CR2Cancer

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF02373 JmjC domain
PF02375 jmjN domain

Function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K9me3	H3K9me1, H3K9me2	16603238

> Gene Ontology [ TOP ]
Biological Process	GO:0006482 protein demethylation GO:0008214 protein dealkylation GO:0016570 histone modification GO:0016577 histone demethylation GO:0070988 demethylation
Molecular Function	GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0051213 dioxygenase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-3214842: HDMs demethylate histones R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM5438160	c.528C>A	p.Y176*	Substitution - Nonsense	Oesophagus
COSM2755254	c.1652T>C	p.F551S	Substitution - Missense	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM999500	c.153G>A	p.P51P	Substitution - coding silent	Endometrium
COSM4080288	c.665G>A	p.R222Q	Substitution - Missense	Stomach
COSM4080439	c.961T>C	p.F321L	Substitution - Missense	Stomach
COSM27208	c.2221G>A	p.E741K	Substitution - Missense	Lung
COSM999837	c.2324G>A	p.R775H	Substitution - Missense	Endometrium
COSM1394661	c.2889T>C	p.P963P	Substitution - coding silent	Oesophagus
COSM999798	c.1302C>T	p.A434A	Substitution - coding silent	Endometrium
COSM1211737	c.1046C>T	p.A349V	Substitution - Missense	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM5149841	c.2679C>T	p.D893D	Substitution - coding silent	Large_intestine
COSM4817865	c.1255G>A	p.E419K	Substitution - Missense	Skin
COSM2753934	c.490G>A	p.E164K	Substitution - Missense	Large_intestine
COSM1394649	c.1903G>A	p.E635K	Substitution - Missense	Large_intestine
COSM1612642	c.1656G>T	p.E552D	Substitution - Missense	Liver
COSM5707146	c.2627C>T	p.T876M	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1394613	c.1059C>A	p.P353P	Substitution - coding silent	Large_intestine
COSM4285824	c.2164C>T	p.Q722*	Substitution - Nonsense	Oesophagus
COSM4644238	c.1130G>A	p.R377Q	Substitution - Missense	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4833720	c.584T>A	p.L195Q	Substitution - Missense	Cervix
COSM440070	c.1867C>A	p.P623T	Substitution - Missense	Breast
COSM3362964	c.774C>A	p.F258L	Substitution - Missense	Kidney
COSM4428820	c.3009C>T	p.S1003S	Substitution - coding silent	Oesophagus
COSM3713023	c.1616C>A	p.A539D	Substitution - Missense	Upper_aerodigestive_tract
COSM3713023	c.1616C>A	p.A539D	Substitution - Missense	Upper_aerodigestive_tract
COSM6003792	c.2558T>C	p.V853A	Substitution - Missense	Prostate
COSM4632237	c.3212A>T	p.D1071V	Substitution - Missense	Large_intestine
COSM3537409	c.2856C>T	p.F952F	Substitution - coding silent	Upper_aerodigestive_tract
COSM1255494	c.240G>A	p.S80S	Substitution - coding silent	Stomach
COSM3389227	c.754A>T	p.K252*	Substitution - Nonsense	Pancreas
COSM4468194	c.1530C>T	p.P510P	Substitution - coding silent	Skin
COSM4640243	c.666G>A	p.R222R	Substitution - coding silent	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM3423014	c.999G>T	p.W333C	Substitution - Missense	Large_intestine
COSM5929899	c.1571C>T	p.P524L	Substitution - Missense	Skin
COSM4644239	c.2806C>A	p.R936S	Substitution - Missense	Large_intestine
COSM1177793	c.2138C>T	p.P713L	Substitution - Missense	Endometrium
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM141536	c.3170C>A	p.A1057D	Substitution - Missense	Upper_aerodigestive_tract
COSM4694970	c.2826C>T	p.A942A	Substitution - coding silent	Large_intestine
COSM5134294	c.1508C>T	p.P503L	Substitution - Missense	Large_intestine
COSM5574703	c.766A>T	p.I256F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1211740	c.877G>A	p.A293T	Substitution - Missense	Large_intestine
COSM4406745	c.2484C>T	p.R828R	Substitution - coding silent	Pancreas
COSM3835474	c.2248G>A	p.G750S	Substitution - Missense	Breast
COSM1325200	c.192C>T	p.D64D	Substitution - coding silent	Ovary
COSM5390453	c.2344G>A	p.G782S	Substitution - Missense	Skin
COSM4439744	c.2530C>T	p.P844S	Substitution - Missense	Oesophagus
COSM5365559	c.1835G>A	p.R612H	Substitution - Missense	Large_intestine
COSM4653199	c.2674C>T	p.P892S	Substitution - Missense	Large_intestine
COSM5183048	c.1673G>A	p.G558D	Substitution - Missense	Large_intestine
COSM5718457	c.2413G>A	p.G805S	Substitution - Missense	Skin
COSM237597	c.2736+7G>A	p.?	Unknown	Prostate
COSM3672990	c.2631C>A	p.S877S	Substitution - coding silent	Prostate
COSM5695075	c.2040G>T	p.T680T	Substitution - coding silent	Soft_tissue
COSM3757070	c.1080A>G	p.A360A	Substitution - coding silent	Large_intestine
COSM5165314	c.1528delC	p.P511fs*8	Deletion - Frameshift	Large_intestine
COSM3537409	c.2856C>T	p.F952F	Substitution - coding silent	Skin
COSM999864	c.2661C>T	p.G887G	Substitution - coding silent	Large_intestine
COSM5105006	c.3220C>T	p.R1074W	Substitution - Missense	Large_intestine
COSM713260	c.1625A>T	p.Q542L	Substitution - Missense	Lung
COSM4817865	c.1255G>A	p.E419K	Substitution - Missense	Cervix
COSM5911021	c.675C>T	p.I225I	Substitution - coding silent	Skin
COSM4854348	c.2058C>G	p.I686M	Substitution - Missense	Cervix
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4080205	c.111G>A	p.S37S	Substitution - coding silent	Stomach
COSM312116	c.1991C>T	p.A664V	Substitution - Missense	Lung
COSM1612590	c.73T>C	p.F25L	Substitution - Missense	Liver
COSM5783486	c.407A>G	p.D136G	Substitution - Missense	Breast
COSM4080504	c.1463C>T	p.P488L	Substitution - Missense	Stomach
COSM1612642	c.1656G>T	p.E552D	Substitution - Missense	Liver
COSM4817865	c.1255G>A	p.E419K	Substitution - Missense	Skin
COSM5454765	c.1196C>T	p.A399V	Substitution - Missense	Large_intestine
COSM5390449	c.1840C>T	p.P614S	Substitution - Missense	Skin
COSM131228	c.254A>G	p.Q85R	Substitution - Missense	Liver
COSM5677764	c.1120C>G	p.H374D	Substitution - Missense	Soft_tissue
COSM999839	c.2374G>A	p.A792T	Substitution - Missense	Endometrium
COSM1394650	c.2208C>T	p.G736G	Substitution - coding silent	Large_intestine
COSM1750993	c.2527A>G	p.I843V	Substitution - Missense	Urinary_tract
COSM713327	c.768C>T	p.I256I	Substitution - coding silent	Lung
COSM1394641	c.1712C>T	p.T571M	Substitution - Missense	Large_intestine
COSM1564352	c.1322G>A	p.G441E	Substitution - Missense	Large_intestine
COSM5555469	c.1216G>T	p.G406C	Substitution - Missense	Prostate
COSM5973104	c.2566C>T	p.R856W	Substitution - Missense	Upper_aerodigestive_tract
COSM336571	c.1036C>T	p.R346W	Substitution - Missense	Stomach
COSM4080443	c.1111C>T	p.R371C	Substitution - Missense	Stomach
COSM4979025	c.50C>T	p.T17M	Substitution - Missense	Oesophagus
COSM5452493	c.1149G>A	p.P383P	Substitution - coding silent	Large_intestine
COSM3835411	c.355G>T	p.E119*	Substitution - Nonsense	Breast
COSM1394650	c.2208C>T	p.G736G	Substitution - coding silent	Large_intestine
COSM1394661	c.2889T>C	p.P963P	Substitution - coding silent	Large_intestine
COSM4080260	c.571G>A	p.E191K	Substitution - Missense	Stomach
COSM2753750	c.349G>A	p.D117N	Substitution - Missense	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4694972	c.3172G>A	p.A1058T	Substitution - Missense	Large_intestine
COSM4080326	c.696G>A	p.S232S	Substitution - coding silent	Stomach
COSM4638252	c.3050C>T	p.T1017M	Substitution - Missense	Large_intestine
COSM5183046	c.152C>T	p.P51L	Substitution - Missense	Large_intestine
COSM5158971	c.3234C>T	p.Y1078Y	Substitution - coding silent	Large_intestine
COSM225064	c.1960C>T	p.P654S	Substitution - Missense	Skin
COSM4620755	c.1490T>C	p.M497T	Substitution - Missense	Large_intestine
COSM5670431	c.1343C>G	p.T448S	Substitution - Missense	Soft_tissue
COSM4080245	c.317+2T>C	p.?	Unknown	Stomach
COSM4080524	c.2652C>T	p.H884H	Substitution - coding silent	Stomach
COSM2753906	c.450C>T	p.N150N	Substitution - coding silent	Large_intestine
COSM3414093	c.2322C>T	p.I774I	Substitution - coding silent	Oesophagus
COSM3537026	c.264C>T	p.I88I	Substitution - coding silent	Skin
COSM1711633	c.2845G>A	p.E949K	Substitution - Missense	Skin
COSM4694957	c.79G>T	p.D27Y	Substitution - Missense	Large_intestine
COSM5343405	c.2027C>T	p.A676V	Substitution - Missense	Large_intestine
COSM3971188	c.1656G>A	p.E552E	Substitution - coding silent	Central_nervous_system
COSM999625	c.709G>A	p.A237T	Substitution - Missense	Endometrium
COSM5168831	c.365A>G	p.Y122C	Substitution - Missense	Large_intestine
COSM5517712	c.2934C>T	p.S978S	Substitution - coding silent	Biliary_tract
COSM4805868	c.2400C>G	p.C800W	Substitution - Missense	Liver
COSM999561	c.590G>A	p.S197N	Substitution - Missense	Endometrium
COSM2753932	c.485A>G	p.E162G	Substitution - Missense	Bone
COSM1711631	c.1172C>T	p.P391L	Substitution - Missense	Skin
COSM4749126	c.190G>A	p.D64N	Substitution - Missense	Stomach
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM713329	c.689G>T	p.G230V	Substitution - Missense	Lung
COSM5741365	c.1028A>G	p.D343G	Substitution - Missense	Small_intestine
COSM5888412	c.1514C>T	p.P505L	Substitution - Missense	Upper_aerodigestive_tract
COSM222362	c.1171C>T	p.P391S	Substitution - Missense	Skin
COSM999862	c.2556C>T	p.C852C	Substitution - coding silent	Endometrium
COSM1394611	c.988T>C	p.Y330H	Substitution - Missense	Large_intestine
COSM3835469	c.1492G>A	p.E498K	Substitution - Missense	Breast
COSM2755259	c.1728T>C	p.G576G	Substitution - coding silent	Large_intestine
COSM4422885	c.1154_1160delCCGAAGA	p.E386fs*14	Deletion - Frameshift	Kidney
COSM4817865	c.1255G>A	p.E419K	Substitution - Missense	Skin
COSM5390428	c.972C>T	p.I324I	Substitution - coding silent	Skin
COSM1177793	c.2138C>T	p.P713L	Substitution - Missense	Large_intestine
COSM5390348	c.144C>T	p.I48I	Substitution - coding silent	Skin
COSM3757070	c.1080A>G	p.A360A	Substitution - coding silent	Large_intestine
COSM4656909	c.1241C>T	p.P414L	Substitution - Missense	Large_intestine
COSM4694968	c.2573G>A	p.R858Q	Substitution - Missense	Large_intestine
COSM999796	c.1296G>A	p.R432R	Substitution - coding silent	Endometrium
COSM3537378	c.1956G>A	p.L652L	Substitution - coding silent	Skin
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM1325200	c.192C>T	p.D64D	Substitution - coding silent	Stomach
COSM1394639	c.1474C>A	p.P492T	Substitution - Missense	Large_intestine
COSM713257	c.1715G>T	p.G572V	Substitution - Missense	Lung
COSM4080258	c.449A>G	p.N150S	Substitution - Missense	Stomach
COSM3757070	c.1080A>G	p.A360A	Substitution - coding silent	Large_intestine
COSM4956379	c.1946C>T	p.P649L	Substitution - Missense	Liver
COSM999445	c.93C>T	p.Y31Y	Substitution - coding silent	Endometrium
COSM2755264	c.1848C>T	p.G616G	Substitution - coding silent	Skin
COSM999864	c.2661C>T	p.G887G	Substitution - coding silent	Endometrium
COSM1189781	c.1768C>T	p.R590W	Substitution - Missense	Lung
COSM4607729	c.1585C>A	p.L529M	Substitution - Missense	Adrenal_gland
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM999794	c.1125G>A	p.R375R	Substitution - coding silent	Endometrium
COSM4553755	c.5G>A	p.G2E	Substitution - Missense	Skin
COSM3770666	c.2598T>C	p.C866C	Substitution - coding silent	Soft_tissue
COSM5574703	c.766A>T	p.I256F	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM713247	c.1950C>T	p.D650D	Substitution - coding silent	Lung
COSM1711633	c.2845G>A	p.E949K	Substitution - Missense	Lung
COSM312117	c.2225C>A	p.P742Q	Substitution - Missense	Lung
COSM1637858	c.736A>G	p.I246V	Substitution - Missense	Bone
COSM5434978	c.2366C>T	p.A789V	Substitution - Missense	Oesophagus
COSM4080441	c.1019C>T	p.T340M	Substitution - Missense	Stomach
COSM5741367	c.3244G>A	p.V1082M	Substitution - Missense	Small_intestine
COSM1255492	c.874T>G	p.F292V	Substitution - Missense	Oesophagus
COSM1612596	c.537C>G	p.F179L	Substitution - Missense	Liver
COSM5421129	c.1747G>T	p.G583C	Substitution - Missense	Prostate
COSM4457771	c.1059C>T	p.P353P	Substitution - coding silent	Skin
COSM3757070	c.1080A>G	p.A360A	Substitution - coding silent	Large_intestine
COSM4694963	c.496G>A	p.G166S	Substitution - Missense	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4749135	c.1079C>T	p.A360V	Substitution - Missense	Stomach
COSM3537032	c.396C>T	p.I132I	Substitution - coding silent	Skin
COSM6003792	c.2558T>C	p.V853A	Substitution - Missense	Prostate
COSM4080513	c.1992G>A	p.A664A	Substitution - coding silent	Stomach
COSM3537077	c.558C>T	p.F186F	Substitution - coding silent	Skin
COSM5438691	c.642A>G	p.P214P	Substitution - coding silent	Oesophagus
COSM4956379	c.1946C>T	p.P649L	Substitution - Missense	Liver
COSM1394644	c.1832G>A	p.R611Q	Substitution - Missense	Large_intestine
COSM1564362	c.489C>T	p.R163R	Substitution - coding silent	Large_intestine
COSM3773106	c.195C>T	p.D65D	Substitution - coding silent	Pancreas
COSM3537363	c.1698C>T	p.S566S	Substitution - coding silent	Skin
COSM475057	c.161G>T	p.W54L	Substitution - Missense	Kidney
COSM5718457	c.2413G>A	p.G805S	Substitution - Missense	Skin
COSM213156	c.3223A>G	p.S1075G	Substitution - Missense	Breast
COSM5799171	c.1120C>T	p.H374Y	Substitution - Missense	Breast
COSM4805868	c.2400C>G	p.C800W	Substitution - Missense	Liver
COSM5471091	c.1116-9C>A	p.?	Unknown	Large_intestine
COSM1612616	c.1074G>T	p.W358C	Substitution - Missense	Liver
COSM5364725	c.1500delC	p.L502fs*17	Deletion - Frameshift	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4080514	c.2214G>A	p.E738E	Substitution - coding silent	Stomach
COSM4581339	c.1977G>A	p.Q659Q	Substitution - coding silent	Bone
COSM1750993	c.2527A>G	p.I843V	Substitution - Missense	Urinary_tract
COSM4421668	c.431A>G	p.D144G	Substitution - Missense	Pleura
COSM5718457	c.2413G>A	p.G805S	Substitution - Missense	Skin
COSM312114	c.60A>T	p.P20P	Substitution - coding silent	Soft_tissue
COSM3713024	c.1717C>A	p.P573T	Substitution - Missense	Upper_aerodigestive_tract
COSM5084972	c.1541C>A	p.P514H	Substitution - Missense	Large_intestine
COSM4460541	c.1170C>T	p.F390F	Substitution - coding silent	Skin
COSM5449319	c.677-6C>T	p.?	Unknown	Large_intestine
COSM3537379	c.2266C>T	p.P756S	Substitution - Missense	Skin
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM3378823	c.2957G>A	p.R986Q	Substitution - Missense	Pancreas
COSM713258	c.1626G>T	p.Q542H	Substitution - Missense	Lung
COSM1612596	c.537C>G	p.F179L	Substitution - Missense	Liver
COSM4132333	c.2334G>A	p.L778L	Substitution - coding silent	Thyroid
COSM5820923	c.2978A>T	p.Y993F	Substitution - Missense	Liver
COSM999505	c.210G>A	p.A70A	Substitution - coding silent	Endometrium
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM3990185	c.916C>A	p.Q306K	Substitution - Missense	Kidney
COSM4694965	c.1035G>A	p.T345T	Substitution - coding silent	Large_intestine
COSM4080525	c.2755G>A	p.V919M	Substitution - Missense	Stomach
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4694955	c.22G>A	p.A8T	Substitution - Missense	Large_intestine
COSM1394661	c.2889T>C	p.P963P	Substitution - coding silent	Large_intestine
COSM3713024	c.1717C>A	p.P573T	Substitution - Missense	Upper_aerodigestive_tract
COSM4891624	c.2046C>G	p.P682P	Substitution - coding silent	Upper_aerodigestive_tract
COSM999518	c.392C>T	p.P131L	Substitution - Missense	Endometrium
COSM312114	c.60A>T	p.P20P	Substitution - coding silent	Lung
COSM999866	c.2680G>A	p.D894N	Substitution - Missense	Endometrium
COSM4941937	c.2977T>A	p.Y993N	Substitution - Missense	Liver
COSM1211742	c.2053G>A	p.A685T	Substitution - Missense	Large_intestine
COSM1304966	c.2204C>G	p.S735C	Substitution - Missense	Urinary_tract
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM2754058	c.670G>T	p.A224S	Substitution - Missense	Large_intestine
COSM3960333	c.1850G>T	p.R617L	Substitution - Missense	Lung
COSM3938229	c.2373C>T	p.H791H	Substitution - coding silent	Oesophagus
COSM2755427	c.2467G>A	p.A823T	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1211739	c.2557G>A	p.V853M	Substitution - Missense	Large_intestine
COSM999819	c.1524C>T	p.V508V	Substitution - coding silent	Oesophagus
COSM5550359	c.2032G>A	p.A678T	Substitution - Missense	Prostate
COSM5134295	c.2820C>T	p.I940I	Substitution - coding silent	Large_intestine
COSM4468194	c.1530C>T	p.P510P	Substitution - coding silent	Skin
COSM6003791	c.1786-7G>C	p.?	Unknown	Prostate
COSM1711632	c.2201C>T	p.T734I	Substitution - Missense	Skin
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM1211736	c.1523T>C	p.V508A	Substitution - Missense	Large_intestine
COSM4080437	c.945G>A	p.K315K	Substitution - coding silent	Stomach
COSM5185342	c.2220G>A	p.T740T	Substitution - coding silent	Large_intestine
COSM1196237	c.2957G>T	p.R986L	Substitution - Missense	Lung
COSM4474447	c.1920C>T	p.F640F	Substitution - coding silent	Skin
COSM4817865	c.1255G>A	p.E419K	Substitution - Missense	Skin
COSM3537171	c.847G>C	p.G283R	Substitution - Missense	Skin
COSM5760792	c.2789G>A	p.R930H	Substitution - Missense	Pancreas
COSM137679	c.2933C>T	p.S978F	Substitution - Missense	Lung
COSM1394640	c.1590C>T	p.Y530Y	Substitution - coding silent	Large_intestine
COSM211883	c.343T>G	p.F115V	Substitution - Missense	Breast
COSM1394661	c.2889T>C	p.P963P	Substitution - coding silent	Liver
COSM4844542	c.2994C>T	p.I998I	Substitution - coding silent	Cervix
COSM4817865	c.1255G>A	p.E419K	Substitution - Missense	Skin
COSM4694967	c.1632C>T	p.H544H	Substitution - coding silent	Large_intestine
COSM999518	c.392C>T	p.P131L	Substitution - Missense	Pancreas
COSM1195906	c.886C>T	p.R296W	Substitution - Missense	Lung
COSM4897065	c.471C>T	p.I157I	Substitution - coding silent	Skin
COSM4694969	c.2724delG	p.G910fs*7	Deletion - Frameshift	Large_intestine
COSM999628	c.729G>A	p.M243I	Substitution - Missense	Endometrium
COSM4080262	c.586T>C	p.Y196H	Substitution - Missense	Stomach
COSM2755255	c.1677G>A	p.P559P	Substitution - coding silent	Skin
COSM4457771	c.1059C>T	p.P353P	Substitution - coding silent	Large_intestine
COSM4694959	c.170G>A	p.R57Q	Substitution - Missense	Large_intestine
COSM4650517	c.1197G>A	p.A399A	Substitution - coding silent	Large_intestine
COSM296008	c.705C>T	p.C235C	Substitution - coding silent	Large_intestine
COSM3960294	c.147C>G	p.I49M	Substitution - Missense	Lung
COSM4836063	c.3031G>C	p.E1011Q	Substitution - Missense	Cervix
COSM1394641	c.1712C>T	p.T571M	Substitution - Missense	Large_intestine
COSM4632806	c.1332G>A	p.K444K	Substitution - coding silent	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM3757070	c.1080A>G	p.A360A	Substitution - coding silent	Large_intestine
COSM4835905	c.2775C>T	p.V925V	Substitution - coding silent	Cervix
COSM4526891	c.1426G>A	p.E476K	Substitution - Missense	Skin
COSM4694971	c.3155G>T	p.G1052V	Substitution - Missense	Large_intestine
COSM5454765	c.1196C>T	p.A399V	Substitution - Missense	Large_intestine
COSM4979210	c.55C>T	p.R19C	Substitution - Missense	Oesophagus
COSM1166023	c.1631A>G	p.H544R	Substitution - Missense	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM5814256	c.1465G>A	p.V489M	Substitution - Missense	Liver
COSM1394637	c.1375T>G	p.F459V	Substitution - Missense	Large_intestine
COSM3835431	c.735C>T	p.L245L	Substitution - coding silent	Breast
COSM5981417	c.3134C>T	p.P1045L	Substitution - Missense	Upper_aerodigestive_tract
COSM459874	c.2240C>G	p.S747C	Substitution - Missense	Cervix
COSM3537169	c.817C>T	p.P273S	Substitution - Missense	Skin
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4080505	c.1862G>A	p.R621Q	Substitution - Missense	Stomach
COSM4694961	c.177G>A	p.T59T	Substitution - coding silent	Large_intestine
COSM3757070	c.1080A>G	p.A360A	Substitution - coding silent	Oesophagus
COSM336571	c.1036C>T	p.R346W	Substitution - Missense	Lung
COSM5162544	c.150C>T	p.P50P	Substitution - coding silent	Large_intestine
COSM140187	c.1579C>T	p.P527S	Substitution - Missense	Skin
COSM2754926	c.1037G>A	p.R346Q	Substitution - Missense	Stomach
COSM1394661	c.2889T>C	p.P963P	Substitution - coding silent	Liver
COSM1394661	c.2889T>C	p.P963P	Substitution - coding silent	Haematopoietic_and_lymphoid_tissue
COSM5185342	c.2220G>A	p.T740T	Substitution - coding silent	Large_intestine
COSM999819	c.1524C>T	p.V508V	Substitution - coding silent	Endometrium
COSM1612590	c.73T>C	p.F25L	Substitution - Missense	Liver
COSM5960270	c.2901G>A	p.T967T	Substitution - coding silent	Thyroid
COSM1196237	c.2957G>T	p.R986L	Substitution - Missense	Lung
COSM137679	c.2933C>T	p.S978F	Substitution - Missense	Skin
COSM4515956	c.1448_1449CC>TT	p.S483F	Substitution - Missense	Skin
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4080203	c.19G>A	p.G7S	Substitution - Missense	Stomach
COSM1211733	c.1001A>C	p.K334T	Substitution - Missense	Large_intestine
COSM1394660	c.2655C>T	p.A885A	Substitution - coding silent	Large_intestine
COSM2753752	c.359G>A	p.R120H	Substitution - Missense	Stomach
COSM3835481	c.2745C>G	p.L915L	Substitution - coding silent	Breast
COSM999866	c.2680G>A	p.D894N	Substitution - Missense	Stomach
COSM5056866	c.2162G>A	p.R721H	Substitution - Missense	Stomach
COSM1211735	c.2077T>C	p.Y693H	Substitution - Missense	Large_intestine
COSM4590120	c.2128A>G	p.K710E	Substitution - Missense	Upper_aerodigestive_tract
COSM4885722	c.2096C>A	p.T699N	Substitution - Missense	Upper_aerodigestive_tract
COSM4953986	c.197T>C	p.V66A	Substitution - Missense	Liver
COSM4953986	c.197T>C	p.V66A	Substitution - Missense	Liver
COSM4634443	c.1741G>T	p.G581W	Substitution - Missense	Large_intestine
COSM5624420	c.1603delC	p.P535fs*36	Deletion - Frameshift	Oesophagus
COSM5365267	c.678C>A	p.G226G	Substitution - coding silent	Large_intestine
COSM5096622	c.3238G>T	p.A1080S	Substitution - Missense	Large_intestine
COSM1394648	c.1851G>C	p.R617R	Substitution - coding silent	Large_intestine
COSM1564350	c.3125C>T	p.T1042M	Substitution - Missense	Large_intestine
COSM2753442	c.21C>T	p.G7G	Substitution - coding silent	Breast
COSM999448	c.104T>A	p.I35K	Substitution - Missense	Endometrium

> Text Mining based Variations [ TOP ]
There is no record for KDM4B.

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
O94953	602	K	N6-acetyllysine	-	No	None detected
O94953	1065	T	Phosphothreonine	-	No	None detected

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	5.463	5.625	0.169	0.307	NS
BRCA	Breast invasive carcinoma	112	1100	5.997	7.049	0.993	1.49e-20	Over
CESC	Cervical and endocervical cancers	3	306	5.826	5.383	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	5.738	5.451	-0.244	0.00793	NS
ESCA	Esophageal carcinoma	11	185	5.817	5.629	-0.43	0.0358	NS
GBM	Glioblastoma multiforme	5	166	5.906	5.84	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	5.467	5.315	-0.234	0.00429	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.113	5.935	0.862	2.11e-41	Over
KIRP	Kidney renal papillary cell carcinoma	32	291	5.574	5.674	0.145	0.134	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.349	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.649	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.905	4.808	-0.066	0.522	NS
LUAD	Lung adenocarcinoma	59	517	5.426	5.333	-0.033	0.688	NS
LUSC	Lung squamous cell carcinoma	51	501	5.347	5.525	0.225	0.02	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.674	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.512	5.334	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	6.479	5.496	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.407	6.951	0.536	2.35e-14	NS
READ	Rectum adenocarcinoma	10	167	5.528	5.344	0	0.999	NS
SARC	Sarcoma	2	263	5.095	5.696	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.243	5.533	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.796	5.43	-0.314	0.00218	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.687	NA	NA	NA
THCA	Thyroid carcinoma	59	509	6.621	5.913	-0.593	1.8e-16	Under
THYM	Thymoma	2	120	6.317	7.063	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.092	6.374	0.207	0.103	NS

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	7.9
Autonomic ganglia	CHP212	7.5
Autonomic ganglia	IMR32	8
Autonomic ganglia	KELLY	7.5
Autonomic ganglia	KPNRTBM1	8.6
Autonomic ganglia	KPNSI9S	7.4
Autonomic ganglia	KPNYN	8.2
Autonomic ganglia	MHHNB11	8.1
Autonomic ganglia	NB1	7.2
Autonomic ganglia	NH6	7.9
Autonomic ganglia	SHSY5Y	8.1
Autonomic ganglia	SIMA	8.1
Autonomic ganglia	SKNAS	7.4
Autonomic ganglia	SKNBE2	8.2
Autonomic ganglia	SKNDZ	7.6
Autonomic ganglia	SKNFI	7.7
Autonomic ganglia	SKNSH	7.7
Biliary tract	HUCCT1	7
Biliary tract	HUH28	7.2
Biliary tract	SNU1079	7.7
Biliary tract	SNU1196	6.9
Biliary tract	SNU245	6.7
Biliary tract	SNU308	6.7
Biliary tract	SNU478	7
Bone	143B	6.7
Bone	A673	7.9
Bone	CADOES1	7.7
Bone	CAL78	7.2
Bone	G292CLONEA141B1	7.8
Bone	HOS	7.3
Bone	HS706T	7.8
Bone	HS737T	7.6
Bone	HS819T	7.9
Bone	HS821T	7.8
Bone	HS822T	8
Bone	HS863T	7.1
Bone	HS870T	7.1
Bone	HS888T	7.3
Bone	MG63	7
Bone	MHHES1	7.8
Bone	OUMS27	7.1
Bone	RDES	7.5
Bone	SJSA1	7.6
Bone	SKES1	7.2
Bone	SKNMC	7.6
Bone	SW1353	8.3
Bone	T173	7.2
Bone	TC71	7.2
Bone	U2OS	6.9
Breast	AU565	6.9
Breast	BT20	7.1
Breast	BT474	8.2
Breast	BT483	8.2
Breast	BT549	7.2
Breast	CAL120	7.4
Breast	CAL148	8.2
Breast	CAL51	7.9
Breast	CAL851	6.8
Breast	CAMA1	9.6
Breast	DU4475	8.5
Breast	EFM192A	7.3
Breast	EFM19	9.5
Breast	EVSAT	7.6
Breast	HCC1143	6.5
Breast	HCC1187	7.7
Breast	HCC1395	6.6
Breast	HCC1419	8.4
Breast	HCC1428	9.2
Breast	HCC1500	8.9
Breast	HCC1569	7.2
Breast	HCC1599	7.5
Breast	HCC1806	7.2
Breast	HCC1937	6.6
Breast	HCC1954	7
Breast	HCC202	7.7
Breast	HCC2157	7.6
Breast	HCC2218	8.3
Breast	HCC38	7.7
Breast	HCC70	6.6
Breast	HDQP1	6.7
Breast	HMC18	7.2
Breast	HS274T	7.4
Breast	HS281T	7.3
Breast	HS343T	7.2
Breast	HS578T	8.6
Breast	HS606T	7.6
Breast	HS739T	7.8
Breast	HS742T	7.9
Breast	JIMT1	7.5
Breast	KPL1	7.2
Breast	MCF7	7.7
Breast	MDAMB134VI	9.5
Breast	MDAMB157	7.5
Breast	MDAMB175VII	7.8
Breast	MDAMB231	7.8
Breast	MDAMB361	7.8
Breast	MDAMB415	7.6
Breast	MDAMB436	6.7
Breast	MDAMB453	8.2
Breast	MDAMB468	7.1
Breast	SKBR3	7.4
Breast	T47D	9.2
Breast	UACC812	8.6
Breast	UACC893	6.9
Breast	YMB1	8
Breast	ZR751	7.5
Breast	ZR7530	8.3
Central nervous system	1321N1	7.6
Central nervous system	42MGBA	7.9
Central nervous system	8MGBA	5.8
Central nervous system	A172	8
Central nervous system	AM38	7.4
Central nervous system	BECKER	7.9
Central nervous system	CAS1	7.6
Central nervous system	CCFSTTG1	7.5
Central nervous system	D283MED	7.4
Central nervous system	D341MED	8.9
Central nervous system	DAOY	6.8
Central nervous system	DBTRG05MG	8.3
Central nervous system	DKMG	7.8
Central nervous system	GAMG	6.6
Central nervous system	GB1	7.2
Central nervous system	GI1	7.7
Central nervous system	GMS10	7.7
Central nervous system	GOS3	7.6
Central nervous system	H4	7.7
Central nervous system	HS683	7.6
Central nervous system	KALS1	8.1
Central nervous system	KG1C	7.8
Central nervous system	KNS42	7.6
Central nervous system	KNS60	7.6
Central nervous system	KNS81	7.4
Central nervous system	KS1	7.1
Central nervous system	LN18	7.1
Central nervous system	LN229	7
Central nervous system	M059K	7.5
Central nervous system	MOGGCCM	8
Central nervous system	MOGGUVW	7.7
Central nervous system	NMCG1	7.2
Central nervous system	ONS76	7.2
Central nervous system	SF126	7.6
Central nervous system	SF295	7.4
Central nervous system	SNB19	7.1
Central nervous system	SNU1105	8
Central nervous system	SNU201	7.8
Central nervous system	SNU466	8.7
Central nervous system	SNU489	8.2
Central nervous system	SNU626	7.4
Central nervous system	SNU738	7.6
Central nervous system	SW1088	7.3
Central nervous system	SW1783	7.3
Central nervous system	T98G	7.6
Central nervous system	TM31	8
Central nervous system	U118MG	7.5
Central nervous system	U138MG	7.6
Central nervous system	U251MG	7.9
Central nervous system	U87MG	8
Central nervous system	YH13	7.7
Central nervous system	YKG1	7.6
Endometrium	AN3CA	7.5
Endometrium	COLO684	9.1
Endometrium	EFE184	6.8
Endometrium	EN	7.9
Endometrium	ESS1	7.1
Endometrium	HEC108	7.6
Endometrium	HEC151	6.5
Endometrium	HEC1A	7.1
Endometrium	HEC1B	7.2
Endometrium	HEC251	7
Endometrium	HEC265	7.5
Endometrium	HEC50B	6.7
Endometrium	HEC59	8
Endometrium	HEC6	7.4
Endometrium	ISHIKAWAHERAKLIO02ER	7.4
Endometrium	JHUEM1	8.3
Endometrium	JHUEM2	8.2
Endometrium	JHUEM3	6.9
Endometrium	KLE	7.5
Endometrium	MFE280	7
Endometrium	MFE296	7.9
Endometrium	MFE319	7.5
Endometrium	RL952	7.6
Endometrium	SNGM	8.3
Endometrium	SNU1077	7.8
Endometrium	SNU685	7.5
Endometrium	TEN	7.2
Haematopoietic and lymphoid	697	7.2
Haematopoietic and lymphoid	A3KAW	7.6
Haematopoietic and lymphoid	A4FUK	7.5
Haematopoietic and lymphoid	ALLSIL	7.4
Haematopoietic and lymphoid	AML193	7.9
Haematopoietic and lymphoid	AMO1	7.6
Haematopoietic and lymphoid	BCP1	8.1
Haematopoietic and lymphoid	BDCM	8.4
Haematopoietic and lymphoid	BL41	8.7
Haematopoietic and lymphoid	BL70	8.7
Haematopoietic and lymphoid	BV173	7.4
Haematopoietic and lymphoid	CA46	8.8
Haematopoietic and lymphoid	CI1	7.7
Haematopoietic and lymphoid	CMK115	7.3
Haematopoietic and lymphoid	CMK86	7.9
Haematopoietic and lymphoid	CMK	8.2
Haematopoietic and lymphoid	CMLT1	9.8
Haematopoietic and lymphoid	COLO775	7.6
Haematopoietic and lymphoid	DAUDI	8.5
Haematopoietic and lymphoid	DB	9
Haematopoietic and lymphoid	DEL	7.3
Haematopoietic and lymphoid	DND41	8.8
Haematopoietic and lymphoid	DOHH2	8.7
Haematopoietic and lymphoid	EB1	8.3
Haematopoietic and lymphoid	EB2	8.2
Haematopoietic and lymphoid	EHEB	9
Haematopoietic and lymphoid	EJM	7.7
Haematopoietic and lymphoid	EM2	8
Haematopoietic and lymphoid	EOL1	8.1
Haematopoietic and lymphoid	F36P	7.3
Haematopoietic and lymphoid	GA10	8.2
Haematopoietic and lymphoid	GDM1	7.5
Haematopoietic and lymphoid	GRANTA519	8
Haematopoietic and lymphoid	HDLM2	7.1
Haematopoietic and lymphoid	HDMYZ	7
Haematopoietic and lymphoid	HEL9217	7
Haematopoietic and lymphoid	HEL	7.1
Haematopoietic and lymphoid	HH	6.7
Haematopoietic and lymphoid	HL60	8
Haematopoietic and lymphoid	HPBALL	9.8
Haematopoietic and lymphoid	HS604T	7.8
Haematopoietic and lymphoid	HS611T	8.5
Haematopoietic and lymphoid	HS616T	7.9
Haematopoietic and lymphoid	HS751T	7.3
Haematopoietic and lymphoid	HT	8.6
Haematopoietic and lymphoid	HTK	7.4
Haematopoietic and lymphoid	HUNS1	7.4
Haematopoietic and lymphoid	HUT102	7.4
Haematopoietic and lymphoid	HUT78	8
Haematopoietic and lymphoid	JEKO1	9.3
Haematopoietic and lymphoid	JK1	7.8
Haematopoietic and lymphoid	JM1	7.4
Haematopoietic and lymphoid	JURKAT	8.1
Haematopoietic and lymphoid	JURLMK1	7.6
Haematopoietic and lymphoid	JVM2	9.6
Haematopoietic and lymphoid	JVM3	8.6
Haematopoietic and lymphoid	K562	8
Haematopoietic and lymphoid	KARPAS299	7.4
Haematopoietic and lymphoid	KARPAS422	8.9
Haematopoietic and lymphoid	KARPAS620	7.9
Haematopoietic and lymphoid	KASUMI1	8.3
Haematopoietic and lymphoid	KASUMI2	6.7
Haematopoietic and lymphoid	KASUMI6	7.9
Haematopoietic and lymphoid	KCL22	8
Haematopoietic and lymphoid	KE37	7.6
Haematopoietic and lymphoid	KE97	7
Haematopoietic and lymphoid	KG1	7.7
Haematopoietic and lymphoid	KHM1B	8.4
Haematopoietic and lymphoid	KIJK	7.7
Haematopoietic and lymphoid	KMH2	7.2
Haematopoietic and lymphoid	KMM1	7.6
Haematopoietic and lymphoid	KMS11	7.7
Haematopoietic and lymphoid	KMS12BM	7.5
Haematopoietic and lymphoid	KMS18	7.7
Haematopoietic and lymphoid	KMS20	7.6
Haematopoietic and lymphoid	KMS21BM	7.8
Haematopoietic and lymphoid	KMS26	7.5
Haematopoietic and lymphoid	KMS27	7.6
Haematopoietic and lymphoid	KMS28BM	7.9
Haematopoietic and lymphoid	KMS34	7.5
Haematopoietic and lymphoid	KO52	7.9
Haematopoietic and lymphoid	KOPN8	7.9
Haematopoietic and lymphoid	KU812	8.4
Haematopoietic and lymphoid	KYO1	8.9
Haematopoietic and lymphoid	L1236	7.8
Haematopoietic and lymphoid	L363	8.6
Haematopoietic and lymphoid	L428	6.8
Haematopoietic and lymphoid	L540	8
Haematopoietic and lymphoid	LAMA84	7.5
Haematopoietic and lymphoid	LOUCY	8.4
Haematopoietic and lymphoid	LP1	7.8
Haematopoietic and lymphoid	M07E	7.9
Haematopoietic and lymphoid	MC116	8.1
Haematopoietic and lymphoid	ME1	8.2
Haematopoietic and lymphoid	MEC1	8.3
Haematopoietic and lymphoid	MEC2	9
Haematopoietic and lymphoid	MEG01	8.3
Haematopoietic and lymphoid	MHHCALL2	7.4
Haematopoietic and lymphoid	MHHCALL3	7.5
Haematopoietic and lymphoid	MHHCALL4	8.2
Haematopoietic and lymphoid	MINO	9.4
Haematopoietic and lymphoid	MJ	7.4
Haematopoietic and lymphoid	MM1S	8.1
Haematopoietic and lymphoid	MOLM13	8
Haematopoietic and lymphoid	MOLM16	9.3
Haematopoietic and lymphoid	MOLM6	9.3
Haematopoietic and lymphoid	MOLP2	8.3
Haematopoietic and lymphoid	MOLP8	8.4
Haematopoietic and lymphoid	MOLT13	7.5
Haematopoietic and lymphoid	MOLT16	8
Haematopoietic and lymphoid	MOLT4	7
Haematopoietic and lymphoid	MONOMAC1	7.8
Haematopoietic and lymphoid	MONOMAC6	8
Haematopoietic and lymphoid	MOTN1	7.9
Haematopoietic and lymphoid	MUTZ5	9.1
Haematopoietic and lymphoid	MV411	9
Haematopoietic and lymphoid	NALM19	8
Haematopoietic and lymphoid	NALM1	8.3
Haematopoietic and lymphoid	NALM6	7
Haematopoietic and lymphoid	NAMALWA	9.1
Haematopoietic and lymphoid	NB4	7.4
Haematopoietic and lymphoid	NCIH929	7.6
Haematopoietic and lymphoid	NCO2	7.7
Haematopoietic and lymphoid	NOMO1	7.3
Haematopoietic and lymphoid	NUDHL1	10.2
Haematopoietic and lymphoid	NUDUL1	8.6
Haematopoietic and lymphoid	OCIAML2	7.5
Haematopoietic and lymphoid	OCIAML3	9.3
Haematopoietic and lymphoid	OCIAML5	8.8
Haematopoietic and lymphoid	OCILY10	8.7
Haematopoietic and lymphoid	OCILY19	9.5
Haematopoietic and lymphoid	OCILY3	7.7
Haematopoietic and lymphoid	OCIM1	8.3
Haematopoietic and lymphoid	OPM2	7.8
Haematopoietic and lymphoid	P12ICHIKAWA	7.5
Haematopoietic and lymphoid	P31FUJ	8.3
Haematopoietic and lymphoid	P3HR1	7.5
Haematopoietic and lymphoid	PCM6	7.6
Haematopoietic and lymphoid	PEER	7.5
Haematopoietic and lymphoid	PF382	7.6
Haematopoietic and lymphoid	PFEIFFER	8.3
Haematopoietic and lymphoid	PL21	8.1
Haematopoietic and lymphoid	RAJI	7.8
Haematopoietic and lymphoid	RCHACV	7.3
Haematopoietic and lymphoid	REC1	9.8
Haematopoietic and lymphoid	REH	7.7
Haematopoietic and lymphoid	RI1	9.9
Haematopoietic and lymphoid	RL	8
Haematopoietic and lymphoid	RPMI8226	7.6
Haematopoietic and lymphoid	RPMI8402	7.8
Haematopoietic and lymphoid	RS411	7.7
Haematopoietic and lymphoid	SEM	7.8
Haematopoietic and lymphoid	SET2	7
Haematopoietic and lymphoid	SIGM5	8.4
Haematopoietic and lymphoid	SKM1	7.9
Haematopoietic and lymphoid	SKMM2	8
Haematopoietic and lymphoid	SR786	7.5
Haematopoietic and lymphoid	ST486	8.2
Haematopoietic and lymphoid	SUDHL10	9.5
Haematopoietic and lymphoid	SUDHL1	7.3
Haematopoietic and lymphoid	SUDHL4	9.7
Haematopoietic and lymphoid	SUDHL5	8.4
Haematopoietic and lymphoid	SUDHL6	8.7
Haematopoietic and lymphoid	SUDHL8	8.2
Haematopoietic and lymphoid	SUPB15	7.7
Haematopoietic and lymphoid	SUPHD1	8.6
Haematopoietic and lymphoid	SUPM2	7.2
Haematopoietic and lymphoid	SUPT11	8.3
Haematopoietic and lymphoid	SUPT1	7.8
Haematopoietic and lymphoid	TALL1	6.7
Haematopoietic and lymphoid	TF1	7.1
Haematopoietic and lymphoid	THP1	7.4
Haematopoietic and lymphoid	TO175T	7.3
Haematopoietic and lymphoid	TOLEDO	7.2
Haematopoietic and lymphoid	U266B1	8
Haematopoietic and lymphoid	U937	8.5
Haematopoietic and lymphoid	UT7	9
Haematopoietic and lymphoid	WSUDLCL2	8.4
Kidney	769P	7.1
Kidney	786O	7.3
Kidney	A498	7.6
Kidney	A704	7.7
Kidney	ACHN	6.6
Kidney	BFTC909	7.4
Kidney	CAKI1	7.7
Kidney	CAKI2	7.8
Kidney	CAL54	7.2
Kidney	KMRC1	6.7
Kidney	KMRC20	6.3
Kidney	KMRC2	7.9
Kidney	KMRC3	8
Kidney	OSRC2	7.4
Kidney	RCC10RGB	8.3
Kidney	SNU1272	8.4
Kidney	SNU349	8.8
Kidney	TUHR10TKB	7.9
Kidney	TUHR14TKB	8.1
Kidney	TUHR4TKB	8.4
Kidney	VMRCRCW	7.5
Kidney	VMRCRCZ	8.1
Large intestine	C2BBE1	7.1
Large intestine	CCK81	7.4
Large intestine	CL11	7.2
Large intestine	CL14	7.7
Large intestine	CL34	7.3
Large intestine	CL40	7.9
Large intestine	COLO205	6.5
Large intestine	COLO320	7.6
Large intestine	COLO678	7.9
Large intestine	CW2	7.4
Large intestine	DLD1	7.3
Large intestine	GP2D	7.5
Large intestine	HCC56	7.6
Large intestine	HCT116	7.1
Large intestine	HCT15	7.4
Large intestine	HS675T	7.3
Large intestine	HS698T	7.5
Large intestine	HT115	7
Large intestine	HT29	7
Large intestine	HT55	7.6
Large intestine	KM12	6.7
Large intestine	LOVO	7.5
Large intestine	LS1034	7.7
Large intestine	LS123	7.8
Large intestine	LS180	7.6
Large intestine	LS411N	7.3
Large intestine	LS513	7
Large intestine	MDST8	7.9
Large intestine	NCIH508	7.4
Large intestine	NCIH716	7.4
Large intestine	NCIH747	7.1
Large intestine	OUMS23	8.2
Large intestine	RCM1	7
Large intestine	RKO	6.6
Large intestine	SKCO1	7.2
Large intestine	SNU1040	7.7
Large intestine	SNU1197	7.6
Large intestine	SNU175	8
Large intestine	SNU283	6.8
Large intestine	SNU407	7.4
Large intestine	SNU503	7.4
Large intestine	SNU61	6.9
Large intestine	SNU81	7.6
Large intestine	SNUC1	7.5
Large intestine	SNUC2A	7.2
Large intestine	SNUC4	7.5
Large intestine	SNUC5	7.3
Large intestine	SW1116	7
Large intestine	SW1417	7.1
Large intestine	SW1463	7.2
Large intestine	SW403	7.1
Large intestine	SW480	6.7
Large intestine	SW48	7.5
Large intestine	SW620	7.1
Large intestine	SW837	6.5
Large intestine	SW948	7.8
Large intestine	T84	7.5
Liver	ALEXANDERCELLS	6.5
Liver	C3A	7.6
Liver	HEP3B217	7.4
Liver	HEPG2	7.6
Liver	HLE	6.3
Liver	HLF	7
Liver	HUH1	6.8
Liver	HUH6	7.5
Liver	HUH7	8
Liver	JHH1	7.4
Liver	JHH2	8.1
Liver	JHH4	6.7
Liver	JHH5	7.4
Liver	JHH6	6.9
Liver	JHH7	6.9
Liver	LI7	6.8
Liver	PLCPRF5	6.8
Liver	SKHEP1	7.1
Liver	SNU182	7.3
Liver	SNU387	7.5
Liver	SNU398	7.3
Liver	SNU423	7.9
Liver	SNU449	6.8
Liver	SNU475	7.2
Liver	SNU761	7.9
Liver	SNU878	6.6
Liver	SNU886	7.5
Lung	A549	6.4
Lung	ABC1	6.9
Lung	BEN	7.8
Lung	CAL12T	7.6
Lung	CALU1	7.2
Lung	CALU3	6.2
Lung	CALU6	6.7
Lung	CHAGOK1	6.6
Lung	COLO668	7.5
Lung	COLO699	7.5
Lung	CORL105	7.8
Lung	CORL23	7.2
Lung	CORL24	8.8
Lung	CORL279	9.5
Lung	CORL311	8.3
Lung	CORL47	8.6
Lung	CORL51	9
Lung	CORL88	7.3
Lung	CORL95	8.5
Lung	CPCN	8.4
Lung	DMS114	6.6
Lung	DMS153	7.3
Lung	DMS273	8.3
Lung	DMS454	6.9
Lung	DMS53	7
Lung	DMS79	8.4
Lung	DV90	7.2
Lung	EBC1	7.2
Lung	EPLC272H	7.5
Lung	HARA	7.1
Lung	HCC1171	7.4
Lung	HCC1195	5.9
Lung	HCC15	6.7
Lung	HCC2279	8.2
Lung	HCC2935	7.4
Lung	HCC33	8.4
Lung	HCC366	7.3
Lung	HCC4006	5.8
Lung	HCC44	6.6
Lung	HCC78	7.5
Lung	HCC827	7.3
Lung	HCC95	6.5
Lung	HLC1	7.5
Lung	HLFA	7.2
Lung	HS229T	7
Lung	HS618T	7
Lung	IALM	8.2
Lung	KNS62	6.6
Lung	LC1F	7.2
Lung	LC1SQSF	7.2
Lung	LCLC103H	7
Lung	LCLC97TM1	6.8
Lung	LK2	7.5
Lung	LOUNH91	7.2
Lung	LU65	7.2
Lung	LU99	6.8
Lung	LUDLU1	7.1
Lung	LXF289	7.7
Lung	MORCPR	7.3
Lung	NCIH1048	7.8
Lung	NCIH1092	7.7
Lung	NCIH1105	8.3
Lung	NCIH1155	7.1
Lung	NCIH1184	7.8
Lung	NCIH1299	6.8
Lung	NCIH1339	7.7
Lung	NCIH1341	8.1
Lung	NCIH1355	6.7
Lung	NCIH1373	6.9
Lung	NCIH1385	7.4
Lung	NCIH1395	8
Lung	NCIH1435	6.6
Lung	NCIH1436	7.4
Lung	NCIH1437	6.9
Lung	NCIH146	7.2
Lung	NCIH1563	8
Lung	NCIH1568	8.5
Lung	NCIH1573	6.6
Lung	NCIH1581	6.9
Lung	NCIH1618	9.5
Lung	NCIH1623	7.5
Lung	NCIH1648	7.5
Lung	NCIH1650	6.8
Lung	NCIH1651	6.8
Lung	NCIH1666	7.3
Lung	NCIH1693	6
Lung	NCIH1694	6.8
Lung	NCIH1703	6.5
Lung	NCIH1734	7.2
Lung	NCIH1755	7
Lung	NCIH1781	7.1
Lung	NCIH1792	6.5
Lung	NCIH1793	7.5
Lung	NCIH1836	8.2
Lung	NCIH1838	7.2
Lung	NCIH1869	6.7
Lung	NCIH1876	8.3
Lung	NCIH1915	7.7
Lung	NCIH1930	7.4
Lung	NCIH1944	6.1
Lung	NCIH1963	8.1
Lung	NCIH196	7.3
Lung	NCIH1975	8
Lung	NCIH2009	7.4
Lung	NCIH2023	6.3
Lung	NCIH2029	8.4
Lung	NCIH2030	7.1
Lung	NCIH2066	7.9
Lung	NCIH2081	7.6
Lung	NCIH2085	7
Lung	NCIH2087	6.8
Lung	NCIH209	8.4
Lung	NCIH2106	8
Lung	NCIH2110	7.3
Lung	NCIH211	7.6
Lung	NCIH2122	7.3
Lung	NCIH2126	6.8
Lung	NCIH2141	8.9
Lung	NCIH2170	6.9
Lung	NCIH2171	8.6
Lung	NCIH2172	6.8
Lung	NCIH2196	6.9
Lung	NCIH2227	7.6
Lung	NCIH2228	7.1
Lung	NCIH226	7.2
Lung	NCIH2286	6.9
Lung	NCIH2291	7
Lung	NCIH2342	6.7
Lung	NCIH2347	6.9
Lung	NCIH23	6.6
Lung	NCIH2405	6.6
Lung	NCIH2444	7.7
Lung	NCIH292	7
Lung	NCIH322	7
Lung	NCIH3255	7.4
Lung	NCIH358	7
Lung	NCIH441	7.2
Lung	NCIH446	8.1
Lung	NCIH460	6.5
Lung	NCIH510	8
Lung	NCIH520	8
Lung	NCIH522	7.6
Lung	NCIH524	8.5
Lung	NCIH526	7.9
Lung	NCIH596	7.1
Lung	NCIH647	6.7
Lung	NCIH650	7.1
Lung	NCIH661	6.6
Lung	NCIH69	8.1
Lung	NCIH727	7.3
Lung	NCIH810	7.5
Lung	NCIH82	7.3
Lung	NCIH838	6.6
Lung	NCIH841	7
Lung	NCIH854	9
Lung	NCIH889	8.1
Lung	PC14	7.2
Lung	RERFLCAD1	7.3
Lung	RERFLCAD2	6.7
Lung	RERFLCAI	7
Lung	RERFLCKJ	6.8
Lung	RERFLCMS	6.8
Lung	RERFLCSQ1	7.5
Lung	SBC5	6.9
Lung	SCLC21H	8.4
Lung	SHP77	7.3
Lung	SKLU1	7.3
Lung	SKMES1	6.4
Lung	SQ1	6.9
Lung	SW1271	7.4
Lung	SW1573	8.3
Lung	SW900	6.9
Lung	VMRCLCD	7.1
Lung	VMRCLCP	7.2
Oesophagus	COLO680N	7.3
Oesophagus	ECGI10	7
Oesophagus	KYSE140	7.2
Oesophagus	KYSE150	7.2
Oesophagus	KYSE180	6.9
Oesophagus	KYSE270	7.8
Oesophagus	KYSE30	7.6
Oesophagus	KYSE410	7.4
Oesophagus	KYSE450	7.2
Oesophagus	KYSE510	6.7
Oesophagus	KYSE520	7.4
Oesophagus	KYSE70	7.8
Oesophagus	OE19	7.3
Oesophagus	OE33	6.8
Oesophagus	TE10	7.3
Oesophagus	TE11	7
Oesophagus	TE14	7.2
Oesophagus	TE15	6.8
Oesophagus	TE1	6.5
Oesophagus	TE4	7.2
Oesophagus	TE5	7.6
Oesophagus	TE6	7.2
Oesophagus	TE8	8.3
Oesophagus	TE9	7.4
Oesophagus	TT	7.6
Ovary	59M	7.9
Ovary	A2780	7.5
Ovary	CAOV3	6.3
Ovary	CAOV4	7.8
Ovary	COLO704	8.6
Ovary	COV318	7.6
Ovary	COV362	6.6
Ovary	COV434	7.5
Ovary	COV504	6.6
Ovary	COV644	7.9
Ovary	EFO21	7.1
Ovary	EFO27	8.1
Ovary	ES2	6.8
Ovary	FUOV1	7.4
Ovary	HEYA8	6.8
Ovary	HS571T	7.8
Ovary	IGROV1	8.2
Ovary	JHOC5	6.7
Ovary	JHOM1	7.5
Ovary	JHOM2B	7.4
Ovary	JHOS2	7.3
Ovary	JHOS4	5.9
Ovary	KURAMOCHI	7.7
Ovary	MCAS	6.6
Ovary	NIHOVCAR3	7.4
Ovary	OAW28	6.8
Ovary	OAW42	7.5
Ovary	OC314	6.9
Ovary	OC316	7.1
Ovary	ONCODG1	7.2
Ovary	OV56	7.5
Ovary	OV7	7.7
Ovary	OV90	7.4
Ovary	OVCAR4	7.3
Ovary	OVCAR8	7.5
Ovary	OVISE	7
Ovary	OVK18	8
Ovary	OVKATE	7.8
Ovary	OVMANA	7.4
Ovary	OVSAHO	7
Ovary	OVTOKO	7.7
Ovary	RMGI	7.4
Ovary	RMUGS	7.1
Ovary	SKOV3	7.3
Ovary	SNU119	6.6
Ovary	SNU840	7
Ovary	SNU8	6.9
Ovary	TOV112D	7.2
Ovary	TOV21G	8.2
Ovary	TYKNU	6.3
Pancreas	ASPC1	7
Pancreas	BXPC3	6.8
Pancreas	CAPAN1	7
Pancreas	CAPAN2	6.1
Pancreas	CFPAC1	6.7
Pancreas	DANG	6.8
Pancreas	HPAC	8
Pancreas	HPAFII	6.9
Pancreas	HS766T	6.7
Pancreas	HUPT3	6.9
Pancreas	HUPT4	7.4
Pancreas	KCIMOH1	7.1
Pancreas	KLM1	6.7
Pancreas	KP2	7.5
Pancreas	KP3	6.5
Pancreas	KP4	6.7
Pancreas	L33	7.3
Pancreas	MIAPACA2	8.3
Pancreas	PANC0203	7
Pancreas	PANC0213	8.2
Pancreas	PANC0327	7
Pancreas	PANC0403	6.9
Pancreas	PANC0504	7.7
Pancreas	PANC0813	6.8
Pancreas	PANC1005	6.8
Pancreas	PANC1	6.6
Pancreas	PATU8902	6.1
Pancreas	PATU8988S	6.8
Pancreas	PATU8988T	7
Pancreas	PK1	6.4
Pancreas	PK45H	6.8
Pancreas	PK59	7.4
Pancreas	PL45	6.6
Pancreas	PSN1	7.4
Pancreas	QGP1	7.6
Pancreas	SNU213	7.7
Pancreas	SNU324	7.6
Pancreas	SNU410	7.2
Pancreas	SU8686	6.8
Pancreas	SUIT2	6.9
Pancreas	SW1990	7
Pancreas	T3M4	6.6
Pancreas	TCCPAN2	6.5
Pancreas	YAPC	7.5
Pleura	ACCMESO1	6.6
Pleura	DM3	7.7
Pleura	ISTMES1	7.4
Pleura	ISTMES2	7
Pleura	JL1	7.5
Pleura	MPP89	7.1
Pleura	MSTO211H	6.8
Pleura	NCIH2052	7.1
Pleura	NCIH2452	7.3
Pleura	NCIH28	8
Prostate	22RV1	8.2
Prostate	DU145	7
Prostate	LNCAPCLONEFGC	8.9
Prostate	MDAPCA2B	9.1
Prostate	NCIH660	8.7
Prostate	PC3	7.5
Prostate	VCAP	8.2
Salivary gland	A253	7.6
Salivary gland	YD15	6.2
Skin	A101D	7.4
Skin	A2058	7.4
Skin	A375	7.1
Skin	C32	7.9
Skin	CHL1	7.6
Skin	CJM	6.7
Skin	COLO679	7.3
Skin	COLO741	7.3
Skin	COLO783	7.5
Skin	COLO792	6.8
Skin	COLO800	7.2
Skin	COLO818	6.8
Skin	COLO829	7.7
Skin	COLO849	8.3
Skin	G361	7
Skin	GRM	7.7
Skin	HMCB	7.4
Skin	HS294T	7.5
Skin	HS600T	7.2
Skin	HS688AT	7.9
Skin	HS695T	7.3
Skin	HS839T	7
Skin	HS852T	7.4
Skin	HS895T	7.3
Skin	HS934T	6.8
Skin	HS936T	7.5
Skin	HS939T	7.2
Skin	HS940T	7.8
Skin	HS944T	6.5
Skin	HT144	7.8
Skin	IGR1	7.6
Skin	IGR37	7.9
Skin	IGR39	7.1
Skin	IPC298	7.1
Skin	K029AX	7.4
Skin	LOXIMVI	7
Skin	MALME3M	7
Skin	MDAMB435S	6.8
Skin	MELHO	6.6
Skin	MELJUSO	7.3
Skin	MEWO	7.4
Skin	RPMI7951	7.1
Skin	RVH421	7.6
Skin	SH4	7.5
Skin	SKMEL1	7.3
Skin	SKMEL24	7.8
Skin	SKMEL28	7.4
Skin	SKMEL2	7.1
Skin	SKMEL30	7.3
Skin	SKMEL31	7.4
Skin	SKMEL3	6.3
Skin	SKMEL5	6.5
Skin	UACC257	7.1
Skin	UACC62	8
Skin	WM115	7.5
Skin	WM1799	6.8
Skin	WM2664	7.3
Skin	WM793	6.9
Skin	WM88	7.2
Skin	WM983B	6.9
Small intestine	HUTU80	7.5
Soft tissue	A204	6.6
Soft tissue	G401	7.4
Soft tissue	G402	7.1
Soft tissue	GCT	6.8
Soft tissue	HS729	7.8
Soft tissue	HT1080	7.6
Soft tissue	KYM1	7
Soft tissue	MESSA	7.4
Soft tissue	RD	7.6
Soft tissue	RH30	8.5
Soft tissue	RH41	7.4
Soft tissue	RKN	6.7
Soft tissue	S117	8.3
Soft tissue	SJRH30	8.2
Soft tissue	SKLMS1	7.8
Soft tissue	SKUT1	8.4
Soft tissue	TE125T	7.2
Soft tissue	TE159T	7.5
Soft tissue	TE441T	8.6
Soft tissue	TE617T	7.1
Stomach	2313287	7.3
Stomach	AGS	8.2
Stomach	AZ521	7.5
Stomach	ECC10	8
Stomach	ECC12	7.7
Stomach	FU97	6.8
Stomach	GCIY	6.7
Stomach	GSS	7.1
Stomach	GSU	7.4
Stomach	HGC27	7.5
Stomach	HS746T	8.4
Stomach	HUG1N	6.8
Stomach	IM95	7.3
Stomach	KATOIII	6.2
Stomach	KE39	6.9
Stomach	LMSU	7.5
Stomach	MKN1	6.9
Stomach	MKN45	7.4
Stomach	MKN74	6.9
Stomach	MKN7	7.6
Stomach	NCCSTCK140	7.9
Stomach	NCIN87	6.7
Stomach	NUGC2	7.8
Stomach	NUGC3	6.6
Stomach	NUGC4	7.1
Stomach	OCUM1	7.7
Stomach	RERFGC1B	7.4
Stomach	SH10TC	6.9
Stomach	SNU16	7.4
Stomach	SNU1	7.8
Stomach	SNU216	7.3
Stomach	SNU520	7.3
Stomach	SNU5	6.9
Stomach	SNU601	7.5
Stomach	SNU620	7.4
Stomach	SNU668	7.3
Stomach	SNU719	7.7
Stomach	TGBC11TKB	7.6
Thyroid	8305C	7.2
Thyroid	8505C	7.7
Thyroid	BCPAP	7.7
Thyroid	BHT101	7.5
Thyroid	CAL62	7.3
Thyroid	CGTHW1	7.2
Thyroid	FTC133	7.8
Thyroid	FTC238	7.3
Thyroid	ML1	7.5
Thyroid	SW579	7.2
Thyroid	TT2609C02	7.1
Thyroid	TT	8.1
Upper aerodigestive tract	BHY	6.7
Upper aerodigestive tract	BICR16	7.5
Upper aerodigestive tract	BICR18	7.3
Upper aerodigestive tract	BICR22	7.6
Upper aerodigestive tract	BICR31	7.4
Upper aerodigestive tract	BICR56	7.8
Upper aerodigestive tract	BICR6	7.7
Upper aerodigestive tract	CAL27	7.5
Upper aerodigestive tract	CAL33	7.3
Upper aerodigestive tract	DETROIT562	6.9
Upper aerodigestive tract	FADU	6.7
Upper aerodigestive tract	HS840T	7.3
Upper aerodigestive tract	HSC2	7.2
Upper aerodigestive tract	HSC3	6.6
Upper aerodigestive tract	HSC4	7.5
Upper aerodigestive tract	PECAPJ15	7.1
Upper aerodigestive tract	PECAPJ34CLONEC12	7.2
Upper aerodigestive tract	PECAPJ41CLONED2	7.7
Upper aerodigestive tract	PECAPJ49	7.9
Upper aerodigestive tract	SCC15	7.1
Upper aerodigestive tract	SCC25	6.7
Upper aerodigestive tract	SCC4	7.5
Upper aerodigestive tract	SCC9	7.4
Upper aerodigestive tract	SNU1076	7.3
Upper aerodigestive tract	SNU1214	6.3
Upper aerodigestive tract	SNU46	7.5
Upper aerodigestive tract	SNU899	7.1
Upper aerodigestive tract	YD10B	7.2
Upper aerodigestive tract	YD38	6.8
Upper aerodigestive tract	YD8	8
Urinary tract	5637	7.5
Urinary tract	639V	7.7
Urinary tract	647V	7.3
Urinary tract	BC3C	7.3
Urinary tract	BFTC905	6.9
Urinary tract	CAL29	7.2
Urinary tract	HS172T	6.9
Urinary tract	HT1197	8.4
Urinary tract	HT1376	7
Urinary tract	J82	7.1
Urinary tract	JMSU1	7.9
Urinary tract	KMBC2	7.3
Urinary tract	KU1919	7.2
Urinary tract	RT11284	7.9
Urinary tract	RT112	7.8
Urinary tract	RT4	7.1
Urinary tract	SCABER	7
Urinary tract	SW1710	7.7
Urinary tract	SW780	7.7
Urinary tract	T24	7.5
Urinary tract	TCCSUP	7.2
Urinary tract	UMUC1	7.8
Urinary tract	UMUC3	7.4
Urinary tract	VMCUB1	6.9

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	8.5
Adrenal gland	10.1
Appendix	12.3
Bone marrow	9
Breast	12.7
Cerebral cortex	14.3
Cervix, uterine	14
Colon	5.7
Duodenum	6.8
Endometrium	13.1
Epididymis	8.2
Esophagus	7.7
Fallopian tube	12.8
Gallbladder	7.4
Heart muscle	4.7
Kidney	4.2
Liver	3
Lung	9
Lymph node	13.8
Ovary	9.5
Pancreas	2.2
Parathyroid gland	9.9
Placenta	13.5
Prostate	15.7
Rectum	3.3
Salivary gland	4.1
Seminal vesicle	10.5
Skeletal muscle	7.1
Skin	14.2
Small intestine	8.1
Smooth muscle	7.1
Spleen	17.4
Stomach	6
Testis	17.7
Thyroid gland	19.8
Tonsil	7
Urinary bladder	6.6

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26397136	Overexpression	Endometrial Carcinoma	In clinical specimens, both KDM4B and KDM4A expression are significantly higher in EC tissues than that in normal endometrium.
26101715	Overexpression	Breast Carcinoma	We demonstrated that KDM4A and D are also significantly overexpressed in basal-like breast cancer, whereas KDM4B overexpression is more dominant in estrogen-receptor-positive, luminal breast cancer.
25636512	Overexpression	Osteosarcoma	JMJD2B and JMJD2C were up-regulated in osteosarcoma tissues when compared to paired adjacent non-tumor tissues.
25533242	Overexpression	Hepatocellular Carcinoma	These results reveal that JMJD2B is dramatically upregulated in HCC, making it a potential diagnostic marker for the further development of HCC treatment therapies.
24077348	Overexpression	Gastric Carcinoma	The expression of JMJD2B was positively correlated with tumor size (P = 0.017), differentiation status (P = 0.002), tumor invasion (P = 0.045), lymph node metastasis (P = 0.000), distant metastasis (P = 0.024), and tumor-node-metastasis (TNM) stage (P = 0.002) in patients with gastric cancer.
22745382	Overexpression	Colorectal Carcinoma	We also showed that JMJD2B was overexpressed in CRC tissues and positively correlated with expression of the hypoxic marker carbonic anhydrase 9 (CA9), deeper depth of invasion and advanced clinical stages.
21930796	Overexpression	Bladder Carcinoma; Lung Carcinoma	Quantitative real-time PCR showed notably elevated levels of JMJD2B expression in bladder cancers, compared with corresponding nonneoplastic tissues (P < 0.0001), and elevated protein expression was confirmed by immunohistochemistry; In addition, cDNA microarray analysis revealed transactivation of JMJD2B in lung cancer, and immunohistochemical analysis showed protein overexpression in lung cancer.
21445275	Overexpression	Breast Carcinoma	JMJD2B is expressed in a high proportion of human breast tumors, and that expression levels significantly correlate with estrogen receptor (ER) positivity.
27869162	Overexpression	Ovarian Carcinoma	Epithelial ovarian cancer (EOC) has poor prognosis and rapid recurrence because of widespread dissemination of peritoneal metastases at diagnosis. Multiple pathways contribute to the aggressiveness of ovarian cancer, including hypoxic signaling mechanisms. In this study, we have determined that the hypoxia-inducible histone demethylase KDM4B is expressed in 60% of EOC tumors assayed, including primary and matched metastatic tumors. Expression of KDM4B in tumors is positively correlated with expression of the tumor hypoxia marker CA-IX, and is robustly induced in EOC cell lines exposed to hypoxia.

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.448	2.6e-21	33.4	51	15.6	Loss
BRCA	Breast invasive carcinoma	1075	0.268	4.24e-19	26.3	58	15.7	Neutral
CESC	Cervical and endocervical cancers	292	0.601	4.73e-30	34.2	55.1	10.6	Loss
COAD	Colon adenocarcinoma	449	0.362	2.52e-15	12.7	71.9	15.4	Neutral
ESCA	Esophageal carcinoma	183	0.572	2.89e-17	47	41	12	Loss
GBM	Glioblastoma multiforme	147	0.369	4.35e-06	8.2	55.8	36.1	Gain
HNSC	Head and Neck squamous cell carcinoma	514	0.4	3.42e-21	29.2	61.3	9.5	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.215	6.9e-07	3	88.2	8.8	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.39	6.77e-12	7.3	91.3	1.4	Neutral
LAML	Acute Myeloid Leukemia	166	0.22	0.00442	2.4	94.6	3	Neutral
LGG	Brain Lower Grade Glioma	513	0.146	0.000923	4.1	73.3	22.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.529	1.21e-27	23.4	62.9	13.7	Neutral
LUAD	Lung adenocarcinoma	512	0.285	5.2e-11	53.5	43.2	3.3	Loss
LUSC	Lung squamous cell carcinoma	498	0.405	4.88e-21	40.4	40.6	19.1	Loss
OV	Ovarian serous cystadenocarcinoma	300	0.556	1.01e-25	73.3	14.3	12.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.441	8.26e-10	18.1	75.1	6.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.284	0.000255	0.6	84	15.4	Neutral
PRAD	Prostate adenocarcinoma	491	0.165	0.000239	6.7	91.4	1.8	Neutral
READ	Rectum adenocarcinoma	164	0.542	6.23e-14	20.7	61	18.3	Neutral
SARC	Sarcoma	255	0.366	1.72e-09	14.1	47.5	38.4	Gain
SKCM	Skin Cutaneous Melanoma	367	0.409	3.06e-16	24.8	58.9	16.3	Neutral
STAD	Stomach adenocarcinoma	413	0.367	1.36e-14	35.1	58.1	6.8	Loss
TGCT	Testicular Germ Cell Tumors	150	0.227	0.00531	31.3	43.3	25.3	Neutral
THCA	Thyroid carcinoma	497	0.202	5.85e-06	1.6	97	1.4	Neutral
THYM	Thymoma	119	0.1	0.278	3.4	94.1	2.5	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.559	1.73e-45	25.9	70.2	3.9	Neutral

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.469	0	17	408	-0.049	0.000942	NS/NA
BRCA	Breast invasive carcinoma	-0.421	0	83	785	-0.067	3.55e-25	NS/NA
CESC	Cervical and endocervical cancers	-0.3	9.17e-08	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.146	0.00959	19	297	-0.001	0.487	NS/NA
ESCA	Esophageal carcinoma	-0.133	0.0645	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.145	0.247	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.193	6.23e-06	20	522	0.008	0.68	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.343	8.96e-11	24	319	-0.166	4.23e-39	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.253	1.09e-05	23	275	-0.016	0.411	NS/NA
LAML	Acute Myeloid Leukemia	-0.134	0.0812	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.157	0.000295	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.225	4.09e-06	41	373	-0.045	0.703	NS/NA
LUAD	Lung adenocarcinoma	-0.144	0.00159	21	456	-0.073	7.99e-05	NS/NA
LUSC	Lung squamous cell carcinoma	-0.286	1.77e-08	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.533	0.148	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.258	0.000429	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.209	0.00414	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.317	8.74e-14	35	498	-0.019	0.00292	NS/NA
READ	Rectum adenocarcinoma	-0.13	0.196	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.206	0.000791	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.133	0.0038	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.094	0.0698	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.125	0.121	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.429	0	50	509	0.093	2.51e-14	NS/NA
THYM	Thymoma	-0.637	0	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.4	0	34	431	0.034	1.61e-10	NS/NA

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA) [ TOP ]
There is no antibody staining data.

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	2.92e-05	Significant	24476821
BRCA	Breast invasive carcinoma	521	2.44e-48	Significant	23000897
COAD	Colon adenocarcinoma	149	0.0964	NS	22810696
GBM	Glioblastoma multiforme	157	1.77e-08	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	7.24e-06	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.07	NS	26536169
LGG	Brain Lower Grade Glioma	513	2.18e-28	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.359	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.0819	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.000243	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00261	Significant	26544944
READ	Rectum adenocarcinoma	67	0.526	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0174	Significant	26091043
STAD	Stomach adenocarcinoma	277	2.81e-05	Significant	25079317
THCA	Thyroid carcinoma	391	4.31e-32	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	6.62e-16	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.009	0.967	NS
BRCA	Breast invasive carcinoma	1079	0.542	0.00787	Longer
CESC	Cervical and endocervical cancers	291	0.874	0.701	NS
COAD	Colon adenocarcinoma	439	1.621	0.0868	NS
ESCA	Esophageal carcinoma	184	0.776	0.454	NS
GBM	Glioblastoma multiforme	158	0.854	0.532	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.73	0.111	NS
KIRC	Kidney renal clear cell carcinoma	531	1.192	0.377	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.551	0.168	NS
LAML	Acute Myeloid Leukemia	149	1.262	0.436	NS
LGG	Brain Lower Grade Glioma	511	0.391	0.000153	Longer
LIHC	Liver hepatocellular carcinoma	365	0.608	0.0539	NS
LUAD	Lung adenocarcinoma	502	0.954	0.819	NS
LUSC	Lung squamous cell carcinoma	494	0.969	0.871	NS
OV	Ovarian serous cystadenocarcinoma	303	1.089	0.685	NS
PAAD	Pancreatic adenocarcinoma	177	0.55	0.0382	Longer
PCPG	Pheochromocytoma and Paraganglioma	179	1.979	0.57	NS
PRAD	Prostate adenocarcinoma	497	526485196.446	0.065	NS
READ	Rectum adenocarcinoma	159	0.859	0.834	NS
SARC	Sarcoma	259	1.712	0.0652	NS
SKCM	Skin Cutaneous Melanoma	459	1.505	0.0234	Shorter
STAD	Stomach adenocarcinoma	388	0.744	0.187	NS
TGCT	Testicular Germ Cell Tumors	134	0.657	0.767	NS
THCA	Thyroid carcinoma	500	1.675	0.393	NS
THYM	Thymoma	119	1.252	0.789	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	0.261	1.14e-05	Longer

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.166	0.000791	Lower
BRCA	Breast invasive carcinoma	1071	-0.069	0.0235	Lower
CESC	Cervical and endocervical cancers	167	0.244	0.00146	Higher
COAD	Colon adenocarcinoma	445	0.012	0.794	NS
ESCA	Esophageal carcinoma	162	-0.105	0.184	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.029	0.542	NS
KIRC	Kidney renal clear cell carcinoma	531	0.082	0.0592	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.026	0.679	NS
LIHC	Liver hepatocellular carcinoma	347	-0.019	0.724	NS
LUAD	Lung adenocarcinoma	507	0.012	0.793	NS
LUSC	Lung squamous cell carcinoma	497	-0.048	0.282	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.08	0.165	NS
PAAD	Pancreatic adenocarcinoma	176	-0.181	0.0164	Lower
READ	Rectum adenocarcinoma	156	0.034	0.676	NS
SKCM	Skin Cutaneous Melanoma	410	-0.064	0.193	NS
STAD	Stomach adenocarcinoma	392	-0.032	0.524	NS
TGCT	Testicular Germ Cell Tumors	81	0.209	0.0606	NS
THCA	Thyroid carcinoma	499	-0.15	0.00076	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.231	1.78e-07	Lower

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.114	0.06	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.039	0.385	NS
KIRC	Kidney renal clear cell carcinoma	525	0.048	0.273	NS
LGG	Brain Lower Grade Glioma	514	-0.076	0.0838	NS
LIHC	Liver hepatocellular carcinoma	366	-0.173	0.00087	Lower
OV	Ovarian serous cystadenocarcinoma	296	0	0.994	NS
PAAD	Pancreatic adenocarcinoma	176	-0.117	0.122	NS
STAD	Stomach adenocarcinoma	406	0.073	0.141	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	-0.369	1.04e-18	Lower

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KDM4B.

Summary
Symbol	KDM4B
Name	lysine demethylase 4B
Aliases	KIAA0876; TDRD14B; tudor domain containing 14B; JMJD2B; jumonji domain containing 2B; jmjC domain-containing ......
Location	19p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
25533242	Hepatocellular Carcinoma	partner	Ki-67	correlation	Moreover, JMJD2B was also correlated with Ki-67 expression in HCC samples.
21445275	Breast Carcinoma	upstream	E2	positive regulation	In addition, 17-beta-estradiol (E2) induces JMJD2B expression in an ERα dependent manner.
21445275	Breast Carcinoma	partner	ERα	Interaction	JMJD2B interacts with ERα and components of the SWI/SNF-B chromatin remodeling complex.
21445275	Breast Carcinoma	downstream	MYB; MYC; CCND1	positive regulation	JMJD2B is recruited to ERα target sites, demethylates H3K9me3 and facilitates transcription of ER responsive genes including MYB, MYC and CCND1.