CR2Cancer

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00850 Histone deacetylase domain

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone acetylation	H2AKac, H2BKac, H3Kac, H4Kac	H2AK, H2BK, H3K, H4K	18285338

> Gene Ontology [ TOP ]
Biological Process	GO:0001503 ossification GO:0001525 angiogenesis GO:0001570 vasculogenesis GO:0001649 osteoblast differentiation GO:0001667 ameboidal-type cell migration GO:0001818 negative regulation of cytokine production GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0006476 protein deacetylation GO:0007043 cell-cell junction assembly GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0016570 histone modification GO:0016575 histone deacetylation GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030335 positive regulation of cell migration GO:0032623 interleukin-2 production GO:0032663 regulation of interleukin-2 production GO:0032703 negative regulation of interleukin-2 production GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0035601 protein deacylation GO:0038061 NIK/NF-kappaB signaling GO:0040017 positive regulation of locomotion GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0045216 cell-cell junction organization GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0048514 blood vessel morphogenesis GO:0051272 positive regulation of cellular component movement GO:0070932 histone H3 deacetylation GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:0098732 macromolecule deacylation GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901223 negative regulation of NIK/NF-kappaB signaling GO:1901342 regulation of vasculature development GO:1902532 negative regulation of intracellular signal transduction GO:1903670 regulation of sprouting angiogenesis GO:1903672 positive regulation of sprouting angiogenesis GO:1904018 positive regulation of vasculature development GO:2000147 positive regulation of cell motility
Molecular Function	GO:0003682 chromatin binding GO:0003714 transcription corepressor activity GO:0004407 histone deacetylase activity GO:0005080 protein kinase C binding GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0019787 ubiquitin-like protein transferase activity GO:0019789 SUMO transferase activity GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0033613 activating transcription factor binding GO:0034979 NAD-dependent protein deacetylase activity GO:0070491 repressing transcription factor binding GO:0071889 14-3-3 protein binding
Cellular Component	GO:0000118 histone deacetylase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-392499: Metabolism of proteins R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-597592: Post-translational protein modification R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-392499: Metabolism of proteins
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-597592: Post-translational protein modification
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4611392	c.1089_1090insC	p.S364fs*33	Insertion - Frameshift	Large_intestine
COSM2068777	c.1640G>A	p.R547H	Substitution - Missense	Stomach
COSM4689703	c.2062G>A	p.A688T	Substitution - Missense	Large_intestine
COSM1734642	c.331G>A	p.G111S	Substitution - Missense	Pancreas
COSM5657466	c.833G>A	p.G278E	Substitution - Missense	Soft_tissue
COSM4689711	c.365C>T	p.T122M	Substitution - Missense	Large_intestine
COSM4207831	c.1104C>A	p.P368P	Substitution - coding silent	Large_intestine
COSM5724125	c.978G>A	p.G326G	Substitution - coding silent	Skin
COSM3461199	c.367G>A	p.E123K	Substitution - Missense	Skin
COSM2068779	c.1635C>T	p.A545A	Substitution - coding silent	Breast
COSM1747002	c.2690G>A	p.C897Y	Substitution - Missense	Urinary_tract
COSM5573930	c.2305_2306insC	p.M769fs*5	Insertion - Frameshift	Prostate
COSM4042131	c.1239C>T	p.G413G	Substitution - coding silent	Stomach
COSM5375225	c.867C>T	p.F289F	Substitution - coding silent	Skin
COSM3792611	c.2809G>A	p.D937N	Substitution - Missense	Urinary_tract
COSM3700284	c.608G>T	p.S203I	Substitution - Missense	Liver
COSM4612869	c.2749_2751delAAA	p.K917delK	Deletion - In frame	Large_intestine
COSM3739685	c.1339C>T	p.Q447*	Substitution - Nonsense	Liver
COSM2068787	c.1256T>G	p.V419G	Substitution - Missense	Pancreas
COSM3461187	c.2842G>A	p.E948K	Substitution - Missense	Skin
COSM5661449	c.1350C>T	p.L450L	Substitution - coding silent	Soft_tissue
COSM2068739	c.2082G>A	p.Q694Q	Substitution - coding silent	Large_intestine
COSM2068772	c.1680C>G	p.L560L	Substitution - coding silent	Large_intestine
COSM5913389	c.1999C>T	p.P667S	Substitution - Missense	Skin
COSM5670795	c.827C>T	p.P276L	Substitution - Missense	Soft_tissue
COSM128142	c.1152C>T	p.H384H	Substitution - coding silent	Upper_aerodigestive_tract
COSM136895	c.2612G>A	p.G871D	Substitution - Missense	Skin
COSM4646982	c.132G>A	p.E44E	Substitution - coding silent	Large_intestine
COSM2068727	c.2304delC	p.M769fs*12	Deletion - Frameshift	Large_intestine
COSM333883	c.1064G>T	p.R355L	Substitution - Missense	Lung
COSM5724125	c.978G>A	p.G326G	Substitution - coding silent	Skin
COSM4650316	c.1385G>A	p.R462Q	Substitution - Missense	Large_intestine
COSM3461193	c.1269C>T	p.G423G	Substitution - coding silent	Skin
COSM5724125	c.978G>A	p.G326G	Substitution - coding silent	Skin
COSM3461189	c.2200G>A	p.D734N	Substitution - Missense	Skin
COSM5888162	c.1234G>A	p.D412N	Substitution - Missense	Upper_aerodigestive_tract
COSM1361826	c.652G>A	p.G218S	Substitution - Missense	Large_intestine
COSM5620942	c.2763G>A	p.E921E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1177566	c.1024G>A	p.E342K	Substitution - Missense	Endometrium
COSM4532884	c.1812G>A	p.L604L	Substitution - coding silent	Skin
COSM2068785	c.1296G>A	p.G432G	Substitution - coding silent	Large_intestine
COSM468399	c.1856G>C	p.G619A	Substitution - Missense	Kidney
COSM939702	c.2704G>A	p.A902T	Substitution - Missense	Endometrium
COSM4916924	c.391A>C	p.S131R	Substitution - Missense	Liver
COSM4650316	c.1385G>A	p.R462Q	Substitution - Missense	Large_intestine
COSM2068793	c.1112C>T	p.P371L	Substitution - Missense	Cervix
COSM5342144	c.983G>A	p.G328E	Substitution - Missense	Large_intestine
COSM117558	c.2422G>A	p.A808T	Substitution - Missense	Ovary
COSM1188479	c.1201C>T	p.R401W	Substitution - Missense	Lung
COSM5679441	c.29C>T	p.P10L	Substitution - Missense	Soft_tissue
COSM291033	c.425G>A	p.S142N	Substitution - Missense	Large_intestine
COSM3954797	c.485G>C	p.R162P	Substitution - Missense	Lung
COSM3461201	c.338C>T	p.P113L	Substitution - Missense	Skin
COSM3772627	c.331G>T	p.G111C	Substitution - Missense	Pancreas
COSM220504	c.2356G>A	p.A786T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5788728	c.1916G>A	p.R639H	Substitution - Missense	Breast
COSM4042121	c.2092G>A	p.A698T	Substitution - Missense	Stomach
COSM4042135	c.674C>T	p.S225L	Substitution - Missense	Stomach
COSM4042129	c.1746T>C	p.S582S	Substitution - coding silent	Stomach
COSM1562090	c.1027C>T	p.R343W	Substitution - Missense	Large_intestine
COSM3384384	c.1786C>T	p.R596C	Substitution - Missense	Pancreas
COSM2068809	c.552delC	p.S185fs*138	Deletion - Frameshift	Large_intestine
COSM4042137	c.297G>A	p.A99A	Substitution - coding silent	Stomach
COSM3954795	c.1702C>G	p.R568G	Substitution - Missense	Lung
COSM220440	c.464C>T	p.S155F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4689705	c.1130G>A	p.R377H	Substitution - Missense	Large_intestine
COSM4754576	c.563G>A	p.R188Q	Substitution - Missense	Stomach
COSM1705517	c.383C>T	p.S128F	Substitution - Missense	Skin
COSM1361823	c.2343C>T	p.V781V	Substitution - coding silent	Large_intestine
COSM1638214	c.2105T>G	p.L702R	Substitution - Missense	Bone
COSM1741245	c.784G>T	p.A262S	Substitution - Missense	Urinary_tract
COSM220440	c.464C>T	p.S155F	Substitution - Missense	Skin
COSM5724125	c.978G>A	p.G326G	Substitution - coding silent	Skin
COSM1606166	c.1187A>G	p.E396G	Substitution - Missense	Liver
COSM4409784	c.328C>A	p.P110T	Substitution - Missense	Oesophagus
COSM1361822	c.2476C>A	p.Q826K	Substitution - Missense	Large_intestine
COSM3461191	c.2191C>T	p.R731C	Substitution - Missense	Skin
COSM3812093	c.531C>G	p.L177L	Substitution - coding silent	Breast
COSM1209393	c.188A>G	p.E63G	Substitution - Missense	Large_intestine
COSM399663	c.1023C>T	p.T341T	Substitution - coding silent	Lung
COSM4042123	c.1993C>T	p.R665W	Substitution - Missense	Stomach
COSM3704169	c.694C>T	p.R232W	Substitution - Missense	Liver
COSM5375227	c.495C>T	p.P165P	Substitution - coding silent	Skin
COSM364328	c.1639C>T	p.R547C	Substitution - Missense	Lung
COSM4689709	c.485G>A	p.R162H	Substitution - Missense	Large_intestine
COSM3780987	c.23G>A	p.R8Q	Substitution - Missense	Pancreas
COSM1361825	c.1700T>A	p.L567H	Substitution - Missense	Large_intestine
COSM3461195	c.1128C>T	p.P376P	Substitution - coding silent	Skin
COSM5774711	c.2590-7T>C	p.?	Unknown	Breast
COSM4993628	c.428_429insC	p.E146fs*11	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1606166	c.1187A>G	p.E396G	Substitution - Missense	Liver
COSM4042127	c.1965T>C	p.R655R	Substitution - coding silent	Stomach
COSM4689713	c.230G>A	p.R77Q	Substitution - Missense	Large_intestine
COSM244871	c.389T>G	p.L130R	Substitution - Missense	Prostate
COSM4495121	c.329C>T	p.P110L	Substitution - Missense	Skin
COSM3704169	c.694C>T	p.R232W	Substitution - Missense	Liver
COSM2068727	c.2304delC	p.M769fs*12	Deletion - Frameshift	Stomach
COSM4976217	c.1791C>T	p.L597L	Substitution - coding silent	Oesophagus
COSM4689707	c.1098C>T	p.T366T	Substitution - coding silent	Large_intestine
COSM330872	c.1660C>T	p.R554W	Substitution - Missense	Lung
COSM4776962	c.829C>T	p.R277W	Substitution - Missense	Breast
COSM939708	c.141+7_141+8insG	p.?	Unknown	Endometrium
COSM5030166	c.1446C>T	p.S482S	Substitution - coding silent	Bone
COSM3461197	c.404C>T	p.P135L	Substitution - Missense	Skin
COSM355009	c.1074A>C	p.S358S	Substitution - coding silent	Lung
COSM4042133	c.975C>T	p.P325P	Substitution - coding silent	Stomach
COSM2068725	c.2304_2305insC	p.M769fs*5	Insertion - Frameshift	Large_intestine
COSM939707	c.385A>G	p.M129V	Substitution - Missense	Endometrium
COSM1719038	c.413C>T	p.P138L	Substitution - Missense	Skin
COSM1209391	c.269C>T	p.A90V	Substitution - Missense	Large_intestine
COSM5021754	c.543T>G	p.S181R	Substitution - Missense	Bone
COSM5453154	c.680C>T	p.A227V	Substitution - Missense	Large_intestine
COSM1209392	c.2435G>T	p.G812V	Substitution - Missense	Large_intestine
COSM4844121	c.2650C>T	p.L884L	Substitution - coding silent	Cervix
COSM6000237	c.2816C>T	p.P939L	Substitution - Missense	Prostate
COSM3461195	c.1128C>T	p.P376P	Substitution - coding silent	Skin
COSM4689701	c.2421G>A	p.P807P	Substitution - coding silent	Large_intestine
COSM6000237	c.2816C>T	p.P939L	Substitution - Missense	Prostate
COSM6000432	c.1570T>G	p.Y524D	Substitution - Missense	Prostate
COSM4973741	c.559C>T	p.R187W	Substitution - Missense	Oesophagus
COSM4471407	c.1601C>T	p.S534F	Substitution - Missense	Skin
COSM4767332	c.1769G>A	p.G590D	Substitution - Missense	Stomach
COSM4042125	c.1984G>A	p.A662T	Substitution - Missense	Stomach
COSM339311	c.1005C>G	p.A335A	Substitution - coding silent	Lung
COSM939703	c.2683T>C	p.W895R	Substitution - Missense	Endometrium
COSM939705	c.1945G>A	p.A649T	Substitution - Missense	Endometrium
COSM5684502	c.1277A>C	p.H426P	Substitution - Missense	Soft_tissue
COSM1169340	c.497_498insA	p.K167fs*35	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM1628624	c.2238+10T>C	p.?	Unknown	Liver
COSM5051598	c.2082G>T	p.Q694H	Substitution - Missense	Stomach
COSM5435893	c.1798G>A	p.D600N	Substitution - Missense	Oesophagus
COSM1177566	c.1024G>A	p.E342K	Substitution - Missense	Large_intestine
COSM1579804	c.2698C>T	p.R900C	Substitution - Missense	Central_nervous_system
COSM3812091	c.2083C>A	p.Q695K	Substitution - Missense	Breast
COSM4042139	c.159G>A	p.P53P	Substitution - coding silent	Stomach
COSM4564670	c.1224_1225CC>TT	p.(=)	Unknown	Skin
COSM2068706	c.2781G>A	p.A927A	Substitution - coding silent	Large_intestine
COSM2068727	c.2304delC	p.M769fs*12	Deletion - Frameshift	Large_intestine
COSM939704	c.1963C>T	p.R655C	Substitution - Missense	Endometrium
COSM693843	c.1626G>C	p.P542P	Substitution - coding silent	Lung
COSM5626605	c.1339C>G	p.Q447E	Substitution - Missense	Oesophagus
COSM6014909	c.662C>T	p.P221L	Substitution - Missense	Skin
COSM4042118	c.2626C>T	p.P876S	Substitution - Missense	Stomach
COSM1730166	c.937G>T	p.D313Y	Substitution - Missense	Liver
COSM3704169	c.694C>T	p.R232W	Substitution - Missense	Biliary_tract
COSM3871681	c.2228C>T	p.A743V	Substitution - Missense	Skin
COSM4689698	c.2644C>T	p.R882C	Substitution - Missense	Large_intestine
COSM6000432	c.1570T>G	p.Y524D	Substitution - Missense	Prostate
COSM4152829	c.590C>T	p.S197F	Substitution - Missense	Kidney
COSM33038	c.127G>A	p.V43M	Substitution - Missense	Breast
COSM4562896	c.831G>A	p.R277R	Substitution - coding silent	Skin
COSM4645132	c.1661G>T	p.R554L	Substitution - Missense	Large_intestine
COSM2068743	c.2049C>T	p.N683N	Substitution - coding silent	Central_nervous_system
COSM5549138	c.545C>T	p.A182V	Substitution - Missense	Prostate
COSM381882	c.1028G>T	p.R343L	Substitution - Missense	Lung
COSM1299398	c.315C>G	p.V105V	Substitution - coding silent	Urinary_tract
COSM23308	c.2550C>G	p.D850E	Substitution - Missense	Lung
COSM6000432	c.1570T>G	p.Y524D	Substitution - Missense	Prostate
COSM6000237	c.2816C>T	p.P939L	Substitution - Missense	Prostate
COSM4656857	c.1826C>A	p.A609E	Substitution - Missense	Large_intestine
COSM5970710	c.957C>A	p.A319A	Substitution - coding silent	Upper_aerodigestive_tract
COSM4494447	c.315C>T	p.V105V	Substitution - coding silent	Skin
COSM1686672	c.233-1G>A	p.?	Unknown	Skin
COSM1747002	c.2690G>A	p.C897Y	Substitution - Missense	Urinary_tract
COSM548344	c.330C>A	p.P110P	Substitution - coding silent	Soft_tissue
COSM325481	c.1129C>T	p.R377C	Substitution - Missense	Lung
COSM939706	c.1830G>T	p.Q610H	Substitution - Missense	Endometrium
COSM5038687	c.2756_2758delAAG	p.E919delE	Deletion - In frame	Liver
COSM371722	c.1937C>G	p.T646S	Substitution - Missense	Lung
COSM1719038	c.413C>T	p.P138L	Substitution - Missense	Skin
COSM4636594	c.79C>T	p.R27C	Substitution - Missense	Large_intestine
COSM4627098	c.122G>A	p.R41H	Substitution - Missense	Large_intestine
COSM5051600	c.1737G>A	p.S579S	Substitution - coding silent	Stomach
COSM6000432	c.1570T>G	p.Y524D	Substitution - Missense	Prostate
COSM1628625	c.494C>A	p.P165H	Substitution - Missense	Liver
COSM5470020	c.156G>A	p.T52T	Substitution - coding silent	Large_intestine

> Text Mining based Variations [ TOP ]
There is no record for HDAC7.

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8WUI4	155	S	Phosphoserine	MARK2, MARK3 and PKD/PRKD1	Yes	p.S155F (cancer: SKCM)
Q8WUI4	181	S	Phosphoserine	PKD/PRKD2	No	None detected
Q8WUI4	283	S	Phosphoserine	-	No	None detected
Q8WUI4	286	T	Phosphothreonine	-	No	None detected
Q8WUI4	358	S	Phosphoserine	PKD/PRKD1	No	None detected
Q8WUI4	364	S	Phosphoserine	-	Yes	p.S364fs (cancer: LUAD, STAD)
Q8WUI4	405	S	Phosphoserine	-	No	None detected
Q8WUI4	486	S	Phosphoserine	-	No	None detected
Q8WUI4	487	S	Phosphoserine	-	No	None detected
Q8WUI4	507	S	Phosphoserine	-	No	None detected
Q8WUI4	595	S	Phosphoserine	-	No	None detected

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.786	6.854	0.163	0.304	NS
BRCA	Breast invasive carcinoma	112	1100	6.543	6.404	-0.155	0.00349	NS
CESC	Cervical and endocervical cancers	3	306	7.399	6.631	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.305	5.894	0.525	6.4e-10	NS
ESCA	Esophageal carcinoma	11	185	6.086	6.205	0.075	0.711	NS
GBM	Glioblastoma multiforme	5	166	5.118	5.837	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.065	6.127	0.099	0.212	NS
KIRC	Kidney renal clear cell carcinoma	72	534	6.035	6.591	0.493	7.23e-12	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	6.441	6.58	0.167	0.14	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.006	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.386	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.827	4.505	0.614	5.24e-06	Over
LUAD	Lung adenocarcinoma	59	517	7.041	6.58	-0.414	6.03e-08	NS
LUSC	Lung squamous cell carcinoma	51	501	7.021	6.208	-0.813	2.3e-19	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.778	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.227	6.913	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	7.304	6.059	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.183	6.172	0.006	0.906	NS
READ	Rectum adenocarcinoma	10	167	5.522	5.876	0.45	0.00242	NS
SARC	Sarcoma	2	263	6.362	7.078	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.211	6.001	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	6.252	6.361	0.218	0.0386	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.161	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.445	6.919	0.461	8e-22	NS
THYM	Thymoma	2	120	9.042	8.238	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	7.213	6.851	-0.283	0.00866	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6
Autonomic ganglia	CHP212	6.5
Autonomic ganglia	IMR32	6.2
Autonomic ganglia	KELLY	6.4
Autonomic ganglia	KPNRTBM1	6.7
Autonomic ganglia	KPNSI9S	6.3
Autonomic ganglia	KPNYN	6.2
Autonomic ganglia	MHHNB11	7
Autonomic ganglia	NB1	6.4
Autonomic ganglia	NH6	5.9
Autonomic ganglia	SHSY5Y	6
Autonomic ganglia	SIMA	6.2
Autonomic ganglia	SKNAS	6.4
Autonomic ganglia	SKNBE2	6.5
Autonomic ganglia	SKNDZ	5.5
Autonomic ganglia	SKNFI	5.6
Autonomic ganglia	SKNSH	5.6
Biliary tract	HUCCT1	6.8
Biliary tract	HUH28	6.8
Biliary tract	SNU1079	6.7
Biliary tract	SNU1196	6.4
Biliary tract	SNU245	5.8
Biliary tract	SNU308	6.3
Biliary tract	SNU478	6.9
Bone	143B	6.6
Bone	A673	5.7
Bone	CADOES1	6.1
Bone	CAL78	5.8
Bone	G292CLONEA141B1	6.2
Bone	HOS	6.5
Bone	HS706T	6.1
Bone	HS737T	6.3
Bone	HS819T	6.6
Bone	HS821T	6.5
Bone	HS822T	6.2
Bone	HS863T	6.4
Bone	HS870T	6.7
Bone	HS888T	6.5
Bone	MG63	6.7
Bone	MHHES1	7.3
Bone	OUMS27	6.5
Bone	RDES	5.9
Bone	SJSA1	6.3
Bone	SKES1	5.7
Bone	SKNMC	5.8
Bone	SW1353	6.5
Bone	T173	6.5
Bone	TC71	4.9
Bone	U2OS	6.8
Breast	AU565	5.6
Breast	BT20	6.4
Breast	BT474	6.3
Breast	BT483	6.7
Breast	BT549	6.2
Breast	CAL120	6.2
Breast	CAL148	6.4
Breast	CAL51	7.5
Breast	CAL851	5.9
Breast	CAMA1	5.6
Breast	DU4475	6
Breast	EFM192A	6.1
Breast	EFM19	6.5
Breast	EVSAT	5.4
Breast	HCC1143	6.3
Breast	HCC1187	6.1
Breast	HCC1395	6.1
Breast	HCC1419	5.8
Breast	HCC1428	5.9
Breast	HCC1500	5.7
Breast	HCC1569	6.2
Breast	HCC1599	6
Breast	HCC1806	6.9
Breast	HCC1937	6.2
Breast	HCC1954	5.8
Breast	HCC202	6.6
Breast	HCC2157	6.2
Breast	HCC2218	5.8
Breast	HCC38	6
Breast	HCC70	6.6
Breast	HDQP1	7
Breast	HMC18	6.5
Breast	HS274T	6.8
Breast	HS281T	7
Breast	HS343T	6.4
Breast	HS578T	6.3
Breast	HS606T	6.7
Breast	HS739T	6.4
Breast	HS742T	6.6
Breast	JIMT1	6.8
Breast	KPL1	6.3
Breast	MCF7	5.7
Breast	MDAMB134VI	6.4
Breast	MDAMB157	6.2
Breast	MDAMB175VII	6.3
Breast	MDAMB231	6.2
Breast	MDAMB361	5.9
Breast	MDAMB415	6.5
Breast	MDAMB436	5.9
Breast	MDAMB453	6.2
Breast	MDAMB468	6.4
Breast	SKBR3	5.7
Breast	T47D	5.8
Breast	UACC812	7.1
Breast	UACC893	6.7
Breast	YMB1	5.9
Breast	ZR751	5.8
Breast	ZR7530	6.8
Central nervous system	1321N1	6.2
Central nervous system	42MGBA	6.3
Central nervous system	8MGBA	5.6
Central nervous system	A172	6.2
Central nervous system	AM38	6.3
Central nervous system	BECKER	6.1
Central nervous system	CAS1	6.1
Central nervous system	CCFSTTG1	6.5
Central nervous system	D283MED	6
Central nervous system	D341MED	6.1
Central nervous system	DAOY	6.3
Central nervous system	DBTRG05MG	6
Central nervous system	DKMG	5.8
Central nervous system	GAMG	5.6
Central nervous system	GB1	7.4
Central nervous system	GI1	6.2
Central nervous system	GMS10	6.4
Central nervous system	GOS3	6.3
Central nervous system	H4	6.1
Central nervous system	HS683	6
Central nervous system	KALS1	6.5
Central nervous system	KG1C	6.6
Central nervous system	KNS42	5.9
Central nervous system	KNS60	6.7
Central nervous system	KNS81	6.6
Central nervous system	KS1	5.5
Central nervous system	LN18	6.4
Central nervous system	LN229	6
Central nervous system	M059K	6.1
Central nervous system	MOGGCCM	6.5
Central nervous system	MOGGUVW	6.4
Central nervous system	NMCG1	6.3
Central nervous system	ONS76	6.2
Central nervous system	SF126	6.2
Central nervous system	SF295	6.3
Central nervous system	SNB19	5.8
Central nervous system	SNU1105	6.1
Central nervous system	SNU201	6.3
Central nervous system	SNU466	6.1
Central nervous system	SNU489	6.5
Central nervous system	SNU626	6.5
Central nervous system	SNU738	6.1
Central nervous system	SW1088	6.3
Central nervous system	SW1783	6.1
Central nervous system	T98G	6.2
Central nervous system	TM31	6.4
Central nervous system	U118MG	6.9
Central nervous system	U138MG	6.8
Central nervous system	U251MG	5.9
Central nervous system	U87MG	6.3
Central nervous system	YH13	6.1
Central nervous system	YKG1	6.1
Endometrium	AN3CA	6.8
Endometrium	COLO684	5.9
Endometrium	EFE184	7.4
Endometrium	EN	6.2
Endometrium	ESS1	6.4
Endometrium	HEC108	6.7
Endometrium	HEC151	5.4
Endometrium	HEC1A	7.1
Endometrium	HEC1B	6.6
Endometrium	HEC251	7
Endometrium	HEC265	7.3
Endometrium	HEC50B	6.1
Endometrium	HEC59	6.5
Endometrium	HEC6	6
Endometrium	ISHIKAWAHERAKLIO02ER	6
Endometrium	JHUEM1	6.6
Endometrium	JHUEM2	6.3
Endometrium	JHUEM3	7.2
Endometrium	KLE	7.9
Endometrium	MFE280	6.3
Endometrium	MFE296	6.2
Endometrium	MFE319	7.3
Endometrium	RL952	6.1
Endometrium	SNGM	6.9
Endometrium	SNU1077	7
Endometrium	SNU685	7.1
Endometrium	TEN	7.5
Haematopoietic and lymphoid	697	7.1
Haematopoietic and lymphoid	A3KAW	6.3
Haematopoietic and lymphoid	A4FUK	6.7
Haematopoietic and lymphoid	ALLSIL	7.2
Haematopoietic and lymphoid	AML193	6
Haematopoietic and lymphoid	AMO1	6.9
Haematopoietic and lymphoid	BCP1	6.1
Haematopoietic and lymphoid	BDCM	5.6
Haematopoietic and lymphoid	BL41	7.3
Haematopoietic and lymphoid	BL70	6.9
Haematopoietic and lymphoid	BV173	7.7
Haematopoietic and lymphoid	CA46	6.9
Haematopoietic and lymphoid	CI1	6.2
Haematopoietic and lymphoid	CMK115	7.9
Haematopoietic and lymphoid	CMK86	8.2
Haematopoietic and lymphoid	CMK	7.6
Haematopoietic and lymphoid	CMLT1	6.7
Haematopoietic and lymphoid	COLO775	7.8
Haematopoietic and lymphoid	DAUDI	7.9
Haematopoietic and lymphoid	DB	6.5
Haematopoietic and lymphoid	DEL	6.9
Haematopoietic and lymphoid	DND41	6.8
Haematopoietic and lymphoid	DOHH2	7.6
Haematopoietic and lymphoid	EB1	6.6
Haematopoietic and lymphoid	EB2	6.8
Haematopoietic and lymphoid	EHEB	5.2
Haematopoietic and lymphoid	EJM	6.2
Haematopoietic and lymphoid	EM2	5.8
Haematopoietic and lymphoid	EOL1	6.3
Haematopoietic and lymphoid	F36P	8.1
Haematopoietic and lymphoid	GA10	6.6
Haematopoietic and lymphoid	GDM1	6.9
Haematopoietic and lymphoid	GRANTA519	5.5
Haematopoietic and lymphoid	HDLM2	6.1
Haematopoietic and lymphoid	HDMYZ	5.9
Haematopoietic and lymphoid	HEL9217	7
Haematopoietic and lymphoid	HEL	7
Haematopoietic and lymphoid	HH	6.5
Haematopoietic and lymphoid	HL60	6.3
Haematopoietic and lymphoid	HPBALL	7.9
Haematopoietic and lymphoid	HS604T	6.8
Haematopoietic and lymphoid	HS611T	7
Haematopoietic and lymphoid	HS616T	6.7
Haematopoietic and lymphoid	HS751T	5.5
Haematopoietic and lymphoid	HT	7
Haematopoietic and lymphoid	HTK	6.4
Haematopoietic and lymphoid	HUNS1	4.9
Haematopoietic and lymphoid	HUT102	6.6
Haematopoietic and lymphoid	HUT78	6.2
Haematopoietic and lymphoid	JEKO1	7.2
Haematopoietic and lymphoid	JK1	7.6
Haematopoietic and lymphoid	JM1	6.7
Haematopoietic and lymphoid	JURKAT	7
Haematopoietic and lymphoid	JURLMK1	8.5
Haematopoietic and lymphoid	JVM2	5.3
Haematopoietic and lymphoid	JVM3	5.5
Haematopoietic and lymphoid	K562	6.8
Haematopoietic and lymphoid	KARPAS299	5.8
Haematopoietic and lymphoid	KARPAS422	6.8
Haematopoietic and lymphoid	KARPAS620	6.9
Haematopoietic and lymphoid	KASUMI1	5.8
Haematopoietic and lymphoid	KASUMI2	6.7
Haematopoietic and lymphoid	KASUMI6	6.2
Haematopoietic and lymphoid	KCL22	5.7
Haematopoietic and lymphoid	KE37	7.7
Haematopoietic and lymphoid	KE97	5
Haematopoietic and lymphoid	KG1	6.7
Haematopoietic and lymphoid	KHM1B	6.5
Haematopoietic and lymphoid	KIJK	5.7
Haematopoietic and lymphoid	KMH2	7.2
Haematopoietic and lymphoid	KMM1	6.9
Haematopoietic and lymphoid	KMS11	6.9
Haematopoietic and lymphoid	KMS12BM	6.4
Haematopoietic and lymphoid	KMS18	5.7
Haematopoietic and lymphoid	KMS20	7.1
Haematopoietic and lymphoid	KMS21BM	6.8
Haematopoietic and lymphoid	KMS26	6
Haematopoietic and lymphoid	KMS27	6.7
Haematopoietic and lymphoid	KMS28BM	7
Haematopoietic and lymphoid	KMS34	7.1
Haematopoietic and lymphoid	KO52	6.3
Haematopoietic and lymphoid	KOPN8	6.9
Haematopoietic and lymphoid	KU812	8.1
Haematopoietic and lymphoid	KYO1	7.4
Haematopoietic and lymphoid	L1236	6.1
Haematopoietic and lymphoid	L363	6.4
Haematopoietic and lymphoid	L428	6.5
Haematopoietic and lymphoid	L540	6.4
Haematopoietic and lymphoid	LAMA84	7.7
Haematopoietic and lymphoid	LOUCY	6.7
Haematopoietic and lymphoid	LP1	6.8
Haematopoietic and lymphoid	M07E	7.5
Haematopoietic and lymphoid	MC116	6.4
Haematopoietic and lymphoid	ME1	7.1
Haematopoietic and lymphoid	MEC1	5.3
Haematopoietic and lymphoid	MEC2	6.1
Haematopoietic and lymphoid	MEG01	7.8
Haematopoietic and lymphoid	MHHCALL2	6.8
Haematopoietic and lymphoid	MHHCALL3	7
Haematopoietic and lymphoid	MHHCALL4	7.2
Haematopoietic and lymphoid	MINO	6.3
Haematopoietic and lymphoid	MJ	6.4
Haematopoietic and lymphoid	MM1S	7
Haematopoietic and lymphoid	MOLM13	6.2
Haematopoietic and lymphoid	MOLM16	8.3
Haematopoietic and lymphoid	MOLM6	6.2
Haematopoietic and lymphoid	MOLP2	6.6
Haematopoietic and lymphoid	MOLP8	6.3
Haematopoietic and lymphoid	MOLT13	7.1
Haematopoietic and lymphoid	MOLT16	6.5
Haematopoietic and lymphoid	MOLT4	6.7
Haematopoietic and lymphoid	MONOMAC1	6.1
Haematopoietic and lymphoid	MONOMAC6	6.1
Haematopoietic and lymphoid	MOTN1	7.9
Haematopoietic and lymphoid	MUTZ5	7.6
Haematopoietic and lymphoid	MV411	6.7
Haematopoietic and lymphoid	NALM19	6.5
Haematopoietic and lymphoid	NALM1	7.1
Haematopoietic and lymphoid	NALM6	7.3
Haematopoietic and lymphoid	NAMALWA	6.6
Haematopoietic and lymphoid	NB4	6.5
Haematopoietic and lymphoid	NCIH929	6.6
Haematopoietic and lymphoid	NCO2	7.5
Haematopoietic and lymphoid	NOMO1	6.4
Haematopoietic and lymphoid	NUDHL1	7.9
Haematopoietic and lymphoid	NUDUL1	7
Haematopoietic and lymphoid	OCIAML2	6.6
Haematopoietic and lymphoid	OCIAML3	6
Haematopoietic and lymphoid	OCIAML5	6.2
Haematopoietic and lymphoid	OCILY10	6.8
Haematopoietic and lymphoid	OCILY19	7.9
Haematopoietic and lymphoid	OCILY3	6.1
Haematopoietic and lymphoid	OCIM1	7.5
Haematopoietic and lymphoid	OPM2	6.9
Haematopoietic and lymphoid	P12ICHIKAWA	6.8
Haematopoietic and lymphoid	P31FUJ	5.6
Haematopoietic and lymphoid	P3HR1	7
Haematopoietic and lymphoid	PCM6	7.2
Haematopoietic and lymphoid	PEER	7.2
Haematopoietic and lymphoid	PF382	7.8
Haematopoietic and lymphoid	PFEIFFER	8.2
Haematopoietic and lymphoid	PL21	6
Haematopoietic and lymphoid	RAJI	6.9
Haematopoietic and lymphoid	RCHACV	6.8
Haematopoietic and lymphoid	REC1	6.9
Haematopoietic and lymphoid	REH	6.9
Haematopoietic and lymphoid	RI1	7.3
Haematopoietic and lymphoid	RL	7.3
Haematopoietic and lymphoid	RPMI8226	6.3
Haematopoietic and lymphoid	RPMI8402	6.7
Haematopoietic and lymphoid	RS411	6.1
Haematopoietic and lymphoid	SEM	6
Haematopoietic and lymphoid	SET2	8.8
Haematopoietic and lymphoid	SIGM5	6.3
Haematopoietic and lymphoid	SKM1	5.7
Haematopoietic and lymphoid	SKMM2	6.5
Haematopoietic and lymphoid	SR786	6.1
Haematopoietic and lymphoid	ST486	6
Haematopoietic and lymphoid	SUDHL10	7.3
Haematopoietic and lymphoid	SUDHL1	6.1
Haematopoietic and lymphoid	SUDHL4	7.7
Haematopoietic and lymphoid	SUDHL5	8.3
Haematopoietic and lymphoid	SUDHL6	7
Haematopoietic and lymphoid	SUDHL8	6.9
Haematopoietic and lymphoid	SUPB15	7.1
Haematopoietic and lymphoid	SUPHD1	5.9
Haematopoietic and lymphoid	SUPM2	5.4
Haematopoietic and lymphoid	SUPT11	5.5
Haematopoietic and lymphoid	SUPT1	7.2
Haematopoietic and lymphoid	TALL1	7.4
Haematopoietic and lymphoid	TF1	9.5
Haematopoietic and lymphoid	THP1	5.3
Haematopoietic and lymphoid	TO175T	7.2
Haematopoietic and lymphoid	TOLEDO	6.5
Haematopoietic and lymphoid	U266B1	7.1
Haematopoietic and lymphoid	U937	6
Haematopoietic and lymphoid	UT7	8.6
Haematopoietic and lymphoid	WSUDLCL2	7.3
Kidney	769P	6.2
Kidney	786O	6.6
Kidney	A498	6.7
Kidney	A704	5.8
Kidney	ACHN	6.6
Kidney	BFTC909	7.1
Kidney	CAKI1	6.4
Kidney	CAKI2	5.7
Kidney	CAL54	6.1
Kidney	KMRC1	6.4
Kidney	KMRC20	6.4
Kidney	KMRC2	6.8
Kidney	KMRC3	6.3
Kidney	OSRC2	6.9
Kidney	RCC10RGB	6.5
Kidney	SNU1272	7
Kidney	SNU349	7.3
Kidney	TUHR10TKB	6.7
Kidney	TUHR14TKB	6.5
Kidney	TUHR4TKB	6.5
Kidney	VMRCRCW	6
Kidney	VMRCRCZ	6.5
Large intestine	C2BBE1	6.6
Large intestine	CCK81	6.5
Large intestine	CL11	6.4
Large intestine	CL14	6.4
Large intestine	CL34	5.6
Large intestine	CL40	6.6
Large intestine	COLO205	5.4
Large intestine	COLO320	5.5
Large intestine	COLO678	7.4
Large intestine	CW2	6.1
Large intestine	DLD1	6
Large intestine	GP2D	5.4
Large intestine	HCC56	6.3
Large intestine	HCT116	5.7
Large intestine	HCT15	6.3
Large intestine	HS675T	6
Large intestine	HS698T	6.9
Large intestine	HT115	6.6
Large intestine	HT29	6.7
Large intestine	HT55	5.8
Large intestine	KM12	5.7
Large intestine	LOVO	6
Large intestine	LS1034	5.8
Large intestine	LS123	6.5
Large intestine	LS180	6.2
Large intestine	LS411N	5.9
Large intestine	LS513	5.7
Large intestine	MDST8	5.8
Large intestine	NCIH508	6.4
Large intestine	NCIH716	5.7
Large intestine	NCIH747	6.7
Large intestine	OUMS23	6.8
Large intestine	RCM1	6.3
Large intestine	RKO	6.1
Large intestine	SKCO1	6.2
Large intestine	SNU1040	5.7
Large intestine	SNU1197	6.8
Large intestine	SNU175	5.6
Large intestine	SNU283	5.6
Large intestine	SNU407	6.4
Large intestine	SNU503	6
Large intestine	SNU61	6.4
Large intestine	SNU81	6.2
Large intestine	SNUC1	5.9
Large intestine	SNUC2A	6.4
Large intestine	SNUC4	6.2
Large intestine	SNUC5	7
Large intestine	SW1116	6.3
Large intestine	SW1417	6.1
Large intestine	SW1463	6.1
Large intestine	SW403	6.4
Large intestine	SW480	6.2
Large intestine	SW48	5.9
Large intestine	SW620	6.2
Large intestine	SW837	5.5
Large intestine	SW948	6
Large intestine	T84	7.1
Liver	ALEXANDERCELLS	5.8
Liver	C3A	6.4
Liver	HEP3B217	6.4
Liver	HEPG2	5.4
Liver	HLE	5.9
Liver	HLF	6
Liver	HUH1	6.3
Liver	HUH6	7.1
Liver	HUH7	6.2
Liver	JHH1	6.9
Liver	JHH2	6.5
Liver	JHH4	6.5
Liver	JHH5	6.2
Liver	JHH6	5.4
Liver	JHH7	5.7
Liver	LI7	6.5
Liver	PLCPRF5	6.6
Liver	SKHEP1	5.6
Liver	SNU182	6.2
Liver	SNU387	6.7
Liver	SNU398	5.7
Liver	SNU423	6
Liver	SNU449	6.2
Liver	SNU475	6.3
Liver	SNU761	6.7
Liver	SNU878	6
Liver	SNU886	7
Lung	A549	6.2
Lung	ABC1	6.9
Lung	BEN	6.1
Lung	CAL12T	6.1
Lung	CALU1	7
Lung	CALU3	6.1
Lung	CALU6	5.6
Lung	CHAGOK1	6.1
Lung	COLO668	5.6
Lung	COLO699	6
Lung	CORL105	6.1
Lung	CORL23	6.6
Lung	CORL24	5
Lung	CORL279	5.4
Lung	CORL311	5.7
Lung	CORL47	5.1
Lung	CORL51	5.4
Lung	CORL88	5.1
Lung	CORL95	5
Lung	CPCN	5.3
Lung	DMS114	5.7
Lung	DMS153	5.9
Lung	DMS273	5.1
Lung	DMS454	5
Lung	DMS53	5.8
Lung	DMS79	5.8
Lung	DV90	5.9
Lung	EBC1	6.5
Lung	EPLC272H	6.2
Lung	HARA	5.9
Lung	HCC1171	6.9
Lung	HCC1195	6.6
Lung	HCC15	6.4
Lung	HCC2279	6.2
Lung	HCC2935	6.5
Lung	HCC33	4.9
Lung	HCC366	5.5
Lung	HCC4006	6.4
Lung	HCC44	6.3
Lung	HCC78	7.4
Lung	HCC827	6.8
Lung	HCC95	5.5
Lung	HLC1	5.8
Lung	HLFA	6.3
Lung	HS229T	6.4
Lung	HS618T	6.3
Lung	IALM	6.7
Lung	KNS62	6.5
Lung	LC1F	5.8
Lung	LC1SQSF	5.2
Lung	LCLC103H	6.5
Lung	LCLC97TM1	6.7
Lung	LK2	5.9
Lung	LOUNH91	6.6
Lung	LU65	5.9
Lung	LU99	6.6
Lung	LUDLU1	6.2
Lung	LXF289	6.4
Lung	MORCPR	6.9
Lung	NCIH1048	6.3
Lung	NCIH1092	4.5
Lung	NCIH1105	5.4
Lung	NCIH1155	5.6
Lung	NCIH1184	5.4
Lung	NCIH1299	6.9
Lung	NCIH1339	5.7
Lung	NCIH1341	5.7
Lung	NCIH1355	6.5
Lung	NCIH1373	7.2
Lung	NCIH1385	6
Lung	NCIH1395	6.7
Lung	NCIH1435	6.6
Lung	NCIH1436	5.2
Lung	NCIH1437	6.8
Lung	NCIH146	5
Lung	NCIH1563	6.1
Lung	NCIH1568	5.3
Lung	NCIH1573	6
Lung	NCIH1581	6.1
Lung	NCIH1618	6
Lung	NCIH1623	7
Lung	NCIH1648	6.9
Lung	NCIH1650	6.5
Lung	NCIH1651	5.9
Lung	NCIH1666	6.7
Lung	NCIH1693	7.2
Lung	NCIH1694	5.9
Lung	NCIH1703	5.9
Lung	NCIH1734	6.1
Lung	NCIH1755	5.9
Lung	NCIH1781	5.6
Lung	NCIH1792	5.8
Lung	NCIH1793	6.2
Lung	NCIH1836	5.6
Lung	NCIH1838	6.2
Lung	NCIH1869	6.2
Lung	NCIH1876	5.5
Lung	NCIH1915	6.2
Lung	NCIH1930	5.3
Lung	NCIH1944	5.1
Lung	NCIH1963	5.3
Lung	NCIH196	5.9
Lung	NCIH1975	6
Lung	NCIH2009	6.4
Lung	NCIH2023	6.5
Lung	NCIH2029	5.5
Lung	NCIH2030	6.3
Lung	NCIH2066	5.3
Lung	NCIH2081	5.2
Lung	NCIH2085	6.7
Lung	NCIH2087	6.3
Lung	NCIH209	5
Lung	NCIH2106	5.7
Lung	NCIH2110	6.3
Lung	NCIH211	6
Lung	NCIH2122	6.1
Lung	NCIH2126	6.1
Lung	NCIH2141	5.6
Lung	NCIH2170	6.2
Lung	NCIH2171	5.8
Lung	NCIH2172	5.7
Lung	NCIH2196	5.3
Lung	NCIH2227	5.7
Lung	NCIH2228	6.4
Lung	NCIH226	7
Lung	NCIH2286	6.1
Lung	NCIH2291	6.1
Lung	NCIH2342	6.6
Lung	NCIH2347	6.3
Lung	NCIH23	6.1
Lung	NCIH2405	6.2
Lung	NCIH2444	7.1
Lung	NCIH292	7.7
Lung	NCIH322	6.5
Lung	NCIH3255	7.2
Lung	NCIH358	6.3
Lung	NCIH441	6.7
Lung	NCIH446	5.4
Lung	NCIH460	6.2
Lung	NCIH510	5.9
Lung	NCIH520	5.9
Lung	NCIH522	6
Lung	NCIH524	5.8
Lung	NCIH526	5.8
Lung	NCIH596	5.8
Lung	NCIH647	7
Lung	NCIH650	5.5
Lung	NCIH661	6
Lung	NCIH69	5.2
Lung	NCIH727	5.5
Lung	NCIH810	5.4
Lung	NCIH82	5.2
Lung	NCIH838	6.1
Lung	NCIH841	5.7
Lung	NCIH854	5.3
Lung	NCIH889	5.1
Lung	PC14	7
Lung	RERFLCAD1	6.5
Lung	RERFLCAD2	6.8
Lung	RERFLCAI	6.1
Lung	RERFLCKJ	6.4
Lung	RERFLCMS	6.3
Lung	RERFLCSQ1	6.1
Lung	SBC5	6
Lung	SCLC21H	5.7
Lung	SHP77	5.7
Lung	SKLU1	7
Lung	SKMES1	5.9
Lung	SQ1	7.2
Lung	SW1271	6.5
Lung	SW1573	6
Lung	SW900	7.1
Lung	VMRCLCD	7
Lung	VMRCLCP	6.8
Oesophagus	COLO680N	6.6
Oesophagus	ECGI10	6.4
Oesophagus	KYSE140	6.5
Oesophagus	KYSE150	6.5
Oesophagus	KYSE180	6.3
Oesophagus	KYSE270	7
Oesophagus	KYSE30	6.7
Oesophagus	KYSE410	7.3
Oesophagus	KYSE450	5.7
Oesophagus	KYSE510	6.1
Oesophagus	KYSE520	6.3
Oesophagus	KYSE70	6
Oesophagus	OE19	5.9
Oesophagus	OE33	6.7
Oesophagus	TE10	6.7
Oesophagus	TE11	6.4
Oesophagus	TE14	6.5
Oesophagus	TE15	6.7
Oesophagus	TE1	6.2
Oesophagus	TE4	6.3
Oesophagus	TE5	7.1
Oesophagus	TE6	6.3
Oesophagus	TE8	5.9
Oesophagus	TE9	6.1
Oesophagus	TT	6
Ovary	59M	6.9
Ovary	A2780	6.1
Ovary	CAOV3	6.8
Ovary	CAOV4	7.5
Ovary	COLO704	5.7
Ovary	COV318	7.4
Ovary	COV362	6.3
Ovary	COV434	5.2
Ovary	COV504	7.1
Ovary	COV644	6.1
Ovary	EFO21	8.7
Ovary	EFO27	6.3
Ovary	ES2	6.6
Ovary	FUOV1	6.7
Ovary	HEYA8	6.7
Ovary	HS571T	6.6
Ovary	IGROV1	6.1
Ovary	JHOC5	6.7
Ovary	JHOM1	6.2
Ovary	JHOM2B	6.2
Ovary	JHOS2	7.3
Ovary	JHOS4	6.8
Ovary	KURAMOCHI	8.1
Ovary	MCAS	6.7
Ovary	NIHOVCAR3	8.3
Ovary	OAW28	6.7
Ovary	OAW42	6.6
Ovary	OC314	6.5
Ovary	OC316	6.2
Ovary	ONCODG1	8.4
Ovary	OV56	6.6
Ovary	OV7	5.8
Ovary	OV90	6.4
Ovary	OVCAR4	7.9
Ovary	OVCAR8	5.7
Ovary	OVISE	6.6
Ovary	OVK18	5.9
Ovary	OVKATE	7.5
Ovary	OVMANA	6.5
Ovary	OVSAHO	6.6
Ovary	OVTOKO	6.5
Ovary	RMGI	6.3
Ovary	RMUGS	6.2
Ovary	SKOV3	7.1
Ovary	SNU119	6.8
Ovary	SNU840	7.3
Ovary	SNU8	7.7
Ovary	TOV112D	6.2
Ovary	TOV21G	6.7
Ovary	TYKNU	6.1
Pancreas	ASPC1	6.7
Pancreas	BXPC3	7.2
Pancreas	CAPAN1	6.5
Pancreas	CAPAN2	6.7
Pancreas	CFPAC1	7.7
Pancreas	DANG	6.5
Pancreas	HPAC	7.3
Pancreas	HPAFII	7.1
Pancreas	HS766T	6.8
Pancreas	HUPT3	5.7
Pancreas	HUPT4	6.9
Pancreas	KCIMOH1	6.5
Pancreas	KLM1	7.4
Pancreas	KP2	6.5
Pancreas	KP3	6.1
Pancreas	KP4	5.7
Pancreas	L33	6.5
Pancreas	MIAPACA2	6.7
Pancreas	PANC0203	7.4
Pancreas	PANC0213	6.8
Pancreas	PANC0327	7.6
Pancreas	PANC0403	6.4
Pancreas	PANC0504	7.5
Pancreas	PANC0813	6.6
Pancreas	PANC1005	7
Pancreas	PANC1	6.2
Pancreas	PATU8902	7.3
Pancreas	PATU8988S	5.9
Pancreas	PATU8988T	6.5
Pancreas	PK1	6.8
Pancreas	PK45H	6
Pancreas	PK59	6.9
Pancreas	PL45	6.7
Pancreas	PSN1	6.3
Pancreas	QGP1	6
Pancreas	SNU213	6.9
Pancreas	SNU324	6.6
Pancreas	SNU410	6.4
Pancreas	SU8686	7.2
Pancreas	SUIT2	5.3
Pancreas	SW1990	6.8
Pancreas	T3M4	6.1
Pancreas	TCCPAN2	6.6
Pancreas	YAPC	6.3
Pleura	ACCMESO1	6.1
Pleura	DM3	6.5
Pleura	ISTMES1	6.3
Pleura	ISTMES2	6.7
Pleura	JL1	7.1
Pleura	MPP89	6.2
Pleura	MSTO211H	6.6
Pleura	NCIH2052	6.6
Pleura	NCIH2452	7
Pleura	NCIH28	6.2
Prostate	22RV1	6
Prostate	DU145	6.1
Prostate	LNCAPCLONEFGC	6
Prostate	MDAPCA2B	5.6
Prostate	NCIH660	5.9
Prostate	PC3	7.1
Prostate	VCAP	6.2
Salivary gland	A253	5.6
Salivary gland	YD15	6.9
Skin	A101D	6
Skin	A2058	6.5
Skin	A375	6
Skin	C32	6
Skin	CHL1	5.7
Skin	CJM	6.4
Skin	COLO679	5.3
Skin	COLO741	5.8
Skin	COLO783	5.4
Skin	COLO792	5.6
Skin	COLO800	6.3
Skin	COLO818	5.5
Skin	COLO829	6.1
Skin	COLO849	6.3
Skin	G361	5.8
Skin	GRM	7.1
Skin	HMCB	5.8
Skin	HS294T	5.6
Skin	HS600T	6.6
Skin	HS688AT	6.6
Skin	HS695T	5.8
Skin	HS839T	6.7
Skin	HS852T	6.6
Skin	HS895T	6.3
Skin	HS934T	6.6
Skin	HS936T	5.8
Skin	HS939T	5.9
Skin	HS940T	6.9
Skin	HS944T	5.8
Skin	HT144	6.2
Skin	IGR1	5.3
Skin	IGR37	5.8
Skin	IGR39	6.3
Skin	IPC298	5.4
Skin	K029AX	5.6
Skin	LOXIMVI	7.4
Skin	MALME3M	5.4
Skin	MDAMB435S	5.4
Skin	MELHO	5.5
Skin	MELJUSO	6.1
Skin	MEWO	5.4
Skin	RPMI7951	5.4
Skin	RVH421	5.1
Skin	SH4	5.5
Skin	SKMEL1	5.6
Skin	SKMEL24	5.9
Skin	SKMEL28	5.5
Skin	SKMEL2	5.2
Skin	SKMEL30	5.9
Skin	SKMEL31	6.4
Skin	SKMEL3	5.8
Skin	SKMEL5	5.5
Skin	UACC257	5.9
Skin	UACC62	5.6
Skin	WM115	6
Skin	WM1799	5.4
Skin	WM2664	5.8
Skin	WM793	6.2
Skin	WM88	5.2
Skin	WM983B	5.1
Small intestine	HUTU80	6.2
Soft tissue	A204	5.4
Soft tissue	G401	6.5
Soft tissue	G402	7
Soft tissue	GCT	6.1
Soft tissue	HS729	6.7
Soft tissue	HT1080	6.4
Soft tissue	KYM1	5.4
Soft tissue	MESSA	5.5
Soft tissue	RD	6.6
Soft tissue	RH30	7
Soft tissue	RH41	7.1
Soft tissue	RKN	6.2
Soft tissue	S117	6.8
Soft tissue	SJRH30	6.9
Soft tissue	SKLMS1	6.4
Soft tissue	SKUT1	6.3
Soft tissue	TE125T	7.2
Soft tissue	TE159T	7.2
Soft tissue	TE441T	6.2
Soft tissue	TE617T	6
Stomach	2313287	5.7
Stomach	AGS	6.8
Stomach	AZ521	5.9
Stomach	ECC10	5.7
Stomach	ECC12	5.4
Stomach	FU97	6.6
Stomach	GCIY	6.4
Stomach	GSS	5.6
Stomach	GSU	6.3
Stomach	HGC27	6.6
Stomach	HS746T	6.2
Stomach	HUG1N	6.3
Stomach	IM95	6.4
Stomach	KATOIII	6.6
Stomach	KE39	5.8
Stomach	LMSU	7.1
Stomach	MKN1	5.9
Stomach	MKN45	5.9
Stomach	MKN74	6.3
Stomach	MKN7	6.5
Stomach	NCCSTCK140	6.5
Stomach	NCIN87	6.5
Stomach	NUGC2	6.6
Stomach	NUGC3	6.6
Stomach	NUGC4	6.3
Stomach	OCUM1	5.7
Stomach	RERFGC1B	5.6
Stomach	SH10TC	6.6
Stomach	SNU16	6.4
Stomach	SNU1	5.9
Stomach	SNU216	6.6
Stomach	SNU520	5.3
Stomach	SNU5	6
Stomach	SNU601	7.2
Stomach	SNU620	6
Stomach	SNU668	7.4
Stomach	SNU719	7.1
Stomach	TGBC11TKB	6.1
Thyroid	8305C	6.2
Thyroid	8505C	6.8
Thyroid	BCPAP	7.8
Thyroid	BHT101	6.5
Thyroid	CAL62	6.6
Thyroid	CGTHW1	6
Thyroid	FTC133	5.6
Thyroid	FTC238	5.4
Thyroid	ML1	6.4
Thyroid	SW579	7.1
Thyroid	TT2609C02	6.3
Thyroid	TT	6
Upper aerodigestive tract	BHY	6.8
Upper aerodigestive tract	BICR16	6.3
Upper aerodigestive tract	BICR18	6.1
Upper aerodigestive tract	BICR22	7
Upper aerodigestive tract	BICR31	6.1
Upper aerodigestive tract	BICR56	6.9
Upper aerodigestive tract	BICR6	7.1
Upper aerodigestive tract	CAL27	6.4
Upper aerodigestive tract	CAL33	7.4
Upper aerodigestive tract	DETROIT562	7.1
Upper aerodigestive tract	FADU	5.9
Upper aerodigestive tract	HS840T	6.5
Upper aerodigestive tract	HSC2	7
Upper aerodigestive tract	HSC3	6.3
Upper aerodigestive tract	HSC4	6.6
Upper aerodigestive tract	PECAPJ15	5.8
Upper aerodigestive tract	PECAPJ34CLONEC12	5.3
Upper aerodigestive tract	PECAPJ41CLONED2	5.7
Upper aerodigestive tract	PECAPJ49	5.5
Upper aerodigestive tract	SCC15	6.2
Upper aerodigestive tract	SCC25	7
Upper aerodigestive tract	SCC4	6.8
Upper aerodigestive tract	SCC9	6.7
Upper aerodigestive tract	SNU1076	7.2
Upper aerodigestive tract	SNU1214	6.3
Upper aerodigestive tract	SNU46	6.6
Upper aerodigestive tract	SNU899	6.6
Upper aerodigestive tract	YD10B	6.8
Upper aerodigestive tract	YD38	7
Upper aerodigestive tract	YD8	6.7
Urinary tract	5637	6.7
Urinary tract	639V	6.8
Urinary tract	647V	6.4
Urinary tract	BC3C	6.5
Urinary tract	BFTC905	6.4
Urinary tract	CAL29	6.6
Urinary tract	HS172T	6
Urinary tract	HT1197	5.8
Urinary tract	HT1376	6
Urinary tract	J82	6.4
Urinary tract	JMSU1	6.8
Urinary tract	KMBC2	6
Urinary tract	KU1919	6.4
Urinary tract	RT11284	5.7
Urinary tract	RT112	6.8
Urinary tract	RT4	6.6
Urinary tract	SCABER	6.9
Urinary tract	SW1710	6.3
Urinary tract	SW780	7.6
Urinary tract	T24	6.4
Urinary tract	TCCSUP	7.1
Urinary tract	UMUC1	7.9
Urinary tract	UMUC3	6.6
Urinary tract	VMCUB1	6.6

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	31.7
Adrenal gland	27.5
Appendix	40.7
Bone marrow	15.4
Breast	9.6
Cerebral cortex	8.4
Cervix, uterine	22.3
Colon	9.2
Duodenum	10
Endometrium	38.1
Epididymis	16.3
Esophagus	12.2
Fallopian tube	27.9
Gallbladder	26.4
Heart muscle	9.7
Kidney	8.9
Liver	1.7
Lung	33.8
Lymph node	33.1
Ovary	25.5
Pancreas	2.2
Parathyroid gland	42.9
Placenta	28.8
Prostate	18.6
Rectum	5.4
Salivary gland	7.5
Seminal vesicle	25.2
Skeletal muscle	5.9
Skin	24.3
Small intestine	13.3
Smooth muscle	24.9
Spleen	41.7
Stomach	14.6
Testis	10.4
Thyroid gland	20.3
Tonsil	14.7
Urinary bladder	23.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
20636436	overexpression	Acute Lymphoblastic Leukemia	ALL samples showed higher expression levels of HDAC2, HDAC3, HDAC8, HDAC6 and HDAC7 when compared to normal bone marrow samples.
22944197	underexpression	Bladder Urothelial Carcinoma	Prominent changes in UCCs were HDAC2 and/or HDAC8 up-regulation in 11 of 18 cell lines and decreased expression of HDAC4, HDAC5, and/or HDAC7 mRNA in 15 of 18 cell lines.
26853466	overexpression	Glioblastoma	In the current work we show the existence of a subpopulation of patients overexpressing HDAC7 and STAT3 that has particularly poor clinical outcome.
26423403	overexpression	Colorectal Carcinoma	PAK1, NEK6, AURKA, AURKB, and HDAC1 were significantly more overexpressed in the CRAP group compared to the controls (p<0.005).
26259750	overexpression	Colorectal Carcinoma	In addition, there was a significantly higher overexpression of HDAC1 and PAK1 genes in the UC group, and of HDAC1, HDAC7, PAK1 and AURKB genes in the CRC group.
25675295	underexpression	B Acute Lymphoblastic Leukemia; Burkitt Lymphoma	Here we report that histone deacetylase 7 (HDAC7) is underexpressed in pro-B acute lymphoblastic leukemia (pro-B-ALL) and Burkitt lymphoma.
25275504	overexpression	Pancreatic Adenocarcinoma	Mean mRNA transcription levels of PA for HDAC7 and HDAC2 were higher when compared to their counterpart biopsies taken at the tumor periphery (p = 0.0346, 0.0053, respectively).
23724067	overexpression	Colorectal Carcinoma	We found HDAC1, HDAC2, HDAC3, HDAC5, and HDAC7 all to be up-regulated in the field of human CRC.
22237050	overexpression	Chronic Lymphocytic Leukemia	The results showed: (1) HDAC isoenzyme levels in CLL were significantly increased in class I including HDAC1 and HDAC3, in class II including HADC6, HDAC7, HDAC9 and HDAC10, and in class III including SIRT1 and SIRT6; (2) higher expression of HDAC isoenzyme levels was found in ZAP-70+ compared to ZAP-70- patients, and CD44 expression levels were correlated with HDAC isoenzyme expression levels in the majority of HDAC classes.
18506539	overexpression	Pancreatic Adenocarcinoma	Remarkably, 9 of the 11 PA (approximately 81%) showed significant increase of HDAC7 mRNA levels.
28299580	Underexpression	Gastric Carcinoma	We found that HDAC7 was downregulated in cancerous gastric tissues (P=0.0019).
28260932	Overexpression	Chronic Lymphocytic Leukemia	The level of HDAC1 and HDAC7 mRNA expression was significantly increased (P=0.02 and P=0.008, respectively) and HDAC2 and P300 mRNA expression was reduced in patients with CLL (P=0.002 and P=0.001, respectively).

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.369	1.93e-14	16.1	62.1	21.8	Neutral
BRCA	Breast invasive carcinoma	1075	0.262	2.64e-18	14.3	65.8	19.9	Neutral
CESC	Cervical and endocervical cancers	292	0.198	0.000672	5.1	76	18.8	Neutral
COAD	Colon adenocarcinoma	449	0.238	3.38e-07	10	68.4	21.6	Neutral
ESCA	Esophageal carcinoma	183	0.357	6.82e-07	21.3	59.6	19.1	Neutral
GBM	Glioblastoma multiforme	147	0.328	5.09e-05	10.9	79.6	9.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.233	8.95e-08	10.3	73.2	16.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.122	0.00496	1	76.2	22.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.179	0.00229	0.3	60.8	38.9	Gain
LAML	Acute Myeloid Leukemia	166	0.024	0.755	2.4	97.6	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.156	0.000381	13.3	84.2	2.5	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.155	0.00309	10.7	75.8	13.5	Neutral
LUAD	Lung adenocarcinoma	512	0.205	2.8e-06	19.9	52.5	27.5	Neutral
LUSC	Lung squamous cell carcinoma	498	0.229	2.43e-07	10.8	57	32.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.465	1.77e-17	16	48	36	Gain
PAAD	Pancreatic adenocarcinoma	177	-0.089	0.237	15.8	71.2	13	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.075	0.344	1.9	90.1	8	Neutral
PRAD	Prostate adenocarcinoma	491	0.216	1.31e-06	6.1	90.4	3.5	Neutral
READ	Rectum adenocarcinoma	164	0.259	0.000819	10.4	74.4	15.2	Neutral
SARC	Sarcoma	255	0.496	2.83e-17	25.5	57.6	16.9	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.328	1.14e-10	21.8	65.9	12.3	Neutral
STAD	Stomach adenocarcinoma	413	0.114	0.0206	11.4	68.5	20.1	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.386	1.04e-06	0.7	36.7	62.7	Gain
THCA	Thyroid carcinoma	497	-0.071	0.114	0	97.2	2.8	Neutral
THYM	Thymoma	119	-0.011	0.909	5.9	90.8	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.394	2.45e-21	5.8	78.2	16	Neutral

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.229	2.02e-06	17	408	-0.039	0.161	NS/NA
BRCA	Breast invasive carcinoma	-0.145	1.76e-05	83	785	0.014	4.28e-13	NS/NA
CESC	Cervical and endocervical cancers	-0.083	0.144	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.036	0.527	19	297	0.005	0.00811	NS/NA
ESCA	Esophageal carcinoma	-0.203	0.00467	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.363	0.00309	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.107	0.0123	20	522	-0.01	0.0362	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.137	0.0112	24	319	-0.004	0.225	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.115	0.0478	23	275	-0.003	0.163	NS/NA
LAML	Acute Myeloid Leukemia	-0.151	0.0498	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.357	1.36e-17	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.22	6.3e-06	41	373	-0.285	5.38e-23	Decreased
LUAD	Lung adenocarcinoma	-0.141	0.002	21	456	0.024	0.00161	NS/NA
LUSC	Lung squamous cell carcinoma	-0.06	0.244	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.433	0.25	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.362	5.74e-07	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	0	0.995	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.175	4.97e-05	35	498	-0.01	2.73e-06	NS/NA
READ	Rectum adenocarcinoma	-0.224	0.0243	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.05	0.423	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.179	9.6e-05	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.111	0.0323	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.243	0.00233	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.158	0.000182	50	509	-0.005	0.0427	NS/NA
THYM	Thymoma	-0.037	0.682	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.256	2.49e-08	34	431	0.009	0.000582	NS/NA

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0114	Significant	24476821
BRCA	Breast invasive carcinoma	521	4.78e-15	Significant	23000897
COAD	Colon adenocarcinoma	149	0.583	NS	22810696
GBM	Glioblastoma multiforme	157	5.03e-08	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	5.14e-11	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0324	Significant	26536169
LGG	Brain Lower Grade Glioma	513	3.64e-17	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.06e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	1.15e-07	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00821	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.000134	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0239	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.294	NS	26091043
STAD	Stomach adenocarcinoma	277	7.52e-06	Significant	25079317
THCA	Thyroid carcinoma	391	0.0539	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	1.53e-10	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.574	0.0097	Longer
BRCA	Breast invasive carcinoma	1079	0.906	0.664	NS
CESC	Cervical and endocervical cancers	291	1.58	0.156	NS
COAD	Colon adenocarcinoma	439	1.644	0.0973	NS
ESCA	Esophageal carcinoma	184	0.619	0.164	NS
GBM	Glioblastoma multiforme	158	1.847	0.015	Shorter
HNSC	Head and Neck squamous cell carcinoma	518	0.885	0.526	NS
KIRC	Kidney renal clear cell carcinoma	531	2.065	0.000607	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	1.416	0.452	NS
LAML	Acute Myeloid Leukemia	149	2.311	0.00656	Shorter
LGG	Brain Lower Grade Glioma	511	2.551	6.83e-05	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.173	0.525	NS
LUAD	Lung adenocarcinoma	502	1.011	0.96	NS
LUSC	Lung squamous cell carcinoma	494	1.25	0.239	NS
OV	Ovarian serous cystadenocarcinoma	303	1.142	0.514	NS
PAAD	Pancreatic adenocarcinoma	177	1.296	0.359	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.345	0.384	NS
PRAD	Prostate adenocarcinoma	497	1.538	0.637	NS
READ	Rectum adenocarcinoma	159	1.678	0.406	NS
SARC	Sarcoma	259	0.677	0.158	NS
SKCM	Skin Cutaneous Melanoma	459	0.909	0.614	NS
STAD	Stomach adenocarcinoma	388	1.11	0.649	NS
TGCT	Testicular Germ Cell Tumors	134	639671586.807	0.3	NS
THCA	Thyroid carcinoma	500	0.376	0.224	NS
THYM	Thymoma	119	0	0.00859	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.577	0.11	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.168	0.000663	Lower
BRCA	Breast invasive carcinoma	1071	0.019	0.538	NS
CESC	Cervical and endocervical cancers	167	-0.052	0.504	NS
COAD	Colon adenocarcinoma	445	0.089	0.0621	NS
ESCA	Esophageal carcinoma	162	0.103	0.194	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.002	0.967	NS
KIRC	Kidney renal clear cell carcinoma	531	0.063	0.148	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.011	0.864	NS
LIHC	Liver hepatocellular carcinoma	347	0.08	0.139	NS
LUAD	Lung adenocarcinoma	507	-0.008	0.862	NS
LUSC	Lung squamous cell carcinoma	497	0.01	0.823	NS
OV	Ovarian serous cystadenocarcinoma	302	0.05	0.389	NS
PAAD	Pancreatic adenocarcinoma	176	0.182	0.0156	Higher
READ	Rectum adenocarcinoma	156	0.068	0.399	NS
SKCM	Skin Cutaneous Melanoma	410	-0.01	0.835	NS
STAD	Stomach adenocarcinoma	392	0.058	0.254	NS
TGCT	Testicular Germ Cell Tumors	81	-0.113	0.315	NS
THCA	Thyroid carcinoma	499	-0.051	0.26	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.158	0.000387	Higher

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.074	0.221	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.14	0.00179	Higher
KIRC	Kidney renal clear cell carcinoma	525	0	0.999	NS
LGG	Brain Lower Grade Glioma	514	0.228	1.74e-07	Higher
LIHC	Liver hepatocellular carcinoma	366	0.169	0.00116	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.128	0.0277	Higher
PAAD	Pancreatic adenocarcinoma	176	0.13	0.0867	NS
STAD	Stomach adenocarcinoma	406	0.09	0.0703	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.231	7.01e-08	Higher

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug
DB04297	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug

Summary
Symbol	HDAC7
Name	histone deacetylase 7
Aliases	DKFZP586J0917; HDAC7A; histone deacetylase 7A; HD7AA; HD7a
Location	12q13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25675295	B Acute Lymphoblastic Leukemia; Burkitt Lymphoma	downstream	c-Myc	negative regulation	Ectopic expression of HDAC7 induces apoptosis, leads to the downregulation of c-Myc and inhibits the oncogenic potential of cells in vivo, in a xenograft model
28299580	Gastric Carcinoma	partner	Ki-67	Positive correlation	However, the expression of HDAC7 in cancerous gastric tissues positively correlated with Ki-67 expression (P=0.0325) and distant metastasis (P=0.020).