferation GO:0006282 regulation of DNA repair GO:0006302 double-strand break repair GO:0006470 protein dephosphorylation GO:0007163 establishment or maintenance of cell polarity GO:0007219 Notch signaling pathway GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007498 mesoderm development GO:0007501 mesodermal cell fate specification GO:0007507 heart development GO:0007605 sensory perception of sound GO:0008593 regulation of Notch signaling pathway GO:0009314 response to radiation GO:0010212 response to ionizing radiation GO:0014706 striated muscle tissue development GO:0016311 dephosphorylation GO:0016570 histone modification GO:0016576 histone dephosphorylation GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0030010 establishment of cell polarity GO:0030323 respiratory tube development GO:0030324 lung development GO:0035088 establishment or maintenance of apical/basal cell polarity GO:0035239 tube morphogenesis GO:0035335 peptidyl-tyrosine dephosphorylation GO:0035904 aorta development GO:0035909 aorta morphogenesis GO:0038034 signal transduction in absence of ligand GO:0040001 establishment of mitotic spindle localization GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042473 outer ear morphogenesis GO:0042474 middle ear morphogenesis GO:0043583 ear development GO:0045165 cell fate commitment GO:0045739 positive regulation of DNA repair GO:0045747 positive regulation of Notch signaling pathway GO:0048332 mesoderm morphogenesis GO:0048333 mesodermal cell differentiation GO:0048514 blood vessel morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048645 animal organ formation GO:0048663 neuron fate commitment GO:0048665 neuron fate specification GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048752 semicircular canal morphogenesis GO:0048754 branching morphogenesis of an epithelial tube GO:0048839 inner ear development GO:0048844 artery morphogenesis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050954 sensory perception of mechanical stimulus GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051293 establishment of spindle localization GO:0051294 establishment of spindle orientation GO:0051640 organelle localization GO:0051653 spindle localization GO:0051656 establishment of organelle localization GO:0060037 pharyngeal system development GO:0060428 lung epithelium development GO:0060479 lung cell differentiation GO:0060487 lung epithelial cell differentiation GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060562 epithelial tube morphogenesis GO:0060675 ureteric bud morphogenesis GO:0060795 cell fate commitment involved in formation of primary germ layer GO:0060840 artery development GO:0060872 semicircular canal development GO:0060914 heart formation GO:0060993 kidney morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061245 establishment or maintenance of bipolar cell polarity GO:0061323 cell proliferation involved in heart morphogenesis GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0071599 otic vesicle development GO:0071600 otic vesicle morphogenesis GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072073 kidney epithelium development GO:0072078 nephron tubule morphogenesis GO:0072080 nephron tubule development GO:0072088 nephron epithelium morphogenesis GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0072513 positive regulation of secondary heart field cardioblast proliferation GO:0090102 cochlea development GO:0090103 cochlea morphogenesis GO:0090596 sensory organ morphogenesis GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:1901099 negative regulation of signal transduction in absence of ligand GO:2000027 regulation of organ morphogenesis GO:2000136 regulation of cell proliferation involved in heart morphogenesis GO:2000826 regulation of heart morphogenesis GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Molecular Function	GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity
Cellular Component	GO:0032993 protein-DNA complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4414619	c.1011C>T	p.H337H	Substitution - coding silent	Kidney
COSM606193	c.1632G>T	p.R544S	Substitution - Missense	Stomach
COSM1673965	c.981G>A	p.W327*	Substitution - Nonsense	Large_intestine
COSM3925554	c.413C>T	p.S138L	Substitution - Missense	Skin
COSM454820	c.208G>A	p.G70R	Substitution - Missense	Breast
COSM3925558	c.227C>T	p.P76L	Substitution - Missense	Skin
COSM4461875	c.1224C>T	p.G408G	Substitution - coding silent	Skin
COSM70664	c.116G>A	p.G39D	Substitution - Missense	Ovary
COSM4151856	c.966+5G>C	p.?	Unknown	Ovary
COSM393842	c.512G>T	p.S171I	Substitution - Missense	Lung
COSM4151858	c.807A>C	p.A269A	Substitution - coding silent	Ovary
COSM4839080	c.1624A>C	p.I542L	Substitution - Missense	Cervix
COSM4437378	c.1090G>T	p.E364*	Substitution - Nonsense	Oesophagus
COSM4924872	c.450T>A	p.G150G	Substitution - coding silent	Liver
COSM1700244	c.485G>A	p.G162E	Substitution - Missense	Skin
COSM226200	c.752C>T	p.S251F	Substitution - Missense	Soft_tissue
COSM3650718	c.1228C>T	p.P410S	Substitution - Missense	Skin
COSM3901368	c.1602A>C	p.K534N	Substitution - Missense	Stomach
COSM1292732	c.363T>C	p.A121A	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM6013184	c.1743G>A	p.M581I	Substitution - Missense	Skin
COSM3650707	c.1564C>G	p.P522A	Substitution - Missense	Skin
COSM5721211	c.1678G>A	p.E560K	Substitution - Missense	Skin
COSM4138731	c.992A>G	p.E331G	Substitution - Missense	Kidney
COSM4943347	c.210G>A	p.G70G	Substitution - coding silent	Liver
COSM364789	c.851C>A	p.S284*	Substitution - Nonsense	Lung
COSM244329	c.1702G>A	p.A568T	Substitution - Missense	Large_intestine
COSM4511111	c.858C>T	p.P286P	Substitution - coding silent	Skin
COSM5567893	c.800G>A	p.S267N	Substitution - Missense	Prostate
COSM3901376	c.1386A>C	p.E462D	Substitution - Missense	Stomach
COSM3834983	c.1461G>A	p.S487S	Substitution - coding silent	Breast
COSM4985350	c.58C>G	p.P20A	Substitution - Missense	Soft_tissue
COSM5428988	c.1038C>G	p.N346K	Substitution - Missense	Oesophagus
COSM3901392	c.192C>A	p.F64L	Substitution - Missense	Stomach
COSM1458098	c.1443G>A	p.L481L	Substitution - coding silent	Large_intestine
COSM3925556	c.410C>T	p.S137F	Substitution - Missense	Skin
COSM3925545	c.812C>G	p.T271R	Substitution - Missense	Skin
COSM137499	c.725G>A	p.S242N	Substitution - Missense	Skin
COSM3650743	c.176G>A	p.G59E	Substitution - Missense	Skin
COSM750788	c.1310G>C	p.R437P	Substitution - Missense	Lung
COSM4805713	c.1318C>A	p.R440R	Substitution - coding silent	Liver
COSM3650705	c.1605A>T	p.E535D	Substitution - Missense	Skin
COSM5711007	c.862A>G	p.K288E	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM2874971	c.174C>T	p.D58D	Substitution - coding silent	Large_intestine
COSM5793952	c.82T>A	p.S28T	Substitution - Missense	Breast
COSM3925550	c.739C>A	p.P247T	Substitution - Missense	Skin
COSM4903134	c.903G>A	p.G301G	Substitution - coding silent	Skin
COSM1458104	c.1032C>T	p.Y344Y	Substitution - coding silent	Prostate
COSM5895947	c.592G>A	p.G198R	Substitution - Missense	Skin
COSM4400675	c.1409A>C	p.E470A	Substitution - Missense	Skin
COSM3925560	c.52G>A	p.E18K	Substitution - Missense	Skin
COSM4930085	c.356A>G	p.Q119R	Substitution - Missense	Liver
COSM2874965	c.277C>T	p.P93S	Substitution - Missense	Large_intestine
COSM3901370	c.1486G>A	p.V496M	Substitution - Missense	Stomach
COSM1101449	c.1311C>T	p.R437R	Substitution - coding silent	Endometrium
COSM4805713	c.1318C>A	p.R440R	Substitution - coding silent	Liver
COSM1205872	c.1151A>G	p.Q384R	Substitution - Missense	Large_intestine
COSM239758	c.1674_1676delAGA	p.E561delE	Deletion - In frame	Prostate
COSM403014	c.1358G>A	p.G453E	Substitution - Missense	Lung
COSM3650731	c.614C>T	p.S205F	Substitution - Missense	Skin
COSM454818	c.626A>G	p.N209S	Substitution - Missense	Breast
COSM25395	c.336A>G	p.T112T	Substitution - coding silent	Upper_aerodigestive_tract
COSM750786	c.865G>C	p.D289H	Substitution - Missense	Lung
COSM43007	c.1082G>T	p.R361L	Substitution - Missense	Central_nervous_system
COSM4953991	c.1371T>A	p.G457G	Substitution - coding silent	Liver
COSM4901060	c.121G>A	p.E41K	Substitution - Missense	Skin
COSM116298	c.314C>G	p.T105S	Substitution - Missense	Ovary
COSM1101446	c.1703C>T	p.A568V	Substitution - Missense	Endometrium
COSM5929043	c.640-1G>A	p.?	Unknown	Skin
COSM2874955	c.448G>T	p.G150C	Substitution - Missense	Large_intestine
COSM1700240	c.1408G>A	p.E470K	Substitution - Missense	Skin
COSM5011919	c.911G>A	p.R304H	Substitution - Missense	Kidney
COSM2874978	c.26C>T	p.P9L	Substitution - Missense	Skin
COSM3716082	c.948C>T	p.P316P	Substitution - coding silent	Stomach
COSM145384	c.356A>T	p.Q119L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5721211	c.1678G>A	p.E560K	Substitution - Missense	Skin
COSM4529933	c.1654G>A	p.V552I	Substitution - Missense	Skin
COSM3901388	c.495C>T	p.S165S	Substitution - coding silent	Stomach
COSM3901390	c.214A>G	p.S72G	Substitution - Missense	Stomach
COSM1101452	c.1033G>A	p.A345T	Substitution - Missense	Endometrium
COSM1700243	c.1095G>A	p.M365I	Substitution - Missense	Skin
COSM4513950	c.956C>T	p.S319F	Substitution - Missense	Skin
COSM5697318	c.46A>G	p.S16G	Substitution - Missense	Soft_tissue
COSM230154	c.580G>A	p.G194R	Substitution - Missense	Skin
COSM4491592	c.382C>T	p.P128S	Substitution - Missense	Skin
COSM1179698	c.1107G>T	p.L369F	Substitution - Missense	Prostate
COSM4480936	c.246C>T	p.F82F	Substitution - coding silent	Skin
COSM5923464	c.478C>G	p.Q160E	Substitution - Missense	Skin
COSM5590841	c.1722C>T	p.I574I	Substitution - coding silent	Skin
COSM1700240	c.1408G>A	p.E470K	Substitution - Missense	Skin
COSM4878803	c.678C>T	p.Y226Y	Substitution - coding silent	Prostate
COSM364789	c.851C>A	p.S284*	Substitution - Nonsense	Stomach
COSM4493256	c.411C>T	p.S137S	Substitution - coding silent	Skin
COSM5721211	c.1678G>A	p.E560K	Substitution - Missense	Skin
COSM1700240	c.1408G>A	p.E470K	Substitution - Missense	Skin
COSM1700245	c.319G>A	p.A107T	Substitution - Missense	Skin
COSM3925556	c.410C>T	p.S137F	Substitution - Missense	Skin
COSM1101453	c.1008C>T	p.F336F	Substitution - coding silent	Endometrium
COSM1101447	c.1603G>T	p.E535*	Substitution - Nonsense	Endometrium
COSM4397573	c.4G>A	p.E2K	Substitution - Missense	Skin
COSM3942743	c.203C>A	p.A68E	Substitution - Missense	Oesophagus
COSM1205875	c.1121T>G	p.L374*	Substitution - Nonsense	Large_intestine
COSM3716082	c.948C>T	p.P316P	Substitution - coding silent	Upper_aerodigestive_tract
COSM145384	c.356A>T	p.Q119L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1101457	c.574T>C	p.S192P	Substitution - Missense	Endometrium
COSM4979389	c.1281T>G	p.G427G	Substitution - coding silent	Oesophagus
COSM1755792	c.230G>A	p.R77Q	Substitution - Missense	Urinary_tract
COSM43006	c.1460C>T	p.S487L	Substitution - Missense	Central_nervous_system
COSM1251615	c.1542G>C	p.L514L	Substitution - coding silent	Oesophagus
COSM4682125	c.646C>G	p.P216A	Substitution - Missense	Large_intestine
COSM4961032	c.701C>T	p.P234L	Substitution - Missense	Liver
COSM5693083	c.522A>T	p.Q174H	Substitution - Missense	Soft_tissue
COSM5437014	c.1396C>A	p.Q466K	Substitution - Missense	Oesophagus
COSM5808782	c.940T>G	p.S314A	Substitution - Missense	Liver
COSM3650716	c.1300T>C	p.L434L	Substitution - coding silent	Skin
COSM1700241	c.1373C>T	p.P458L	Substitution - Missense	Skin
COSM1700241	c.1373C>T	p.P458L	Substitution - Missense	Skin
COSM77669	c.1290G>T	p.W430C	Substitution - Missense	Ovary
COSM3901394	c.17T>C	p.L6P	Substitution - Missense	Stomach
COSM5815360	c.279A>G	p.P93P	Substitution - coding silent	Liver
COSM1673965	c.981G>A	p.W327*	Substitution - Nonsense	Large_intestine
COSM1205876	c.505A>C	p.S169R	Substitution - Missense	Large_intestine
COSM4151852	c.1381A>C	p.R461R	Substitution - coding silent	Ovary
COSM5791109	c.272+6A>T	p.?	Unknown	Breast
COSM4953991	c.1371T>A	p.G457G	Substitution - coding silent	Liver
COSM145384	c.356A>T	p.Q119L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3650731	c.614C>T	p.S205F	Substitution - Missense	Skin
COSM5409838	c.952G>A	p.D318N	Substitution - Missense	Skin
COSM4397573	c.4G>A	p.E2K	Substitution - Missense	Skin
COSM1458105	c.936T>A	p.N312K	Substitution - Missense	Large_intestine
COSM3745658	c.1709C>T	p.P570L	Substitution - Missense	Liver
COSM4151858	c.807A>C	p.A269A	Substitution - coding silent	Ovary
COSM5455688	c.28C>T	p.H10Y	Substitution - Missense	Large_intestine
COSM5409832	c.1708C>T	p.P570S	Substitution - Missense	Skin
COSM4138731	c.992A>G	p.E331G	Substitution - Missense	Stomach
COSM4939943	c.632C>T	p.S211L	Substitution - Missense	Liver
COSM1101456	c.794T>C	p.I265T	Substitution - Missense	Endometrium
COSM3925547	c.775C>G	p.Q259E	Substitution - Missense	Skin
COSM5935400	c.856C>T	p.P286S	Substitution - Missense	Skin
COSM5439019	c.1051-8T>C	p.?	Unknown	Oesophagus
COSM3834991	c.450T>G	p.G150G	Substitution - coding silent	Breast
COSM212074	c.175G>A	p.G59R	Substitution - Missense	Breast
COSM122921	c.950C>A	p.P317Q	Substitution - Missense	Upper_aerodigestive_tract
COSM4458113	c.1071C>T	p.S357S	Substitution - coding silent	Skin
COSM3901372	c.1446C>T	p.A482A	Substitution - coding silent	Stomach
COSM4470814	c.1684C>A	p.Q562K	Substitution - Missense	Skin
COSM4495642	c.458C>G	p.S153*	Substitution - Nonsense	Skin
COSM3650720	c.946C>T	p.P316S	Substitution - Missense	Skin
COSM1314182	c.310C>T	p.Q104*	Substitution - Nonsense	Urinary_tract
COSM4843918	c.1308C>T	p.F436F	Substitution - coding silent	Cervix
COSM195682	c.743C>T	p.T248M	Substitution - Missense	Stomach
COSM3650709	c.1530G>A	p.A510A	Substitution - coding silent	Skin
COSM5063315	c.966+2T>C	p.?	Unknown	Stomach
COSM5912799	c.1406C>T	p.A469V	Substitution - Missense	Skin
COSM230154	c.580G>A	p.G194R	Substitution - Missense	Skin
COSM380215	c.204A>T	p.A68A	Substitution - coding silent	Lung
COSM1205873	c.247T>A	p.S83T	Substitution - Missense	Large_intestine
COSM2874917	c.886C>T	p.R296C	Substitution - Missense	Stomach
COSM2874953	c.492C>T	p.L164L	Substitution - coding silent	Skin
COSM1458104	c.1032C>T	p.Y344Y	Substitution - coding silent	Large_intestine
COSM3901384	c.568A>G	p.T190A	Substitution - Missense	Stomach
COSM4682119	c.1475G>A	p.R492Q	Substitution - Missense	Large_intestine
COSM5946930	c.285A>T	p.P95P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1635857	c.1388C>T	p.A463V	Substitution - Missense	Liver
COSM5919556	c.949C>T	p.P317S	Substitution - Missense	Skin
COSM1673965	c.981G>A	p.W327*	Substitution - Nonsense	Large_intestine
COSM3901380	c.784C>T	p.P262S	Substitution - Missense	Stomach
COSM3779337	c.781C>G	p.P261A	Substitution - Missense	Urinary_tract
COSM3699157	c.229C>T	p.R77*	Substitution - Nonsense	Large_intestine
COSM3716082	c.948C>T	p.P316P	Substitution - coding silent	Upper_aerodigestive_tract
COSM4428594	c.1323A>G	p.V441V	Substitution - coding silent	Oesophagus
COSM394579	c.987G>A	p.L329L	Substitution - coding silent	Lung
COSM3925554	c.413C>T	p.S138L	Substitution - Missense	Large_intestine
COSM4649240	c.1441C>T	p.L481L	Substitution - coding silent	Large_intestine
COSM4516255	c.1734_1735GG>AA	p.D579N	Substitution - Missense	Skin
COSM5619586	c.521A>G	p.Q174R	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4416277	c.782C>T	p.P261L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1101447	c.1603G>T	p.E535*	Substitution - Nonsense	Endometrium
COSM1553268	c.75C>T	p.L25L	Substitution - coding silent	Skin
COSM3650723	c.884T>G	p.L295W	Substitution - Missense	Skin
COSM3650739	c.402C>T	p.Y134Y	Substitution - coding silent	Skin
COSM4682123	c.837A>G	p.T279T	Substitution - coding silent	Large_intestine
COSM3432548	c.1445C>T	p.A482V	Substitution - Missense	Large_intestine
COSM244329	c.1702G>A	p.A568T	Substitution - Missense	Endometrium
COSM4829837	c.1185C>T	p.N395N	Substitution - coding silent	Cervix
COSM3745662	c.781C>A	p.P261T	Substitution - Missense	Liver
COSM1101451	c.1108G>T	p.A370S	Substitution - Missense	Endometrium
COSM3650727	c.753C>T	p.S251S	Substitution - coding silent	Skin
COSM3763394	c.1278C>T	p.G426G	Substitution - coding silent	Large_intestine
COSM3663866	c.1320G>A	p.R440R	Substitution - coding silent	Liver
COSM1205874	c.244T>G	p.F82V	Substitution - Missense	Large_intestine
COSM4436654	c.1716G>T	p.W572C	Substitution - Missense	Oesophagus
COSM4905424	c.1698G>A	p.K566K	Substitution - coding silent	Skin
COSM5721211	c.1678G>A	p.E560K	Substitution - Missense	Skin
COSM1700240	c.1408G>A	p.E470K	Substitution - Missense	Skin
COSM3663866	c.1320G>A	p.R440R	Substitution - coding silent	Liver
COSM5042428	c.197G>A	p.G66D	Substitution - Missense	Liver
COSM3901386	c.524C>A	p.P175H	Substitution - Missense	Stomach
COSM280909	c.1092A>G	p.E364E	Substitution - coding silent	Large_intestine
COSM2874834	c.1310G>A	p.R437H	Substitution - Missense	Large_intestine
COSM5409834	c.1293G>A	p.M431I	Substitution - Missense	Skin
COSM4855040	c.1021A>G	p.T341A	Substitution - Missense	Cervix
COSM5798484	c.1518C>A	p.I506I	Substitution - coding silent	Breast
COSM3650713	c.1375G>C	p.A459P	Substitution - Missense	Skin
COSM606187	c.901G>T	p.G301W	Substitution - Missense	Skin
COSM1700243	c.1095G>A	p.M365I	Substitution - Missense	Skin
COSM1553269	c.637C>T	p.Q213*	Substitution - Nonsense	Large_intestine
COSM3925552	c.673C>G	p.Q225E	Substitution - Missense	Skin
COSM3650709	c.1530G>A	p.A510A	Substitution - coding silent	Skin
COSM397899	c.1434G>T	p.W478C	Substitution - Missense	Lung
COSM4451101	c.1060A>C	p.T354P	Substitution - Missense	Skin
COSM1700242	c.1214G>A	p.G405E	Substitution - Missense	Skin
COSM5711005	c.1672G>A	p.V558I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM454819	c.624T>C	p.F208F	Substitution - coding silent	Breast
COSM3650733	c.581G>A	p.G194E	Substitution - Missense	Skin
COSM5013850	c.922C>T	p.R308*	Substitution - Nonsense	Kidney
COSM3650731	c.614C>T	p.S205F	Substitution - Missense	Skin
COSM3650729	c.646C>T	p.P216S	Substitution - Missense	Skin
COSM4895370	c.113A>G	p.N38S	Substitution - Missense	Skin
COSM606187	c.901G>T	p.G301W	Substitution - Missense	Skin
COSM226200	c.752C>T	p.S251F	Substitution - Missense	Skin
COSM5440984	c.1675G>C	p.E559Q	Substitution - Missense	Oesophagus
COSM5976917	c.340T>C	p.F114L	Substitution - Missense	Upper_aerodigestive_tract
COSM5929041	c.640G>A	p.D214N	Substitution - Missense	Skin
COSM4682127	c.431C>T	p.A144V	Substitution - Missense	Large_intestine
COSM234232	c.264C>A	p.Y88*	Substitution - Nonsense	Skin
COSM5624035	c.1449G>A	p.L483L	Substitution - coding silent	Oesophagus
COSM5984832	c.1051G>A	p.D351N	Substitution - Missense	Upper_aerodigestive_tract
COSM5439017	c.1096A>C	p.I366L	Substitution - Missense	Oesophagus
COSM5573305	c.1475+1G>A	p.?	Unknown	Prostate
COSM234232	c.264C>A	p.Y88*	Substitution - Nonsense	Stomach
COSM3901374	c.1395G>T	p.L465L	Substitution - coding silent	Stomach
COSM4405250	c.1307T>C	p.F436S	Substitution - Missense	Skin
COSM5563126	c.27G>A	p.P9P	Substitution - coding silent	Prostate
COSM226200	c.752C>T	p.S251F	Substitution - Missense	Skin
COSM43006	c.1460C>T	p.S487L	Substitution - Missense	Central_nervous_system
COSM5459709	c.172G>A	p.D58N	Substitution - Missense	Large_intestine
COSM3901365	c.1641A>G	p.R547R	Substitution - coding silent	Stomach
COSM3996118	c.1275G>C	p.R425R	Substitution - coding silent	Kidney
COSM1101450	c.1217C>T	p.T406I	Substitution - Missense	Endometrium
COSM4940319	c.405C>A	p.G135G	Substitution - coding silent	Liver
COSM119900	c.1009C>T	p.H337Y	Substitution - Missense	Ovary
COSM3650731	c.614C>T	p.S205F	Substitution - Missense	Skin
COSM5345628	c.556+6T>C	p.?	Unknown	Large_intestine
COSM3669920	c.78T>C	p.G26G	Substitution - coding silent	Liver
COSM1458104	c.1032C>T	p.Y344Y	Substitution - coding silent	Prostate
COSM3925543	c.1199+2T>A	p.?	Unknown	Skin
COSM1755792	c.230G>A	p.R77Q	Substitution - Missense	Urinary_tract
COSM134251	c.1382G>A	p.R461K	Substitution - Missense	Skin
COSM3650718	c.1228C>T	p.P410S	Substitution - Missense	Skin
COSM3650725	c.863A>G	p.K288R	Substitution - Missense	Skin
COSM43007	c.1082G>T	p.R361L	Substitution - Missense	Central_nervous_system
COSM244329	c.1702G>A	p.A568T	Substitution - Missense	Prostate
COSM1700240	c.1408G>A	p.E470K	Substitution - Missense	Skin
COSM4944996	c.884T>C	p.L295S	Substitution - Missense	Liver
COSM1101448	c.1594A>C	p.I532L	Substitution - Missense	Endometrium
COSM2874819	c.1746C>T	p.A582A	Substitution - coding silent	Skin
COSM3650711	c.1426G>A	p.D476N	Substitution - Missense	Skin
COSM3650737	c.477A>T	p.G159G	Substitution - coding silent	Skin
COSM4682121	c.1389C>T	p.A463A	Substitution - coding silent	Large_intestine
COSM3901382	c.783G>A	p.P261P	Substitution - coding silent	Stomach
COSM1101454	c.994A>G	p.T332A	Substitution - Missense	Endometrium
COSM1673965	c.981G>A	p.W327*	Substitution - Nonsense	Large_intestine
COSM160860	c.746C>A	p.T249K	Substitution - Missense	Breast
COSM3650741	c.295C>T	p.P99S	Substitution - Missense	Skin
COSM4961032	c.701C>T	p.P234L	Substitution - Missense	Liver
COSM4985350	c.58C>G	p.P20A	Substitution - Missense	Soft_tissue
COSM4503744	c.647C>T	p.P216L	Substitution - Missense	Skin
COSM3779339	c.573A>T	p.T191T	Substitution - coding silent	Urinary_tract
COSM4138733	c.194C>A	p.S65*	Substitution - Nonsense	Kidney
COSM1101455	c.892G>T	p.G298C	Substitution - Missense	Endometrium
COSM4458113	c.1071C>T	p.S357S	Substitution - coding silent	Skin
COSM3650733	c.581G>A	p.G194E	Substitution - Missense	Skin
COSM5998131	c.1051-10C>A	p.?	Unknown	Prostate
COSM5941294	c.1384G>A	p.E462K	Substitution - Missense	Skin
COSM3650703	c.1729C>T	p.H577Y	Substitution - Missense	Skin
COSM5580984	c.1274G>A	p.R425Q	Substitution - Missense	Skin

> Text Mining based Variations [ TOP ]
There is no record for EYA1.

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	1.758	-1.678	-3.541	2.26e-09	Under
BRCA	Breast invasive carcinoma	112	1100	-0.115	-1.879	-1.617	4.02e-11	Under
CESC	Cervical and endocervical cancers	3	306	-5.262	-3.038	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	-2.276	-1.805	0.765	0.0875	NS
ESCA	Esophageal carcinoma	11	185	-0.696	-1.784	-1.387	0.14	NS
GBM	Glioblastoma multiforme	5	166	1.888	2.47	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	0.81	-1.576	-2.54	2.47e-11	Under
KIRC	Kidney renal clear cell carcinoma	72	534	-1.32	-2.642	-0.73	0.0406	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	-1.665	-2.01	-0.563	0.263	NS
LAML	Acute Myeloid Leukemia	0	173	NA	-2.362	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.599	NA	NA	NA
LUAD	Lung adenocarcinoma	59	517	0.122	-0.34	-0.397	0.274	NS
LUSC	Lung squamous cell carcinoma	51	501	-0.175	0.926	0.574	0.163	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	-2.456	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	-3.387	-2.415	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-3.887	-0.164	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.699	2.742	-1.092	1.38e-06	Under
READ	Rectum adenocarcinoma	10	167	-1.54	-1.238	0.458	0.662	NS
SARC	Sarcoma	2	263	0.999	1.413	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.601	1.202	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	-1.738	-2.294	-0.307	0.458	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	1.519	NA	NA	NA
THCA	Thyroid carcinoma	59	509	-0.017	-3.434	-3.518	4.85e-35	Under
THYM	Thymoma	2	120	4.701	5.188	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	-1.755	0.293	1.344	0.00867	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.9
Autonomic ganglia	CHP212	5.5
Autonomic ganglia	IMR32	9.8
Autonomic ganglia	KELLY	9
Autonomic ganglia	KPNRTBM1	4.7
Autonomic ganglia	KPNSI9S	7.5
Autonomic ganglia	KPNYN	9.1
Autonomic ganglia	MHHNB11	9.8
Autonomic ganglia	NB1	6.6
Autonomic ganglia	NH6	7.8
Autonomic ganglia	SHSY5Y	7.4
Autonomic ganglia	SIMA	8.5
Autonomic ganglia	SKNAS	8.6
Autonomic ganglia	SKNBE2	8.2
Autonomic ganglia	SKNDZ	6.9
Autonomic ganglia	SKNFI	9.7
Autonomic ganglia	SKNSH	5.9
Biliary tract	HUCCT1	3.8
Biliary tract	HUH28	4.1
Biliary tract	SNU1079	4.1
Biliary tract	SNU1196	3.9
Biliary tract	SNU245	3.9
Biliary tract	SNU308	4
Biliary tract	SNU478	4.2
Bone	143B	3.7
Bone	A673	5.2
Bone	CADOES1	4.1
Bone	CAL78	6.3
Bone	G292CLONEA141B1	5.9
Bone	HOS	4
Bone	HS706T	6.8
Bone	HS737T	4.4
Bone	HS819T	4.3
Bone	HS821T	6.3
Bone	HS822T	4
Bone	HS863T	4
Bone	HS870T	4.6
Bone	HS888T	4.2
Bone	MG63	4.9
Bone	MHHES1	7.8
Bone	OUMS27	3.9
Bone	RDES	5.5
Bone	SJSA1	4.3
Bone	SKES1	6.5
Bone	SKNMC	5.9
Bone	SW1353	4.6
Bone	T173	4.8
Bone	TC71	5.2
Bone	U2OS	4.4
Breast	AU565	3.7
Breast	BT20	3.8
Breast	BT474	3.7
Breast	BT483	4.2
Breast	BT549	5.3
Breast	CAL120	3.9
Breast	CAL148	3.9
Breast	CAL51	4.1
Breast	CAL851	3.9
Breast	CAMA1	3.9
Breast	DU4475	4.6
Breast	EFM192A	3.7
Breast	EFM19	4.1
Breast	EVSAT	3.9
Breast	HCC1143	4.3
Breast	HCC1187	3.8
Breast	HCC1395	8.2
Breast	HCC1419	4.2
Breast	HCC1428	4.2
Breast	HCC1500	8.5
Breast	HCC1569	4.2
Breast	HCC1599	4.1
Breast	HCC1806	4.1
Breast	HCC1937	4
Breast	HCC1954	4
Breast	HCC202	3.9
Breast	HCC2157	4.2
Breast	HCC2218	4.5
Breast	HCC38	3.9
Breast	HCC70	3.7
Breast	HDQP1	3.9
Breast	HMC18	4.1
Breast	HS274T	4.2
Breast	HS281T	4.4
Breast	HS343T	4.7
Breast	HS578T	4
Breast	HS606T	4.3
Breast	HS739T	4.2
Breast	HS742T	4
Breast	JIMT1	4
Breast	KPL1	3.9
Breast	MCF7	4
Breast	MDAMB134VI	4
Breast	MDAMB157	7.1
Breast	MDAMB175VII	3.9
Breast	MDAMB231	4
Breast	MDAMB361	4
Breast	MDAMB415	3.9
Breast	MDAMB436	5.5
Breast	MDAMB453	4.1
Breast	MDAMB468	4
Breast	SKBR3	3.7
Breast	T47D	4.2
Breast	UACC812	4
Breast	UACC893	3.9
Breast	YMB1	4.1
Breast	ZR751	4
Breast	ZR7530	4
Central nervous system	1321N1	3.7
Central nervous system	42MGBA	6
Central nervous system	8MGBA	8.9
Central nervous system	A172	4.1
Central nervous system	AM38	4.3
Central nervous system	BECKER	6
Central nervous system	CAS1	6
Central nervous system	CCFSTTG1	8.7
Central nervous system	D283MED	3.9
Central nervous system	D341MED	4.4
Central nervous system	DAOY	5.3
Central nervous system	DBTRG05MG	3.8
Central nervous system	DKMG	5.1
Central nervous system	GAMG	4
Central nervous system	GB1	3.7
Central nervous system	GI1	6.5
Central nervous system	GMS10	6.2
Central nervous system	GOS3	6.5
Central nervous system	H4	7
Central nervous system	HS683	7.3
Central nervous system	KALS1	3.7
Central nervous system	KG1C	4
Central nervous system	KNS42	4
Central nervous system	KNS60	6.1
Central nervous system	KNS81	3.7
Central nervous system	KS1	5.4
Central nervous system	LN18	3.9
Central nervous system	LN229	4.1
Central nervous system	M059K	4.2
Central nervous system	MOGGCCM	4.5
Central nervous system	MOGGUVW	7.5
Central nervous system	NMCG1	3.9
Central nervous system	ONS76	4.2
Central nervous system	SF126	6.4
Central nervous system	SF295	7.5
Central nervous system	SNB19	5.1
Central nervous system	SNU1105	6.3
Central nervous system	SNU201	7.4
Central nervous system	SNU466	4.4
Central nervous system	SNU489	4.5
Central nervous system	SNU626	5.1
Central nervous system	SNU738	4.5
Central nervous system	SW1088	4.9
Central nervous system	SW1783	3.5
Central nervous system	T98G	8.2
Central nervous system	TM31	3.7
Central nervous system	U118MG	7
Central nervous system	U138MG	6
Central nervous system	U251MG	4.2
Central nervous system	U87MG	6.4
Central nervous system	YH13	3.8
Central nervous system	YKG1	3.9
Endometrium	AN3CA	8.3
Endometrium	COLO684	4.3
Endometrium	EFE184	4.1
Endometrium	EN	3.9
Endometrium	ESS1	3.9
Endometrium	HEC108	3.8
Endometrium	HEC151	3.9
Endometrium	HEC1A	3.8
Endometrium	HEC1B	3.8
Endometrium	HEC251	3.8
Endometrium	HEC265	4.2
Endometrium	HEC50B	3.8
Endometrium	HEC59	4.2
Endometrium	HEC6	4.3
Endometrium	ISHIKAWAHERAKLIO02ER	4.3
Endometrium	JHUEM1	3.9
Endometrium	JHUEM2	4
Endometrium	JHUEM3	4.8
Endometrium	KLE	3.9
Endometrium	MFE280	4.3
Endometrium	MFE296	4.2
Endometrium	MFE319	4.1
Endometrium	RL952	4.3
Endometrium	SNGM	3.8
Endometrium	SNU1077	3.9
Endometrium	SNU685	6.1
Endometrium	TEN	3.7
Haematopoietic and lymphoid	697	4.2
Haematopoietic and lymphoid	A3KAW	7.1
Haematopoietic and lymphoid	A4FUK	7.3
Haematopoietic and lymphoid	ALLSIL	4.2
Haematopoietic and lymphoid	AML193	4.2
Haematopoietic and lymphoid	AMO1	5
Haematopoietic and lymphoid	BCP1	8.5
Haematopoietic and lymphoid	BDCM	7.1
Haematopoietic and lymphoid	BL41	4.2
Haematopoietic and lymphoid	BL70	3.9
Haematopoietic and lymphoid	BV173	3.9
Haematopoietic and lymphoid	CA46	4.2
Haematopoietic and lymphoid	CI1	4.5
Haematopoietic and lymphoid	CMK115	4
Haematopoietic and lymphoid	CMK86	3.8
Haematopoietic and lymphoid	CMK	4.4
Haematopoietic and lymphoid	CMLT1	4
Haematopoietic and lymphoid	COLO775	7.8
Haematopoietic and lymphoid	DAUDI	4.2
Haematopoietic and lymphoid	DB	3.7
Haematopoietic and lymphoid	DEL	4.4
Haematopoietic and lymphoid	DND41	4
Haematopoietic and lymphoid	DOHH2	4.1
Haematopoietic and lymphoid	EB1	4.1
Haematopoietic and lymphoid	EB2	4
Haematopoietic and lymphoid	EHEB	3.9
Haematopoietic and lymphoid	EJM	4
Haematopoietic and lymphoid	EM2	4
Haematopoietic and lymphoid	EOL1	4.2
Haematopoietic and lymphoid	F36P	3.9
Haematopoietic and lymphoid	GA10	3.8
Haematopoietic and lymphoid	GDM1	4.3
Haematopoietic and lymphoid	GRANTA519	5.1
Haematopoietic and lymphoid	HDLM2	4.1
Haematopoietic and lymphoid	HDMYZ	4
Haematopoietic and lymphoid	HEL9217	4.2
Haematopoietic and lymphoid	HEL	3.9
Haematopoietic and lymphoid	HH	3.9
Haematopoietic and lymphoid	HL60	4.5
Haematopoietic and lymphoid	HPBALL	3.9
Haematopoietic and lymphoid	HS604T	4.3
Haematopoietic and lymphoid	HS611T	4
Haematopoietic and lymphoid	HS616T	3.7
Haematopoietic and lymphoid	HS751T	3.9
Haematopoietic and lymphoid	HT	4.1
Haematopoietic and lymphoid	HTK	4.1
Haematopoietic and lymphoid	HUNS1	4.2
Haematopoietic and lymphoid	HUT102	4.1
Haematopoietic and lymphoid	HUT78	4.3
Haematopoietic and lymphoid	JEKO1	4.2
Haematopoietic and lymphoid	JK1	4.1
Haematopoietic and lymphoid	JM1	4.1
Haematopoietic and lymphoid	JURKAT	4.1
Haematopoietic and lymphoid	JURLMK1	3.9
Haematopoietic and lymphoid	JVM2	3.8
Haematopoietic and lymphoid	JVM3	7.6
Haematopoietic and lymphoid	K562	4.2
Haematopoietic and lymphoid	KARPAS299	4
Haematopoietic and lymphoid	KARPAS422	4.3
Haematopoietic and lymphoid	KARPAS620	8
Haematopoietic and lymphoid	KASUMI1	4.1
Haematopoietic and lymphoid	KASUMI2	4
Haematopoietic and lymphoid	KASUMI6	4
Haematopoietic and lymphoid	KCL22	3.8
Haematopoietic and lymphoid	KE37	4.1
Haematopoietic and lymphoid	KE97	4.3
Haematopoietic and lymphoid	KG1	3.9
Haematopoietic and lymphoid	KHM1B	6
Haematopoietic and lymphoid	KIJK	4
Haematopoietic and lymphoid	KMH2	6.2
Haematopoietic and lymphoid	KMM1	3.9
Haematopoietic and lymphoid	KMS11	9.1
Haematopoietic and lymphoid	KMS12BM	5.6
Haematopoietic and lymphoid	KMS18	4
Haematopoietic and lymphoid	KMS20	4.3
Haematopoietic and lymphoid	KMS21BM	7.5
Haematopoietic and lymphoid	KMS26	8
Haematopoietic and lymphoid	KMS27	6.3
Haematopoietic and lymphoid	KMS28BM	4.3
Haematopoietic and lymphoid	KMS34	6.9
Haematopoietic and lymphoid	KO52	5.7
Haematopoietic and lymphoid	KOPN8	4
Haematopoietic and lymphoid	KU812	4.2
Haematopoietic and lymphoid	KYO1	6.2
Haematopoietic and lymphoid	L1236	3.9
Haematopoietic and lymphoid	L363	4.2
Haematopoietic and lymphoid	L428	6.5
Haematopoietic and lymphoid	L540	4.3
Haematopoietic and lymphoid	LAMA84	4.2
Haematopoietic and lymphoid	LOUCY	4.2
Haematopoietic and lymphoid	LP1	8.6
Haematopoietic and lymphoid	M07E	4
Haematopoietic and lymphoid	MC116	3.7
Haematopoietic and lymphoid	ME1	4
Haematopoietic and lymphoid	MEC1	6.4
Haematopoietic and lymphoid	MEC2	3.7
Haematopoietic and lymphoid	MEG01	4.1
Haematopoietic and lymphoid	MHHCALL2	3.8
Haematopoietic and lymphoid	MHHCALL3	4.1
Haematopoietic and lymphoid	MHHCALL4	4.2
Haematopoietic and lymphoid	MINO	4.1
Haematopoietic and lymphoid	MJ	4.2
Haematopoietic and lymphoid	MM1S	8.3
Haematopoietic and lymphoid	MOLM13	4.1
Haematopoietic and lymphoid	MOLM16	7.2
Haematopoietic and lymphoid	MOLM6	4.3
Haematopoietic and lymphoid	MOLP2	3.6
Haematopoietic and lymphoid	MOLP8	10.2
Haematopoietic and lymphoid	MOLT13	4.2
Haematopoietic and lymphoid	MOLT16	4.1
Haematopoietic and lymphoid	MOLT4	3.6
Haematopoietic and lymphoid	MONOMAC1	4.2
Haematopoietic and lymphoid	MONOMAC6	3.8
Haematopoietic and lymphoid	MOTN1	4.3
Haematopoietic and lymphoid	MUTZ5	3.6
Haematopoietic and lymphoid	MV411	3.8
Haematopoietic and lymphoid	NALM19	3.8
Haematopoietic and lymphoid	NALM1	3.8
Haematopoietic and lymphoid	NALM6	4.1
Haematopoietic and lymphoid	NAMALWA	3.6
Haematopoietic and lymphoid	NB4	3.9
Haematopoietic and lymphoid	NCIH929	4.7
Haematopoietic and lymphoid	NCO2	5
Haematopoietic and lymphoid	NOMO1	4.4
Haematopoietic and lymphoid	NUDHL1	3.9
Haematopoietic and lymphoid	NUDUL1	3.9
Haematopoietic and lymphoid	OCIAML2	3.9
Haematopoietic and lymphoid	OCIAML3	4.2
Haematopoietic and lymphoid	OCIAML5	4.6
Haematopoietic and lymphoid	OCILY10	3.9
Haematopoietic and lymphoid	OCILY19	3.9
Haematopoietic and lymphoid	OCILY3	4.4
Haematopoietic and lymphoid	OCIM1	8.7
Haematopoietic and lymphoid	OPM2	10.9
Haematopoietic and lymphoid	P12ICHIKAWA	4.1
Haematopoietic and lymphoid	P31FUJ	4
Haematopoietic and lymphoid	P3HR1	4.3
Haematopoietic and lymphoid	PCM6	4.3
Haematopoietic and lymphoid	PEER	4
Haematopoietic and lymphoid	PF382	4.1
Haematopoietic and lymphoid	PFEIFFER	4
Haematopoietic and lymphoid	PL21	4.3
Haematopoietic and lymphoid	RAJI	4.2
Haematopoietic and lymphoid	RCHACV	4.2
Haematopoietic and lymphoid	REC1	4.1
Haematopoietic and lymphoid	REH	3.8
Haematopoietic and lymphoid	RI1	4
Haematopoietic and lymphoid	RL	4
Haematopoietic and lymphoid	RPMI8226	7.3
Haematopoietic and lymphoid	RPMI8402	4.1
Haematopoietic and lymphoid	RS411	4.8
Haematopoietic and lymphoid	SEM	5.1
Haematopoietic and lymphoid	SET2	3.9
Haematopoietic and lymphoid	SIGM5	4
Haematopoietic and lymphoid	SKM1	3.9
Haematopoietic and lymphoid	SKMM2	7
Haematopoietic and lymphoid	SR786	4.3
Haematopoietic and lymphoid	ST486	4.3
Haematopoietic and lymphoid	SUDHL10	4.2
Haematopoietic and lymphoid	SUDHL1	4.3
Haematopoietic and lymphoid	SUDHL4	4.1
Haematopoietic and lymphoid	SUDHL5	4.2
Haematopoietic and lymphoid	SUDHL6	4
Haematopoietic and lymphoid	SUDHL8	4.3
Haematopoietic and lymphoid	SUPB15	3.7
Haematopoietic and lymphoid	SUPHD1	4.2
Haematopoietic and lymphoid	SUPM2	4.1
Haematopoietic and lymphoid	SUPT11	3.8
Haematopoietic and lymphoid	SUPT1	3.9
Haematopoietic and lymphoid	TALL1	3.9
Haematopoietic and lymphoid	TF1	4
Haematopoietic and lymphoid	THP1	4.2
Haematopoietic and lymphoid	TO175T	3.9
Haematopoietic and lymphoid	TOLEDO	4
Haematopoietic and lymphoid	U266B1	4
Haematopoietic and lymphoid	U937	4
Haematopoietic and lymphoid	UT7	3.9
Haematopoietic and lymphoid	WSUDLCL2	4.1
Kidney	769P	4.1
Kidney	786O	3.7
Kidney	A498	4
Kidney	A704	7.5
Kidney	ACHN	3.7
Kidney	BFTC909	4.6
Kidney	CAKI1	4.8
Kidney	CAKI2	3.9
Kidney	CAL54	3.9
Kidney	KMRC1	4.7
Kidney	KMRC20	3.8
Kidney	KMRC2	3.8
Kidney	KMRC3	4
Kidney	OSRC2	4.3
Kidney	RCC10RGB	4.2
Kidney	SNU1272	3.9
Kidney	SNU349	6.6
Kidney	TUHR10TKB	5.5
Kidney	TUHR14TKB	4
Kidney	TUHR4TKB	5.6
Kidney	VMRCRCW	4.2
Kidney	VMRCRCZ	3.7
Large intestine	C2BBE1	3.7
Large intestine	CCK81	3.9
Large intestine	CL11	3.7
Large intestine	CL14	4.1
Large intestine	CL34	3.7
Large intestine	CL40	3.7
Large intestine	COLO205	4.1
Large intestine	COLO320	4.6
Large intestine	COLO678	3.9
Large intestine	CW2	3.8
Large intestine	DLD1	4.2
Large intestine	GP2D	4.3
Large intestine	HCC56	3.8
Large intestine	HCT116	3.9
Large intestine	HCT15	4
Large intestine	HS675T	4
Large intestine	HS698T	3.8
Large intestine	HT115	3.8
Large intestine	HT29	3.5
Large intestine	HT55	3.9
Large intestine	KM12	4.2
Large intestine	LOVO	4.1
Large intestine	LS1034	4
Large intestine	LS123	4.5
Large intestine	LS180	3.9
Large intestine	LS411N	3.8
Large intestine	LS513	4.2
Large intestine	MDST8	4
Large intestine	NCIH508	3.8
Large intestine	NCIH716	4.1
Large intestine	NCIH747	4.1
Large intestine	OUMS23	3.8
Large intestine	RCM1	4
Large intestine	RKO	4
Large intestine	SKCO1	4.2
Large intestine	SNU1040	4.2
Large intestine	SNU1197	4.1
Large intestine	SNU175	4
Large intestine	SNU283	4.1
Large intestine	SNU407	5.2
Large intestine	SNU503	4.3
Large intestine	SNU61	4.1
Large intestine	SNU81	4.4
Large intestine	SNUC1	3.9
Large intestine	SNUC2A	3.9
Large intestine	SNUC4	3.7
Large intestine	SNUC5	3.8
Large intestine	SW1116	4.2
Large intestine	SW1417	3.8
Large intestine	SW1463	3.8
Large intestine	SW403	3.6
Large intestine	SW480	3.8
Large intestine	SW48	3.9
Large intestine	SW620	3.7
Large intestine	SW837	3.9
Large intestine	SW948	3.6
Large intestine	T84	3.8
Liver	ALEXANDERCELLS	4.2
Liver	C3A	3.6
Liver	HEP3B217	4.2
Liver	HEPG2	3.9
Liver	HLE	4.1
Liver	HLF	3.8
Liver	HUH1	3.7
Liver	HUH6	3.9
Liver	HUH7	3.8
Liver	JHH1	3.8
Liver	JHH2	3.8
Liver	JHH4	3.9
Liver	JHH5	4.2
Liver	JHH6	3.9
Liver	JHH7	4
Liver	LI7	3.5
Liver	PLCPRF5	3.9
Liver	SKHEP1	3.9
Liver	SNU182	4.3
Liver	SNU387	5
Liver	SNU398	3.9
Liver	SNU423	4.1
Liver	SNU449	4.1
Liver	SNU475	6.3
Liver	SNU761	4.8
Liver	SNU878	4.4
Liver	SNU886	5
Lung	A549	4.1
Lung	ABC1	4.7
Lung	BEN	6
Lung	CAL12T	4.4
Lung	CALU1	6.2
Lung	CALU3	4.5
Lung	CALU6	4.4
Lung	CHAGOK1	4.1
Lung	COLO668	7.8
Lung	COLO699	6.4
Lung	CORL105	3.9
Lung	CORL23	5.1
Lung	CORL24	10.6
Lung	CORL279	4.1
Lung	CORL311	5.9
Lung	CORL47	10
Lung	CORL51	4.8
Lung	CORL88	7.9
Lung	CORL95	3.8
Lung	CPCN	12.9
Lung	DMS114	10.4
Lung	DMS153	4.1
Lung	DMS273	5.7
Lung	DMS454	6.1
Lung	DMS53	6.4
Lung	DMS79	4.2
Lung	DV90	3.9
Lung	EBC1	5.8
Lung	EPLC272H	4.6
Lung	HARA	4.1
Lung	HCC1171	4.5
Lung	HCC1195	3.9
Lung	HCC15	4
Lung	HCC2279	5.9
Lung	HCC2935	3.7
Lung	HCC33	8.8
Lung	HCC366	3.9
Lung	HCC4006	4.2
Lung	HCC44	4
Lung	HCC78	6
Lung	HCC827	5
Lung	HCC95	4.5
Lung	HLC1	8
Lung	HLFA	4.2
Lung	HS229T	3.9
Lung	HS618T	4.6
Lung	IALM	5.8
Lung	KNS62	4.4
Lung	LC1F	4.1
Lung	LC1SQSF	6.4
Lung	LCLC103H	4.4
Lung	LCLC97TM1	7.7
Lung	LK2	4.4
Lung	LOUNH91	4
Lung	LU65	3.7
Lung	LU99	4.5
Lung	LUDLU1	4.4
Lung	LXF289	4
Lung	MORCPR	4.1
Lung	NCIH1048	3.9
Lung	NCIH1092	6.8
Lung	NCIH1105	4.5
Lung	NCIH1155	3.8
Lung	NCIH1184	6.3
Lung	NCIH1299	5
Lung	NCIH1339	5
Lung	NCIH1341	10.1
Lung	NCIH1355	3.9
Lung	NCIH1373	4.4
Lung	NCIH1385	4.2
Lung	NCIH1395	4.4
Lung	NCIH1435	3.8
Lung	NCIH1436	4.6
Lung	NCIH1437	3.6
Lung	NCIH146	9
Lung	NCIH1563	4
Lung	NCIH1568	3.9
Lung	NCIH1573	3.8
Lung	NCIH1581	5.7
Lung	NCIH1618	5.5
Lung	NCIH1623	4
Lung	NCIH1648	4.1
Lung	NCIH1650	3.7
Lung	NCIH1651	4.8
Lung	NCIH1666	3.6
Lung	NCIH1693	4
Lung	NCIH1694	4.5
Lung	NCIH1703	3.8
Lung	NCIH1734	4.3
Lung	NCIH1755	3.5
Lung	NCIH1781	5
Lung	NCIH1792	4.1
Lung	NCIH1793	3.9
Lung	NCIH1836	9.4
Lung	NCIH1838	6.9
Lung	NCIH1869	5.4
Lung	NCIH1876	8.1
Lung	NCIH1915	6.2
Lung	NCIH1930	4.6
Lung	NCIH1944	4.2
Lung	NCIH1963	9.7
Lung	NCIH196	7.8
Lung	NCIH1975	3.9
Lung	NCIH2009	4.6
Lung	NCIH2023	3.7
Lung	NCIH2029	6.5
Lung	NCIH2030	4.2
Lung	NCIH2066	3.8
Lung	NCIH2081	5.3
Lung	NCIH2085	4.3
Lung	NCIH2087	7.9
Lung	NCIH209	4.6
Lung	NCIH2106	8.8
Lung	NCIH2110	4
Lung	NCIH211	9.3
Lung	NCIH2122	4.4
Lung	NCIH2126	4
Lung	NCIH2141	5
Lung	NCIH2170	4
Lung	NCIH2171	8.4
Lung	NCIH2172	4.5
Lung	NCIH2196	3.9
Lung	NCIH2227	3.9
Lung	NCIH2228	4.3
Lung	NCIH226	3.9
Lung	NCIH2286	3.9
Lung	NCIH2291	4.3
Lung	NCIH2342	3.9
Lung	NCIH2347	4.6
Lung	NCIH23	4.1
Lung	NCIH2405	3.9
Lung	NCIH2444	5.8
Lung	NCIH292	3.7
Lung	NCIH322	4.2
Lung	NCIH3255	5.2
Lung	NCIH358	6.8
Lung	NCIH441	4.4
Lung	NCIH446	8.9
Lung	NCIH460	3.5
Lung	NCIH510	4.1
Lung	NCIH520	4.1
Lung	NCIH522	3.9
Lung	NCIH524	7.6
Lung	NCIH526	4.4
Lung	NCIH596	3.7
Lung	NCIH647	6.5
Lung	NCIH650	4.5
Lung	NCIH661	4
Lung	NCIH69	9.2
Lung	NCIH727	4
Lung	NCIH810	4.3
Lung	NCIH82	10.4
Lung	NCIH838	3.7
Lung	NCIH841	3.9
Lung	NCIH854	4.2
Lung	NCIH889	6.7
Lung	PC14	5
Lung	RERFLCAD1	4.9
Lung	RERFLCAD2	4.8
Lung	RERFLCAI	4.1
Lung	RERFLCKJ	3.9
Lung	RERFLCMS	3.7
Lung	RERFLCSQ1	3.9
Lung	SBC5	4
Lung	SCLC21H	5.9
Lung	SHP77	4.3
Lung	SKLU1	6.9
Lung	SKMES1	4.3
Lung	SQ1	5.5
Lung	SW1271	3.8
Lung	SW1573	3.9
Lung	SW900	6
Lung	VMRCLCD	4.7
Lung	VMRCLCP	6.4
Oesophagus	COLO680N	3.8
Oesophagus	ECGI10	3.7
Oesophagus	KYSE140	3.9
Oesophagus	KYSE150	4.5
Oesophagus	KYSE180	3.9
Oesophagus	KYSE270	4.5
Oesophagus	KYSE30	6.2
Oesophagus	KYSE410	6.2
Oesophagus	KYSE450	4.4
Oesophagus	KYSE510	4
Oesophagus	KYSE520	4.4
Oesophagus	KYSE70	4.3
Oesophagus	OE19	4.2
Oesophagus	OE33	4
Oesophagus	TE10	5.2
Oesophagus	TE11	4.6
Oesophagus	TE14	4.5
Oesophagus	TE15	5.1
Oesophagus	TE1	4.2
Oesophagus	TE4	5.8
Oesophagus	TE5	4.2
Oesophagus	TE6	4.9
Oesophagus	TE8	3.9
Oesophagus	TE9	4.8
Oesophagus	TT	4
Ovary	59M	4.1
Ovary	A2780	3.9
Ovary	CAOV3	4.6
Ovary	CAOV4	4.2
Ovary	COLO704	4.6
Ovary	COV318	3.7
Ovary	COV362	6.3
Ovary	COV434	4.2
Ovary	COV504	4.6
Ovary	COV644	4.4
Ovary	EFO21	3.8
Ovary	EFO27	3.9
Ovary	ES2	4.2
Ovary	FUOV1	4
Ovary	HEYA8	4.1
Ovary	HS571T	3.9
Ovary	IGROV1	4.1
Ovary	JHOC5	4.2
Ovary	JHOM1	5.4
Ovary	JHOM2B	3.8
Ovary	JHOS2	4.3
Ovary	JHOS4	3.9
Ovary	KURAMOCHI	5.1
Ovary	MCAS	4.1
Ovary	NIHOVCAR3	4.2
Ovary	OAW28	4.6
Ovary	OAW42	4
Ovary	OC314	3.7
Ovary	OC316	4.1
Ovary	ONCODG1	4.1
Ovary	OV56	4.3
Ovary	OV7	4
Ovary	OV90	3.9
Ovary	OVCAR4	3.9
Ovary	OVCAR8	4.4
Ovary	OVISE	3.5
Ovary	OVK18	3.9
Ovary	OVKATE	3.8
Ovary	OVMANA	3.9
Ovary	OVSAHO	4.1
Ovary	OVTOKO	3.8
Ovary	RMGI	3.7
Ovary	RMUGS	4.2
Ovary	SKOV3	3.8
Ovary	SNU119	3.9
Ovary	SNU840	4.2
Ovary	SNU8	4.3
Ovary	TOV112D	4
Ovary	TOV21G	3.7
Ovary	TYKNU	4.1
Pancreas	ASPC1	4
Pancreas	BXPC3	5.2
Pancreas	CAPAN1	5.6
Pancreas	CAPAN2	3.9
Pancreas	CFPAC1	4.4
Pancreas	DANG	4.4
Pancreas	HPAC	5
Pancreas	HPAFII	3.9
Pancreas	HS766T	3.9
Pancreas	HUPT3	4.5
Pancreas	HUPT4	6.9
Pancreas	KCIMOH1	5.4
Pancreas	KLM1	6.1
Pancreas	KP2	4.4
Pancreas	KP3	6.4
Pancreas	KP4	4.1
Pancreas	L33	4.7
Pancreas	MIAPACA2	3.8
Pancreas	PANC0203	4.3
Pancreas	PANC0213	3.9
Pancreas	PANC0327	6.2
Pancreas	PANC0403	4.2
Pancreas	PANC0504	4.4
Pancreas	PANC0813	4.2
Pancreas	PANC1005	3.9
Pancreas	PANC1	4.9
Pancreas	PATU8902	4.4
Pancreas	PATU8988S	4.2
Pancreas	PATU8988T	4.2
Pancreas	PK1	4.6
Pancreas	PK45H	5.3
Pancreas	PK59	3.8
Pancreas	PL45	4.2
Pancreas	PSN1	3.8
Pancreas	QGP1	4
Pancreas	SNU213	4.5
Pancreas	SNU324	5.3
Pancreas	SNU410	4.2
Pancreas	SU8686	5.4
Pancreas	SUIT2	4.1
Pancreas	SW1990	4
Pancreas	T3M4	4.6
Pancreas	TCCPAN2	4.2
Pancreas	YAPC	4.8
Pleura	ACCMESO1	4.2
Pleura	DM3	4
Pleura	ISTMES1	4
Pleura	ISTMES2	3.8
Pleura	JL1	4
Pleura	MPP89	3.9
Pleura	MSTO211H	3.9
Pleura	NCIH2052	3.8
Pleura	NCIH2452	3.7
Pleura	NCIH28	4.1
Prostate	22RV1	3.6
Prostate	DU145	4
Prostate	LNCAPCLONEFGC	3.9
Prostate	MDAPCA2B	3.7
Prostate	NCIH660	9.3
Prostate	PC3	4
Prostate	VCAP	4.8
Salivary gland	A253	3.9
Salivary gland	YD15	4
Skin	A101D	6.8
Skin	A2058	10
Skin	A375	8.5
Skin	C32	8.8
Skin	CHL1	4.1
Skin	CJM	3.8
Skin	COLO679	7.2
Skin	COLO741	5.4
Skin	COLO783	4
Skin	COLO792	5.2
Skin	COLO800	7.2
Skin	COLO818	6.4
Skin	COLO829	8.7
Skin	COLO849	7.4
Skin	G361	4.8
Skin	GRM	3.7
Skin	HMCB	4
Skin	HS294T	5.1
Skin	HS600T	3.7
Skin	HS688AT	4
Skin	HS695T	4.1
Skin	HS839T	4.2
Skin	HS852T	7.2
Skin	HS895T	4
Skin	HS934T	4.1
Skin	HS936T	4.7
Skin	HS939T	5.9
Skin	HS940T	4.4
Skin	HS944T	6.4
Skin	HT144	5
Skin	IGR1	7.9
Skin	IGR37	5.8
Skin	IGR39	4.3
Skin	IPC298	6.6
Skin	K029AX	7.4
Skin	LOXIMVI	4.7
Skin	MALME3M	4.5
Skin	MDAMB435S	4.7
Skin	MELHO	6.5
Skin	MELJUSO	4.7
Skin	MEWO	4.3
Skin	RPMI7951	6.9
Skin	RVH421	8.3
Skin	SH4	8.2
Skin	SKMEL1	4.6
Skin	SKMEL24	7.1
Skin	SKMEL28	6.7
Skin	SKMEL2	7.8
Skin	SKMEL30	5.2
Skin	SKMEL31	6.3
Skin	SKMEL3	4.1
Skin	SKMEL5	5.4
Skin	UACC257	7.3
Skin	UACC62	6.6
Skin	WM115	4.9
Skin	WM1799	9.1
Skin	WM2664	7.7
Skin	WM793	7.3
Skin	WM88	6.6
Skin	WM983B	7.6
Small intestine	HUTU80	4.2
Soft tissue	A204	3.9
Soft tissue	G401	3.7
Soft tissue	G402	4
Soft tissue	GCT	5.1
Soft tissue	HS729	4.1
Soft tissue	HT1080	4.6
Soft tissue	KYM1	4.3
Soft tissue	MESSA	3.8
Soft tissue	RD	6.8
Soft tissue	RH30	7.5
Soft tissue	RH41	9.2
Soft tissue	RKN	3.9
Soft tissue	S117	4.6
Soft tissue	SJRH30	8.1
Soft tissue	SKLMS1	5.4
Soft tissue	SKUT1	4.2
Soft tissue	TE125T	4.4
Soft tissue	TE159T	4.4
Soft tissue	TE441T	4.1
Soft tissue	TE617T	3.9
Stomach	2313287	4
Stomach	AGS	4.1
Stomach	AZ521	4
Stomach	ECC10	4
Stomach	ECC12	3.8
Stomach	FU97	3.9
Stomach	GCIY	3.9
Stomach	GSS	4
Stomach	GSU	3.8
Stomach	HGC27	7.6
Stomach	HS746T	6.6
Stomach	HUG1N	3.9
Stomach	IM95	3.9
Stomach	KATOIII	3.9
Stomach	KE39	4
Stomach	LMSU	5.5
Stomach	MKN1	4
Stomach	MKN45	4
Stomach	MKN74	3.9
Stomach	MKN7	4.2
Stomach	NCCSTCK140	3.9
Stomach	NCIN87	5.9
Stomach	NUGC2	3.7
Stomach	NUGC3	4.3
Stomach	NUGC4	3.6
Stomach	OCUM1	4.1
Stomach	RERFGC1B	4
Stomach	SH10TC	3.8
Stomach	SNU16	3.6
Stomach	SNU1	3.8
Stomach	SNU216	6.9
Stomach	SNU520	4
Stomach	SNU5	3.9
Stomach	SNU601	3.8
Stomach	SNU620	3.8
Stomach	SNU668	3.8
Stomach	SNU719	3.5
Stomach	TGBC11TKB	3.9
Thyroid	8305C	6.4
Thyroid	8505C	4.3
Thyroid	BCPAP	4
Thyroid	BHT101	6.8
Thyroid	CAL62	4.4
Thyroid	CGTHW1	4.3
Thyroid	FTC133	3.8
Thyroid	FTC238	6.5
Thyroid	ML1	6.4
Thyroid	SW579	5.2
Thyroid	TT2609C02	3.8
Thyroid	TT	4.4
Upper aerodigestive tract	BHY	4
Upper aerodigestive tract	BICR16	4.4
Upper aerodigestive tract	BICR18	4.3
Upper aerodigestive tract	BICR22	4.4
Upper aerodigestive tract	BICR31	4.8
Upper aerodigestive tract	BICR56	4.1
Upper aerodigestive tract	BICR6	4.2
Upper aerodigestive tract	CAL27	5.1
Upper aerodigestive tract	CAL33	3.7
Upper aerodigestive tract	DETROIT562	6.2
Upper aerodigestive tract	FADU	4.3
Upper aerodigestive tract	HS840T	5.6
Upper aerodigestive tract	HSC2	4.4
Upper aerodigestive tract	HSC3	4.4
Upper aerodigestive tract	HSC4	3.9
Upper aerodigestive tract	PECAPJ15	3.9
Upper aerodigestive tract	PECAPJ34CLONEC12	4.1
Upper aerodigestive tract	PECAPJ41CLONED2	3.9
Upper aerodigestive tract	PECAPJ49	4.8
Upper aerodigestive tract	SCC15	4.1
Upper aerodigestive tract	SCC25	4.2
Upper aerodigestive tract	SCC4	5.2
Upper aerodigestive tract	SCC9	3.9
Upper aerodigestive tract	SNU1076	5.1
Upper aerodigestive tract	SNU1214	4
Upper aerodigestive tract	SNU46	4.2
Upper aerodigestive tract	SNU899	4.3
Upper aerodigestive tract	YD10B	4.5
Upper aerodigestive tract	YD38	6.6
Upper aerodigestive tract	YD8	4.3
Urinary tract	5637	3.9
Urinary tract	639V	3.8
Urinary tract	647V	5.3
Urinary tract	BC3C	4
Urinary tract	BFTC905	4.1
Urinary tract	CAL29	4.4
Urinary tract	HS172T	4.5
Urinary tract	HT1197	4.6
Urinary tract	HT1376	4
Urinary tract	J82	4.1
Urinary tract	JMSU1	3.9
Urinary tract	KMBC2	3.9
Urinary tract	KU1919	5.3
Urinary tract	RT11284	4
Urinary tract	RT112	3.9
Urinary tract	RT4	3.8
Urinary tract	SCABER	5.2
Urinary tract	SW1710	4
Urinary tract	SW780	3.9
Urinary tract	T24	3.9
Urinary tract	TCCSUP	3.6
Urinary tract	UMUC1	3.9
Urinary tract	UMUC3	4.4
Urinary tract	VMCUB1	4

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	0.7
Adrenal gland	0.9
Appendix	0.1
Bone marrow	0
Breast	0.2
Cerebral cortex	10.7
Cervix, uterine	5.1
Colon	0.2
Duodenum	0.2
Endometrium	0.2
Epididymis	0.2
Esophagus	0.6
Fallopian tube	3.4
Gallbladder	0.6
Heart muscle	4
Kidney	0.2
Liver	0
Lung	0.8
Lymph node	0.1
Ovary	0.4
Pancreas	0
Parathyroid gland	80.2
Placenta	0.1
Prostate	19.5
Rectum	0.3
Salivary gland	0.4
Seminal vesicle	6.2
Skeletal muscle	1
Skin	0.1
Small intestine	0.4
Smooth muscle	0.3
Spleen	0.3
Stomach	0.3
Testis	1.9
Thyroid gland	0.5
Tonsil	0.2
Urinary bladder	3.5

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
19901965	overexpression	Malignant Peripheral Nerve Sheath Tumor	We identified a decrease in DACH1 expression, and increases in the expressions of PAX6, EYA1, EYA2, EYA4, and SIX1-4 genes.
27082308	overexpression	Breast Carcinoma	Moreover, an increased expression of EYA1 was also found in breast cancer tissues and cell lines.
26370624	underexpression	Glioma	Proteins namely, SNX1, EYA1, PQBP1 and IGHG1 showed dysregulation across various grades.
24729159	underexpression	Gastric Carcinoma	The EYA1 expression decreased significantly in gastric tumor tissues compared with adjacent normal tissues.
23636126	overexpression	Breast Carcinoma	Herein, comparison with normal breast showed that EYA1 is overexpressed with cyclin D1 in luminal B breast cancer subtype.
18671248	overexpression	Neuroblastic Tumor	Five genes overexpressed in NTs-SP encode for nuclear proteins (CENPF, EYA1, PBK, TOP2A, TFAP2B), whereas only 1 of 11 highly expressed genes in NTs-SR encodes for a nuclear receptor (NR4A2).
12057921	overexpression	Kidney Wilms Tumor	Automated clustering identified a smaller group of 27 genes that were highly expressed in WTs compared to fetal kidney and heterologous tumor and normal tissues. This signature set was enriched in genes encoding transcription factors. Four of these, PAX2, EYA1, HBF2, and HOXA11, are essential for cell survival and proliferation in early metanephric development, whereas others, including SIX1, MOX1, and SALL2, are predicted to act at this stage.
27795300	overexpression	Breast Carcinoma	EYA1 is known to be overexpressed in human breast cancer, in which the Myc protein is also accumulated in association with decreased phospho-T58 (pT58) levels.

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.058	0.243	6.7	38.4	55	Gain
BRCA	Breast invasive carcinoma	1075	-0.018	0.549	4.6	40.7	54.8	Gain
CESC	Cervical and endocervical cancers	292	-0.069	0.237	7.5	60.3	32.2	Neutral
COAD	Colon adenocarcinoma	449	0.261	2.06e-08	2.9	43.4	53.7	Gain
ESCA	Esophageal carcinoma	183	0.074	0.321	8.7	33.3	57.9	Gain
GBM	Glioblastoma multiforme	147	0.153	0.0643	10.9	78.2	10.9	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.034	0.436	4.3	32.1	63.6	Gain
KIRC	Kidney renal clear cell carcinoma	525	0.301	1.83e-12	12.8	74.5	12.8	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.033	0.573	3.1	88.2	8.7	Neutral
LAML	Acute Myeloid Leukemia	166	0.009	0.913	0.6	87.3	12	Neutral
LGG	Brain Lower Grade Glioma	513	0.049	0.271	2.7	87.3	9.9	Neutral
LUAD	Lung adenocarcinoma	512	0.076	0.0863	9.2	39.3	51.6	Gain
LUSC	Lung squamous cell carcinoma	498	0.037	0.414	11.4	35.1	53.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.108	0.0613	13.3	31	55.7	Gain
PAAD	Pancreatic adenocarcinoma	177	0.113	0.135	8.5	63.8	27.7	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.09	0.256	7.4	83.3	9.3	Neutral
PRAD	Prostate adenocarcinoma	491	-0.224	5.5e-07	0.8	68.4	30.8	Neutral
READ	Rectum adenocarcinoma	164	0.214	0.00592	4.3	37.2	58.5	Gain
SARC	Sarcoma	255	0.213	0.000633	12.5	56.1	31.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.21	5.08e-05	6	46	48	Gain
STAD	Stomach adenocarcinoma	413	-0.006	0.909	6.1	36.1	57.9	Gain
TGCT	Testicular Germ Cell Tumors	150	0.205	0.0119	2	16	82	Gain
THCA	Thyroid carcinoma	497	0.097	0.031	0.8	97.8	1.4	Neutral
THYM	Thymoma	119	-0.367	4.11e-05	1.7	89.9	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.007	0.865	2.8	65	32.2	Neutral

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.041	0.404	17	408	-0.002	0.00088	NS/NA
BRCA	Breast invasive carcinoma	-0.114	0.000766	83	785	0.013	3.32e-27	NS/NA
CESC	Cervical and endocervical cancers	-0.413	3.08e-14	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.456	0	19	297	-0.007	7.14e-16	NS/NA
ESCA	Esophageal carcinoma	-0.264	0.000209	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.532	7.1e-06	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.265	4.51e-10	20	522	0.009	1.31e-08	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.171	0.00148	24	319	-0.01	0.0728	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.361	1.78e-10	23	275	-0.034	0.201	NS/NA
LAML	Acute Myeloid Leukemia	-0.091	0.236	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.55	0	0	530	NA	NA	NS/NA
LUAD	Lung adenocarcinoma	-0.244	7.15e-08	21	456	0	7.82e-06	NS/NA
LUSC	Lung squamous cell carcinoma	-0.153	0.00291	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.867	0.00451	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.354	1.01e-06	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.403	1.47e-08	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.294	5.91e-12	35	498	0.255	2.07e-15	Increased
READ	Rectum adenocarcinoma	-0.211	0.0346	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.305	5.02e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.384	0	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.181	0.000463	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.362	3.96e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.145	0.000612	50	509	0.023	0.303	NS/NA
THYM	Thymoma	-0.569	0	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.371	9.11e-17	34	431	-0.031	0.146	NS/NA

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.219	NS	24476821
BRCA	Breast invasive carcinoma	521	9.99e-08	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00246	Significant	22810696
GBM	Glioblastoma multiforme	157	3.33e-05	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.96e-11	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.000386	Significant	26536169
LGG	Brain Lower Grade Glioma	513	5.76e-30	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0249	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.658	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0375	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0146	Significant	26544944
READ	Rectum adenocarcinoma	67	0.288	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	1.78e-05	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.000837	Significant	25079317
THCA	Thyroid carcinoma	391	0.00175	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000477	Significant	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.756	0.00968	Shorter
BRCA	Breast invasive carcinoma	1079	1.119	0.618	NS
CESC	Cervical and endocervical cancers	291	1.023	0.945	NS
COAD	Colon adenocarcinoma	439	1.066	0.826	NS
ESCA	Esophageal carcinoma	184	0.674	0.243	NS
GBM	Glioblastoma multiforme	158	1.228	0.426	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.208	0.35	NS
KIRC	Kidney renal clear cell carcinoma	531	2.352	1.36e-05	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.402	0.412	NS
LAML	Acute Myeloid Leukemia	149	0.825	0.502	NS
LGG	Brain Lower Grade Glioma	511	0.413	0.000446	Longer
LUAD	Lung adenocarcinoma	502	1.024	0.908	NS
LUSC	Lung squamous cell carcinoma	494	0.903	0.6	NS
OV	Ovarian serous cystadenocarcinoma	303	0.689	0.0663	NS
PAAD	Pancreatic adenocarcinoma	177	0.997	0.994	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.46	0.517	NS
PRAD	Prostate adenocarcinoma	497	0.537	0.468	NS
READ	Rectum adenocarcinoma	159	0.747	0.594	NS
SARC	Sarcoma	259	0.875	0.626	NS
SKCM	Skin Cutaneous Melanoma	459	0.789	0.208	NS
STAD	Stomach adenocarcinoma	388	1.776	0.0163	Shorter
TGCT	Testicular Germ Cell Tumors	134	0	0.195	NS
THCA	Thyroid carcinoma	500	9.582	0.00868	Shorter
THYM	Thymoma	119	1.077	0.928	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.423	0.199	NS

> Stage

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Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.205	3.04e-05	Higher
BRCA	Breast invasive carcinoma	1071	0.042	0.166	NS
CESC	Cervical and endocervical cancers	167	0.15	0.0523	NS
COAD	Colon adenocarcinoma	445	0.061	0.199	NS
ESCA	Esophageal carcinoma	162	0.043	0.584	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.018	0.706	NS
KIRC	Kidney renal clear cell carcinoma	531	0.229	1e-07	Higher
KIRP	Kidney renal papillary cell carcinoma	260	-0.054	0.387	NS
LUAD	Lung adenocarcinoma	507	-0.024	0.589	NS
LUSC	Lung squamous cell carcinoma	497	-0.07	0.121	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.087	0.13	NS
PAAD	Pancreatic adenocarcinoma	176	-0.077	0.307	NS
READ	Rectum adenocarcinoma	156	0.022	0.787	NS
SKCM	Skin Cutaneous Melanoma	410	-0.037	0.456	NS
STAD	Stomach adenocarcinoma	392	0.096	0.0577	NS
TGCT	Testicular Germ Cell Tumors	81	0.166	0.139	NS
THCA	Thyroid carcinoma	499	0.054	0.231	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.096	0.0316	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.059	0.334	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.164	0.000232	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.168	0.000106	Higher
LGG	Brain Lower Grade Glioma	514	-0.256	3.67e-09	Lower
OV	Ovarian serous cystadenocarcinoma	296	-0.006	0.916	NS
PAAD	Pancreatic adenocarcinoma	176	-0.022	0.77	NS
STAD	Stomach adenocarcinoma	406	0.093	0.0608	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.059	0.173	NS

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for EYA1.

Summary
Symbol	EYA1
Name	EYA transcriptional coactivator and phosphatase 1
Aliases	eyes absent (Drosophila) homolog 1; eyes absent homolog 1 (Drosophila); Eyes absent homolog 1
Location	8q13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for EYA1.

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27082308	Breast Carcinoma	upstream	miR101	negative regulation	Western blot analysis demonstrated a significantly decreased protein level of EYA1 in the SKBR3 cells transfected with miR101 mimic, whereas transfection with miR101 inhibitor led to an increased level of EYA1.
27795300	Breast Carcinoma	downstream	Myc	positive regulation	In this study, we have investigated these questions, and here, we report that depletion of EYA1 using short hairpin RNA (shRNA) in breast cancer cells destabilizes the Myc protein and increases pT58 levels, leading to an increase in the doubling time and impairment of cell cycle progression.