CR2Cancer

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF12203 Glutamine rich N terminal domain of histone deacetylase 4
PF00850 Histone deacetylase domain

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.; FUNCTION: Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone acetylation	H3Kac, H4Kac	H3K, H4K	12590135

> Gene Ontology [ TOP ]
Biological Process	GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0001975 response to amphetamine GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0002521 leukocyte differentiation GO:0006476 protein deacetylation GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010830 regulation of myotube differentiation GO:0014075 response to amine GO:0014706 striated muscle tissue development GO:0014902 myotube differentiation GO:0014904 myotube cell development GO:0016202 regulation of striated muscle tissue development GO:0016570 histone modification GO:0016575 histone deacetylation GO:0018205 peptidyl-lysine modification GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030335 positive regulation of cell migration GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0034983 peptidyl-lysine deacetylation GO:0035601 protein deacylation GO:0040017 positive regulation of locomotion GO:0042113 B cell activation GO:0042692 muscle cell differentiation GO:0043434 response to peptide hormone GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0048514 blood vessel morphogenesis GO:0048634 regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0048741 skeletal muscle fiber development GO:0048742 regulation of skeletal muscle fiber development GO:0048747 muscle fiber development GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051272 positive regulation of cellular component movement GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0070932 histone H3 deacetylation GO:0070933 histone H4 deacetylation GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:0098732 macromolecule deacylation GO:1901342 regulation of vasculature development GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901861 regulation of muscle tissue development GO:1903670 regulation of sprouting angiogenesis GO:1903672 positive regulation of sprouting angiogenesis GO:1904018 positive regulation of vasculature development GO:2000147 positive regulation of cell motility
Molecular Function	GO:0003714 transcription corepressor activity GO:0004407 histone deacetylase activity GO:0005080 protein kinase C binding GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0034979 NAD-dependent protein deacetylase activity GO:0042826 histone deacetylase binding GO:0070491 repressing transcription factor binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0005667 transcription factor complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5492208	c.2389delT	p.F798fs*11	Deletion - Frameshift	Biliary_tract
COSM3942147	c.2920G>T	p.A974S	Substitution - Missense	Oesophagus
COSM1622667	c.1A>G	p.M1V	Substitution - Missense	Liver
COSM1177728	c.1934T>C	p.L645P	Substitution - Missense	Endometrium
COSM4484090	c.2769C>T	p.T923T	Substitution - coding silent	Skin
COSM5591243	c.1693G>A	p.E565K	Substitution - Missense	Skin
COSM4939084	c.1882C>A	p.R628S	Substitution - Missense	Liver
COSM146243	c.3108_3109insT	p.V1037fs*25	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM4745792	c.1987C>T	p.R663*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3374589	c.1407G>A	p.Q469Q	Substitution - coding silent	Thyroid
COSM1209405	c.28G>A	p.V10M	Substitution - Missense	Large_intestine
COSM4482791	c.2640C>T	p.G880G	Substitution - coding silent	Oesophagus
COSM3923316	c.1935G>A	p.L645L	Substitution - coding silent	Skin
COSM3923316	c.1935G>A	p.L645L	Substitution - coding silent	Skin
COSM5647445	c.2782G>C	p.G928R	Substitution - Missense	Oesophagus
COSM4485098	c.2892C>T	p.I964I	Substitution - coding silent	Skin
COSM3636990	c.639G>A	p.K213K	Substitution - coding silent	Skin
COSM1088197	c.2921C>T	p.A974V	Substitution - Missense	Endometrium
COSM1635225	c.2215-2A>T	p.?	Unknown	Liver
COSM4162078	c.2317C>A	p.L773M	Substitution - Missense	Thyroid
COSM222118	c.2045G>A	p.R682Q	Substitution - Missense	Skin
COSM4689735	c.3136G>A	p.D1046N	Substitution - Missense	Large_intestine
COSM745589	c.2776C>A	p.L926I	Substitution - Missense	Lung
COSM5720880	c.500G>A	p.G167E	Substitution - Missense	Skin
COSM4482791	c.2640C>T	p.G880G	Substitution - coding silent	Skin
COSM4819299	c.839C>T	p.S280L	Substitution - Missense	Cervix
COSM5407179	c.1518G>A	p.E506E	Substitution - coding silent	Skin
COSM745595	c.2466+1G>T	p.?	Unknown	Lung
COSM3637079	c.2650C>T	p.P884S	Substitution - Missense	Skin
COSM161473	c.2323-1G>T	p.?	Unknown	Breast
COSM4637177	c.2762G>A	p.G921D	Substitution - Missense	Large_intestine
COSM5407148	c.313A>T	p.K105*	Substitution - Nonsense	Skin
COSM261231	c.513C>T	p.S171S	Substitution - coding silent	Large_intestine
COSM3636982	c.508C>T	p.H170Y	Substitution - Missense	Skin
COSM5886523	c.3023-5C>T	p.?	Unknown	Skin
COSM1209421	c.1226G>A	p.R409Q	Substitution - Missense	Large_intestine
COSM3637020	c.1258C>T	p.P420S	Substitution - Missense	Skin
COSM745631	c.918G>A	p.M306I	Substitution - Missense	Lung
COSM5011730	c.2394T>G	p.F798L	Substitution - Missense	Kidney
COSM40171	c.49G>A	p.G17S	Substitution - Missense	Central_nervous_system
COSM5026709	c.750T>C	p.D250D	Substitution - coding silent	Breast
COSM1209413	c.291A>C	p.K97N	Substitution - Missense	Large_intestine
COSM5717375	c.2485G>A	p.G829S	Substitution - Missense	Skin
COSM5598372	c.1475C>T	p.S492L	Substitution - Missense	Skin
COSM3637053	c.1699G>A	p.E567K	Substitution - Missense	Skin
COSM4481564	c.2520C>T	p.I840I	Substitution - coding silent	Skin
COSM3636974	c.459C>T	p.F153F	Substitution - coding silent	Skin
COSM745619	c.1348A>G	p.N450D	Substitution - Missense	Lung
COSM5919326	c.543-4C>T	p.?	Unknown	Skin
COSM5046328	c.2119A>G	p.T707A	Substitution - Missense	Oesophagus
COSM5717372	c.1899C>T	p.G633G	Substitution - coding silent	Skin
COSM1449796	c.33G>A	p.K11K	Substitution - coding silent	Large_intestine
COSM3637024	c.1267C>T	p.P423S	Substitution - Missense	Skin
COSM1731578	c.2727delG	p.V910fs*2	Deletion - Frameshift	Liver
COSM3879962	c.125G>A	p.R42H	Substitution - Missense	Stomach
COSM5673262	c.2229C>A	p.T743T	Substitution - coding silent	Soft_tissue
COSM1449808	c.798A>G	p.E266E	Substitution - coding silent	Large_intestine
COSM1449843	c.2227A>G	p.T743A	Substitution - Missense	Large_intestine
COSM4925386	c.547G>A	p.A183T	Substitution - Missense	Liver
COSM1088171	c.1428G>T	p.E476D	Substitution - Missense	Endometrium
COSM3879982	c.1563C>T	p.D521D	Substitution - coding silent	Stomach
COSM3781325	c.1947C>T	p.C649C	Substitution - coding silent	Pancreas
COSM265706	c.3090G>T	p.L1030F	Substitution - Missense	Large_intestine
COSM5546790	c.1362_1369delTGCACCTT	p.P456fs*38	Deletion - Frameshift	Prostate
COSM3637032	c.1301C>T	p.S434L	Substitution - Missense	Skin
COSM3768305	c.1256T>C	p.V419A	Substitution - Missense	Liver
COSM3636994	c.656G>A	p.R219Q	Substitution - Missense	Skin
COSM258560	c.1864C>T	p.P622S	Substitution - Missense	Large_intestine
COSM4640788	c.1771C>T	p.R591C	Substitution - Missense	Large_intestine
COSM461622	c.1096C>T	p.P366S	Substitution - Missense	Cervix
COSM1209421	c.1226G>A	p.R409Q	Substitution - Missense	Large_intestine
COSM1088185	c.2057G>A	p.R686Q	Substitution - Missense	Endometrium
COSM5818329	c.321G>C	p.Q107H	Substitution - Missense	Liver
COSM335263	c.2566G>T	p.G856C	Substitution - Missense	Lung
COSM335935	c.963G>T	p.L321L	Substitution - coding silent	Lung
COSM2150774	c.2346C>A	p.P782P	Substitution - coding silent	Central_nervous_system
COSM5899550	c.2882T>C	p.L961P	Substitution - Missense	Skin
COSM4938516	c.1195C>T	p.L399L	Substitution - coding silent	Skin
COSM5686822	c.2893T>A	p.C965S	Substitution - Missense	Soft_tissue
COSM5690861	c.1161G>T	p.E387D	Substitution - Missense	Soft_tissue
COSM4789343	c.1401T>A	p.I467I	Substitution - coding silent	Liver
COSM4788471	c.375G>A	p.Q125Q	Substitution - coding silent	Liver
COSM3637067	c.2126C>T	p.P709L	Substitution - Missense	Skin
COSM4168480	c.1417C>A	p.Q473K	Substitution - Missense	Peritoneum
COSM3879978	c.1327T>C	p.L443L	Substitution - coding silent	Stomach
COSM745611	c.1551G>C	p.A517A	Substitution - coding silent	Lung
COSM5407174	c.1270C>T	p.Q424*	Substitution - Nonsense	Skin
COSM5041712	c.1436A>T	p.K479M	Substitution - Missense	Liver
COSM23307	c.1344C>A	p.P448P	Substitution - coding silent	Lung
COSM3768309	c.1701A>G	p.E567E	Substitution - coding silent	Liver
COSM1088175	c.1476G>A	p.S492S	Substitution - coding silent	Endometrium
COSM3950297	c.2283C>T	p.V761V	Substitution - coding silent	Lung
COSM375108	c.105C>A	p.P35P	Substitution - coding silent	Lung
COSM4837698	c.2358C>T	p.H786H	Substitution - coding silent	Cervix
COSM5720880	c.500G>A	p.G167E	Substitution - Missense	Skin
COSM3923312	c.1545C>T	p.D515D	Substitution - coding silent	Skin
COSM1254022	c.1351C>T	p.R451*	Substitution - Nonsense	Oesophagus
COSM3307044	c.521G>A	p.R174H	Substitution - Missense	Lung
COSM3728445	c.1263_1264delAC	p.H422fs*16	Deletion - Frameshift	Breast
COSM1088167	c.1352G>A	p.R451Q	Substitution - Missense	Prostate
COSM5659725	c.2808T>C	p.F936F	Substitution - coding silent	Soft_tissue
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM361011	c.2586G>A	p.E862E	Substitution - coding silent	Lung
COSM217408	c.3128T>A	p.L1043Q	Substitution - Missense	Liver
COSM3879970	c.306C>A	p.L102L	Substitution - coding silent	Stomach
COSM4959250	c.2587G>A	p.V863I	Substitution - Missense	Liver
COSM3637020	c.1258C>T	p.P420S	Substitution - Missense	Skin
COSM255241	c.628C>A	p.Q210K	Substitution - Missense	Central_nervous_system
COSM5483271	c.1003T>G	p.L335V	Substitution - Missense	Large_intestine
COSM745611	c.1551G>C	p.A517A	Substitution - coding silent	Breast
COSM1662109	c.1825G>C	p.V609L	Substitution - Missense	Kidney
COSM745603	c.1766C>T	p.S589F	Substitution - Missense	Lung
COSM3307242	c.2189C>T	p.S730F	Substitution - Missense	Skin
COSM3923300	c.104C>T	p.P35L	Substitution - Missense	Skin
COSM4923754	c.1583A>G	p.N528S	Substitution - Missense	Liver
COSM3637081	c.2657G>A	p.G886E	Substitution - Missense	Skin
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM3637083	c.2869G>A	p.G957R	Substitution - Missense	Skin
COSM5649551	c.1050C>G	p.L350L	Substitution - coding silent	Oesophagus
COSM3637087	c.2930G>A	p.G977E	Substitution - Missense	Skin
COSM3307216	c.1871C>T	p.P624L	Substitution - Missense	Prostate
COSM1088179	c.1699G>T	p.E567*	Substitution - Nonsense	Endometrium
COSM5683861	c.1534C>A	p.L512I	Substitution - Missense	Soft_tissue
COSM5047642	c.1079C>T	p.T360M	Substitution - Missense	Oesophagus
COSM1449816	c.1041G>A	p.S347S	Substitution - coding silent	Large_intestine
COSM745631	c.918G>A	p.M306I	Substitution - Missense	Skin
COSM3637065	c.2074G>A	p.E692K	Substitution - Missense	Skin
COSM3698323	c.22G>T	p.V8L	Substitution - Missense	Large_intestine
COSM745589	c.2776C>A	p.L926I	Substitution - Missense	Kidney
COSM5673265	c.3009C>A	p.I1003I	Substitution - coding silent	Soft_tissue
COSM3637016	c.1071G>A	p.E357E	Substitution - coding silent	Skin
COSM210977	c.1948G>A	p.V650I	Substitution - Missense	Stomach
COSM219174	c.2819C>T	p.T940M	Substitution - Missense	Large_intestine
COSM4455132	c.558A>G	p.T186T	Substitution - coding silent	Skin
COSM3381880	c.515T>A	p.V172E	Substitution - Missense	Pancreas
COSM3637012	c.1062G>A	p.Q354Q	Substitution - coding silent	Skin
COSM3307315	c.2820G>A	p.T940T	Substitution - coding silent	Skin
COSM3637057	c.1706G>A	p.G569E	Substitution - Missense	Skin
COSM4486978	c.3126C>T	p.S1042S	Substitution - coding silent	Skin
COSM5345318	c.2891T>C	p.I964T	Substitution - Missense	Large_intestine
COSM146243	c.3108_3109insT	p.V1037fs*25	Insertion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM3411890	c.73G>A	p.D25N	Substitution - Missense	Central_nervous_system
COSM382451	c.3123C>A	p.A1041A	Substitution - coding silent	Lung
COSM3307252	c.2264G>A	p.R755H	Substitution - Missense	Stomach
COSM51900	c.2770C>A	p.P924T	Substitution - Missense	Kidney
COSM222118	c.2045G>A	p.R682Q	Substitution - Missense	Endometrium
COSM5908758	c.1657G>A	p.E553K	Substitution - Missense	Skin
COSM3703194	c.2253C>T	p.S751S	Substitution - coding silent	Liver
COSM5724815	c.491C>T	p.P164L	Substitution - Missense	Skin
COSM3636997	c.738C>T	p.L246L	Substitution - coding silent	Skin
COSM1449841	c.1874C>A	p.A625E	Substitution - Missense	Large_intestine
COSM5407153	c.919G>A	p.V307I	Substitution - Missense	Skin
COSM1088155	c.978C>A	p.T326T	Substitution - coding silent	Endometrium
COSM5765611	c.1811A>G	p.E604G	Substitution - Missense	Large_intestine
COSM3307159	c.1539delG	p.D515fs*34	Deletion - Frameshift	Large_intestine
COSM3724687	c.1200G>A	p.Q400Q	Substitution - coding silent	Biliary_tract
COSM255460	c.277C>A	p.L93I	Substitution - Missense	Central_nervous_system
COSM5906810	c.877G>A	p.E293K	Substitution - Missense	Skin
COSM5720885	c.1162G>A	p.G388R	Substitution - Missense	Skin
COSM5461056	c.1821T>C	p.R607R	Substitution - coding silent	Large_intestine
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM1088139	c.138G>A	p.L46L	Substitution - coding silent	Endometrium
COSM217408	c.3128T>A	p.L1043Q	Substitution - Missense	Liver
COSM745627	c.949G>T	p.D317Y	Substitution - Missense	Lung
COSM5618080	c.2380G>A	p.G794R	Substitution - Missense	Breast
COSM1193550	c.67C>A	p.P23T	Substitution - Missense	Lung
COSM3637020	c.1258C>T	p.P420S	Substitution - Missense	Skin
COSM271296	c.122T>A	p.V41D	Substitution - Missense	Large_intestine
COSM222118	c.2045G>A	p.R682Q	Substitution - Missense	Endometrium
COSM485165	c.172C>A	p.Q58K	Substitution - Missense	Kidney
COSM3637036	c.1367C>T	p.P456L	Substitution - Missense	Skin
COSM1088183	c.1720T>C	p.F574L	Substitution - Missense	Endometrium
COSM3923318	c.2428G>A	p.D810N	Substitution - Missense	Skin
COSM346893	c.1541G>A	p.G514E	Substitution - Missense	Lung
COSM1088193	c.2493G>A	p.Q831Q	Substitution - coding silent	Endometrium
COSM745601	c.1801G>C	p.D601H	Substitution - Missense	Lung
COSM128146	c.1551G>T	p.A517A	Substitution - coding silent	Upper_aerodigestive_tract
COSM4689721	c.761T>C	p.V254A	Substitution - Missense	Large_intestine
COSM1488451	c.1846C>T	p.P616S	Substitution - Missense	Breast
COSM1449812	c.961C>A	p.L321M	Substitution - Missense	Large_intestine
COSM1088197	c.2921C>T	p.A974V	Substitution - Missense	Skin
COSM1254018	c.2354A>G	p.H785R	Substitution - Missense	Oesophagus
COSM4998205	c.771C>A	p.F257L	Substitution - Missense	Pancreas
COSM3698326	c.1772G>A	p.R591H	Substitution - Missense	Large_intestine
COSM1194466	c.102G>T	p.M34I	Substitution - Missense	Lung
COSM4926199	c.1460T>A	p.M487K	Substitution - Missense	Liver
COSM3879986	c.2484C>T	p.N828N	Substitution - coding silent	Stomach
COSM5717375	c.2485G>A	p.G829S	Substitution - Missense	Skin
COSM3431460	c.1040C>T	p.S347L	Substitution - Missense	Large_intestine
COSM3636986	c.512C>T	p.S171F	Substitution - Missense	Skin
COSM4959250	c.2587G>A	p.V863I	Substitution - Missense	Liver
COSM5585407	c.90C>T	p.L30L	Substitution - coding silent	Skin
COSM3637085	c.2926C>T	p.L976L	Substitution - coding silent	Skin
COSM5407143	c.307C>T	p.L103L	Substitution - coding silent	Skin
COSM4996823	c.2411C>A	p.T804N	Substitution - Missense	Upper_aerodigestive_tract
COSM1088159	c.1216G>T	p.E406*	Substitution - Nonsense	Stomach
COSM240083	c.2795C>T	p.T932M	Substitution - Missense	Stomach
COSM4745792	c.1987C>T	p.R663*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM3942145	c.2665G>A	p.E889K	Substitution - Missense	Oesophagus
COSM3879966	c.211C>T	p.Q71*	Substitution - Nonsense	Stomach
COSM745615	c.1448A>C	p.Q483P	Substitution - Missense	Lung
COSM219174	c.2819C>T	p.T940M	Substitution - Missense	Adrenal_gland
COSM3637020	c.1258C>T	p.P420S	Substitution - Missense	Skin
COSM41099	c.847A>G	p.N283D	Substitution - Missense	Central_nervous_system
COSM5062361	c.689G>A	p.R230Q	Substitution - Missense	Stomach
COSM275434	c.1988G>A	p.R663Q	Substitution - Missense	Skin
COSM461618	c.2093C>T	p.S698F	Substitution - Missense	Cervix
COSM1254012	c.1882C>T	p.R628C	Substitution - Missense	Oesophagus
COSM182338	c.2540G>A	p.R847H	Substitution - Missense	Stomach
COSM3923314	c.1844C>T	p.S615F	Substitution - Missense	Skin
COSM4481286	c.2498C>T	p.A833V	Substitution - Missense	Skin
COSM1088159	c.1216G>T	p.E406*	Substitution - Nonsense	Endometrium
COSM3663071	c.2701G>A	p.V901M	Substitution - Missense	Liver
COSM1088195	c.2789A>C	p.K930T	Substitution - Missense	Endometrium
COSM4968116	c.3155C>G	p.A1052G	Substitution - Missense	Adrenal_gland
COSM3307087	c.932G>A	p.R311H	Substitution - Missense	Large_intestine
COSM1449816	c.1041G>A	p.S347S	Substitution - coding silent	Large_intestine
COSM275434	c.1988G>A	p.R663Q	Substitution - Missense	Skin
COSM3307095	c.963G>A	p.L321L	Substitution - coding silent	Large_intestine
COSM3637093	c.3099G>A	p.E1033E	Substitution - coding silent	Skin
COSM3637087	c.2930G>A	p.G977E	Substitution - Missense	Skin
COSM3663069	c.1777G>A	p.A593T	Substitution - Missense	Liver
COSM5771093	c.3048G>T	p.M1016I	Substitution - Missense	Breast
COSM5961798	c.1949T>C	p.V650A	Substitution - Missense	Adrenal_gland
COSM3637020	c.1258C>T	p.P420S	Substitution - Missense	Skin
COSM3995493	c.2889C>T	p.A963A	Substitution - coding silent	Kidney
COSM289077	c.1128G>A	p.P376P	Substitution - coding silent	Large_intestine
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM1622669	c.2600T>A	p.L867H	Substitution - Missense	Liver
COSM3637020	c.1258C>T	p.P420S	Substitution - Missense	Skin
COSM745635	c.830G>T	p.G277V	Substitution - Missense	Lung
COSM5805518	c.39A>G	p.E13E	Substitution - coding silent	Liver
COSM281635	c.219G>T	p.E73D	Substitution - Missense	Large_intestine
COSM1549457	c.2356C>T	p.H786Y	Substitution - Missense	Skin
COSM452819	c.3178G>A	p.G1060S	Substitution - Missense	Breast
COSM1449837	c.1761G>A	p.A587A	Substitution - coding silent	Large_intestine
COSM368965	c.1830C>T	p.S610S	Substitution - coding silent	Lung
COSM5578694	c.2182_2185delTTTT	p.F729fs*44	Deletion - Frameshift	Skin
COSM3995491	c.178C>T	p.Q60*	Substitution - Nonsense	Kidney
COSM351586	c.1270C>G	p.Q424E	Substitution - Missense	Lung
COSM1622669	c.2600T>A	p.L867H	Substitution - Missense	Liver
COSM5656548	c.225G>A	p.L75L	Substitution - coding silent	Soft_tissue
COSM1209417	c.435A>C	p.E145D	Substitution - Missense	Large_intestine
COSM1158009	c.1103C>T	p.P368L	Substitution - Missense	Pancreas
COSM4549186	c.349G>A	p.E117K	Substitution - Missense	Skin
COSM3637049	c.1628G>A	p.G543E	Substitution - Missense	Skin
COSM4187452	c.2732T>C	p.L911S	Substitution - Missense	Kidney
COSM3431456	c.433G>T	p.E145*	Substitution - Nonsense	Large_intestine
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM1733711	c.2192C>T	p.S731L	Substitution - Missense	Pancreas
COSM345953	c.3120G>T	p.L1040L	Substitution - coding silent	Lung
COSM1449820	c.1073C>T	p.T358M	Substitution - Missense	Large_intestine
COSM3431464	c.3003G>T	p.Q1001H	Substitution - Missense	Large_intestine
COSM3636978	c.502A>T	p.K168*	Substitution - Nonsense	Skin
COSM5596831	c.2564C>T	p.P855L	Substitution - Missense	Skin
COSM1312938	c.1494G>A	p.L498L	Substitution - coding silent	Urinary_tract
COSM5629461	c.722G>A	p.R241K	Substitution - Missense	Oesophagus
COSM4554274	c.499G>A	p.G167R	Substitution - Missense	Skin
COSM4994357	c.886G>T	p.V296F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM219174	c.2819C>T	p.T940M	Substitution - Missense	Breast
COSM5407169	c.1231C>T	p.Q411*	Substitution - Nonsense	Skin
COSM5816955	c.3085C>T	p.Q1029*	Substitution - Nonsense	Liver
COSM5407163	c.1163G>A	p.G388E	Substitution - Missense	Skin
COSM4431015	c.2170G>T	p.D724Y	Substitution - Missense	Oesophagus
COSM4566156	c.3189_3190GG>AA	p.M1063_E1064>IK	Complex - compound substitution	Skin
COSM3950299	c.2379-4G>T	p.?	Unknown	Lung
COSM1254022	c.1351C>T	p.R451*	Substitution - Nonsense	Oesophagus
COSM3674895	c.1333C>A	p.R445S	Substitution - Missense	Prostate
COSM275434	c.1988G>A	p.R663Q	Substitution - Missense	Pancreas
COSM3923304	c.105C>T	p.P35P	Substitution - coding silent	Skin
COSM4985386	c.416-2A>T	p.?	Unknown	Soft_tissue
COSM255460	c.277C>A	p.L93I	Substitution - Missense	Skin
COSM461622	c.1096C>T	p.P366S	Substitution - Missense	Skin
COSM4632424	c.1572C>A	p.P524P	Substitution - coding silent	Large_intestine
COSM5887336	c.2448G>T	p.K816N	Substitution - Missense	Skin
COSM3636994	c.656G>A	p.R219Q	Substitution - Missense	Skin
COSM1209395	c.1883G>A	p.R628H	Substitution - Missense	Large_intestine
COSM1088151	c.933C>T	p.R311R	Substitution - coding silent	Endometrium
COSM5717375	c.2485G>A	p.G829S	Substitution - Missense	Skin
COSM1449804	c.542C>T	p.T181M	Substitution - Missense	Large_intestine
COSM3307040	c.514G>A	p.V172M	Substitution - Missense	Pancreas
COSM4464630	c.1343C>T	p.P448L	Substitution - Missense	Skin
COSM4919159	c.2322+1G>A	p.?	Unknown	Liver
COSM4393551	c.2878G>T	p.D960Y	Substitution - Missense	Prostate
COSM240083	c.2795C>T	p.T932M	Substitution - Missense	Large_intestine
COSM3685136	c.23-2A>T	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM3637028	c.1276C>T	p.P426S	Substitution - Missense	Skin
COSM5732886	c.1450C>A	p.Q484K	Substitution - Missense	Pancreas
COSM1449800	c.213G>A	p.Q71Q	Substitution - coding silent	Large_intestine
COSM4539173	c.2656G>A	p.G886R	Substitution - Missense	Skin
COSM745587	c.2823G>T	p.K941N	Substitution - Missense	Lung
COSM1622667	c.1A>G	p.M1V	Substitution - Missense	Liver
COSM3394660	c.549C>T	p.A183A	Substitution - coding silent	Pancreas
COSM4508092	c.648C>T	p.F216F	Substitution - coding silent	Skin
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM3637067	c.2126C>T	p.P709L	Substitution - Missense	Skin
COSM3307028	c.480G>A	p.T160T	Substitution - coding silent	Skin
COSM4689729	c.2043G>T	p.E681D	Substitution - Missense	Large_intestine
COSM4453067	c.2483A>G	p.N828S	Substitution - Missense	Skin
COSM3778308	c.2139G>T	p.Q713H	Substitution - Missense	Urinary_tract
COSM5494868	c.479C>T	p.T160M	Substitution - Missense	Biliary_tract
COSM335935	c.963G>T	p.L321L	Substitution - coding silent	Lung
COSM281638	c.748G>T	p.D250Y	Substitution - Missense	Large_intestine
COSM5991436	c.1570C>G	p.P524A	Substitution - Missense	Prostate
COSM5720880	c.500G>A	p.G167E	Substitution - Missense	Skin
COSM1088163	c.1225C>T	p.R409*	Substitution - Nonsense	Endometrium
COSM5624665	c.990G>T	p.L330F	Substitution - Missense	Oesophagus
COSM3637069	c.2135G>A	p.G712E	Substitution - Missense	Skin
COSM4570790	c.194T>C	p.I65T	Substitution - Missense	Skin
COSM1088163	c.1225C>T	p.R409*	Substitution - Nonsense	Large_intestine
COSM3636982	c.508C>T	p.H170Y	Substitution - Missense	Skin
COSM3637071	c.2467G>A	p.D823N	Substitution - Missense	Skin
COSM4913331	c.1281G>A	p.L427L	Substitution - coding silent	Liver
COSM3637075	c.2553G>A	p.G851G	Substitution - coding silent	Skin
COSM5407182	c.2117G>A	p.G706D	Substitution - Missense	Skin
COSM452815	c.2057G>T	p.R686L	Substitution - Missense	Breast
COSM3923308	c.884C>T	p.S295L	Substitution - Missense	Skin
COSM1088147	c.365G>A	p.R122H	Substitution - Missense	Endometrium
COSM3724687	c.1200G>A	p.Q400Q	Substitution - coding silent	Lung
COSM1312940	c.1749G>A	p.T583T	Substitution - coding silent	Biliary_tract
COSM1088167	c.1352G>A	p.R451Q	Substitution - Missense	Endometrium
COSM1088199	c.3116C>A	p.A1039D	Substitution - Missense	Endometrium
COSM1496650	c.1569G>A	p.A523A	Substitution - coding silent	Kidney
COSM3637059	c.1779T>G	p.A593A	Substitution - coding silent	Skin
COSM4162076	c.2315A>G	p.E772G	Substitution - Missense	Thyroid
COSM4632426	c.1991T>C	p.I664T	Substitution - Missense	Large_intestine
COSM5657248	c.2134G>T	p.G712*	Substitution - Nonsense	Soft_tissue
COSM1254016	c.1398C>A	p.V466V	Substitution - coding silent	Oesophagus
COSM3686358	c.2937+3delA	p.?	Unknown	Large_intestine
COSM1209399	c.68C>A	p.P23H	Substitution - Missense	Large_intestine
COSM1549485	c.1334G>A	p.R445H	Substitution - Missense	Large_intestine
COSM219174	c.2819C>T	p.T940M	Substitution - Missense	Breast
COSM222118	c.2045G>A	p.R682Q	Substitution - Missense	Endometrium
COSM5407186	c.2563C>T	p.P855S	Substitution - Missense	Skin
COSM4689731	c.2080_2081insA	p.L695fs*5	Insertion - Frameshift	Large_intestine
COSM1449816	c.1041G>A	p.S347S	Substitution - coding silent	Large_intestine
COSM5407192	c.2647C>T	p.P883S	Substitution - Missense	Skin
COSM5497878	c.2906A>G	p.E969G	Substitution - Missense	Biliary_tract
COSM5062365	c.820C>T	p.P274S	Substitution - Missense	Stomach
COSM5407189	c.2598C>T	p.G866G	Substitution - coding silent	Skin
COSM3636982	c.508C>T	p.H170Y	Substitution - Missense	Skin
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM1088163	c.1225C>T	p.R409*	Substitution - Nonsense	Liver
COSM3306962	c.137T>C	p.L46S	Substitution - Missense	Upper_aerodigestive_tract
COSM3637065	c.2074G>A	p.E692K	Substitution - Missense	Skin
COSM1088175	c.1476G>A	p.S492S	Substitution - coding silent	Skin
COSM4649096	c.1808T>C	p.L603S	Substitution - Missense	Large_intestine
COSM231103	c.2684+2T>C	p.?	Unknown	Skin
COSM3637045	c.1570C>T	p.P524S	Substitution - Missense	Skin
COSM3879984	c.1849G>A	p.A617T	Substitution - Missense	Stomach
COSM289077	c.1128G>A	p.P376P	Substitution - coding silent	Large_intestine
COSM4689725	c.1344C>T	p.P448P	Substitution - coding silent	Large_intestine
COSM1449850	c.3138T>C	p.D1046D	Substitution - coding silent	Large_intestine
COSM5717372	c.1899C>T	p.G633G	Substitution - coding silent	Skin
COSM5746698	c.880A>G	p.T294A	Substitution - Missense	Pancreas
COSM1088187	c.2213G>T	p.G738V	Substitution - Missense	Endometrium
COSM3637091	c.3066C>T	p.G1022G	Substitution - coding silent	Skin
COSM1209409	c.183G>T	p.K61N	Substitution - Missense	Large_intestine
COSM5932055	c.382C>T	p.P128S	Substitution - Missense	Skin
COSM1209401	c.2358C>G	p.H786Q	Substitution - Missense	Large_intestine
COSM281641	c.2113T>C	p.Y705H	Substitution - Missense	Large_intestine
COSM1622671	c.2636G>A	p.G879D	Substitution - Missense	Liver
COSM3394656	c.513C>A	p.S171S	Substitution - coding silent	Pancreas
COSM161473	c.2323-1G>T	p.?	Unknown	Large_intestine
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM272763	c.2412C>T	p.T804T	Substitution - coding silent	Large_intestine
COSM5658901	c.1077G>T	p.Q359H	Substitution - Missense	Soft_tissue
COSM1158009	c.1103C>T	p.P368L	Substitution - Missense	Pancreas
COSM5482112	c.2803+7A>G	p.?	Unknown	Large_intestine
COSM5720885	c.1162G>A	p.G388R	Substitution - Missense	Skin
COSM4598599	c.2670C>A	p.Y890*	Substitution - Nonsense	Upper_aerodigestive_tract
COSM3637073	c.2545G>A	p.D849N	Substitution - Missense	Skin
COSM1449816	c.1041G>A	p.S347S	Substitution - coding silent	Skin
COSM5731682	c.1012C>T	p.P338S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3307315	c.2820G>A	p.T940T	Substitution - coding silent	Skin
COSM1088175	c.1476G>A	p.S492S	Substitution - coding silent	Skin
COSM1312940	c.1749G>A	p.T583T	Substitution - coding silent	Large_intestine
COSM3637008	c.991C>T	p.P331S	Substitution - Missense	Skin
COSM5062358	c.52C>A	p.L18M	Substitution - Missense	Stomach
COSM4587296	c.233A>G	p.Q78R	Substitution - Missense	Bone
COSM745593	c.2469T>G	p.D823E	Substitution - Missense	Lung
COSM3663071	c.2701G>A	p.V901M	Substitution - Missense	Liver
COSM161473	c.2323-1G>T	p.?	Unknown	Large_intestine
COSM3785059	c.301G>A	p.E101K	Substitution - Missense	Pancreas
COSM745591	c.2698C>A	p.P900T	Substitution - Missense	Lung
COSM1088185	c.2057G>A	p.R686Q	Substitution - Missense	Skin
COSM3637067	c.2126C>T	p.P709L	Substitution - Missense	Skin
COSM346890	c.57G>T	p.E19D	Substitution - Missense	Lung
COSM3307032	c.483A>C	p.K161N	Substitution - Missense	Stomach
COSM118223	c.678C>T	p.N226N	Substitution - coding silent	Ovary
COSM1088167	c.1352G>A	p.R451Q	Substitution - Missense	Stomach
COSM5737880	c.2938-1G>A	p.?	Unknown	Small_intestine
COSM3637040	c.1370T>G	p.L457W	Substitution - Missense	Skin
COSM1312940	c.1749G>A	p.T583T	Substitution - coding silent	Large_intestine
COSM1088191	c.2350G>T	p.G784C	Substitution - Missense	Endometrium
COSM4689733	c.2344delC	p.P783fs*26	Deletion - Frameshift	Large_intestine
COSM745601	c.1801G>C	p.D601H	Substitution - Missense	Large_intestine
COSM387733	c.1551G>A	p.A517A	Substitution - coding silent	Lung
COSM3637089	c.3063G>A	p.R1021R	Substitution - coding silent	Skin
COSM4616348	c.1760C>T	p.A587V	Substitution - Missense	Large_intestine
COSM4446178	c.1910-3A>C	p.?	Unknown	Skin
COSM402855	c.1541G>T	p.G514V	Substitution - Missense	Lung
COSM1449848	c.2539C>T	p.R847C	Substitution - Missense	Large_intestine
COSM346893	c.1541G>A	p.G514E	Substitution - Missense	Skin
COSM182369	c.2976G>A	p.P992P	Substitution - coding silent	Large_intestine
COSM485169	c.1253G>T	p.G418V	Substitution - Missense	Kidney
COSM745607	c.1589C>T	p.T530I	Substitution - Missense	Lung
COSM1488451	c.1846C>T	p.P616S	Substitution - Missense	Large_intestine
COSM5922616	c.1680T>G	p.D560E	Substitution - Missense	Skin
COSM5720885	c.1162G>A	p.G388R	Substitution - Missense	Skin
COSM3637004	c.908C>T	p.A303V	Substitution - Missense	Skin
COSM5717372	c.1899C>T	p.G633G	Substitution - coding silent	Skin
COSM4938516	c.1195C>T	p.L399L	Substitution - coding silent	Liver
COSM5806550	c.521G>C	p.R174P	Substitution - Missense	Liver
COSM3674895	c.1333C>A	p.R445S	Substitution - Missense	Prostate
COSM371175	c.2404G>T	p.A802S	Substitution - Missense	Lung
COSM335261	c.1036G>C	p.A346P	Substitution - Missense	Lung
COSM1088167	c.1352G>A	p.R451Q	Substitution - Missense	Prostate
COSM745639	c.448C>A	p.L150I	Substitution - Missense	Lung
COSM3307319	c.2872G>T	p.G958*	Substitution - Nonsense	Large_intestine
COSM1088143	c.199G>A	p.E67K	Substitution - Missense	Endometrium
COSM1312940	c.1749G>A	p.T583T	Substitution - coding silent	Urinary_tract
COSM362528	c.553C>A	p.H185N	Substitution - Missense	Lung
COSM1568481	c.2909C>A	p.A970D	Substitution - Missense	Large_intestine
COSM5720885	c.1162G>A	p.G388R	Substitution - Missense	Skin
COSM23306	c.1594A>C	p.S532R	Substitution - Missense	Lung
COSM275434	c.1988G>A	p.R663Q	Substitution - Missense	Skin
COSM4788471	c.375G>A	p.Q125Q	Substitution - coding silent	Liver
COSM1449852	c.3170+1G>A	p.?	Unknown	Large_intestine
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM3307052	c.542+1G>A	p.?	Unknown	Upper_aerodigestive_tract
COSM1622671	c.2636G>A	p.G879D	Substitution - Missense	Liver
COSM1449839	c.1791G>A	p.A597A	Substitution - coding silent	Large_intestine
COSM5581290	c.2630G>A	p.W877*	Substitution - Nonsense	Skin
COSM3307028	c.480G>A	p.T160T	Substitution - coding silent	Skin
COSM1449846	c.2494C>T	p.Q832*	Substitution - Nonsense	Large_intestine
COSM3637032	c.1301C>T	p.S434L	Substitution - Missense	Skin
COSM4464630	c.1343C>T	p.P448L	Substitution - Missense	Skin
COSM377975	c.3080G>C	p.G1027A	Substitution - Missense	Lung
COSM3722015	c.1656G>C	p.E552D	Substitution - Missense	Upper_aerodigestive_tract
COSM5348060	c.1543delG	p.D515fs*34	Deletion - Frameshift	Liver
COSM421511	c.2813A>T	p.H938L	Substitution - Missense	Urinary_tract
COSM240083	c.2795C>T	p.T932M	Substitution - Missense	Prostate
COSM240083	c.2795C>T	p.T932M	Substitution - Missense	Breast
COSM3637000	c.767C>T	p.S256L	Substitution - Missense	Skin
COSM4689727	c.1995G>A	p.Q665Q	Substitution - coding silent	Large_intestine
COSM400066	c.54G>C	p.L18L	Substitution - coding silent	Lung
COSM5503216	c.1316G>T	p.G439V	Substitution - Missense	Biliary_tract
COSM745599	c.1916C>T	p.A639V	Substitution - Missense	Lung
COSM5720880	c.500G>A	p.G167E	Substitution - Missense	Skin
COSM5903638	c.2249C>T	p.S750L	Substitution - Missense	Skin
COSM1088175	c.1476G>A	p.S492S	Substitution - coding silent	Skin
COSM3307242	c.2189C>T	p.S730F	Substitution - Missense	Skin
COSM5368953	c.267G>T	p.L89F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM210977	c.1948G>A	p.V650I	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4837698	c.2358C>T	p.H786H	Substitution - coding silent	Breast
COSM5566822	c.230G>A	p.R77Q	Substitution - Missense	Prostate
COSM5928930	c.2555A>G	p.N852S	Substitution - Missense	Skin
COSM4745792	c.1987C>T	p.R663*	Substitution - Nonsense	Haematopoietic_and_lymphoid_tissue
COSM5407158	c.986C>T	p.S329F	Substitution - Missense	Skin
COSM5587970	c.871G>A	p.E291K	Substitution - Missense	Skin
COSM1088189	c.2222G>C	p.S741T	Substitution - Missense	Endometrium
COSM5902840	c.2450T>A	p.I817K	Substitution - Missense	Skin
COSM391230	c.2383delT	p.F795fs*14	Deletion - Frameshift	Lung
COSM4981007	c.2828T>A	p.L943*	Substitution - Nonsense	Oesophagus
COSM421509	c.2883C>G	p.L961L	Substitution - coding silent	Urinary_tract
COSM3307315	c.2820G>A	p.T940T	Substitution - coding silent	Stomach
COSM5724815	c.491C>T	p.P164L	Substitution - Missense	Skin
COSM1449831	c.1661_1667delCAGTGGA	p.D556fs*46	Deletion - Frameshift	Large_intestine
COSM3923314	c.1844C>T	p.S615F	Substitution - Missense	Skin
COSM3879974	c.396C>A	p.G132G	Substitution - coding silent	Stomach
COSM3785061	c.2050C>A	p.Q684K	Substitution - Missense	Pancreas
COSM3637095	c.3125C>T	p.S1042F	Substitution - Missense	Skin
COSM3431462	c.2797G>T	p.A933S	Substitution - Missense	Large_intestine
COSM5018196	c.1461G>T	p.M487I	Substitution - Missense	Soft_tissue
COSM5407163	c.1163G>A	p.G388E	Substitution - Missense	Skin
COSM1472083	c.1074G>A	p.T358T	Substitution - coding silent	Prostate
COSM394345	c.1006G>T	p.G336W	Substitution - Missense	Lung
COSM3307087	c.932G>A	p.R311H	Substitution - Missense	Large_intestine
COSM1088167	c.1352G>A	p.R451Q	Substitution - Missense	Prostate
COSM3307232	c.2009G>A	p.R670Q	Substitution - Missense	Skin
COSM1449816	c.1041G>A	p.S347S	Substitution - coding silent	Large_intestine
COSM5724815	c.491C>T	p.P164L	Substitution - Missense	Skin
COSM4911568	c.2390T>A	p.F797Y	Substitution - Missense	Liver
COSM3637063	c.1824C>T	p.L608L	Substitution - coding silent	Skin
COSM222118	c.2045G>A	p.R682Q	Substitution - Missense	Skin
COSM4418369	c.1909+6A>C	p.?	Unknown	Haematopoietic_and_lymphoid_tissue
COSM219174	c.2819C>T	p.T940M	Substitution - Missense	Oesophagus
COSM745597	c.1963A>T	p.T655S	Substitution - Missense	Lung
COSM4839425	c.702A>C	p.K234N	Substitution - Missense	Cervix
COSM1743479	c.81G>A	p.R27R	Substitution - coding silent	Biliary_tract
COSM381598	c.2866G>T	p.E956*	Substitution - Nonsense	Lung
COSM281635	c.219G>T	p.E73D	Substitution - Missense	Large_intestine
COSM4525169	c.1313G>A	p.R438K	Substitution - Missense	Skin
COSM1662111	c.2312G>A	p.G771E	Substitution - Missense	Kidney
COSM3637032	c.1301C>T	p.S434L	Substitution - Missense	Skin
COSM5789387	c.730C>A	p.P244T	Substitution - Missense	Breast
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM3637061	c.1818C>T	p.H606H	Substitution - coding silent	Skin
COSM3307139	c.1333C>T	p.R445C	Substitution - Missense	Stomach
COSM4984750	c.2494C>A	p.Q832K	Substitution - Missense	Oesophagus
COSM4168480	c.1417C>A	p.Q473K	Substitution - Missense	Stomach
COSM3636969	c.43C>T	p.P15S	Substitution - Missense	Skin
COSM4750671	c.570A>T	p.Q190H	Substitution - Missense	Stomach
COSM452817	c.2322+1G>T	p.?	Unknown	Breast
COSM275434	c.1988G>A	p.R663Q	Substitution - Missense	Large_intestine
COSM3637020	c.1258C>T	p.P420S	Substitution - Missense	Skin
COSM5697273	c.418G>A	p.A140T	Substitution - Missense	Soft_tissue
COSM2150774	c.2346C>A	p.P782P	Substitution - coding silent	Central_nervous_system
COSM341482	c.2514C>A	p.P838P	Substitution - coding silent	Lung
COSM4796668	c.165G>A	p.Q55Q	Substitution - coding silent	Liver
COSM4796668	c.165G>A	p.Q55Q	Substitution - coding silent	Liver
COSM400673	c.2070G>A	p.L690L	Substitution - coding silent	Lung
COSM3307234	c.2044C>T	p.R682*	Substitution - Nonsense	Pancreas
COSM3636969	c.43C>T	p.P15S	Substitution - Missense	Skin
COSM3637077	c.2584G>A	p.E862K	Substitution - Missense	Skin
COSM3307315	c.2820G>A	p.T940T	Substitution - coding silent	Skin
COSM128144	c.486C>T	p.D162D	Substitution - coding silent	Upper_aerodigestive_tract
COSM217408	c.3128T>A	p.L1043Q	Substitution - Missense	Liver
COSM4789343	c.1401T>A	p.I467I	Substitution - coding silent	Liver
COSM358027	c.1106G>C	p.G369A	Substitution - Missense	Lung
COSM1738286	c.1757G>A	p.R586H	Substitution - Missense	Ovary
COSM255460	c.277C>A	p.L93I	Substitution - Missense	Central_nervous_system
COSM4535969	c.2254G>A	p.G752S	Substitution - Missense	Skin
COSM4900039	c.274G>A	p.E92K	Substitution - Missense	Skin

> Text Mining based Variations [ TOP ]
There is no record for HDAC9.

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UKV0	220	S	Phosphoserine	-	No	None detected
Q9UKV0	240	S	Phosphoserine	-	No	None detected
Q9UKV0	451	S	Phosphoserine	-	No	None detected
Q9UKV0	554	S	Phosphoserine	-	No	None detected

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	2.673	0.997	-1.518	0.00222	Under
BRCA	Breast invasive carcinoma	112	1100	3.076	2.177	-0.638	8.93e-06	Under
CESC	Cervical and endocervical cancers	3	306	4.591	1.866	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.653	1.357	-2.394	3.29e-24	Under
ESCA	Esophageal carcinoma	11	185	2.585	3.369	0.271	0.724	NS
GBM	Glioblastoma multiforme	5	166	4.711	4.716	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	1.622	2.645	0.633	0.0113	Over
KIRC	Kidney renal clear cell carcinoma	72	534	2.852	2.923	-0.06	0.614	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	2.581	3.056	0.318	0.196	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.063	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.275	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	0.836	-0.536	-1.157	9.07e-08	Under
LUAD	Lung adenocarcinoma	59	517	2.746	2.86	-0.031	0.887	NS
LUSC	Lung squamous cell carcinoma	51	501	2.751	2.921	0.072	0.772	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.32	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.041	3.51	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	0.611	5.878	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.186	3.429	-0.807	0.000892	Under
READ	Rectum adenocarcinoma	10	167	3.949	1.183	-2.689	3.25e-09	Under
SARC	Sarcoma	2	263	2.55	3.08	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.495	2.028	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.335	3.426	-0.682	0.0208	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	4.015	NA	NA	NA
THCA	Thyroid carcinoma	59	509	1.936	3.598	1.375	1.1e-15	Over
THYM	Thymoma	2	120	2.678	2.268	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.187	3.686	-0.443	0.0784	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	5.3
Autonomic ganglia	CHP212	4.3
Autonomic ganglia	IMR32	4.5
Autonomic ganglia	KELLY	5.5
Autonomic ganglia	KPNRTBM1	6
Autonomic ganglia	KPNSI9S	5.1
Autonomic ganglia	KPNYN	6.1
Autonomic ganglia	MHHNB11	5
Autonomic ganglia	NB1	5.9
Autonomic ganglia	NH6	6.1
Autonomic ganglia	SHSY5Y	7.7
Autonomic ganglia	SIMA	4.3
Autonomic ganglia	SKNAS	4.2
Autonomic ganglia	SKNBE2	5.9
Autonomic ganglia	SKNDZ	4.8
Autonomic ganglia	SKNFI	6.6
Autonomic ganglia	SKNSH	5.7
Biliary tract	HUCCT1	5.3
Biliary tract	HUH28	4.7
Biliary tract	SNU1079	4.7
Biliary tract	SNU1196	4.6
Biliary tract	SNU245	4.1
Biliary tract	SNU308	6
Biliary tract	SNU478	5
Bone	143B	4.4
Bone	A673	5.3
Bone	CADOES1	4.9
Bone	CAL78	4.7
Bone	G292CLONEA141B1	4.7
Bone	HOS	4.1
Bone	HS706T	4.8
Bone	HS737T	5.5
Bone	HS819T	4.5
Bone	HS821T	4.9
Bone	HS822T	5.1
Bone	HS863T	5.2
Bone	HS870T	4.4
Bone	HS888T	4.5
Bone	MG63	4.3
Bone	MHHES1	4.4
Bone	OUMS27	5.2
Bone	RDES	4.3
Bone	SJSA1	6.5
Bone	SKES1	4.3
Bone	SKNMC	5.1
Bone	SW1353	5
Bone	T173	4.6
Bone	TC71	5.8
Bone	U2OS	4.5
Breast	AU565	4.2
Breast	BT20	4.3
Breast	BT474	4.3
Breast	BT483	4.2
Breast	BT549	4.5
Breast	CAL120	4.8
Breast	CAL148	5.3
Breast	CAL51	6.5
Breast	CAL851	5
Breast	CAMA1	4.5
Breast	DU4475	5.9
Breast	EFM192A	4.3
Breast	EFM19	4.2
Breast	EVSAT	7.3
Breast	HCC1143	5.3
Breast	HCC1187	4.1
Breast	HCC1395	4.8
Breast	HCC1419	4.7
Breast	HCC1428	4.2
Breast	HCC1500	4.4
Breast	HCC1569	4.5
Breast	HCC1599	4.1
Breast	HCC1806	4.5
Breast	HCC1937	4.9
Breast	HCC1954	4.4
Breast	HCC202	4.5
Breast	HCC2157	4.1
Breast	HCC2218	4
Breast	HCC38	4
Breast	HCC70	5
Breast	HDQP1	4.7
Breast	HMC18	4.6
Breast	HS274T	5.6
Breast	HS281T	5.5
Breast	HS343T	4.4
Breast	HS578T	4.9
Breast	HS606T	4.5
Breast	HS739T	4.9
Breast	HS742T	4.5
Breast	JIMT1	4.4
Breast	KPL1	4.2
Breast	MCF7	4.3
Breast	MDAMB134VI	4
Breast	MDAMB157	5.3
Breast	MDAMB175VII	4.2
Breast	MDAMB231	5.1
Breast	MDAMB361	4.2
Breast	MDAMB415	4.8
Breast	MDAMB436	5.3
Breast	MDAMB453	4.2
Breast	MDAMB468	4.9
Breast	SKBR3	4.3
Breast	T47D	4.1
Breast	UACC812	4.2
Breast	UACC893	4.2
Breast	YMB1	4.2
Breast	ZR751	4.3
Breast	ZR7530	4.7
Central nervous system	1321N1	6.2
Central nervous system	42MGBA	4.8
Central nervous system	8MGBA	4.4
Central nervous system	A172	5
Central nervous system	AM38	4.6
Central nervous system	BECKER	4.3
Central nervous system	CAS1	6.3
Central nervous system	CCFSTTG1	5.2
Central nervous system	D283MED	4.4
Central nervous system	D341MED	4.3
Central nervous system	DAOY	5.3
Central nervous system	DBTRG05MG	4.9
Central nervous system	DKMG	6.2
Central nervous system	GAMG	6.5
Central nervous system	GB1	7
Central nervous system	GI1	4.6
Central nervous system	GMS10	4.4
Central nervous system	GOS3	5.9
Central nervous system	H4	4.7
Central nervous system	HS683	5.1
Central nervous system	KALS1	5.1
Central nervous system	KG1C	4.9
Central nervous system	KNS42	5.8
Central nervous system	KNS60	4.9
Central nervous system	KNS81	5.8
Central nervous system	KS1	6
Central nervous system	LN18	4.4
Central nervous system	LN229	5
Central nervous system	M059K	5.4
Central nervous system	MOGGCCM	5.5
Central nervous system	MOGGUVW	5.5
Central nervous system	NMCG1	6
Central nervous system	ONS76	4.4
Central nervous system	SF126	4.3
Central nervous system	SF295	5.5
Central nervous system	SNB19	6.9
Central nervous system	SNU1105	6.4
Central nervous system	SNU201	5.4
Central nervous system	SNU466	5.7
Central nervous system	SNU489	5.7
Central nervous system	SNU626	5.5
Central nervous system	SNU738	4.3
Central nervous system	SW1088	5.3
Central nervous system	SW1783	4.3
Central nervous system	T98G	4.4
Central nervous system	TM31	5.3
Central nervous system	U118MG	4.8
Central nervous system	U138MG	5.7
Central nervous system	U251MG	6.1
Central nervous system	U87MG	5
Central nervous system	YH13	6.4
Central nervous system	YKG1	5.7
Endometrium	AN3CA	4.3
Endometrium	COLO684	5
Endometrium	EFE184	5.1
Endometrium	EN	4.1
Endometrium	ESS1	4.1
Endometrium	HEC108	4.8
Endometrium	HEC151	4.7
Endometrium	HEC1A	4.4
Endometrium	HEC1B	4.1
Endometrium	HEC251	5.1
Endometrium	HEC265	4.8
Endometrium	HEC50B	4.9
Endometrium	HEC59	4.4
Endometrium	HEC6	4.5
Endometrium	ISHIKAWAHERAKLIO02ER	6
Endometrium	JHUEM1	5.2
Endometrium	JHUEM2	4.2
Endometrium	JHUEM3	4.8
Endometrium	KLE	6.8
Endometrium	MFE280	5.1
Endometrium	MFE296	4.3
Endometrium	MFE319	5.8
Endometrium	RL952	4.1
Endometrium	SNGM	4.9
Endometrium	SNU1077	5.1
Endometrium	SNU685	4.2
Endometrium	TEN	6.6
Haematopoietic and lymphoid	697	6.8
Haematopoietic and lymphoid	A3KAW	5
Haematopoietic and lymphoid	A4FUK	4.6
Haematopoietic and lymphoid	ALLSIL	4.3
Haematopoietic and lymphoid	AML193	4.3
Haematopoietic and lymphoid	AMO1	4.5
Haematopoietic and lymphoid	BCP1	4.2
Haematopoietic and lymphoid	BDCM	4.2
Haematopoietic and lymphoid	BL41	6.4
Haematopoietic and lymphoid	BL70	5.1
Haematopoietic and lymphoid	BV173	4.9
Haematopoietic and lymphoid	CA46	6
Haematopoietic and lymphoid	CI1	4.4
Haematopoietic and lymphoid	CMK115	4.2
Haematopoietic and lymphoid	CMK86	3.9
Haematopoietic and lymphoid	CMK	4.1
Haematopoietic and lymphoid	CMLT1	4
Haematopoietic and lymphoid	COLO775	4.1
Haematopoietic and lymphoid	DAUDI	5.1
Haematopoietic and lymphoid	DB	5
Haematopoietic and lymphoid	DEL	7
Haematopoietic and lymphoid	DND41	4.2
Haematopoietic and lymphoid	DOHH2	5.1
Haematopoietic and lymphoid	EB1	4.3
Haematopoietic and lymphoid	EB2	4.3
Haematopoietic and lymphoid	EHEB	4.8
Haematopoietic and lymphoid	EJM	4.5
Haematopoietic and lymphoid	EM2	3.9
Haematopoietic and lymphoid	EOL1	4.8
Haematopoietic and lymphoid	F36P	4
Haematopoietic and lymphoid	GA10	5.5
Haematopoietic and lymphoid	GDM1	4.2
Haematopoietic and lymphoid	GRANTA519	3.9
Haematopoietic and lymphoid	HDLM2	4.4
Haematopoietic and lymphoid	HDMYZ	5.2
Haematopoietic and lymphoid	HEL9217	4
Haematopoietic and lymphoid	HEL	4.1
Haematopoietic and lymphoid	HH	4.3
Haematopoietic and lymphoid	HL60	4.4
Haematopoietic and lymphoid	HPBALL	4.1
Haematopoietic and lymphoid	HS604T	5.2
Haematopoietic and lymphoid	HS611T	4.1
Haematopoietic and lymphoid	HS616T	4.7
Haematopoietic and lymphoid	HS751T	5.4
Haematopoietic and lymphoid	HT	4.3
Haematopoietic and lymphoid	HTK	4.5
Haematopoietic and lymphoid	HUNS1	4.4
Haematopoietic and lymphoid	HUT102	4.2
Haematopoietic and lymphoid	HUT78	4.4
Haematopoietic and lymphoid	JEKO1	5.9
Haematopoietic and lymphoid	JK1	4.5
Haematopoietic and lymphoid	JM1	5.3
Haematopoietic and lymphoid	JURKAT	4
Haematopoietic and lymphoid	JURLMK1	4.1
Haematopoietic and lymphoid	JVM2	4.6
Haematopoietic and lymphoid	JVM3	5.1
Haematopoietic and lymphoid	K562	4.1
Haematopoietic and lymphoid	KARPAS299	6.4
Haematopoietic and lymphoid	KARPAS422	4.4
Haematopoietic and lymphoid	KARPAS620	5
Haematopoietic and lymphoid	KASUMI1	4.5
Haematopoietic and lymphoid	KASUMI2	4.8
Haematopoietic and lymphoid	KASUMI6	4.3
Haematopoietic and lymphoid	KCL22	4.8
Haematopoietic and lymphoid	KE37	5.1
Haematopoietic and lymphoid	KE97	4.8
Haematopoietic and lymphoid	KG1	3.9
Haematopoietic and lymphoid	KHM1B	5.1
Haematopoietic and lymphoid	KIJK	5.3
Haematopoietic and lymphoid	KMH2	5
Haematopoietic and lymphoid	KMM1	4.7
Haematopoietic and lymphoid	KMS11	5.2
Haematopoietic and lymphoid	KMS12BM	4.2
Haematopoietic and lymphoid	KMS18	4.5
Haematopoietic and lymphoid	KMS20	4.2
Haematopoietic and lymphoid	KMS21BM	5.3
Haematopoietic and lymphoid	KMS26	4.8
Haematopoietic and lymphoid	KMS27	4.3
Haematopoietic and lymphoid	KMS28BM	5.1
Haematopoietic and lymphoid	KMS34	5.3
Haematopoietic and lymphoid	KO52	4.3
Haematopoietic and lymphoid	KOPN8	5.1
Haematopoietic and lymphoid	KU812	4.2
Haematopoietic and lymphoid	KYO1	4.2
Haematopoietic and lymphoid	L1236	4.5
Haematopoietic and lymphoid	L363	4.7
Haematopoietic and lymphoid	L428	4.3
Haematopoietic and lymphoid	L540	4.6
Haematopoietic and lymphoid	LAMA84	4.2
Haematopoietic and lymphoid	LOUCY	5.7
Haematopoietic and lymphoid	LP1	4.8
Haematopoietic and lymphoid	M07E	4.8
Haematopoietic and lymphoid	MC116	5.7
Haematopoietic and lymphoid	ME1	4.1
Haematopoietic and lymphoid	MEC1	4.8
Haematopoietic and lymphoid	MEC2	4.1
Haematopoietic and lymphoid	MEG01	4.3
Haematopoietic and lymphoid	MHHCALL2	5.4
Haematopoietic and lymphoid	MHHCALL3	5.9
Haematopoietic and lymphoid	MHHCALL4	4.6
Haematopoietic and lymphoid	MINO	5.4
Haematopoietic and lymphoid	MJ	4.3
Haematopoietic and lymphoid	MM1S	4.8
Haematopoietic and lymphoid	MOLM13	5.6
Haematopoietic and lymphoid	MOLM16	4.1
Haematopoietic and lymphoid	MOLM6	4.2
Haematopoietic and lymphoid	MOLP2	4.9
Haematopoietic and lymphoid	MOLP8	5.1
Haematopoietic and lymphoid	MOLT13	4.4
Haematopoietic and lymphoid	MOLT16	5.4
Haematopoietic and lymphoid	MOLT4	4.1
Haematopoietic and lymphoid	MONOMAC1	5.1
Haematopoietic and lymphoid	MONOMAC6	5.3
Haematopoietic and lymphoid	MOTN1	4.3
Haematopoietic and lymphoid	MUTZ5	4.1
Haematopoietic and lymphoid	MV411	4.3
Haematopoietic and lymphoid	NALM19	6.3
Haematopoietic and lymphoid	NALM1	5.3
Haematopoietic and lymphoid	NALM6	5.1
Haematopoietic and lymphoid	NAMALWA	4.7
Haematopoietic and lymphoid	NB4	4.5
Haematopoietic and lymphoid	NCIH929	4.7
Haematopoietic and lymphoid	NCO2	4.2
Haematopoietic and lymphoid	NOMO1	5.8
Haematopoietic and lymphoid	NUDHL1	5.3
Haematopoietic and lymphoid	NUDUL1	4.8
Haematopoietic and lymphoid	OCIAML2	4.9
Haematopoietic and lymphoid	OCIAML3	4.7
Haematopoietic and lymphoid	OCIAML5	5
Haematopoietic and lymphoid	OCILY10	4.4
Haematopoietic and lymphoid	OCILY19	4.7
Haematopoietic and lymphoid	OCILY3	4.3
Haematopoietic and lymphoid	OCIM1	4
Haematopoietic and lymphoid	OPM2	5.5
Haematopoietic and lymphoid	P12ICHIKAWA	4.4
Haematopoietic and lymphoid	P31FUJ	4.5
Haematopoietic and lymphoid	P3HR1	4.7
Haematopoietic and lymphoid	PCM6	4
Haematopoietic and lymphoid	PEER	4.2
Haematopoietic and lymphoid	PF382	4.4
Haematopoietic and lymphoid	PFEIFFER	4.4
Haematopoietic and lymphoid	PL21	4.9
Haematopoietic and lymphoid	RAJI	4.4
Haematopoietic and lymphoid	RCHACV	6.5
Haematopoietic and lymphoid	REC1	6.1
Haematopoietic and lymphoid	REH	4.6
Haematopoietic and lymphoid	RI1	6.1
Haematopoietic and lymphoid	RL	4.4
Haematopoietic and lymphoid	RPMI8226	4.9
Haematopoietic and lymphoid	RPMI8402	4.3
Haematopoietic and lymphoid	RS411	5.7
Haematopoietic and lymphoid	SEM	4.7
Haematopoietic and lymphoid	SET2	4.1
Haematopoietic and lymphoid	SIGM5	5.6
Haematopoietic and lymphoid	SKM1	4.6
Haematopoietic and lymphoid	SKMM2	5.4
Haematopoietic and lymphoid	SR786	4.4
Haematopoietic and lymphoid	ST486	5
Haematopoietic and lymphoid	SUDHL10	4.9
Haematopoietic and lymphoid	SUDHL1	5
Haematopoietic and lymphoid	SUDHL4	4.5
Haematopoietic and lymphoid	SUDHL5	4.8
Haematopoietic and lymphoid	SUDHL6	4.3
Haematopoietic and lymphoid	SUDHL8	4.4
Haematopoietic and lymphoid	SUPB15	5.7
Haematopoietic and lymphoid	SUPHD1	5.3
Haematopoietic and lymphoid	SUPM2	6
Haematopoietic and lymphoid	SUPT11	4.3
Haematopoietic and lymphoid	SUPT1	5.1
Haematopoietic and lymphoid	TALL1	5.1
Haematopoietic and lymphoid	TF1	4.3
Haematopoietic and lymphoid	THP1	6.2
Haematopoietic and lymphoid	TO175T	4.8
Haematopoietic and lymphoid	TOLEDO	4.7
Haematopoietic and lymphoid	U266B1	5.5
Haematopoietic and lymphoid	U937	4.1
Haematopoietic and lymphoid	UT7	3.9
Haematopoietic and lymphoid	WSUDLCL2	5.3
Kidney	769P	4.8
Kidney	786O	4.8
Kidney	A498	4.6
Kidney	A704	5.1
Kidney	ACHN	4.5
Kidney	BFTC909	4.6
Kidney	CAKI1	4.7
Kidney	CAKI2	4.8
Kidney	CAL54	5.3
Kidney	KMRC1	5
Kidney	KMRC20	4
Kidney	KMRC2	4.9
Kidney	KMRC3	4.4
Kidney	OSRC2	4.5
Kidney	RCC10RGB	4.5
Kidney	SNU1272	4.7
Kidney	SNU349	5.8
Kidney	TUHR10TKB	4.9
Kidney	TUHR14TKB	4.3
Kidney	TUHR4TKB	4.9
Kidney	VMRCRCW	4.6
Kidney	VMRCRCZ	4
Large intestine	C2BBE1	4.1
Large intestine	CCK81	4.2
Large intestine	CL11	4.7
Large intestine	CL14	4.2
Large intestine	CL34	3.9
Large intestine	CL40	4.3
Large intestine	COLO205	4.2
Large intestine	COLO320	4.8
Large intestine	COLO678	4.1
Large intestine	CW2	4.2
Large intestine	DLD1	4.1
Large intestine	GP2D	4.1
Large intestine	HCC56	4.1
Large intestine	HCT116	4
Large intestine	HCT15	4.2
Large intestine	HS675T	4.1
Large intestine	HS698T	4.9
Large intestine	HT115	4.9
Large intestine	HT29	4.3
Large intestine	HT55	4.2
Large intestine	KM12	4.3
Large intestine	LOVO	4.6
Large intestine	LS1034	4.3
Large intestine	LS123	4.6
Large intestine	LS180	3.9
Large intestine	LS411N	4
Large intestine	LS513	4.4
Large intestine	MDST8	6.7
Large intestine	NCIH508	4.2
Large intestine	NCIH716	4.3
Large intestine	NCIH747	5.2
Large intestine	OUMS23	4.2
Large intestine	RCM1	4.6
Large intestine	RKO	5.1
Large intestine	SKCO1	4.3
Large intestine	SNU1040	4.4
Large intestine	SNU1197	7.4
Large intestine	SNU175	4.4
Large intestine	SNU283	4.1
Large intestine	SNU407	4.3
Large intestine	SNU503	4.1
Large intestine	SNU61	4.5
Large intestine	SNU81	3.9
Large intestine	SNUC1	4.4
Large intestine	SNUC2A	4.1
Large intestine	SNUC4	4.1
Large intestine	SNUC5	4
Large intestine	SW1116	4.6
Large intestine	SW1417	4.5
Large intestine	SW1463	4.3
Large intestine	SW403	3.9
Large intestine	SW480	4.2
Large intestine	SW48	4
Large intestine	SW620	4.2
Large intestine	SW837	4.2
Large intestine	SW948	3.9
Large intestine	T84	4.5
Liver	ALEXANDERCELLS	4.4
Liver	C3A	4.2
Liver	HEP3B217	4.7
Liver	HEPG2	4.2
Liver	HLE	4.5
Liver	HLF	4.8
Liver	HUH1	4.4
Liver	HUH6	4.1
Liver	HUH7	4.1
Liver	JHH1	4.5
Liver	JHH2	4.5
Liver	JHH4	4.9
Liver	JHH5	4.2
Liver	JHH6	4.9
Liver	JHH7	4.2
Liver	LI7	5.2
Liver	PLCPRF5	4.5
Liver	SKHEP1	5
Liver	SNU182	4.3
Liver	SNU387	4.4
Liver	SNU398	8
Liver	SNU423	5.5
Liver	SNU449	4.8
Liver	SNU475	6.4
Liver	SNU761	6.1
Liver	SNU878	5.3
Liver	SNU886	4.5
Lung	A549	4.2
Lung	ABC1	4.4
Lung	BEN	4
Lung	CAL12T	4.3
Lung	CALU1	4.7
Lung	CALU3	7.3
Lung	CALU6	4.2
Lung	CHAGOK1	4.5
Lung	COLO668	4.5
Lung	COLO699	4.1
Lung	CORL105	3.9
Lung	CORL23	4.9
Lung	CORL24	5.8
Lung	CORL279	5.1
Lung	CORL311	5
Lung	CORL47	7.1
Lung	CORL51	4.8
Lung	CORL88	4.7
Lung	CORL95	6
Lung	CPCN	5.6
Lung	DMS114	4.3
Lung	DMS153	4.7
Lung	DMS273	6
Lung	DMS454	4.2
Lung	DMS53	4.1
Lung	DMS79	5.1
Lung	DV90	4.4
Lung	EBC1	5
Lung	EPLC272H	4.9
Lung	HARA	4
Lung	HCC1171	4.8
Lung	HCC1195	4.7
Lung	HCC15	4.2
Lung	HCC2279	4.7
Lung	HCC2935	4.6
Lung	HCC33	6.6
Lung	HCC366	5.2
Lung	HCC4006	4.5
Lung	HCC44	4.6
Lung	HCC78	4.9
Lung	HCC827	4.9
Lung	HCC95	5.2
Lung	HLC1	4.3
Lung	HLFA	4.1
Lung	HS229T	4.4
Lung	HS618T	4.2
Lung	IALM	4.1
Lung	KNS62	5.2
Lung	LC1F	4.3
Lung	LC1SQSF	4.4
Lung	LCLC103H	5.9
Lung	LCLC97TM1	5
Lung	LK2	4.5
Lung	LOUNH91	5.2
Lung	LU65	4.2
Lung	LU99	6
Lung	LUDLU1	4
Lung	LXF289	4.5
Lung	MORCPR	4.9
Lung	NCIH1048	7.5
Lung	NCIH1092	7.5
Lung	NCIH1105	4.5
Lung	NCIH1155	4.8
Lung	NCIH1184	6.8
Lung	NCIH1299	4.8
Lung	NCIH1339	5.3
Lung	NCIH1341	7.3
Lung	NCIH1355	4.1
Lung	NCIH1373	4.2
Lung	NCIH1385	4.2
Lung	NCIH1395	4.3
Lung	NCIH1435	4.3
Lung	NCIH1436	4.5
Lung	NCIH1437	4.2
Lung	NCIH146	6.4
Lung	NCIH1563	4.1
Lung	NCIH1568	4.1
Lung	NCIH1573	4.4
Lung	NCIH1581	9
Lung	NCIH1618	4.3
Lung	NCIH1623	4.2
Lung	NCIH1648	4.8
Lung	NCIH1650	4.5
Lung	NCIH1651	4.2
Lung	NCIH1666	4.1
Lung	NCIH1693	5
Lung	NCIH1694	4.1
Lung	NCIH1703	4.6
Lung	NCIH1734	4.2
Lung	NCIH1755	4.3
Lung	NCIH1781	4.9
Lung	NCIH1792	4.3
Lung	NCIH1793	4.4
Lung	NCIH1836	4.7
Lung	NCIH1838	5.4
Lung	NCIH1869	5
Lung	NCIH1876	4.5
Lung	NCIH1915	4.4
Lung	NCIH1930	5
Lung	NCIH1944	4.3
Lung	NCIH1963	5.2
Lung	NCIH196	5.5
Lung	NCIH1975	4.7
Lung	NCIH2009	4.4
Lung	NCIH2023	4.1
Lung	NCIH2029	4.6
Lung	NCIH2030	5.1
Lung	NCIH2066	4.4
Lung	NCIH2081	7.4
Lung	NCIH2085	4.8
Lung	NCIH2087	4.9
Lung	NCIH209	4
Lung	NCIH2106	4.8
Lung	NCIH2110	5.3
Lung	NCIH211	4.9
Lung	NCIH2122	4.2
Lung	NCIH2126	4.3
Lung	NCIH2141	4.7
Lung	NCIH2170	4.5
Lung	NCIH2171	4.5
Lung	NCIH2172	4.4
Lung	NCIH2196	4.4
Lung	NCIH2227	4.5
Lung	NCIH2228	4.2
Lung	NCIH226	5.3
Lung	NCIH2286	4.1
Lung	NCIH2291	5.3
Lung	NCIH2342	4.2
Lung	NCIH2347	4.9
Lung	NCIH23	4.2
Lung	NCIH2405	4.1
Lung	NCIH2444	6.9
Lung	NCIH292	4.3
Lung	NCIH322	4.9
Lung	NCIH3255	4.5
Lung	NCIH358	4.6
Lung	NCIH441	4.3
Lung	NCIH446	6
Lung	NCIH460	4.3
Lung	NCIH510	4
Lung	NCIH520	4.7
Lung	NCIH522	7.1
Lung	NCIH524	4
Lung	NCIH526	4.1
Lung	NCIH596	5.4
Lung	NCIH647	4.2
Lung	NCIH650	4.6
Lung	NCIH661	6.1
Lung	NCIH69	6.4
Lung	NCIH727	4.2
Lung	NCIH810	4.9
Lung	NCIH82	5
Lung	NCIH838	4.3
Lung	NCIH841	6
Lung	NCIH854	5.3
Lung	NCIH889	6.6
Lung	PC14	4.6
Lung	RERFLCAD1	4.4
Lung	RERFLCAD2	4.9
Lung	RERFLCAI	4.6
Lung	RERFLCKJ	4.3
Lung	RERFLCMS	4.4
Lung	RERFLCSQ1	4.4
Lung	SBC5	7.1
Lung	SCLC21H	5.1
Lung	SHP77	5.7
Lung	SKLU1	5.5
Lung	SKMES1	6.3
Lung	SQ1	5.1
Lung	SW1271	5
Lung	SW1573	4.3
Lung	SW900	5.3
Lung	VMRCLCD	4.9
Lung	VMRCLCP	4.6
Oesophagus	COLO680N	4.5
Oesophagus	ECGI10	4.9
Oesophagus	KYSE140	5.5
Oesophagus	KYSE150	4.4
Oesophagus	KYSE180	4.6
Oesophagus	KYSE270	4.3
Oesophagus	KYSE30	4.3
Oesophagus	KYSE410	4.2
Oesophagus	KYSE450	5
Oesophagus	KYSE510	4.5
Oesophagus	KYSE520	4.4
Oesophagus	KYSE70	4.4
Oesophagus	OE19	4.3
Oesophagus	OE33	4.8
Oesophagus	TE10	5.8
Oesophagus	TE11	5
Oesophagus	TE14	4.6
Oesophagus	TE15	5.7
Oesophagus	TE1	4.8
Oesophagus	TE4	4.1
Oesophagus	TE5	4.7
Oesophagus	TE6	5.3
Oesophagus	TE8	3.9
Oesophagus	TE9	4.6
Oesophagus	TT	4
Ovary	59M	4.2
Ovary	A2780	5.4
Ovary	CAOV3	4.1
Ovary	CAOV4	6.3
Ovary	COLO704	5.3
Ovary	COV318	5.7
Ovary	COV362	6
Ovary	COV434	7.9
Ovary	COV504	5.5
Ovary	COV644	4.5
Ovary	EFO21	7
Ovary	EFO27	4.1
Ovary	ES2	4.7
Ovary	FUOV1	4.5
Ovary	HEYA8	4.6
Ovary	HS571T	5.2
Ovary	IGROV1	5.5
Ovary	JHOC5	6.5
Ovary	JHOM1	4.6
Ovary	JHOM2B	5.4
Ovary	JHOS2	5.2
Ovary	JHOS4	5.2
Ovary	KURAMOCHI	5
Ovary	MCAS	5.3
Ovary	NIHOVCAR3	5.1
Ovary	OAW28	4.3
Ovary	OAW42	4.6
Ovary	OC314	4.5
Ovary	OC316	4.3
Ovary	ONCODG1	4.8
Ovary	OV56	5
Ovary	OV7	4.3
Ovary	OV90	4.6
Ovary	OVCAR4	5.8
Ovary	OVCAR8	4.5
Ovary	OVISE	5.1
Ovary	OVK18	4.2
Ovary	OVKATE	4.7
Ovary	OVMANA	5.9
Ovary	OVSAHO	4.9
Ovary	OVTOKO	4.8
Ovary	RMGI	4.7
Ovary	RMUGS	4.2
Ovary	SKOV3	4.2
Ovary	SNU119	6.8
Ovary	SNU840	4.1
Ovary	SNU8	7.2
Ovary	TOV112D	10.6
Ovary	TOV21G	4.4
Ovary	TYKNU	6.1
Pancreas	ASPC1	5
Pancreas	BXPC3	4.4
Pancreas	CAPAN1	5.3
Pancreas	CAPAN2	4.8
Pancreas	CFPAC1	4.8
Pancreas	DANG	5.1
Pancreas	HPAC	5.4
Pancreas	HPAFII	5.1
Pancreas	HS766T	5.2
Pancreas	HUPT3	5.7
Pancreas	HUPT4	5
Pancreas	KCIMOH1	5.6
Pancreas	KLM1	4.6
Pancreas	KP2	5.5
Pancreas	KP3	5.2
Pancreas	KP4	4.2
Pancreas	L33	4.3
Pancreas	MIAPACA2	5.8
Pancreas	PANC0203	4.8
Pancreas	PANC0213	6.3
Pancreas	PANC0327	4.4
Pancreas	PANC0403	4.7
Pancreas	PANC0504	5.2
Pancreas	PANC0813	5.1
Pancreas	PANC1005	4.7
Pancreas	PANC1	4.7
Pancreas	PATU8902	4.5
Pancreas	PATU8988S	4.3
Pancreas	PATU8988T	4.8
Pancreas	PK1	4.4
Pancreas	PK45H	6
Pancreas	PK59	4.5
Pancreas	PL45	4.7
Pancreas	PSN1	3.8
Pancreas	QGP1	4.8
Pancreas	SNU213	6.6
Pancreas	SNU324	4.3
Pancreas	SNU410	5
Pancreas	SU8686	6.2
Pancreas	SUIT2	4.3
Pancreas	SW1990	5.5
Pancreas	T3M4	5.3
Pancreas	TCCPAN2	4.2
Pancreas	YAPC	6.1
Pleura	ACCMESO1	4.6
Pleura	DM3	4.9
Pleura	ISTMES1	4.5
Pleura	ISTMES2	4.7
Pleura	JL1	4.7
Pleura	MPP89	4.5
Pleura	MSTO211H	5.2
Pleura	NCIH2052	4.9
Pleura	NCIH2452	5.3
Pleura	NCIH28	4.2
Prostate	22RV1	4
Prostate	DU145	4.1
Prostate	LNCAPCLONEFGC	4.1
Prostate	MDAPCA2B	4.2
Prostate	NCIH660	5.1
Prostate	PC3	4.3
Prostate	VCAP	4.2
Salivary gland	A253	4.5
Salivary gland	YD15	4.8
Skin	A101D	5
Skin	A2058	4.1
Skin	A375	5
Skin	C32	5.3
Skin	CHL1	4
Skin	CJM	6
Skin	COLO679	4.6
Skin	COLO741	4.3
Skin	COLO783	4.6
Skin	COLO792	4.5
Skin	COLO800	5.2
Skin	COLO818	5.4
Skin	COLO829	4.7
Skin	COLO849	4.6
Skin	G361	4.6
Skin	GRM	4.1
Skin	HMCB	4.2
Skin	HS294T	4.5
Skin	HS600T	4.7
Skin	HS688AT	4.8
Skin	HS695T	4.2
Skin	HS839T	4.2
Skin	HS852T	6.1
Skin	HS895T	4.4
Skin	HS934T	4.6
Skin	HS936T	4.2
Skin	HS939T	5.3
Skin	HS940T	5.3
Skin	HS944T	5.1
Skin	HT144	4.4
Skin	IGR1	4.8
Skin	IGR37	4.3
Skin	IGR39	4.9
Skin	IPC298	5.2
Skin	K029AX	4.2
Skin	LOXIMVI	5.3
Skin	MALME3M	4.4
Skin	MDAMB435S	5.9
Skin	MELHO	4.8
Skin	MELJUSO	5.6
Skin	MEWO	4.7
Skin	RPMI7951	4.8
Skin	RVH421	5.2
Skin	SH4	5.1
Skin	SKMEL1	4.8
Skin	SKMEL24	5.4
Skin	SKMEL28	5
Skin	SKMEL2	5.7
Skin	SKMEL30	4.7
Skin	SKMEL31	5.6
Skin	SKMEL3	4.6
Skin	SKMEL5	4.4
Skin	UACC257	4.7
Skin	UACC62	4.9
Skin	WM115	6.7
Skin	WM1799	5.2
Skin	WM2664	4.1
Skin	WM793	7.3
Skin	WM88	4.8
Skin	WM983B	5.6
Small intestine	HUTU80	5.5
Soft tissue	A204	4.3
Soft tissue	G401	4.2
Soft tissue	G402	4.3
Soft tissue	GCT	5.4
Soft tissue	HS729	4.4
Soft tissue	HT1080	4.5
Soft tissue	KYM1	4.3
Soft tissue	MESSA	4.2
Soft tissue	RD	4.3
Soft tissue	RH30	4.1
Soft tissue	RH41	4
Soft tissue	RKN	4.9
Soft tissue	S117	5.8
Soft tissue	SJRH30	4.2
Soft tissue	SKLMS1	4.3
Soft tissue	SKUT1	7.2
Soft tissue	TE125T	5.6
Soft tissue	TE159T	4.5
Soft tissue	TE441T	4.3
Soft tissue	TE617T	4.2
Stomach	2313287	4.1
Stomach	AGS	4.2
Stomach	AZ521	5.5
Stomach	ECC10	9.3
Stomach	ECC12	5
Stomach	FU97	4.4
Stomach	GCIY	4.7
Stomach	GSS	7.5
Stomach	GSU	3.9
Stomach	HGC27	6.2
Stomach	HS746T	5
Stomach	HUG1N	5.7
Stomach	IM95	4.5
Stomach	KATOIII	5
Stomach	KE39	4.5
Stomach	LMSU	5.4
Stomach	MKN1	4.1
Stomach	MKN45	4.1
Stomach	MKN74	5.3
Stomach	MKN7	4.8
Stomach	NCCSTCK140	3.8
Stomach	NCIN87	4.3
Stomach	NUGC2	4.7
Stomach	NUGC3	4.5
Stomach	NUGC4	4.2
Stomach	OCUM1	4.6
Stomach	RERFGC1B	4.2
Stomach	SH10TC	4.3
Stomach	SNU16	4.2
Stomach	SNU1	6.1
Stomach	SNU216	5.3
Stomach	SNU520	4.1
Stomach	SNU5	4.6
Stomach	SNU601	4.4
Stomach	SNU620	4.2
Stomach	SNU668	4
Stomach	SNU719	4.3
Stomach	TGBC11TKB	4.2
Thyroid	8305C	4.5
Thyroid	8505C	4.4
Thyroid	BCPAP	4.5
Thyroid	BHT101	6
Thyroid	CAL62	4.1
Thyroid	CGTHW1	5.1
Thyroid	FTC133	4.7
Thyroid	FTC238	4.6
Thyroid	ML1	4.1
Thyroid	SW579	4.3
Thyroid	TT2609C02	4.5
Thyroid	TT	5.2
Upper aerodigestive tract	BHY	5.5
Upper aerodigestive tract	BICR16	4.8
Upper aerodigestive tract	BICR18	4.5
Upper aerodigestive tract	BICR22	4.7
Upper aerodigestive tract	BICR31	5.1
Upper aerodigestive tract	BICR56	5.5
Upper aerodigestive tract	BICR6	4.6
Upper aerodigestive tract	CAL27	5
Upper aerodigestive tract	CAL33	5.6
Upper aerodigestive tract	DETROIT562	5.2
Upper aerodigestive tract	FADU	4.1
Upper aerodigestive tract	HS840T	4.4
Upper aerodigestive tract	HSC2	4.7
Upper aerodigestive tract	HSC3	5
Upper aerodigestive tract	HSC4	4.5
Upper aerodigestive tract	PECAPJ15	4.7
Upper aerodigestive tract	PECAPJ34CLONEC12	5
Upper aerodigestive tract	PECAPJ41CLONED2	5.5
Upper aerodigestive tract	PECAPJ49	4.8
Upper aerodigestive tract	SCC15	5.8
Upper aerodigestive tract	SCC25	4.7
Upper aerodigestive tract	SCC4	5.2
Upper aerodigestive tract	SCC9	4.3
Upper aerodigestive tract	SNU1076	5.5
Upper aerodigestive tract	SNU1214	4
Upper aerodigestive tract	SNU46	4
Upper aerodigestive tract	SNU899	5.5
Upper aerodigestive tract	YD10B	4.2
Upper aerodigestive tract	YD38	5
Upper aerodigestive tract	YD8	5.1
Urinary tract	5637	5.5
Urinary tract	639V	4.3
Urinary tract	647V	4.7
Urinary tract	BC3C	4.7
Urinary tract	BFTC905	4.5
Urinary tract	CAL29	4.3
Urinary tract	HS172T	4.4
Urinary tract	HT1197	4.8
Urinary tract	HT1376	4.3
Urinary tract	J82	4.2
Urinary tract	JMSU1	5.2
Urinary tract	KMBC2	4.9
Urinary tract	KU1919	4.2
Urinary tract	RT11284	4.2
Urinary tract	RT112	4.1
Urinary tract	RT4	4.8
Urinary tract	SCABER	5
Urinary tract	SW1710	4
Urinary tract	SW780	4.1
Urinary tract	T24	4.2
Urinary tract	TCCSUP	4.4
Urinary tract	UMUC1	4.2
Urinary tract	UMUC3	4.4
Urinary tract	VMCUB1	4.4

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	9.2
Adrenal gland	16.4
Appendix	12.3
Bone marrow	4.1
Breast	3.8
Cerebral cortex	23.9
Cervix, uterine	15.4
Colon	5.5
Duodenum	3.6
Endometrium	22.5
Epididymis	7.2
Esophagus	3.3
Fallopian tube	15.5
Gallbladder	11
Heart muscle	9.5
Kidney	3
Liver	1.5
Lung	8
Lymph node	23.6
Ovary	3
Pancreas	0.3
Parathyroid gland	4.1
Placenta	9.3
Prostate	18.2
Rectum	6.4
Salivary gland	2.9
Seminal vesicle	20.4
Skeletal muscle	5.8
Skin	2.6
Small intestine	4.3
Smooth muscle	19.7
Spleen	25
Stomach	8.4
Testis	10.9
Thyroid gland	5
Tonsil	18.4
Urinary bladder	8.2

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27033599	Overexpression	Retinoblastoma	In this study, we found that HDAC9 was commonly expressed in retinoblastoma tissues and HDAC9 was overexpressed in prognostically poor retinoblastoma patients.
25760078	Overexpression	Glioblastoma	We found that HDAC9 is over-expressed in prognostically poor glioblastoma patients.
24913006	Overexpression	Rhabdoid cancer	In primary BRM-deficient Rhabdoid tumors, HDAC9 was also found to be highly overexpressed.
20413433	Overexpression	Medulloblastoma	HDAC5 and HDAC9 are significantly upregulated in high-risk medulloblastoma in comparison with low-risk medulloblastoma, and their expression is associated with poor survival.
27993968	Overexpression	Lymphoma	GEP revealed upregulation of MAPK10, HELIOS, HDAC9, and FYN, as well as downregulation of SH3BP5 and LCK.
28419090	Overexpression	Leiomyosarcoma	Class IIa HDACs are overexpressed in 22% of LMS, where high levels of MEF2, HDAC4 and HDAC9 inversely correlate with overall survival.

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.068	0.175	5	47.8	47.3	Gain
BRCA	Breast invasive carcinoma	1075	0.072	0.0175	11.5	56.1	32.4	Neutral
CESC	Cervical and endocervical cancers	292	-0.022	0.712	9.6	75.7	14.7	Neutral
COAD	Colon adenocarcinoma	449	0.043	0.362	0.7	43	56.3	Gain
ESCA	Esophageal carcinoma	183	0.161	0.0297	7.7	25.1	67.2	Gain
GBM	Glioblastoma multiforme	147	0.366	5.25e-06	2	19	78.9	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.155	0.000432	5.1	56.6	38.3	Gain
KIRC	Kidney renal clear cell carcinoma	525	-0.027	0.543	0.6	67	32.4	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.417	1.59e-13	0.7	39.2	60.1	Gain
LAML	Acute Myeloid Leukemia	166	0.085	0.273	10.2	89.2	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.183	3.08e-05	1.4	75.8	22.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	-0.084	0.11	4.7	62.6	32.7	Neutral
LUAD	Lung adenocarcinoma	512	0.157	0.000369	5.5	40.2	54.3	Gain
LUSC	Lung squamous cell carcinoma	498	0.066	0.141	12.4	36.1	51.4	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.291	2.91e-07	37.3	33	29.7	Loss
PAAD	Pancreatic adenocarcinoma	177	-0.157	0.037	1.1	70.6	28.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.185	0.0183	1.9	80.9	17.3	Neutral
PRAD	Prostate adenocarcinoma	491	-0.039	0.394	2.6	76.2	21.2	Neutral
READ	Rectum adenocarcinoma	164	0.035	0.653	0.6	36	63.4	Gain
SARC	Sarcoma	255	-0.021	0.737	11.8	52.2	36.1	Gain
SKCM	Skin Cutaneous Melanoma	367	0.071	0.175	4.9	38.1	56.9	Gain
STAD	Stomach adenocarcinoma	413	0.008	0.872	4.8	46	49.2	Gain
TGCT	Testicular Germ Cell Tumors	150	0.09	0.271	1.3	15.3	83.3	Gain
THCA	Thyroid carcinoma	497	-0.163	0.000262	0.2	96.2	3.6	Neutral
THYM	Thymoma	119	0.281	0.00197	1.7	86.6	11.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.177	3.64e-05	10.4	74.5	15.1	Neutral

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.223	3.59e-06	17	408	0.174	0.00459	NS/NA
BRCA	Breast invasive carcinoma	-0.354	0	83	785	0.248	2e-45	Increased
CESC	Cervical and endocervical cancers	-0.352	2.53e-10	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.404	8.05e-14	19	297	0.055	0.000281	NS/NA
ESCA	Esophageal carcinoma	-0.132	0.0676	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.502	2.69e-05	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.088	0.0411	20	522	0.001	3.52e-07	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.067	0.215	24	319	0.1	0.0107	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.255	9.13e-06	23	275	0.004	5.79e-05	NS/NA
LAML	Acute Myeloid Leukemia	-0.451	9.78e-10	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.349	1.45e-16	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	0.113	0.0215	41	373	-0.111	7.3e-19	NS/NA
LUAD	Lung adenocarcinoma	-0.186	4.35e-05	21	456	0.015	0.955	NS/NA
LUSC	Lung squamous cell carcinoma	-0.135	0.00867	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.5	0.178	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.432	1.45e-09	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.246	0.000727	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.738	0	35	498	0.32	8.15e-18	Increased
READ	Rectum adenocarcinoma	-0.333	0.000709	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.505	0	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.147	0.00141	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.2	0.00011	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.763	0	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.172	4.51e-05	50	509	-0.235	1.6e-50	Decreased
THYM	Thymoma	-0.706	0	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.279	1.05e-09	34	431	0.101	2.36e-15	NS/NA

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	2	Medium
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	1	Low
Cerebellum	2	Medium
Cerebral cortex	2	Medium
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	1	Low
Hippocampus	0	Not detected
Kidney	3	High
Liver	2	Medium
Lung	2	Medium
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	0	Not detected
Placenta	3	High
Prostate	2	Medium
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	2	Medium
Spleen	1	Low
Stomach	2	Medium
Testis	3	High
Thyroid gland	1	Low
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.223	NS	24476821
BRCA	Breast invasive carcinoma	521	1.93e-05	Significant	23000897
COAD	Colon adenocarcinoma	149	0.296	NS	22810696
GBM	Glioblastoma multiforme	157	0.232	NS	26824661
HNSC	Head and Neck squamous cell carcinoma	279	7.91e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.00459	Significant	26536169
LGG	Brain Lower Grade Glioma	513	2.1e-19	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.69e-10	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000151	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.075	NS	21720365
PRAD	Prostate adenocarcinoma	333	4.16e-13	Significant	26544944
READ	Rectum adenocarcinoma	67	0.427	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.00372	Significant	26091043
STAD	Stomach adenocarcinoma	277	7.59e-07	Significant	25079317
THCA	Thyroid carcinoma	391	0.00188	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0133	Significant	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.456	0.0977	NS
BRCA	Breast invasive carcinoma	1079	0.757	0.246	NS
CESC	Cervical and endocervical cancers	291	1.119	0.739	NS
COAD	Colon adenocarcinoma	439	1.121	0.695	NS
ESCA	Esophageal carcinoma	184	1.119	0.712	NS
GBM	Glioblastoma multiforme	158	0.918	0.743	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.383	0.0926	NS
KIRC	Kidney renal clear cell carcinoma	531	0.691	0.0799	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.005	0.991	NS
LAML	Acute Myeloid Leukemia	149	1.362	0.332	NS
LGG	Brain Lower Grade Glioma	511	1.436	0.201	NS
LIHC	Liver hepatocellular carcinoma	365	1.052	0.832	NS
LUAD	Lung adenocarcinoma	502	0.895	0.583	NS
LUSC	Lung squamous cell carcinoma	494	1.289	0.196	NS
OV	Ovarian serous cystadenocarcinoma	303	0.715	0.125	NS
PAAD	Pancreatic adenocarcinoma	177	1.154	0.615	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.0717	NS
PRAD	Prostate adenocarcinoma	497	0	0.0598	NS
READ	Rectum adenocarcinoma	159	0.824	0.728	NS
SARC	Sarcoma	259	0.841	0.556	NS
SKCM	Skin Cutaneous Melanoma	459	0.851	0.399	NS
STAD	Stomach adenocarcinoma	388	1.005	0.983	NS
TGCT	Testicular Germ Cell Tumors	134	1.116	0.938	NS
THCA	Thyroid carcinoma	500	0.732	0.669	NS
THYM	Thymoma	119	1678602847.704	0.0154	Shorter
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.698	0.211	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.046	0.357	NS
BRCA	Breast invasive carcinoma	1071	0.005	0.859	NS
CESC	Cervical and endocervical cancers	167	-0.073	0.346	NS
COAD	Colon adenocarcinoma	445	0.098	0.0386	Higher
ESCA	Esophageal carcinoma	162	0.022	0.781	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.023	0.626	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.029	0.503	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.116	0.0614	NS
LIHC	Liver hepatocellular carcinoma	347	0	0.995	NS
LUAD	Lung adenocarcinoma	507	-0.078	0.0792	NS
LUSC	Lung squamous cell carcinoma	497	-0.097	0.03	Lower
OV	Ovarian serous cystadenocarcinoma	302	-0.084	0.147	NS
PAAD	Pancreatic adenocarcinoma	176	0.101	0.183	NS
READ	Rectum adenocarcinoma	156	0.008	0.917	NS
SKCM	Skin Cutaneous Melanoma	410	-0.011	0.817	NS
STAD	Stomach adenocarcinoma	392	0.094	0.0633	NS
TGCT	Testicular Germ Cell Tumors	81	-0.364	0.000835	Lower
THCA	Thyroid carcinoma	499	-0.084	0.0602	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.078	0.08	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.079	0.193	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.058	0.198	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.036	0.41	NS
LGG	Brain Lower Grade Glioma	514	0.06	0.175	NS
LIHC	Liver hepatocellular carcinoma	366	-0.012	0.816	NS
OV	Ovarian serous cystadenocarcinoma	296	0.008	0.896	NS
PAAD	Pancreatic adenocarcinoma	176	0.103	0.176	NS
STAD	Stomach adenocarcinoma	406	0.179	0.000297	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.112	0.00976	Lower

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB00313	Valproic Acid	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug
DB00313	Valproic Acid	Small Molecule Drug
DB05015	Belinostat	Small Molecule Drug
DB06603	Panobinostat	Small Molecule Drug

Summary
Symbol	HDAC9
Name	histone deacetylase 9
Aliases	KIAA0744; HDAC; MITR; HDAC7B; HD7b; HD9; HDAC7BB; HDAC9FL; HDRP; MEF-2 interacting transcription repressor ( ......
Location	7p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for HDAC9.