Browse KDM4E in pancancer

Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Domain, Function and Classification
> Gene Ontology
> KEGG and Reactome Pathway
> Domain, Function and Classification
 
Domain PF02373 JmjC domain
PF02375 jmjN domain
Function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.

Classification
Class Modification Substrate Product PubMed
Histone modification erase Histone methylation H3K9me2, H3K9me3 H3K9 21914792
> Gene Ontology
 
Biological Process -
Molecular Function GO:0051213 dioxygenase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Mutation landscape in primary tumor tissue from TCGA
> Mutation landscape in cancer cell line from CCLE
> All mutations from COSMIC database V81
> Variations from text mining
> The Cancer Genome Atlas (TCGA)
 
> Cancer Cell Line Encyclopedia (CCLE)
 
There is no record.
> Catalogue of Somatic Mutations in Cancer (COSMIC)
 
There is no record for KDM4E.
> Text Mining based Variations
 
There is no record for KDM4E.
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Post-translational modification (PTM)
> Post-translational modification (PTM)
 
There is no PTM data
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Expression analysis in primary tumor tissue from TCGA
> Expression level in cancer cell line from CCLE
> Expression level in human normal tissue from HPA
> Text mining based expression change
> The Cancer Genome Atlas (TCGA)
 


  Differential expression analysis for cancers with more than 10 normal samples
Cancer Full Name # N # T Median (N) Median (T) LogFC Adj. P Status
LAMLAcute Myeloid Leukemia0173NA-4.878NANANA
TGCTTesticular Germ Cell Tumors0156NA-2.02NANANA
> Cancer Cell Line Encyclopedia (CCLE)
 

There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Expression Level (TPM)
Adipose tissue 0
Adrenal gland 0
Appendix 0
Bone marrow 0
Breast 0.1
Cerebral cortex 0
Cervix, uterine 0
Colon 0
Duodenum 0
Endometrium 0.1
Epididymis 0
Esophagus 0
Fallopian tube 0
Gallbladder 0
Heart muscle 0
Kidney 0
Liver 0
Lung 0
Lymph node 0
Ovary 0
Pancreas 0
Parathyroid gland 0
Placenta 0.3
Prostate 0.1
Rectum 0
Salivary gland 0.1
Seminal vesicle 0
Skeletal muscle 0
Skin 0.3
Small intestine 0
Smooth muscle 0
Spleen 0.1
Stomach 0
Testis 0.4
Thyroid gland 0.2
Tonsil 0
Urinary bladder 0
> Text Mining based Expression
 
There is no record.
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Somatic copy number alteration in primary tomur tissue
> The Cancer Genome Atlas (TCGA)
 


  Correlation between expression and SCNA as well as percentage of patients in different status.
Cancer Full Name # Sample R P % Loss % Neutral % Gain Status
LAMLAcute Myeloid Leukemia1660.250.00116095.84.2Neutral
TGCTTesticular Germ Cell Tumors1500.1850.023278.719.32Loss
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Methylation level in the promoter region of CR
> Methylation level in the promoter region of CR
 


  Correlation between expression and methylation as well as differential methylation analysis.
Cancer Full Name R P # N # T Delta beta (T vs N) P value (T vs N) Status
LAMLAcute Myeloid Leukemia-0.0950.2150170NANANS/NA
TGCTTesticular Germ Cell Tumors-0.2340.003280156NANANS/NA
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Primary tumor tissue from TCGA
> Normal tumor tissue from HPA
>The Cancer Genome Atlas (TCGA)
 
There is no record.
> The Human Protein Atlas (HPA)
 


Tissue Level Level Name
Adrenal gland 2 Medium
Appendix 3 High
Bone marrow 1 Low
Breast 2 Medium
Bronchus 3 High
Caudate 3 High
Cerebellum 2 Medium
Cerebral cortex 3 High
Cervix, uterine 3 High
Colon 3 High
Duodenum 3 High
Endometrium 3 High
Epididymis 3 High
Esophagus 3 High
Fallopian tube 3 High
Gallbladder 3 High
Heart muscle 2 Medium
Hippocampus 3 High
Kidney 2 Medium
Liver 2 Medium
Lung 2 Medium
Lymph node 3 High
Nasopharynx 3 High
Oral mucosa 3 High
Ovary 1 Low
Pancreas 3 High
Parathyroid gland 2 Medium
Placenta 2 Medium
Prostate 2 Medium
Rectum 3 High
Salivary gland 2 Medium
Seminal vesicle 2 Medium
Skeletal muscle 2 Medium
Skin 3 High
Small intestine 2 Medium
Smooth muscle 2 Medium
Soft tissue 3 High
Spleen 2 Medium
Stomach 2 Medium
Testis 2 Medium
Thyroid gland 3 High
Tonsil 3 High
Urinary bladder 3 High
Vagina 3 High
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Association between expresson and subtype
> Overall survival analysis based on expression
> Association between expresson and stage
> Association between expresson and grade
> Subtype
 
There is no record.
> Overall survival
 

  Overall survival analysis based on expression.
Cancer Full Name # Patients Hazard Ratio P Value (Log Rank Test) Association
LAMLAcute Myeloid Leukemia149 0.9170.759NS
TGCTTesticular Germ Cell Tumors134 594299979.4260.317NS
> Stage
 

  Association between expresson and stage.
Cancer Full Name # Patients R Value (Spearman) P Value (Spearman) Association
TGCTTesticular Germ Cell Tumors81 0.0950.398NS
> Grade
 
There is no data.
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Targets inferred by reverse engineering method
> Targets identified by ChIP-seq data
> Targets inferred by reverse engineering method
 
> Targets identified by ChIP-seq data
 
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Drugs from DrugBank database
> Drugs from DrugBank database
 
There is no record for KDM4E.
Summary
SymbolKDM4E
Namelysine demethylase 4E
Aliases JMJD2E; KDM4DL; lysine (K)-specific demethylase 4D-like; KDM4D-like protein; Lysine-specific demethylase 4D- ......
Location11q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content > Protein-Protein Interaction Network
> miRNA Regulatory Relationship
> Interactions from Text Mining
> Protein-Protein Interaction Network
 
> miRNA Regulatory Relationship
 
There is no record for KDM4E.
> Interactions from Text Mining
 
There is no record for KDM4E.