Summary
Symbol	IDH1
Name	isocitrate dehydrogenase (NADP(+)) 1, cytosolic
Aliases	HEL-216; HEL-S-26; IDCD; IDPC; PICD; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isoc ......
Location	2q34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Gene Ontology [ TOP ]
Biological Process	GO:0006091 generation of precursor metabolites and energy GO:0006097 glyoxylate cycle GO:0006099 tricarboxylic acid cycle GO:0006102 isocitrate metabolic process GO:0006103 2-oxoglutarate metabolic process GO:0006575 cellular modified amino acid metabolic process GO:0006644 phospholipid metabolic process GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006739 NADP metabolic process GO:0006740 NADPH regeneration GO:0006749 glutathione metabolic process GO:0006790 sulfur compound metabolic process GO:0006979 response to oxidative stress GO:0007548 sex differentiation GO:0008406 gonad development GO:0008585 female gonad development GO:0008654 phospholipid biosynthetic process GO:0009060 aerobic respiration GO:0009395 phospholipid catabolic process GO:0009894 regulation of catabolic process GO:0015980 energy derivation by oxidation of organic compounds GO:0016042 lipid catabolic process GO:0019216 regulation of lipid metabolic process GO:0019362 pyridine nucleotide metabolic process GO:0031329 regulation of cellular catabolic process GO:0043648 dicarboxylic acid metabolic process GO:0044242 cellular lipid catabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0045137 development of primary sexual characteristics GO:0045333 cellular respiration GO:0046434 organophosphate catabolic process GO:0046487 glyoxylate metabolic process GO:0046496 nicotinamide nucleotide metabolic process GO:0046545 development of primary female sexual characteristics GO:0046660 female sex differentiation GO:0046890 regulation of lipid biosynthetic process GO:0048545 response to steroid hormone GO:0048608 reproductive structure development GO:0050994 regulation of lipid catabolic process GO:0051186 cofactor metabolic process GO:0060696 regulation of phospholipid catabolic process GO:0061458 reproductive system development GO:0071071 regulation of phospholipid biosynthetic process GO:0072350 tricarboxylic acid metabolic process GO:0072524 pyridine-containing compound metabolic process GO:1903725 regulation of phospholipid metabolic process
Molecular Function	GO:0000287 magnesium ion binding GO:0004448 isocitrate dehydrogenase activity GO:0004450 isocitrate dehydrogenase (NADP+) activity GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0045296 cadherin binding GO:0048037 cofactor binding GO:0050661 NADP binding GO:0050662 coenzyme binding GO:0050839 cell adhesion molecule binding GO:0051287 NAD binding GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component	GO:0005777 peroxisome GO:0005782 peroxisomal matrix GO:0005913 cell-cell adherens junction GO:0031907 microbody lumen GO:0042579 microbody GO:0044438 microbody part GO:0044439 peroxisomal part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04146 Peroxisome hsa00020 Citrate cycle (TCA cycle) hsa00480 Glutathione metabolism hsa01100 Metabolic pathways hsa01200 Carbon metabolism hsa01210 2-Oxocarboxylic acid metabolism hsa01230 Biosynthesis of amino acids
Reactome	R-HSA-2978092: Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-1643685: Disease R-HSA-5668914: Diseases of metabolism R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-389542: NADPH regeneration R-HSA-6798695: Neutrophil degranulation R-HSA-390918: Peroxisomal lipid metabolism