Browse HDGFL2 in pancancer

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

Domain

PF11467 Lens epithelium-derived growth factor (LEDGF)
PF00855 PWWP domain

Function

Involved in cellular growth control, through the regulation of cyclin D1 expression.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H3K79me3, H4K20me3, H3K36me3	#	21720545

> Gene Ontology [ TOP ]
Biological Process	GO:0001558 regulation of cell growth GO:0016049 cell growth GO:0030307 positive regulation of cell growth GO:0045927 positive regulation of growth
Molecular Function	GO:0003682 chromatin binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC) [ TOP ]
There is no record for HDGFL2.

> Text Mining based Variations [ TOP ]
There is no record for HDGFL2.

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q7Z4V5	370	S	Phosphoserine	-	No	None detected
Q7Z4V5	454	S	Phosphoserine	-	Yes	p.S454A (cancer: UCEC)
Q7Z4V5	458	S	Phosphoserine	-	No	None detected
Q7Z4V5	625	S	Phosphoserine	-	No	None detected
Q7Z4V5	633	S	Phosphoserine	-	No	None detected
Q7Z4V5	634	S	Phosphoserine	-	No	None detected
Q7Z4V5	640	S	Phosphoserine	-	No	None detected
Q7Z4V5	664	S	Phosphoserine	-	No	None detected

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.993	6.426	0.447	0.00144	NS
BRCA	Breast invasive carcinoma	112	1100	5.077	5.729	0.747	2.11e-20	Over
CESC	Cervical and endocervical cancers	3	306	6.671	6.192	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.693	5.68	0.003	0.978	NS
ESCA	Esophageal carcinoma	11	185	4.88	5.282	0.399	0.0122	NS
GBM	Glioblastoma multiforme	5	166	6.423	5.975	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.369	5.698	0.341	0.000592	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.335	5.454	0.146	0.029	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.736	6.083	0.369	9.23e-05	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.033	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.573	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.905	5.58	0.682	5.03e-13	Over
LUAD	Lung adenocarcinoma	59	517	5.363	5.452	0.17	0.0296	NS
LUSC	Lung squamous cell carcinoma	51	501	5.282	5.698	0.581	3.82e-11	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.674	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.828	5.92	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.965	6.257	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.947	6.035	0.167	0.0227	NS
READ	Rectum adenocarcinoma	10	167	5.606	5.559	0.095	0.623	NS
SARC	Sarcoma	2	263	6.211	6.665	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.994	6.148	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.468	5.367	-0.129	0.218	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.545	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.676	6.076	0.387	2.8e-09	NS
THYM	Thymoma	2	120	6.518	7.094	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.454	6.315	-0.013	0.918	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

Tissue	Expression Level (TPM)
Adipose tissue	18.6
Adrenal gland	18.6
Appendix	22.7
Bone marrow	9.1
Breast	10.9
Cerebral cortex	42
Cervix, uterine	19.4
Colon	13.5
Duodenum	16.2
Endometrium	30.4
Epididymis	11.3
Esophagus	9.7
Fallopian tube	24.3
Gallbladder	15.4
Heart muscle	9.2
Kidney	12.1
Liver	6
Lung	17.1
Lymph node	20.3
Ovary	28.3
Pancreas	3
Parathyroid gland	19
Placenta	21.5
Prostate	22.1
Rectum	8.6
Salivary gland	7.8
Seminal vesicle	26.1
Skeletal muscle	23.5
Skin	20.2
Small intestine	16.5
Smooth muscle	18.5
Spleen	23.5
Stomach	13.6
Testis	62.3
Thyroid gland	14.2
Tonsil	11.2
Urinary bladder	12.6

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.443	7.35e-21	34.4	50.7	14.9	Loss
BRCA	Breast invasive carcinoma	1075	0.301	6.48e-24	27.8	57.6	14.6	Neutral
CESC	Cervical and endocervical cancers	292	0.529	1.81e-22	34.6	54.8	10.6	Loss
COAD	Colon adenocarcinoma	449	0.321	3.32e-12	13.1	71.7	15.1	Neutral
ESCA	Esophageal carcinoma	183	0.525	2.23e-14	47.5	39.3	13.1	Loss
GBM	Glioblastoma multiforme	147	0.391	9.95e-07	8.8	55.8	35.4	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.39	3.68e-20	29.2	61.3	9.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.037	0.392	3	88.2	8.8	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.173	0.00326	7.6	91	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.256	0.000884	2.4	94.6	3	Neutral
LGG	Brain Lower Grade Glioma	513	0.275	2.44e-10	4.3	73.5	22.2	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.414	1.68e-16	23.4	62.9	13.7	Neutral
LUAD	Lung adenocarcinoma	512	0.238	4.81e-08	53.7	42.6	3.7	Loss
LUSC	Lung squamous cell carcinoma	498	0.403	6.76e-21	42.2	40	17.9	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.572	1.82e-27	83.7	10.3	6	Loss
PAAD	Pancreatic adenocarcinoma	177	0.256	0.000598	18.6	75.1	6.2	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.203	0.00959	0.6	84.6	14.8	Neutral
PRAD	Prostate adenocarcinoma	491	0.181	5.25e-05	7.5	90.8	1.6	Neutral
READ	Rectum adenocarcinoma	164	0.489	2.99e-11	21.3	60.4	18.3	Neutral
SARC	Sarcoma	255	0.397	4.84e-11	14.5	47.8	37.6	Gain
SKCM	Skin Cutaneous Melanoma	367	0.382	3.17e-14	25.1	58.3	16.6	Neutral
STAD	Stomach adenocarcinoma	413	0.294	1.12e-09	37.3	56.2	6.5	Loss
TGCT	Testicular Germ Cell Tumors	150	-0.082	0.318	31.3	44.7	24	Neutral
THCA	Thyroid carcinoma	497	0.231	1.83e-07	1.6	97	1.4	Neutral
THYM	Thymoma	119	0.03	0.745	3.4	94.1	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.253	2.7e-09	28.1	69.3	2.6	Neutral

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR [ TOP ]
There is no record.

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	1	Low
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	3	High
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	3	High
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.00211	Significant	24476821
BRCA	Breast invasive carcinoma	521	0.467	NS	23000897
COAD	Colon adenocarcinoma	149	0.301	NS	22810696
GBM	Glioblastoma multiforme	157	7.11e-08	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	0.124	NS	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.691	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.13e-06	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.549	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.00373	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0035	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.708	NS	26544944
READ	Rectum adenocarcinoma	67	0.775	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.663	NS	26091043
STAD	Stomach adenocarcinoma	277	0.49	NS	25079317
THCA	Thyroid carcinoma	391	5.06e-11	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.000233	Significant	23636398

> Overall survival

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.985	0.94	NS
BRCA	Breast invasive carcinoma	1079	0.986	0.95	NS
CESC	Cervical and endocervical cancers	291	0.692	0.328	NS
COAD	Colon adenocarcinoma	439	0.985	0.96	NS
ESCA	Esophageal carcinoma	184	0.821	0.558	NS
GBM	Glioblastoma multiforme	158	0.831	0.469	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.754	0.163	NS
KIRC	Kidney renal clear cell carcinoma	531	2.199	0.000273	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.893	0.803	NS
LAML	Acute Myeloid Leukemia	149	1.593	0.092	NS
LGG	Brain Lower Grade Glioma	511	0.847	0.485	NS
LIHC	Liver hepatocellular carcinoma	365	1.192	0.49	NS
LUAD	Lung adenocarcinoma	502	1.22	0.358	NS
LUSC	Lung squamous cell carcinoma	494	0.822	0.309	NS
OV	Ovarian serous cystadenocarcinoma	303	1.055	0.793	NS
PAAD	Pancreatic adenocarcinoma	177	0.44	0.00479	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	1.973	0.572	NS
PRAD	Prostate adenocarcinoma	497	4.213	0.163	NS
READ	Rectum adenocarcinoma	159	1.939	0.22	NS
SARC	Sarcoma	259	1.001	0.995	NS
SKCM	Skin Cutaneous Melanoma	459	1.233	0.263	NS
STAD	Stomach adenocarcinoma	388	0.701	0.0941	NS
TGCT	Testicular Germ Cell Tumors	134	0.822	0.889	NS
THCA	Thyroid carcinoma	500	0.71	0.589	NS
THYM	Thymoma	119	1.061	0.967	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.679	0.188	NS

> Stage

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.058	0.243	NS
BRCA	Breast invasive carcinoma	1071	0.034	0.269	NS
CESC	Cervical and endocervical cancers	167	0.012	0.881	NS
COAD	Colon adenocarcinoma	445	0.015	0.747	NS
ESCA	Esophageal carcinoma	162	-0.036	0.653	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.083	0.079	NS
KIRC	Kidney renal clear cell carcinoma	531	0.145	0.000832	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.082	0.187	NS
LIHC	Liver hepatocellular carcinoma	347	-0.018	0.742	NS
LUAD	Lung adenocarcinoma	507	-0.001	0.978	NS
LUSC	Lung squamous cell carcinoma	497	0.047	0.294	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.05	0.386	NS
PAAD	Pancreatic adenocarcinoma	176	-0.188	0.0126	Lower
READ	Rectum adenocarcinoma	156	0.1	0.216	NS
SKCM	Skin Cutaneous Melanoma	410	-0.074	0.137	NS
STAD	Stomach adenocarcinoma	392	-0.133	0.0083	Lower
TGCT	Testicular Germ Cell Tumors	81	0.33	0.00264	Higher
THCA	Thyroid carcinoma	499	0.093	0.0383	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.024	0.589	NS

> Grade

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.088	0.149	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.112	0.0125	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.105	0.0164	Higher
LGG	Brain Lower Grade Glioma	514	0.012	0.783	NS
LIHC	Liver hepatocellular carcinoma	366	0.058	0.268	NS
OV	Ovarian serous cystadenocarcinoma	296	0.082	0.162	NS
PAAD	Pancreatic adenocarcinoma	176	-0.045	0.55	NS
STAD	Stomach adenocarcinoma	406	0.05	0.315	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.103	0.0171	Higher

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for HDGFL2.

Summary
Symbol	HDGFL2
Name	HDGF like 2
Aliases
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for HDGFL2.

> Interactions from Text Mining [ TOP ]
There is no record for HDGFL2.