Browse HDGFL1 in pancancer

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

Domain

PF00855 PWWP domain

Function

-

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	-
Molecular Function	-
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3921138	c.594C>T	p.L198L	Substitution - coding silent	Skin
COSM3761723	c.260C>T	p.T87M	Substitution - Missense	Large_intestine
COSM1442449	c.273C>T	p.S91S	Substitution - coding silent	Skin
COSM4638623	c.279C>T	p.C93C	Substitution - coding silent	Large_intestine
COSM4960473	c.673C>T	p.R225W	Substitution - Missense	Liver
COSM1209431	c.199G>A	p.G67S	Substitution - Missense	Large_intestine
COSM5422011	c.495C>A	p.P165P	Substitution - coding silent	Prostate
COSM5492010	c.5C>T	p.S2L	Substitution - Missense	Biliary_tract
COSM5785912	c.157C>A	p.P53T	Substitution - Missense	Breast
COSM5785816	c.586C>G	p.P196A	Substitution - Missense	Breast
COSM1442452	c.372C>T	p.G124G	Substitution - coding silent	Large_intestine
COSM1442452	c.372C>T	p.G124G	Substitution - coding silent	Large_intestine
COSM5346082	c.80C>T	p.A27V	Substitution - Missense	Soft_tissue
COSM3623164	c.246C>T	p.I82I	Substitution - coding silent	Skin
COSM2856507	c.129C>T	p.F43F	Substitution - coding silent	Large_intestine
COSM741017	c.14G>T	p.G5V	Substitution - Missense	Lung
COSM1621249	c.739G>T	p.D247Y	Substitution - Missense	Liver
COSM5476666	c.334G>C	p.A112P	Substitution - Missense	Large_intestine
COSM5460143	c.624C>T	p.S208S	Substitution - coding silent	Large_intestine
COSM4689742	c.537G>A	p.A179A	Substitution - coding silent	Large_intestine
COSM1076449	c.103C>T	p.P35S	Substitution - Missense	Endometrium
COSM3948829	c.154A>T	p.S52C	Substitution - Missense	Lung
COSM4639555	c.556G>A	p.A186T	Substitution - Missense	Large_intestine
COSM3761723	c.260C>T	p.T87M	Substitution - Missense	Thyroid
COSM295331	c.694G>T	p.E232*	Substitution - Nonsense	Large_intestine
COSM297508	c.45G>A	p.V15V	Substitution - coding silent	Large_intestine
COSM4940394	c.382G>A	p.E128K	Substitution - Missense	Liver
COSM311731	c.250A>G	p.N84D	Substitution - Missense	Lung
COSM5461480	c.566C>T	p.T189M	Substitution - Missense	Large_intestine
COSM3719699	c.227G>A	p.S76N	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM3623163	c.241G>A	p.E81K	Substitution - Missense	Skin
COSM3921137	c.519G>A	p.A173A	Substitution - coding silent	Skin
COSM1442449	c.273C>T	p.S91S	Substitution - coding silent	Large_intestine
COSM4831495	c.403G>T	p.D135Y	Substitution - Missense	Cervix
COSM4586502	c.148T>C	p.F50L	Substitution - Missense	Bone
COSM4494366	c.431C>T	p.P144L	Substitution - Missense	Skin
COSM5952762	c.195G>T	p.K65N	Substitution - Missense	Oesophagus
COSM5623271	c.548C>G	p.A183G	Substitution - Missense	Oesophagus
COSM1442451	c.342C>T	p.G114G	Substitution - coding silent	Large_intestine
COSM4798861	c.5C>A	p.S2*	Substitution - Nonsense	Liver
COSM1442453	c.377G>A	p.G126D	Substitution - Missense	Large_intestine
COSM4160411	c.385T>C	p.L129L	Substitution - coding silent	Thyroid
COSM3393996	c.130G>A	p.G44R	Substitution - Missense	Pancreas
COSM4689744	c.551C>T	p.A184V	Substitution - Missense	Large_intestine
COSM3623161	c.132G>A	p.G44G	Substitution - coding silent	Skin
COSM5683813	c.410C>A	p.P137H	Substitution - Missense	Soft_tissue
COSM4643076	c.444C>T	p.S148S	Substitution - coding silent	Large_intestine
COSM1442448	c.78G>A	p.P26P	Substitution - coding silent	Large_intestine
COSM5357635	c.163C>T	p.R55C	Substitution - Missense	Large_intestine
COSM4501361	c.586C>T	p.P196S	Substitution - Missense	Skin
COSM1721241	c.663_664GG>AA	p.E222K	Substitution - Missense	Skin
COSM183222	c.198C>T	p.F66F	Substitution - coding silent	Endometrium
COSM1442451	c.342C>T	p.G114G	Substitution - coding silent	Large_intestine
COSM5720544	c.682G>A	p.E228K	Substitution - Missense	Skin
COSM3747658	c.565A>G	p.T189A	Substitution - Missense	Liver
COSM3623167	c.694G>A	p.E232K	Substitution - Missense	Skin
COSM1209430	c.458C>T	p.P153L	Substitution - Missense	Large_intestine
COSM5669739	c.96G>T	p.M32I	Substitution - Missense	Soft_tissue
COSM2856505	c.113A>G	p.Y38C	Substitution - Missense	Stomach
COSM3747658	c.565A>G	p.T189A	Substitution - Missense	Biliary_tract
COSM1076450	c.126C>A	p.F42L	Substitution - Missense	Endometrium
COSM311731	c.250A>G	p.N84D	Substitution - Missense	Lung
COSM2856511	c.230C>A	p.A77E	Substitution - Missense	Oesophagus
COSM3697700	c.688G>A	p.A230T	Substitution - Missense	Large_intestine
COSM1442450	c.321G>A	p.P107P	Substitution - coding silent	Large_intestine
COSM1076447	c.32G>A	p.S11N	Substitution - Missense	Endometrium
COSM4689741	c.318_323delGCCGGA	p.P109_E110delPE	Deletion - In frame	Large_intestine
COSM1442452	c.372C>T	p.G124G	Substitution - coding silent	Large_intestine
COSM3623164	c.246C>T	p.I82I	Substitution - coding silent	Skin
COSM1076448	c.86T>C	p.I29T	Substitution - Missense	Endometrium
COSM4632979	c.528G>A	p.A176A	Substitution - coding silent	Large_intestine
COSM2856515	c.290C>T	p.S97L	Substitution - Missense	Breast
COSM5357635	c.163C>T	p.R55C	Substitution - Missense	Large_intestine
COSM5551575	c.402C>T	p.D134D	Substitution - coding silent	Prostate
COSM1621249	c.739G>T	p.D247Y	Substitution - Missense	Liver
COSM1209432	c.217C>T	p.R73C	Substitution - Missense	Stomach
COSM4689743	c.542_543insGGC	p.A188_T189insA	Insertion - In frame	Large_intestine
COSM3623165	c.265C>T	p.Q89*	Substitution - Nonsense	Skin
COSM3948830	c.199G>T	p.G67C	Substitution - Missense	Lung
COSM1209432	c.217C>T	p.R73C	Substitution - Missense	Large_intestine
COSM1442452	c.372C>T	p.G124G	Substitution - coding silent	Large_intestine
COSM1442455	c.465C>T	p.D155D	Substitution - coding silent	Large_intestine
COSM5720544	c.682G>A	p.E228K	Substitution - Missense	Skin
COSM5479470	c.693C>T	p.D231D	Substitution - coding silent	Large_intestine
COSM3745078	c.415G>A	p.E139K	Substitution - Missense	Liver
COSM1642956	c.125T>A	p.F42Y	Substitution - Missense	Stomach
COSM5357317	c.609C>T	p.N203N	Substitution - coding silent	Large_intestine
COSM5404885	c.126C>T	p.F42F	Substitution - coding silent	Skin
COSM1442452	c.372C>T	p.G124G	Substitution - coding silent	Large_intestine
COSM5701142	c.471_472insT	p.K158fs*1	Insertion - Frameshift	Soft_tissue
COSM4547659	c.428G>A	p.G143E	Substitution - Missense	Skin
COSM4798861	c.5C>A	p.S2*	Substitution - Nonsense	Liver
COSM483732	c.61G>T	p.G21C	Substitution - Missense	Kidney
COSM1209433	c.446C>T	p.A149V	Substitution - Missense	Large_intestine
COSM1621249	c.739G>T	p.D247Y	Substitution - Missense	Liver
COSM5357317	c.609C>T	p.N203N	Substitution - coding silent	Large_intestine
COSM4881850	c.334G>T	p.A112S	Substitution - Missense	Upper_aerodigestive_tract
COSM5720544	c.682G>A	p.E228K	Substitution - Missense	Skin
COSM6012206	c.83G>A	p.R28K	Substitution - Missense	Skin
COSM1209431	c.199G>A	p.G67S	Substitution - Missense	Large_intestine
COSM3393996	c.130G>A	p.G44R	Substitution - Missense	Pancreas
COSM5737495	c.91C>T	p.H31Y	Substitution - Missense	Small_intestine
COSM4689745	c.643G>A	p.E215K	Substitution - Missense	Large_intestine
COSM4960473	c.673C>T	p.R225W	Substitution - Missense	Liver
COSM1076451	c.355C>T	p.P119S	Substitution - Missense	Endometrium
COSM4557872	c.745G>A	p.D249N	Substitution - Missense	Skin
COSM1442454	c.408G>A	p.K136K	Substitution - coding silent	Large_intestine
COSM1209432	c.217C>T	p.R73C	Substitution - Missense	Large_intestine
COSM4602070	c.350A>T	p.D117V	Substitution - Missense	Upper_aerodigestive_tract
COSM3860708	c.29A>T	p.K10M	Substitution - Missense	Stomach
COSM4560598	c.84G>A	p.R28R	Substitution - coding silent	Skin
COSM3623162	c.189G>A	p.K63K	Substitution - coding silent	Skin
COSM382395	c.265C>A	p.Q89K	Substitution - Missense	Lung
COSM183222	c.198C>T	p.F66F	Substitution - coding silent	Stomach
COSM5720544	c.682G>A	p.E228K	Substitution - Missense	Skin
COSM3393997	c.363C>T	p.H121H	Substitution - coding silent	Pancreas
COSM3623166	c.675G>A	p.R225R	Substitution - coding silent	Skin
COSM4160412	c.516G>A	p.E172E	Substitution - coding silent	Thyroid

> Text Mining based Variations [ TOP ]
There is no record for HDGFL1.

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
TGCT	Testicular Germ Cell Tumors	0	156	NA	2.905	NA	NA	NA

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

Tissue	Expression Level (TPM)
Adipose tissue	0
Adrenal gland	0
Appendix	0
Bone marrow	0
Breast	0
Cerebral cortex	0
Cervix, uterine	0
Colon	0
Duodenum	0
Endometrium	0
Epididymis	0
Esophagus	0
Fallopian tube	0
Gallbladder	0
Heart muscle	0
Kidney	0
Liver	0
Lung	0
Lymph node	0
Ovary	0
Pancreas	0
Parathyroid gland	0
Placenta	0
Prostate	0
Rectum	0
Salivary gland	0
Seminal vesicle	0
Skeletal muscle	0
Skin	0
Small intestine	0
Smooth muscle	0
Spleen	0
Stomach	0
Testis	139
Thyroid gland	0
Tonsil	0
Urinary bladder	0

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
TGCT	Testicular Germ Cell Tumors	150	-0.105	0.202	10.7	70.7	18.7	Neutral

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
TGCT	Testicular Germ Cell Tumors	-0.837	0	0	156	NA	NA	NS/NA

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	0	Not detected
Bone marrow	0	Not detected
Breast	0	Not detected
Bronchus	0	Not detected
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	0	Not detected
Colon	0	Not detected
Duodenum	0	Not detected
Endometrium	0	Not detected
Epididymis	0	Not detected
Esophagus	0	Not detected
Fallopian tube	0	Not detected
Gallbladder	0	Not detected
Heart muscle	0	Not detected
Hippocampus	0	Not detected
Kidney	0	Not detected
Liver	0	Not detected
Lung	0	Not detected
Lymph node	0	Not detected
Nasopharynx	0	Not detected
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	0	Not detected
Prostate	0	Not detected
Rectum	0	Not detected
Salivary gland	0	Not detected
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	0	Not detected
Small intestine	0	Not detected
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	0	Not detected
Stomach	0	Not detected
Testis	3	High
Thyroid gland	0	Not detected
Tonsil	0	Not detected
Urinary bladder	0	Not detected
Vagina	0	Not detected

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype [ TOP ]
There is no record.

> Overall survival

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
TGCT	Testicular Germ Cell Tumors	134	0	0.352	NS

> Stage

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
TGCT	Testicular Germ Cell Tumors	81	-0.253	0.0229	Lower

> Grade [ TOP ]
There is no data.

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for HDGFL1.

Summary
Symbol	HDGFL1
Name	HDGF like 1
Aliases	dJ309H15.1; PWWP1; PWWP domain containing 1; HDGF (hepatoma-derived growth factor) like; PWWP domain-contain ......
Location	6p22.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for HDGFL1.

> Interactions from Text Mining [ TOP ]
There is no record for HDGFL1.