Browse ING4 in pancancer

Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF12998 Inhibitor of growth proteins N-terminal histone-binding
Function

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).

Classification
Class Modification Substrate Product PubMed
Histone modification read # H3K4me3 # 18381289
> Gene Ontology
 
Biological Process GO:0006260 DNA replication
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050 cell cycle arrest
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0042770 signal transduction in response to DNA damage
GO:0042772 DNA damage response, signal transduction resulting in transcription
GO:0043543 protein acylation
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043983 histone H4-K12 acetylation
GO:0045786 negative regulation of cell cycle
GO:0045926 negative regulation of growth
GO:0072331 signal transduction by p53 class mediator
Molecular Function GO:0003713 transcription coactivator activity
GO:0035064 methylated histone binding
GO:0042393 histone binding
Cellular Component GO:0000123 histone acetyltransferase complex
GO:0031248 protein acetyltransferase complex
GO:1902493 acetyltransferase complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-3214847: HATs acetylate histones
Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
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COSMIC ID
CDS change
AA change
Mutation Type
Anatomical Site
COSM6000404c.18T>Gp.Y6*Substitution - NonsenseProstate
COSM3872301c.587C>Tp.T196ISubstitution - MissenseSkin
COSM4633725c.326C>Tp.A109VSubstitution - MissenseLarge_intestine
COSM549563c.730G>Cp.E244QSubstitution - MissenseLung
COSM344202c.498-2A>Tp.?UnknownLung
COSM3725426c.522A>Cp.S174SSubstitution - coding silentLung
COSM5935876c.38-6C>Tp.?UnknownSkin
COSM5375828c.315C>Tp.A105ASubstitution - coding silentSkin
COSM1676676c.695C>Ap.P232HSubstitution - MissenseLarge_intestine
COSM5805961c.494G>Tp.R165LSubstitution - MissenseLiver
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> Text Mining based Variations
 
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PMID
Variation
Cancer
Evidence
27527891loss of expression (mutation)Prostate CarcinomaFurthermore, loss of ING4 in the context of oncogenic mutations is required for prostate tumorigenesis.
20501848copy number loss; mutationBreast CarcinomaING4 is a candidate tumor suppressor gene that is deleted in 10% to 20% of human breast cancers and is mutated in various human cancer cell lines.
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Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
 Filter By:
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Uniprot ID
Position
Amino Acid
Description
Upstream Enzyme
Amino Acid Sequence Variant
Q9UNL4127KN6-acetyllysine-None detected
Q9UNL4129KN6-acetyllysine-None detected
Q9UNL4133RCitrulline-p.R133Q (cancer: COAD)
Q9UNL4146KN6-acetyllysine-None detected
Q9UNL4148KN6-acetyllysine-None detected
Q9UNL4156KN6-acetyllysine-None detected
Q9UNL4166RCitrulline-p.R166C (cancer: STAD); p.R166H (cancer: UCEC)
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Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
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Cancer
Full Name
# N
# T
Median (N)
Median (T)
LogFC
Adj. P
Status
BLCABladder urothelial carcinoma194084.7784.9030.2220.211NS
BRCABreast invasive carcinoma11211005.0945.041-0.0580.349NS
CESCCervical and endocervical cancers33065.4114.883NANANA
COADColon adenocarcinoma414594.684.236-0.4596.89e-07NS
ESCAEsophageal carcinoma111853.6913.407-0.3310.184NS
GBMGlioblastoma multiforme51665.3575.789NANANA
HNSCHead and Neck squamous cell carcinoma445224.2184.115-0.0770.557NS
KIRCKidney renal clear cell carcinoma725344.7974.980.170.00198NS
KIRPKidney renal papillary cell carcinoma322914.9175.320.4025.11e-05NS
LAMLAcute Myeloid Leukemia0173NA4.904NANANA
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> Cancer Cell Line Encyclopedia (CCLE)
 



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Tissue
Cell Line
Expression Level (Microarray)
Autonomic gangliaCHP1268.2
Autonomic gangliaCHP2127.2
Autonomic gangliaIMR327.6
Autonomic gangliaKELLY8
Autonomic gangliaKPNRTBM18.2
Autonomic gangliaKPNSI9S6.9
Autonomic gangliaKPNYN8
Autonomic gangliaMHHNB118.8
Autonomic gangliaNB16.9
Autonomic gangliaNH68.1
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> The Human Protein Atlas (HPA)
 


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Tissue
Expression Level (TPM)
Adipose tissue16.4
Adrenal gland24.5
Appendix20.8
Bone marrow7.5
Breast34.3
Cerebral cortex39.6
Cervix, uterine30.6
Colon19.7
Duodenum18.5
Endometrium41.9
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> Text Mining based Expression
 
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PMID
Expression
Cancer
Evidence
27527891loss of expression (mutation)Prostate CarcinomaFurthermore, loss of ING4 in the context of oncogenic mutations is required for prostate tumorigenesis.
27466989underexpressionCervical CarcinomaING4 expression was decreased significantly at mRNA and protein levels in the tissues of cervical cancer compared with paracarcinoma tissues.
26936485underexpressionColorectal CarcinomaWe demonstrated that both the low and high metastatic CRC cells exhibited a lower level of ING4 compared to the level in normal human colorectal mucous epithelial FHC cells.
26813279underexpressionAstrocytomaCompared with the non-tumor control, the mRNA expression level of ING4 gene decreased significantly in the astrocytoma (P<0.05).
26045800underexpressionColorectal CarcinomaING4 expression levels show negative correlation with the clinical stage, histological grade, and lymph node metastasis of colorectal cancer.
25792601underexpressionBreast CarcinomaSignificantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas.
25790869underexpressionBladder CarcinomaING4 protein and mRNA were significantly decreased in bladder cancer tissues.
24762396loss of expressionProstate CarcinomaING4 expression is lost in >60% of human primary prostate tumors.
24057236underexpressionGastric CarcinomaThe results demonstrated that expressions of ING4 mRNA and protein in gastric carcinoma tissues and cells were significantly lower than those in normal tissues and cells (P < 0.05).
23969950underexpression; loss of expressionGastric CarcinomaThe data showed that the expression of ING4 mRNA and protein was dramatically downregulated (or lost) in gastric carcinoma SGC7901/CDDP cells after CDDP-induced MDR phenotype and in the parental SGC7901 cells.
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Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
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Cancer
Full Name
# Sample
R
P
% Loss
% Neutral
% Gain
Status
BLCABladder urothelial carcinoma4040.3523.39e-1312.455.232.4Neutral
BRCABreast invasive carcinoma10750.5659.82e-921460.825.1Neutral
CESCCervical and endocervical cancers2920.442.84e-1515.165.419.5Neutral
COADColon adenocarcinoma4490.2116.43e-0610.966.122.9Neutral
ESCAEsophageal carcinoma1830.5666.5e-1718.648.133.3Neutral
GBMGlioblastoma multiforme1470.4161.64e-078.278.912.9Neutral
HNSCHead and Neck squamous cell carcinoma5140.3951.25e-207.460.931.7Neutral
KIRCKidney renal clear cell carcinoma5250.2833.99e-11175.823.2Neutral
KIRPKidney renal papillary cell carcinoma2880.5211.79e-210.760.139.2Gain
LAMLAcute Myeloid Leukemia1660.250.001181.898.20Neutral
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Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
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Cancer
Full Name
R
P
# N
# T
Delta beta (T vs N)
P value (T vs N)
Status
BLCABladder urothelial carcinoma-0.1750.00030617408-0.0050.0234NS/NA
BRCABreast invasive carcinoma-0.2616.41e-1583785-0.0030.00294NS/NA
CESCCervical and endocervical cancers-0.2481.13e-053306NANANS/NA
COADColon adenocarcinoma-0.1340.017119297-0.0010.985NS/NA
ESCAEsophageal carcinoma-0.3332.38e-069185NANANS/NA
GBMGlioblastoma multiforme-0.1990.112164NANANS/NA
HNSCHead and Neck squamous cell carcinoma-0.2012.44e-0620522-0.0070.0121NS/NA
KIRCKidney renal clear cell carcinoma-0.1930.000328243190.0020.267NS/NA
KIRPKidney renal papillary cell carcinoma-0.2884.86e-0723275-0.0010.726NS/NA
LAMLAcute Myeloid Leukemia0.0440.5710170NANANS/NA
Showing 1 to 10 of 26 rows rows per page
Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


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Tissue
Level
Level Name
Adrenal gland2Medium
Appendix1Low
Bone marrow1Low
Breast1Low
Bronchus1Low
Caudate0Not detected
Cerebellum0Not detected
Cerebral cortex1Low
Cervix, uterine2Medium
Colon0Not detected
Showing 1 to 10 of 44 rows rows per page
Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 


  Association between expresson and subtype.
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Cancer
Full Name
# Patients
P Value (Kruskal-Wallis)
Association
Source
BLCABladder urothelial carcinoma1280.762NS24476821
BRCABreast invasive carcinoma5216.85e-07Significant23000897
COADColon adenocarcinoma1490.0807NS22810696
GBMGlioblastoma multiforme1570.00122Significant26824661
HNSCHead and Neck squamous cell carcinoma2791.35e-05Significant25631445
KIRPKidney renal papillary cell carcinoma1613.41e-05Significant26536169
LGGBrain Lower Grade Glioma5136.51e-20Significant26824661
LUADLung adenocarcinoma2300.664NS25079552
LUSCLung squamous cell carcinoma1780.0272Significant22960745
OVOvarian serous cystadenocarcinoma2870.000212Significant21720365
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> Overall survival
 

  Overall survival analysis based on expression.
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Cancer
Full Name
# Patients
Hazard Ratio
P Value (Log Rank Test)
Association
BLCABladder urothelial carcinoma405 0.5860.0208Longer
BRCABreast invasive carcinoma1079 1.0460.847NS
CESCCervical and endocervical cancers291 0.6040.132NS
COADColon adenocarcinoma439 1.4030.26NS
ESCAEsophageal carcinoma184 1.2340.545NS
GBMGlioblastoma multiforme158 0.7090.177NS
HNSCHead and Neck squamous cell carcinoma518 0.6690.042Longer
KIRCKidney renal clear cell carcinoma531 1.0170.94NS
KIRPKidney renal papillary cell carcinoma287 0.3370.00982Longer
LAMLAcute Myeloid Leukemia149 0.7060.24NS
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> Stage
 

  Association between expresson and stage.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
BLCABladder urothelial carcinoma406 -0.0740.139NS
BRCABreast invasive carcinoma1071 0.0280.352NS
CESCCervical and endocervical cancers167 0.1520.0501NS
COADColon adenocarcinoma445 -0.0120.8NS
ESCAEsophageal carcinoma162 0.0840.29NS
HNSCHead and Neck squamous cell carcinoma448 0.0680.149NS
KIRCKidney renal clear cell carcinoma531 0.0330.447NS
KIRPKidney renal papillary cell carcinoma260 -0.180.00363Lower
LIHCLiver hepatocellular carcinoma347 -0.0760.158NS
LUADLung adenocarcinoma507 -0.0640.148NS
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> Grade
 

  Association between expresson and grade.
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Cancer
Full Name
# Patients
R Value (Spearman)
P Value (Spearman)
Association
CESCCervical and endocervical cancers272 -0.0250.679NS
HNSCHead and Neck squamous cell carcinoma498 0.1550.000507Higher
KIRCKidney renal clear cell carcinoma525 -0.070.111NS
LGGBrain Lower Grade Glioma514 -0.1220.00579Lower
LIHCLiver hepatocellular carcinoma366 -0.0580.27NS
OVOvarian serous cystadenocarcinoma296 0.0010.988NS
PAADPancreatic adenocarcinoma176 -0.0620.411NS
STADStomach adenocarcinoma406 0.1810.000249Higher
UCECUterine Corpus Endometrial Carcinoma534 0.1370.00149Higher
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Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for ING4.
Summary
SymbolING4
Nameinhibitor of growth family member 4
Aliases p29ING4; my036; brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protei ......
Location12p13.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
> Interactions from Text Mining
 
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PMID
Cancer
Hierarchy
Gene
Relation to CR
Evidence
27527891Prostate CarcinomadownstreamMiz1positive regulationING4 directly binds the Miz1 promoter and is required to induce Miz1 mRNA and protein expression during luminal cell differentiation.
27466989Cervical CarcinomapartnerHPV E6/E7positive correlationEctopic expression of ING4 reduced the proliferation of SiHa cells, accompanied by decreased HPV E6/E7 transcription.
26936485Colorectal CarcinomadownstreamP21; CDH1; CCNE1; IL-6; IL-8; VEGF; SNAI1; CDH2; VIMpositive regulation; positive regulation; negative regulation; negative regulation; negative regulation; negative regulation; negative regulation; negative regulation; negative regulationMechanistically, ING4 markedly upregulated P21 and E-cadherin but downregulated cyclin E, interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), Snail1, N-cadherin and vimentin in the LoVo CRC cells.
26813279AstrocytomapartnerHIF-1Anegative correlationThe mRNA expression showed a negative correlation between ING4 and HIF-1 alpha with the increase of the tumor malignant degree.
25792601Breast CarcinomapartnerJFKnegative correlationSignificantly, the expression of JFK is markedly up-regulated in breast cancer, and the level of JFK is negatively correlated with that of ING4 and positively correlated with an aggressive clinical behavior of breast carcinomas.
24762396Prostate CarcinomaupstreamPtenpositive regulationPten loss prevents differentiation by blocking ING4 expression, which is rescued by ING4 re-expression.
24057236Gastric Carcinomadownstreamp65; p-IκBα; MMP-9; uPA; IκBα negative regulation; negative regulation; negative regulation; negative regulation; positive regulationMost notably, increased ING4 level evidently evoked the down-regulation of p65, p-IκBα, MMP-9 and uPA proteins and the up-regulation of IκBα protein.
23056468Breast Carcinomapartnerp-p65negative correlationIn the same tumor set, we found that low ING4 expression correlated with high levels of nuclear phosphorylated p65/RelA (p-p65), an activated form of NF-κB (p=0.018).
23055189Colorectal CarcinomapartnerMVDnegative correlationImportantly, ING4 mRNA and protein levels were negatively correlated with MVD in CRC patients (p < 0.001).
22767438Hepatocellular CarcinomaupstreammiR-650negative regulationThese data suggested that miR-650 is correlated with the pathogenesis of HCC and is involved in the HCC tumorigenesis process by inhibiting the expression of ING4.
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