CR2Cancer

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF01853 MOZ/SAS family
PF11717 RNA binding activity-knot of a chromodomain

Function

Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification write	Histone acetylation	H2A, H3, H4	H2Aac, H3ac, H4ac	10786633

> Gene Ontology [ TOP ]
Biological Process	GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006914 autophagy GO:0010506 regulation of autophagy GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0030099 myeloid cell differentiation GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043981 histone H4-K5 acetylation GO:0043982 histone H4-K8 acetylation GO:0043984 histone H4-K16 acetylation
Molecular Function	GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0010485 H4 histone acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0034212 peptide N-acetyltransferase activity GO:0035064 methylated histone binding GO:0042393 histone binding GO:0043995 histone acetyltransferase activity (H4-K5 specific) GO:0043996 histone acetyltransferase activity (H4-K8 specific) GO:0046972 histone acetyltransferase activity (H4-K16 specific) GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0031248 protein acetyltransferase complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0044665 MLL1/2 complex GO:0071339 MLL1 complex GO:0072487 MSL complex GO:0098687 chromosomal region GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM4553411	c.58G>A	p.E20K	Substitution - Missense	Skin
COSM4694080	c.1265T>C	p.V422A	Substitution - Missense	Large_intestine
COSM211009	c.269A>G	p.Y90C	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5513190	c.1303C>A	p.P435T	Substitution - Missense	Biliary_tract
COSM3888426	c.255C>T	p.G85G	Substitution - coding silent	Skin
COSM5971772	c.1040G>A	p.G347D	Substitution - Missense	Upper_aerodigestive_tract
COSM5715563	c.13G>A	p.G5R	Substitution - Missense	Skin
COSM435159	c.254G>A	p.G85D	Substitution - Missense	Breast
COSM1216520	c.407G>A	p.R136H	Substitution - Missense	Large_intestine
COSM3509072	c.844C>T	p.P282S	Substitution - Missense	Skin
COSM185219	c.292C>T	p.R98W	Substitution - Missense	Prostate
COSM1640467	c.295C>T	p.R99W	Substitution - Missense	Liver
COSM5715563	c.13G>A	p.G5R	Substitution - Missense	Skin
COSM185219	c.292C>T	p.R98W	Substitution - Missense	Large_intestine
COSM5724242	c.715G>A	p.E239K	Substitution - Missense	Skin
COSM703191	c.913G>T	p.E305*	Substitution - Nonsense	Lung
COSM254833	c.419G>A	p.R140H	Substitution - Missense	Urinary_tract
COSM1258616	c.1049A>C	p.E350A	Substitution - Missense	Pancreas
COSM1478831	c.1019C>T	p.S340F	Substitution - Missense	Breast
COSM330329	c.634T>G	p.Y212D	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5028130	c.1130G>A	p.R377Q	Substitution - Missense	Breast
COSM1609223	c.997A>G	p.I333V	Substitution - Missense	Liver
COSM6002012	c.296G>A	p.R99Q	Substitution - Missense	Prostate
COSM1749574	c.781C>T	p.Q261*	Substitution - Nonsense	Urinary_tract
COSM970125	c.418C>T	p.R140C	Substitution - Missense	Salivary_gland
COSM1719608	c.1143C>T	p.S381S	Substitution - coding silent	Skin
COSM1258616	c.1049A>C	p.E350A	Substitution - Missense	Pancreas
COSM5000084	c.452A>G	p.H151R	Substitution - Missense	Pancreas
COSM471663	c.1038C>T	p.V346V	Substitution - coding silent	Kidney
COSM2917612	c.810C>T	p.F270F	Substitution - coding silent	Skin
COSM5886923	c.478G>A	p.D160N	Substitution - Missense	Skin
COSM970129	c.598G>A	p.D200N	Substitution - Missense	Endometrium
COSM1640469	c.1046C>A	p.P349Q	Substitution - Missense	Stomach
COSM4809262	c.415A>T	p.T139S	Substitution - Missense	Pancreas
COSM1662352	c.1106T>A	p.L369Q	Substitution - Missense	Kidney
COSM3707019	c.681+1G>A	p.?	Unknown	Liver
COSM5499256	c.703delC	p.E239fs*50	Deletion - Frameshift	Biliary_tract
COSM1493625	c.879G>A	p.R293R	Substitution - coding silent	Large_intestine
COSM254833	c.419G>A	p.R140H	Substitution - Missense	Upper_aerodigestive_tract
COSM5446223	c.666_667insCA	p.Y223fs*67	Insertion - Frameshift	Thyroid
COSM1377597	c.961delC	p.Y323fs*48	Deletion - Frameshift	Large_intestine
COSM970135	c.915G>A	p.E305E	Substitution - coding silent	Endometrium
COSM254833	c.419G>A	p.R140H	Substitution - Missense	Urinary_tract
COSM5517475	c.442G>A	p.E148K	Substitution - Missense	Biliary_tract
COSM1578501	c.1110_1111AG>GC	p.E371Q	Substitution - Missense	Lung
COSM1258616	c.1049A>C	p.E350A	Substitution - Missense	Pancreas
COSM970127	c.507G>T	p.E169D	Substitution - Missense	Large_intestine
COSM1609223	c.997A>G	p.I333V	Substitution - Missense	Liver
COSM254833	c.419G>A	p.R140H	Substitution - Missense	Pancreas
COSM6002326	c.1151A>T	p.D384V	Substitution - Missense	Prostate
COSM5517473	c.14G>C	p.G5A	Substitution - Missense	Biliary_tract
COSM1640468	c.517-5T>C	p.?	Unknown	Stomach
COSM4060394	c.562G>A	p.E188K	Substitution - Missense	Stomach
COSM1258615	c.165delG	p.E56fs*20	Deletion - Frameshift	Oesophagus
COSM1478830	c.670C>G	p.R224G	Substitution - Missense	Breast
COSM3509074	c.1039G>A	p.G347S	Substitution - Missense	Skin
COSM1640467	c.295C>T	p.R99W	Substitution - Missense	Stomach
COSM1258617	c.222A>C	p.E74D	Substitution - Missense	Oesophagus
COSM4060392	c.554G>A	p.G185E	Substitution - Missense	Stomach
COSM1749574	c.781C>T	p.Q261*	Substitution - Nonsense	Urinary_tract
COSM5715563	c.13G>A	p.G5R	Substitution - Missense	Skin
COSM75540	c.256C>G	p.R86G	Substitution - Missense	Ovary
COSM970133	c.812T>A	p.L271Q	Substitution - Missense	Endometrium
COSM1258616	c.1049A>C	p.E350A	Substitution - Missense	Stomach
COSM4060388	c.430C>T	p.R144C	Substitution - Missense	Stomach
COSM5363241	c.1339delC	p.K449fs*>10	Deletion - Frameshift	Large_intestine
COSM245909	c.293G>A	p.R98Q	Substitution - Missense	Prostate
COSM703190	c.1321G>C	p.V441L	Substitution - Missense	Lung
COSM3888428	c.901T>C	p.Y301H	Substitution - Missense	Skin
COSM185219	c.292C>T	p.R98W	Substitution - Missense	Skin
COSM970125	c.418C>T	p.R140C	Substitution - Missense	Upper_aerodigestive_tract
COSM1719608	c.1143C>T	p.S381S	Substitution - coding silent	Skin
COSM1216519	c.1217T>C	p.V406A	Substitution - Missense	Large_intestine
COSM1258616	c.1049A>C	p.E350A	Substitution - Missense	Pancreas
COSM1377596	c.702_703insC	p.G237fs*16	Insertion - Frameshift	Autonomic_ganglia
COSM4129016	c.1056A>G	p.P352P	Substitution - coding silent	Thyroid
COSM2917606	c.612G>T	p.Q204H	Substitution - Missense	Large_intestine
COSM185219	c.292C>T	p.R98W	Substitution - Missense	Stomach
COSM4826166	c.868G>C	p.E290Q	Substitution - Missense	Cervix
COSM5724242	c.715G>A	p.E239K	Substitution - Missense	Skin
COSM2917607	c.671G>A	p.R224H	Substitution - Missense	Large_intestine
COSM4694077	c.881_882insG	p.A296fs*43	Insertion - Frameshift	Large_intestine
COSM970131	c.607A>G	p.K203E	Substitution - Missense	Endometrium
COSM3707019	c.681+1G>A	p.?	Unknown	Liver
COSM1377594	c.150G>A	p.E50E	Substitution - coding silent	Large_intestine
COSM185219	c.292C>T	p.R98W	Substitution - Missense	Stomach
COSM1377597	c.961delC	p.Y323fs*48	Deletion - Frameshift	Large_intestine
COSM3509076	c.1048G>A	p.E350K	Substitution - Missense	Skin
COSM1377596	c.702_703insC	p.G237fs*16	Insertion - Frameshift	Large_intestine
COSM5015372	c.788T>C	p.L263P	Substitution - Missense	Kidney
COSM1172326	c.827_828delTG	p.Y277fs*2	Deletion - Frameshift	Oesophagus
COSM3772201	c.760A>G	p.K254E	Substitution - Missense	Pancreas
COSM4060384	c.168G>C	p.E56D	Substitution - Missense	Stomach
COSM254833	c.419G>A	p.R140H	Substitution - Missense	Central_nervous_system
COSM1377595	c.487A>G	p.T163A	Substitution - Missense	Large_intestine
COSM2917607	c.671G>A	p.R224H	Substitution - Missense	Oesophagus
COSM254833	c.419G>A	p.R140H	Substitution - Missense	Stomach
COSM1236470	c.666C>A	p.S222R	Substitution - Missense	Autonomic_ganglia
COSM4508137	c.766C>T	p.H256Y	Substitution - Missense	Skin
COSM970127	c.507G>T	p.E169D	Substitution - Missense	Endometrium
COSM5218217	c.914_916delAGA	p.K306delK	Deletion - In frame	Breast
COSM124648	c.811C>G	p.L271V	Substitution - Missense	Upper_aerodigestive_tract
COSM1640467	c.295C>T	p.R99W	Substitution - Missense	Liver
COSM703195	c.259G>C	p.E87Q	Substitution - Missense	Lung
COSM4425956	c.390C>T	p.L130L	Substitution - coding silent	Oesophagus
COSM5684592	c.100A>C	p.T34P	Substitution - Missense	Soft_tissue
COSM4060396	c.1272G>A	p.E424E	Substitution - coding silent	Stomach
COSM1493625	c.879G>A	p.R293R	Substitution - coding silent	Kidney
COSM1719608	c.1143C>T	p.S381S	Substitution - coding silent	Skin
COSM3817863	c.1369A>G	p.K457E	Substitution - Missense	Breast
COSM1216518	c.20C>A	p.A7D	Substitution - Missense	Large_intestine
COSM4694075	c.741C>T	p.S247S	Substitution - coding silent	Large_intestine
COSM4694073	c.508C>G	p.H170D	Substitution - Missense	Large_intestine
COSM1301912	c.1077C>T	p.L359L	Substitution - coding silent	Urinary_tract
COSM254833	c.419G>A	p.R140H	Substitution - Missense	Central_nervous_system
COSM4975315	c.220G>A	p.E74K	Substitution - Missense	Oesophagus
COSM5499258	c.798G>T	p.L266L	Substitution - coding silent	Biliary_tract
COSM703193	c.325C>T	p.L109L	Substitution - coding silent	Lung
COSM5479106	c.836A>G	p.D279G	Substitution - Missense	Large_intestine
COSM970125	c.418C>T	p.R140C	Substitution - Missense	Endometrium
COSM5016514	c.985delG	p.K330fs*41	Deletion - Frameshift	Kidney
COSM4780477	c.642C>T	p.L214L	Substitution - coding silent	Liver
COSM5715563	c.13G>A	p.G5R	Substitution - Missense	Skin
COSM6002326	c.1151A>T	p.D384V	Substitution - Missense	Prostate
COSM1324484	c.288T>A	p.F96L	Substitution - Missense	Ovary
COSM1609222	c.132G>T	p.P44P	Substitution - coding silent	Liver
COSM5013006	c.109T>A	p.S37T	Substitution - Missense	Kidney
COSM4060390	c.431G>A	p.R144H	Substitution - Missense	Stomach
COSM4060386	c.406C>T	p.R136C	Substitution - Missense	Stomach
COSM4807461	c.450C>A	p.N150K	Substitution - Missense	Pancreas
COSM185219	c.292C>T	p.R98W	Substitution - Missense	Stomach
COSM1640467	c.295C>T	p.R99W	Substitution - Missense	Large_intestine
COSM4752101	c.749A>G	p.E250G	Substitution - Missense	Stomach
COSM703192	c.831C>T	p.Y277Y	Substitution - coding silent	Lung
COSM254833	c.419G>A	p.R140H	Substitution - Missense	Urinary_tract
COSM5724242	c.715G>A	p.E239K	Substitution - Missense	Skin
COSM5724242	c.715G>A	p.E239K	Substitution - Missense	Skin
COSM4436383	c.1278C>T	p.L426L	Substitution - coding silent	Oesophagus
COSM703194	c.322C>T	p.R108W	Substitution - Missense	Lung
COSM3370411	c.1126T>C	p.F376L	Substitution - Missense	Thyroid

> Text Mining based Variations [ TOP ]
There is no record for KAT8.

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9H7Z6	37	S	Phosphoserine	-	No	None detected
Q9H7Z6	42	S	Phosphoserine	-	No	None detected
Q9H7Z6	113	K	N6-acetyllysine	-	No	None detected
Q9H7Z6	274	K	N6-acetyllysine	autocatalysis	No	None detected
Q9H7Z6	348	S	Phosphoserine	-	No	None detected

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.749	4.841	0.102	0.504	NS
BRCA	Breast invasive carcinoma	112	1100	4.838	5.053	0.254	6.01e-05	NS
CESC	Cervical and endocervical cancers	3	306	5.76	5.079	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.906	5.005	0.124	0.0885	NS
ESCA	Esophageal carcinoma	11	185	4.715	4.551	-0.114	0.565	NS
GBM	Glioblastoma multiforme	5	166	5.499	5.315	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.333	4.385	-0.016	0.871	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.496	4.977	0.479	3.6e-15	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.727	5.622	0.794	2.71e-13	Over
LAML	Acute Myeloid Leukemia	0	173	NA	5.558	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	5.71	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.397	4.312	-0.025	0.795	NS
LUAD	Lung adenocarcinoma	59	517	4.948	5.01	0.076	0.322	NS
LUSC	Lung squamous cell carcinoma	51	501	4.968	4.718	-0.215	0.00523	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.764	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.22	5.065	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.572	5.502	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	5.007	5.105	0.081	0.203	NS
READ	Rectum adenocarcinoma	10	167	4.749	5.089	0.356	0.0319	NS
SARC	Sarcoma	2	263	4.959	5.183	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	4.687	4.692	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.097	4.829	-0.191	0.0357	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.001	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.476	5.563	0.119	0.046	NS
THYM	Thymoma	2	120	5.81	6.331	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	5.684	5.397	-0.282	0.0086	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	19.9
Adrenal gland	27
Appendix	22.6
Bone marrow	19.3
Breast	26.3
Cerebral cortex	33.7
Cervix, uterine	38.7
Colon	19
Duodenum	15.9
Endometrium	41.8
Epididymis	54.8
Esophagus	17.7
Fallopian tube	54
Gallbladder	22.2
Heart muscle	22.9
Kidney	16.7
Liver	9.6
Lung	31.2
Lymph node	27.1
Ovary	61.5
Pancreas	4.6
Parathyroid gland	56.7
Placenta	28
Prostate	28.8
Rectum	18.7
Salivary gland	14.7
Seminal vesicle	31.8
Skeletal muscle	9.8
Skin	26.2
Small intestine	17.5
Smooth muscle	36.5
Spleen	33.6
Stomach	12.7
Testis	40.5
Thyroid gland	41.9
Tonsil	21.6
Urinary bladder	19.9

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27715462	Underexpression	Gastric Carcinoma	Reduced hMOF activity was detected in GC tissues, which could be restored by CAP both in vivo and in vitro.
26032517	Overexpression	Oral Tongue Squamous Cell Carcinoma	Real time PCR and western blot analysis were applied, and it was found that hMOF level was up-regulated in human OTSCC
25873202	Underexpression	Gastric Carcinoma	Statistical analysis of the qRT-PCR data revealed that a significant reduction (>2-fold decreased) of hMOF expression in gastric cancer tissues in 81% (42/52) of patients.
25483274	Underexpression	Ovarian Carcinoma	Compared with normal ovarian tissues, hMOF mRNA and protein expression was significantly decreased in ovarian epithelial cancer tissues.
25181338	Underexpression	Hepatocellular Carcinoma	Here we find that the expression of hMOF is significantly down-regulated in human hepatocellular carcinoma and cell lines.
24571482	Overexpression	Non-Small Cell Lung Cancer	hMOF was overexpressed in human NSCLC tissues and was associated with large tumour size, advanced disease stage and metastasis, and with poor prognosis.
24452485	Underexpression	Colorectal Carcinoma; Gastric Carcinoma; Renal Cell Carcinoma	Statistical analysis of qPCR data revealed a significant reduction (>2-fold decrease) of hMOF gene expression in CRC, 57% (25/44), 94% (15/16) in gastric cancer and 74% (35/47) in RCC tissues of the patients.
24137335	Underexpression	Ovarian Carcinoma	A PCR analysis of mRNA expression in 47 samples revealed a downregulation of hMOF mRNA in 81% of patients, whereas only 13% of patients demonstrated upregulation.
23628702	Overexpression	Non-Small Cell Lung Cancer	In this study, hMOF was found to be more frequently highly expressed in non-small cell lung cancer (NSCLC) than corresponding normal tissues (P < 0.001).
23394073	Underexpression	Renal Cell Carcinoma	RT-PCR results indicate that hMOF gene expression levels frequently downregulated in 90.5% of patients (19/21) with RCC.
18058815	Underexpression	Breast Carcinoma; Medulloblastoma	In contrast to nontransformed control tissues, significant fractions of both primary breast carcinomas and medulloblastomas showed markedly reduced hMOF mRNA and protein expression. For medulloblastoma, downregulation of hMOF protein expression was associated with lower survival rates identifying hMOF as an independent prognostic marker for clinical outcome in univariate as well as multivariate analyses.
27715462	Underexpression	Gastric Carcinoma	Reduced hMOF activity was detected in GC tissues, which could be restored by CAP both in vivo and in vitro.

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.552	1.34e-33	23.5	54.2	22.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.617	5.73e-114	8.5	40.9	50.6	Gain
CESC	Cervical and endocervical cancers	292	0.46	1.08e-16	12.3	73.6	14	Neutral
COAD	Colon adenocarcinoma	449	0.48	3.22e-27	4.9	67.7	27.4	Neutral
ESCA	Esophageal carcinoma	183	0.619	1.03e-20	24.6	50.8	24.6	Neutral
GBM	Glioblastoma multiforme	147	0.415	1.79e-07	15.6	78.9	5.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.388	5.96e-20	10.7	67.5	21.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.264	7.53e-10	2.3	77.1	20.6	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.501	1.11e-19	1	45.5	53.5	Gain
LAML	Acute Myeloid Leukemia	166	0.283	0.000218	2.4	97.6	0	Neutral
LGG	Brain Lower Grade Glioma	513	0.269	6.38e-10	3.7	93	3.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.515	4.41e-26	24.7	64.6	10.7	Neutral
LUAD	Lung adenocarcinoma	512	0.576	1.57e-46	16.2	51.6	32.2	Neutral
LUSC	Lung squamous cell carcinoma	498	0.61	4.81e-52	25.7	50.4	23.9	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.673	6.79e-41	36.3	45.7	18	Loss
PAAD	Pancreatic adenocarcinoma	177	0.074	0.326	4.5	81.9	13.6	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.41	6.24e-08	4.9	91.4	3.7	Neutral
PRAD	Prostate adenocarcinoma	491	0.23	2.72e-07	6.5	86.8	6.7	Neutral
READ	Rectum adenocarcinoma	164	0.596	4.07e-17	4.9	68.3	26.8	Neutral
SARC	Sarcoma	255	0.506	5.61e-18	23.5	56.1	20.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.442	6.09e-19	16.3	66.5	17.2	Neutral
STAD	Stomach adenocarcinoma	413	0.547	1.44e-33	17.4	64.6	17.9	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.475	8.14e-10	28	60	12	Neutral
THCA	Thyroid carcinoma	497	0.173	0.000108	0.2	97.2	2.6	Neutral
THYM	Thymoma	119	0.111	0.231	2.5	94.1	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.491	5.43e-34	11	77.5	11.5	Neutral

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.216	7.33e-06	17	408	0.005	0.00135	NS/NA
BRCA	Breast invasive carcinoma	-0.172	3.44e-07	83	785	-0.007	0.00151	NS/NA
CESC	Cervical and endocervical cancers	-0.126	0.0266	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.277	6.11e-07	19	297	-0.01	0.495	NS/NA
ESCA	Esophageal carcinoma	-0.152	0.0343	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.35	0.00445	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.174	4.8e-05	20	522	-0.034	0.701	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.112	0.0374	24	319	0.003	0.0153	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.311	4.93e-08	23	275	-0.033	0.348	NS/NA
LAML	Acute Myeloid Leukemia	-0.089	0.248	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.136	0.00178	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.295	1.11e-09	41	373	0	0.899	NS/NA
LUAD	Lung adenocarcinoma	-0.208	5.05e-06	21	456	-0.026	0.0776	NS/NA
LUSC	Lung squamous cell carcinoma	-0.304	2.04e-09	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.833	0.00827	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.158	0.0325	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.071	0.333	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.284	3.2e-11	35	498	-0.041	1.05e-07	NS/NA
READ	Rectum adenocarcinoma	-0.384	8.38e-05	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.239	9.71e-05	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.198	1.48e-05	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.249	1.3e-06	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.378	1.35e-06	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.15	0.000379	50	509	0	0.416	NS/NA
THYM	Thymoma	-0.07	0.445	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.179	0.000107	34	431	-0.001	0.917	NS/NA

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.849	NS	24476821
BRCA	Breast invasive carcinoma	521	0.000202	Significant	23000897
COAD	Colon adenocarcinoma	149	0.000129	Significant	22810696
GBM	Glioblastoma multiforme	157	1.98e-05	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	4.22e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0413	Significant	26536169
LGG	Brain Lower Grade Glioma	513	3.07e-13	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0224	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00184	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.00135	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0921	NS	26544944
READ	Rectum adenocarcinoma	67	0.000597	Significant	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0932	NS	26091043
STAD	Stomach adenocarcinoma	277	0.00188	Significant	25079317
THCA	Thyroid carcinoma	391	0.238	NS	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.00156	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.882	0.555	NS
BRCA	Breast invasive carcinoma	1079	0.968	0.892	NS
CESC	Cervical and endocervical cancers	291	0.647	0.157	NS
COAD	Colon adenocarcinoma	439	1.821	0.0474	Shorter
ESCA	Esophageal carcinoma	184	0.789	0.479	NS
GBM	Glioblastoma multiforme	158	0.719	0.216	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.845	0.388	NS
KIRC	Kidney renal clear cell carcinoma	531	1.678	0.0119	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	0.883	0.776	NS
LAML	Acute Myeloid Leukemia	149	1.386	0.295	NS
LGG	Brain Lower Grade Glioma	511	0.395	0.000415	Longer
LIHC	Liver hepatocellular carcinoma	365	0.732	0.219	NS
LUAD	Lung adenocarcinoma	502	0.827	0.361	NS
LUSC	Lung squamous cell carcinoma	494	1.022	0.914	NS
OV	Ovarian serous cystadenocarcinoma	303	0.89	0.579	NS
PAAD	Pancreatic adenocarcinoma	177	0.604	0.0852	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.0889	NS
PRAD	Prostate adenocarcinoma	497	602289461.37	0.0813	NS
READ	Rectum adenocarcinoma	159	1.522	0.377	NS
SARC	Sarcoma	259	0.809	0.462	NS
SKCM	Skin Cutaneous Melanoma	459	1.056	0.775	NS
STAD	Stomach adenocarcinoma	388	0.778	0.256	NS
TGCT	Testicular Germ Cell Tumors	134	1	1	NS
THCA	Thyroid carcinoma	500	0.401	0.258	NS
THYM	Thymoma	119	0.573	0.648	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.785	0.441	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.011	0.829	NS
BRCA	Breast invasive carcinoma	1071	-0.029	0.338	NS
CESC	Cervical and endocervical cancers	167	-0.038	0.624	NS
COAD	Colon adenocarcinoma	445	0.216	4.25e-06	Higher
ESCA	Esophageal carcinoma	162	-0.051	0.516	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.115	0.0153	Higher
KIRC	Kidney renal clear cell carcinoma	531	0.096	0.0275	Higher
KIRP	Kidney renal papillary cell carcinoma	260	-0.026	0.671	NS
LIHC	Liver hepatocellular carcinoma	347	0.001	0.982	NS
LUAD	Lung adenocarcinoma	507	-0.134	0.00244	Lower
LUSC	Lung squamous cell carcinoma	497	0.072	0.107	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.008	0.892	NS
PAAD	Pancreatic adenocarcinoma	176	-0.079	0.297	NS
READ	Rectum adenocarcinoma	156	0.057	0.479	NS
SKCM	Skin Cutaneous Melanoma	410	-0.107	0.0301	Lower
STAD	Stomach adenocarcinoma	392	-0.024	0.629	NS
TGCT	Testicular Germ Cell Tumors	81	0.166	0.139	NS
THCA	Thyroid carcinoma	499	0.076	0.091	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.048	0.284	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.041	0.497	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.156	0.000486	Higher
KIRC	Kidney renal clear cell carcinoma	525	0.081	0.0646	NS
LGG	Brain Lower Grade Glioma	514	-0.144	0.00107	Lower
LIHC	Liver hepatocellular carcinoma	366	-0.113	0.0307	Lower
OV	Ovarian serous cystadenocarcinoma	296	-0.032	0.581	NS
PAAD	Pancreatic adenocarcinoma	176	-0.085	0.262	NS
STAD	Stomach adenocarcinoma	406	-0.017	0.727	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.01	0.825	NS

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KAT8.

Summary
Symbol	KAT8
Name	lysine acetyltransferase 8
Aliases	MOF; FLJ14040; hMOF; ZC2HC8; MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein ......
Location	16p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]
There is no record for KAT8.

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26032517	Oral Tongue Squamous Cell Carcinoma	upstream	EZH2	positive regulation	Moreover, we have demonstrated that EZH2 was critically essential for function of hMOF in human OTSCC.
25181338	Hepatocellular Carcinoma	downstream	SIRT6	regulation	Mechanically, we show that hMOF regulates the expression of SIRT6 and its downstream genes.
24571482	Non-Small Cell Lung Cancer	partner	Nrf2 downstream genes	Positive correlation	hMOF levels were positively correlated with Nrf2-downstream genes.
24137335	Ovarian Carcinoma	downstream	HCP5	positive regulation	Furthermore, the expression of hMOF-regulated human leukocyte antigen (HLA) complex 5, (HCP5), was also found to be downregulated in >87% of patients with a decrease in hMOF. hMOF and its regulated gene, HCP5, are frequently downregulated in human ovarian cancer, suggesting that hMOF may be involved in the pathogenesis of the disease.
23628702	Non-Small Cell Lung Cancer	downstream	Skp2	regulation	Moreover, hMOF promotes S phase entry via Skp2.
27715462	Gastric Carcinoma	downstream	CAP	Positive regulation	The results showed that CAP could significantly suppress cell growth, while altering histone acetylation in GC cell lines. Further studies found that hMOF, a major histone acetyltranferase for H4K16, is central to CAP-induced epigenetic changes. Reduced hMOF activity was detected in GC tissues, which could be restored by CAP both in vivo and in vitro.