CR2Cancer

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00850 Histone deacetylase domain

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone acetylation	H2AKac, H2BKac, H3Kac, H4Kac	H2AK, H2BK, H3K, H4K	9346952

> Gene Ontology [ TOP ]
Biological Process	GO:0000302 response to reactive oxygen species GO:0001101 response to acid chemical GO:0001654 eye development GO:0001819 positive regulation of cytokine production GO:0001837 epithelial to mesenchymal transition GO:0001942 hair follicle development GO:0001975 response to amphetamine GO:0002237 response to molecule of bacterial origin GO:0003012 muscle system process GO:0003300 cardiac muscle hypertrophy GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0006344 maintenance of chromatin silencing GO:0006473 protein acetylation GO:0006476 protein deacetylation GO:0006979 response to oxidative stress GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007423 sensory organ development GO:0007596 blood coagulation GO:0007599 hemostasis GO:0007623 circadian rhythm GO:0008544 epidermis development GO:0009266 response to temperature stimulus GO:0009408 response to heat GO:0009913 epidermal cell differentiation GO:0010001 glial cell differentiation GO:0010035 response to inorganic substance GO:0010712 regulation of collagen metabolic process GO:0010714 positive regulation of collagen metabolic process GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010869 regulation of receptor biosynthetic process GO:0010870 positive regulation of receptor biosynthetic process GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0014074 response to purine-containing compound GO:0014075 response to amine GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0016358 dendrite development GO:0016458 gene silencing GO:0016570 histone modification GO:0016575 histone deacetylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018205 peptidyl-lysine modification GO:0018212 peptidyl-tyrosine modification GO:0018394 peptidyl-lysine acetylation GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0030326 embryonic limb morphogenesis GO:0030534 adult behavior GO:0031000 response to caffeine GO:0031345 negative regulation of cell projection organization GO:0032496 response to lipopolysaccharide GO:0032526 response to retinoic acid GO:0032612 interleukin-1 production GO:0032640 tumor necrosis factor production GO:0032652 regulation of interleukin-1 production GO:0032680 regulation of tumor necrosis factor production GO:0032732 positive regulation of interleukin-1 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032800 receptor biosynthetic process GO:0032922 circadian regulation of gene expression GO:0032963 collagen metabolic process GO:0032964 collagen biosynthetic process GO:0032965 regulation of collagen biosynthetic process GO:0032967 positive regulation of collagen biosynthetic process GO:0034599 cellular response to oxidative stress GO:0034605 cellular response to heat GO:0034614 cellular response to reactive oxygen species GO:0035094 response to nicotine GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035601 protein deacylation GO:0036296 response to increased oxygen levels GO:0040029 regulation of gene expression, epigenetic GO:0042063 gliogenesis GO:0042220 response to cocaine GO:0042303 molting cycle GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0042493 response to drug GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042542 response to hydrogen peroxide GO:0042633 hair cycle GO:0042733 embryonic digit morphogenesis GO:0043010 camera-type eye development GO:0043044 ATP-dependent chromatin remodeling GO:0043112 receptor metabolic process GO:0043279 response to alkaloid GO:0043392 negative regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043543 protein acylation GO:0043586 tongue development GO:0043587 tongue morphogenesis GO:0043588 skin development GO:0044236 multicellular organism metabolic process GO:0044246 regulation of multicellular organismal metabolic process GO:0044253 positive regulation of multicellular organismal metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0044708 single-organism behavior GO:0045342 MHC class II biosynthetic process GO:0045346 regulation of MHC class II biosynthetic process GO:0045347 negative regulation of MHC class II biosynthetic process GO:0045471 response to ethanol GO:0045665 negative regulation of neuron differentiation GO:0045685 regulation of glial cell differentiation GO:0045687 positive regulation of glial cell differentiation GO:0045814 negative regulation of gene expression, epigenetic GO:0045862 positive regulation of proteolysis GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0048149 behavioral response to ethanol GO:0048511 rhythmic process GO:0048709 oligodendrocyte differentiation GO:0048713 regulation of oligodendrocyte differentiation GO:0048714 positive regulation of oligodendrocyte differentiation GO:0048736 appendage development GO:0048762 mesenchymal cell differentiation GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0055093 response to hyperoxia GO:0060173 limb development GO:0060485 mesenchyme development GO:0060788 ectodermal placode formation GO:0060789 hair follicle placode formation GO:0060996 dendritic spine development GO:0060998 regulation of dendritic spine development GO:0061000 negative regulation of dendritic spine development GO:0061029 eyelid development in camera-type eye GO:0061196 fungiform papilla development GO:0061197 fungiform papilla morphogenesis GO:0061198 fungiform papilla formation GO:0070301 cellular response to hydrogen peroxide GO:0070482 response to oxygen levels GO:0070932 histone H3 deacetylation GO:0070933 histone H4 deacetylation GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071696 ectodermal placode development GO:0071697 ectodermal placode morphogenesis GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071867 response to monoamine GO:0071868 cellular response to monoamine stimulus GO:0071869 response to catecholamine GO:0071870 cellular response to catecholamine stimulus GO:0072331 signal transduction by p53 class mediator GO:0090596 sensory organ morphogenesis GO:0097305 response to alcohol GO:0097696 STAT cascade GO:0098732 macromolecule deacylation GO:0098773 skin epidermis development GO:1901796 regulation of signal transduction by p53 class mediator GO:1901983 regulation of protein acetylation GO:1901984 negative regulation of protein acetylation GO:1903350 response to dopamine GO:1903351 cellular response to dopamine GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:2000171 negative regulation of dendrite development GO:2000756 regulation of peptidyl-lysine acetylation GO:2000757 negative regulation of peptidyl-lysine acetylation
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001047 core promoter binding GO:0001085 RNA polymerase II transcription factor binding GO:0001103 RNA polymerase II repressing transcription factor binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0031072 heat shock protein binding GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity GO:0035326 enhancer binding GO:0043566 structure-specific DNA binding GO:0051059 NF-kappaB binding GO:0070491 repressing transcription factor binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0016580 Sin3 complex GO:0016581 NuRD complex GO:0017053 transcriptional repressor complex GO:0031519 PcG protein complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0035098 ESC/E(Z) complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0070822 Sin3-type complex GO:0090545 CHD-type complex GO:0090568 nuclear transcriptional repressor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04110 Cell cycle hsa04330 Notch signaling pathway hsa04919 Thyroid hormone signaling pathway
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214815: HDACs deacetylate histones R-HSA-109582: Hemostasis R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-427413: NoRC negatively regulates rRNA expression R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73864: RNA Polymerase I Transcription R-HSA-73762: RNA Polymerase I Transcription Initiation R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804758: Regulation of TP53 Activity through Acetylation R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-166520: Signalling by NGF R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-193704: p75 NTR receptor-mediated signalling R-HSA-193670: p75NTR negatively regulates cell cycle via SC1

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04110 Cell cycle
hsa04330 Notch signaling pathway
hsa04919 Thyroid hormone signaling pathway

Reactome

R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214815: HDACs deacetylate histones
R-HSA-109582: Hemostasis
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-5250941: Negative epigenetic regulation of rRNA expression
R-HSA-427413: NoRC negatively regulates rRNA expression
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804758: Regulation of TP53 Activity through Acetylation
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-166520: Signalling by NGF
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-193704: p75 NTR receptor-mediated signalling
R-HSA-193670: p75NTR negatively regulates cell cycle via SC1

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1197594	c.82G>T	p.G28C	Substitution - Missense	Lung
COSM4689670	c.379C>T	p.R127*	Substitution - Nonsense	Large_intestine
COSM1209373	c.1213A>G	p.R405G	Substitution - Missense	Large_intestine
COSM5558090	c.1370A>G	p.K457R	Substitution - Missense	Prostate
COSM5558575	c.419T>C	p.L140S	Substitution - Missense	Prostate
COSM4615765	c.33_34insA	p.V12fs*8	Insertion - Frameshift	Large_intestine
COSM5558575	c.419T>C	p.L140S	Substitution - Missense	Prostate
COSM1439941	c.1375delA	p.T459fs*>30	Deletion - Frameshift	Large_intestine
COSM1194952	c.1276G>T	p.D426Y	Substitution - Missense	Lung
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM39117	c.498G>C	p.K166N	Substitution - Missense	Central_nervous_system
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM4805933	c.754A>T	p.M252L	Substitution - Missense	Liver
COSM1439941	c.1375delA	p.T459fs*>30	Deletion - Frameshift	Large_intestine
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Prostate
COSM1072324	c.321C>A	p.L107L	Substitution - coding silent	Endometrium
COSM1439947	c.875T>G	p.F292C	Substitution - Missense	Large_intestine
COSM450362	c.502C>T	p.H168Y	Substitution - Missense	Breast
COSM1254006	c.1273G>C	p.E425Q	Substitution - Missense	Oesophagus
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Stomach
COSM1672692	c.562T>G	p.F188V	Substitution - Missense	Large_intestine
COSM4779229	c.758A>G	p.Y253C	Substitution - Missense	Liver
COSM1439941	c.1375delA	p.T459fs*>30	Deletion - Frameshift	Large_intestine
COSM5811339	c.127C>T	p.L43L	Substitution - coding silent	Liver
COSM3857698	c.917T>A	p.I306N	Substitution - Missense	Stomach
COSM1754443	c.588G>A	p.T196T	Substitution - coding silent	Urinary_tract
COSM23305	c.1225C>T	p.R409*	Substitution - Nonsense	Skin
COSM1568123	c.348C>T	p.G116G	Substitution - coding silent	Large_intestine
COSM4760351	c.512T>A	p.V171D	Substitution - Missense	Stomach
COSM1072315	c.842-10_842-8delCTT	p.?	Unknown	Endometrium
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM1439941	c.1375delA	p.T459fs*>30	Deletion - Frameshift	Large_intestine
COSM23305	c.1225C>T	p.R409*	Substitution - Nonsense	Skin
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM392468	c.1375_1376insA	p.T459fs*4	Insertion - Frameshift	Lung
COSM5558575	c.419T>C	p.L140S	Substitution - Missense	Prostate
COSM88572	c.325G>C	p.E109Q	Substitution - Missense	Ovary
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM3777037	c.610G>A	p.E204K	Substitution - Missense	Urinary_tract
COSM132700	c.782A>C	p.Q261P	Substitution - Missense	Central_nervous_system
COSM5756730	c.577C>T	p.R193C	Substitution - Missense	Large_intestine
COSM3857696	c.1043C>A	p.P348H	Substitution - Missense	Stomach
COSM5986326	c.1061A>T	p.Q354L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5494421	c.44A>G	p.Y15C	Substitution - Missense	Biliary_tract
COSM340255	c.193A>G	p.M65V	Substitution - Missense	Lung
COSM5813814	c.433A>T	p.K145*	Substitution - Nonsense	Liver
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Pancreas
COSM4689668	c.1097G>A	p.R366H	Substitution - Missense	Large_intestine
COSM1672694	c.461T>C	p.V154A	Substitution - Missense	Large_intestine
COSM3156882	c.829C>A	p.L277I	Substitution - Missense	Large_intestine
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM4689674	c.32_33delAA	p.K11fs*8	Deletion - Frameshift	Biliary_tract
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM1754443	c.588G>A	p.T196T	Substitution - coding silent	Urinary_tract
COSM308044	c.232C>T	p.R78W	Substitution - Missense	Bone
COSM3429896	c.1001A>G	p.Y334C	Substitution - Missense	Large_intestine
COSM1072312	c.884C>T	p.P295L	Substitution - Missense	Endometrium
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM5558575	c.419T>C	p.L140S	Substitution - Missense	Prostate
COSM4689672	c.141C>T	p.G47G	Substitution - coding silent	Large_intestine
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM5001092	c.578G>A	p.R193H	Substitution - Missense	Pancreas
COSM4689670	c.379C>T	p.R127*	Substitution - Nonsense	Large_intestine
COSM1439941	c.1375delA	p.T459fs*>30	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM6012437	c.821G>T	p.C274F	Substitution - Missense	Skin
COSM4965478	c.1447G>A	p.E483K	Substitution - Missense	Pancreas
COSM1725330	c.544G>C	p.D182H	Substitution - Missense	Liver
COSM5468269	c.619C>A	p.P207T	Substitution - Missense	Large_intestine
COSM3156892	c.479C>T	p.A160V	Substitution - Missense	Skin
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM5811813	c.885A>G	p.P295P	Substitution - coding silent	Liver
COSM5756730	c.577C>T	p.R193C	Substitution - Missense	Large_intestine
COSM392468	c.1375_1376insA	p.T459fs*4	Insertion - Frameshift	Upper_aerodigestive_tract
COSM3619629	c.81G>A	p.Q27Q	Substitution - coding silent	Skin
COSM1672692	c.562T>G	p.F188V	Substitution - Missense	Large_intestine
COSM3994563	c.1248T>G	p.A416A	Substitution - coding silent	Kidney
COSM5474866	c.892A>G	p.M298V	Substitution - Missense	Large_intestine
COSM6012439	c.432G>C	p.K144N	Substitution - Missense	Skin
COSM4615765	c.33_34insA	p.V12fs*8	Insertion - Frameshift	Large_intestine
COSM5404182	c.1030C>A	p.L344M	Substitution - Missense	Skin
COSM1672694	c.461T>C	p.V154A	Substitution - Missense	Breast
COSM4689674	c.32_33delAA	p.K11fs*8	Deletion - Frameshift	Large_intestine
COSM1197594	c.82G>T	p.G28C	Substitution - Missense	Lung
COSM4805933	c.754A>T	p.M252L	Substitution - Missense	Liver
COSM23305	c.1225C>T	p.R409*	Substitution - Nonsense	Endometrium
COSM5061349	c.1114C>T	p.R372C	Substitution - Missense	Stomach
COSM1209375	c.453C>A	p.F151L	Substitution - Missense	Large_intestine
COSM3410541	c.1016G>A	p.G339E	Substitution - Missense	Central_nervous_system
COSM3777037	c.610G>A	p.E204K	Substitution - Missense	Skin
COSM4945517	c.1089A>G	p.I363M	Substitution - Missense	Liver
COSM5180751	c.230T>C	p.L77P	Substitution - Missense	Large_intestine
COSM4520963	c.1086G>A	p.K362K	Substitution - coding silent	Skin
COSM483296	c.231A>G	p.L77L	Substitution - coding silent	Kidney
COSM3947911	c.1252G>A	p.D418N	Substitution - Missense	Lung
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM4609614	c.1086G>C	p.K362N	Substitution - Missense	Adrenal_gland
COSM4760353	c.422A>G	p.H141R	Substitution - Missense	Stomach
COSM450360	c.523G>A	p.D175N	Substitution - Missense	Breast
COSM1072318	c.744G>A	p.K248K	Substitution - coding silent	Endometrium
COSM302354	c.73_75delTAT	p.Y25delY	Deletion - In frame	Central_nervous_system
COSM4954947	c.1115G>A	p.R372H	Substitution - Missense	Liver
COSM1439941	c.1375delA	p.T459fs*>30	Deletion - Frameshift	Pancreas
COSM4460201	c.1156C>T	p.P386S	Substitution - Missense	Skin
COSM4954947	c.1115G>A	p.R372H	Substitution - Missense	Liver
COSM4915351	c.1311T>A	p.D437E	Substitution - Missense	Liver
COSM1194952	c.1276G>T	p.D426Y	Substitution - Missense	Lung
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM302352	c.1364_1365delAG	p.E455fs*7	Deletion - Frameshift	Central_nervous_system
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Stomach
COSM308044	c.232C>T	p.R78W	Substitution - Missense	Biliary_tract
COSM5964961	c.770C>T	p.A257V	Substitution - Missense	Breast
COSM1072321	c.601A>G	p.K201E	Substitution - Missense	Endometrium
COSM3410539	c.1171C>G	p.H391D	Substitution - Missense	Central_nervous_system
COSM5642948	c.216G>C	p.E72D	Substitution - Missense	Oesophagus
COSM1285330	c.941C>A	p.T314K	Substitution - Missense	Autonomic_ganglia
COSM330199	c.323_324delTT	p.F108fs*1	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1672694	c.461T>C	p.V154A	Substitution - Missense	Large_intestine
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM3156876	c.1125T>A	p.P375P	Substitution - coding silent	Large_intestine
COSM4611655	c.33delA	p.V12fs*20	Deletion - Frameshift	Large_intestine
COSM450360	c.523G>A	p.D175N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM242538	c.1240C>T	p.R414W	Substitution - Missense	Prostate
COSM5559444	c.1112T>C	p.L371S	Substitution - Missense	Prostate
COSM3429898	c.593C>A	p.S198*	Substitution - Nonsense	Large_intestine
COSM269299	c.284-2A>G	p.?	Unknown	Large_intestine
COSM23305	c.1225C>T	p.R409*	Substitution - Nonsense	Large_intestine
COSM4405321	c.297A>C	p.E99D	Substitution - Missense	Skin
COSM5571134	c.863T>C	p.V288A	Substitution - Missense	Prostate
COSM132701	c.542G>T	p.G181V	Substitution - Missense	Central_nervous_system
COSM391912	c.413delG	p.G138fs*28	Deletion - Frameshift	Lung
COSM1439943	c.1229C>T	p.A410V	Substitution - Missense	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for HDAC2.

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q92769	221	K	N6-acetyllysine	-	No	None detected
Q92769	262	C	S-nitrosocysteine	-	No	None detected
Q92769	274	C	S-nitrosocysteine	-	No	None detected
Q92769	394	S	Phosphoserine	-	No	None detected
Q92769	407	S	Phosphoserine	-	No	None detected
Q92769	422	S	Phosphoserine	-	No	None detected
Q92769	424	S	Phosphoserine	-	No	None detected

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.616	6.955	0.313	0.0343	NS
BRCA	Breast invasive carcinoma	112	1100	6.397	6.798	0.438	2.04e-10	NS
CESC	Cervical and endocervical cancers	3	306	6.604	7.098	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.367	7.158	0.745	2.92e-18	Over
ESCA	Esophageal carcinoma	11	185	6.327	6.791	0.55	0.00376	NS
GBM	Glioblastoma multiforme	5	166	6.139	6.4	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.43	6.61	0.227	0.0013	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.36	6.124	-0.289	2.14e-07	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.129	6.08	-0.104	0.236	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.927	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.308	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.899	5.013	0.152	0.105	NS
LUAD	Lung adenocarcinoma	59	517	6.046	6.473	0.472	1.75e-09	NS
LUSC	Lung squamous cell carcinoma	51	501	5.957	7.129	1.191	1.3e-43	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.822	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.35	6.225	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.561	6.545	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.359	6.603	0.124	0.312	NS
READ	Rectum adenocarcinoma	10	167	6.489	7.149	0.555	0.00317	NS
SARC	Sarcoma	2	263	6.39	6.724	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.019	6.302	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.123	6.681	0.47	8.67e-06	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.583	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.181	6.243	0.032	0.428	NS
THYM	Thymoma	2	120	6.654	6.83	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.73	7.15	0.42	0.000232	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	8.5
Autonomic ganglia	CHP212	7.5
Autonomic ganglia	IMR32	8.9
Autonomic ganglia	KELLY	8.1
Autonomic ganglia	KPNRTBM1	8.3
Autonomic ganglia	KPNSI9S	7.1
Autonomic ganglia	KPNYN	8.2
Autonomic ganglia	MHHNB11	8.4
Autonomic ganglia	NB1	8.3
Autonomic ganglia	NH6	8.3
Autonomic ganglia	SHSY5Y	8.2
Autonomic ganglia	SIMA	8.5
Autonomic ganglia	SKNAS	6.6
Autonomic ganglia	SKNBE2	8.4
Autonomic ganglia	SKNDZ	8.9
Autonomic ganglia	SKNFI	7.3
Autonomic ganglia	SKNSH	7.5
Biliary tract	HUCCT1	6.4
Biliary tract	HUH28	6.8
Biliary tract	SNU1079	6.9
Biliary tract	SNU1196	7.3
Biliary tract	SNU245	7.3
Biliary tract	SNU308	6.5
Biliary tract	SNU478	7.6
Bone	143B	7.6
Bone	A673	7.6
Bone	CADOES1	7.4
Bone	CAL78	6.7
Bone	G292CLONEA141B1	7.4
Bone	HOS	7.6
Bone	HS706T	6.7
Bone	HS737T	6.5
Bone	HS819T	6.3
Bone	HS821T	6.8
Bone	HS822T	6.2
Bone	HS863T	7
Bone	HS870T	7
Bone	HS888T	7
Bone	MG63	7.4
Bone	MHHES1	7.4
Bone	OUMS27	7.1
Bone	RDES	7.9
Bone	SJSA1	7.2
Bone	SKES1	8
Bone	SKNMC	8.1
Bone	SW1353	6.8
Bone	T173	6.6
Bone	TC71	7.8
Bone	U2OS	7.1
Breast	AU565	6.9
Breast	BT20	7.7
Breast	BT474	7.4
Breast	BT483	6.5
Breast	BT549	7.3
Breast	CAL120	7.9
Breast	CAL148	7.9
Breast	CAL51	7.4
Breast	CAL851	6.9
Breast	CAMA1	6.4
Breast	DU4475	7.4
Breast	EFM192A	6.9
Breast	EFM19	7.8
Breast	EVSAT	7.7
Breast	HCC1143	6.8
Breast	HCC1187	7.5
Breast	HCC1395	7.2
Breast	HCC1419	7
Breast	HCC1428	6.3
Breast	HCC1500	7.1
Breast	HCC1569	6.9
Breast	HCC1599	7.5
Breast	HCC1806	6.7
Breast	HCC1937	6.8
Breast	HCC1954	7
Breast	HCC202	6
Breast	HCC2157	7.2
Breast	HCC2218	6.8
Breast	HCC38	6.7
Breast	HCC70	6.8
Breast	HDQP1	7.6
Breast	HMC18	7.3
Breast	HS274T	6.5
Breast	HS281T	6.8
Breast	HS343T	6.9
Breast	HS578T	6.3
Breast	HS606T	6.7
Breast	HS739T	6.7
Breast	HS742T	6.5
Breast	JIMT1	6.4
Breast	KPL1	6.7
Breast	MCF7	6.8
Breast	MDAMB134VI	7.9
Breast	MDAMB157	7.4
Breast	MDAMB175VII	6.2
Breast	MDAMB231	7
Breast	MDAMB361	7.3
Breast	MDAMB415	6.4
Breast	MDAMB436	7.1
Breast	MDAMB453	7.4
Breast	MDAMB468	8
Breast	SKBR3	6.9
Breast	T47D	6.1
Breast	UACC812	6.8
Breast	UACC893	7.3
Breast	YMB1	5.9
Breast	ZR751	6.2
Breast	ZR7530	6.6
Central nervous system	1321N1	7.6
Central nervous system	42MGBA	7.3
Central nervous system	8MGBA	6.8
Central nervous system	A172	7.1
Central nervous system	AM38	7.7
Central nervous system	BECKER	6.9
Central nervous system	CAS1	7.5
Central nervous system	CCFSTTG1	7
Central nervous system	D283MED	8.2
Central nervous system	D341MED	8.3
Central nervous system	DAOY	7.4
Central nervous system	DBTRG05MG	7
Central nervous system	DKMG	6.8
Central nervous system	GAMG	7.2
Central nervous system	GB1	7.4
Central nervous system	GI1	7.2
Central nervous system	GMS10	7
Central nervous system	GOS3	6.1
Central nervous system	H4	6.3
Central nervous system	HS683	6.9
Central nervous system	KALS1	7.5
Central nervous system	KG1C	6.4
Central nervous system	KNS42	7.6
Central nervous system	KNS60	6.6
Central nervous system	KNS81	7
Central nervous system	KS1	7.4
Central nervous system	LN18	6.9
Central nervous system	LN229	6.7
Central nervous system	M059K	7.4
Central nervous system	MOGGCCM	7.1
Central nervous system	MOGGUVW	6.6
Central nervous system	NMCG1	7.3
Central nervous system	ONS76	6.8
Central nervous system	SF126	7.1
Central nervous system	SF295	7.2
Central nervous system	SNB19	7.7
Central nervous system	SNU1105	7.1
Central nervous system	SNU201	6.9
Central nervous system	SNU466	6.1
Central nervous system	SNU489	6.4
Central nervous system	SNU626	7.1
Central nervous system	SNU738	6.6
Central nervous system	SW1088	6.9
Central nervous system	SW1783	7.1
Central nervous system	T98G	6.8
Central nervous system	TM31	7.1
Central nervous system	U118MG	7.2
Central nervous system	U138MG	6.6
Central nervous system	U251MG	6.9
Central nervous system	U87MG	6.9
Central nervous system	YH13	6.9
Central nervous system	YKG1	7.3
Endometrium	AN3CA	7.8
Endometrium	COLO684	7.5
Endometrium	EFE184	7
Endometrium	EN	7.5
Endometrium	ESS1	7.3
Endometrium	HEC108	6.9
Endometrium	HEC151	7.2
Endometrium	HEC1A	7.5
Endometrium	HEC1B	7.2
Endometrium	HEC251	7.5
Endometrium	HEC265	7.6
Endometrium	HEC50B	7.2
Endometrium	HEC59	6.7
Endometrium	HEC6	7.7
Endometrium	ISHIKAWAHERAKLIO02ER	7.3
Endometrium	JHUEM1	6.9
Endometrium	JHUEM2	7.7
Endometrium	JHUEM3	7.2
Endometrium	KLE	7
Endometrium	MFE280	7.2
Endometrium	MFE296	7.1
Endometrium	MFE319	7.1
Endometrium	RL952	5.2
Endometrium	SNGM	7.3
Endometrium	SNU1077	7.5
Endometrium	SNU685	7.2
Endometrium	TEN	7.1
Haematopoietic and lymphoid	697	7.2
Haematopoietic and lymphoid	A3KAW	7.1
Haematopoietic and lymphoid	A4FUK	7.2
Haematopoietic and lymphoid	ALLSIL	7.9
Haematopoietic and lymphoid	AML193	8
Haematopoietic and lymphoid	AMO1	7.2
Haematopoietic and lymphoid	BCP1	7.3
Haematopoietic and lymphoid	BDCM	7.1
Haematopoietic and lymphoid	BL41	7.2
Haematopoietic and lymphoid	BL70	7
Haematopoietic and lymphoid	BV173	7.5
Haematopoietic and lymphoid	CA46	7
Haematopoietic and lymphoid	CI1	6.8
Haematopoietic and lymphoid	CMK115	7.2
Haematopoietic and lymphoid	CMK86	7.7
Haematopoietic and lymphoid	CMK	7.6
Haematopoietic and lymphoid	CMLT1	7.5
Haematopoietic and lymphoid	COLO775	6.3
Haematopoietic and lymphoid	DAUDI	6.1
Haematopoietic and lymphoid	DB	7.6
Haematopoietic and lymphoid	DEL	6.6
Haematopoietic and lymphoid	DND41	7.7
Haematopoietic and lymphoid	DOHH2	7
Haematopoietic and lymphoid	EB1	6.9
Haematopoietic and lymphoid	EB2	6.3
Haematopoietic and lymphoid	EHEB	6.6
Haematopoietic and lymphoid	EJM	6.3
Haematopoietic and lymphoid	EM2	8.6
Haematopoietic and lymphoid	EOL1	8
Haematopoietic and lymphoid	F36P	7.8
Haematopoietic and lymphoid	GA10	7.2
Haematopoietic and lymphoid	GDM1	7.4
Haematopoietic and lymphoid	GRANTA519	6.8
Haematopoietic and lymphoid	HDLM2	6.8
Haematopoietic and lymphoid	HDMYZ	7.4
Haematopoietic and lymphoid	HEL9217	7.9
Haematopoietic and lymphoid	HEL	7.7
Haematopoietic and lymphoid	HH	6.7
Haematopoietic and lymphoid	HL60	7.6
Haematopoietic and lymphoid	HPBALL	7.9
Haematopoietic and lymphoid	HS604T	6.3
Haematopoietic and lymphoid	HS611T	6.6
Haematopoietic and lymphoid	HS616T	6.6
Haematopoietic and lymphoid	HS751T	6.9
Haematopoietic and lymphoid	HT	7.1
Haematopoietic and lymphoid	HTK	7.6
Haematopoietic and lymphoid	HUNS1	7.4
Haematopoietic and lymphoid	HUT102	6.8
Haematopoietic and lymphoid	HUT78	7.5
Haematopoietic and lymphoid	JEKO1	6.8
Haematopoietic and lymphoid	JK1	7.4
Haematopoietic and lymphoid	JM1	7.5
Haematopoietic and lymphoid	JURKAT	7.1
Haematopoietic and lymphoid	JURLMK1	7.2
Haematopoietic and lymphoid	JVM2	6.8
Haematopoietic and lymphoid	JVM3	6.7
Haematopoietic and lymphoid	K562	7.1
Haematopoietic and lymphoid	KARPAS299	6.3
Haematopoietic and lymphoid	KARPAS422	7.3
Haematopoietic and lymphoid	KARPAS620	7.6
Haematopoietic and lymphoid	KASUMI1	8.3
Haematopoietic and lymphoid	KASUMI2	6.8
Haematopoietic and lymphoid	KASUMI6	7
Haematopoietic and lymphoid	KCL22	7.6
Haematopoietic and lymphoid	KE37	8.1
Haematopoietic and lymphoid	KE97	7.5
Haematopoietic and lymphoid	KG1	7.7
Haematopoietic and lymphoid	KHM1B	7
Haematopoietic and lymphoid	KIJK	7.6
Haematopoietic and lymphoid	KMH2	6.9
Haematopoietic and lymphoid	KMM1	7.1
Haematopoietic and lymphoid	KMS11	6.8
Haematopoietic and lymphoid	KMS12BM	7.7
Haematopoietic and lymphoid	KMS18	7.2
Haematopoietic and lymphoid	KMS20	7.1
Haematopoietic and lymphoid	KMS21BM	6.5
Haematopoietic and lymphoid	KMS26	6.7
Haematopoietic and lymphoid	KMS27	5.9
Haematopoietic and lymphoid	KMS28BM	7
Haematopoietic and lymphoid	KMS34	7.2
Haematopoietic and lymphoid	KO52	7.5
Haematopoietic and lymphoid	KOPN8	7
Haematopoietic and lymphoid	KU812	8.5
Haematopoietic and lymphoid	KYO1	6.6
Haematopoietic and lymphoid	L1236	6.7
Haematopoietic and lymphoid	L363	6.1
Haematopoietic and lymphoid	L428	8.3
Haematopoietic and lymphoid	L540	6.5
Haematopoietic and lymphoid	LAMA84	7.7
Haematopoietic and lymphoid	LOUCY	8.5
Haematopoietic and lymphoid	LP1	6.2
Haematopoietic and lymphoid	M07E	8.2
Haematopoietic and lymphoid	MC116	6.9
Haematopoietic and lymphoid	ME1	7.2
Haematopoietic and lymphoid	MEC1	6.6
Haematopoietic and lymphoid	MEC2	6.4
Haematopoietic and lymphoid	MEG01	7.8
Haematopoietic and lymphoid	MHHCALL2	7.5
Haematopoietic and lymphoid	MHHCALL3	6.6
Haematopoietic and lymphoid	MHHCALL4	7.6
Haematopoietic and lymphoid	MINO	7.5
Haematopoietic and lymphoid	MJ	7.8
Haematopoietic and lymphoid	MM1S	7.1
Haematopoietic and lymphoid	MOLM13	8
Haematopoietic and lymphoid	MOLM16	7.7
Haematopoietic and lymphoid	MOLM6	7.1
Haematopoietic and lymphoid	MOLP2	5.9
Haematopoietic and lymphoid	MOLP8	7
Haematopoietic and lymphoid	MOLT13	8
Haematopoietic and lymphoid	MOLT16	7.4
Haematopoietic and lymphoid	MOLT4	7.6
Haematopoietic and lymphoid	MONOMAC1	7.1
Haematopoietic and lymphoid	MONOMAC6	7.6
Haematopoietic and lymphoid	MOTN1	6.3
Haematopoietic and lymphoid	MUTZ5	7.8
Haematopoietic and lymphoid	MV411	7.9
Haematopoietic and lymphoid	NALM19	7.4
Haematopoietic and lymphoid	NALM1	7.4
Haematopoietic and lymphoid	NALM6	7.2
Haematopoietic and lymphoid	NAMALWA	7.9
Haematopoietic and lymphoid	NB4	7.8
Haematopoietic and lymphoid	NCIH929	7.2
Haematopoietic and lymphoid	NCO2	8.1
Haematopoietic and lymphoid	NOMO1	7.4
Haematopoietic and lymphoid	NUDHL1	6.3
Haematopoietic and lymphoid	NUDUL1	7.3
Haematopoietic and lymphoid	OCIAML2	7.5
Haematopoietic and lymphoid	OCIAML3	6.8
Haematopoietic and lymphoid	OCIAML5	7.3
Haematopoietic and lymphoid	OCILY10	7.8
Haematopoietic and lymphoid	OCILY19	6.3
Haematopoietic and lymphoid	OCILY3	7.2
Haematopoietic and lymphoid	OCIM1	8
Haematopoietic and lymphoid	OPM2	6.8
Haematopoietic and lymphoid	P12ICHIKAWA	7.9
Haematopoietic and lymphoid	P31FUJ	7.2
Haematopoietic and lymphoid	P3HR1	7.1
Haematopoietic and lymphoid	PCM6	5.9
Haematopoietic and lymphoid	PEER	6.4
Haematopoietic and lymphoid	PF382	7.5
Haematopoietic and lymphoid	PFEIFFER	6.9
Haematopoietic and lymphoid	PL21	7.5
Haematopoietic and lymphoid	RAJI	7.7
Haematopoietic and lymphoid	RCHACV	8.3
Haematopoietic and lymphoid	REC1	7
Haematopoietic and lymphoid	REH	7.7
Haematopoietic and lymphoid	RI1	6.9
Haematopoietic and lymphoid	RL	6.8
Haematopoietic and lymphoid	RPMI8226	6.4
Haematopoietic and lymphoid	RPMI8402	8
Haematopoietic and lymphoid	RS411	7.5
Haematopoietic and lymphoid	SEM	7.8
Haematopoietic and lymphoid	SET2	7.5
Haematopoietic and lymphoid	SIGM5	7.5
Haematopoietic and lymphoid	SKM1	7.4
Haematopoietic and lymphoid	SKMM2	6.3
Haematopoietic and lymphoid	SR786	7
Haematopoietic and lymphoid	ST486	7.2
Haematopoietic and lymphoid	SUDHL10	7.1
Haematopoietic and lymphoid	SUDHL1	7.2
Haematopoietic and lymphoid	SUDHL4	7
Haematopoietic and lymphoid	SUDHL5	6.1
Haematopoietic and lymphoid	SUDHL6	7.5
Haematopoietic and lymphoid	SUDHL8	7.8
Haematopoietic and lymphoid	SUPB15	7.5
Haematopoietic and lymphoid	SUPHD1	6.7
Haematopoietic and lymphoid	SUPM2	7
Haematopoietic and lymphoid	SUPT11	7.3
Haematopoietic and lymphoid	SUPT1	6.6
Haematopoietic and lymphoid	TALL1	8
Haematopoietic and lymphoid	TF1	7.8
Haematopoietic and lymphoid	THP1	7.4
Haematopoietic and lymphoid	TO175T	6.6
Haematopoietic and lymphoid	TOLEDO	7.3
Haematopoietic and lymphoid	U266B1	6.5
Haematopoietic and lymphoid	U937	7.3
Haematopoietic and lymphoid	UT7	7.9
Haematopoietic and lymphoid	WSUDLCL2	7.1
Kidney	769P	7.2
Kidney	786O	6.8
Kidney	A498	6.1
Kidney	A704	6.5
Kidney	ACHN	6.9
Kidney	BFTC909	6.8
Kidney	CAKI1	6.5
Kidney	CAKI2	6.6
Kidney	CAL54	7.3
Kidney	KMRC1	7
Kidney	KMRC20	6.8
Kidney	KMRC2	7.3
Kidney	KMRC3	5.5
Kidney	OSRC2	6.1
Kidney	RCC10RGB	6
Kidney	SNU1272	7.3
Kidney	SNU349	6.8
Kidney	TUHR10TKB	6.8
Kidney	TUHR14TKB	6.2
Kidney	TUHR4TKB	6.5
Kidney	VMRCRCW	6.1
Kidney	VMRCRCZ	7.3
Large intestine	C2BBE1	7.8
Large intestine	CCK81	7.4
Large intestine	CL11	8.2
Large intestine	CL14	8.3
Large intestine	CL34	7.2
Large intestine	CL40	7.7
Large intestine	COLO205	6.5
Large intestine	COLO320	8
Large intestine	COLO678	6.6
Large intestine	CW2	7.1
Large intestine	DLD1	7.4
Large intestine	GP2D	7.2
Large intestine	HCC56	6.7
Large intestine	HCT116	7.8
Large intestine	HCT15	7.7
Large intestine	HS675T	6.5
Large intestine	HS698T	6.9
Large intestine	HT115	7.3
Large intestine	HT29	7.6
Large intestine	HT55	7.5
Large intestine	KM12	7.6
Large intestine	LOVO	7.6
Large intestine	LS1034	7.3
Large intestine	LS123	7.3
Large intestine	LS180	7.6
Large intestine	LS411N	7.7
Large intestine	LS513	7.4
Large intestine	MDST8	7.1
Large intestine	NCIH508	7
Large intestine	NCIH716	7.1
Large intestine	NCIH747	7.1
Large intestine	OUMS23	7.4
Large intestine	RCM1	7
Large intestine	RKO	7
Large intestine	SKCO1	8.4
Large intestine	SNU1040	7.5
Large intestine	SNU1197	7
Large intestine	SNU175	7.5
Large intestine	SNU283	6.9
Large intestine	SNU407	7.5
Large intestine	SNU503	7
Large intestine	SNU61	7
Large intestine	SNU81	6
Large intestine	SNUC1	7.2
Large intestine	SNUC2A	7.6
Large intestine	SNUC4	7.4
Large intestine	SNUC5	7.5
Large intestine	SW1116	6.7
Large intestine	SW1417	6.3
Large intestine	SW1463	7.1
Large intestine	SW403	7.3
Large intestine	SW480	7
Large intestine	SW48	8
Large intestine	SW620	8
Large intestine	SW837	7.3
Large intestine	SW948	7.3
Large intestine	T84	7.7
Liver	ALEXANDERCELLS	7.4
Liver	C3A	7.3
Liver	HEP3B217	7.6
Liver	HEPG2	7.1
Liver	HLE	7.9
Liver	HLF	7.6
Liver	HUH1	7.1
Liver	HUH6	7.4
Liver	HUH7	8
Liver	JHH1	6.7
Liver	JHH2	7.3
Liver	JHH4	7.2
Liver	JHH5	7.1
Liver	JHH6	7
Liver	JHH7	7.8
Liver	LI7	7.1
Liver	PLCPRF5	7.3
Liver	SKHEP1	7.1
Liver	SNU182	7.1
Liver	SNU387	7.4
Liver	SNU398	7.4
Liver	SNU423	7.7
Liver	SNU449	7
Liver	SNU475	6.8
Liver	SNU761	6.9
Liver	SNU878	7
Liver	SNU886	7
Lung	A549	7.1
Lung	ABC1	7.2
Lung	BEN	6.9
Lung	CAL12T	6.7
Lung	CALU1	7.4
Lung	CALU3	7.7
Lung	CALU6	6.8
Lung	CHAGOK1	7.1
Lung	COLO668	7.2
Lung	COLO699	7.5
Lung	CORL105	6.7
Lung	CORL23	7.3
Lung	CORL24	8.5
Lung	CORL279	8.5
Lung	CORL311	8.6
Lung	CORL47	7.2
Lung	CORL51	8.2
Lung	CORL88	8.2
Lung	CORL95	7.5
Lung	CPCN	8.3
Lung	DMS114	7.8
Lung	DMS153	8
Lung	DMS273	8
Lung	DMS454	6.9
Lung	DMS53	7.1
Lung	DMS79	8.5
Lung	DV90	7.6
Lung	EBC1	6.9
Lung	EPLC272H	6.2
Lung	HARA	7
Lung	HCC1171	6.9
Lung	HCC1195	6.5
Lung	HCC15	6.9
Lung	HCC2279	7.4
Lung	HCC2935	7.1
Lung	HCC33	8.3
Lung	HCC366	7.2
Lung	HCC4006	7
Lung	HCC44	7.3
Lung	HCC78	7.1
Lung	HCC827	6.9
Lung	HCC95	7.1
Lung	HLC1	7.2
Lung	HLFA	6.8
Lung	HS229T	7.3
Lung	HS618T	6.9
Lung	IALM	6.9
Lung	KNS62	7.4
Lung	LC1F	7
Lung	LC1SQSF	6.8
Lung	LCLC103H	6.9
Lung	LCLC97TM1	6.9
Lung	LK2	8.3
Lung	LOUNH91	6.9
Lung	LU65	7.8
Lung	LU99	7.2
Lung	LUDLU1	6.6
Lung	LXF289	6.6
Lung	MORCPR	7.4
Lung	NCIH1048	7.8
Lung	NCIH1092	8.3
Lung	NCIH1105	9
Lung	NCIH1155	8.4
Lung	NCIH1184	8.4
Lung	NCIH1299	7.6
Lung	NCIH1339	7.7
Lung	NCIH1341	7.5
Lung	NCIH1355	7
Lung	NCIH1373	7
Lung	NCIH1385	7.3
Lung	NCIH1395	5.3
Lung	NCIH1435	6.6
Lung	NCIH1436	8.5
Lung	NCIH1437	6.5
Lung	NCIH146	8.2
Lung	NCIH1563	6.4
Lung	NCIH1568	7.5
Lung	NCIH1573	6.1
Lung	NCIH1581	7.7
Lung	NCIH1618	8.5
Lung	NCIH1623	5.5
Lung	NCIH1648	7.5
Lung	NCIH1650	6.1
Lung	NCIH1651	6.3
Lung	NCIH1666	7.1
Lung	NCIH1693	7.5
Lung	NCIH1694	8
Lung	NCIH1703	7.4
Lung	NCIH1734	7.8
Lung	NCIH1755	6.9
Lung	NCIH1781	7.8
Lung	NCIH1792	7.5
Lung	NCIH1793	6.5
Lung	NCIH1836	8.2
Lung	NCIH1838	6.6
Lung	NCIH1869	6.6
Lung	NCIH1876	9.1
Lung	NCIH1915	7.4
Lung	NCIH1930	7.9
Lung	NCIH1944	7.1
Lung	NCIH1963	8.2
Lung	NCIH196	6.8
Lung	NCIH1975	6.6
Lung	NCIH2009	7.8
Lung	NCIH2023	6.9
Lung	NCIH2029	8.5
Lung	NCIH2030	7.1
Lung	NCIH2066	7.6
Lung	NCIH2081	7.9
Lung	NCIH2085	6.6
Lung	NCIH2087	6.5
Lung	NCIH209	6.2
Lung	NCIH2106	7.7
Lung	NCIH2110	7.7
Lung	NCIH211	8.3
Lung	NCIH2122	6.9
Lung	NCIH2126	6.4
Lung	NCIH2141	8.4
Lung	NCIH2170	8.1
Lung	NCIH2171	8.3
Lung	NCIH2172	7.2
Lung	NCIH2196	7.9
Lung	NCIH2227	8
Lung	NCIH2228	6.6
Lung	NCIH226	6.7
Lung	NCIH2286	7
Lung	NCIH2291	7.1
Lung	NCIH2342	7.4
Lung	NCIH2347	6.7
Lung	NCIH23	7
Lung	NCIH2405	7.1
Lung	NCIH2444	7.1
Lung	NCIH292	6.9
Lung	NCIH322	7.2
Lung	NCIH3255	7
Lung	NCIH358	6.9
Lung	NCIH441	6.9
Lung	NCIH446	7.8
Lung	NCIH460	7
Lung	NCIH510	6.9
Lung	NCIH520	8
Lung	NCIH522	8.1
Lung	NCIH524	8.1
Lung	NCIH526	8.1
Lung	NCIH596	6.4
Lung	NCIH647	7.3
Lung	NCIH650	7.6
Lung	NCIH661	7.7
Lung	NCIH69	7.3
Lung	NCIH727	7.4
Lung	NCIH810	7.2
Lung	NCIH82	8
Lung	NCIH838	7.6
Lung	NCIH841	7.7
Lung	NCIH854	7.6
Lung	NCIH889	7.7
Lung	PC14	7.3
Lung	RERFLCAD1	7
Lung	RERFLCAD2	7.2
Lung	RERFLCAI	7.7
Lung	RERFLCKJ	6.6
Lung	RERFLCMS	7
Lung	RERFLCSQ1	7.1
Lung	SBC5	7.2
Lung	SCLC21H	7.9
Lung	SHP77	7.5
Lung	SKLU1	6.3
Lung	SKMES1	7
Lung	SQ1	7.1
Lung	SW1271	7.2
Lung	SW1573	7.3
Lung	SW900	6.7
Lung	VMRCLCD	6.9
Lung	VMRCLCP	7.2
Oesophagus	COLO680N	6.9
Oesophagus	ECGI10	7
Oesophagus	KYSE140	7.8
Oesophagus	KYSE150	7
Oesophagus	KYSE180	6.6
Oesophagus	KYSE270	6.5
Oesophagus	KYSE30	7
Oesophagus	KYSE410	7.9
Oesophagus	KYSE450	7.1
Oesophagus	KYSE510	7.9
Oesophagus	KYSE520	6.8
Oesophagus	KYSE70	6.5
Oesophagus	OE19	7.1
Oesophagus	OE33	8.1
Oesophagus	TE10	7.2
Oesophagus	TE11	6.7
Oesophagus	TE14	7.4
Oesophagus	TE15	7.1
Oesophagus	TE1	6.8
Oesophagus	TE4	7.1
Oesophagus	TE5	7.2
Oesophagus	TE6	6.8
Oesophagus	TE8	7.1
Oesophagus	TE9	6.9
Oesophagus	TT	6.3
Ovary	59M	7.4
Ovary	A2780	7.1
Ovary	CAOV3	6.8
Ovary	CAOV4	6
Ovary	COLO704	7.5
Ovary	COV318	7.3
Ovary	COV362	6.7
Ovary	COV434	7.8
Ovary	COV504	7.1
Ovary	COV644	7.8
Ovary	EFO21	6.6
Ovary	EFO27	6.7
Ovary	ES2	7.8
Ovary	FUOV1	7.4
Ovary	HEYA8	7.5
Ovary	HS571T	6.3
Ovary	IGROV1	7.2
Ovary	JHOC5	7
Ovary	JHOM1	6.9
Ovary	JHOM2B	7.2
Ovary	JHOS2	6.8
Ovary	JHOS4	6.7
Ovary	KURAMOCHI	7.4
Ovary	MCAS	7.5
Ovary	NIHOVCAR3	7.2
Ovary	OAW28	8
Ovary	OAW42	7.4
Ovary	OC314	7.3
Ovary	OC316	7.6
Ovary	ONCODG1	7.5
Ovary	OV56	6.3
Ovary	OV7	7.3
Ovary	OV90	7.2
Ovary	OVCAR4	6.9
Ovary	OVCAR8	8.4
Ovary	OVISE	6.8
Ovary	OVK18	7.1
Ovary	OVKATE	6.3
Ovary	OVMANA	6.7
Ovary	OVSAHO	6.8
Ovary	OVTOKO	6.8
Ovary	RMGI	6.6
Ovary	RMUGS	5.7
Ovary	SKOV3	7.6
Ovary	SNU119	6.6
Ovary	SNU840	6.4
Ovary	SNU8	7.7
Ovary	TOV112D	8.3
Ovary	TOV21G	7.1
Ovary	TYKNU	6.2
Pancreas	ASPC1	6.5
Pancreas	BXPC3	6.7
Pancreas	CAPAN1	5.6
Pancreas	CAPAN2	6.4
Pancreas	CFPAC1	6.4
Pancreas	DANG	7.4
Pancreas	HPAC	6.9
Pancreas	HPAFII	7.1
Pancreas	HS766T	6.9
Pancreas	HUPT3	6.5
Pancreas	HUPT4	7
Pancreas	KCIMOH1	7.2
Pancreas	KLM1	6.6
Pancreas	KP2	6.6
Pancreas	KP3	6.3
Pancreas	KP4	7.8
Pancreas	L33	7
Pancreas	MIAPACA2	7.4
Pancreas	PANC0203	6.6
Pancreas	PANC0213	5.8
Pancreas	PANC0327	6.8
Pancreas	PANC0403	6.9
Pancreas	PANC0504	7
Pancreas	PANC0813	6.9
Pancreas	PANC1005	6.8
Pancreas	PANC1	7.6
Pancreas	PATU8902	7.5
Pancreas	PATU8988S	7
Pancreas	PATU8988T	7.8
Pancreas	PK1	6.7
Pancreas	PK45H	7.3
Pancreas	PK59	6.8
Pancreas	PL45	6.8
Pancreas	PSN1	7.2
Pancreas	QGP1	7.4
Pancreas	SNU213	7.2
Pancreas	SNU324	5.4
Pancreas	SNU410	6.6
Pancreas	SU8686	6.8
Pancreas	SUIT2	7.8
Pancreas	SW1990	7.1
Pancreas	T3M4	6.9
Pancreas	TCCPAN2	6.2
Pancreas	YAPC	7.6
Pleura	ACCMESO1	7
Pleura	DM3	6.7
Pleura	ISTMES1	7.5
Pleura	ISTMES2	6.4
Pleura	JL1	6.5
Pleura	MPP89	7.4
Pleura	MSTO211H	8.1
Pleura	NCIH2052	6.6
Pleura	NCIH2452	7.5
Pleura	NCIH28	7.8
Prostate	22RV1	7.3
Prostate	DU145	7
Prostate	LNCAPCLONEFGC	7.1
Prostate	MDAPCA2B	7.1
Prostate	NCIH660	8.3
Prostate	PC3	7
Prostate	VCAP	7.6
Salivary gland	A253	7.8
Salivary gland	YD15	6.4
Skin	A101D	6.6
Skin	A2058	7.1
Skin	A375	7.2
Skin	C32	7.1
Skin	CHL1	7.9
Skin	CJM	6.4
Skin	COLO679	7.5
Skin	COLO741	7.4
Skin	COLO783	6.8
Skin	COLO792	6.7
Skin	COLO800	6.7
Skin	COLO818	7
Skin	COLO829	6.6
Skin	COLO849	7
Skin	G361	6.9
Skin	GRM	7.2
Skin	HMCB	8.2
Skin	HS294T	6.5
Skin	HS600T	6.6
Skin	HS688AT	6.3
Skin	HS695T	6.2
Skin	HS839T	6.6
Skin	HS852T	6.7
Skin	HS895T	6.9
Skin	HS934T	6.7
Skin	HS936T	7
Skin	HS939T	7.3
Skin	HS940T	6.5
Skin	HS944T	7
Skin	HT144	6.8
Skin	IGR1	7.4
Skin	IGR37	6.9
Skin	IGR39	7.1
Skin	IPC298	7.1
Skin	K029AX	6.9
Skin	LOXIMVI	7.8
Skin	MALME3M	6.5
Skin	MDAMB435S	6.9
Skin	MELHO	7.3
Skin	MELJUSO	7.2
Skin	MEWO	8.1
Skin	RPMI7951	7.4
Skin	RVH421	6.9
Skin	SH4	6.4
Skin	SKMEL1	6.1
Skin	SKMEL24	6.9
Skin	SKMEL28	6.9
Skin	SKMEL2	7.3
Skin	SKMEL30	6.9
Skin	SKMEL31	6.8
Skin	SKMEL3	6.6
Skin	SKMEL5	7.2
Skin	UACC257	6.7
Skin	UACC62	6.9
Skin	WM115	7
Skin	WM1799	6.9
Skin	WM2664	6.9
Skin	WM793	7.2
Skin	WM88	7
Skin	WM983B	7.6
Small intestine	HUTU80	7.5
Soft tissue	A204	7.1
Soft tissue	G401	7.3
Soft tissue	G402	7.3
Soft tissue	GCT	7.6
Soft tissue	HS729	6.9
Soft tissue	HT1080	7.4
Soft tissue	KYM1	7.5
Soft tissue	MESSA	6.7
Soft tissue	RD	7.9
Soft tissue	RH30	7.8
Soft tissue	RH41	8.4
Soft tissue	RKN	6.5
Soft tissue	S117	7.2
Soft tissue	SJRH30	8.3
Soft tissue	SKLMS1	7.3
Soft tissue	SKUT1	7.2
Soft tissue	TE125T	7
Soft tissue	TE159T	6.5
Soft tissue	TE441T	7.8
Soft tissue	TE617T	7.9
Stomach	2313287	6.9
Stomach	AGS	8.2
Stomach	AZ521	7.8
Stomach	ECC10	8.5
Stomach	ECC12	6.9
Stomach	FU97	7.1
Stomach	GCIY	7.8
Stomach	GSS	8
Stomach	GSU	7.3
Stomach	HGC27	7.2
Stomach	HS746T	7.2
Stomach	HUG1N	7.1
Stomach	IM95	7.5
Stomach	KATOIII	7.6
Stomach	KE39	7.2
Stomach	LMSU	7.2
Stomach	MKN1	7.1
Stomach	MKN45	7.1
Stomach	MKN74	7.2
Stomach	MKN7	7.1
Stomach	NCCSTCK140	6.8
Stomach	NCIN87	7.7
Stomach	NUGC2	6.5
Stomach	NUGC3	7.8
Stomach	NUGC4	6.8
Stomach	OCUM1	7.5
Stomach	RERFGC1B	7.5
Stomach	SH10TC	7.2
Stomach	SNU16	7.5
Stomach	SNU1	7.8
Stomach	SNU216	7.1
Stomach	SNU520	6.5
Stomach	SNU5	7.1
Stomach	SNU601	7.7
Stomach	SNU620	7.2
Stomach	SNU668	7.2
Stomach	SNU719	7.4
Stomach	TGBC11TKB	7.7
Thyroid	8305C	6.9
Thyroid	8505C	7.7
Thyroid	BCPAP	5.9
Thyroid	BHT101	7.5
Thyroid	CAL62	7.3
Thyroid	CGTHW1	6.8
Thyroid	FTC133	7.3
Thyroid	FTC238	8.3
Thyroid	ML1	6.3
Thyroid	SW579	7.3
Thyroid	TT2609C02	7.3
Thyroid	TT	7.6
Upper aerodigestive tract	BHY	5.6
Upper aerodigestive tract	BICR16	6.6
Upper aerodigestive tract	BICR18	7
Upper aerodigestive tract	BICR22	6.7
Upper aerodigestive tract	BICR31	7.1
Upper aerodigestive tract	BICR56	7
Upper aerodigestive tract	BICR6	6.9
Upper aerodigestive tract	CAL27	6.8
Upper aerodigestive tract	CAL33	6.3
Upper aerodigestive tract	DETROIT562	7.1
Upper aerodigestive tract	FADU	7.3
Upper aerodigestive tract	HS840T	6.9
Upper aerodigestive tract	HSC2	7
Upper aerodigestive tract	HSC3	6.9
Upper aerodigestive tract	HSC4	6.7
Upper aerodigestive tract	PECAPJ15	7.1
Upper aerodigestive tract	PECAPJ34CLONEC12	7.2
Upper aerodigestive tract	PECAPJ41CLONED2	7.1
Upper aerodigestive tract	PECAPJ49	7.2
Upper aerodigestive tract	SCC15	6.7
Upper aerodigestive tract	SCC25	7
Upper aerodigestive tract	SCC4	6.9
Upper aerodigestive tract	SCC9	6.8
Upper aerodigestive tract	SNU1076	6.4
Upper aerodigestive tract	SNU1214	6.5
Upper aerodigestive tract	SNU46	6.7
Upper aerodigestive tract	SNU899	7
Upper aerodigestive tract	YD10B	6.5
Upper aerodigestive tract	YD38	6.9
Upper aerodigestive tract	YD8	7.3
Urinary tract	5637	7.7
Urinary tract	639V	7.4
Urinary tract	647V	7.3
Urinary tract	BC3C	7.4
Urinary tract	BFTC905	7.6
Urinary tract	CAL29	7.2
Urinary tract	HS172T	6.5
Urinary tract	HT1197	6.9
Urinary tract	HT1376	7.1
Urinary tract	J82	7.2
Urinary tract	JMSU1	7.5
Urinary tract	KMBC2	6.5
Urinary tract	KU1919	7.1
Urinary tract	RT11284	7.7
Urinary tract	RT112	7.4
Urinary tract	RT4	6.9
Urinary tract	SCABER	6.7
Urinary tract	SW1710	6.8
Urinary tract	SW780	6.8
Urinary tract	T24	6.9
Urinary tract	TCCSUP	7
Urinary tract	UMUC1	6.9
Urinary tract	UMUC3	7.9
Urinary tract	VMCUB1	6.8

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	41.9
Adrenal gland	56.2
Appendix	52.2
Bone marrow	39.4
Breast	67.5
Cerebral cortex	55.4
Cervix, uterine	68.8
Colon	48.7
Duodenum	35.4
Endometrium	95.8
Epididymis	63.6
Esophagus	45.8
Fallopian tube	77.8
Gallbladder	55
Heart muscle	27.6
Kidney	48.7
Liver	17.7
Lung	49.5
Lymph node	49.4
Ovary	65.5
Pancreas	7.3
Parathyroid gland	73.7
Placenta	80.2
Prostate	77.3
Rectum	60.7
Salivary gland	14.3
Seminal vesicle	63.1
Skeletal muscle	16.9
Skin	54.8
Small intestine	41.3
Smooth muscle	79.1
Spleen	50.5
Stomach	37.6
Testis	142
Thyroid gland	76
Tonsil	49.6
Urinary bladder	57.8

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
20049841	Overexpression	Ovarian Carcinoma	The results indicated that the immunohistochemical expression of nuclear HDAC1, HDAC2 and HDAC3 proteins increased stepwise in benign, borderline and malignant tumors.
21206745	Overexpression	Hepatocellular Carcinoma	Kaplan-Meier curves showed that a high expression level of HDAC2 or HDAC3 implicated significantly reduced recurrence-free survival.
22270866	Overexpression	Colorectal Carcinoma	The immunohistochemical staining of HDACs, including HDAC1, HDAC2, HDAC3, and HDAC4, was significantly increased in colorectal adenocarcinoma specimens compared to healthy control tissues.
22944197	Overexpression	Urothelial Carcinoma	Prominent changes in UCCs were HDAC2 and/or HDAC8 up-regulation in 11 of 18 cell lines and decreased expression of HDAC4, HDAC5, and/or HDAC7 mRNA in 15 of 18 cell lines.
23110995	Overexpression	Non-Small Cell Lung Cancer	Expression of HDAC1 and that of HDAC2 were correlated, and significantly higher in NSCLC tissues than in normal lung tissues (P<0.05).
26254420	Overexpression	Malignant Pleural Mesothelioma	In the Gordon Mesothelioma Study, 34 of them were assessed out of which SUMO1, UBC3, KIAA0101, HDAC2, DAXX, RBBP4, BBS1, NONO, RBBP7, HTRA2, and STUB1 were significantly overexpressed whereas TRAF6 and MTA2 were significantly underexpressed in MPM patients (network 2).
23420051	Overexpression	Ovarian Carcinoma	Furthermore, the expression of DNMT1, DNMT3b, HDAC1 and HDAC2 was significantly higher in stage III/IV compared with stage I/II ovarian carcinomas.
25139823	Overexpression	Breast Carcinoma	When the combined expression levels were analyzed, high expression of LSD1, HDAC2 and SIRT1 showed shorter patient survival time and shorter time to tumor relapse and correlated with poor tumor differentiation and a high level of tumor cell proliferation.
25076845	altered expression	Diffuse Large B-Cell Lymphoma	High nuclear expression of HDAC2 may play an important role in survival of DLBCL patients, especially in those with nodal lymphoma, which is associated with a shorter survival time.
24448241	Overexpression	Hepatocellular Carcinoma	In this study, we show that HDAC2 expression is upregulated in a large cohort of patients with human hepatocellular carcinoma, and that high expression of HDAC2 was significantly associated with poor prognosis of patients with hepatocellular carcinoma.
24010203	Overexpression	Prostate Carcinoma	HDAC1 and HDAC2 were expressed in 59.7 and 70.7% of the patients, respectively, located in the nuclei of cancer cells, more highly in those with higher than in those with lower Gleason scores (P < 0.05). Univariate analysis demonstrated that the HDAC2 expression, pre-operative PSA levels, Gleason scores and clinical stages of prostate cancer were important factors affecting the patients'survival (P < 0.05).
23544610	Overexpression	Oesophagal Squamous Cell Carcinoma	Expression of HDAC2 was significantly higher in ESCC than in adjacent non-tumor tissues.
23627572	Overexpression	Breast Carcinoma	HDAC2 and HDAC3 expression was significantly higher in less differentiated tumors: HDAC2 (n=207), p<0.001 and HDAC3 (n=220), p<0.001 and correlated with negative hormone receptor status: HDAC2 (n=206), p=0.02 and HDAC3 (n=219), p=0.04.
23175521	Overexpression	Gastric carcinoma	HDAC2 gene and protein expression was significantly upregulated in different histopathologic grades of human gastric cancers and cancer cell lines.
21713366	Overexpression	Hepatocellular Carcinoma	High HDAC2 expression was associated with poor survival in low-grade and early-stage tumors (p < 0.05).
23948281	Overexpression	Acute Lymphoid Leukemia	Correlation analysis of HDAC expression with clinicopathological parameters revealed that high HDAC1, HDAC2, HDAC4 and HDAC11 levels were significantly associated with unfavorable prognostic factors.
20924032	Overexpression	Oesophagal Adenoarcinoma	High HDAC2 expression is associated with aggressive tumour behaviour in oesophageal adenocarcinomas.
20178884	Overexpression	Endometrial Carcinoma	The positivity index for histone deacetylase 2 was significantly increased in higher-grade carcinomas (positivity index for grade 3, 124.9 +/- 28.4) compared with grade 1 tumors (86.0 +/- 41.0) and was positively correlated with that for Ki-67.
24441677	Overexpression	Lung Carcinoma	Finally, immunohistochemistry on human lung cancer specimens revealed a significant increase in DNMT1, HDAC1, HDAC2, and HDAC3 expression, supporting our hypotheses that class I HDACs are mediators of DNMT1 stability.
24668547	Overexpression	Gastric Carcinoma	On the other hand, upregulation of HDAC2, GCN5, and MYC was observed in gastric tumors compared with adjacent nontumors (P < 0.05).
25548579	Overexpression	Breast Carcinoma	Although the expression of HDACs did not exhibit prognostic significance in the entire cohort, high expression of HDAC1 and HDAC6 was associated with improved overall survival (OS) in patients with ER-positive tumors (p=0.017 and p=0.029, respectively), and high expression of HDAC2 was correlated with improved OS in ER-negative tumors (p=0.048) on univariate analysis.
26352599	Overexpression	Hepatocellular Carcinoma	We found that HDAC1 and HDAC2 were upregulated in the majority of HCC tissues.
27793800	Underexpression	Chronic Obstructive Pulmonary Disease	Our qPCR validation data revealed a significant downregulation of Dnmt1, Dnmt3a, Dnmt3b, Hdac2, Hdac4, Hat1, Prmt1, and Aurkb.
28600475	Overexpression	Thyroid Gland Undifferentiated (Anaplastic) Carcinoma; Thyroid Gland Carcinoma	HDAC2 was upregulated in ATC and other thyroid cancer histologic subtypes.
28260932	Underexpression	Chronic Lymphocytic Leukemia	The level of HDAC1 and HDAC7 mRNA expression was significantly increased (P=0.02 and P=0.008, respectively) and HDAC2 and P300 mRNA expression was reduced in patients with CLL (P=0.002 and P=0.001, respectively).
28262837	Overexpression	Hepatocellular Carcinoma	Low expression of FBP1 correlated with high levels of histone deacetylase 1 (HDAC1) and HDAC2 proteins in HCC patient tissues.
27832326	Overexpression	Glioblastoma	It showed that HDAC2 expression is significantly up-regulated in GBM cells.
27721407	Overexpression	Pancreatic Carcinoma	Here, we show that the class I histone deacetylases HDAC1 and HDAC2 contribute to maintain the expression of p53 mutants in human and genetically defined murine pancreatic cancer cells.
27705912	Overexpression	Cholangiocarcinoma	In this study, we found that expression of HDACs 2, 3, and 8 were up-regulated in CCA tissues and those patients with high expression of HDAC2 and/or HDAC3 had a worse prognosis.
27665474	Overexpression	Non-small Cell Lung Carcinoma	We evaluated the expression of class I HDACs in non-small cell lung cancer (NSCLC) cells and found that HDAC2 was significantly increased in NSCLC cells as compared with the normal bronchial epithelial cell line BEAS-2B.
27635950	Overexpression	Hepatoblastoma	Subsequent expression analysis of primary HB and HB cell lines revealed a general overexpression of HDAC1 and HDAC2, which has been suggested to be predictive for the efficacy of HDAC inhibition.
28560068	Overexpression; copy number gain	Breast Carcinoma	We demonstrated that HDAC2 and SIRT7 were the most commonly amplified/overexpressed, and SIRT3 was most deleted/underexpressed, particularly in aggressive basal-like breast cancer. Overexpression of HDAC2 was significantly correlated with high tumor grade, positive lymph node status, and poor prognosis.

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.496	1.79e-26	46.8	47.5	5.7	Loss
BRCA	Breast invasive carcinoma	1075	0.663	5.13e-137	32.2	51.9	15.9	Neutral
CESC	Cervical and endocervical cancers	292	0.653	8.13e-37	28.4	62.7	8.9	Neutral
COAD	Colon adenocarcinoma	449	0.447	1.95e-23	13.6	71.5	14.9	Neutral
ESCA	Esophageal carcinoma	183	0.645	6.97e-23	26.2	55.7	18	Neutral
GBM	Glioblastoma multiforme	147	0.587	5.24e-15	32.7	64.6	2.7	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.503	2.56e-34	16.9	71.6	11.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.585	1.27e-49	27.4	71	1.5	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.489	1.09e-18	9.7	88.2	2.1	Neutral
LAML	Acute Myeloid Leukemia	166	0.071	0.364	0	100	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.483	2.52e-31	15	83.8	1.2	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.602	3.03e-37	33.8	53.3	12.9	Loss
LUAD	Lung adenocarcinoma	512	0.463	1.32e-28	50.2	43	6.8	Loss
LUSC	Lung squamous cell carcinoma	498	0.593	1.43e-48	25.9	55.4	18.7	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.721	2.18e-49	59	27	14	Loss
PAAD	Pancreatic adenocarcinoma	177	0.574	6.33e-17	46.9	50.8	2.3	Loss
PCPG	Pheochromocytoma and Paraganglioma	162	0.711	3.14e-26	11.7	83.3	4.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.416	6.17e-22	31.2	68	0.8	Neutral
READ	Rectum adenocarcinoma	164	0.591	7.64e-17	19.5	62.2	18.3	Neutral
SARC	Sarcoma	255	0.707	5.61e-40	25.1	54.5	20.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.532	3.35e-28	58.9	35.1	6	Loss
STAD	Stomach adenocarcinoma	413	0.555	1.05e-34	18.6	65.6	15.7	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.192	0.0183	14.7	70.7	14.7	Neutral
THCA	Thyroid carcinoma	497	0.26	4.01e-09	1.4	98.4	0.2	Neutral
THYM	Thymoma	119	0.527	7.72e-10	16	84	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.212	7.43e-07	7.3	79.1	13.6	Neutral

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.205	2.2e-05	17	408	0.002	0.0418	NS/NA
BRCA	Breast invasive carcinoma	-0.262	5.39e-15	83	785	0.004	0.272	NS/NA
CESC	Cervical and endocervical cancers	-0.314	1.97e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.169	0.00253	19	297	0	0.426	NS/NA
ESCA	Esophageal carcinoma	-0.188	0.00871	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.48	6.55e-05	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.244	9.21e-09	20	522	0.001	0.054	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.2	0.000202	24	319	0.002	8.7e-05	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.126	0.0291	23	275	0.003	0.000245	NS/NA
LAML	Acute Myeloid Leukemia	-0.067	0.385	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.108	0.0128	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.27	2.85e-08	41	373	0	0.265	NS/NA
LUAD	Lung adenocarcinoma	-0.082	0.0735	21	456	0.002	0.571	NS/NA
LUSC	Lung squamous cell carcinoma	-0.259	3.59e-07	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.933	0.00075	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.265	0.000294	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.389	4.83e-08	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.413	0	35	498	0.001	0.0467	NS/NA
READ	Rectum adenocarcinoma	-0.302	0.00226	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.3	8.35e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.337	7.16e-14	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.214	3.31e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.259	0.00112	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.107	0.0114	50	509	-0.001	0.719	NS/NA
THYM	Thymoma	-0.207	0.0224	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.143	0.00197	34	431	-0.001	0.512	NS/NA

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	2	Medium
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	1	Low
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	2	Medium
Salivary gland	3	High
Seminal vesicle	2	Medium
Skeletal muscle	3	High
Skin	3	High
Small intestine	2	Medium
Smooth muscle	3	High
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	2	Medium
Tonsil	3	High
Urinary bladder	3	High
Vagina	2	Medium

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.6	NS	24476821
BRCA	Breast invasive carcinoma	521	1.05e-31	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0518	NS	22810696
GBM	Glioblastoma multiforme	157	3.4e-09	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	4.84e-08	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.41	NS	26536169
LGG	Brain Lower Grade Glioma	513	9.06e-10	Significant	26824661
LUAD	Lung adenocarcinoma	230	5.53e-12	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	3.34e-06	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	2.61e-11	Significant	21720365
PRAD	Prostate adenocarcinoma	333	1.92e-19	Significant	26544944
READ	Rectum adenocarcinoma	67	0.11	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.306	NS	26091043
STAD	Stomach adenocarcinoma	277	6.36e-07	Significant	25079317
THCA	Thyroid carcinoma	391	1.34e-06	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0094	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.876	0.518	NS
BRCA	Breast invasive carcinoma	1079	2.104	0.00204	Shorter
CESC	Cervical and endocervical cancers	291	1.521	0.215	NS
COAD	Colon adenocarcinoma	439	0.788	0.378	NS
ESCA	Esophageal carcinoma	184	1.467	0.218	NS
GBM	Glioblastoma multiforme	158	0.679	0.116	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.31	0.179	NS
KIRC	Kidney renal clear cell carcinoma	531	0.828	0.343	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.948	0.108	NS
LAML	Acute Myeloid Leukemia	149	0.911	0.766	NS
LGG	Brain Lower Grade Glioma	511	0.65	0.0742	NS
LIHC	Liver hepatocellular carcinoma	365	2.604	6.91e-05	Shorter
LUAD	Lung adenocarcinoma	502	1.488	0.065	NS
LUSC	Lung squamous cell carcinoma	494	0.725	0.0989	NS
OV	Ovarian serous cystadenocarcinoma	303	1.435	0.0897	NS
PAAD	Pancreatic adenocarcinoma	177	1.031	0.913	NS
PCPG	Pheochromocytoma and Paraganglioma	179	2.622	0.396	NS
PRAD	Prostate adenocarcinoma	497	0.617	0.536	NS
READ	Rectum adenocarcinoma	159	0.776	0.652	NS
SARC	Sarcoma	259	2.188	0.00631	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.03	0.871	NS
STAD	Stomach adenocarcinoma	388	0.995	0.981	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.147	NS
THCA	Thyroid carcinoma	500	0.293	0.061	NS
THYM	Thymoma	119	0.225	0.147	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.893	0.0258	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.114	0.0217	Lower
BRCA	Breast invasive carcinoma	1071	-0.004	0.905	NS
CESC	Cervical and endocervical cancers	167	-0.004	0.961	NS
COAD	Colon adenocarcinoma	445	-0.011	0.825	NS
ESCA	Esophageal carcinoma	162	0.042	0.595	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.078	0.101	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.091	0.0351	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.098	0.114	NS
LIHC	Liver hepatocellular carcinoma	347	0.215	5.61e-05	Higher
LUAD	Lung adenocarcinoma	507	0.109	0.0144	Higher
LUSC	Lung squamous cell carcinoma	497	0.019	0.667	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.116	0.0444	Lower
PAAD	Pancreatic adenocarcinoma	176	-0.034	0.657	NS
READ	Rectum adenocarcinoma	156	0.03	0.713	NS
SKCM	Skin Cutaneous Melanoma	410	-0.096	0.053	NS
STAD	Stomach adenocarcinoma	392	-0.006	0.91	NS
TGCT	Testicular Germ Cell Tumors	81	0.217	0.0519	NS
THCA	Thyroid carcinoma	499	-0.037	0.408	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.088	0.0498	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.103	0.0897	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.088	0.0498	Higher
KIRC	Kidney renal clear cell carcinoma	525	-0.171	8.2e-05	Lower
LGG	Brain Lower Grade Glioma	514	0.078	0.0754	NS
LIHC	Liver hepatocellular carcinoma	366	0.155	0.00296	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.054	0.357	NS
PAAD	Pancreatic adenocarcinoma	176	0.011	0.888	NS
STAD	Stomach adenocarcinoma	406	-0.12	0.0152	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.329	6.32e-15	Higher

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB00227	Lovastatin	Small Molecule Drug
DB00277	Theophylline	Small Molecule Drug
DB00313	Valproic Acid	Small Molecule Drug
DB01223	Aminophylline	Small Molecule Drug
DB01303	Oxtriphylline	Small Molecule Drug
DB02546	Vorinostat	Small Molecule Drug
DB05223	SB939	Small Molecule Drug
DB05651	MGCD-0103	Small Molecule Drug
DB06176	Romidepsin	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug
DB00227	Lovastatin	Small Molecule Drug
DB00277	Theophylline	Small Molecule Drug
DB00313	Valproic Acid	Small Molecule Drug
DB01223	Aminophylline	Small Molecule Drug
DB01303	Oxtriphylline	Small Molecule Drug
DB02546	Vorinostat	Small Molecule Drug
DB05223	SB939	Small Molecule Drug
DB05651	MGCD-0103	Small Molecule Drug
DB06176	Romidepsin	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug

Summary
Symbol	HDAC2
Name	histone deacetylase 2
Aliases	YAF1; HD2; YY1-associated factor 1; transcriptional regulator homolog RPD3
Location	6q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
23420051	Ovarian Carcinoma	partner	HDAC1; HDAC3; HDAC8	Positive correlation	The expression of HDAC2 was positively correlated with HDCA1, HDAC3 and HDAC8, and DNMT1 was positively correlated with DNMT3b.
24448241	Hepatocellular Carcinoma	upstream	mTORC1	positive regulation	Growth factor-induced mTORC1 activates the nuclear translocation of NF-κBp50, where it binds to the intragenic sequences of the HDAC2 gene and promotes its transcription.
23627572	Breast Carcinoma	partner	HER2	Positive correlation	Additionally, a high HDAC2 expression was significantly associated with an overexpression of HER2 (n=203, p=0.005) and the presence of nodal metastasis (n=200, p=0.04).HDAC1 was highly expressed in hormone receptor positive tumors (n=203; p<0.001).
20178884	Endometrial Carcinoma	partner	Ki-67	Positive correlation	The positivity index for histone deacetylase 2 was significantly increased in higher-grade carcinomas (positivity index for grade 3, 124.9 +/- 28.4) compared with grade 1 tumors (86.0 +/- 41.0) and was positively correlated with that for Ki-67.
28262837	Hepatocellular Carcinoma	partner	FBP1	Negative correlation	Low expression of FBP1 correlated with high levels of histone deacetylase 1 (HDAC1) and HDAC2 proteins in HCC patient tissues.
27721407	Pancreatic Carcinoma	partner	TP53	Binding	We further show that HDAC1, HDAC2 and MYC directly bind to the TP53 gene and that MYC recruitment drops upon HDAC inhibitor treatment.
27665474	Non-small Cell Lung Carcinoma	downstream	Fibronectin	Positive regulation	Over expression of HDAC2 increased the protein and mRNA expression of fibronectin (FN), which can accelerate the metastasis of cancer cells.
28560068	Breast Carcinoma	downstream	RAD51	Positive reregulation	Furthermore, HDAC2 expression was positively correlated with a set of DNA-damage response genes, notably RAD51. We revealed a potential mechanism by which HDAC2 regulates RAD51 expression-by indirect mediation through microRNAs, e.g., miR-182.