CR2Cancer

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF04795 PAPA-1-like conserved region
PF04438 HIT zinc finger

Function

Induces growth and cell cycle arrests at the G1 phase of the cell cycle. ; FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Classification

Class	Modification	Substrate	Product	PubMed
Chromatin remodelling cofactor	#	#	#	21303910

> Gene Ontology [ TOP ]
Biological Process	GO:0006310 DNA recombination GO:0006338 chromatin remodeling
Molecular Function	-
Cellular Component	GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0031011 Ino80 complex GO:0033202 DNA helicase complex GO:0044454 nuclear chromosome part GO:0070603 SWI/SNF superfamily-type complex GO:0097346 INO80-type complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5696394: DNA Damage Recognition in GG-NER R-HSA-73894: DNA Repair R-HSA-5688426: Deubiquitination R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-392499: Metabolism of proteins R-HSA-5696398: Nucleotide Excision Repair R-HSA-597592: Post-translational protein modification R-HSA-5689603: UCH proteinases

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM245033	c.910C>A	p.P304T	Substitution - Missense	Prostate
COSM3972359	c.858G>A	p.R286R	Substitution - coding silent	Central_nervous_system
COSM28349	c.1029G>T	p.T343T	Substitution - coding silent	Pancreas
COSM1023002	c.25G>A	p.A9T	Substitution - Missense	Endometrium
COSM5562125	c.874C>A	p.P292T	Substitution - Missense	Prostate
COSM2999520	c.876G>T	p.P292P	Substitution - coding silent	Upper_aerodigestive_tract
COSM5775247	c.196G>C	p.V66L	Substitution - Missense	Breast
COSM3364833	c.873C>G	p.G291G	Substitution - coding silent	Kidney
COSM4612140	c.11_12insA	p.E5fs*1	Insertion - Frameshift	Large_intestine
COSM5701148	c.722_723insG	p.A244fs*75	Insertion - Frameshift	Soft_tissue
COSM5032427	c.681G>C	p.E227D	Substitution - Missense	Oesophagus
COSM1210685	c.72G>T	p.K24N	Substitution - Missense	Large_intestine
COSM1023004	c.457G>T	p.D153Y	Substitution - Missense	Endometrium
COSM128238	c.360A>G	p.P120P	Substitution - coding silent	Upper_aerodigestive_tract
COSM5562115	c.867C>T	p.P289P	Substitution - coding silent	Prostate
COSM4912398	c.403G>A	p.E135K	Substitution - Missense	Liver
COSM4954983	c.843G>T	p.T281T	Substitution - coding silent	Liver
COSM5157581	c.916C>T	p.R306C	Substitution - Missense	Breast
COSM3840046	c.478G>A	p.E160K	Substitution - Missense	Breast
COSM1023005	c.481C>T	p.R161W	Substitution - Missense	Endometrium
COSM4954983	c.843G>T	p.T281T	Substitution - coding silent	Liver
COSM291739	c.63A>T	p.G21G	Substitution - coding silent	Large_intestine
COSM4095756	c.44C>T	p.A15V	Substitution - Missense	Stomach
COSM4583643	c.72_73insA	p.H27fs*67	Insertion - Frameshift	Bone
COSM1683240	c.996_997insGC	p.P333fs*>12	Insertion - Frameshift	Ovary
COSM4414787	c.949T>A	p.C317S	Substitution - Missense	Kidney
COSM1690722	c.337G>A	p.D113N	Substitution - Missense	Skin
COSM443225	c.876G>C	p.P292P	Substitution - coding silent	Breast
COSM3963079	c.1005T>G	p.G335G	Substitution - coding silent	Lung
COSM4765301	c.73_74insA	p.H27fs*67	Insertion - Frameshift	Stomach
COSM3407985	c.932G>A	p.R311H	Substitution - Missense	Prostate
COSM4095758	c.354C>A	p.P118P	Substitution - coding silent	Stomach
COSM5782595	c.620C>T	p.A207V	Substitution - Missense	Breast
COSM3583362	c.992G>A	p.G331E	Substitution - Missense	Skin
COSM240232	c.213-1G>C	p.?	Unknown	Prostate
COSM5646026	c.212+1G>C	p.?	Unknown	Oesophagus
COSM4095761	c.998C>A	p.P333H	Substitution - Missense	Stomach
COSM4886177	c.320G>A	p.R107H	Substitution - Missense	Upper_aerodigestive_tract
COSM5509634	c.990delG	p.E334fs*>10	Deletion - Frameshift	Biliary_tract
COSM443225	c.876G>C	p.P292P	Substitution - coding silent	Soft_tissue
COSM240233	c.439delG	p.E147fs*40	Deletion - Frameshift	Prostate
COSM5511733	c.569G>A	p.C190Y	Substitution - Missense	Biliary_tract
COSM3407985	c.932G>A	p.R311H	Substitution - Missense	Central_nervous_system
COSM1565468	c.589G>T	p.E197*	Substitution - Nonsense	Large_intestine
COSM384781	c.92A>T	p.K31M	Substitution - Missense	Lung
COSM5786220	c.996G>T	p.G332G	Substitution - coding silent	Breast
COSM1179092	c.469G>C	p.E157Q	Substitution - Missense	Prostate
COSM5511731	c.153delT	p.A52fs*26	Deletion - Frameshift	Biliary_tract
COSM722497	c.896C>G	p.P299R	Substitution - Missense	Lung
COSM4776257	c.56G>A	p.G19D	Substitution - Missense	Soft_tissue
COSM5695353	c.676A>G	p.I226V	Substitution - Missense	Soft_tissue
COSM5978391	c.775A>G	p.M259V	Substitution - Missense	Upper_aerodigestive_tract
COSM5691401	c.118C>A	p.Q40K	Substitution - Missense	Soft_tissue
COSM4838596	c.562G>A	p.E188K	Substitution - Missense	Cervix
COSM4548937	c.421G>A	p.D141N	Substitution - Missense	Skin
COSM4692527	c.932G>T	p.R311L	Substitution - Missense	Large_intestine
COSM4406768	c.408A>T	p.E136D	Substitution - Missense	Pancreas
COSM722498	c.251C>T	p.S84L	Substitution - Missense	Lung
COSM5509634	c.990delG	p.E334fs*>10	Deletion - Frameshift	Biliary_tract
COSM1023003	c.411G>A	p.Q137Q	Substitution - coding silent	Endometrium
COSM196099	c.465G>T	p.K155N	Substitution - Missense	Stomach

> Text Mining based Variations [ TOP ]
There is no record for INO80B.

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9C086	99	S	Phosphoserine	-	No	None detected
Q9C086	127	S	Phosphoserine	-	No	None detected
Q9C086	130	S	Phosphoserine	-	No	None detected
Q9C086	132	S	Phosphoserine	-	No	None detected

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	3.941	4.638	0.948	2.59e-07	Over
BRCA	Breast invasive carcinoma	112	1100	2.851	3.57	0.677	1.48e-11	Over
CESC	Cervical and endocervical cancers	3	306	3.781	4.159	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	3.492	4.154	0.701	7.9e-09	Over
ESCA	Esophageal carcinoma	11	185	3.447	3.761	0.367	0.103	NS
GBM	Glioblastoma multiforme	5	166	4.517	3.993	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	3.715	4.123	0.371	0.00227	NS
KIRC	Kidney renal clear cell carcinoma	72	534	3.368	4.162	0.856	2.27e-16	Over
KIRP	Kidney renal papillary cell carcinoma	32	291	4.085	4.474	0.434	0.002	NS
LAML	Acute Myeloid Leukemia	0	173	NA	3.549	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.231	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.695	4.053	0.301	0.00883	NS
LUAD	Lung adenocarcinoma	59	517	3.652	4.065	0.401	5.85e-05	NS
LUSC	Lung squamous cell carcinoma	51	501	3.238	4.19	0.994	2.72e-19	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.999	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	3.83	4.259	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.906	4.435	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	3.531	4.413	0.819	1.25e-12	Over
READ	Rectum adenocarcinoma	10	167	3.015	4.08	1.11	4.96e-06	Over
SARC	Sarcoma	2	263	3.363	3.595	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	3.643	4.3	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.003	3.742	-0.08	0.583	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	3.42	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.013	4.407	0.371	0.000276	NS
THYM	Thymoma	2	120	4.688	4.872	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.334	4.739	0.422	0.00574	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	16.2
Adrenal gland	19.3
Appendix	22.6
Bone marrow	11.6
Breast	19.4
Cerebral cortex	34.5
Cervix, uterine	21.5
Colon	12.2
Duodenum	18.7
Endometrium	34.3
Epididymis	19.6
Esophagus	14.6
Fallopian tube	31.2
Gallbladder	22.2
Heart muscle	7.4
Kidney	15.6
Liver	7.9
Lung	20
Lymph node	20.3
Ovary	34.8
Pancreas	4.2
Parathyroid gland	42
Placenta	14.7
Prostate	26.1
Rectum	13.4
Salivary gland	10.9
Seminal vesicle	20.7
Skeletal muscle	5
Skin	35.9
Small intestine	15.3
Smooth muscle	21.3
Spleen	21.3
Stomach	15.9
Testis	30
Thyroid gland	27.9
Tonsil	18.4
Urinary bladder	16.6

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.343	1.38e-12	7.9	59.4	32.7	Neutral
BRCA	Breast invasive carcinoma	1075	0.173	1.12e-08	15	68.7	16.3	Neutral
CESC	Cervical and endocervical cancers	292	0.348	9.66e-10	5.5	71.6	22.9	Neutral
COAD	Colon adenocarcinoma	449	0.084	0.0749	1.6	80.2	18.3	Neutral
ESCA	Esophageal carcinoma	183	0.29	6.64e-05	4.4	55.7	39.9	Gain
GBM	Glioblastoma multiforme	147	0.239	0.00362	5.4	87.1	7.5	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.301	2.93e-12	4.7	73.9	21.4	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.28	6.48e-11	2.7	83	14.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.235	5.46e-05	2.4	82.6	14.9	Neutral
LAML	Acute Myeloid Leukemia	166	0.06	0.441	0	99.4	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.137	0.00189	4.3	93.2	2.5	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.253	1.04e-06	10.2	78.6	11.3	Neutral
LUAD	Lung adenocarcinoma	512	0.282	8.48e-11	5.3	65.2	29.5	Neutral
LUSC	Lung squamous cell carcinoma	498	0.378	2.19e-18	2	49.2	48.8	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.367	5.37e-11	10.7	52.3	37	Gain
PAAD	Pancreatic adenocarcinoma	177	0.094	0.215	6.2	85.9	7.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.258	0.000911	6.8	90.1	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	0.185	3.81e-05	6.9	90.2	2.9	Neutral
READ	Rectum adenocarcinoma	164	0.14	0.074	7.3	70.1	22.6	Neutral
SARC	Sarcoma	255	0.464	5.34e-15	31.8	55.3	12.9	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.213	3.81e-05	13.6	68.7	17.7	Neutral
STAD	Stomach adenocarcinoma	413	0.259	9.28e-08	4.1	75.1	20.8	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.359	6.5e-06	6.7	60.7	32.7	Neutral
THCA	Thyroid carcinoma	497	0.121	0.00703	1.8	97.8	0.4	Neutral
THYM	Thymoma	119	0.162	0.0792	0.8	98.3	0.8	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.292	5.52e-12	2	78	19.9	Neutral

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.279	5.36e-09	17	408	-0.031	0.000132	NS/NA
BRCA	Breast invasive carcinoma	-0.238	1.48e-12	83	785	-0.011	3e-07	NS/NA
CESC	Cervical and endocervical cancers	-0.136	0.0165	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.147	0.00872	19	297	-0.014	0.221	NS/NA
ESCA	Esophageal carcinoma	-0.199	0.0055	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.105	0.403	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.173	5.27e-05	20	522	-0.007	0.00898	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.321	1.43e-09	24	319	-0.006	0.0363	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.081	0.163	23	275	-0.005	0.0219	NS/NA
LAML	Acute Myeloid Leukemia	-0.098	0.201	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.073	0.0951	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.144	0.00345	41	373	-0.117	7.95e-07	NS/NA
LUAD	Lung adenocarcinoma	-0.162	0.000373	21	456	-0.023	9.03e-06	NS/NA
LUSC	Lung squamous cell carcinoma	-0.193	0.000163	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.35	0.359	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.158	0.0325	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.172	0.0189	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.283	3.38e-11	35	498	-0.095	5.64e-07	NS/NA
READ	Rectum adenocarcinoma	-0.31	0.00168	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.281	4.14e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.196	1.93e-05	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.069	0.185	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.333	2.4e-05	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.082	0.0522	50	509	-0.157	0.00202	NS/NA
THYM	Thymoma	-0.171	0.0597	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.177	0.000126	34	431	-0.003	0.032	NS/NA

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.00614	Significant	24476821
BRCA	Breast invasive carcinoma	521	0.174	NS	23000897
COAD	Colon adenocarcinoma	149	0.125	NS	22810696
GBM	Glioblastoma multiforme	157	0.011	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	2.49e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.349	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.16e-05	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00353	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0771	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	6.68e-07	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0903	NS	26544944
READ	Rectum adenocarcinoma	67	0.0436	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.63	NS	26091043
STAD	Stomach adenocarcinoma	277	0.0184	Significant	25079317
THCA	Thyroid carcinoma	391	0.252	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.118	NS	23636398

> Overall survival

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Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.733	0.142	NS
BRCA	Breast invasive carcinoma	1079	0.643	0.0635	NS
CESC	Cervical and endocervical cancers	291	1.292	0.459	NS
COAD	Colon adenocarcinoma	439	1.062	0.836	NS
ESCA	Esophageal carcinoma	184	0.848	0.594	NS
GBM	Glioblastoma multiforme	158	0.646	0.11	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.017	0.932	NS
KIRC	Kidney renal clear cell carcinoma	531	1.407	0.105	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.344	0.524	NS
LAML	Acute Myeloid Leukemia	149	0.953	0.862	NS
LGG	Brain Lower Grade Glioma	511	0.953	0.851	NS
LIHC	Liver hepatocellular carcinoma	365	0.814	0.387	NS
LUAD	Lung adenocarcinoma	502	0.842	0.414	NS
LUSC	Lung squamous cell carcinoma	494	0.719	0.128	NS
OV	Ovarian serous cystadenocarcinoma	303	1.051	0.819	NS
PAAD	Pancreatic adenocarcinoma	177	0.891	0.68	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0.344	0.334	NS
PRAD	Prostate adenocarcinoma	497	2.089	0.539	NS
READ	Rectum adenocarcinoma	159	1.635	0.36	NS
SARC	Sarcoma	259	0.56	0.0532	NS
SKCM	Skin Cutaneous Melanoma	459	0.901	0.571	NS
STAD	Stomach adenocarcinoma	388	0.736	0.166	NS
TGCT	Testicular Germ Cell Tumors	134	0.871	0.922	NS
THCA	Thyroid carcinoma	500	0.739	0.691	NS
THYM	Thymoma	119	1.322	0.82	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.883	0.702	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.098	0.0485	Lower
BRCA	Breast invasive carcinoma	1071	0.021	0.501	NS
CESC	Cervical and endocervical cancers	167	-0.008	0.918	NS
COAD	Colon adenocarcinoma	445	0.031	0.517	NS
ESCA	Esophageal carcinoma	162	-0.07	0.375	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.039	0.405	NS
KIRC	Kidney renal clear cell carcinoma	531	0.099	0.0224	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.064	0.303	NS
LIHC	Liver hepatocellular carcinoma	347	-0.07	0.194	NS
LUAD	Lung adenocarcinoma	507	0.063	0.157	NS
LUSC	Lung squamous cell carcinoma	497	0.104	0.0201	Higher
OV	Ovarian serous cystadenocarcinoma	302	0.055	0.343	NS
PAAD	Pancreatic adenocarcinoma	176	0.004	0.956	NS
READ	Rectum adenocarcinoma	156	0.049	0.54	NS
SKCM	Skin Cutaneous Melanoma	410	-0.005	0.922	NS
STAD	Stomach adenocarcinoma	392	-0.113	0.0252	Lower
TGCT	Testicular Germ Cell Tumors	81	0.2	0.0741	NS
THCA	Thyroid carcinoma	499	0.078	0.0806	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.006	0.889	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.062	0.312	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.109	0.0146	Lower
KIRC	Kidney renal clear cell carcinoma	525	0.038	0.385	NS
LGG	Brain Lower Grade Glioma	514	0.002	0.96	NS
LIHC	Liver hepatocellular carcinoma	366	-0.029	0.583	NS
OV	Ovarian serous cystadenocarcinoma	296	0.1	0.0874	NS
PAAD	Pancreatic adenocarcinoma	176	0.074	0.329	NS
STAD	Stomach adenocarcinoma	406	-0.095	0.0564	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.057	0.191	NS

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for INO80B.

Summary
Symbol	INO80B
Name	INO80 complex subunit B
Aliases	HMGIYL4; PAPA-1; hIes2; PAP-1BP; IES2; PAP-1 binding protein; IES2 homolog (S. cerevisiae); HMGA1L4; ZNHIT4; ......
Location	2p13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for INO80B.