CR2Cancer

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF10394 Histone acetyl transferase HAT1 N-terminus

Function

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone acetylation	H4, H2A	#	9427644

> Gene Ontology [ TOP ]
Biological Process	GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006335 DNA replication-dependent nucleosome assembly GO:0006336 DNA replication-independent nucleosome assembly GO:0006342 chromatin silencing GO:0006348 chromatin silencing at telomere GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0007584 response to nutrient GO:0009991 response to extracellular stimulus GO:0016458 gene silencing GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0031497 chromatin assembly GO:0031667 response to nutrient levels GO:0034723 DNA replication-dependent nucleosome organization GO:0034724 DNA replication-independent nucleosome organization GO:0034728 nucleosome organization GO:0040029 regulation of gene expression, epigenetic GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0045814 negative regulation of gene expression, epigenetic GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization
Molecular Function	GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0010485 H4 histone acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0034212 peptide N-acetyltransferase activity GO:0042393 histone binding GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component	GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0016363 nuclear matrix GO:0034399 nuclear periphery GO:0044454 nuclear chromosome part GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4689520	c.457G>A	p.G153R	Substitution - Missense	Large_intestine
COSM1401272	c.758G>A	p.G253D	Substitution - Missense	Large_intestine
COSM217218	c.717T>G	p.S239R	Substitution - Missense	Liver
COSM356095	c.592A>G	p.R198G	Substitution - Missense	Lung
COSM4387939	c.806C>T	p.T269I	Substitution - Missense	Pancreas
COSM4846827	c.1119G>A	p.M373I	Substitution - Missense	Cervix
COSM2893394	c.1224T>G	p.D408E	Substitution - Missense	Large_intestine
COSM1401271	c.569G>C	p.S190T	Substitution - Missense	Large_intestine
COSM4955608	c.233A>G	p.Y78C	Substitution - Missense	Liver
COSM3837416	c.618G>A	p.E206E	Substitution - coding silent	Breast
COSM4086769	c.1092G>T	p.K364N	Substitution - Missense	Stomach
COSM3757772	c.407T>C	p.F136S	Substitution - Missense	Large_intestine
COSM1325761	c.605T>G	p.F202C	Substitution - Missense	Ovary
COSM476223	c.341T>G	p.I114S	Substitution - Missense	Kidney
COSM4636026	c.552G>T	p.W184C	Substitution - Missense	Large_intestine
COSM4689523	c.1006C>T	p.R336*	Substitution - Nonsense	Large_intestine
COSM4086768	c.948G>T	p.E316D	Substitution - Missense	Stomach
COSM1009565	c.922G>T	p.G308*	Substitution - Nonsense	Endometrium
COSM4831391	c.1026G>A	p.M342I	Substitution - Missense	Cervix
COSM1190725	c.75delC	p.Y25fs*1	Deletion - Frameshift	Lung
COSM266657	c.1172T>C	p.I391T	Substitution - Missense	Large_intestine
COSM5934542	c.1136C>T	p.P379L	Substitution - Missense	Skin
COSM5964929	c.113T>C	p.V38A	Substitution - Missense	Breast
COSM3798181	c.857G>A	p.R286Q	Substitution - Missense	Urinary_tract
COSM4444750	c.116G>A	p.R39H	Substitution - Missense	Large_intestine
COSM5725710	c.842G>A	p.S281N	Substitution - Missense	Skin
COSM5834286	c.616delG	p.E206fs*14	Deletion - Frameshift	Breast
COSM33178	c.949G>C	p.A317P	Substitution - Missense	Large_intestine
COSM4086766	c.682T>C	p.Y228H	Substitution - Missense	Stomach
COSM5707866	c.395_396delAG	p.K132fs*3	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1009562	c.550T>C	p.W184R	Substitution - Missense	Endometrium
COSM1009561	c.294C>A	p.N98K	Substitution - Missense	Endometrium
COSM3798179	c.177C>G	p.L59L	Substitution - coding silent	Urinary_tract
COSM1009563	c.554T>G	p.F185C	Substitution - Missense	Endometrium
COSM1253970	c.1176C>T	p.S392S	Substitution - coding silent	Oesophagus
COSM5938000	c.189-8C>T	p.?	Unknown	Skin
COSM1009564	c.861C>A	p.D287E	Substitution - Missense	Endometrium
COSM4689521	c.519A>G	p.E173E	Substitution - coding silent	Large_intestine
COSM217218	c.717T>G	p.S239R	Substitution - Missense	Liver
COSM3379860	c.704G>A	p.R235Q	Substitution - Missense	Pancreas
COSM261225	c.417C>T	p.F139F	Substitution - coding silent	Large_intestine
COSM4689522	c.849G>C	p.V283V	Substitution - coding silent	Large_intestine
COSM4689518	c.177C>A	p.L59L	Substitution - coding silent	Large_intestine
COSM5982483	c.645C>T	p.L215L	Substitution - coding silent	Upper_aerodigestive_tract
COSM4955608	c.233A>G	p.Y78C	Substitution - Missense	Liver
COSM4086767	c.755A>G	p.H252R	Substitution - Missense	Stomach
COSM5624453	c.1228C>G	p.R410G	Substitution - Missense	Oesophagus
COSM3895356	c.158C>T	p.P53L	Substitution - Missense	Skin
COSM5982483	c.645C>T	p.L215L	Substitution - coding silent	Upper_aerodigestive_tract
COSM4442088	c.494A>G	p.D165G	Substitution - Missense	Large_intestine
COSM3743330	c.757G>C	p.G253R	Substitution - Missense	Liver
COSM4842682	c.742C>T	p.Q248*	Substitution - Nonsense	Cervix
COSM3570004	c.115C>T	p.R39C	Substitution - Missense	Skin
COSM1253969	c.835T>G	p.S279A	Substitution - Missense	Oesophagus
COSM3570005	c.902C>T	p.S301F	Substitution - Missense	Skin
COSM4305938	c.1073G>A	p.R358K	Substitution - Missense	Upper_aerodigestive_tract
COSM304376	c.152T>C	p.F51S	Substitution - Missense	Large_intestine
COSM5986098	c.434C>T	p.T145I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM74868	c.1034C>T	p.A345V	Substitution - Missense	Ovary
COSM5614977	c.347C>A	p.P116Q	Substitution - Missense	Lung
COSM4689519	c.248T>C	p.L83P	Substitution - Missense	Large_intestine
COSM1009566	c.975G>T	p.K325N	Substitution - Missense	Endometrium
COSM1401270	c.249G>A	p.L83L	Substitution - coding silent	Large_intestine
COSM717731	c.1053C>G	p.Y351*	Substitution - Nonsense	Lung
COSM717733	c.535C>T	p.Q179*	Substitution - Nonsense	Lung
COSM5802215	c.89_90delAC	p.T31fs*3	Deletion - Frameshift	Breast
COSM217218	c.717T>G	p.S239R	Substitution - Missense	Liver
COSM3798180	c.607C>G	p.L203V	Substitution - Missense	Urinary_tract
COSM5017419	c.815A>T	p.D272V	Substitution - Missense	Soft_tissue
COSM5982483	c.645C>T	p.L215L	Substitution - coding silent	Upper_aerodigestive_tract
COSM1401269	c.106A>C	p.K36Q	Substitution - Missense	Large_intestine
COSM4086765	c.470T>G	p.F157C	Substitution - Missense	Stomach
COSM4653364	c.709C>T	p.R237C	Substitution - Missense	Large_intestine
COSM1737571	c.823+1G>A	p.?	Unknown	Central_nervous_system
COSM213853	c.502T>C	p.C168R	Substitution - Missense	Breast
COSM236752	c.272A>T	p.Y91F	Substitution - Missense	Prostate
COSM5058254	c.244A>G	p.S82G	Substitution - Missense	Stomach
COSM2893392	c.1053C>T	p.Y351Y	Substitution - coding silent	Large_intestine
COSM1401273	c.905G>A	p.R302Q	Substitution - Missense	Large_intestine
COSM5725710	c.842G>A	p.S281N	Substitution - Missense	Skin

> Text Mining based Variations [ TOP ]
There is no record for HAT1.

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O14929	9	K	N6-acetyllysine	-	No	None detected
O14929	15	K	N6-acetyllysine	-	No	None detected
O14929	343	S	Phosphoserine	-	No	None detected

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.499	5.526	0.034	0.855	NS
BRCA	Breast invasive carcinoma	112	1100	5.576	5.959	0.351	8.21e-14	NS
CESC	Cervical and endocervical cancers	3	306	5.358	6.216	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.134	5.509	0.295	0.00252	NS
ESCA	Esophageal carcinoma	11	185	5.152	5.677	0.555	0.00302	NS
GBM	Glioblastoma multiforme	5	166	4.157	5.747	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.398	5.704	0.359	3.96e-06	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.333	5.208	-0.172	0.00105	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.109	4.947	-0.205	0.0513	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.836	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.17	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.182	4.418	0.225	0.00587	NS
LUAD	Lung adenocarcinoma	59	517	5.143	5.353	0.178	0.00731	NS
LUSC	Lung squamous cell carcinoma	51	501	5.166	5.974	0.8	6.54e-27	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.651	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.962	5.024	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.418	4.94	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.497	5.675	0.218	0.000673	NS
READ	Rectum adenocarcinoma	10	167	5.473	5.487	-0.049	0.85	NS
SARC	Sarcoma	2	263	5.375	5.363	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.791	5.522	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.104	5.454	0.328	0.000148	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.164	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.447	5.398	-0.112	0.042	NS
THYM	Thymoma	2	120	5.517	5.705	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.05	5.286	0.135	0.326	NS

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.2
Autonomic ganglia	CHP212	10.8
Autonomic ganglia	IMR32	10.7
Autonomic ganglia	KELLY	11.3
Autonomic ganglia	KPNRTBM1	10.1
Autonomic ganglia	KPNSI9S	11.1
Autonomic ganglia	KPNYN	10.2
Autonomic ganglia	MHHNB11	9.5
Autonomic ganglia	NB1	10.9
Autonomic ganglia	NH6	10.2
Autonomic ganglia	SHSY5Y	10.1
Autonomic ganglia	SIMA	10.3
Autonomic ganglia	SKNAS	10.8
Autonomic ganglia	SKNBE2	10.4
Autonomic ganglia	SKNDZ	11.3
Autonomic ganglia	SKNFI	10.9
Autonomic ganglia	SKNSH	10.9
Biliary tract	HUCCT1	11.4
Biliary tract	HUH28	10.7
Biliary tract	SNU1079	10.5
Biliary tract	SNU1196	10.8
Biliary tract	SNU245	10.9
Biliary tract	SNU308	10.9
Biliary tract	SNU478	11.3
Bone	143B	11.9
Bone	A673	11.6
Bone	CADOES1	9.6
Bone	CAL78	11
Bone	G292CLONEA141B1	11.6
Bone	HOS	11.8
Bone	HS706T	11
Bone	HS737T	10.4
Bone	HS819T	10.4
Bone	HS821T	10.8
Bone	HS822T	10.1
Bone	HS863T	11
Bone	HS870T	11.6
Bone	HS888T	10.6
Bone	MG63	11.7
Bone	MHHES1	11
Bone	OUMS27	11.2
Bone	RDES	11
Bone	SJSA1	11.4
Bone	SKES1	11.5
Bone	SKNMC	11.4
Bone	SW1353	10.8
Bone	T173	10.8
Bone	TC71	11.7
Bone	U2OS	11.6
Breast	AU565	10.9
Breast	BT20	11.8
Breast	BT474	10.9
Breast	BT483	10.1
Breast	BT549	11.2
Breast	CAL120	10.9
Breast	CAL148	10.5
Breast	CAL51	11.4
Breast	CAL851	10.9
Breast	CAMA1	11.4
Breast	DU4475	11.7
Breast	EFM192A	11.3
Breast	EFM19	10.8
Breast	EVSAT	10.7
Breast	HCC1143	11.1
Breast	HCC1187	10.8
Breast	HCC1395	11.9
Breast	HCC1419	11
Breast	HCC1428	11.2
Breast	HCC1500	10.9
Breast	HCC1569	11.1
Breast	HCC1599	11.2
Breast	HCC1806	10.4
Breast	HCC1937	11.7
Breast	HCC1954	11.6
Breast	HCC202	11.3
Breast	HCC2157	10.6
Breast	HCC2218	10.6
Breast	HCC38	11.6
Breast	HCC70	11.4
Breast	HDQP1	10.8
Breast	HMC18	11.4
Breast	HS274T	10.6
Breast	HS281T	10.7
Breast	HS343T	11
Breast	HS578T	11.3
Breast	HS606T	10.4
Breast	HS739T	10.5
Breast	HS742T	10.5
Breast	JIMT1	10.7
Breast	KPL1	11.4
Breast	MCF7	11.5
Breast	MDAMB134VI	11.8
Breast	MDAMB157	12
Breast	MDAMB175VII	10.4
Breast	MDAMB231	11.6
Breast	MDAMB361	11.3
Breast	MDAMB415	10.8
Breast	MDAMB436	11.8
Breast	MDAMB453	11.9
Breast	MDAMB468	11.7
Breast	SKBR3	10.7
Breast	T47D	11.3
Breast	UACC812	9.3
Breast	UACC893	11.4
Breast	YMB1	10.3
Breast	ZR751	11.6
Breast	ZR7530	11.1
Central nervous system	1321N1	11.6
Central nervous system	42MGBA	11.7
Central nervous system	8MGBA	11.4
Central nervous system	A172	11.5
Central nervous system	AM38	11.4
Central nervous system	BECKER	11.6
Central nervous system	CAS1	10.8
Central nervous system	CCFSTTG1	11.6
Central nervous system	D283MED	10.8
Central nervous system	D341MED	9.7
Central nervous system	DAOY	11.4
Central nervous system	DBTRG05MG	10.4
Central nervous system	DKMG	11.2
Central nervous system	GAMG	11.6
Central nervous system	GB1	11.1
Central nervous system	GI1	11.1
Central nervous system	GMS10	10.6
Central nervous system	GOS3	11.1
Central nervous system	H4	11
Central nervous system	HS683	11.2
Central nervous system	KALS1	10.8
Central nervous system	KG1C	10.8
Central nervous system	KNS42	12
Central nervous system	KNS60	11
Central nervous system	KNS81	11
Central nervous system	KS1	11.9
Central nervous system	LN18	11.4
Central nervous system	LN229	11.6
Central nervous system	M059K	11
Central nervous system	MOGGCCM	10.7
Central nervous system	MOGGUVW	11.6
Central nervous system	NMCG1	11.3
Central nervous system	ONS76	10.8
Central nervous system	SF126	11.6
Central nervous system	SF295	11.1
Central nervous system	SNB19	11.8
Central nervous system	SNU1105	11.1
Central nervous system	SNU201	10.3
Central nervous system	SNU466	10
Central nervous system	SNU489	9.3
Central nervous system	SNU626	11.3
Central nervous system	SNU738	11
Central nervous system	SW1088	11.7
Central nervous system	SW1783	11.3
Central nervous system	T98G	11.3
Central nervous system	TM31	10.5
Central nervous system	U118MG	11.4
Central nervous system	U138MG	11.2
Central nervous system	U251MG	11.2
Central nervous system	U87MG	11.3
Central nervous system	YH13	11
Central nervous system	YKG1	11.2
Endometrium	AN3CA	11.7
Endometrium	COLO684	10.7
Endometrium	EFE184	10.2
Endometrium	EN	11.3
Endometrium	ESS1	11.5
Endometrium	HEC108	10.7
Endometrium	HEC151	11.6
Endometrium	HEC1A	11.7
Endometrium	HEC1B	11.2
Endometrium	HEC251	11.8
Endometrium	HEC265	11.4
Endometrium	HEC50B	11.8
Endometrium	HEC59	11.7
Endometrium	HEC6	12
Endometrium	ISHIKAWAHERAKLIO02ER	11.3
Endometrium	JHUEM1	11
Endometrium	JHUEM2	11.8
Endometrium	JHUEM3	10.8
Endometrium	KLE	11
Endometrium	MFE280	10.8
Endometrium	MFE296	12.2
Endometrium	MFE319	11.2
Endometrium	RL952	11.2
Endometrium	SNGM	10.2
Endometrium	SNU1077	10.3
Endometrium	SNU685	10.8
Endometrium	TEN	10.9
Haematopoietic and lymphoid	697	11.4
Haematopoietic and lymphoid	A3KAW	11.4
Haematopoietic and lymphoid	A4FUK	11.4
Haematopoietic and lymphoid	ALLSIL	11.1
Haematopoietic and lymphoid	AML193	11.5
Haematopoietic and lymphoid	AMO1	11.7
Haematopoietic and lymphoid	BCP1	11.3
Haematopoietic and lymphoid	BDCM	11.4
Haematopoietic and lymphoid	BL41	11.7
Haematopoietic and lymphoid	BL70	12
Haematopoietic and lymphoid	BV173	10.7
Haematopoietic and lymphoid	CA46	10.9
Haematopoietic and lymphoid	CI1	12
Haematopoietic and lymphoid	CMK115	11.4
Haematopoietic and lymphoid	CMK86	11.1
Haematopoietic and lymphoid	CMK	10.8
Haematopoietic and lymphoid	CMLT1	11.1
Haematopoietic and lymphoid	COLO775	11.4
Haematopoietic and lymphoid	DAUDI	11.4
Haematopoietic and lymphoid	DB	11.2
Haematopoietic and lymphoid	DEL	10.8
Haematopoietic and lymphoid	DND41	11.2
Haematopoietic and lymphoid	DOHH2	11.2
Haematopoietic and lymphoid	EB1	11
Haematopoietic and lymphoid	EB2	10.8
Haematopoietic and lymphoid	EHEB	10.8
Haematopoietic and lymphoid	EJM	11
Haematopoietic and lymphoid	EM2	11.4
Haematopoietic and lymphoid	EOL1	10.9
Haematopoietic and lymphoid	F36P	11.1
Haematopoietic and lymphoid	GA10	11.6
Haematopoietic and lymphoid	GDM1	11.3
Haematopoietic and lymphoid	GRANTA519	11
Haematopoietic and lymphoid	HDLM2	11.1
Haematopoietic and lymphoid	HDMYZ	11.3
Haematopoietic and lymphoid	HEL9217	11.6
Haematopoietic and lymphoid	HEL	11.3
Haematopoietic and lymphoid	HH	11.7
Haematopoietic and lymphoid	HL60	10.8
Haematopoietic and lymphoid	HPBALL	11.1
Haematopoietic and lymphoid	HS604T	10.1
Haematopoietic and lymphoid	HS611T	11.9
Haematopoietic and lymphoid	HS616T	10.5
Haematopoietic and lymphoid	HS751T	11
Haematopoietic and lymphoid	HT	12.2
Haematopoietic and lymphoid	HTK	11.5
Haematopoietic and lymphoid	HUNS1	11.5
Haematopoietic and lymphoid	HUT102	11
Haematopoietic and lymphoid	HUT78	10.6
Haematopoietic and lymphoid	JEKO1	10.8
Haematopoietic and lymphoid	JK1	10.6
Haematopoietic and lymphoid	JM1	11.3
Haematopoietic and lymphoid	JURKAT	11.2
Haematopoietic and lymphoid	JURLMK1	11.8
Haematopoietic and lymphoid	JVM2	10.5
Haematopoietic and lymphoid	JVM3	9.7
Haematopoietic and lymphoid	K562	12.2
Haematopoietic and lymphoid	KARPAS299	11.5
Haematopoietic and lymphoid	KARPAS422	11.3
Haematopoietic and lymphoid	KARPAS620	10.6
Haematopoietic and lymphoid	KASUMI1	11.4
Haematopoietic and lymphoid	KASUMI2	11.2
Haematopoietic and lymphoid	KASUMI6	11.2
Haematopoietic and lymphoid	KCL22	11.6
Haematopoietic and lymphoid	KE37	11.4
Haematopoietic and lymphoid	KE97	12
Haematopoietic and lymphoid	KG1	11.6
Haematopoietic and lymphoid	KHM1B	11.1
Haematopoietic and lymphoid	KIJK	12
Haematopoietic and lymphoid	KMH2	11.5
Haematopoietic and lymphoid	KMM1	11.3
Haematopoietic and lymphoid	KMS11	11.3
Haematopoietic and lymphoid	KMS12BM	11.2
Haematopoietic and lymphoid	KMS18	11.3
Haematopoietic and lymphoid	KMS20	11
Haematopoietic and lymphoid	KMS21BM	11
Haematopoietic and lymphoid	KMS26	11.7
Haematopoietic and lymphoid	KMS27	11.2
Haematopoietic and lymphoid	KMS28BM	10.1
Haematopoietic and lymphoid	KMS34	11.1
Haematopoietic and lymphoid	KO52	11.1
Haematopoietic and lymphoid	KOPN8	10.9
Haematopoietic and lymphoid	KU812	10.6
Haematopoietic and lymphoid	KYO1	11.4
Haematopoietic and lymphoid	L1236	11.3
Haematopoietic and lymphoid	L363	11.9
Haematopoietic and lymphoid	L428	11.9
Haematopoietic and lymphoid	L540	11.4
Haematopoietic and lymphoid	LAMA84	10.5
Haematopoietic and lymphoid	LOUCY	11.6
Haematopoietic and lymphoid	LP1	9.7
Haematopoietic and lymphoid	M07E	11.1
Haematopoietic and lymphoid	MC116	12.1
Haematopoietic and lymphoid	ME1	11.5
Haematopoietic and lymphoid	MEC1	11.3
Haematopoietic and lymphoid	MEC2	11.2
Haematopoietic and lymphoid	MEG01	10.9
Haematopoietic and lymphoid	MHHCALL2	11.1
Haematopoietic and lymphoid	MHHCALL3	11.3
Haematopoietic and lymphoid	MHHCALL4	10.9
Haematopoietic and lymphoid	MINO	11.6
Haematopoietic and lymphoid	MJ	11.6
Haematopoietic and lymphoid	MM1S	11.5
Haematopoietic and lymphoid	MOLM13	11.5
Haematopoietic and lymphoid	MOLM16	11.3
Haematopoietic and lymphoid	MOLM6	10.4
Haematopoietic and lymphoid	MOLP2	10.1
Haematopoietic and lymphoid	MOLP8	10.6
Haematopoietic and lymphoid	MOLT13	11.4
Haematopoietic and lymphoid	MOLT16	10.7
Haematopoietic and lymphoid	MOLT4	12
Haematopoietic and lymphoid	MONOMAC1	11.4
Haematopoietic and lymphoid	MONOMAC6	11.6
Haematopoietic and lymphoid	MOTN1	10.8
Haematopoietic and lymphoid	MUTZ5	11
Haematopoietic and lymphoid	MV411	11.6
Haematopoietic and lymphoid	NALM19	11.1
Haematopoietic and lymphoid	NALM1	11
Haematopoietic and lymphoid	NALM6	11.4
Haematopoietic and lymphoid	NAMALWA	11.4
Haematopoietic and lymphoid	NB4	11.9
Haematopoietic and lymphoid	NCIH929	11.3
Haematopoietic and lymphoid	NCO2	11.4
Haematopoietic and lymphoid	NOMO1	11.2
Haematopoietic and lymphoid	NUDHL1	9.7
Haematopoietic and lymphoid	NUDUL1	11.1
Haematopoietic and lymphoid	OCIAML2	11.2
Haematopoietic and lymphoid	OCIAML3	10.5
Haematopoietic and lymphoid	OCIAML5	11
Haematopoietic and lymphoid	OCILY10	12
Haematopoietic and lymphoid	OCILY19	10.4
Haematopoietic and lymphoid	OCILY3	11.6
Haematopoietic and lymphoid	OCIM1	11.3
Haematopoietic and lymphoid	OPM2	10.4
Haematopoietic and lymphoid	P12ICHIKAWA	11.2
Haematopoietic and lymphoid	P31FUJ	11.3
Haematopoietic and lymphoid	P3HR1	11.7
Haematopoietic and lymphoid	PCM6	10.2
Haematopoietic and lymphoid	PEER	12.1
Haematopoietic and lymphoid	PF382	11.4
Haematopoietic and lymphoid	PFEIFFER	11.4
Haematopoietic and lymphoid	PL21	11.2
Haematopoietic and lymphoid	RAJI	11.6
Haematopoietic and lymphoid	RCHACV	11.2
Haematopoietic and lymphoid	REC1	10.7
Haematopoietic and lymphoid	REH	11.6
Haematopoietic and lymphoid	RI1	11.2
Haematopoietic and lymphoid	RL	12.1
Haematopoietic and lymphoid	RPMI8226	11.1
Haematopoietic and lymphoid	RPMI8402	10.9
Haematopoietic and lymphoid	RS411	11.2
Haematopoietic and lymphoid	SEM	11.3
Haematopoietic and lymphoid	SET2	10.8
Haematopoietic and lymphoid	SIGM5	11.8
Haematopoietic and lymphoid	SKM1	11.6
Haematopoietic and lymphoid	SKMM2	10.7
Haematopoietic and lymphoid	SR786	11.6
Haematopoietic and lymphoid	ST486	11.6
Haematopoietic and lymphoid	SUDHL10	11.2
Haematopoietic and lymphoid	SUDHL1	11.5
Haematopoietic and lymphoid	SUDHL4	10.8
Haematopoietic and lymphoid	SUDHL5	12.3
Haematopoietic and lymphoid	SUDHL6	11.6
Haematopoietic and lymphoid	SUDHL8	11.3
Haematopoietic and lymphoid	SUPB15	11.5
Haematopoietic and lymphoid	SUPHD1	10.6
Haematopoietic and lymphoid	SUPM2	11.7
Haematopoietic and lymphoid	SUPT11	11.3
Haematopoietic and lymphoid	SUPT1	11.7
Haematopoietic and lymphoid	TALL1	11.6
Haematopoietic and lymphoid	TF1	11.4
Haematopoietic and lymphoid	THP1	11.5
Haematopoietic and lymphoid	TO175T	10.8
Haematopoietic and lymphoid	TOLEDO	11.5
Haematopoietic and lymphoid	U266B1	11
Haematopoietic and lymphoid	U937	12.7
Haematopoietic and lymphoid	UT7	10.7
Haematopoietic and lymphoid	WSUDLCL2	11.1
Kidney	769P	11.5
Kidney	786O	11.2
Kidney	A498	11.3
Kidney	A704	11.7
Kidney	ACHN	11.3
Kidney	BFTC909	11
Kidney	CAKI1	10.9
Kidney	CAKI2	11.1
Kidney	CAL54	10.6
Kidney	KMRC1	11.7
Kidney	KMRC20	11.3
Kidney	KMRC2	11.3
Kidney	KMRC3	10.3
Kidney	OSRC2	11
Kidney	RCC10RGB	10.7
Kidney	SNU1272	10.5
Kidney	SNU349	10.6
Kidney	TUHR10TKB	11
Kidney	TUHR14TKB	10.2
Kidney	TUHR4TKB	10.2
Kidney	VMRCRCW	11.1
Kidney	VMRCRCZ	11.1
Large intestine	C2BBE1	11.6
Large intestine	CCK81	11.7
Large intestine	CL11	11.2
Large intestine	CL14	10.5
Large intestine	CL34	11.1
Large intestine	CL40	10.5
Large intestine	COLO205	11.7
Large intestine	COLO320	11.5
Large intestine	COLO678	10.8
Large intestine	CW2	11
Large intestine	DLD1	12.1
Large intestine	GP2D	11.4
Large intestine	HCC56	10.7
Large intestine	HCT116	11.5
Large intestine	HCT15	11.8
Large intestine	HS675T	10.3
Large intestine	HS698T	10.7
Large intestine	HT115	11.3
Large intestine	HT29	11.6
Large intestine	HT55	10.7
Large intestine	KM12	12
Large intestine	LOVO	11.1
Large intestine	LS1034	10.9
Large intestine	LS123	10.4
Large intestine	LS180	11
Large intestine	LS411N	11.5
Large intestine	LS513	11
Large intestine	MDST8	10.8
Large intestine	NCIH508	9.7
Large intestine	NCIH716	11.5
Large intestine	NCIH747	11.4
Large intestine	OUMS23	11.5
Large intestine	RCM1	10.3
Large intestine	RKO	12.4
Large intestine	SKCO1	10.6
Large intestine	SNU1040	10.9
Large intestine	SNU1197	10.6
Large intestine	SNU175	10.7
Large intestine	SNU283	11.2
Large intestine	SNU407	10.8
Large intestine	SNU503	10.7
Large intestine	SNU61	11.2
Large intestine	SNU81	10.3
Large intestine	SNUC1	10.9
Large intestine	SNUC2A	11.3
Large intestine	SNUC4	11.3
Large intestine	SNUC5	11.3
Large intestine	SW1116	10.6
Large intestine	SW1417	11.6
Large intestine	SW1463	11.2
Large intestine	SW403	11.4
Large intestine	SW480	11.8
Large intestine	SW48	11.1
Large intestine	SW620	11.5
Large intestine	SW837	11.4
Large intestine	SW948	11.4
Large intestine	T84	11.1
Liver	ALEXANDERCELLS	11.1
Liver	C3A	11.4
Liver	HEP3B217	11.2
Liver	HEPG2	11.1
Liver	HLE	11.4
Liver	HLF	11.1
Liver	HUH1	11.6
Liver	HUH6	11.3
Liver	HUH7	11.5
Liver	JHH1	10.9
Liver	JHH2	11.1
Liver	JHH4	11.2
Liver	JHH5	11.1
Liver	JHH6	11.9
Liver	JHH7	11.6
Liver	LI7	11.1
Liver	PLCPRF5	11.2
Liver	SKHEP1	11.1
Liver	SNU182	11.6
Liver	SNU387	11.5
Liver	SNU398	12
Liver	SNU423	11.5
Liver	SNU449	11
Liver	SNU475	11.4
Liver	SNU761	10.1
Liver	SNU878	12.3
Liver	SNU886	11.5
Lung	A549	11.3
Lung	ABC1	11.8
Lung	BEN	10.5
Lung	CAL12T	11.2
Lung	CALU1	11.4
Lung	CALU3	11
Lung	CALU6	11.5
Lung	CHAGOK1	11.8
Lung	COLO668	10.7
Lung	COLO699	11.3
Lung	CORL105	10.9
Lung	CORL23	11.1
Lung	CORL24	11
Lung	CORL279	11
Lung	CORL311	10.6
Lung	CORL47	10.7
Lung	CORL51	11
Lung	CORL88	11.1
Lung	CORL95	10.5
Lung	CPCN	11.2
Lung	DMS114	11.2
Lung	DMS153	11.7
Lung	DMS273	10.6
Lung	DMS454	11.2
Lung	DMS53	12
Lung	DMS79	11.5
Lung	DV90	11.3
Lung	EBC1	11.5
Lung	EPLC272H	11.7
Lung	HARA	11.8
Lung	HCC1171	11.1
Lung	HCC1195	11
Lung	HCC15	11.3
Lung	HCC2279	11.3
Lung	HCC2935	11.3
Lung	HCC33	10.4
Lung	HCC366	11.9
Lung	HCC4006	11.7
Lung	HCC44	10.7
Lung	HCC78	10.6
Lung	HCC827	11.3
Lung	HCC95	11
Lung	HLC1	10.5
Lung	HLFA	10.6
Lung	HS229T	11.6
Lung	HS618T	11.2
Lung	IALM	10.6
Lung	KNS62	10.7
Lung	LC1F	11.4
Lung	LC1SQSF	11.5
Lung	LCLC103H	10.7
Lung	LCLC97TM1	10.6
Lung	LK2	11.6
Lung	LOUNH91	11.2
Lung	LU65	11.7
Lung	LU99	11.6
Lung	LUDLU1	11.5
Lung	LXF289	10.7
Lung	MORCPR	11.4
Lung	NCIH1048	11.5
Lung	NCIH1092	11.1
Lung	NCIH1105	11.5
Lung	NCIH1155	12
Lung	NCIH1184	11.6
Lung	NCIH1299	11.8
Lung	NCIH1339	11.1
Lung	NCIH1341	11.3
Lung	NCIH1355	11.4
Lung	NCIH1373	11
Lung	NCIH1385	11
Lung	NCIH1395	10.7
Lung	NCIH1435	11.7
Lung	NCIH1436	11.9
Lung	NCIH1437	10.8
Lung	NCIH146	10.9
Lung	NCIH1563	10.9
Lung	NCIH1568	11.1
Lung	NCIH1573	10.7
Lung	NCIH1581	11.1
Lung	NCIH1618	11.2
Lung	NCIH1623	11.4
Lung	NCIH1648	10.7
Lung	NCIH1650	11.4
Lung	NCIH1651	11.5
Lung	NCIH1666	10.3
Lung	NCIH1693	12.2
Lung	NCIH1694	11.3
Lung	NCIH1703	11.9
Lung	NCIH1734	11.3
Lung	NCIH1755	11.7
Lung	NCIH1781	11.2
Lung	NCIH1792	11
Lung	NCIH1793	11.7
Lung	NCIH1836	11.3
Lung	NCIH1838	10.9
Lung	NCIH1869	10.8
Lung	NCIH1876	11
Lung	NCIH1915	12.2
Lung	NCIH1930	11.6
Lung	NCIH1944	11.4
Lung	NCIH1963	11.6
Lung	NCIH196	11.3
Lung	NCIH1975	11
Lung	NCIH2009	11.6
Lung	NCIH2023	11
Lung	NCIH2029	10.9
Lung	NCIH2030	11.6
Lung	NCIH2066	11.7
Lung	NCIH2081	11.2
Lung	NCIH2085	11.4
Lung	NCIH2087	11.5
Lung	NCIH209	11.4
Lung	NCIH2106	11.3
Lung	NCIH2110	11.5
Lung	NCIH211	11.7
Lung	NCIH2122	10.8
Lung	NCIH2126	10.3
Lung	NCIH2141	11
Lung	NCIH2170	11.5
Lung	NCIH2171	11
Lung	NCIH2172	11.7
Lung	NCIH2196	11.8
Lung	NCIH2227	12.1
Lung	NCIH2228	11.3
Lung	NCIH226	11.6
Lung	NCIH2286	11.4
Lung	NCIH2291	11.2
Lung	NCIH2342	12
Lung	NCIH2347	11.4
Lung	NCIH23	12
Lung	NCIH2405	11.1
Lung	NCIH2444	11.2
Lung	NCIH292	11.1
Lung	NCIH322	11.3
Lung	NCIH3255	11.4
Lung	NCIH358	11.4
Lung	NCIH441	10.8
Lung	NCIH446	11.3
Lung	NCIH460	11.5
Lung	NCIH510	12.2
Lung	NCIH520	11.7
Lung	NCIH522	11.2
Lung	NCIH524	11
Lung	NCIH526	11.5
Lung	NCIH596	11.1
Lung	NCIH647	11.7
Lung	NCIH650	10.9
Lung	NCIH661	12.2
Lung	NCIH69	10.7
Lung	NCIH727	11.2
Lung	NCIH810	11.7
Lung	NCIH82	11.8
Lung	NCIH838	12.7
Lung	NCIH841	11.8
Lung	NCIH854	9.7
Lung	NCIH889	11.1
Lung	PC14	12.1
Lung	RERFLCAD1	11.1
Lung	RERFLCAD2	11.3
Lung	RERFLCAI	11.8
Lung	RERFLCKJ	11.3
Lung	RERFLCMS	11.6
Lung	RERFLCSQ1	11.5
Lung	SBC5	11.6
Lung	SCLC21H	10.9
Lung	SHP77	10.6
Lung	SKLU1	10.8
Lung	SKMES1	11.9
Lung	SQ1	11.5
Lung	SW1271	11.6
Lung	SW1573	11.1
Lung	SW900	11.3
Lung	VMRCLCD	11.3
Lung	VMRCLCP	11.1
Oesophagus	COLO680N	11.1
Oesophagus	ECGI10	10.8
Oesophagus	KYSE140	11.3
Oesophagus	KYSE150	11.4
Oesophagus	KYSE180	11.3
Oesophagus	KYSE270	10.7
Oesophagus	KYSE30	10.3
Oesophagus	KYSE410	11.5
Oesophagus	KYSE450	11.2
Oesophagus	KYSE510	11.7
Oesophagus	KYSE520	11.8
Oesophagus	KYSE70	10.4
Oesophagus	OE19	11.2
Oesophagus	OE33	11.7
Oesophagus	TE10	10.3
Oesophagus	TE11	11.7
Oesophagus	TE14	11.1
Oesophagus	TE15	11.4
Oesophagus	TE1	11.6
Oesophagus	TE4	10.9
Oesophagus	TE5	11.2
Oesophagus	TE6	11.2
Oesophagus	TE8	11.3
Oesophagus	TE9	11.2
Oesophagus	TT	11.9
Ovary	59M	11.4
Ovary	A2780	12.4
Ovary	CAOV3	11.6
Ovary	CAOV4	11
Ovary	COLO704	11.6
Ovary	COV318	10.9
Ovary	COV362	11.6
Ovary	COV434	11.2
Ovary	COV504	11.1
Ovary	COV644	11.2
Ovary	EFO21	10.4
Ovary	EFO27	11
Ovary	ES2	11.7
Ovary	FUOV1	10.9
Ovary	HEYA8	11.7
Ovary	HS571T	10.2
Ovary	IGROV1	10.6
Ovary	JHOC5	10.9
Ovary	JHOM1	10.2
Ovary	JHOM2B	10.8
Ovary	JHOS2	12.1
Ovary	JHOS4	11.7
Ovary	KURAMOCHI	11
Ovary	MCAS	11.7
Ovary	NIHOVCAR3	11.1
Ovary	OAW28	10.7
Ovary	OAW42	10.9
Ovary	OC314	11.3
Ovary	OC316	11.5
Ovary	ONCODG1	11
Ovary	OV56	10.6
Ovary	OV7	11.2
Ovary	OV90	10.2
Ovary	OVCAR4	11.1
Ovary	OVCAR8	11.3
Ovary	OVISE	10.5
Ovary	OVK18	10.7
Ovary	OVKATE	12.1
Ovary	OVMANA	10.6
Ovary	OVSAHO	10.8
Ovary	OVTOKO	11.4
Ovary	RMGI	10.1
Ovary	RMUGS	11.4
Ovary	SKOV3	11.2
Ovary	SNU119	11.7
Ovary	SNU840	10.8
Ovary	SNU8	11.3
Ovary	TOV112D	11.5
Ovary	TOV21G	10.9
Ovary	TYKNU	11.8
Pancreas	ASPC1	10
Pancreas	BXPC3	10.9
Pancreas	CAPAN1	10.4
Pancreas	CAPAN2	11
Pancreas	CFPAC1	10.6
Pancreas	DANG	11.4
Pancreas	HPAC	10.4
Pancreas	HPAFII	10.7
Pancreas	HS766T	11
Pancreas	HUPT3	11
Pancreas	HUPT4	11.2
Pancreas	KCIMOH1	11.4
Pancreas	KLM1	11
Pancreas	KP2	11.6
Pancreas	KP3	11
Pancreas	KP4	11.8
Pancreas	L33	11.1
Pancreas	MIAPACA2	11
Pancreas	PANC0203	11
Pancreas	PANC0213	10.5
Pancreas	PANC0327	11.1
Pancreas	PANC0403	11.3
Pancreas	PANC0504	11.1
Pancreas	PANC0813	11.5
Pancreas	PANC1005	11.5
Pancreas	PANC1	11.7
Pancreas	PATU8902	11.5
Pancreas	PATU8988S	11.3
Pancreas	PATU8988T	11.7
Pancreas	PK1	11.8
Pancreas	PK45H	11.5
Pancreas	PK59	10.1
Pancreas	PL45	11.5
Pancreas	PSN1	10.8
Pancreas	QGP1	11.2
Pancreas	SNU213	11
Pancreas	SNU324	10.8
Pancreas	SNU410	10.6
Pancreas	SU8686	10.4
Pancreas	SUIT2	11.5
Pancreas	SW1990	12.2
Pancreas	T3M4	10.8
Pancreas	TCCPAN2	10.9
Pancreas	YAPC	11.1
Pleura	ACCMESO1	12.4
Pleura	DM3	9.7
Pleura	ISTMES1	11.4
Pleura	ISTMES2	11.6
Pleura	JL1	10.9
Pleura	MPP89	11.5
Pleura	MSTO211H	11.7
Pleura	NCIH2052	11.3
Pleura	NCIH2452	11.5
Pleura	NCIH28	11.5
Prostate	22RV1	10.9
Prostate	DU145	11.2
Prostate	LNCAPCLONEFGC	11.4
Prostate	MDAPCA2B	11.2
Prostate	NCIH660	10.9
Prostate	PC3	11.4
Prostate	VCAP	11.3
Salivary gland	A253	11.8
Salivary gland	YD15	11.8
Skin	A101D	11.5
Skin	A2058	11.3
Skin	A375	11.2
Skin	C32	11.2
Skin	CHL1	11.4
Skin	CJM	10.2
Skin	COLO679	11.8
Skin	COLO741	10.9
Skin	COLO783	10.9
Skin	COLO792	10.6
Skin	COLO800	11.3
Skin	COLO818	11.6
Skin	COLO829	10.3
Skin	COLO849	11.1
Skin	G361	10.9
Skin	GRM	10.9
Skin	HMCB	11.8
Skin	HS294T	11
Skin	HS600T	11
Skin	HS688AT	10.5
Skin	HS695T	10.9
Skin	HS839T	10.9
Skin	HS852T	11.4
Skin	HS895T	11
Skin	HS934T	10.9
Skin	HS936T	11.2
Skin	HS939T	11.5
Skin	HS940T	10.4
Skin	HS944T	11.3
Skin	HT144	11.4
Skin	IGR1	11.2
Skin	IGR37	11.6
Skin	IGR39	11.5
Skin	IPC298	11.3
Skin	K029AX	11.1
Skin	LOXIMVI	11.6
Skin	MALME3M	11.1
Skin	MDAMB435S	11.9
Skin	MELHO	10.9
Skin	MELJUSO	11.4
Skin	MEWO	11.2
Skin	RPMI7951	11.7
Skin	RVH421	11.2
Skin	SH4	11.4
Skin	SKMEL1	11.7
Skin	SKMEL24	11
Skin	SKMEL28	11.5
Skin	SKMEL2	11.2
Skin	SKMEL30	11.7
Skin	SKMEL31	10.9
Skin	SKMEL3	11.5
Skin	SKMEL5	11
Skin	UACC257	11.4
Skin	UACC62	11.2
Skin	WM115	10.9
Skin	WM1799	3.5
Skin	WM2664	11.4
Skin	WM793	11.6
Skin	WM88	11.1
Skin	WM983B	11.7
Small intestine	HUTU80	11.3
Soft tissue	A204	11.4
Soft tissue	G401	11.8
Soft tissue	G402	11.4
Soft tissue	GCT	11.5
Soft tissue	HS729	10.9
Soft tissue	HT1080	11.3
Soft tissue	KYM1	11.6
Soft tissue	MESSA	10.5
Soft tissue	RD	12.2
Soft tissue	RH30	11
Soft tissue	RH41	11.1
Soft tissue	RKN	11.5
Soft tissue	S117	10.8
Soft tissue	SJRH30	11.2
Soft tissue	SKLMS1	10.9
Soft tissue	SKUT1	11.6
Soft tissue	TE125T	11.5
Soft tissue	TE159T	10.6
Soft tissue	TE441T	11.5
Soft tissue	TE617T	11.6
Stomach	2313287	10.5
Stomach	AGS	11.3
Stomach	AZ521	11.4
Stomach	ECC10	11
Stomach	ECC12	11.2
Stomach	FU97	10.5
Stomach	GCIY	10.1
Stomach	GSS	11.5
Stomach	GSU	10.4
Stomach	HGC27	11.7
Stomach	HS746T	11.6
Stomach	HUG1N	11.6
Stomach	IM95	11.2
Stomach	KATOIII	11.5
Stomach	KE39	11.8
Stomach	LMSU	11.5
Stomach	MKN1	11.4
Stomach	MKN45	11.7
Stomach	MKN74	11.5
Stomach	MKN7	11.4
Stomach	NCCSTCK140	10.5
Stomach	NCIN87	11.6
Stomach	NUGC2	11.9
Stomach	NUGC3	11.8
Stomach	NUGC4	10.6
Stomach	OCUM1	10.5
Stomach	RERFGC1B	11.1
Stomach	SH10TC	10.7
Stomach	SNU16	10.9
Stomach	SNU1	11.7
Stomach	SNU216	10.7
Stomach	SNU520	11.1
Stomach	SNU5	11.3
Stomach	SNU601	11.5
Stomach	SNU620	10.6
Stomach	SNU668	10.8
Stomach	SNU719	10.3
Stomach	TGBC11TKB	10.3
Thyroid	8305C	11
Thyroid	8505C	11.2
Thyroid	BCPAP	9.6
Thyroid	BHT101	10.3
Thyroid	CAL62	11.2
Thyroid	CGTHW1	10.7
Thyroid	FTC133	10.7
Thyroid	FTC238	11.2
Thyroid	ML1	10.5
Thyroid	SW579	11.2
Thyroid	TT2609C02	11.2
Thyroid	TT	10.3
Upper aerodigestive tract	BHY	10.1
Upper aerodigestive tract	BICR16	10.9
Upper aerodigestive tract	BICR18	12.1
Upper aerodigestive tract	BICR22	10
Upper aerodigestive tract	BICR31	10.7
Upper aerodigestive tract	BICR56	9.7
Upper aerodigestive tract	BICR6	10.4
Upper aerodigestive tract	CAL27	11
Upper aerodigestive tract	CAL33	11.1
Upper aerodigestive tract	DETROIT562	11.6
Upper aerodigestive tract	FADU	11.5
Upper aerodigestive tract	HS840T	11
Upper aerodigestive tract	HSC2	10.8
Upper aerodigestive tract	HSC3	11.8
Upper aerodigestive tract	HSC4	10.8
Upper aerodigestive tract	PECAPJ15	11
Upper aerodigestive tract	PECAPJ34CLONEC12	11
Upper aerodigestive tract	PECAPJ41CLONED2	10.8
Upper aerodigestive tract	PECAPJ49	11.3
Upper aerodigestive tract	SCC15	10.7
Upper aerodigestive tract	SCC25	11.1
Upper aerodigestive tract	SCC4	11
Upper aerodigestive tract	SCC9	10.3
Upper aerodigestive tract	SNU1076	9.9
Upper aerodigestive tract	SNU1214	11.3
Upper aerodigestive tract	SNU46	11.3
Upper aerodigestive tract	SNU899	10.7
Upper aerodigestive tract	YD10B	11.1
Upper aerodigestive tract	YD38	11.1
Upper aerodigestive tract	YD8	10.9
Urinary tract	5637	11.1
Urinary tract	639V	11.4
Urinary tract	647V	11.2
Urinary tract	BC3C	11.7
Urinary tract	BFTC905	10.7
Urinary tract	CAL29	11.4
Urinary tract	HS172T	11
Urinary tract	HT1197	11
Urinary tract	HT1376	11.4
Urinary tract	J82	11.5
Urinary tract	JMSU1	10.9
Urinary tract	KMBC2	11.1
Urinary tract	KU1919	11.3
Urinary tract	RT11284	11.5
Urinary tract	RT112	11.4
Urinary tract	RT4	11.8
Urinary tract	SCABER	11.4
Urinary tract	SW1710	10.7
Urinary tract	SW780	11.1
Urinary tract	T24	11.3
Urinary tract	TCCSUP	10.6
Urinary tract	UMUC1	10.6
Urinary tract	UMUC3	11.6
Urinary tract	VMCUB1	10.5

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	31.6
Adrenal gland	35.8
Appendix	47.1
Bone marrow	37.2
Breast	51
Cerebral cortex	25.2
Cervix, uterine	40.6
Colon	27.9
Duodenum	20.6
Endometrium	40.6
Epididymis	20
Esophagus	29.5
Fallopian tube	39.2
Gallbladder	38.4
Heart muscle	21
Kidney	33.7
Liver	15.4
Lung	38.4
Lymph node	57
Ovary	28.4
Pancreas	6.3
Parathyroid gland	55
Placenta	43.7
Prostate	46.9
Rectum	34.5
Salivary gland	14
Seminal vesicle	33.1
Skeletal muscle	17.6
Skin	27.9
Small intestine	24.6
Smooth muscle	42
Spleen	38.6
Stomach	21.8
Testis	36.8
Thyroid gland	55.1
Tonsil	45.1
Urinary bladder	36.7

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27793800	Underexpression	Chronic Obstructive Pulmonary Disease; Lung Carcinoma	Our qPCR validation data revealed a significant downregulation of Dnmt1, Dnmt3a, Dnmt3b, Hdac2, Hdac4, Hat1, Prmt1, and Aurkb. We identified targeted chromatin histone marks (H3K56ac and H4K12ac), which are induced by CS.
27655674	altered expression	Renal Cell Carcinoma	The results revealed aberrant expression of epigenetic regulatory genes involved in DNA methylation (DNMT1, DNMT3a and MBD4) and histone modifications (HDAC1, HMT1 and HAT1) in HK-2 cells malignantly transformed by chronic oxidative stress.
17182829	Overexpression	Hepatocellular Carcinoma	The expression of Suv4-20h2 and RIZ1 histone methyltransferases (HMTs) steadily decreased along with the development of liver tumors and reached its lowest level in tumor tissue, whereas the expression of Suv39-h1 HMT and histone acetyltransferase 1 (HAT1) substantially increased in tumors.
25120766	Overexpression	Esophageal Squamous Cell Carcinoma	The expression of HAT1 was validated to be higher in the primary tumors and adjacent tissue as compared to that of the normal esophageal tissue.
25358520	Underexpression	Breast Carcinoma	The expression of DNMT3A/B increased at the initial stages of oncogenesis and the expression of DNMT1 and HAT1 decreased at the advanced stages of breast cancer.

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.452	1.04e-21	25.7	60.9	13.4	Neutral
BRCA	Breast invasive carcinoma	1075	0.414	1.16e-45	21.8	68.7	9.5	Neutral
CESC	Cervical and endocervical cancers	292	0.495	1.91e-19	14	72.6	13.4	Neutral
COAD	Colon adenocarcinoma	449	0.181	0.000119	3.3	78.4	18.3	Neutral
ESCA	Esophageal carcinoma	183	0.598	4.16e-19	10.9	56.8	32.2	Neutral
GBM	Glioblastoma multiforme	147	0.331	4.17e-05	6.1	87.1	6.8	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.475	2.54e-30	9.9	70.4	19.6	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.335	3.31e-15	2.7	81.5	15.8	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.29	5.3e-07	1.4	80.6	18.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.074	0.341	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.221	4.36e-07	4.7	93	2.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.43	8.27e-18	12.1	74.2	13.7	Neutral
LUAD	Lung adenocarcinoma	512	0.417	6.24e-23	5.9	64.6	29.5	Neutral
LUSC	Lung squamous cell carcinoma	498	0.549	1.58e-40	9	59.6	31.3	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.567	7.13e-27	9.7	49	41.3	Gain
PAAD	Pancreatic adenocarcinoma	177	0.438	1.06e-09	3.4	84.2	12.4	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.292	0.000165	8	90.7	1.2	Neutral
PRAD	Prostate adenocarcinoma	491	0.415	7.49e-22	11.6	86.6	1.8	Neutral
READ	Rectum adenocarcinoma	164	0.304	7.41e-05	6.1	68.3	25.6	Neutral
SARC	Sarcoma	255	0.411	7.99e-12	29	59.6	11.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.417	6.88e-17	15	65.4	19.6	Neutral
STAD	Stomach adenocarcinoma	413	0.362	2.92e-14	10.2	72.4	17.4	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.231	0.00453	4	65.3	30.7	Neutral
THCA	Thyroid carcinoma	497	0.138	0.00198	2	97.8	0.2	Neutral
THYM	Thymoma	119	0.239	0.00898	2.5	97.5	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.164	0.000141	3.7	78.8	17.5	Neutral

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.159	0.00104	17	408	-0.002	0.905	NS/NA
BRCA	Breast invasive carcinoma	-0.205	1.13e-09	83	785	0.001	1.93e-05	NS/NA
CESC	Cervical and endocervical cancers	-0.273	1.25e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.044	0.434	19	297	0	0.714	NS/NA
ESCA	Esophageal carcinoma	-0.214	0.00284	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.225	0.0712	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.152	0.000382	20	522	-0.026	0.000508	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.144	0.00747	24	319	0.006	0.00496	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.141	0.015	23	275	0.004	0.000149	NS/NA
LAML	Acute Myeloid Leukemia	-0.189	0.0136	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.108	0.0128	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.198	5.3e-05	41	373	0.002	0.000402	NS/NA
LUAD	Lung adenocarcinoma	-0.158	0.000517	21	456	-0.006	6.41e-06	NS/NA
LUSC	Lung squamous cell carcinoma	-0.21	3.94e-05	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.683	0.0503	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.228	0.00192	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.119	0.105	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.189	1.13e-05	35	498	-0.002	0.524	NS/NA
READ	Rectum adenocarcinoma	-0.23	0.0207	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.174	0.00474	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.189	3.79e-05	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.174	0.000772	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.544	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.095	0.0241	50	509	-0.001	0.0673	NS/NA
THYM	Thymoma	-0.063	0.49	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.189	4.13e-05	34	431	-0.016	0.172	NS/NA

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	2	Medium
Appendix	3	High
Bone marrow	3	High
Breast	2	Medium
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	2	Medium
Liver	0	Not detected
Lung	0	Not detected
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	2	Medium
Ovary	1	Low
Pancreas	1	Low
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	2	Medium
Skeletal muscle	1	Low
Skin	3	High
Small intestine	3	High
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	3	High
Testis	3	High
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.112	NS	24476821
BRCA	Breast invasive carcinoma	521	6.75e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0469	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00338	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.0186	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.141	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.62e-17	Significant	26824661
LUAD	Lung adenocarcinoma	230	4.54e-09	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	8.43e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	5.34e-05	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0339	Significant	26544944
READ	Rectum adenocarcinoma	67	0.537	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.468	NS	26091043
STAD	Stomach adenocarcinoma	277	2.78e-13	Significant	25079317
THCA	Thyroid carcinoma	391	2.55e-07	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0157	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.652	0.0258	Shorter
BRCA	Breast invasive carcinoma	1079	1.106	0.651	NS
CESC	Cervical and endocervical cancers	291	0.854	0.656	NS
COAD	Colon adenocarcinoma	439	0.623	0.0928	NS
ESCA	Esophageal carcinoma	184	1.254	0.515	NS
GBM	Glioblastoma multiforme	158	1.099	0.721	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.228	0.283	NS
KIRC	Kidney renal clear cell carcinoma	531	0.653	0.0338	Longer
KIRP	Kidney renal papillary cell carcinoma	287	1.299	0.499	NS
LAML	Acute Myeloid Leukemia	149	1.586	0.128	NS
LGG	Brain Lower Grade Glioma	511	3.855	3.57e-07	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.728	0.0237	Shorter
LUAD	Lung adenocarcinoma	502	1.717	0.00941	Shorter
LUSC	Lung squamous cell carcinoma	494	0.798	0.247	NS
OV	Ovarian serous cystadenocarcinoma	303	0.807	0.298	NS
PAAD	Pancreatic adenocarcinoma	177	1.775	0.0577	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.624	0.597	NS
PRAD	Prostate adenocarcinoma	497	0.814	0.787	NS
READ	Rectum adenocarcinoma	159	0.863	0.808	NS
SARC	Sarcoma	259	0.989	0.968	NS
SKCM	Skin Cutaneous Melanoma	459	0.721	0.0883	NS
STAD	Stomach adenocarcinoma	388	0.584	0.0216	Longer
TGCT	Testicular Germ Cell Tumors	134	0	0.309	NS
THCA	Thyroid carcinoma	500	0.314	0.134	NS
THYM	Thymoma	119	0.289	0.351	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	2.235	0.00895	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.004	0.935	NS
BRCA	Breast invasive carcinoma	1071	-0.051	0.0939	NS
CESC	Cervical and endocervical cancers	167	-0.088	0.259	NS
COAD	Colon adenocarcinoma	445	-0.111	0.0186	Lower
ESCA	Esophageal carcinoma	162	0.026	0.747	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.035	0.465	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.017	0.692	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.066	0.291	NS
LIHC	Liver hepatocellular carcinoma	347	0.111	0.0385	Higher
LUAD	Lung adenocarcinoma	507	0.115	0.0097	Higher
LUSC	Lung squamous cell carcinoma	497	0.032	0.471	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.089	0.121	NS
PAAD	Pancreatic adenocarcinoma	176	0.057	0.451	NS
READ	Rectum adenocarcinoma	156	-0.061	0.452	NS
SKCM	Skin Cutaneous Melanoma	410	-0.033	0.502	NS
STAD	Stomach adenocarcinoma	392	-0.056	0.269	NS
TGCT	Testicular Germ Cell Tumors	81	-0.067	0.552	NS
THCA	Thyroid carcinoma	499	-0.021	0.643	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.138	0.00194	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.055	0.366	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.113	0.0114	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.038	0.381	NS
LGG	Brain Lower Grade Glioma	514	0.17	0.000104	Higher
LIHC	Liver hepatocellular carcinoma	366	0.118	0.0244	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.012	0.837	NS
PAAD	Pancreatic adenocarcinoma	176	0.097	0.2	NS
STAD	Stomach adenocarcinoma	406	-0.053	0.291	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.382	4.96e-20	Higher

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for HAT1.

Summary
Symbol	HAT1
Name	histone acetyltransferase 1
Aliases	Histone acetyltransferase type B catalytic subunit
Location	2q31.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for HAT1.