CR2Cancer

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF00583 Acetyltransferase (GNAT) family
PF00439 Bromodomain
PF06466 PCAF (P300/CBP-associated factor) N-terminal domain

Function

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone acetylation	#	#	8945521

> Gene Ontology [ TOP ]
Biological Process	GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0001933 negative regulation of protein phosphorylation GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006094 gluconeogenesis GO:0006109 regulation of carbohydrate metabolic process GO:0006111 regulation of gluconeogenesis GO:0006338 chromatin remodeling GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006469 negative regulation of protein kinase activity GO:0006471 protein ADP-ribosylation GO:0006473 protein acetylation GO:0006474 N-terminal protein amino acid acetylation GO:0006475 internal protein amino acid acetylation GO:0006486 protein glycosylation GO:0007050 cell cycle arrest GO:0007219 Notch signaling pathway GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0010559 regulation of glycoprotein biosynthetic process GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010676 positive regulation of cellular carbohydrate metabolic process GO:0010835 regulation of protein ADP-ribosylation GO:0010906 regulation of glucose metabolic process GO:0010907 positive regulation of glucose metabolic process GO:0016051 carbohydrate biosynthetic process GO:0016570 histone modification GO:0016573 histone acetylation GO:0018076 N-terminal peptidyl-lysine acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019318 hexose metabolic process GO:0019319 hexose biosynthetic process GO:0031365 N-terminal protein amino acid modification GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033673 negative regulation of kinase activity GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter GO:0040029 regulation of gene expression, epigenetic GO:0042326 negative regulation of phosphorylation GO:0043255 regulation of carbohydrate biosynthetic process GO:0043413 macromolecule glycosylation GO:0043434 response to peptide hormone GO:0043543 protein acylation GO:0043966 histone H3 acetylation GO:0043970 histone H3-K9 acetylation GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0045722 positive regulation of gluconeogenesis GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045786 negative regulation of cell cycle GO:0045815 positive regulation of gene expression, epigenetic GO:0045913 positive regulation of carbohydrate metabolic process GO:0046364 monosaccharide biosynthetic process GO:0048511 rhythmic process GO:0051348 negative regulation of transferase activity GO:0060049 regulation of protein glycosylation GO:0061647 histone H3-K9 modification GO:0070085 glycosylation GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1903018 regulation of glycoprotein metabolic process GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904030 negative regulation of cyclin-dependent protein kinase activity
Molecular Function	GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor GO:0004857 enzyme inhibitor activity GO:0004860 protein kinase inhibitor activity GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0019207 kinase regulator activity GO:0019210 kinase inhibitor activity GO:0019887 protein kinase regulator activity GO:0030291 protein serine/threonine kinase inhibitor activity GO:0034212 peptide N-acetyltransferase activity GO:0042826 histone deacetylase binding GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0000125 PCAF complex GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex GO:0015629 actin cytoskeleton GO:0030016 myofibril GO:0030017 sarcomere GO:0031248 protein acetyltransferase complex GO:0031672 A band GO:0031674 I band GO:0042641 actomyosin GO:0043292 contractile fiber GO:0044449 contractile fiber part GO:0070461 SAGA-type complex GO:0098687 chromosomal region GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04330 Notch signaling pathway hsa04919 Thyroid hormone signaling pathway
Reactome	R-HSA-5250924: B-WICH complex positively regulates rRNA expression R-HSA-5576891: Cardiac conduction R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-5688426: Deubiquitination R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214847: HATs acetylate histones R-HSA-392499: Metabolism of proteins R-HSA-5689901: Metalloprotease DUBs R-HSA-397014: Muscle contraction R-HSA-157052: NICD traffics to nucleus R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-350054: Notch-HLH transcription pathway R-HSA-5578768: Physiological factors R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-597592: Post-translational protein modification R-HSA-1912422: Pre-NOTCH Expression and Processing R-HSA-1912408: Pre-NOTCH Transcription and Translation R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73864: RNA Polymerase I Transcription R-HSA-73762: RNA Polymerase I Transcription Initiation R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04330 Notch signaling pathway
hsa04919 Thyroid hormone signaling pathway

Reactome

R-HSA-5250924: B-WICH complex positively regulates rRNA expression
R-HSA-5576891: Cardiac conduction
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-5688426: Deubiquitination
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214847: HATs acetylate histones
R-HSA-392499: Metabolism of proteins
R-HSA-5689901: Metalloprotease DUBs
R-HSA-397014: Muscle contraction
R-HSA-157052: NICD traffics to nucleus
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-350054: Notch-HLH transcription pathway
R-HSA-5578768: Physiological factors
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-597592: Post-translational protein modification
R-HSA-1912422: Pre-NOTCH Expression and Processing
R-HSA-1912408: Pre-NOTCH Transcription and Translation
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-2032785: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM3915680	c.1199C>T	p.S400L	Substitution - Missense	Skin
COSM5994770	c.1475G>C	p.G492A	Substitution - Missense	Prostate
COSM1670005	c.212G>T	p.G71V	Substitution - Missense	Central_nervous_system
COSM3592022	c.557T>A	p.V186D	Substitution - Missense	Skin
COSM3823577	c.2220+2T>G	p.?	Unknown	Breast
COSM1422138	c.1425G>A	p.L475L	Substitution - coding silent	Large_intestine
COSM4152403	c.1276+8C>T	p.?	Unknown	Kidney
COSM4116593	c.2052T>G	p.V684V	Substitution - coding silent	Stomach
COSM4975384	c.1000C>T	p.L334L	Substitution - coding silent	Oesophagus
COSM5344445	c.838G>C	p.E280Q	Substitution - Missense	Large_intestine
COSM4185564	c.1676G>A	p.C559Y	Substitution - Missense	Kidney
COSM479984	c.991A>G	p.K331E	Substitution - Missense	Kidney
COSM4492859	c.404C>T	p.S135F	Substitution - Missense	Skin
COSM1043292	c.1469G>A	p.R490H	Substitution - Missense	Endometrium
COSM3823574	c.1083C>G	p.N361K	Substitution - Missense	Breast
COSM1043295	c.2381G>A	p.R794Q	Substitution - Missense	Endometrium
COSM4913375	c.1958G>T	p.R653L	Substitution - Missense	Liver
COSM5232416	c.2391_2392insA	p.N798fs*9	Insertion - Frameshift	Breast
COSM3945370	c.1670G>T	p.G557V	Substitution - Missense	Lung
COSM1537710	c.568C>T	p.L190L	Substitution - coding silent	Skin
COSM1043290	c.938G>A	p.R313H	Substitution - Missense	Endometrium
COSM1043288	c.718G>T	p.E240*	Substitution - Nonsense	Endometrium
COSM4437595	c.658A>G	p.S220G	Substitution - Missense	Oesophagus
COSM317495	c.1623-2A>G	p.?	Unknown	Soft_tissue
COSM4116587	c.625T>A	p.S209T	Substitution - Missense	Stomach
COSM171921	c.2044C>T	p.R682*	Substitution - Nonsense	Large_intestine
COSM1422139	c.1525A>G	p.K509E	Substitution - Missense	Large_intestine
COSM5814550	c.2382A>G	p.R794R	Substitution - coding silent	Liver
COSM3592023	c.668A>T	p.Q223L	Substitution - Missense	Skin
COSM1043292	c.1469G>A	p.R490H	Substitution - Missense	Endometrium
COSM2948444	c.1016G>A	p.R339Q	Substitution - Missense	Large_intestine
COSM1239183	c.1492G>A	p.V498M	Substitution - Missense	Oesophagus
COSM5355132	c.664G>T	p.E222*	Substitution - Nonsense	Large_intestine
COSM3592031	c.2416G>T	p.E806*	Substitution - Nonsense	Skin
COSM730422	c.544G>T	p.D182Y	Substitution - Missense	Lung
COSM321095	c.871G>T	p.V291L	Substitution - Missense	Lung
COSM1043293	c.1622+2T>C	p.?	Unknown	Endometrium
COSM4909775	c.360C>G	p.P120P	Substitution - coding silent	Liver
COSM730419	c.2205C>T	p.I735I	Substitution - coding silent	Lung
COSM2948456	c.1583G>A	p.R528Q	Substitution - Missense	Large_intestine
COSM1043292	c.1469G>A	p.R490H	Substitution - Missense	Endometrium
COSM479983	c.313T>C	p.S105P	Substitution - Missense	Kidney
COSM4568915	c.1403T>A	p.L468H	Substitution - Missense	Skin
COSM5653963	c.579C>T	p.L193L	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM1291682	c.1260A>G	p.G420G	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM232575	c.1774C>T	p.H592Y	Substitution - Missense	Skin
COSM1255199	c.1730C>T	p.T577I	Substitution - Missense	Oesophagus
COSM4618324	c.830G>T	p.G277V	Substitution - Missense	Large_intestine
COSM4790584	c.2380C>T	p.R794*	Substitution - Nonsense	Liver
COSM4694044	c.306C>T	p.A102A	Substitution - coding silent	Large_intestine
COSM5781388	c.1222G>A	p.A408T	Substitution - Missense	Breast
COSM1043294	c.2027G>T	p.R676I	Substitution - Missense	Endometrium
COSM5799903	c.2371G>C	p.D791H	Substitution - Missense	Breast
COSM4005520	c.349T>C	p.S117P	Substitution - Missense	Urinary_tract
COSM5398996	c.1264G>T	p.E422*	Substitution - Nonsense	Skin
COSM3592026	c.1038C>T	p.F346F	Substitution - coding silent	Skin
COSM5591437	c.333_334insA	p.N113fs*3	Insertion - Frameshift	Skin
COSM4469648	c.1611C>T	p.L537L	Substitution - coding silent	Skin
COSM3993001	c.2055C>T	p.Y685Y	Substitution - coding silent	Kidney
COSM275627	c.1594G>T	p.E532*	Substitution - Nonsense	Endometrium
COSM308403	c.2137C>A	p.P713T	Substitution - Missense	Kidney
COSM1753138	c.1844G>T	p.G615V	Substitution - Missense	Urinary_tract
COSM321095	c.871G>T	p.V291L	Substitution - Missense	Oesophagus
COSM4116586	c.560A>G	p.Y187C	Substitution - Missense	Stomach
COSM4879983	c.805C>T	p.R269*	Substitution - Nonsense	Prostate
COSM4116588	c.962G>A	p.R321Q	Substitution - Missense	Stomach
COSM3729231	c.2236T>C	p.W746R	Substitution - Missense	Stomach
COSM40442	c.1387G>A	p.D463N	Substitution - Missense	Central_nervous_system
COSM4939641	c.1150+2T>G	p.?	Unknown	Liver
COSM4404007	c.1088C>T	p.P363L	Substitution - Missense	Skin
COSM4790584	c.2380C>T	p.R794*	Substitution - Nonsense	Liver
COSM171921	c.2044C>T	p.R682*	Substitution - Nonsense	Large_intestine
COSM1753137	c.309G>A	p.E103E	Substitution - coding silent	Urinary_tract
COSM1485068	c.1607G>A	p.R536Q	Substitution - Missense	Breast
COSM1719201	c.1915G>A	p.D639N	Substitution - Missense	Skin
COSM4443464	c.1339G>T	p.G447W	Substitution - Missense	Large_intestine
COSM3767384	c.429A>C	p.L143L	Substitution - coding silent	Liver
COSM5516257	c.502G>A	p.V168M	Substitution - Missense	Biliary_tract
COSM1741304	c.1198T>A	p.S400T	Substitution - Missense	Urinary_tract
COSM166619	c.1368G>A	p.E456E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM3592020	c.443C>T	p.S148F	Substitution - Missense	Skin
COSM3592028	c.1680C>T	p.F560F	Substitution - coding silent	Skin
COSM3823575	c.1658G>A	p.R553H	Substitution - Missense	Breast
COSM730421	c.760C>T	p.R254C	Substitution - Missense	Lung
COSM5555634	c.1499G>A	p.G500D	Substitution - Missense	Prostate
COSM1719201	c.1915G>A	p.D639N	Substitution - Missense	Skin
COSM2948441	c.898C>T	p.R300W	Substitution - Missense	Liver
COSM5025912	c.677A>T	p.N226I	Substitution - Missense	Breast
COSM5768627	c.1609C>T	p.L537F	Substitution - Missense	Breast
COSM1422140	c.1560C>T	p.N520N	Substitution - coding silent	Large_intestine
COSM1422135	c.392G>A	p.S131N	Substitution - Missense	Large_intestine
COSM5439573	c.941C>G	p.S314W	Substitution - Missense	Oesophagus
COSM5995036	c.1914G>T	p.K638N	Substitution - Missense	Prostate
COSM4978853	c.2327G>A	p.R776H	Substitution - Missense	Oesophagus
COSM87783	c.409C>T	p.R137W	Substitution - Missense	Large_intestine
COSM5962296	c.2498G>C	p.*833S	Nonstop extension	Breast
COSM4152401	c.1159C>A	p.P387T	Substitution - Missense	Kidney
COSM4152402	c.1276+7T>A	p.?	Unknown	Kidney
COSM1043287	c.636G>T	p.K212N	Substitution - Missense	Endometrium
COSM166619	c.1368G>A	p.E456E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5647657	c.461C>G	p.S154*	Substitution - Nonsense	Oesophagus
COSM5653242	c.1768A>T	p.M590L	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1043289	c.871G>A	p.V291M	Substitution - Missense	Endometrium
COSM4917580	c.866G>A	p.C289Y	Substitution - Missense	Liver
COSM2948452	c.1366G>A	p.E456K	Substitution - Missense	Biliary_tract
COSM1043287	c.636G>T	p.K212N	Substitution - Missense	Large_intestine
COSM2948444	c.1016G>A	p.R339Q	Substitution - Missense	Large_intestine
COSM3427481	c.2035G>A	p.A679T	Substitution - Missense	Large_intestine
COSM4116589	c.1365C>T	p.N455N	Substitution - coding silent	Stomach
COSM282051	c.669+6A>C	p.?	Unknown	Large_intestine
COSM3592021	c.522T>A	p.C174*	Substitution - Nonsense	Skin
COSM1617434	c.2378A>T	p.Q793L	Substitution - Missense	Liver
COSM2948458	c.1843G>A	p.G615R	Substitution - Missense	Large_intestine
COSM1741305	c.1199C>G	p.S400*	Substitution - Nonsense	Urinary_tract
COSM4116590	c.1571A>G	p.H524R	Substitution - Missense	Stomach
COSM275628	c.1873G>T	p.E625*	Substitution - Nonsense	Large_intestine
COSM3392311	c.761G>A	p.R254H	Substitution - Missense	Pancreas
COSM420054	c.256C>G	p.P86A	Substitution - Missense	Urinary_tract
COSM4538051	c.2498G>A	p.833	Substitution - coding silent	Skin
COSM1043291	c.1331G>A	p.R444Q	Substitution - Missense	Endometrium
COSM3592027	c.1657C>G	p.R553G	Substitution - Missense	Skin
COSM446299	c.1155C>A	p.I385I	Substitution - coding silent	Breast
COSM1043291	c.1331G>A	p.R444Q	Substitution - Missense	Skin
COSM4116585	c.430+2T>C	p.?	Unknown	Stomach
COSM1617433	c.430+4A>C	p.?	Unknown	Liver
COSM5885483	c.2298C>T	p.F766F	Substitution - coding silent	Urinary_tract
COSM1753138	c.1844G>T	p.G615V	Substitution - Missense	Urinary_tract
COSM4418905	c.309G>T	p.E103D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM321096	c.1700G>C	p.G567A	Substitution - Missense	Lung
COSM1422140	c.1560C>T	p.N520N	Substitution - coding silent	Breast
COSM4116591	c.1601T>G	p.I534S	Substitution - Missense	Stomach
COSM3726408	c.1260A>C	p.G420G	Substitution - coding silent	Lung
COSM1753137	c.309G>A	p.E103E	Substitution - coding silent	Urinary_tract
COSM4439734	c.2331C>G	p.L777L	Substitution - coding silent	Oesophagus
COSM245126	c.1981G>A	p.V661I	Substitution - Missense	Prostate
COSM77927	c.457G>A	p.V153M	Substitution - Missense	Ovary
COSM134070	c.1853A>G	p.K618R	Substitution - Missense	Skin
COSM3823573	c.410G>A	p.R137Q	Substitution - Missense	Breast
COSM1242400	c.2011delA	p.K672fs*2	Deletion - Frameshift	Oesophagus
COSM5547437	c.1510delA	p.N504fs*9	Deletion - Frameshift	Prostate
COSM3592029	c.1831G>A	p.E611K	Substitution - Missense	Skin
COSM1043292	c.1469G>A	p.R490H	Substitution - Missense	Large_intestine
COSM317495	c.1623-2A>G	p.?	Unknown	Lung
COSM3427481	c.2035G>A	p.A679T	Substitution - Missense	Stomach
COSM3993000	c.1301C>G	p.S434C	Substitution - Missense	Kidney
COSM4116594	c.2351C>G	p.S784C	Substitution - Missense	Stomach
COSM77927	c.457G>A	p.V153M	Substitution - Missense	Ovary
COSM1753137	c.309G>A	p.E103E	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM379302	c.2368G>A	p.A790T	Substitution - Missense	Lung
COSM4416688	c.1157A>G	p.N386S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM4460430	c.1165C>T	p.P389S	Substitution - Missense	Skin
COSM3823576	c.1704C>T	p.F568F	Substitution - coding silent	Breast
COSM4402835	c.2172C>T	p.D724D	Substitution - coding silent	Skin
COSM2948439	c.811C>T	p.P271S	Substitution - Missense	Skin
COSM87783	c.409C>T	p.R137W	Substitution - Missense	Pancreas
COSM3592025	c.1026C>T	p.I342I	Substitution - coding silent	Skin
COSM1422142	c.1907A>T	p.Y636F	Substitution - Missense	Large_intestine
COSM730420	c.1757G>T	p.G586V	Substitution - Missense	Lung
COSM4612443	c.2297_2298insC	p.M768fs*8	Insertion - Frameshift	Large_intestine
COSM3592024	c.833A>T	p.Y278F	Substitution - Missense	Skin
COSM446300	c.1536G>T	p.L512L	Substitution - coding silent	Breast
COSM1617434	c.2378A>T	p.Q793L	Substitution - Missense	Liver
COSM4768972	c.1301C>T	p.S434F	Substitution - Missense	Biliary_tract
COSM4116592	c.1667G>A	p.G556D	Substitution - Missense	Stomach
COSM5808872	c.1489C>T	p.H497Y	Substitution - Missense	Liver
COSM4750867	c.821A>G	p.D274G	Substitution - Missense	Stomach
COSM4439733	c.2032C>A	p.Q678K	Substitution - Missense	Oesophagus
COSM4694045	c.2409delC	p.P805fs*25	Deletion - Frameshift	Large_intestine
COSM2948460	c.1964C>T	p.P655L	Substitution - Missense	Stomach
COSM479985	c.1029C>T	p.L343L	Substitution - coding silent	Kidney
COSM5581411	c.284G>A	p.G95E	Substitution - Missense	Skin
COSM182663	c.2045G>A	p.R682Q	Substitution - Missense	Endometrium
COSM182663	c.2045G>A	p.R682Q	Substitution - Missense	Skin
COSM4149821	c.2156+5G>A	p.?	Unknown	Ovary
COSM3696008	c.1274C>A	p.P425Q	Substitution - Missense	Large_intestine
COSM3427482	c.2087G>A	p.R696Q	Substitution - Missense	Large_intestine
COSM4437218	c.1783G>C	p.E595Q	Substitution - Missense	Oesophagus
COSM275627	c.1594G>T	p.E532*	Substitution - Nonsense	Large_intestine
COSM730423	c.275A>G	p.E92G	Substitution - Missense	Lung
COSM3592030	c.2095C>T	p.P699S	Substitution - Missense	Skin
COSM2948458	c.1843G>A	p.G615R	Substitution - Missense	Large_intestine
COSM275626	c.1483G>T	p.E495*	Substitution - Nonsense	Large_intestine

> Text Mining based Variations

[ TOP ]

PMID	Variation	Cancer	Evidence
26662507	Mutation; Copy Number change	Clear Cell Renal Cell Carcinoma	We have in this study studied the genetic alteration (mutation and copy number variance) of Notch gene set in the Cancer Genome Atlas (TCGA) Kidney Renal Clear Cell Carcinoma (KIRC) database. We found that Notch pathway was frequently altered in ccRCC. The Notch gene set was genetically altered in 182 (44%) of the 415 ccRCC patients. CNV was the predominant type of alteration in most genes. Alterations in KAT2B and MAML1 occurred in 13% and 19% of patients, respectively, both of which were functionally active in ccRCC.
22709982	Mutation	Hepatocellular Carcinoma	Sequencing methods were used to determine the genotype at the Ile997Val and Asn386Ser on EP300 and PCAF. It appears that variants of the transcriptional coactivator genes (EP300 and PCAF) may influence HCC risk in populations with low mutations or chromosomal instability rates.

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM) [ TOP ]
There is no PTM data

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.514	4.436	-1.007	9.19e-05	Under
BRCA	Breast invasive carcinoma	112	1100	5.231	3.944	-1.429	1.2e-59	Under
CESC	Cervical and endocervical cancers	3	306	5.218	4.041	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.143	3.321	-1.957	7.64e-31	Under
ESCA	Esophageal carcinoma	11	185	6.422	4.474	-1.916	6.34e-08	Under
GBM	Glioblastoma multiforme	5	166	6.271	6.46	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.814	3.743	-2.05	1.24e-34	Under
KIRC	Kidney renal clear cell carcinoma	72	534	5.938	5.284	-0.708	1.78e-23	Under
KIRP	Kidney renal papillary cell carcinoma	32	291	5.673	4.452	-1.246	2.45e-17	Under
LAML	Acute Myeloid Leukemia	0	173	NA	5.96	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.16	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	5.601	4.699	-0.933	1.07e-09	Under
LUAD	Lung adenocarcinoma	59	517	5.726	4.395	-1.332	7.42e-35	Under
LUSC	Lung squamous cell carcinoma	51	501	5.515	3.818	-1.826	9.54e-54	Under
OV	Ovarian serous cystadenocarcinoma	0	307	NA	4.332	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	4.889	4.468	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.596	4.433	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.574	5.162	-0.391	3.58e-05	NS
READ	Rectum adenocarcinoma	10	167	5.356	3.027	-2.306	1.81e-10	Under
SARC	Sarcoma	2	263	5.092	4.741	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.234	5.839	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.922	4.664	-1.61	1.13e-22	Under
TGCT	Testicular Germ Cell Tumors	0	156	NA	3.871	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.557	5.229	-0.301	0.000566	NS
THYM	Thymoma	2	120	6.219	5.366	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.86	3.554	-1.477	1.22e-15	Under

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	6.6
Autonomic ganglia	CHP212	5.7
Autonomic ganglia	IMR32	5.4
Autonomic ganglia	KELLY	7
Autonomic ganglia	KPNRTBM1	7.3
Autonomic ganglia	KPNSI9S	5
Autonomic ganglia	KPNYN	7.5
Autonomic ganglia	MHHNB11	4.8
Autonomic ganglia	NB1	5
Autonomic ganglia	NH6	6.3
Autonomic ganglia	SHSY5Y	7.5
Autonomic ganglia	SIMA	6.4
Autonomic ganglia	SKNAS	5.7
Autonomic ganglia	SKNBE2	5.7
Autonomic ganglia	SKNDZ	7.2
Autonomic ganglia	SKNFI	8.6
Autonomic ganglia	SKNSH	6.2
Biliary tract	HUCCT1	6.6
Biliary tract	HUH28	8.1
Biliary tract	SNU1079	8.6
Biliary tract	SNU1196	5.9
Biliary tract	SNU245	5.7
Biliary tract	SNU308	7.3
Biliary tract	SNU478	4.8
Bone	143B	7.7
Bone	A673	5.8
Bone	CADOES1	8.8
Bone	CAL78	8.4
Bone	G292CLONEA141B1	8.4
Bone	HOS	7.2
Bone	HS706T	7.4
Bone	HS737T	7.9
Bone	HS819T	7.8
Bone	HS821T	7.7
Bone	HS822T	7.8
Bone	HS863T	8.1
Bone	HS870T	7.8
Bone	HS888T	8.1
Bone	MG63	7.8
Bone	MHHES1	6.9
Bone	OUMS27	6.1
Bone	RDES	3.8
Bone	SJSA1	8.2
Bone	SKES1	5.3
Bone	SKNMC	5.2
Bone	SW1353	8.3
Bone	T173	7.6
Bone	TC71	7.1
Bone	U2OS	7.4
Breast	AU565	6.2
Breast	BT20	7.2
Breast	BT474	5.1
Breast	BT483	6.1
Breast	BT549	8.4
Breast	CAL120	8.3
Breast	CAL148	5.1
Breast	CAL51	9
Breast	CAL851	6.9
Breast	CAMA1	6.9
Breast	DU4475	7.7
Breast	EFM192A	7.3
Breast	EFM19	5.1
Breast	EVSAT	5.5
Breast	HCC1143	5.1
Breast	HCC1187	5.9
Breast	HCC1395	7.1
Breast	HCC1419	8.5
Breast	HCC1428	7.6
Breast	HCC1500	8.5
Breast	HCC1569	7.2
Breast	HCC1599	5.7
Breast	HCC1806	5.8
Breast	HCC1937	7.9
Breast	HCC1954	6.3
Breast	HCC202	6.9
Breast	HCC2157	5.8
Breast	HCC2218	5.7
Breast	HCC38	6.7
Breast	HCC70	6.9
Breast	HDQP1	7
Breast	HMC18	7.2
Breast	HS274T	7.4
Breast	HS281T	8.2
Breast	HS343T	8.4
Breast	HS578T	7.2
Breast	HS606T	8
Breast	HS739T	7.4
Breast	HS742T	7.1
Breast	JIMT1	6.1
Breast	KPL1	7.2
Breast	MCF7	8.3
Breast	MDAMB134VI	7.2
Breast	MDAMB157	7.4
Breast	MDAMB175VII	7.1
Breast	MDAMB231	8.1
Breast	MDAMB361	6.4
Breast	MDAMB415	6.6
Breast	MDAMB436	7.3
Breast	MDAMB453	6.3
Breast	MDAMB468	5.8
Breast	SKBR3	7.9
Breast	T47D	7.9
Breast	UACC812	6.7
Breast	UACC893	5.1
Breast	YMB1	7.4
Breast	ZR751	7.9
Breast	ZR7530	6.7
Central nervous system	1321N1	8.8
Central nervous system	42MGBA	6.9
Central nervous system	8MGBA	8
Central nervous system	A172	8.6
Central nervous system	AM38	8.2
Central nervous system	BECKER	7.6
Central nervous system	CAS1	8.1
Central nervous system	CCFSTTG1	7.7
Central nervous system	D283MED	5.9
Central nervous system	D341MED	8.3
Central nervous system	DAOY	6.1
Central nervous system	DBTRG05MG	8.6
Central nervous system	DKMG	8.5
Central nervous system	GAMG	8.2
Central nervous system	GB1	8
Central nervous system	GI1	7
Central nervous system	GMS10	8.9
Central nervous system	GOS3	9.1
Central nervous system	H4	5.2
Central nervous system	HS683	8.4
Central nervous system	KALS1	8.2
Central nervous system	KG1C	8.9
Central nervous system	KNS42	8.3
Central nervous system	KNS60	7.7
Central nervous system	KNS81	8.8
Central nervous system	KS1	8.6
Central nervous system	LN18	7.6
Central nervous system	LN229	9.5
Central nervous system	M059K	8.7
Central nervous system	MOGGCCM	9
Central nervous system	MOGGUVW	7.6
Central nervous system	NMCG1	9.2
Central nervous system	ONS76	8.3
Central nervous system	SF126	7.8
Central nervous system	SF295	7.2
Central nervous system	SNB19	9
Central nervous system	SNU1105	7.3
Central nervous system	SNU201	8.8
Central nervous system	SNU466	8.7
Central nervous system	SNU489	8.1
Central nervous system	SNU626	9.5
Central nervous system	SNU738	8.4
Central nervous system	SW1088	8.4
Central nervous system	SW1783	8.4
Central nervous system	T98G	7.5
Central nervous system	TM31	8.4
Central nervous system	U118MG	8.2
Central nervous system	U138MG	9.3
Central nervous system	U251MG	9.6
Central nervous system	U87MG	8.5
Central nervous system	YH13	8
Central nervous system	YKG1	9.4
Endometrium	AN3CA	8.1
Endometrium	COLO684	9.6
Endometrium	EFE184	6.4
Endometrium	EN	6.9
Endometrium	ESS1	7.4
Endometrium	HEC108	7.4
Endometrium	HEC151	6.5
Endometrium	HEC1A	9.5
Endometrium	HEC1B	9.7
Endometrium	HEC251	6.5
Endometrium	HEC265	7.5
Endometrium	HEC50B	8.4
Endometrium	HEC59	6.9
Endometrium	HEC6	9.4
Endometrium	ISHIKAWAHERAKLIO02ER	7.4
Endometrium	JHUEM1	8.3
Endometrium	JHUEM2	6.8
Endometrium	JHUEM3	7.1
Endometrium	KLE	7.3
Endometrium	MFE280	6.8
Endometrium	MFE296	6.7
Endometrium	MFE319	7.4
Endometrium	RL952	7.6
Endometrium	SNGM	7.4
Endometrium	SNU1077	5.5
Endometrium	SNU685	5.7
Endometrium	TEN	5
Haematopoietic and lymphoid	697	7.5
Haematopoietic and lymphoid	A3KAW	7.6
Haematopoietic and lymphoid	A4FUK	8.9
Haematopoietic and lymphoid	ALLSIL	9.8
Haematopoietic and lymphoid	AML193	8.1
Haematopoietic and lymphoid	AMO1	8.2
Haematopoietic and lymphoid	BCP1	6.9
Haematopoietic and lymphoid	BDCM	8.1
Haematopoietic and lymphoid	BL41	8.5
Haematopoietic and lymphoid	BL70	8.8
Haematopoietic and lymphoid	BV173	8.5
Haematopoietic and lymphoid	CA46	8
Haematopoietic and lymphoid	CI1	7.9
Haematopoietic and lymphoid	CMK115	8.2
Haematopoietic and lymphoid	CMK86	8.2
Haematopoietic and lymphoid	CMK	8.6
Haematopoietic and lymphoid	CMLT1	10
Haematopoietic and lymphoid	COLO775	7.8
Haematopoietic and lymphoid	DAUDI	10
Haematopoietic and lymphoid	DB	8.6
Haematopoietic and lymphoid	DEL	8
Haematopoietic and lymphoid	DND41	7.9
Haematopoietic and lymphoid	DOHH2	8.9
Haematopoietic and lymphoid	EB1	8.9
Haematopoietic and lymphoid	EB2	8.5
Haematopoietic and lymphoid	EHEB	8.4
Haematopoietic and lymphoid	EJM	9.5
Haematopoietic and lymphoid	EM2	7.9
Haematopoietic and lymphoid	EOL1	7.7
Haematopoietic and lymphoid	F36P	9.6
Haematopoietic and lymphoid	GA10	8
Haematopoietic and lymphoid	GDM1	6.7
Haematopoietic and lymphoid	GRANTA519	7.8
Haematopoietic and lymphoid	HDLM2	9
Haematopoietic and lymphoid	HDMYZ	8
Haematopoietic and lymphoid	HEL9217	8.2
Haematopoietic and lymphoid	HEL	8.6
Haematopoietic and lymphoid	HH	7.3
Haematopoietic and lymphoid	HL60	7.1
Haematopoietic and lymphoid	HPBALL	8.3
Haematopoietic and lymphoid	HS604T	8
Haematopoietic and lymphoid	HS611T	9
Haematopoietic and lymphoid	HS616T	7
Haematopoietic and lymphoid	HS751T	8.2
Haematopoietic and lymphoid	HT	9.5
Haematopoietic and lymphoid	HTK	6.9
Haematopoietic and lymphoid	HUNS1	7.8
Haematopoietic and lymphoid	HUT102	9.7
Haematopoietic and lymphoid	HUT78	7.3
Haematopoietic and lymphoid	JEKO1	8
Haematopoietic and lymphoid	JK1	10.9
Haematopoietic and lymphoid	JM1	8.2
Haematopoietic and lymphoid	JURKAT	8.8
Haematopoietic and lymphoid	JURLMK1	8.3
Haematopoietic and lymphoid	JVM2	9.4
Haematopoietic and lymphoid	JVM3	9.7
Haematopoietic and lymphoid	K562	8.8
Haematopoietic and lymphoid	KARPAS299	8.1
Haematopoietic and lymphoid	KARPAS422	9.7
Haematopoietic and lymphoid	KARPAS620	8.2
Haematopoietic and lymphoid	KASUMI1	7.2
Haematopoietic and lymphoid	KASUMI2	8.5
Haematopoietic and lymphoid	KASUMI6	8
Haematopoietic and lymphoid	KCL22	8.8
Haematopoietic and lymphoid	KE37	8.5
Haematopoietic and lymphoid	KE97	8.4
Haematopoietic and lymphoid	KG1	8.1
Haematopoietic and lymphoid	KHM1B	9.5
Haematopoietic and lymphoid	KIJK	7.7
Haematopoietic and lymphoid	KMH2	8.9
Haematopoietic and lymphoid	KMM1	7.8
Haematopoietic and lymphoid	KMS11	8.2
Haematopoietic and lymphoid	KMS12BM	7
Haematopoietic and lymphoid	KMS18	8.9
Haematopoietic and lymphoid	KMS20	7.3
Haematopoietic and lymphoid	KMS21BM	8
Haematopoietic and lymphoid	KMS26	9.8
Haematopoietic and lymphoid	KMS27	7.6
Haematopoietic and lymphoid	KMS28BM	7.6
Haematopoietic and lymphoid	KMS34	9.6
Haematopoietic and lymphoid	KO52	8.3
Haematopoietic and lymphoid	KOPN8	7.9
Haematopoietic and lymphoid	KU812	7.6
Haematopoietic and lymphoid	KYO1	8.4
Haematopoietic and lymphoid	L1236	7.4
Haematopoietic and lymphoid	L363	8.6
Haematopoietic and lymphoid	L428	7.5
Haematopoietic and lymphoid	L540	8.1
Haematopoietic and lymphoid	LAMA84	7.8
Haematopoietic and lymphoid	LOUCY	8.4
Haematopoietic and lymphoid	LP1	9.2
Haematopoietic and lymphoid	M07E	8.1
Haematopoietic and lymphoid	MC116	8.4
Haematopoietic and lymphoid	ME1	6.8
Haematopoietic and lymphoid	MEC1	8.3
Haematopoietic and lymphoid	MEC2	7.9
Haematopoietic and lymphoid	MEG01	6.1
Haematopoietic and lymphoid	MHHCALL2	9
Haematopoietic and lymphoid	MHHCALL3	9.1
Haematopoietic and lymphoid	MHHCALL4	8.5
Haematopoietic and lymphoid	MINO	6.9
Haematopoietic and lymphoid	MJ	10.1
Haematopoietic and lymphoid	MM1S	9.5
Haematopoietic and lymphoid	MOLM13	6
Haematopoietic and lymphoid	MOLM16	7.7
Haematopoietic and lymphoid	MOLM6	8.1
Haematopoietic and lymphoid	MOLP2	9.6
Haematopoietic and lymphoid	MOLP8	9.7
Haematopoietic and lymphoid	MOLT13	8.8
Haematopoietic and lymphoid	MOLT16	8.9
Haematopoietic and lymphoid	MOLT4	7.2
Haematopoietic and lymphoid	MONOMAC1	7.2
Haematopoietic and lymphoid	MONOMAC6	7.7
Haematopoietic and lymphoid	MOTN1	9.6
Haematopoietic and lymphoid	MUTZ5	7.8
Haematopoietic and lymphoid	MV411	7.1
Haematopoietic and lymphoid	NALM19	8.4
Haematopoietic and lymphoid	NALM1	8.7
Haematopoietic and lymphoid	NALM6	8.7
Haematopoietic and lymphoid	NAMALWA	7.8
Haematopoietic and lymphoid	NB4	7.1
Haematopoietic and lymphoid	NCIH929	9.5
Haematopoietic and lymphoid	NCO2	8.8
Haematopoietic and lymphoid	NOMO1	7.2
Haematopoietic and lymphoid	NUDHL1	7.8
Haematopoietic and lymphoid	NUDUL1	8.5
Haematopoietic and lymphoid	OCIAML2	8
Haematopoietic and lymphoid	OCIAML3	7.1
Haematopoietic and lymphoid	OCIAML5	7.9
Haematopoietic and lymphoid	OCILY10	9.2
Haematopoietic and lymphoid	OCILY19	8.6
Haematopoietic and lymphoid	OCILY3	8
Haematopoietic and lymphoid	OCIM1	8.8
Haematopoietic and lymphoid	OPM2	9.2
Haematopoietic and lymphoid	P12ICHIKAWA	6.8
Haematopoietic and lymphoid	P31FUJ	8.1
Haematopoietic and lymphoid	P3HR1	8.8
Haematopoietic and lymphoid	PCM6	10.1
Haematopoietic and lymphoid	PEER	7.3
Haematopoietic and lymphoid	PF382	8.8
Haematopoietic and lymphoid	PFEIFFER	8.8
Haematopoietic and lymphoid	PL21	9.4
Haematopoietic and lymphoid	RAJI	8.3
Haematopoietic and lymphoid	RCHACV	8
Haematopoietic and lymphoid	REC1	7.8
Haematopoietic and lymphoid	REH	7.9
Haematopoietic and lymphoid	RI1	8.3
Haematopoietic and lymphoid	RL	8.6
Haematopoietic and lymphoid	RPMI8226	8.1
Haematopoietic and lymphoid	RPMI8402	7.9
Haematopoietic and lymphoid	RS411	7.8
Haematopoietic and lymphoid	SEM	7.4
Haematopoietic and lymphoid	SET2	8.8
Haematopoietic and lymphoid	SIGM5	7.6
Haematopoietic and lymphoid	SKM1	7.8
Haematopoietic and lymphoid	SKMM2	8.4
Haematopoietic and lymphoid	SR786	8.7
Haematopoietic and lymphoid	ST486	7.6
Haematopoietic and lymphoid	SUDHL10	9
Haematopoietic and lymphoid	SUDHL1	8.3
Haematopoietic and lymphoid	SUDHL4	8.9
Haematopoietic and lymphoid	SUDHL5	9.2
Haematopoietic and lymphoid	SUDHL6	9.1
Haematopoietic and lymphoid	SUDHL8	7.8
Haematopoietic and lymphoid	SUPB15	7.7
Haematopoietic and lymphoid	SUPHD1	8.1
Haematopoietic and lymphoid	SUPM2	9
Haematopoietic and lymphoid	SUPT11	8.9
Haematopoietic and lymphoid	SUPT1	7.5
Haematopoietic and lymphoid	TALL1	6.8
Haematopoietic and lymphoid	TF1	6.1
Haematopoietic and lymphoid	THP1	8.2
Haematopoietic and lymphoid	TO175T	6.8
Haematopoietic and lymphoid	TOLEDO	7.5
Haematopoietic and lymphoid	U266B1	8.9
Haematopoietic and lymphoid	U937	8.1
Haematopoietic and lymphoid	UT7	9.2
Haematopoietic and lymphoid	WSUDLCL2	9.4
Kidney	769P	6.8
Kidney	786O	6.2
Kidney	A498	7.3
Kidney	A704	9.3
Kidney	ACHN	7.5
Kidney	BFTC909	6.8
Kidney	CAKI1	7.3
Kidney	CAKI2	5.1
Kidney	CAL54	7
Kidney	KMRC1	7.5
Kidney	KMRC20	8.5
Kidney	KMRC2	6.7
Kidney	KMRC3	7.9
Kidney	OSRC2	7.7
Kidney	RCC10RGB	7.2
Kidney	SNU1272	7.1
Kidney	SNU349	7.7
Kidney	TUHR10TKB	7.6
Kidney	TUHR14TKB	8
Kidney	TUHR4TKB	8.4
Kidney	VMRCRCW	7.7
Kidney	VMRCRCZ	6.8
Large intestine	C2BBE1	6.5
Large intestine	CCK81	5.3
Large intestine	CL11	8.3
Large intestine	CL14	8.5
Large intestine	CL34	7.7
Large intestine	CL40	6.5
Large intestine	COLO205	4.5
Large intestine	COLO320	7.2
Large intestine	COLO678	8
Large intestine	CW2	6.4
Large intestine	DLD1	8.6
Large intestine	GP2D	5.9
Large intestine	HCC56	6.5
Large intestine	HCT116	5.9
Large intestine	HCT15	7.9
Large intestine	HS675T	8.2
Large intestine	HS698T	7.4
Large intestine	HT115	5.1
Large intestine	HT29	5.3
Large intestine	HT55	8.2
Large intestine	KM12	7.4
Large intestine	LOVO	7.8
Large intestine	LS1034	5.3
Large intestine	LS123	7.5
Large intestine	LS180	7.2
Large intestine	LS411N	6.5
Large intestine	LS513	6.2
Large intestine	MDST8	7.4
Large intestine	NCIH508	5.7
Large intestine	NCIH716	8.3
Large intestine	NCIH747	6.4
Large intestine	OUMS23	7.7
Large intestine	RCM1	5.3
Large intestine	RKO	7.8
Large intestine	SKCO1	4.9
Large intestine	SNU1040	7.4
Large intestine	SNU1197	5.9
Large intestine	SNU175	7
Large intestine	SNU283	7.5
Large intestine	SNU407	6.5
Large intestine	SNU503	6.1
Large intestine	SNU61	6.2
Large intestine	SNU81	6.7
Large intestine	SNUC1	8
Large intestine	SNUC2A	6.7
Large intestine	SNUC4	7.3
Large intestine	SNUC5	6.8
Large intestine	SW1116	4.2
Large intestine	SW1417	5.9
Large intestine	SW1463	5.5
Large intestine	SW403	6.4
Large intestine	SW480	6.2
Large intestine	SW48	5.4
Large intestine	SW620	5.8
Large intestine	SW837	5.6
Large intestine	SW948	7.6
Large intestine	T84	7.4
Liver	ALEXANDERCELLS	7.4
Liver	C3A	4.9
Liver	HEP3B217	7.7
Liver	HEPG2	5.6
Liver	HLE	10.4
Liver	HLF	8.2
Liver	HUH1	6.7
Liver	HUH6	6.7
Liver	HUH7	7.2
Liver	JHH1	5.5
Liver	JHH2	7.2
Liver	JHH4	7
Liver	JHH5	5.3
Liver	JHH6	8.4
Liver	JHH7	6.3
Liver	LI7	8.5
Liver	PLCPRF5	6.8
Liver	SKHEP1	7.5
Liver	SNU182	8.8
Liver	SNU387	6.7
Liver	SNU398	8.1
Liver	SNU423	8.3
Liver	SNU449	8.1
Liver	SNU475	7.3
Liver	SNU761	8.4
Liver	SNU878	8.4
Liver	SNU886	8.4
Lung	A549	7.6
Lung	ABC1	7.5
Lung	BEN	7.3
Lung	CAL12T	7.3
Lung	CALU1	8
Lung	CALU3	7.5
Lung	CALU6	6.8
Lung	CHAGOK1	8.3
Lung	COLO668	7.6
Lung	COLO699	10.3
Lung	CORL105	7.9
Lung	CORL23	5.6
Lung	CORL24	8.7
Lung	CORL279	4.7
Lung	CORL311	10.7
Lung	CORL47	6.4
Lung	CORL51	8
Lung	CORL88	6.2
Lung	CORL95	8.4
Lung	CPCN	7.5
Lung	DMS114	7.6
Lung	DMS153	6.7
Lung	DMS273	7.6
Lung	DMS454	6.5
Lung	DMS53	5
Lung	DMS79	6.7
Lung	DV90	7.4
Lung	EBC1	6.4
Lung	EPLC272H	5.3
Lung	HARA	6
Lung	HCC1171	6.6
Lung	HCC1195	7.1
Lung	HCC15	7.4
Lung	HCC2279	8.5
Lung	HCC2935	5.9
Lung	HCC33	6.5
Lung	HCC366	8.3
Lung	HCC4006	8.1
Lung	HCC44	6
Lung	HCC78	6.7
Lung	HCC827	6.2
Lung	HCC95	5.6
Lung	HLC1	8.6
Lung	HLFA	8
Lung	HS229T	7.5
Lung	HS618T	7.2
Lung	IALM	7.9
Lung	KNS62	5.7
Lung	LC1F	7.4
Lung	LC1SQSF	7.1
Lung	LCLC103H	8.6
Lung	LCLC97TM1	6.7
Lung	LK2	5.6
Lung	LOUNH91	7.8
Lung	LU65	7
Lung	LU99	7
Lung	LUDLU1	5.4
Lung	LXF289	7
Lung	MORCPR	7.6
Lung	NCIH1048	9.8
Lung	NCIH1092	7.8
Lung	NCIH1105	6.7
Lung	NCIH1155	8
Lung	NCIH1184	7.8
Lung	NCIH1299	8.4
Lung	NCIH1339	8.4
Lung	NCIH1341	7.6
Lung	NCIH1355	7.7
Lung	NCIH1373	6.6
Lung	NCIH1385	6.7
Lung	NCIH1395	6.5
Lung	NCIH1435	6.8
Lung	NCIH1436	7.9
Lung	NCIH1437	5.9
Lung	NCIH146	7.4
Lung	NCIH1563	9
Lung	NCIH1568	6.7
Lung	NCIH1573	6.4
Lung	NCIH1581	7.6
Lung	NCIH1618	7.1
Lung	NCIH1623	6.6
Lung	NCIH1648	5.4
Lung	NCIH1650	9.6
Lung	NCIH1651	7.8
Lung	NCIH1666	5.1
Lung	NCIH1693	6.7
Lung	NCIH1694	7.5
Lung	NCIH1703	8.8
Lung	NCIH1734	7.7
Lung	NCIH1755	6.5
Lung	NCIH1781	7.9
Lung	NCIH1792	7.5
Lung	NCIH1793	8.9
Lung	NCIH1836	5.7
Lung	NCIH1838	6.6
Lung	NCIH1869	6.3
Lung	NCIH1876	8
Lung	NCIH1915	8.2
Lung	NCIH1930	8
Lung	NCIH1944	7.5
Lung	NCIH1963	6.8
Lung	NCIH196	8.4
Lung	NCIH1975	6.5
Lung	NCIH2009	6.2
Lung	NCIH2023	7.1
Lung	NCIH2029	7.8
Lung	NCIH2030	8.2
Lung	NCIH2066	7.9
Lung	NCIH2081	8.1
Lung	NCIH2085	6.4
Lung	NCIH2087	6.9
Lung	NCIH209	6.5
Lung	NCIH2106	8.5
Lung	NCIH2110	6.5
Lung	NCIH211	10.8
Lung	NCIH2122	5.9
Lung	NCIH2126	4.2
Lung	NCIH2141	7.6
Lung	NCIH2170	5.6
Lung	NCIH2171	5.2
Lung	NCIH2172	7.2
Lung	NCIH2196	7
Lung	NCIH2227	6.7
Lung	NCIH2228	6.9
Lung	NCIH226	9.4
Lung	NCIH2286	6.2
Lung	NCIH2291	6.1
Lung	NCIH2342	6.8
Lung	NCIH2347	7.3
Lung	NCIH23	6.7
Lung	NCIH2405	8.1
Lung	NCIH2444	6.3
Lung	NCIH292	5.1
Lung	NCIH322	8.3
Lung	NCIH3255	6
Lung	NCIH358	5
Lung	NCIH441	7.1
Lung	NCIH446	7.6
Lung	NCIH460	6.5
Lung	NCIH510	5.7
Lung	NCIH520	6.4
Lung	NCIH522	6.9
Lung	NCIH524	6.5
Lung	NCIH526	10.7
Lung	NCIH596	9.8
Lung	NCIH647	5.3
Lung	NCIH650	8.6
Lung	NCIH661	7.2
Lung	NCIH69	5.3
Lung	NCIH727	5.6
Lung	NCIH810	5.8
Lung	NCIH82	7.9
Lung	NCIH838	9.3
Lung	NCIH841	7.7
Lung	NCIH854	7.4
Lung	NCIH889	5.5
Lung	PC14	5.5
Lung	RERFLCAD1	7.4
Lung	RERFLCAD2	6.9
Lung	RERFLCAI	8
Lung	RERFLCKJ	7.4
Lung	RERFLCMS	8
Lung	RERFLCSQ1	7.2
Lung	SBC5	8
Lung	SCLC21H	5.9
Lung	SHP77	7.5
Lung	SKLU1	7.2
Lung	SKMES1	8.5
Lung	SQ1	6
Lung	SW1271	9
Lung	SW1573	8.3
Lung	SW900	6.8
Lung	VMRCLCD	5
Lung	VMRCLCP	4.7
Oesophagus	COLO680N	5.7
Oesophagus	ECGI10	4.7
Oesophagus	KYSE140	7.8
Oesophagus	KYSE150	7.7
Oesophagus	KYSE180	6.1
Oesophagus	KYSE270	5.9
Oesophagus	KYSE30	7.1
Oesophagus	KYSE410	7.5
Oesophagus	KYSE450	6.6
Oesophagus	KYSE510	5
Oesophagus	KYSE520	7.5
Oesophagus	KYSE70	8.4
Oesophagus	OE19	7.4
Oesophagus	OE33	6.4
Oesophagus	TE10	6.6
Oesophagus	TE11	6.3
Oesophagus	TE14	5.1
Oesophagus	TE15	6.1
Oesophagus	TE1	7.1
Oesophagus	TE4	6.5
Oesophagus	TE5	7.2
Oesophagus	TE6	5.7
Oesophagus	TE8	6.6
Oesophagus	TE9	5.5
Oesophagus	TT	6.2
Ovary	59M	7.6
Ovary	A2780	5.4
Ovary	CAOV3	5.5
Ovary	CAOV4	6.3
Ovary	COLO704	8.7
Ovary	COV318	7.3
Ovary	COV362	8.6
Ovary	COV434	8.7
Ovary	COV504	7.8
Ovary	COV644	5.7
Ovary	EFO21	6.6
Ovary	EFO27	5.5
Ovary	ES2	7.5
Ovary	FUOV1	6.6
Ovary	HEYA8	7.7
Ovary	HS571T	7.5
Ovary	IGROV1	5.6
Ovary	JHOC5	7.6
Ovary	JHOM1	8.3
Ovary	JHOM2B	7.9
Ovary	JHOS2	8.8
Ovary	JHOS4	8.9
Ovary	KURAMOCHI	7.3
Ovary	MCAS	5.5
Ovary	NIHOVCAR3	6.9
Ovary	OAW28	8.2
Ovary	OAW42	7.5
Ovary	OC314	8.2
Ovary	OC316	7.4
Ovary	ONCODG1	7.6
Ovary	OV56	7.2
Ovary	OV7	7.2
Ovary	OV90	5.7
Ovary	OVCAR4	7.6
Ovary	OVCAR8	8
Ovary	OVISE	5.6
Ovary	OVK18	8.7
Ovary	OVKATE	7.5
Ovary	OVMANA	5.9
Ovary	OVSAHO	7
Ovary	OVTOKO	8.6
Ovary	RMGI	5.3
Ovary	RMUGS	6
Ovary	SKOV3	7.5
Ovary	SNU119	8.9
Ovary	SNU840	7
Ovary	SNU8	6
Ovary	TOV112D	6.8
Ovary	TOV21G	8.7
Ovary	TYKNU	7.6
Pancreas	ASPC1	6
Pancreas	BXPC3	7.4
Pancreas	CAPAN1	7
Pancreas	CAPAN2	6.6
Pancreas	CFPAC1	6.1
Pancreas	DANG	6.1
Pancreas	HPAC	6.3
Pancreas	HPAFII	5.7
Pancreas	HS766T	7.7
Pancreas	HUPT3	6.4
Pancreas	HUPT4	9.6
Pancreas	KCIMOH1	4.8
Pancreas	KLM1	6.4
Pancreas	KP2	7.2
Pancreas	KP3	9.3
Pancreas	KP4	8.2
Pancreas	L33	6.5
Pancreas	MIAPACA2	7.1
Pancreas	PANC0203	5.1
Pancreas	PANC0213	6.2
Pancreas	PANC0327	7.7
Pancreas	PANC0403	6.7
Pancreas	PANC0504	7.1
Pancreas	PANC0813	6.2
Pancreas	PANC1005	5.5
Pancreas	PANC1	8.4
Pancreas	PATU8902	6.9
Pancreas	PATU8988S	7.6
Pancreas	PATU8988T	7.9
Pancreas	PK1	6.8
Pancreas	PK45H	9.5
Pancreas	PK59	6.2
Pancreas	PL45	5.5
Pancreas	PSN1	6.8
Pancreas	QGP1	6.9
Pancreas	SNU213	6.6
Pancreas	SNU324	7.2
Pancreas	SNU410	7.5
Pancreas	SU8686	5.6
Pancreas	SUIT2	9.1
Pancreas	SW1990	7.1
Pancreas	T3M4	6.6
Pancreas	TCCPAN2	7.8
Pancreas	YAPC	6.8
Pleura	ACCMESO1	8.6
Pleura	DM3	8
Pleura	ISTMES1	9.8
Pleura	ISTMES2	9.3
Pleura	JL1	7.5
Pleura	MPP89	7.8
Pleura	MSTO211H	7.1
Pleura	NCIH2052	7.7
Pleura	NCIH2452	7.5
Pleura	NCIH28	7.8
Prostate	22RV1	7.7
Prostate	DU145	7.1
Prostate	LNCAPCLONEFGC	7.8
Prostate	MDAPCA2B	9.4
Prostate	NCIH660	7
Prostate	PC3	7.3
Prostate	VCAP	8.4
Salivary gland	A253	7
Salivary gland	YD15	5.4
Skin	A101D	10.4
Skin	A2058	9.7
Skin	A375	8.7
Skin	C32	10.7
Skin	CHL1	6.4
Skin	CJM	6.7
Skin	COLO679	10.1
Skin	COLO741	9
Skin	COLO783	11
Skin	COLO792	11.2
Skin	COLO800	10.2
Skin	COLO818	10.7
Skin	COLO829	10.5
Skin	COLO849	10.5
Skin	G361	9.1
Skin	GRM	6.5
Skin	HMCB	7
Skin	HS294T	11.5
Skin	HS600T	7.8
Skin	HS688AT	8.4
Skin	HS695T	6.9
Skin	HS839T	8
Skin	HS852T	11.2
Skin	HS895T	7.9
Skin	HS934T	8
Skin	HS936T	9.5
Skin	HS939T	10.6
Skin	HS940T	7
Skin	HS944T	10.8
Skin	HT144	10.6
Skin	IGR1	9.3
Skin	IGR37	9.6
Skin	IGR39	7.5
Skin	IPC298	10.8
Skin	K029AX	10.6
Skin	LOXIMVI	7.3
Skin	MALME3M	10.1
Skin	MDAMB435S	10.4
Skin	MELHO	9.4
Skin	MELJUSO	10.8
Skin	MEWO	11
Skin	RPMI7951	8.4
Skin	RVH421	10.8
Skin	SH4	9.4
Skin	SKMEL1	9.7
Skin	SKMEL24	10.4
Skin	SKMEL28	10.3
Skin	SKMEL2	10.6
Skin	SKMEL30	10.5
Skin	SKMEL31	10.3
Skin	SKMEL3	11.2
Skin	SKMEL5	10.6
Skin	UACC257	9.4
Skin	UACC62	9.3
Skin	WM115	10.2
Skin	WM1799	11.3
Skin	WM2664	11.4
Skin	WM793	8.5
Skin	WM88	10.9
Skin	WM983B	10.5
Small intestine	HUTU80	7.4
Soft tissue	A204	5.3
Soft tissue	G401	5.8
Soft tissue	G402	6.5
Soft tissue	GCT	8.3
Soft tissue	HS729	7.6
Soft tissue	HT1080	8.3
Soft tissue	KYM1	5.7
Soft tissue	MESSA	7
Soft tissue	RD	6.2
Soft tissue	RH30	6.5
Soft tissue	RH41	7.1
Soft tissue	RKN	7.8
Soft tissue	S117	8.8
Soft tissue	SJRH30	6.6
Soft tissue	SKLMS1	8.3
Soft tissue	SKUT1	5
Soft tissue	TE125T	7.7
Soft tissue	TE159T	8.5
Soft tissue	TE441T	10.1
Soft tissue	TE617T	8.3
Stomach	2313287	5.3
Stomach	AGS	7.1
Stomach	AZ521	7.3
Stomach	ECC10	7
Stomach	ECC12	9
Stomach	FU97	5.4
Stomach	GCIY	7.3
Stomach	GSS	6.9
Stomach	GSU	6.3
Stomach	HGC27	5.4
Stomach	HS746T	8.2
Stomach	HUG1N	7.1
Stomach	IM95	8
Stomach	KATOIII	7.4
Stomach	KE39	6.5
Stomach	LMSU	7.1
Stomach	MKN1	7.4
Stomach	MKN45	7.7
Stomach	MKN74	8
Stomach	MKN7	6
Stomach	NCCSTCK140	8.7
Stomach	NCIN87	6.7
Stomach	NUGC2	6.6
Stomach	NUGC3	6.2
Stomach	NUGC4	6.4
Stomach	OCUM1	5.2
Stomach	RERFGC1B	8.3
Stomach	SH10TC	6.3
Stomach	SNU16	4.4
Stomach	SNU1	9
Stomach	SNU216	8.4
Stomach	SNU520	8.5
Stomach	SNU5	8.3
Stomach	SNU601	7.6
Stomach	SNU620	6.9
Stomach	SNU668	8.1
Stomach	SNU719	7.7
Stomach	TGBC11TKB	8.3
Thyroid	8305C	6.6
Thyroid	8505C	9.4
Thyroid	BCPAP	6.8
Thyroid	BHT101	7.7
Thyroid	CAL62	6.3
Thyroid	CGTHW1	7.7
Thyroid	FTC133	7.5
Thyroid	FTC238	8.5
Thyroid	ML1	7
Thyroid	SW579	7.8
Thyroid	TT2609C02	7.6
Thyroid	TT	8.3
Upper aerodigestive tract	BHY	6.1
Upper aerodigestive tract	BICR16	5.7
Upper aerodigestive tract	BICR18	6
Upper aerodigestive tract	BICR22	6.4
Upper aerodigestive tract	BICR31	5.9
Upper aerodigestive tract	BICR56	5.4
Upper aerodigestive tract	BICR6	5.8
Upper aerodigestive tract	CAL27	5.2
Upper aerodigestive tract	CAL33	6.1
Upper aerodigestive tract	DETROIT562	6.1
Upper aerodigestive tract	FADU	6.4
Upper aerodigestive tract	HS840T	7.8
Upper aerodigestive tract	HSC2	7.5
Upper aerodigestive tract	HSC3	5.3
Upper aerodigestive tract	HSC4	7.9
Upper aerodigestive tract	PECAPJ15	6.6
Upper aerodigestive tract	PECAPJ34CLONEC12	5.8
Upper aerodigestive tract	PECAPJ41CLONED2	4.7
Upper aerodigestive tract	PECAPJ49	6.5
Upper aerodigestive tract	SCC15	6.2
Upper aerodigestive tract	SCC25	5.7
Upper aerodigestive tract	SCC4	5.4
Upper aerodigestive tract	SCC9	7
Upper aerodigestive tract	SNU1076	6.9
Upper aerodigestive tract	SNU1214	7
Upper aerodigestive tract	SNU46	6.9
Upper aerodigestive tract	SNU899	6.5
Upper aerodigestive tract	YD10B	5.3
Upper aerodigestive tract	YD38	5.8
Upper aerodigestive tract	YD8	8.1
Urinary tract	5637	6.4
Urinary tract	639V	7.9
Urinary tract	647V	7.7
Urinary tract	BC3C	7
Urinary tract	BFTC905	4.7
Urinary tract	CAL29	7.2
Urinary tract	HS172T	8.5
Urinary tract	HT1197	6.6
Urinary tract	HT1376	8
Urinary tract	J82	7.8
Urinary tract	JMSU1	8.8
Urinary tract	KMBC2	5.2
Urinary tract	KU1919	7.9
Urinary tract	RT11284	8.1
Urinary tract	RT112	7.7
Urinary tract	RT4	8.2
Urinary tract	SCABER	5
Urinary tract	SW1710	7.1
Urinary tract	SW780	7.3
Urinary tract	T24	8.1
Urinary tract	TCCSUP	7.7
Urinary tract	UMUC1	6.2
Urinary tract	UMUC3	8.8
Urinary tract	VMCUB1	5.8

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	18
Adrenal gland	11.9
Appendix	19.3
Bone marrow	26.8
Breast	11.6
Cerebral cortex	45.4
Cervix, uterine	20.6
Colon	10.5
Duodenum	16.6
Endometrium	18.1
Epididymis	8.8
Esophagus	27.4
Fallopian tube	17.3
Gallbladder	18
Heart muscle	22.5
Kidney	16.2
Liver	18.4
Lung	22.2
Lymph node	23.8
Ovary	30.9
Pancreas	3.5
Parathyroid gland	83.6
Placenta	17.6
Prostate	20.6
Rectum	12.7
Salivary gland	13.8
Seminal vesicle	16.4
Skeletal muscle	19.3
Skin	15.5
Small intestine	22.1
Smooth muscle	17.9
Spleen	25.3
Stomach	11.6
Testis	4.7
Thyroid gland	21.9
Tonsil	17.3
Urinary bladder	14.7

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27453350	Overexpression	Alveolar Rhabdomyosarcoma	The present work shows that the histone acetyltransferase P/CAF (KAT2B) is overexpressed in primary tumours from ARMS patients.
26945969	Underexpression	Hepatocellular Carcinoma	In present research, we detected that PCAF was down-regulated in hepatocellular carcinoma (HCC) tissues compared with the adjacent non-tumor tissues and significantly associated with malignant portal vein invasion (p<0.05) and poor survival (p<0.05) of HCC patients.
25855960	Underexpression	Hepatocellular Carcinoma	Gene expression microarray studies showed that PCAF was downregulated in HCC tissues compared with adjacent liver tissues and that PCAF expression was significantly associated with longer overall survival and recurrence-free survival after surgery.
24668547	Underexpression	Gastric Carcinoma	Our results demonstrated downregulation of HDAC1, PCAF, and CDKN1A in gastric tumors compared with adjacent nontumors (P < 0.05).
23981651	Underexpression	Hepatocellular Carcinoma	PCAF was found to be expressed at the low level in most of HCC cell lines.
23643089	Underexpression	Hepatocellular Carcinoma	PCAF expression is down-regulated in HCC and constitutes a promising biomarker for the prognosis after curative liver resection.
23095762	Overexpression	Pancreatic Carcinoma	PCAF was upregulated in several PCa cell lines.
20026908	Underexpression	Gastric Carcinoma; intestinal type Gastric Carcinoma	The expression of PCAF was markedly down-regulated in GC cell lines and ITGC tissues.
28418886	Loss of Expression	Colon Carcinoma	Finally we identified loss of PCAF expression in tumor samples and showed that forced expression of PCAF in colon cancer cell lines restored CXCL12 expression.
28053092	Overexpression	acute promyelocyticLeukemia	We found that PCAF expression was markedly increased in leukemia cell lines (NB4 and HL-60) and primary APL cells during ATRA-induced granulocytic differentiation.
28042499	Underexpression	Gastric Carcinoma	We showed that both PCAF mRNA and protein were downregulated in GC cells, and that this downregulation correlated with poor survival.
27453350	Overexpression	Alveolar rhabdomyosarcoma	The present work shows that the histone acetyltransferase P/CAF (KAT2B) is overexpressed in primary tumours from ARMS patients.

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.484	4.64e-25	16.1	45.8	38.1	Gain
BRCA	Breast invasive carcinoma	1075	0.224	1.23e-13	18	65.5	16.5	Neutral
CESC	Cervical and endocervical cancers	292	0.231	6.69e-05	38	50.7	11.3	Loss
COAD	Colon adenocarcinoma	449	0.179	0.000133	14.9	76.2	8.9	Neutral
ESCA	Esophageal carcinoma	183	0.369	2.8e-07	59	33.3	7.7	Loss
GBM	Glioblastoma multiforme	147	0.166	0.0446	7.5	78.9	13.6	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.507	6.32e-35	68.9	28.2	2.9	Loss
KIRC	Kidney renal clear cell carcinoma	525	0.158	0.000273	87.6	11.4	1	Loss
KIRP	Kidney renal papillary cell carcinoma	288	0.081	0.172	8	67	25	Neutral
LAML	Acute Myeloid Leukemia	166	0.112	0.15	3	96.4	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	0.189	1.66e-05	6.2	90.1	3.7	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.219	2.51e-05	14.3	73.6	12.1	Neutral
LUAD	Lung adenocarcinoma	512	0.363	2.31e-17	45.7	47.5	6.8	Loss
LUSC	Lung squamous cell carcinoma	498	0.396	4.13e-20	81.7	14.7	3.6	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.321	1.3e-08	34.7	42.7	22.7	Loss
PAAD	Pancreatic adenocarcinoma	177	0.308	3.01e-05	23.7	70.6	5.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.385	4.07e-07	38.3	59.9	1.9	Loss
PRAD	Prostate adenocarcinoma	491	0.092	0.0406	3.3	88.8	7.9	Neutral
READ	Rectum adenocarcinoma	164	0.182	0.0197	12.2	72.6	15.2	Neutral
SARC	Sarcoma	255	0.299	1.16e-06	13.3	62.4	24.3	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.146	0.00501	19.9	62.7	17.4	Neutral
STAD	Stomach adenocarcinoma	413	0.258	9.94e-08	29.5	62	8.5	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.028	0.735	26	56.7	17.3	Neutral
THCA	Thyroid carcinoma	497	-0.058	0.197	0.8	98.6	0.6	Neutral
THYM	Thymoma	119	0.263	0.00384	11.8	88.2	0	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.256	1.87e-09	11.5	78.2	10.2	Neutral

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.233	1.26e-06	17	408	-0.003	0.393	NS/NA
BRCA	Breast invasive carcinoma	-0.25	1.02e-13	83	785	0.002	5.84e-15	NS/NA
CESC	Cervical and endocervical cancers	-0.251	8.6e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.213	0.000142	19	297	0.003	0.00443	NS/NA
ESCA	Esophageal carcinoma	-0.338	1.65e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.24	0.0546	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.234	3.97e-08	20	522	0.005	0.00129	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.209	9.61e-05	24	319	0.012	1.42e-08	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.269	2.79e-06	23	275	0.002	0.569	NS/NA
LAML	Acute Myeloid Leukemia	-0.081	0.295	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.146	0.00076	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.194	7.12e-05	41	373	0.003	0.214	NS/NA
LUAD	Lung adenocarcinoma	-0.054	0.243	21	456	-0.002	0.643	NS/NA
LUSC	Lung squamous cell carcinoma	-0.257	4.49e-07	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.533	0.148	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.268	0.000256	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.37	2.36e-07	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.079	0.0672	35	498	-0.003	0.712	NS/NA
READ	Rectum adenocarcinoma	-0.288	0.00366	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.257	2.69e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.105	0.0225	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.233	5.78e-06	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.254	0.00143	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.054	0.199	50	509	0	0.401	NS/NA
THYM	Thymoma	-0.2	0.0274	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.109	0.0186	34	431	0	0.0235	NS/NA

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	1	Low
Bone marrow	2	Medium
Breast	1	Low
Bronchus	2	Medium
Caudate	2	Medium
Cerebellum	3	High
Cerebral cortex	2	Medium
Cervix, uterine	1	Low
Colon	2	Medium
Duodenum	2	Medium
Endometrium	1	Low
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	2	Medium
Gallbladder	2	Medium
Heart muscle	1	Low
Hippocampus	2	Medium
Kidney	2	Medium
Liver	1	Low
Lung	2	Medium
Lymph node	1	Low
Nasopharynx	2	Medium
Oral mucosa	1	Low
Ovary	2	Medium
Pancreas	2	Medium
Parathyroid gland	2	Medium
Placenta	3	High
Prostate	2	Medium
Rectum	2	Medium
Salivary gland	3	High
Seminal vesicle	1	Low
Skeletal muscle	2	Medium
Skin	2	Medium
Small intestine	2	Medium
Smooth muscle	1	Low
Soft tissue	2	Medium
Spleen	2	Medium
Stomach	3	High
Testis	1	Low
Thyroid gland	3	High
Tonsil	2	Medium
Urinary bladder	3	High
Vagina	1	Low

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.849	NS	24476821
BRCA	Breast invasive carcinoma	521	0.318	NS	23000897
COAD	Colon adenocarcinoma	149	0.00036	Significant	22810696
GBM	Glioblastoma multiforme	157	0.00428	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.27e-11	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.128	NS	26536169
LGG	Brain Lower Grade Glioma	513	0.000544	Significant	26824661
LUAD	Lung adenocarcinoma	230	7.3e-08	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.000468	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1.24e-12	Significant	21720365
PRAD	Prostate adenocarcinoma	333	4.3e-05	Significant	26544944
READ	Rectum adenocarcinoma	67	0.918	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.000926	Significant	26091043
STAD	Stomach adenocarcinoma	277	1.67e-09	Significant	25079317
THCA	Thyroid carcinoma	391	4.01e-12	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.156	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.713	0.101	NS
BRCA	Breast invasive carcinoma	1079	1.229	0.367	NS
CESC	Cervical and endocervical cancers	291	0.51	0.0438	Longer
COAD	Colon adenocarcinoma	439	0.742	0.286	NS
ESCA	Esophageal carcinoma	184	1.049	0.88	NS
GBM	Glioblastoma multiforme	158	0.723	0.196	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.551	0.00261	Longer
KIRC	Kidney renal clear cell carcinoma	531	0.463	0.000296	Longer
KIRP	Kidney renal papillary cell carcinoma	287	0.532	0.167	NS
LAML	Acute Myeloid Leukemia	149	1.224	0.507	NS
LGG	Brain Lower Grade Glioma	511	0.75	0.252	NS
LIHC	Liver hepatocellular carcinoma	365	0.746	0.232	NS
LUAD	Lung adenocarcinoma	502	0.59	0.0176	Longer
LUSC	Lung squamous cell carcinoma	494	1.429	0.0727	NS
OV	Ovarian serous cystadenocarcinoma	303	0.838	0.421	NS
PAAD	Pancreatic adenocarcinoma	177	0.656	0.166	NS
PCPG	Pheochromocytoma and Paraganglioma	179	4.667	0.124	NS
PRAD	Prostate adenocarcinoma	497	4.385	0.177	NS
READ	Rectum adenocarcinoma	159	0.697	0.516	NS
SARC	Sarcoma	259	0.87	0.604	NS
SKCM	Skin Cutaneous Melanoma	459	0.583	0.00457	Longer
STAD	Stomach adenocarcinoma	388	1.257	0.288	NS
TGCT	Testicular Germ Cell Tumors	134	751928555.735	0.265	NS
THCA	Thyroid carcinoma	500	1.107	0.867	NS
THYM	Thymoma	119	0.552	0.517	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.983	0.954	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.011	0.829	NS
BRCA	Breast invasive carcinoma	1071	0.035	0.254	NS
CESC	Cervical and endocervical cancers	167	0.1	0.2	NS
COAD	Colon adenocarcinoma	445	-0.104	0.0283	Lower
ESCA	Esophageal carcinoma	162	0.109	0.169	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.123	0.00919	Lower
KIRC	Kidney renal clear cell carcinoma	531	-0.115	0.00787	Lower
KIRP	Kidney renal papillary cell carcinoma	260	-0.045	0.47	NS
LIHC	Liver hepatocellular carcinoma	347	-0.061	0.259	NS
LUAD	Lung adenocarcinoma	507	-0.126	0.00457	Lower
LUSC	Lung squamous cell carcinoma	497	-0.057	0.207	NS
OV	Ovarian serous cystadenocarcinoma	302	0.101	0.0787	NS
PAAD	Pancreatic adenocarcinoma	176	-0.039	0.611	NS
READ	Rectum adenocarcinoma	156	0.066	0.416	NS
SKCM	Skin Cutaneous Melanoma	410	-0.066	0.182	NS
STAD	Stomach adenocarcinoma	392	0.068	0.176	NS
TGCT	Testicular Germ Cell Tumors	81	-0.399	0.000228	Lower
THCA	Thyroid carcinoma	499	-0.054	0.23	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.064	0.156	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.167	0.00576	Lower
HNSC	Head and Neck squamous cell carcinoma	498	-0.082	0.0663	NS
KIRC	Kidney renal clear cell carcinoma	525	-0.095	0.0288	Lower
LGG	Brain Lower Grade Glioma	514	-0.155	0.000406	Lower
LIHC	Liver hepatocellular carcinoma	366	-0.232	7.37e-06	Lower
OV	Ovarian serous cystadenocarcinoma	296	0.05	0.39	NS
PAAD	Pancreatic adenocarcinoma	176	-0.081	0.287	NS
STAD	Stomach adenocarcinoma	406	0.231	2.68e-06	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.033	0.44	NS

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database

[ TOP ]

DrugBank ID	Name	Type
DB01992	Coenzyme A	Small Molecule Drug
DB08186	(3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE	Small Molecule Drug
DB08291	N-(3-AMINOPROPYL)-2-NITROBENZENAMINE	Small Molecule Drug

Summary
Symbol	KAT2B
Name	lysine acetyltransferase 2B
Aliases	P/CAF; GCN5L; PCAF; p300/CBP-associated factor; CAF; CREBBP-associated factor; histone acetylase PCAF; histo ......
Location	3p24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
27453350	Alveolar Rhabdomyosarcoma	downstream	PAX3-FOXO1	Positive regulation	Silencing P/CAF, or pharmacological inhibition of its acetyltransferase activity, down-regulates PAX3-FOXO1 levels concomitant with reduced proliferation and tumour burden in xenograft mouse models.
26945969	Hepatocellular Carcinoma	downstream	Gli1	Negative regulation	PCAF is an anti-oncogene that plays an important role in the development of HCC by suppressing HCC cell metastasis and EMT by targeting Gli1, which indicates the potential therapeutic value of PCAF for suppression of metastasis of HCC.
25855960	Hepatocellular Carcinoma	downstream	Bcl-2; BAX; GLI1	Negative regulation; positive regulation; regulation	Interestingly, forced expression of PCAF reduced Bcl-2 expression, upregulated BAX and repressed cell apoptosis. Here, we show that PCAF can directly acetylate cytoplasmic GLI1 protein at lysine 518, preventing its nuclear translocation and promoter occupancy, and consequently suppressing Hedgehog (Hh) signaling in HCC.
23981651	Hepatocellular Carcinoma	downstream	AKT signaling	Negative regulation	PCAF overexpression induced cell apoptosis and growth arrest with increased Histone H4 acetylation and inactivation of AKT signaling in Huh7 and HepG2 cells.
23095762	Pancreatic Carcinoma	upstream	miR-17-5p	Negative regulation	Expression of PCAF in PCa cells was associated with the downregulation of miR-17-5p.
23095762	Pancreatic Carcinoma	downstream	AR	Positive regulation	Upregulation of PCAF promoted AR transcriptional activation and cell growth in cultured PCa cells.
20026908	Gastric Carcinoma; intestinal type Gastric Carcinoma	partner	p53	Correlation	A reduced PCAF protein expression correlated significantly with a mutant type p53 protein expression (P<0.01).
28418886	Colon Carcinoma	downstream	CXCL12	Negative regulation	Thus, reduced PCAF expression may participate to CXCL12 promoter hypoacetylation and its subsequent loss of expression.
28053092	acute promyelocyticLeukemia	upstream	ATRA	Positive regulation	These results strongly support our hypothesis that PCAF is induced and activated by ATRA, and the subsequent acetylation of PCAF substrates promotes granulocytic differentiation in leukemia cells.
28053092	acute promyelocyticLeukemia	downstream	CD11b	Positive regulation	Conversely, the overexpression of PCAF induced the expression of the granulocytic differentiation marker CD11b at the mRNA level.
28042499	Gastric Carcinoma	partner	p16; CDK4	Collaboration	Together these results suggest that PCAF acts as a GC suppressor through a novel PCAF-p16-CDK4 axis.
27453350	Alveolar rhabdomyosarcoma	downstream	PAX3-FOXO1	Positive regulation	Interestingly, in fusion-positive ARMS cell lines, P/CAF acetylates and stabilizes PAX3-FOXO1 rather than MyoD, a master regulator of muscle differentiation.