Summary | |
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Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway |
Domain |
PF12998 Inhibitor of growth proteins N-terminal histone-binding |
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Function |
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). |
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Classification |
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Biological Process |
GO:0006260 DNA replication GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0007050 cell cycle arrest GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0042770 signal transduction in response to DNA damage GO:0042772 DNA damage response, signal transduction resulting in transcription GO:0043543 protein acylation GO:0043966 histone H3 acetylation GO:0043967 histone H4 acetylation GO:0043981 histone H4-K5 acetylation GO:0043982 histone H4-K8 acetylation GO:0043983 histone H4-K12 acetylation GO:0045786 negative regulation of cell cycle GO:0045926 negative regulation of growth GO:0072331 signal transduction by p53 class mediator |
Molecular Function |
GO:0003713 transcription coactivator activity GO:0035064 methylated histone binding GO:0042393 histone binding |
Cellular Component |
GO:0000123 histone acetyltransferase complex GO:0031248 protein acetyltransferase complex GO:1902493 acetyltransferase complex |
KEGG | - |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones |
Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining |
There is no record. |
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Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Post-translational modification (PTM) |
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Showing 1 to 7 of 7 rows |
Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change |
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Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Somatic copy number alteration in primary tomur tissue |
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Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Methylation level in the promoter region of CR |
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Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Primary tumor tissue from TCGA > Normal tumor tissue from HPA |
There is no record. |
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Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade |
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Showing 1 to 9 of 9 rows |
Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data |
Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Drugs from DrugBank database |
There is no record for ING4. |
Summary | |
---|---|
Symbol | ING4 |
Name | inhibitor of growth family member 4 |
Aliases | p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ...... |
Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Cancer Gene Databases | ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes) |
Content |
> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining |
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