CR2Cancer

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF01344 Kelch motif

Function

Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	#	#	12670868

> Gene Ontology [ TOP ]
Biological Process	GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019042 viral latency GO:0019046 release from viral latency GO:0031647 regulation of protein stability GO:0043254 regulation of protein complex assembly GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043981 histone H4-K5 acetylation GO:0043982 histone H4-K8 acetylation GO:0043984 histone H4-K16 acetylation GO:0045787 positive regulation of cell cycle GO:0050821 protein stabilization GO:0071407 cellular response to organic cyclic compound
Molecular Function	GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0010485 H4 histone acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0034212 peptide N-acetyltransferase activity GO:0043995 histone acetyltransferase activity (H4-K5 specific) GO:0043996 histone acetyltransferase activity (H4-K8 specific) GO:0045296 cadherin binding GO:0046972 histone acetyltransferase activity (H4-K16 specific) GO:0050839 cell adhesion molecule binding GO:0061733 peptide-lysine-N-acetyltransferase activity GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex GO:0005913 cell-cell adherens junction GO:0030424 axon GO:0030425 dendrite GO:0031248 protein acetyltransferase complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0043025 neuronal cell body GO:0044297 cell body GO:0044665 MLL1/2 complex GO:0048188 Set1C/COMPASS complex GO:0070461 SAGA-type complex GO:0070688 MLL5-L complex GO:0071339 MLL1 complex GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-5688426: Deubiquitination R-HSA-3214847: HATs acetylate histones R-HSA-392499: Metabolism of proteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-597592: Post-translational protein modification R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis R-HSA-5689603: UCH proteinases

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-5688426: Deubiquitination
R-HSA-3214847: HATs acetylate histones
R-HSA-392499: Metabolism of proteins
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-597592: Post-translational protein modification
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-5689603: UCH proteinases

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1117721	c.4107C>T	p.I1369I	Substitution - coding silent	Endometrium
COSM4107979	c.3036C>T	p.C1012C	Substitution - coding silent	Stomach
COSM71025	c.2148A>T	p.K716N	Substitution - Missense	Ovary
COSM1117749	c.2532A>G	p.A844A	Substitution - coding silent	Endometrium
COSM4137768	c.3584C>A	p.P1195Q	Substitution - Missense	Ovary
COSM4893315	c.2297C>T	p.S766F	Substitution - Missense	Skin
COSM161460	c.1578C>T	p.S526S	Substitution - coding silent	Breast
COSM1209346	c.1597C>T	p.R533C	Substitution - Missense	Large_intestine
COSM1466710	c.113G>A	p.R38Q	Substitution - Missense	Large_intestine
COSM5463847	c.1345G>A	p.A449T	Substitution - Missense	Large_intestine
COSM3559632	c.2300C>T	p.A767V	Substitution - Missense	Skin
COSM457084	c.1273C>T	p.R425W	Substitution - Missense	Breast
COSM4499808	c.5218C>T	p.P1740S	Substitution - Missense	Upper_aerodigestive_tract
COSM5724482	c.5666G>A	p.R1889H	Substitution - Missense	Skin
COSM5345955	c.3479T>A	p.V1160E	Substitution - Missense	Large_intestine
COSM1173574	c.734G>A	p.R245H	Substitution - Missense	Oesophagus
COSM1117747	c.2693C>T	p.T898I	Substitution - Missense	Endometrium
COSM4966313	c.419C>T	p.T140I	Substitution - Missense	Prostate
COSM3559648	c.949C>A	p.P317T	Substitution - Missense	Skin
COSM3844036	c.3064A>C	p.T1022P	Substitution - Missense	Breast
COSM1117755	c.1763C>T	p.S588L	Substitution - Missense	Skin
COSM5802725	c.415+7A>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM302349	c.660C>T	p.P220P	Substitution - coding silent	Skin
COSM1490667	c.1666G>C	p.V556L	Substitution - Missense	Breast
COSM4107963	c.3920G>A	p.G1307D	Substitution - Missense	Stomach
COSM4479122	c.2007C>T	p.T669T	Substitution - coding silent	Skin
COSM4107969	c.3669G>A	p.P1223P	Substitution - coding silent	Stomach
COSM5968139	c.2185G>T	p.G729W	Substitution - Missense	Genital_tract
COSM5910007	c.2061G>A	p.T687T	Substitution - coding silent	Skin
COSM4391607	c.3178G>C	p.E1060Q	Substitution - Missense	Breast
COSM1683028	c.5665C>T	p.R1889C	Substitution - Missense	Large_intestine
COSM3694435	c.5481C>T	p.S1827S	Substitution - coding silent	Large_intestine
COSM1253991	c.3622G>A	p.A1208T	Substitution - Missense	Oesophagus
COSM755715	c.2986A>T	p.T996S	Substitution - Missense	Lung
COSM3236592	c.1392G>A	p.S464S	Substitution - coding silent	Cervix
COSM1625697	c.652A>G	p.N218D	Substitution - Missense	Liver
COSM5412318	c.1153C>T	p.P385S	Substitution - Missense	Skin
COSM4495753	c.4311C>T	p.V1437V	Substitution - coding silent	Skin
COSM4107999	c.217G>T	p.D73Y	Substitution - Missense	Stomach
COSM1315345	c.103C>G	p.P35A	Substitution - Missense	Urinary_tract
COSM5698655	c.1596C>A	p.T532T	Substitution - coding silent	Soft_tissue
COSM3694437	c.4898G>A	p.S1633N	Substitution - Missense	Large_intestine
COSM4629001	c.865G>T	p.A289S	Substitution - Missense	Large_intestine
COSM4540185	c.2509G>A	p.A837T	Substitution - Missense	Skin
COSM457080	c.2792C>A	p.T931K	Substitution - Missense	Breast
COSM4107985	c.1131C>T	p.T377T	Substitution - coding silent	Stomach
COSM5623046	c.5768C>G	p.S1923C	Substitution - Missense	Oesophagus
COSM128137	c.1491C>T	p.A497A	Substitution - coding silent	Upper_aerodigestive_tract
COSM206618	c.5268G>A	p.K1756K	Substitution - coding silent	Soft_tissue
COSM5956035	c.2846T>C	p.V949A	Substitution - Missense	Upper_aerodigestive_tract
COSM5938509	c.3745G>A	p.E1249K	Substitution - Missense	Skin
COSM488146	c.1852C>T	p.P618S	Substitution - Missense	Kidney
COSM4107957	c.4571C>A	p.A1524D	Substitution - Missense	Stomach
COSM5472849	c.4944G>A	p.A1648A	Substitution - coding silent	Large_intestine
COSM3236588	c.1520A>G	p.N507S	Substitution - Missense	Large_intestine
COSM4107981	c.2662C>A	p.P888T	Substitution - Missense	Stomach
COSM2152399	c.117C>A	p.L39L	Substitution - coding silent	Central_nervous_system
COSM3913641	c.4920C>T	p.A1640A	Substitution - coding silent	Skin
COSM4955050	c.3618C>A	p.N1206K	Substitution - Missense	Liver
COSM1117765	c.688G>A	p.A230T	Substitution - Missense	Endometrium
COSM4955050	c.3618C>A	p.N1206K	Substitution - Missense	Liver
COSM4748008	c.2267delG	p.G756fs*22	Deletion - Frameshift	Stomach
COSM1625693	c.3195T>A	p.S1065S	Substitution - coding silent	Liver
COSM4957813	c.5341A>T	p.S1781C	Substitution - Missense	Liver
COSM4137768	c.3584C>A	p.P1195Q	Substitution - Missense	Ovary
COSM3236469	c.4418T>C	p.V1473A	Substitution - Missense	Large_intestine
COSM5642959	c.2653C>G	p.L885V	Substitution - Missense	Oesophagus
COSM4762858	c.2033C>T	p.S678L	Substitution - Missense	Stomach
COSM4940686	c.3525G>A	p.V1175V	Substitution - coding silent	Liver
COSM4689586	c.3600C>T	p.H1200H	Substitution - coding silent	Large_intestine
COSM3236479	c.4229C>T	p.S1410L	Substitution - Missense	Large_intestine
COSM3559620	c.4167C>T	p.T1389T	Substitution - coding silent	Skin
COSM1625691	c.4705G>T	p.E1569*	Substitution - Nonsense	Liver
COSM1466708	c.301delC	p.R101fs*20	Deletion - Frameshift	Large_intestine
COSM3236602	c.700C>T	p.R234C	Substitution - Missense	Small_intestine
COSM3953145	c.2480T>C	p.I827T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM380731	c.2609G>A	p.S870N	Substitution - Missense	Lung
COSM611859	c.425C>T	p.T142M	Substitution - Missense	Stomach
COSM3559644	c.1382C>T	p.P461L	Substitution - Missense	Skin
COSM1117711	c.4657G>A	p.G1553S	Substitution - Missense	Endometrium
COSM161459	c.4153C>T	p.R1385W	Substitution - Missense	Breast
COSM5485198	c.3894G>A	p.A1298A	Substitution - coding silent	Large_intestine
COSM5467850	c.5339T>C	p.F1780S	Substitution - Missense	Large_intestine
COSM294443	c.2943G>A	p.P981P	Substitution - coding silent	Large_intestine
COSM240078	c.406C>A	p.L136I	Substitution - Missense	Prostate
COSM4499808	c.5218C>T	p.P1740S	Substitution - Missense	Skin
COSM4884534	c.2181C>A	p.G727G	Substitution - coding silent	Upper_aerodigestive_tract
COSM1117741	c.2926C>T	p.R976*	Substitution - Nonsense	Endometrium
COSM5665481	c.3699C>A	p.T1233T	Substitution - coding silent	Soft_tissue
COSM1117745	c.2708G>A	p.G903D	Substitution - Missense	Endometrium
COSM5576701	c.1844C>T	p.T615I	Substitution - Missense	Skin
COSM4635790	c.2395G>A	p.G799R	Substitution - Missense	Large_intestine
COSM4689600	c.281A>G	p.Y94C	Substitution - Missense	Large_intestine
COSM5031287	c.1589C>T	p.T530M	Substitution - Missense	Pancreas
COSM4689598	c.445A>G	p.S149G	Substitution - Missense	Large_intestine
COSM1117755	c.1763C>T	p.S588L	Substitution - Missense	Skin
COSM5904506	c.2423C>T	p.S808F	Substitution - Missense	Skin
COSM457084	c.1273C>T	p.R425W	Substitution - Missense	Oesophagus
COSM404207	c.3735G>T	p.T1245T	Substitution - coding silent	Lung
COSM1132364	c.1356T>G	p.A452A	Substitution - coding silent	Prostate
COSM3559640	c.1742C>T	p.S581F	Substitution - Missense	Skin
COSM4107977	c.3051G>A	p.T1017T	Substitution - coding silent	Stomach
COSM3973450	c.950C>G	p.P317R	Substitution - Missense	Central_nervous_system
COSM5620930	c.3820G>A	p.V1274I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1117705	c.5190C>A	p.H1730Q	Substitution - Missense	Endometrium
COSM3236544	c.2692A>G	p.T898A	Substitution - Missense	Lung
COSM5698657	c.996A>G	p.A332A	Substitution - coding silent	Soft_tissue
COSM161458	c.3745G>C	p.E1249Q	Substitution - Missense	Breast
COSM5724482	c.5666G>A	p.R1889H	Substitution - Missense	Skin
COSM1466696	c.2447delT	p.L816fs*11	Deletion - Frameshift	Large_intestine
COSM4651709	c.1354G>A	p.A452T	Substitution - Missense	Large_intestine
COSM5366881	c.4870G>A	p.D1624N	Substitution - Missense	Large_intestine
COSM4107967	c.3675C>T	p.C1225C	Substitution - coding silent	Stomach
COSM4107989	c.644T>C	p.L215P	Substitution - Missense	Stomach
COSM1117697	c.5658C>T	p.I1886I	Substitution - coding silent	Endometrium
COSM4807405	c.4810C>A	p.Q1604K	Substitution - Missense	Pancreas
COSM5475330	c.2854G>A	p.V952I	Substitution - Missense	Large_intestine
COSM5064532	c.2248C>T	p.R750C	Substitution - Missense	Skin
COSM3559624	c.4142C>T	p.S1381F	Substitution - Missense	Skin
COSM5964910	c.225T>C	p.Y75Y	Substitution - coding silent	Breast
COSM1117737	c.2949C>T	p.C983C	Substitution - coding silent	Endometrium
COSM4773920	c.3128C>A	p.A1043E	Substitution - Missense	Stomach
COSM4589297	c.1542G>A	p.K514K	Substitution - coding silent	Bone
COSM3559630	c.2648C>T	p.S883F	Substitution - Missense	Skin
COSM5757501	c.449G>T	p.G150V	Substitution - Missense	Large_intestine
COSM3236630	c.83C>T	p.T28M	Substitution - Missense	Stomach
COSM457076	c.5568C>T	p.C1856C	Substitution - coding silent	Large_intestine
COSM5064532	c.2248C>T	p.R750C	Substitution - Missense	Skin
COSM3844040	c.2008A>C	p.T670P	Substitution - Missense	Breast
COSM3694207	c.2432C>T	p.T811M	Substitution - Missense	Large_intestine
COSM161460	c.1578C>T	p.S526S	Substitution - coding silent	Breast
COSM5782528	c.4031G>T	p.S1344I	Substitution - Missense	Breast
COSM1625695	c.1745A>G	p.N582S	Substitution - Missense	Liver
COSM4797467	c.2055C>A	p.G685G	Substitution - coding silent	Liver
COSM4107983	c.1552G>A	p.A518T	Substitution - Missense	Stomach
COSM4107953	c.5689G>A	p.A1897T	Substitution - Missense	Stomach
COSM4156731	c.3621C>A	p.T1207T	Substitution - coding silent	Thyroid
COSM74870	c.1933A>G	p.S645G	Substitution - Missense	Ovary
COSM457078	c.4190C>T	p.P1397L	Substitution - Missense	Breast
COSM5686296	c.2559C>T	p.T853T	Substitution - coding silent	Soft_tissue
COSM1117707	c.5069G>A	p.G1690D	Substitution - Missense	Endometrium
COSM1117753	c.2060C>T	p.T687M	Substitution - Missense	Endometrium
COSM311708	c.1520A>C	p.N507T	Substitution - Missense	Lung
COSM3844030	c.4594G>A	p.E1532K	Substitution - Missense	Breast
COSM1466684	c.5659G>A	p.A1887T	Substitution - Missense	Large_intestine
COSM4550816	c.4812G>A	p.Q1604Q	Substitution - coding silent	Skin
COSM4393089	c.1974C>T	p.S658S	Substitution - coding silent	Prostate
COSM1117717	c.4539G>T	p.E1513D	Substitution - Missense	Endometrium
COSM5959686	c.4699C>G	p.Q1567E	Substitution - Missense	Thyroid
COSM1165521	c.408A>C	p.L136L	Substitution - coding silent	Large_intestine
COSM1117769	c.456G>A	p.A152A	Substitution - coding silent	Endometrium
COSM1315339	c.1822C>G	p.P608A	Substitution - Missense	Urinary_tract
COSM2152399	c.117C>A	p.L39L	Substitution - coding silent	Central_nervous_system
COSM382737	c.1353C>T	p.A451A	Substitution - coding silent	Large_intestine
COSM5947762	c.5393G>T	p.C1798F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1497228	c.1819G>C	p.G607R	Substitution - Missense	Kidney
COSM1117727	c.3632C>T	p.S1211L	Substitution - Missense	Endometrium
COSM4689592	c.2376C>T	p.T792T	Substitution - coding silent	Large_intestine
COSM3236608	c.506A>G	p.Y169C	Substitution - Missense	Large_intestine
COSM4966549	c.1958T>C	p.I653T	Substitution - Missense	Prostate
COSM5619141	c.4251G>T	p.L1417L	Substitution - coding silent	Breast
COSM4107959	c.4449C>T	p.S1483S	Substitution - coding silent	Stomach
COSM4957813	c.5341A>T	p.S1781C	Substitution - Missense	Liver
COSM1490665	c.4063G>A	p.D1355N	Substitution - Missense	Breast
COSM1292961	c.3578C>A	p.S1193Y	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1117713	c.4622T>C	p.V1541A	Substitution - Missense	Endometrium
COSM1569622	c.4400C>T	p.S1467F	Substitution - Missense	Large_intestine
COSM4689582	c.3764delC	p.P1255fs*40	Deletion - Frameshift	Large_intestine
COSM3424626	c.2314G>A	p.V772I	Substitution - Missense	Large_intestine
COSM1117751	c.2353A>G	p.T785A	Substitution - Missense	Endometrium
COSM5770636	c.2854G>T	p.V952F	Substitution - Missense	Breast
COSM1625693	c.3195T>A	p.S1065S	Substitution - coding silent	Liver
COSM1733420	c.4676C>T	p.S1559F	Substitution - Missense	Pancreas
COSM1117735	c.3046G>A	p.E1016K	Substitution - Missense	Endometrium
COSM1315343	c.1164C>T	p.L388L	Substitution - coding silent	Urinary_tract
COSM3844034	c.3136A>C	p.T1046P	Substitution - Missense	Breast
COSM5064532	c.2248C>T	p.R750C	Substitution - Missense	Stomach
COSM1466694	c.2531C>T	p.A844V	Substitution - Missense	Large_intestine
COSM5653191	c.3482G>C	p.C1161S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM255708	c.768C>A	p.D256E	Substitution - Missense	Central_nervous_system
COSM388655	c.669G>T	p.R223R	Substitution - coding silent	Lung
COSM5591229	c.202C>T	p.P68S	Substitution - Missense	Skin
COSM5587962	c.2823G>A	p.G941G	Substitution - coding silent	Skin
COSM5587960	c.3286C>T	p.L1096F	Substitution - Missense	Skin
COSM1195919	c.5196C>A	p.F1732L	Substitution - Missense	Lung
COSM3390512	c.1607T>C	p.I536T	Substitution - Missense	Pancreas
COSM1117729	c.3601G>A	p.E1201K	Substitution - Missense	Endometrium
COSM3559628	c.2959G>A	p.E987K	Substitution - Missense	Skin
COSM1190650	c.116T>C	p.L39P	Substitution - Missense	Lung
COSM1117753	c.2060C>T	p.T687M	Substitution - Missense	Liver
COSM5668634	c.3820G>T	p.V1274F	Substitution - Missense	Soft_tissue
COSM488148	c.260C>G	p.A87G	Substitution - Missense	Kidney
COSM3747384	c.4651+8C>T	p.?	Unknown	Liver
COSM4107961	c.3926C>T	p.A1309V	Substitution - Missense	Stomach
COSM6018835	c.2850G>T	p.Q950H	Substitution - Missense	Skin
COSM4107993	c.383G>A	p.C128Y	Substitution - Missense	Stomach
COSM1117761	c.1070C>T	p.P357L	Substitution - Missense	Endometrium
COSM1117739	c.2942C>T	p.P981L	Substitution - Missense	Large_intestine
COSM5029059	c.2314G>T	p.V772F	Substitution - Missense	Breast
COSM293304	c.105G>A	p.P35P	Substitution - coding silent	Large_intestine
COSM1683028	c.5665C>T	p.R1889C	Substitution - Missense	Large_intestine
COSM1117703	c.5375G>A	p.G1792D	Substitution - Missense	Endometrium
COSM1117723	c.3825C>T	p.S1275S	Substitution - coding silent	Endometrium
COSM4107971	c.3645C>T	p.S1215S	Substitution - coding silent	Stomach
COSM5757501	c.449G>T	p.G150V	Substitution - Missense	Large_intestine
COSM457076	c.5568C>T	p.C1856C	Substitution - coding silent	Thyroid
COSM5412318	c.1153C>T	p.P385S	Substitution - Missense	Skin
COSM6005435	c.4393G>A	p.A1465T	Substitution - Missense	Prostate
COSM3236604	c.634A>G	p.M212V	Substitution - Missense	Large_intestine
COSM1117725	c.3647C>T	p.A1216V	Substitution - Missense	Endometrium
COSM5064530	c.4092C>T	p.G1364G	Substitution - coding silent	Stomach
COSM5498496	c.3226G>A	p.A1076T	Substitution - Missense	Biliary_tract
COSM1285321	c.2439C>T	p.I813I	Substitution - coding silent	Autonomic_ganglia
COSM1117731	c.3426C>T	p.T1142T	Substitution - coding silent	Endometrium
COSM3236568	c.2004G>A	p.T668T	Substitution - coding silent	Stomach
COSM1241242	c.141C>T	p.G47G	Substitution - coding silent	Oesophagus
COSM4638075	c.5751C>T	p.N1917N	Substitution - coding silent	Large_intestine
COSM5595837	c.5609C>T	p.S1870F	Substitution - Missense	Skin
COSM4544616	c.3313G>A	p.G1105R	Substitution - Missense	Skin
COSM457074	c.5774A>G	p.E1925G	Substitution - Missense	Breast
COSM3236439	c.5613C>T	p.N1871N	Substitution - coding silent	Large_intestine
COSM377795	c.4121C>T	p.A1374V	Substitution - Missense	Lung
COSM3708518	c.951G>C	p.P317P	Substitution - coding silent	Liver
COSM5791470	c.3561C>T	p.T1187T	Substitution - coding silent	Breast
COSM1165523	c.302G>A	p.R101Q	Substitution - Missense	Large_intestine
COSM4915765	c.1995G>A	p.K665K	Substitution - coding silent	Liver
COSM1331143	c.1911C>T	p.T637T	Substitution - coding silent	Ovary
COSM4651707	c.3293C>T	p.P1098L	Substitution - Missense	Large_intestine
COSM5345953	c.5291C>T	p.A1764V	Substitution - Missense	Large_intestine
COSM3559618	c.4351G>A	p.D1451N	Substitution - Missense	Skin
COSM4406794	c.2539C>T	p.L847F	Substitution - Missense	Pancreas
COSM457082	c.2218G>T	p.G740W	Substitution - Missense	Breast
COSM1490671	c.917C>A	p.T306K	Substitution - Missense	Breast
COSM3844038	c.2734G>A	p.V912I	Substitution - Missense	Breast
COSM3236572	c.1861G>A	p.A621T	Substitution - Missense	Breast
COSM5711549	c.3665A>C	p.N1222T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4689580	c.3862A>G	p.R1288G	Substitution - Missense	Large_intestine
COSM5546941	c.181_189delGAGGACCCA	p.E61_P63delEDP	Deletion - In frame	Prostate
COSM3694207	c.2432C>T	p.T811M	Substitution - Missense	Stomach
COSM4107987	c.1047G>A	p.L349L	Substitution - coding silent	Stomach
COSM255708	c.768C>A	p.D256E	Substitution - Missense	Central_nervous_system
COSM5835905	c.3972_3973insC	p.C1325fs*2	Insertion - Frameshift	Breast
COSM1117719	c.4396G>A	p.G1466S	Substitution - Missense	Skin
COSM4919511	c.1308G>T	p.T436T	Substitution - coding silent	Liver
COSM3964935	c.3837G>C	p.L1279L	Substitution - coding silent	Lung
COSM1625697	c.652A>G	p.N218D	Substitution - Missense	Liver
COSM5757499	c.3845A>G	p.D1282G	Substitution - Missense	Large_intestine
COSM1117767	c.681C>T	p.C227C	Substitution - coding silent	Endometrium
COSM3559616	c.5396C>T	p.A1799V	Substitution - Missense	Skin
COSM4968114	c.910C>A	p.P304T	Substitution - Missense	Adrenal_gland
COSM3559634	c.2272C>T	p.R758C	Substitution - Missense	Skin
COSM302349	c.660C>T	p.P220P	Substitution - coding silent	Central_nervous_system
COSM3363901	c.5415T>A	p.S1805R	Substitution - Missense	Kidney
COSM1719032	c.2504C>T	p.S835L	Substitution - Missense	Skin
COSM3236546	c.2663C>T	p.P888L	Substitution - Missense	Skin
COSM4107997	c.232G>A	p.E78K	Substitution - Missense	Stomach
COSM4689596	c.967G>A	p.A323T	Substitution - Missense	Large_intestine
COSM4689584	c.3605C>T	p.T1202I	Substitution - Missense	Large_intestine
COSM3559642	c.1496C>T	p.S499L	Substitution - Missense	Skin
COSM4107955	c.5007G>A	p.P1669P	Substitution - coding silent	Stomach
COSM5713019	c.3296G>A	p.S1099N	Substitution - Missense	Central_nervous_system
COSM3844032	c.4305C>T	p.A1435A	Substitution - coding silent	Breast
COSM4689588	c.3562G>A	p.V1188M	Substitution - Missense	Large_intestine
COSM4790145	c.2520G>A	p.T840T	Substitution - coding silent	Liver
COSM3559646	c.1248C>T	p.T416T	Substitution - coding silent	Skin
COSM1117739	c.2942C>T	p.P981L	Substitution - Missense	Endometrium
COSM3372158	c.246C>T	p.G82G	Substitution - coding silent	Thyroid
COSM4107995	c.353A>G	p.K118R	Substitution - Missense	Stomach
COSM1466682	c.5684G>A	p.G1895D	Substitution - Missense	Large_intestine
COSM4797467	c.2055C>A	p.G685G	Substitution - coding silent	Liver
COSM1683028	c.5665C>T	p.R1889C	Substitution - Missense	Large_intestine
COSM5598367	c.2090C>T	p.S697L	Substitution - Missense	Skin
COSM5561640	c.4253C>T	p.P1418L	Substitution - Missense	Prostate
COSM5459494	c.1268G>A	p.G423E	Substitution - Missense	Large_intestine
COSM422188	c.826G>A	p.A276T	Substitution - Missense	Urinary_tract
COSM6018833	c.3118C>G	p.R1040G	Substitution - Missense	Skin
COSM4615389	c.2391_2392insT	p.A798fs*9	Insertion - Frameshift	Large_intestine
COSM4847314	c.733C>T	p.R245C	Substitution - Missense	Cervix
COSM3236556	c.2292C>T	p.T764T	Substitution - coding silent	Soft_tissue
COSM1117769	c.456G>A	p.A152A	Substitution - coding silent	Skin
COSM3414260	c.2398G>T	p.A800S	Substitution - Missense	Oesophagus
COSM1117701	c.5622C>T	p.I1874I	Substitution - coding silent	Endometrium
COSM1117699	c.5626T>C	p.Y1876H	Substitution - Missense	Endometrium
COSM3559626	c.2984C>T	p.T995I	Substitution - Missense	Skin
COSM3236519	c.3766G>T	p.A1256S	Substitution - Missense	Upper_aerodigestive_tract
COSM5884995	c.2441C>T	p.T814I	Substitution - Missense	Breast
COSM1209348	c.587C>T	p.T196M	Substitution - Missense	Large_intestine
COSM363515	c.1907C>A	p.T636N	Substitution - Missense	Lung
COSM3236491	c.4127C>T	p.T1376M	Substitution - Missense	Large_intestine
COSM5724482	c.5666G>A	p.R1889H	Substitution - Missense	Skin
COSM1683028	c.5665C>T	p.R1889C	Substitution - Missense	Large_intestine
COSM4107991	c.532G>A	p.V178I	Substitution - Missense	Stomach
COSM3424622	c.3633G>A	p.S1211S	Substitution - coding silent	Large_intestine
COSM1117773	c.37G>A	p.E13K	Substitution - Missense	Endometrium
COSM1466712	c.96G>C	p.G32G	Substitution - coding silent	Large_intestine
COSM5486788	c.447C>T	p.S149S	Substitution - coding silent	Large_intestine
COSM3559636	c.2099C>T	p.T700I	Substitution - Missense	Skin
COSM4107973	c.3535G>A	p.E1179K	Substitution - Missense	Stomach
COSM5412316	c.4134C>T	p.T1378T	Substitution - coding silent	Skin
COSM4824592	c.5450C>T	p.S1817F	Substitution - Missense	Cervix
COSM3973452	c.254T>G	p.V85G	Substitution - Missense	Central_nervous_system
COSM6018837	c.228C>T	p.I76I	Substitution - coding silent	Skin
COSM4689594	c.1126C>T	p.P376S	Substitution - Missense	Large_intestine
COSM6005437	c.4301C>A	p.S1434Y	Substitution - Missense	Prostate
COSM3424624	c.2853C>A	p.F951L	Substitution - Missense	Large_intestine
COSM1117755	c.1763C>T	p.S588L	Substitution - Missense	Endometrium
COSM5906208	c.3857C>T	p.S1286F	Substitution - Missense	Skin
COSM4156733	c.1025C>T	p.T342I	Substitution - Missense	Thyroid
COSM4689578	c.4619C>T	p.A1540V	Substitution - Missense	Large_intestine
COSM5591231	c.2853C>T	p.F951F	Substitution - coding silent	Skin
COSM5787483	c.1475C>T	p.A492V	Substitution - Missense	Breast
COSM1117743	c.2827C>T	p.H943Y	Substitution - Missense	Endometrium
COSM5645296	c.5500A>G	p.S1834G	Substitution - Missense	Oesophagus
COSM3913643	c.2375C>T	p.T792I	Substitution - Missense	Skin
COSM382737	c.1353C>T	p.A451A	Substitution - coding silent	Lung
COSM5906208	c.3857C>T	p.S1286F	Substitution - Missense	Skin
COSM1466690	c.3927G>A	p.A1309A	Substitution - coding silent	Large_intestine
COSM3708518	c.951G>C	p.P317P	Substitution - coding silent	Liver
COSM1117757	c.1551C>T	p.A517A	Substitution - coding silent	Endometrium
COSM5412314	c.4703C>T	p.A1568V	Substitution - Missense	Skin
COSM5724482	c.5666G>A	p.R1889H	Substitution - Missense	Skin
COSM1209342	c.2428G>A	p.A810T	Substitution - Missense	Large_intestine
COSM6005439	c.824G>A	p.R275H	Substitution - Missense	Prostate
COSM1315341	c.1311G>T	p.V437V	Substitution - coding silent	Urinary_tract
COSM1466702	c.1070delC	p.P357fs*34	Deletion - Frameshift	Large_intestine
COSM5968141	c.283G>T	p.G95W	Substitution - Missense	Genital_tract
COSM5786248	c.1362C>T	p.A454A	Substitution - coding silent	Breast
COSM5977433	c.4002C>T	p.H1334H	Substitution - coding silent	Upper_aerodigestive_tract
COSM4689590	c.2979C>A	p.T993T	Substitution - coding silent	Large_intestine
COSM6005439	c.824G>A	p.R275H	Substitution - Missense	Prostate
COSM1209344	c.823C>T	p.R275C	Substitution - Missense	Large_intestine
COSM1466700	c.1293G>A	p.Q431Q	Substitution - coding silent	Large_intestine
COSM320763	c.5439G>T	p.W1813C	Substitution - Missense	Lung
COSM3939869	c.1862C>T	p.A621V	Substitution - Missense	Oesophagus
COSM364871	c.5058A>T	p.E1686D	Substitution - Missense	Lung
COSM1625695	c.1745A>G	p.N582S	Substitution - Missense	Liver
COSM4404095	c.1121C>T	p.S374F	Substitution - Missense	Skin
COSM1719032	c.2504C>T	p.S835L	Substitution - Missense	Skin
COSM1490669	c.1238C>T	p.A413V	Substitution - Missense	Breast
COSM1117733	c.3415G>T	p.A1139S	Substitution - Missense	Endometrium
COSM1117707	c.5069G>A	p.G1690D	Substitution - Missense	Large_intestine
COSM1117715	c.4554G>A	p.T1518T	Substitution - coding silent	Endometrium
COSM4689576	c.5002delC	p.Q1668fs*17	Deletion - Frameshift	Large_intestine
COSM1117759	c.1147+2T>C	p.?	Unknown	Endometrium
COSM4900180	c.3937C>T	p.P1313S	Substitution - Missense	Skin
COSM4107975	c.3192C>A	p.G1064G	Substitution - coding silent	Stomach
COSM3732447	c.2206-1G>T	p.?	Unknown	Stomach
COSM4107965	c.3893C>T	p.A1298V	Substitution - Missense	Stomach
COSM3559638	c.1922C>T	p.T641I	Substitution - Missense	Skin
COSM1117719	c.4396G>A	p.G1466S	Substitution - Missense	Endometrium
COSM1117771	c.192G>T	p.K64N	Substitution - Missense	Endometrium
COSM3559622	c.4143C>T	p.S1381S	Substitution - coding silent	Skin
COSM3694439	c.4645G>A	p.V1549I	Substitution - Missense	Large_intestine
COSM1117763	c.1052A>G	p.Q351R	Substitution - Missense	Endometrium
COSM488144	c.5763G>A	p.M1921I	Substitution - Missense	Kidney
COSM1466698	c.1532G>A	p.R511H	Substitution - Missense	Large_intestine
COSM1117709	c.4861G>C	p.A1621P	Substitution - Missense	Endometrium
COSM4790145	c.2520G>A	p.T840T	Substitution - coding silent	Liver

> Text Mining based Variations [ TOP ]
There is no record for HCFC1.

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P51610	6	S	Phosphoserine	-	No	None detected
P51610	288	K	N6-acetyllysine	-	No	None detected
P51610	411	S	Phosphoserine	-	No	None detected
P51610	504	R	Omega-N-methylarginine	-	No	None detected
P51610	524	R	Omega-N-methylarginine	-	Yes	p.R524W (cancer: BRCA)
P51610	598	S	Phosphoserine	-	No	None detected
P51610	666	S	Phosphoserine	-	No	None detected
P51610	669	S	Phosphoserine	-	No	None detected
P51610	813	K	N6-acetyllysine	-	Yes	p.K813N (cancer: OV)
P51610	1205	S	Phosphoserine	-	No	None detected
P51610	1219	R	Omega-N-methylarginine	-	No	None detected
P51610	1224	S	Phosphoserine	-	No	None detected
P51610	1491	T	Phosphothreonine	-	No	None detected
P51610	1497	S	Phosphoserine	-	No	None detected
P51610	1507	S	Phosphoserine	-	No	None detected
P51610	1771	S	Phosphoserine	-	No	None detected
P51610	1838	S	Phosphoserine	-	No	None detected
P51610	2005	K	N6-acetyllysine	-	No	None detected

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.677	6.842	0.149	0.195	NS
BRCA	Breast invasive carcinoma	112	1100	6.364	6.798	0.455	1.46e-28	NS
CESC	Cervical and endocervical cancers	3	306	6.876	6.962	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.856	7.101	0.306	0.00126	NS
ESCA	Esophageal carcinoma	11	185	7.648	7.997	0.265	0.15	NS
GBM	Glioblastoma multiforme	5	166	6.969	6.741	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.598	6.79	0.243	0.00384	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.287	6.168	-0.144	0.00979	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.715	6.627	-0.026	0.744	NS
LAML	Acute Myeloid Leukemia	0	173	NA	8.48	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.088	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.031	5.705	0.721	1.02e-23	Over
LUAD	Lung adenocarcinoma	59	517	6.628	6.907	0.307	0.000119	NS
LUSC	Lung squamous cell carcinoma	51	501	6.604	7.037	0.429	1.19e-06	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.729	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.479	6.43	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.637	6.522	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.74	6.811	0.161	0.00839	NS
READ	Rectum adenocarcinoma	10	167	6.638	7.146	0.684	0.00139	Over
SARC	Sarcoma	2	263	6.41	6.85	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.588	7.252	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	7.324	7.784	0.489	1.45e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.631	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.403	6.316	-0.053	0.294	NS
THYM	Thymoma	2	120	7.893	7.352	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.856	6.931	0.127	0.267	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	12.4
Adrenal gland	13.5
Appendix	21.3
Bone marrow	24.7
Breast	7.7
Cerebral cortex	20.1
Cervix, uterine	10.7
Colon	9.9
Duodenum	11.8
Endometrium	19.1
Epididymis	10.2
Esophagus	9.3
Fallopian tube	16
Gallbladder	12.1
Heart muscle	6.2
Kidney	6.3
Liver	2.7
Lung	14.1
Lymph node	22
Ovary	14.5
Pancreas	2.1
Parathyroid gland	22.1
Placenta	12.4
Prostate	15.9
Rectum	7.9
Salivary gland	6.6
Seminal vesicle	18
Skeletal muscle	7.5
Skin	14.7
Small intestine	12.1
Smooth muscle	16.1
Spleen	22.2
Stomach	10
Testis	16.6
Thyroid gland	12.3
Tonsil	11.6
Urinary bladder	10.5

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.251	3.3e-07	18.6	63.6	17.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.126	3.59e-05	16.8	66.1	17	Neutral
CESC	Cervical and endocervical cancers	292	0.203	0.000497	18.2	56.5	25.3	Neutral
COAD	Colon adenocarcinoma	449	0.067	0.155	11.1	69.7	19.2	Neutral
ESCA	Esophageal carcinoma	183	0.136	0.0661	13.7	48.6	37.7	Gain
GBM	Glioblastoma multiforme	147	0.159	0.0547	21.8	70.1	8.2	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.116	0.00869	10.3	61.1	28.6	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.058	0.184	10.7	82.7	6.7	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.055	0.356	9.4	59.4	31.2	Neutral
LAML	Acute Myeloid Leukemia	166	-0.09	0.247	3.6	95.8	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.076	0.0868	15.6	75	9.4	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.014	0.788	17.6	59.1	23.4	Neutral
LUAD	Lung adenocarcinoma	512	0.004	0.934	8	62.1	29.9	Neutral
LUSC	Lung squamous cell carcinoma	498	0.116	0.00988	19.5	56.2	24.3	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.074	0.201	36	26	38	Gain
PAAD	Pancreatic adenocarcinoma	177	0.087	0.25	9	79.1	11.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.043	0.583	32.1	64.2	3.7	Neutral
PRAD	Prostate adenocarcinoma	491	0.09	0.0469	6.7	90.8	2.4	Neutral
READ	Rectum adenocarcinoma	164	0.216	0.00546	14	63.4	22.6	Neutral
SARC	Sarcoma	255	0.205	0.000979	43.5	39.6	16.9	Loss
SKCM	Skin Cutaneous Melanoma	367	0.046	0.378	24.5	59.9	15.5	Neutral
STAD	Stomach adenocarcinoma	413	0.163	0.000853	11.9	69.7	18.4	Neutral
TGCT	Testicular Germ Cell Tumors	150	-0.098	0.234	18.7	64.7	16.7	Neutral
THCA	Thyroid carcinoma	497	0.107	0.0169	0.8	97.4	1.8	Neutral
THYM	Thymoma	119	-0.15	0.104	1.7	89.9	8.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.113	0.00895	12.7	70.2	17.1	Neutral

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.152	0.00168	17	408	-0.01	0.114	NS/NA
BRCA	Breast invasive carcinoma	-0.089	0.00838	83	785	-0.056	4.5e-09	NS/NA
CESC	Cervical and endocervical cancers	-0.115	0.0432	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.061	0.278	19	297	-0.006	0.712	NS/NA
ESCA	Esophageal carcinoma	-0.178	0.0129	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.144	0.253	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.081	0.0589	20	522	0.002	0.807	NS/NA
KIRC	Kidney renal clear cell carcinoma	0.136	0.0119	24	319	0.002	0.042	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.132	0.0223	23	275	-0.003	0.994	NS/NA
LAML	Acute Myeloid Leukemia	-0.171	0.0255	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.089	0.0416	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.059	0.235	41	373	-0.004	0.949	NS/NA
LUAD	Lung adenocarcinoma	-0.122	0.00748	21	456	0.004	0.099	NS/NA
LUSC	Lung squamous cell carcinoma	-0.162	0.00157	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.9	0.00203	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.142	0.0558	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.182	0.0126	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.163	0.000154	35	498	0.002	0.0305	NS/NA
READ	Rectum adenocarcinoma	-0.004	0.967	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.255	3.1e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.065	0.156	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.163	0.00164	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.196	0.0143	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.021	0.62	50	509	-0.04	0.807	NS/NA
THYM	Thymoma	-0.001	0.993	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.089	0.054	34	431	-0.113	1.45e-05	NS/NA

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.212	NS	24476821
BRCA	Breast invasive carcinoma	521	3.11e-14	Significant	23000897
COAD	Colon adenocarcinoma	149	0.00197	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00622	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	5.84e-05	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.178	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.00818	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0236	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00116	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0444	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00218	Significant	26544944
READ	Rectum adenocarcinoma	67	0.248	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.888	NS	26091043
STAD	Stomach adenocarcinoma	277	0.0297	Significant	25079317
THCA	Thyroid carcinoma	391	0.235	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	7.49e-05	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.016	0.937	NS
BRCA	Breast invasive carcinoma	1079	1.724	0.0111	Shorter
CESC	Cervical and endocervical cancers	291	0.831	0.563	NS
COAD	Colon adenocarcinoma	439	1.02	0.944	NS
ESCA	Esophageal carcinoma	184	0.777	0.435	NS
GBM	Glioblastoma multiforme	158	0.835	0.469	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.891	0.551	NS
KIRC	Kidney renal clear cell carcinoma	531	0.816	0.347	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.65	0.268	NS
LAML	Acute Myeloid Leukemia	149	1.233	0.47	NS
LGG	Brain Lower Grade Glioma	511	0.941	0.813	NS
LIHC	Liver hepatocellular carcinoma	365	1.895	0.0102	Shorter
LUAD	Lung adenocarcinoma	502	1.355	0.133	NS
LUSC	Lung squamous cell carcinoma	494	1.3	0.192	NS
OV	Ovarian serous cystadenocarcinoma	303	1.189	0.399	NS
PAAD	Pancreatic adenocarcinoma	177	0.492	0.0191	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	3.37	0.265	NS
PRAD	Prostate adenocarcinoma	497	2.502	0.415	NS
READ	Rectum adenocarcinoma	159	0.633	0.365	NS
SARC	Sarcoma	259	1.242	0.468	NS
SKCM	Skin Cutaneous Melanoma	459	1.902	0.000898	Shorter
STAD	Stomach adenocarcinoma	388	0.592	0.0189	Longer
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	2.65	0.226	NS
THYM	Thymoma	119	0	0.00681	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.62	0.126	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.05	0.317	NS
BRCA	Breast invasive carcinoma	1071	0.054	0.0772	NS
CESC	Cervical and endocervical cancers	167	0.107	0.168	NS
COAD	Colon adenocarcinoma	445	0.018	0.702	NS
ESCA	Esophageal carcinoma	162	-0.069	0.38	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.06	0.204	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.119	0.00598	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.066	0.29	NS
LIHC	Liver hepatocellular carcinoma	347	0.215	5.6e-05	Higher
LUAD	Lung adenocarcinoma	507	0.069	0.12	NS
LUSC	Lung squamous cell carcinoma	497	0.05	0.264	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.174	0.00243	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.146	0.0535	NS
READ	Rectum adenocarcinoma	156	-0.098	0.221	NS
SKCM	Skin Cutaneous Melanoma	410	-0.081	0.101	NS
STAD	Stomach adenocarcinoma	392	-0.025	0.624	NS
TGCT	Testicular Germ Cell Tumors	81	0.079	0.485	NS
THCA	Thyroid carcinoma	499	0.036	0.423	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.012	0.794	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.008	0.896	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.067	0.136	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.016	0.722	NS
LGG	Brain Lower Grade Glioma	514	0.029	0.516	NS
LIHC	Liver hepatocellular carcinoma	366	0.152	0.00362	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.101	0.0838	NS
PAAD	Pancreatic adenocarcinoma	176	0.011	0.883	NS
STAD	Stomach adenocarcinoma	406	-0.036	0.469	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.255	2.23e-09	Higher

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for HCFC1.

Summary
Symbol	HCFC1
Name	host cell factor C1
Aliases	HCF-1; HCF1; CFF; VCAF; MGC70925; PPP1R89; VP16-accessory protein; protein phosphatase 1, regulatory subunit ......
Location	Xq28
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for HCFC1.