CR2Cancer

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00271 Helicase conserved C-terminal domain
PF00176 SNF2 family N-terminal domain

Function

Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling	#	#	#	14612388

> Gene Ontology [ TOP ]
Biological Process	GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0006346 methylation-dependent chromatin silencing GO:0007067 mitotic nuclear division GO:0010216 maintenance of DNA methylation GO:0016458 gene silencing GO:0031055 chromatin remodeling at centromere GO:0031497 chromatin assembly GO:0031507 heterochromatin assembly GO:0031508 pericentric heterochromatin assembly GO:0032943 mononuclear cell proliferation GO:0034508 centromere complex assembly GO:0040029 regulation of gene expression, epigenetic GO:0045814 negative regulation of gene expression, epigenetic GO:0046651 lymphocyte proliferation GO:0065004 protein-DNA complex assembly GO:0070661 leukocyte proliferation GO:0070828 heterochromatin organization GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization
Molecular Function	GO:0004386 helicase activity
Cellular Component	GO:0000775 chromosome, centromeric region GO:0000785 chromatin GO:0000792 heterochromatin GO:0005721 pericentric heterochromatin GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3978955	c.1033-10C>T	p.?	Unknown	Lung
COSM4983546	c.2392G>A	p.E798K	Substitution - Missense	Oesophagus
COSM5747157	c.1964_1965insA	p.N657fs*26	Insertion - Frameshift	Pancreas
COSM210978	c.1524delA	p.K509fs*8	Deletion - Frameshift	Haematopoietic_and_lymphoid_tissue
COSM325485	c.280C>A	p.Q94K	Substitution - Missense	Lung
COSM4689966	c.1390C>T	p.R464*	Substitution - Nonsense	Large_intestine
COSM240097	c.1796G>C	p.G599A	Substitution - Missense	Prostate
COSM921724	c.2454G>T	p.E818D	Substitution - Missense	Endometrium
COSM4689972	c.2155G>A	p.V719I	Substitution - Missense	Large_intestine
COSM275448	c.292G>T	p.E98*	Substitution - Nonsense	Large_intestine
COSM5515367	c.1492G>T	p.E498*	Substitution - Nonsense	Biliary_tract
COSM921723	c.2408G>A	p.R803Q	Substitution - Missense	Cervix
COSM921714	c.536C>T	p.S179L	Substitution - Missense	Endometrium
COSM3998140	c.231A>C	p.I77I	Substitution - coding silent	Upper_aerodigestive_tract
COSM5494640	c.1628+1G>A	p.?	Unknown	Biliary_tract
COSM3786950	c.2023C>T	p.R675*	Substitution - Nonsense	Pancreas
COSM466115	c.819T>C	p.P273P	Substitution - coding silent	Kidney
COSM5718949	c.344C>T	p.S115L	Substitution - Missense	Skin
COSM275448	c.292G>T	p.E98*	Substitution - Nonsense	Endometrium
COSM466118	c.1852-2A>T	p.?	Unknown	Kidney
COSM3978957	c.1238C>G	p.S413C	Substitution - Missense	Lung
COSM4016862	c.1952A>G	p.Y651C	Substitution - Missense	Stomach
COSM4395485	c.2163C>T	p.R721R	Substitution - coding silent	Skin
COSM240096	c.190C>T	p.R64W	Substitution - Missense	Skin
COSM3726960	c.1175A>G	p.E392G	Substitution - Missense	Skin
COSM3998140	c.231A>C	p.I77I	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1741960	c.1264G>C	p.E422Q	Substitution - Missense	Urinary_tract
COSM4016860	c.1761A>G	p.E587E	Substitution - coding silent	Stomach
COSM1578530	c.1971+1_1971+2insT	p.?	Unknown	Meninges
COSM240096	c.190C>T	p.R64W	Substitution - Missense	Oesophagus
COSM3808057	c.671G>A	p.R224Q	Substitution - Missense	Breast
COSM51927	c.1847A>G	p.H616R	Substitution - Missense	Kidney
COSM1970745	c.2250T>C	p.N750N	Substitution - coding silent	Skin
COSM1638697	c.2249-10delT	p.?	Unknown	Stomach
COSM921716	c.1276G>T	p.D426Y	Substitution - Missense	Endometrium
COSM1160966	c.236C>T	p.S79F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4689974	c.2266C>T	p.Q756*	Substitution - Nonsense	Large_intestine
COSM921719	c.2146C>T	p.P716S	Substitution - Missense	Endometrium
COSM5012209	c.2012T>G	p.L671*	Substitution - Nonsense	Kidney
COSM354965	c.792G>T	p.L264F	Substitution - Missense	Lung
COSM1349988	c.1549A>C	p.N517H	Substitution - Missense	Large_intestine
COSM4806058	c.1999G>T	p.V667L	Substitution - Missense	Liver
COSM3786950	c.2023C>T	p.R675*	Substitution - Nonsense	Pancreas
COSM1662121	c.1803C>G	p.F601L	Substitution - Missense	Kidney
COSM1970729	c.1116A>G	p.R372R	Substitution - coding silent	Kidney
COSM5748809	c.1543T>C	p.S515P	Substitution - Missense	Pancreas
COSM1638697	c.2249-10delT	p.?	Unknown	Stomach
COSM3998140	c.231A>C	p.I77I	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM921713	c.340A>C	p.N114H	Substitution - Missense	Endometrium
COSM5901652	c.436G>A	p.E146K	Substitution - Missense	Skin
COSM3415380	c.252G>A	p.T84T	Substitution - coding silent	Large_intestine
COSM4422671	c.2370G>A	p.K790K	Substitution - coding silent	Kidney
COSM394061	c.190C>G	p.R64G	Substitution - Missense	Lung
COSM3770712	c.617A>G	p.N206S	Substitution - Missense	Pancreas
COSM1187999	c.1717C>T	p.H573Y	Substitution - Missense	Lung
COSM5761004	c.2353A>G	p.K785E	Substitution - Missense	Pancreas
COSM4759055	c.284A>C	p.K95T	Substitution - Missense	Stomach
COSM3441890	c.1845T>G	p.G615G	Substitution - coding silent	Skin
COSM4647221	c.1521A>G	p.R507R	Substitution - coding silent	Large_intestine
COSM4016864	c.2120G>A	p.R707K	Substitution - Missense	Stomach
COSM3415382	c.1532G>A	p.R511Q	Substitution - Missense	Large_intestine
COSM1349982	c.158G>A	p.R53H	Substitution - Missense	Large_intestine
COSM1702785	c.1510C>T	p.P504S	Substitution - Missense	Skin
COSM281669	c.2162G>A	p.R721H	Substitution - Missense	Large_intestine
COSM1970710	c.180G>A	p.S60S	Substitution - coding silent	Large_intestine
COSM3441888	c.1702C>T	p.R568C	Substitution - Missense	Skin
COSM4759060	c.1234G>C	p.E412Q	Substitution - Missense	Stomach
COSM4759062	c.2234T>C	p.L745S	Substitution - Missense	Stomach
COSM3441882	c.502C>T	p.L168F	Substitution - Missense	Skin
COSM4689968	c.1450G>C	p.V484L	Substitution - Missense	Large_intestine
COSM4016853	c.193T>C	p.Y65H	Substitution - Missense	Stomach
COSM5758755	c.2263G>C	p.G755R	Substitution - Missense	Bone
COSM921714	c.536C>T	p.S179L	Substitution - Missense	Skin
COSM921720	c.2185G>A	p.D729N	Substitution - Missense	Endometrium
COSM1349984	c.685G>A	p.E229K	Substitution - Missense	Large_intestine
COSM921723	c.2408G>A	p.R803Q	Substitution - Missense	Endometrium
COSM921715	c.1194C>G	p.N398K	Substitution - Missense	Endometrium
COSM1970725	c.955C>T	p.R319W	Substitution - Missense	Stomach
COSM4593599	c.1706A>C	p.K569T	Substitution - Missense	Upper_aerodigestive_tract
COSM3441884	c.601C>T	p.P201S	Substitution - Missense	Skin
COSM5999069	c.1458T>C	p.R486R	Substitution - coding silent	Prostate
COSM348312	c.1138C>A	p.L380I	Substitution - Missense	Lung
COSM4469078	c.157C>T	p.R53C	Substitution - Missense	Skin
COSM5718949	c.344C>T	p.S115L	Substitution - Missense	Skin
COSM4806058	c.1999G>T	p.V667L	Substitution - Missense	Liver
COSM3786950	c.2023C>T	p.R675*	Substitution - Nonsense	Large_intestine
COSM4016858	c.1341C>T	p.F447F	Substitution - coding silent	Stomach
COSM4569886	c.2127T>C	p.H709H	Substitution - coding silent	Skin
COSM5989095	c.560T>C	p.L187S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM921718	c.1971C>T	p.N657N	Substitution - coding silent	Endometrium
COSM4982011	c.2207C>A	p.A736E	Substitution - Missense	Oesophagus
COSM3935233	c.988A>G	p.I330V	Substitution - Missense	Oesophagus
COSM1970711	c.213G>A	p.L71L	Substitution - coding silent	Large_intestine
COSM5570078	c.1536T>C	p.T512T	Substitution - coding silent	Prostate
COSM5718949	c.344C>T	p.S115L	Substitution - Missense	Skin
COSM921721	c.2289G>T	p.K763N	Substitution - Missense	Endometrium
COSM1209511	c.2482A>C	p.N828H	Substitution - Missense	Large_intestine
COSM3808059	c.2207C>T	p.A736V	Substitution - Missense	Breast
COSM921717	c.1928G>A	p.S643N	Substitution - Missense	Endometrium
COSM5371367	c.1574C>T	p.P525L	Substitution - Missense	Skin
COSM1638697	c.2249-10delT	p.?	Unknown	Biliary_tract
COSM240096	c.190C>T	p.R64W	Substitution - Missense	Prostate
COSM466116	c.1580A>C	p.E527A	Substitution - Missense	Kidney
COSM5765008	c.537G>A	p.S179S	Substitution - coding silent	Large_intestine
COSM1349985	c.1025C>T	p.A342V	Substitution - Missense	Large_intestine
COSM4016851	c.32G>A	p.G11D	Substitution - Missense	Stomach
COSM1349987	c.1215T>C	p.F405F	Substitution - coding silent	Large_intestine
COSM79965	c.1186T>C	p.L396L	Substitution - coding silent	Ovary
COSM1349989	c.1833delA	p.R614fs*11	Deletion - Frameshift	Breast
COSM5587977	c.2472G>T	p.K824N	Substitution - Missense	Skin
COSM1970728	c.1095T>G	p.R365R	Substitution - coding silent	Upper_aerodigestive_tract
COSM4689964	c.1224delG	p.S410fs*35	Deletion - Frameshift	Large_intestine
COSM921722	c.2291A>C	p.N764T	Substitution - Missense	Endometrium
COSM3808055	c.151A>C	p.K51Q	Substitution - Missense	Breast
COSM4573921	c.1531C>A	p.R511R	Substitution - coding silent	Bone
COSM5718949	c.344C>T	p.S115L	Substitution - Missense	Skin
COSM3358923	c.2154T>G	p.V718V	Substitution - coding silent	Kidney
COSM4689970	c.1528C>T	p.R510*	Substitution - Nonsense	Large_intestine
COSM287712	c.2061T>C	p.D687D	Substitution - coding silent	Large_intestine
COSM4016855	c.682G>A	p.V228I	Substitution - Missense	Stomach
COSM3368162	c.2466A>G	p.I822M	Substitution - Missense	Thyroid
COSM5935593	c.889-3C>T	p.?	Unknown	Skin
COSM123565	c.1136T>G	p.L379R	Substitution - Missense	Upper_aerodigestive_tract
COSM5888083	c.1770C>T	p.I590I	Substitution - coding silent	Upper_aerodigestive_tract
COSM466117	c.1700T>C	p.L567P	Substitution - Missense	Kidney
COSM3441886	c.1444G>A	p.A482T	Substitution - Missense	Skin
COSM1349990	c.2100G>A	p.S700S	Substitution - coding silent	Large_intestine
COSM1180742	c.1832_1833insA	p.R614fs*33	Insertion - Frameshift	Large_intestine
COSM3791046	c.309A>T	p.K103N	Substitution - Missense	Urinary_tract
COSM1209512	c.347T>C	p.I116T	Substitution - Missense	Large_intestine
COSM3967237	c.1941G>A	p.G647G	Substitution - coding silent	Central_nervous_system

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
10910076	mutation	Leukemia	Examination of acute myelogenous leukemia and acute lymphoblastic leukemia samples revealed a high frequency of a PASG transcript containing an in-frame 75-nucleotide deletion, which codes for a conserved motif known to be critical for the transactivation activity of a related yeast SWI/SNF polypeptide.

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9NRZ9	503	S	Phosphoserine	-	No	None detected
Q9NRZ9	515	S	Phosphoserine	-	No	None detected

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	1.913	3.514	2.277	5.39e-20	Over
BRCA	Breast invasive carcinoma	112	1100	1.025	3.032	2.174	1.65e-78	Over
CESC	Cervical and endocervical cancers	3	306	0.287	4.406	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	2.052	3.545	1.647	3.87e-29	Over
ESCA	Esophageal carcinoma	11	185	2.118	4.37	2.332	1.79e-15	Over
GBM	Glioblastoma multiforme	5	166	-1.99	1.865	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	2.43	3.328	1.201	8.51e-16	Over
KIRC	Kidney renal clear cell carcinoma	72	534	1.78	1.461	-0.346	0.00135	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	1.354	1.276	0.005	0.984	NS
LAML	Acute Myeloid Leukemia	0	173	NA	5.103	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	0.468	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	-1.618	0.85	2.617	8.71e-27	Over
LUAD	Lung adenocarcinoma	59	517	-0.301	2.452	2.713	1.84e-52	Over
LUSC	Lung squamous cell carcinoma	51	501	-0.044	3.844	3.858	5.89e-118	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	2.892	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	1.039	2.075	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	-0.029	1.128	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	0.483	0.658	0.261	0.086	NS
READ	Rectum adenocarcinoma	10	167	2.086	3.48	1.327	1.84e-05	Over
SARC	Sarcoma	2	263	0.55	2.542	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.249	2.69	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	2.013	3.945	2.506	4.7e-35	Over
TGCT	Testicular Germ Cell Tumors	0	156	NA	6.056	NA	NA	NA
THCA	Thyroid carcinoma	59	509	0.161	1.247	0.894	2.89e-10	Over
THYM	Thymoma	2	120	3.377	3.785	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	0.987	3.31	2.062	7.57e-30	Over

> Cancer Cell Line Encyclopedia (CCLE)

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Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	9.2
Autonomic ganglia	CHP212	9.3
Autonomic ganglia	IMR32	9.6
Autonomic ganglia	KELLY	10.3
Autonomic ganglia	KPNRTBM1	9.4
Autonomic ganglia	KPNSI9S	8.2
Autonomic ganglia	KPNYN	9.5
Autonomic ganglia	MHHNB11	9.8
Autonomic ganglia	NB1	8.8
Autonomic ganglia	NH6	9.2
Autonomic ganglia	SHSY5Y	8
Autonomic ganglia	SIMA	8.6
Autonomic ganglia	SKNAS	8.3
Autonomic ganglia	SKNBE2	9.4
Autonomic ganglia	SKNDZ	10.2
Autonomic ganglia	SKNFI	8.8
Autonomic ganglia	SKNSH	8.1
Biliary tract	HUCCT1	9.7
Biliary tract	HUH28	7.8
Biliary tract	SNU1079	8.2
Biliary tract	SNU1196	8.8
Biliary tract	SNU245	9.5
Biliary tract	SNU308	9.2
Biliary tract	SNU478	9.1
Bone	143B	10.6
Bone	A673	9.4
Bone	CADOES1	8.4
Bone	CAL78	8.5
Bone	G292CLONEA141B1	9.4
Bone	HOS	9.9
Bone	HS706T	8.1
Bone	HS737T	7.1
Bone	HS819T	6.1
Bone	HS821T	7.4
Bone	HS822T	5.2
Bone	HS863T	8.5
Bone	HS870T	9
Bone	HS888T	8
Bone	MG63	8.8
Bone	MHHES1	8.2
Bone	OUMS27	9.3
Bone	RDES	9
Bone	SJSA1	9.2
Bone	SKES1	9.3
Bone	SKNMC	9.1
Bone	SW1353	8.1
Bone	T173	8.3
Bone	TC71	9.7
Bone	U2OS	8.8
Breast	AU565	8.2
Breast	BT20	8.3
Breast	BT474	8.8
Breast	BT483	8
Breast	BT549	8.5
Breast	CAL120	7.1
Breast	CAL148	8.2
Breast	CAL51	10.2
Breast	CAL851	9.2
Breast	CAMA1	9.4
Breast	DU4475	9.2
Breast	EFM192A	9.2
Breast	EFM19	9.5
Breast	EVSAT	8.6
Breast	HCC1143	9.2
Breast	HCC1187	9.1
Breast	HCC1395	8.3
Breast	HCC1419	8.2
Breast	HCC1428	9.1
Breast	HCC1500	8.7
Breast	HCC1569	7.8
Breast	HCC1599	9.3
Breast	HCC1806	9.2
Breast	HCC1937	9
Breast	HCC1954	8.7
Breast	HCC202	8.9
Breast	HCC2157	8.5
Breast	HCC2218	8
Breast	HCC38	9.3
Breast	HCC70	8.8
Breast	HDQP1	8
Breast	HMC18	9.1
Breast	HS274T	7.6
Breast	HS281T	8.1
Breast	HS343T	8.5
Breast	HS578T	6
Breast	HS606T	7
Breast	HS739T	7.3
Breast	HS742T	4.9
Breast	JIMT1	7.5
Breast	KPL1	8.9
Breast	MCF7	9.5
Breast	MDAMB134VI	8.7
Breast	MDAMB157	8.6
Breast	MDAMB175VII	8.9
Breast	MDAMB231	8.8
Breast	MDAMB361	8.9
Breast	MDAMB415	8.4
Breast	MDAMB436	8.9
Breast	MDAMB453	9.6
Breast	MDAMB468	8.5
Breast	SKBR3	8.3
Breast	T47D	10.2
Breast	UACC812	9.1
Breast	UACC893	9
Breast	YMB1	7.9
Breast	ZR751	8.7
Breast	ZR7530	8.9
Central nervous system	1321N1	9.4
Central nervous system	42MGBA	9.3
Central nervous system	8MGBA	8.7
Central nervous system	A172	8.2
Central nervous system	AM38	9.5
Central nervous system	BECKER	8.8
Central nervous system	CAS1	7.4
Central nervous system	CCFSTTG1	9.7
Central nervous system	D283MED	9.7
Central nervous system	D341MED	6.4
Central nervous system	DAOY	8.8
Central nervous system	DBTRG05MG	7.7
Central nervous system	DKMG	6.7
Central nervous system	GAMG	9
Central nervous system	GB1	9.6
Central nervous system	GI1	9.5
Central nervous system	GMS10	9
Central nervous system	GOS3	7.4
Central nervous system	H4	8.9
Central nervous system	HS683	8.5
Central nervous system	KALS1	8
Central nervous system	KG1C	7.5
Central nervous system	KNS42	9.1
Central nervous system	KNS60	8.9
Central nervous system	KNS81	7.5
Central nervous system	KS1	9.6
Central nervous system	LN18	9.9
Central nervous system	LN229	9
Central nervous system	M059K	8.4
Central nervous system	MOGGCCM	7.8
Central nervous system	MOGGUVW	8
Central nervous system	NMCG1	8.6
Central nervous system	ONS76	8.9
Central nervous system	SF126	9.2
Central nervous system	SF295	8.4
Central nervous system	SNB19	9.6
Central nervous system	SNU1105	7.5
Central nervous system	SNU201	6.3
Central nervous system	SNU466	6.6
Central nervous system	SNU489	4.8
Central nervous system	SNU626	7.3
Central nervous system	SNU738	7.9
Central nervous system	SW1088	8.7
Central nervous system	SW1783	8.6
Central nervous system	T98G	7.8
Central nervous system	TM31	9
Central nervous system	U118MG	8.4
Central nervous system	U138MG	7.5
Central nervous system	U251MG	8.1
Central nervous system	U87MG	8.3
Central nervous system	YH13	7.6
Central nervous system	YKG1	8.4
Endometrium	AN3CA	10.7
Endometrium	COLO684	8.6
Endometrium	EFE184	7.8
Endometrium	EN	9.3
Endometrium	ESS1	9.5
Endometrium	HEC108	9.5
Endometrium	HEC151	9.7
Endometrium	HEC1A	10.2
Endometrium	HEC1B	9
Endometrium	HEC251	9.2
Endometrium	HEC265	9.1
Endometrium	HEC50B	9.8
Endometrium	HEC59	10.1
Endometrium	HEC6	10
Endometrium	ISHIKAWAHERAKLIO02ER	9.4
Endometrium	JHUEM1	8.7
Endometrium	JHUEM2	9.9
Endometrium	JHUEM3	8.6
Endometrium	KLE	8.6
Endometrium	MFE280	9.2
Endometrium	MFE296	9.5
Endometrium	MFE319	8.4
Endometrium	RL952	9.4
Endometrium	SNGM	7.3
Endometrium	SNU1077	8.5
Endometrium	SNU685	7.6
Endometrium	TEN	9.4
Haematopoietic and lymphoid	697	10
Haematopoietic and lymphoid	A3KAW	9.3
Haematopoietic and lymphoid	A4FUK	8.3
Haematopoietic and lymphoid	ALLSIL	10.1
Haematopoietic and lymphoid	AML193	9.4
Haematopoietic and lymphoid	AMO1	9.6
Haematopoietic and lymphoid	BCP1	9.9
Haematopoietic and lymphoid	BDCM	10.5
Haematopoietic and lymphoid	BL41	10.4
Haematopoietic and lymphoid	BL70	10.1
Haematopoietic and lymphoid	BV173	9.3
Haematopoietic and lymphoid	CA46	8.9
Haematopoietic and lymphoid	CI1	10.9
Haematopoietic and lymphoid	CMK115	10.1
Haematopoietic and lymphoid	CMK86	9.2
Haematopoietic and lymphoid	CMK	9.4
Haematopoietic and lymphoid	CMLT1	8.7
Haematopoietic and lymphoid	COLO775	7.6
Haematopoietic and lymphoid	DAUDI	10.3
Haematopoietic and lymphoid	DB	9.4
Haematopoietic and lymphoid	DEL	7.7
Haematopoietic and lymphoid	DND41	9.1
Haematopoietic and lymphoid	DOHH2	10.1
Haematopoietic and lymphoid	EB1	9
Haematopoietic and lymphoid	EB2	8.2
Haematopoietic and lymphoid	EHEB	8.9
Haematopoietic and lymphoid	EJM	9.6
Haematopoietic and lymphoid	EM2	8.9
Haematopoietic and lymphoid	EOL1	9
Haematopoietic and lymphoid	F36P	7.6
Haematopoietic and lymphoid	GA10	10.4
Haematopoietic and lymphoid	GDM1	9.1
Haematopoietic and lymphoid	GRANTA519	9.4
Haematopoietic and lymphoid	HDLM2	9.9
Haematopoietic and lymphoid	HDMYZ	8
Haematopoietic and lymphoid	HEL9217	9.2
Haematopoietic and lymphoid	HEL	8.9
Haematopoietic and lymphoid	HH	9.8
Haematopoietic and lymphoid	HL60	8.9
Haematopoietic and lymphoid	HPBALL	9.3
Haematopoietic and lymphoid	HS604T	6.1
Haematopoietic and lymphoid	HS611T	10.7
Haematopoietic and lymphoid	HS616T	6.8
Haematopoietic and lymphoid	HS751T	8.1
Haematopoietic and lymphoid	HT	10.1
Haematopoietic and lymphoid	HTK	9.2
Haematopoietic and lymphoid	HUNS1	10.4
Haematopoietic and lymphoid	HUT102	9.9
Haematopoietic and lymphoid	HUT78	9.8
Haematopoietic and lymphoid	JEKO1	9.4
Haematopoietic and lymphoid	JK1	8.3
Haematopoietic and lymphoid	JM1	10.2
Haematopoietic and lymphoid	JURKAT	8.5
Haematopoietic and lymphoid	JURLMK1	8.7
Haematopoietic and lymphoid	JVM2	8.3
Haematopoietic and lymphoid	JVM3	8.3
Haematopoietic and lymphoid	K562	7.8
Haematopoietic and lymphoid	KARPAS299	7.6
Haematopoietic and lymphoid	KARPAS422	8.7
Haematopoietic and lymphoid	KARPAS620	9.1
Haematopoietic and lymphoid	KASUMI1	9.3
Haematopoietic and lymphoid	KASUMI2	10.3
Haematopoietic and lymphoid	KASUMI6	9.5
Haematopoietic and lymphoid	KCL22	9.1
Haematopoietic and lymphoid	KE37	9.6
Haematopoietic and lymphoid	KE97	10.2
Haematopoietic and lymphoid	KG1	10.4
Haematopoietic and lymphoid	KHM1B	8.5
Haematopoietic and lymphoid	KIJK	9.4
Haematopoietic and lymphoid	KMH2	9.3
Haematopoietic and lymphoid	KMM1	10.8
Haematopoietic and lymphoid	KMS11	9.2
Haematopoietic and lymphoid	KMS12BM	10
Haematopoietic and lymphoid	KMS18	9.7
Haematopoietic and lymphoid	KMS20	9.3
Haematopoietic and lymphoid	KMS21BM	8.6
Haematopoietic and lymphoid	KMS26	9.2
Haematopoietic and lymphoid	KMS27	9.6
Haematopoietic and lymphoid	KMS28BM	10.1
Haematopoietic and lymphoid	KMS34	9.4
Haematopoietic and lymphoid	KO52	8.9
Haematopoietic and lymphoid	KOPN8	9.4
Haematopoietic and lymphoid	KU812	8.5
Haematopoietic and lymphoid	KYO1	8.5
Haematopoietic and lymphoid	L1236	9.2
Haematopoietic and lymphoid	L363	8.2
Haematopoietic and lymphoid	L428	10.4
Haematopoietic and lymphoid	L540	9
Haematopoietic and lymphoid	LAMA84	8.8
Haematopoietic and lymphoid	LOUCY	10.2
Haematopoietic and lymphoid	LP1	7
Haematopoietic and lymphoid	M07E	9.3
Haematopoietic and lymphoid	MC116	9.4
Haematopoietic and lymphoid	ME1	7.5
Haematopoietic and lymphoid	MEC1	10.9
Haematopoietic and lymphoid	MEC2	9.5
Haematopoietic and lymphoid	MEG01	8
Haematopoietic and lymphoid	MHHCALL2	9.7
Haematopoietic and lymphoid	MHHCALL3	9.7
Haematopoietic and lymphoid	MHHCALL4	9.3
Haematopoietic and lymphoid	MINO	10.1
Haematopoietic and lymphoid	MJ	10
Haematopoietic and lymphoid	MM1S	9.3
Haematopoietic and lymphoid	MOLM13	9.3
Haematopoietic and lymphoid	MOLM16	8.8
Haematopoietic and lymphoid	MOLM6	8.7
Haematopoietic and lymphoid	MOLP2	6.6
Haematopoietic and lymphoid	MOLP8	7.4
Haematopoietic and lymphoid	MOLT13	9.8
Haematopoietic and lymphoid	MOLT16	8.6
Haematopoietic and lymphoid	MOLT4	10.5
Haematopoietic and lymphoid	MONOMAC1	8.7
Haematopoietic and lymphoid	MONOMAC6	10.4
Haematopoietic and lymphoid	MOTN1	9.7
Haematopoietic and lymphoid	MUTZ5	9.4
Haematopoietic and lymphoid	MV411	9.5
Haematopoietic and lymphoid	NALM19	9.4
Haematopoietic and lymphoid	NALM1	9.1
Haematopoietic and lymphoid	NALM6	10.5
Haematopoietic and lymphoid	NAMALWA	9.5
Haematopoietic and lymphoid	NB4	8.9
Haematopoietic and lymphoid	NCIH929	8.9
Haematopoietic and lymphoid	NCO2	9.6
Haematopoietic and lymphoid	NOMO1	9.1
Haematopoietic and lymphoid	NUDHL1	7.4
Haematopoietic and lymphoid	NUDUL1	9.8
Haematopoietic and lymphoid	OCIAML2	9.7
Haematopoietic and lymphoid	OCIAML3	7.9
Haematopoietic and lymphoid	OCIAML5	8.6
Haematopoietic and lymphoid	OCILY10	9.5
Haematopoietic and lymphoid	OCILY19	9.6
Haematopoietic and lymphoid	OCILY3	10.9
Haematopoietic and lymphoid	OCIM1	8.3
Haematopoietic and lymphoid	OPM2	8
Haematopoietic and lymphoid	P12ICHIKAWA	9
Haematopoietic and lymphoid	P31FUJ	8.7
Haematopoietic and lymphoid	P3HR1	10.4
Haematopoietic and lymphoid	PCM6	8.5
Haematopoietic and lymphoid	PEER	10.4
Haematopoietic and lymphoid	PF382	9.9
Haematopoietic and lymphoid	PFEIFFER	9.9
Haematopoietic and lymphoid	PL21	8.5
Haematopoietic and lymphoid	RAJI	10.2
Haematopoietic and lymphoid	RCHACV	10
Haematopoietic and lymphoid	REC1	9.6
Haematopoietic and lymphoid	REH	10.3
Haematopoietic and lymphoid	RI1	9.4
Haematopoietic and lymphoid	RL	10.3
Haematopoietic and lymphoid	RPMI8226	8.6
Haematopoietic and lymphoid	RPMI8402	9.1
Haematopoietic and lymphoid	RS411	10
Haematopoietic and lymphoid	SEM	9.8
Haematopoietic and lymphoid	SET2	8.7
Haematopoietic and lymphoid	SIGM5	8.2
Haematopoietic and lymphoid	SKM1	9.6
Haematopoietic and lymphoid	SKMM2	8.9
Haematopoietic and lymphoid	SR786	8
Haematopoietic and lymphoid	ST486	10.4
Haematopoietic and lymphoid	SUDHL10	8.2
Haematopoietic and lymphoid	SUDHL1	9.4
Haematopoietic and lymphoid	SUDHL4	8.8
Haematopoietic and lymphoid	SUDHL5	10.1
Haematopoietic and lymphoid	SUDHL6	9.9
Haematopoietic and lymphoid	SUDHL8	9.4
Haematopoietic and lymphoid	SUPB15	10.2
Haematopoietic and lymphoid	SUPHD1	8.4
Haematopoietic and lymphoid	SUPM2	7.8
Haematopoietic and lymphoid	SUPT11	8.8
Haematopoietic and lymphoid	SUPT1	10.1
Haematopoietic and lymphoid	TALL1	10.7
Haematopoietic and lymphoid	TF1	9
Haematopoietic and lymphoid	THP1	8.2
Haematopoietic and lymphoid	TO175T	8.3
Haematopoietic and lymphoid	TOLEDO	10.3
Haematopoietic and lymphoid	U266B1	9.4
Haematopoietic and lymphoid	U937	8.1
Haematopoietic and lymphoid	UT7	7.9
Haematopoietic and lymphoid	WSUDLCL2	9.4
Kidney	769P	8.6
Kidney	786O	8.1
Kidney	A498	7.3
Kidney	A704	8
Kidney	ACHN	9.5
Kidney	BFTC909	7.7
Kidney	CAKI1	8.1
Kidney	CAKI2	8.6
Kidney	CAL54	8.4
Kidney	KMRC1	8.7
Kidney	KMRC20	8.2
Kidney	KMRC2	8.7
Kidney	KMRC3	6.9
Kidney	OSRC2	8.2
Kidney	RCC10RGB	7.6
Kidney	SNU1272	8.3
Kidney	SNU349	6.4
Kidney	TUHR10TKB	8.1
Kidney	TUHR14TKB	6.2
Kidney	TUHR4TKB	7.1
Kidney	VMRCRCW	5.4
Kidney	VMRCRCZ	8.3
Large intestine	C2BBE1	10.3
Large intestine	CCK81	9.5
Large intestine	CL11	9.1
Large intestine	CL14	8
Large intestine	CL34	9.4
Large intestine	CL40	7.7
Large intestine	COLO205	9.9
Large intestine	COLO320	9.5
Large intestine	COLO678	9.4
Large intestine	CW2	9.3
Large intestine	DLD1	10.4
Large intestine	GP2D	10.1
Large intestine	HCC56	8.7
Large intestine	HCT116	9.9
Large intestine	HCT15	10.5
Large intestine	HS675T	7.3
Large intestine	HS698T	8.3
Large intestine	HT115	9
Large intestine	HT29	9.2
Large intestine	HT55	8.9
Large intestine	KM12	9.5
Large intestine	LOVO	9.8
Large intestine	LS1034	9.8
Large intestine	LS123	8.8
Large intestine	LS180	9.2
Large intestine	LS411N	10.6
Large intestine	LS513	8.5
Large intestine	MDST8	8.1
Large intestine	NCIH508	7.3
Large intestine	NCIH716	8.5
Large intestine	NCIH747	9.8
Large intestine	OUMS23	8.2
Large intestine	RCM1	8
Large intestine	RKO	9.9
Large intestine	SKCO1	9.6
Large intestine	SNU1040	8
Large intestine	SNU1197	8.3
Large intestine	SNU175	7.6
Large intestine	SNU283	9.2
Large intestine	SNU407	8.9
Large intestine	SNU503	9.3
Large intestine	SNU61	9.8
Large intestine	SNU81	7.7
Large intestine	SNUC1	8.5
Large intestine	SNUC2A	8.9
Large intestine	SNUC4	8.9
Large intestine	SNUC5	9.3
Large intestine	SW1116	9.4
Large intestine	SW1417	9.7
Large intestine	SW1463	9
Large intestine	SW403	9.4
Large intestine	SW480	9.8
Large intestine	SW48	9.7
Large intestine	SW620	9.9
Large intestine	SW837	10.1
Large intestine	SW948	8.3
Large intestine	T84	9.9
Liver	ALEXANDERCELLS	8.2
Liver	C3A	9.3
Liver	HEP3B217	9.1
Liver	HEPG2	9
Liver	HLE	10
Liver	HLF	9.6
Liver	HUH1	9.5
Liver	HUH6	9.4
Liver	HUH7	9.3
Liver	JHH1	9.5
Liver	JHH2	6.9
Liver	JHH4	9.2
Liver	JHH5	8.8
Liver	JHH6	8
Liver	JHH7	9.9
Liver	LI7	9.7
Liver	PLCPRF5	8.5
Liver	SKHEP1	8.7
Liver	SNU182	8.1
Liver	SNU387	7.5
Liver	SNU398	10.5
Liver	SNU423	8.9
Liver	SNU449	9.4
Liver	SNU475	7.7
Liver	SNU761	7
Liver	SNU878	8.5
Liver	SNU886	8.2
Lung	A549	9.6
Lung	ABC1	10.1
Lung	BEN	5.6
Lung	CAL12T	10.2
Lung	CALU1	8.8
Lung	CALU3	8.2
Lung	CALU6	9.7
Lung	CHAGOK1	8.4
Lung	COLO668	8.7
Lung	COLO699	8.1
Lung	CORL105	9.3
Lung	CORL23	9
Lung	CORL24	8.7
Lung	CORL279	8.7
Lung	CORL311	8.2
Lung	CORL47	7.6
Lung	CORL51	8.3
Lung	CORL88	9.5
Lung	CORL95	7.7
Lung	CPCN	9.4
Lung	DMS114	10.3
Lung	DMS153	10.4
Lung	DMS273	9.1
Lung	DMS454	8.6
Lung	DMS53	9.2
Lung	DMS79	10.2
Lung	DV90	7.9
Lung	EBC1	10.5
Lung	EPLC272H	9.8
Lung	HARA	9.8
Lung	HCC1171	9
Lung	HCC1195	9.2
Lung	HCC15	9.5
Lung	HCC2279	8.1
Lung	HCC2935	8.7
Lung	HCC33	9.4
Lung	HCC366	9.8
Lung	HCC4006	9.1
Lung	HCC44	8.3
Lung	HCC78	9.7
Lung	HCC827	9.3
Lung	HCC95	9.8
Lung	HLC1	8.1
Lung	HLFA	8.4
Lung	HS229T	9.4
Lung	HS618T	9.2
Lung	IALM	8.6
Lung	KNS62	9
Lung	LC1F	9
Lung	LC1SQSF	9.3
Lung	LCLC103H	8.2
Lung	LCLC97TM1	8.5
Lung	LK2	9.2
Lung	LOUNH91	7.6
Lung	LU65	10
Lung	LU99	9.9
Lung	LUDLU1	9.1
Lung	LXF289	7.6
Lung	MORCPR	8.8
Lung	NCIH1048	8.9
Lung	NCIH1092	9
Lung	NCIH1105	9.8
Lung	NCIH1155	9.2
Lung	NCIH1184	10.2
Lung	NCIH1299	8.4
Lung	NCIH1339	8.9
Lung	NCIH1341	8.5
Lung	NCIH1355	9
Lung	NCIH1373	9.4
Lung	NCIH1385	6.5
Lung	NCIH1395	7.7
Lung	NCIH1435	9.7
Lung	NCIH1436	9.5
Lung	NCIH1437	9.1
Lung	NCIH146	9
Lung	NCIH1563	8.5
Lung	NCIH1568	8.7
Lung	NCIH1573	9.4
Lung	NCIH1581	10.1
Lung	NCIH1618	9.8
Lung	NCIH1623	8.3
Lung	NCIH1648	9.3
Lung	NCIH1650	9.9
Lung	NCIH1651	9.4
Lung	NCIH1666	8.2
Lung	NCIH1693	9.9
Lung	NCIH1694	9.8
Lung	NCIH1703	10
Lung	NCIH1734	9.8
Lung	NCIH1755	9
Lung	NCIH1781	9.7
Lung	NCIH1792	8.5
Lung	NCIH1793	9.3
Lung	NCIH1836	9.8
Lung	NCIH1838	9.5
Lung	NCIH1869	9.3
Lung	NCIH1876	9.5
Lung	NCIH1915	9.8
Lung	NCIH1930	10.1
Lung	NCIH1944	8.7
Lung	NCIH1963	8.4
Lung	NCIH196	8.4
Lung	NCIH1975	8.8
Lung	NCIH2009	9.6
Lung	NCIH2023	9.7
Lung	NCIH2029	9.7
Lung	NCIH2030	8.3
Lung	NCIH2066	8.6
Lung	NCIH2081	8.5
Lung	NCIH2085	9.5
Lung	NCIH2087	9.9
Lung	NCIH209	9.7
Lung	NCIH2106	8.7
Lung	NCIH2110	8.9
Lung	NCIH211	8.6
Lung	NCIH2122	8.1
Lung	NCIH2126	8.1
Lung	NCIH2141	10.2
Lung	NCIH2170	9.3
Lung	NCIH2171	8.2
Lung	NCIH2172	8.9
Lung	NCIH2196	8.6
Lung	NCIH2227	9.2
Lung	NCIH2228	9.4
Lung	NCIH226	9
Lung	NCIH2286	9.8
Lung	NCIH2291	9.2
Lung	NCIH2342	9
Lung	NCIH2347	9.5
Lung	NCIH23	9.1
Lung	NCIH2405	8.7
Lung	NCIH2444	8.3
Lung	NCIH292	9.3
Lung	NCIH322	8.5
Lung	NCIH3255	8.6
Lung	NCIH358	9.4
Lung	NCIH441	8.7
Lung	NCIH446	8.2
Lung	NCIH460	9
Lung	NCIH510	9.6
Lung	NCIH520	10.1
Lung	NCIH522	8.8
Lung	NCIH524	9.4
Lung	NCIH526	8.8
Lung	NCIH596	9
Lung	NCIH647	9
Lung	NCIH650	8.4
Lung	NCIH661	9.3
Lung	NCIH69	9.9
Lung	NCIH727	9.2
Lung	NCIH810	8.8
Lung	NCIH82	9.8
Lung	NCIH838	9.9
Lung	NCIH841	9.2
Lung	NCIH854	6.5
Lung	NCIH889	8.7
Lung	PC14	7.7
Lung	RERFLCAD1	8.9
Lung	RERFLCAD2	9.2
Lung	RERFLCAI	9.3
Lung	RERFLCKJ	8.8
Lung	RERFLCMS	8.5
Lung	RERFLCSQ1	9
Lung	SBC5	7.9
Lung	SCLC21H	7.4
Lung	SHP77	9.5
Lung	SKLU1	8.7
Lung	SKMES1	8.4
Lung	SQ1	8.8
Lung	SW1271	8.7
Lung	SW1573	9.3
Lung	SW900	9.1
Lung	VMRCLCD	8.2
Lung	VMRCLCP	10.1
Oesophagus	COLO680N	7.8
Oesophagus	ECGI10	7.1
Oesophagus	KYSE140	9.7
Oesophagus	KYSE150	9.7
Oesophagus	KYSE180	10.2
Oesophagus	KYSE270	9
Oesophagus	KYSE30	7.1
Oesophagus	KYSE410	8.9
Oesophagus	KYSE450	8.7
Oesophagus	KYSE510	9.7
Oesophagus	KYSE520	8.6
Oesophagus	KYSE70	7.3
Oesophagus	OE19	8.6
Oesophagus	OE33	10.3
Oesophagus	TE10	9.5
Oesophagus	TE11	9.2
Oesophagus	TE14	8.7
Oesophagus	TE15	9.6
Oesophagus	TE1	9.7
Oesophagus	TE4	10.1
Oesophagus	TE5	10
Oesophagus	TE6	9.5
Oesophagus	TE8	8.9
Oesophagus	TE9	9.1
Oesophagus	TT	8.6
Ovary	59M	7.5
Ovary	A2780	9.8
Ovary	CAOV3	9.6
Ovary	CAOV4	7
Ovary	COLO704	10.2
Ovary	COV318	8.8
Ovary	COV362	9.4
Ovary	COV434	9.1
Ovary	COV504	9
Ovary	COV644	7.9
Ovary	EFO21	7.1
Ovary	EFO27	8.2
Ovary	ES2	8.9
Ovary	FUOV1	10.3
Ovary	HEYA8	9.9
Ovary	HS571T	6.7
Ovary	IGROV1	9.5
Ovary	JHOC5	8.9
Ovary	JHOM1	8.1
Ovary	JHOM2B	9.2
Ovary	JHOS2	9.5
Ovary	JHOS4	10.6
Ovary	KURAMOCHI	7.2
Ovary	MCAS	10
Ovary	NIHOVCAR3	8.8
Ovary	OAW28	9.1
Ovary	OAW42	9.7
Ovary	OC314	9.8
Ovary	OC316	10.2
Ovary	ONCODG1	8.5
Ovary	OV56	6.6
Ovary	OV7	8.1
Ovary	OV90	8.2
Ovary	OVCAR4	8.5
Ovary	OVCAR8	9.7
Ovary	OVISE	9.6
Ovary	OVK18	9.3
Ovary	OVKATE	8.3
Ovary	OVMANA	8.7
Ovary	OVSAHO	8.5
Ovary	OVTOKO	9.9
Ovary	RMGI	6.3
Ovary	RMUGS	9.3
Ovary	SKOV3	7.8
Ovary	SNU119	9.1
Ovary	SNU840	9.4
Ovary	SNU8	7.5
Ovary	TOV112D	9.2
Ovary	TOV21G	9.4
Ovary	TYKNU	9.5
Pancreas	ASPC1	7.6
Pancreas	BXPC3	8.9
Pancreas	CAPAN1	8.9
Pancreas	CAPAN2	9.9
Pancreas	CFPAC1	7.8
Pancreas	DANG	10.4
Pancreas	HPAC	9.1
Pancreas	HPAFII	8.2
Pancreas	HS766T	9.4
Pancreas	HUPT3	9
Pancreas	HUPT4	9.2
Pancreas	KCIMOH1	8.8
Pancreas	KLM1	9.4
Pancreas	KP2	8.8
Pancreas	KP3	8.6
Pancreas	KP4	9.9
Pancreas	L33	9.2
Pancreas	MIAPACA2	9.6
Pancreas	PANC0203	9.2
Pancreas	PANC0213	7.7
Pancreas	PANC0327	9.7
Pancreas	PANC0403	9.1
Pancreas	PANC0504	9.8
Pancreas	PANC0813	9.6
Pancreas	PANC1005	9.9
Pancreas	PANC1	10.3
Pancreas	PATU8902	10.1
Pancreas	PATU8988S	9.6
Pancreas	PATU8988T	10.2
Pancreas	PK1	10.1
Pancreas	PK45H	9.2
Pancreas	PK59	8.6
Pancreas	PL45	10.4
Pancreas	PSN1	9.4
Pancreas	QGP1	7.6
Pancreas	SNU213	9.3
Pancreas	SNU324	7.5
Pancreas	SNU410	7.9
Pancreas	SU8686	6.1
Pancreas	SUIT2	9.9
Pancreas	SW1990	9.6
Pancreas	T3M4	9.2
Pancreas	TCCPAN2	7.7
Pancreas	YAPC	10
Pleura	ACCMESO1	8.5
Pleura	DM3	6
Pleura	ISTMES1	9.1
Pleura	ISTMES2	9.9
Pleura	JL1	7.6
Pleura	MPP89	9.2
Pleura	MSTO211H	8.5
Pleura	NCIH2052	9.7
Pleura	NCIH2452	8.9
Pleura	NCIH28	9.4
Prostate	22RV1	9.8
Prostate	DU145	9.5
Prostate	LNCAPCLONEFGC	7.5
Prostate	MDAPCA2B	8
Prostate	NCIH660	8.9
Prostate	PC3	8.1
Prostate	VCAP	9.3
Salivary gland	A253	8.9
Salivary gland	YD15	10.2
Skin	A101D	8.2
Skin	A2058	8.4
Skin	A375	9.3
Skin	C32	8.8
Skin	CHL1	8.1
Skin	CJM	6.6
Skin	COLO679	8.9
Skin	COLO741	8.3
Skin	COLO783	8
Skin	COLO792	8.5
Skin	COLO800	7.8
Skin	COLO818	7.7
Skin	COLO829	6.9
Skin	COLO849	8.5
Skin	G361	8.4
Skin	GRM	7.9
Skin	HMCB	8.6
Skin	HS294T	7.8
Skin	HS600T	8.2
Skin	HS688AT	6.7
Skin	HS695T	8.2
Skin	HS839T	8.8
Skin	HS852T	9.7
Skin	HS895T	7.9
Skin	HS934T	8.5
Skin	HS936T	9.5
Skin	HS939T	8.8
Skin	HS940T	7.4
Skin	HS944T	8.6
Skin	HT144	8.8
Skin	IGR1	7.5
Skin	IGR37	8.5
Skin	IGR39	9.2
Skin	IPC298	8.8
Skin	K029AX	8
Skin	LOXIMVI	8.6
Skin	MALME3M	7.2
Skin	MDAMB435S	8.9
Skin	MELHO	8.2
Skin	MELJUSO	8.2
Skin	MEWO	8.8
Skin	RPMI7951	9.3
Skin	RVH421	8.6
Skin	SH4	8.5
Skin	SKMEL1	8.8
Skin	SKMEL24	8.3
Skin	SKMEL28	8.8
Skin	SKMEL2	8.9
Skin	SKMEL30	9
Skin	SKMEL31	7.3
Skin	SKMEL3	8
Skin	SKMEL5	8.2
Skin	UACC257	9
Skin	UACC62	8.1
Skin	WM115	7.5
Skin	WM1799	8.5
Skin	WM2664	8.4
Skin	WM793	8.4
Skin	WM88	7.8
Skin	WM983B	8.3
Small intestine	HUTU80	9.7
Soft tissue	A204	9.1
Soft tissue	G401	10.1
Soft tissue	G402	9.7
Soft tissue	GCT	8.7
Soft tissue	HS729	8.8
Soft tissue	HT1080	9
Soft tissue	KYM1	10.4
Soft tissue	MESSA	8.9
Soft tissue	RD	9.5
Soft tissue	RH30	8.4
Soft tissue	RH41	8.2
Soft tissue	RKN	8.3
Soft tissue	S117	8.3
Soft tissue	SJRH30	8.9
Soft tissue	SKLMS1	8.3
Soft tissue	SKUT1	9.4
Soft tissue	TE125T	7.7
Soft tissue	TE159T	7.3
Soft tissue	TE441T	9.3
Soft tissue	TE617T	9.6
Stomach	2313287	7.7
Stomach	AGS	10.2
Stomach	AZ521	9.7
Stomach	ECC10	8.8
Stomach	ECC12	9.7
Stomach	FU97	9
Stomach	GCIY	9.1
Stomach	GSS	9.3
Stomach	GSU	9.2
Stomach	HGC27	10.4
Stomach	HS746T	9.2
Stomach	HUG1N	10.3
Stomach	IM95	8.9
Stomach	KATOIII	9.2
Stomach	KE39	9
Stomach	LMSU	9.4
Stomach	MKN1	8.2
Stomach	MKN45	10
Stomach	MKN74	8.5
Stomach	MKN7	8.7
Stomach	NCCSTCK140	7.3
Stomach	NCIN87	9.6
Stomach	NUGC2	7.3
Stomach	NUGC3	9.1
Stomach	NUGC4	8.1
Stomach	OCUM1	9.4
Stomach	RERFGC1B	9.6
Stomach	SH10TC	9
Stomach	SNU16	8.6
Stomach	SNU1	9.1
Stomach	SNU216	8.6
Stomach	SNU520	10.2
Stomach	SNU5	9.7
Stomach	SNU601	8.3
Stomach	SNU620	8.9
Stomach	SNU668	9.4
Stomach	SNU719	8.4
Stomach	TGBC11TKB	7.6
Thyroid	8305C	7.9
Thyroid	8505C	8.6
Thyroid	BCPAP	6
Thyroid	BHT101	7.3
Thyroid	CAL62	9.8
Thyroid	CGTHW1	8.6
Thyroid	FTC133	8
Thyroid	FTC238	9.3
Thyroid	ML1	8.2
Thyroid	SW579	9.1
Thyroid	TT2609C02	9.3
Thyroid	TT	7.7
Upper aerodigestive tract	BHY	8.9
Upper aerodigestive tract	BICR16	7
Upper aerodigestive tract	BICR18	9
Upper aerodigestive tract	BICR22	6
Upper aerodigestive tract	BICR31	7.2
Upper aerodigestive tract	BICR56	5.3
Upper aerodigestive tract	BICR6	8.2
Upper aerodigestive tract	CAL27	8.8
Upper aerodigestive tract	CAL33	7.1
Upper aerodigestive tract	DETROIT562	9.7
Upper aerodigestive tract	FADU	10.3
Upper aerodigestive tract	HS840T	8.9
Upper aerodigestive tract	HSC2	8.6
Upper aerodigestive tract	HSC3	10
Upper aerodigestive tract	HSC4	8.7
Upper aerodigestive tract	PECAPJ15	8.7
Upper aerodigestive tract	PECAPJ34CLONEC12	9.4
Upper aerodigestive tract	PECAPJ41CLONED2	7.4
Upper aerodigestive tract	PECAPJ49	8.3
Upper aerodigestive tract	SCC15	7.4
Upper aerodigestive tract	SCC25	8.4
Upper aerodigestive tract	SCC4	8.5
Upper aerodigestive tract	SCC9	8.4
Upper aerodigestive tract	SNU1076	7
Upper aerodigestive tract	SNU1214	8.1
Upper aerodigestive tract	SNU46	9.6
Upper aerodigestive tract	SNU899	9
Upper aerodigestive tract	YD10B	9
Upper aerodigestive tract	YD38	8.9
Upper aerodigestive tract	YD8	8.4
Urinary tract	5637	8.2
Urinary tract	639V	9.5
Urinary tract	647V	8.5
Urinary tract	BC3C	9.3
Urinary tract	BFTC905	8.2
Urinary tract	CAL29	9.5
Urinary tract	HS172T	7.6
Urinary tract	HT1197	8.5
Urinary tract	HT1376	7.6
Urinary tract	J82	8.6
Urinary tract	JMSU1	8.6
Urinary tract	KMBC2	9
Urinary tract	KU1919	9.2
Urinary tract	RT11284	9.5
Urinary tract	RT112	9.1
Urinary tract	RT4	10.8
Urinary tract	SCABER	9.1
Urinary tract	SW1710	7.7
Urinary tract	SW780	9.6
Urinary tract	T24	9.1
Urinary tract	TCCSUP	7.4
Urinary tract	UMUC1	7.8
Urinary tract	UMUC3	10.2
Urinary tract	VMCUB1	9.3

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	1.5
Adrenal gland	1.6
Appendix	9.1
Bone marrow	10.6
Breast	3.8
Cerebral cortex	1.6
Cervix, uterine	2.7
Colon	4.3
Duodenum	3.7
Endometrium	4.9
Epididymis	1.8
Esophagus	4
Fallopian tube	2.5
Gallbladder	3.3
Heart muscle	0.2
Kidney	2
Liver	0.9
Lung	2.1
Lymph node	15.1
Ovary	1.9
Pancreas	0.1
Parathyroid gland	4.1
Placenta	5.9
Prostate	2.6
Rectum	5.9
Salivary gland	0.5
Seminal vesicle	1.4
Skeletal muscle	0.1
Skin	6.3
Small intestine	4.1
Smooth muscle	3.2
Spleen	3.8
Stomach	3.5
Testis	23.9
Thyroid gland	1.7
Tonsil	12
Urinary bladder	4.5

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
17611626	overexpression	Melanoma	Further analysis of expression signatures associated with melanoma progression using functional annotations categorized these transcripts into three classes of genes: 1) Upregulation of activators of cell cycle progression, DNA replication and repair (CDCA2, NCAPH, NCAPG, NCAPG2, PBK, NUSAP1, BIRC5, ESCO2, HELLS, MELK, GINS1, GINS4, RAD54L, TYMS, and DHFR), 2) Loss of genes associated with cellular adhesion and melanocyte differentiation (CDH3, CDH1, c-KIT, PAX3, CITED1/MSG-1, TYR, MELANA, MC1R, and OCA2), 3) Upregulation of genes associated with resistance to apoptosis (BIRC5/survivin).
27191985	overexpression	Prostate Carcinoma	ZIC5 mRNA was up-regulated 17 fold (p = 8.4E-07), ZIC2 8 fold (p = 1.3E-05) and HELLS 2 fold (p = 0.006) in GG3 glands derived from GS 4 + 3 = 7. HELLS expression of ≥ 1% occurred in 10% GS < 7, 17% GS 7 and 43% GS >7 prostate cancer (p < 0.001).
25338120	overexpression	Retinoblastoma	Using orthotopic human xenografts, we validated that upregulation of HELLS and UHRF1 is essential for the tumor phenotype.
22157815	overexpression	Prostate Carcinoma	Strikingly, just as E2F3, HELLS is overexpressed in human tumours including prostate cancer, indicating that either factor may contribute to the malignant progression of tumours.
22109759	overexpression	Oropharyngeal Squamous Cell Carcinoma	HELLS FOXM1, CEP55, and HELLS were all overexpressed in oropharyngeal squamous cell carcinoma tissue when compared to normal tissue.
20400365	overexpression	Head and Neck Squamous Cell Carcinoma	Low level of HELLS expression was detected in the basal cell layer of the normal oral mucosa, moderate level was seen in dysplasia and high levels in both HNSCC and LnMet.
28069330	Overexpression	Renal Cell Carcinoma	High mRNA levels of TOP2A, HELLS, ATAD2, and TET3 are independent predictors of poor outcome in RCC patients and may be used for individual risk-adapted therapy in the future.

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.126	0.011	40.6	52	7.4	Loss
BRCA	Breast invasive carcinoma	1075	0.167	3.64e-08	29.3	62.5	8.2	Neutral
CESC	Cervical and endocervical cancers	292	0.298	2.09e-07	29.5	64.4	6.2	Neutral
COAD	Colon adenocarcinoma	449	0.232	6.41e-07	22.9	73.7	3.3	Neutral
ESCA	Esophageal carcinoma	183	0.156	0.035	36.1	50.8	13.1	Loss
GBM	Glioblastoma multiforme	147	-0.016	0.845	91.8	8.2	0	Loss
HNSC	Head and Neck squamous cell carcinoma	514	0.115	0.00903	26.3	67.3	6.4	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.179	3.84e-05	18.1	79.8	2.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.004	0.943	6.2	91	2.8	Neutral
LAML	Acute Myeloid Leukemia	166	0.112	0.15	0.6	97.6	1.8	Neutral
LGG	Brain Lower Grade Glioma	513	-0.228	1.87e-07	22.2	77.4	0.4	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.003	0.948	25.8	64	10.2	Neutral
LUAD	Lung adenocarcinoma	512	-0.007	0.879	28.3	57.4	14.3	Neutral
LUSC	Lung squamous cell carcinoma	498	0.166	2e-04	52.2	40.6	7.2	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.336	2.49e-09	44.7	38.7	16.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.132	0.0808	18.6	74.6	6.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.334	1.38e-05	1.2	91.4	7.4	Neutral
PRAD	Prostate adenocarcinoma	491	0.15	0.000835	17.5	80.9	1.6	Neutral
READ	Rectum adenocarcinoma	164	0.18	0.0215	29.3	68.3	2.4	Neutral
SARC	Sarcoma	255	0.049	0.436	51.8	42.4	5.9	Loss
SKCM	Skin Cutaneous Melanoma	367	0.333	5.97e-11	62.1	36.2	1.6	Loss
STAD	Stomach adenocarcinoma	413	0.183	0.000185	24.2	63.7	12.1	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.211	0.00953	44	48.7	7.3	Loss
THCA	Thyroid carcinoma	497	0.137	0.00217	1.6	98	0.4	Neutral
THYM	Thymoma	119	0.214	0.0197	3.4	95	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.165	0.000122	15.1	65.4	19.6	Neutral

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.066	0.172	17	408	-0.001	0.618	NS/NA
BRCA	Breast invasive carcinoma	-0.077	0.0226	83	785	0.001	0.261	NS/NA
CESC	Cervical and endocervical cancers	-0.185	0.00113	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.161	0.00423	19	297	0.003	0.0363	NS/NA
ESCA	Esophageal carcinoma	-0.142	0.0487	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	0.015	0.905	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.027	0.533	20	522	-0.004	0.354	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.14	0.00953	24	319	0.007	6.46e-14	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.081	0.162	23	275	0.004	0.292	NS/NA
LAML	Acute Myeloid Leukemia	-0.116	0.132	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.028	0.524	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.193	8.1e-05	41	373	-0.033	2.46e-05	NS/NA
LUAD	Lung adenocarcinoma	-0.097	0.0339	21	456	0.004	0.579	NS/NA
LUSC	Lung squamous cell carcinoma	-0.019	0.719	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.367	0.336	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.16	0.0301	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.134	0.0681	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.132	0.00225	35	498	0.002	0.596	NS/NA
READ	Rectum adenocarcinoma	-0.189	0.0586	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.033	0.591	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.242	1.08e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.271	1.28e-07	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.453	4.35e-09	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.127	0.00263	50	509	-0.001	0.0103	NS/NA
THYM	Thymoma	-0.241	0.00761	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.176	0.000139	34	431	-0.003	0.3	NS/NA

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	0	Not detected
Appendix	2	Medium
Bone marrow	2	Medium
Breast	0	Not detected
Bronchus	1	Low
Caudate	1	Low
Cerebellum	0	Not detected
Cerebral cortex	0	Not detected
Cervix, uterine	1	Low
Colon	1	Low
Duodenum	2	Medium
Endometrium	2	Medium
Epididymis	0	Not detected
Esophagus	2	Medium
Fallopian tube	2	Medium
Gallbladder	0	Not detected
Heart muscle	0	Not detected
Hippocampus	1	Low
Kidney	0	Not detected
Liver	0	Not detected
Lung	1	Low
Lymph node	3	High
Nasopharynx	0	Not detected
Oral mucosa	2	Medium
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	2	Medium
Prostate	0	Not detected
Rectum	2	Medium
Salivary gland	1	Low
Seminal vesicle	0	Not detected
Skeletal muscle	0	Not detected
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	0	Not detected
Soft tissue	0	Not detected
Spleen	2	Medium
Stomach	2	Medium
Testis	2	Medium
Thyroid gland	0	Not detected
Tonsil	3	High
Urinary bladder	0	Not detected
Vagina	2	Medium

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.0879	NS	24476821
BRCA	Breast invasive carcinoma	521	1.37e-35	Significant	23000897
COAD	Colon adenocarcinoma	149	0.115	NS	22810696
GBM	Glioblastoma multiforme	157	0.00883	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	9.6e-10	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.14	NS	26536169
LGG	Brain Lower Grade Glioma	513	5.84e-06	Significant	26824661
LUAD	Lung adenocarcinoma	230	1.14e-16	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	2.84e-05	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.33e-05	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.353	NS	26544944
READ	Rectum adenocarcinoma	67	0.336	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0147	Significant	26091043
STAD	Stomach adenocarcinoma	277	4.16e-13	Significant	25079317
THCA	Thyroid carcinoma	391	5.02e-13	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.0131	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.853	0.453	NS
BRCA	Breast invasive carcinoma	1079	0.964	0.87	NS
CESC	Cervical and endocervical cancers	291	0.5	0.0462	Longer
COAD	Colon adenocarcinoma	439	0.658	0.15	NS
ESCA	Esophageal carcinoma	184	1.227	0.583	NS
GBM	Glioblastoma multiforme	158	0.884	0.633	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.811	0.31	NS
KIRC	Kidney renal clear cell carcinoma	531	1.312	0.179	NS
KIRP	Kidney renal papillary cell carcinoma	287	3.045	0.00525	Shorter
LAML	Acute Myeloid Leukemia	149	1.46	0.218	NS
LGG	Brain Lower Grade Glioma	511	2.987	1.9e-05	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.762	0.0215	Shorter
LUAD	Lung adenocarcinoma	502	1.637	0.0181	Shorter
LUSC	Lung squamous cell carcinoma	494	0.643	0.0237	Longer
OV	Ovarian serous cystadenocarcinoma	303	1.196	0.392	NS
PAAD	Pancreatic adenocarcinoma	177	2.009	0.0261	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	4.096	0.171	NS
PRAD	Prostate adenocarcinoma	497	9.443	0.0123	Shorter
READ	Rectum adenocarcinoma	159	0.439	0.201	NS
SARC	Sarcoma	259	2.309	0.0142	Shorter
SKCM	Skin Cutaneous Melanoma	459	1.072	0.72	NS
STAD	Stomach adenocarcinoma	388	0.636	0.0545	NS
TGCT	Testicular Germ Cell Tumors	134	0.982	0.99	NS
THCA	Thyroid carcinoma	500	0.486	0.396	NS
THYM	Thymoma	119	0	0.017	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.13	0.702	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.001	0.986	NS
BRCA	Breast invasive carcinoma	1071	0.004	0.904	NS
CESC	Cervical and endocervical cancers	167	0.01	0.898	NS
COAD	Colon adenocarcinoma	445	-0.174	0.000233	Lower
ESCA	Esophageal carcinoma	162	0.076	0.336	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.025	0.591	NS
KIRC	Kidney renal clear cell carcinoma	531	0.048	0.268	NS
KIRP	Kidney renal papillary cell carcinoma	260	0.304	5.95e-07	Higher
LIHC	Liver hepatocellular carcinoma	347	0.127	0.0178	Higher
LUAD	Lung adenocarcinoma	507	0.156	0.000434	Higher
LUSC	Lung squamous cell carcinoma	497	0.124	0.00577	Higher
OV	Ovarian serous cystadenocarcinoma	302	-0.067	0.242	NS
PAAD	Pancreatic adenocarcinoma	176	0.104	0.172	NS
READ	Rectum adenocarcinoma	156	-0.016	0.846	NS
SKCM	Skin Cutaneous Melanoma	410	-0.09	0.0678	NS
STAD	Stomach adenocarcinoma	392	-0.021	0.675	NS
TGCT	Testicular Germ Cell Tumors	81	0.02	0.858	NS
THCA	Thyroid carcinoma	499	-0.068	0.128	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.125	0.0051	Higher

> Grade

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Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.02	0.742	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.245	2.9e-08	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.055	0.212	NS
LGG	Brain Lower Grade Glioma	514	0.303	2.15e-12	Higher
LIHC	Liver hepatocellular carcinoma	366	0.318	4.77e-10	Higher
OV	Ovarian serous cystadenocarcinoma	296	0.134	0.0214	Higher
PAAD	Pancreatic adenocarcinoma	176	0.278	0.000186	Higher
STAD	Stomach adenocarcinoma	406	-0.041	0.414	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.277	7.88e-11	Higher

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for HELLS.

Summary
Symbol	HELLS
Name	helicase, lymphoid-specific
Aliases	PASG; SMARCA6; Nbla10143; SWI/SNF2-related, matrix-associated, actin-dependent regulator of chromatin, subfa ......
Location	10q23.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

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PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
22157815	Prostate Carcinoma	partner	E2F3B	coorperation	Here, E2F3B interaction partners were identified by mass spectrometric analysis. We show that the SNF2-like helicase HELLS interacts with E2F3A in vivo and cooperates with its oncogenic functions. Depletion of HELLS severely perturbs the induction of E2F-target genes, hinders cell-cycle re-entry and growth.