CR2Cancer

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

[ TOP ]

Domain

PF01388 ARID/BRIGHT DNA binding domain
PF02373 JmjC domain
PF02375 jmjN domain
PF00628 PHD-finger
PF08429 PLU-1-like protein
PF02928 C5HC2 zinc finger

Function

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase	Histone methylation	H3K4me3	H3K4	17363312

> Gene Ontology [ TOP ]
Biological Process	GO:0001654 eye development GO:0001763 morphogenesis of a branching structure GO:0002088 lens development in camera-type eye GO:0006482 protein demethylation GO:0006869 lipid transport GO:0007338 single fertilization GO:0007423 sensory organ development GO:0008214 protein dealkylation GO:0009566 fertilization GO:0009636 response to toxic substance GO:0009791 post-embryonic development GO:0010876 lipid localization GO:0015850 organic hydroxy compound transport GO:0016570 histone modification GO:0016577 histone demethylation GO:0022612 gland morphogenesis GO:0030879 mammary gland development GO:0032368 regulation of lipid transport GO:0033598 mammary gland epithelial cell proliferation GO:0033599 regulation of mammary gland epithelial cell proliferation GO:0033601 positive regulation of mammary gland epithelial cell proliferation GO:0034720 histone H3-K4 demethylation GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific GO:0035239 tube morphogenesis GO:0035938 estradiol secretion GO:0043010 camera-type eye development GO:0044344 cellular response to fibroblast growth factor stimulus GO:0048511 rhythmic process GO:0048608 reproductive structure development GO:0048732 gland development GO:0048754 branching morphogenesis of an epithelial tube GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0060065 uterus development GO:0060443 mammary gland morphogenesis GO:0060444 branching involved in mammary gland duct morphogenesis GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060603 mammary gland duct morphogenesis GO:0060763 mammary duct terminal end bud growth GO:0060992 response to fungicide GO:0061038 uterus morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061180 mammary gland epithelium development GO:0061458 reproductive system development GO:0070076 histone lysine demethylation GO:0070306 lens fiber cell differentiation GO:0070988 demethylation GO:0071774 response to fibroblast growth factor GO:2000864 regulation of estradiol secretion
Molecular Function	GO:0003714 transcription corepressor activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0032453 histone demethylase activity (H3-K4 specific) GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific) GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) GO:0051213 dioxygenase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3214842: HDMs demethylate histones R-HSA-8866911: TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

[ TOP ]

COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM22854	c.4658G>C	p.R1553T	Substitution - Missense	Urinary_tract
COSM69206	c.2943_2944insG	p.F982fs*32	Insertion - Frameshift	Ovary
COSM136208	c.2321C>T	p.A774V	Substitution - Missense	Skin
COSM50784	c.4715A>G	p.K1572R	Substitution - Missense	Breast
COSM50914	c.1993G>T	p.E665*	Substitution - Nonsense	Breast
COSM71282	c.2632C>A	p.L878I	Substitution - Missense	Ovary

> Text Mining based Variations [ TOP ]
There is no record for KDM5B.

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

[ TOP ]

Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q9UGL1	986	S	Phosphoserine	-	No	None detected
Q9UGL1	1328	S	Phosphoserine	-	No	None detected
Q9UGL1	1456	S	Phosphoserine	-	No	None detected

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	6.503	6.825	0.423	0.019	NS
BRCA	Breast invasive carcinoma	112	1100	6.629	7.518	0.949	3.26e-43	Over
CESC	Cervical and endocervical cancers	3	306	6.123	6.663	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	6.284	6.121	-0.127	0.255	NS
ESCA	Esophageal carcinoma	11	185	6.363	6.993	0.485	0.0609	NS
GBM	Glioblastoma multiforme	5	166	5.94	5.82	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	6.773	7.031	0.409	0.00115	NS
KIRC	Kidney renal clear cell carcinoma	72	534	5.901	5.9	-0.025	0.668	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	5.523	5.677	0.099	0.384	NS
LAML	Acute Myeloid Leukemia	0	173	NA	7.841	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.188	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	4.043	4.677	0.581	0.000144	Over
LUAD	Lung adenocarcinoma	59	517	5.893	6.878	1.005	4.55e-32	Over
LUSC	Lung squamous cell carcinoma	51	501	5.881	7.076	1.189	9.44e-35	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	6.804	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	6.4	6.486	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	5.358	5.292	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	6.267	6.592	0.312	9.55e-06	NS
READ	Rectum adenocarcinoma	10	167	6.026	6.113	0.161	0.553	NS
SARC	Sarcoma	2	263	5.146	5.689	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.98	6.492	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	5.743	6.297	0.333	0.00649	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.565	NA	NA	NA
THCA	Thyroid carcinoma	59	509	5.856	6.154	0.255	0.000149	NS
THYM	Thymoma	2	120	6.362	6.051	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	6.381	6.994	0.68	5.03e-08	Over

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	10.3
Autonomic ganglia	CHP212	9.5
Autonomic ganglia	IMR32	9.7
Autonomic ganglia	KELLY	9.8
Autonomic ganglia	KPNRTBM1	9.9
Autonomic ganglia	KPNSI9S	10.1
Autonomic ganglia	KPNYN	9.9
Autonomic ganglia	MHHNB11	10.8
Autonomic ganglia	NB1	9.3
Autonomic ganglia	NH6	9.2
Autonomic ganglia	SHSY5Y	11.2
Autonomic ganglia	SIMA	10.1
Autonomic ganglia	SKNAS	9.8
Autonomic ganglia	SKNBE2	10.3
Autonomic ganglia	SKNDZ	8.7
Autonomic ganglia	SKNFI	8.9
Autonomic ganglia	SKNSH	8.8
Biliary tract	HUCCT1	8.9
Biliary tract	HUH28	9.5
Biliary tract	SNU1079	10.2
Biliary tract	SNU1196	7.6
Biliary tract	SNU245	9.2
Biliary tract	SNU308	9
Biliary tract	SNU478	8.7
Bone	143B	7.9
Bone	A673	8.5
Bone	CADOES1	9.4
Bone	CAL78	8.5
Bone	G292CLONEA141B1	9.1
Bone	HOS	8.6
Bone	HS706T	9.5
Bone	HS737T	9.4
Bone	HS819T	9.2
Bone	HS821T	9.2
Bone	HS822T	9.4
Bone	HS863T	8.5
Bone	HS870T	8.5
Bone	HS888T	9.1
Bone	MG63	8.4
Bone	MHHES1	10.8
Bone	OUMS27	8.8
Bone	RDES	9.4
Bone	SJSA1	8.1
Bone	SKES1	9.6
Bone	SKNMC	9.1
Bone	SW1353	9.6
Bone	T173	8.9
Bone	TC71	8.1
Bone	U2OS	8.2
Breast	AU565	9.2
Breast	BT20	9.3
Breast	BT474	10
Breast	BT483	11.7
Breast	BT549	9.1
Breast	CAL120	8.9
Breast	CAL148	11.9
Breast	CAL51	9.6
Breast	CAL851	8.4
Breast	CAMA1	9.3
Breast	DU4475	8.7
Breast	EFM192A	9.5
Breast	EFM19	9.9
Breast	EVSAT	8.2
Breast	HCC1143	8
Breast	HCC1187	10.8
Breast	HCC1395	7
Breast	HCC1419	9.8
Breast	HCC1428	8.7
Breast	HCC1500	9.7
Breast	HCC1569	9.2
Breast	HCC1599	10.6
Breast	HCC1806	10.8
Breast	HCC1937	9.1
Breast	HCC1954	9.4
Breast	HCC202	10.5
Breast	HCC2157	9.7
Breast	HCC2218	10.6
Breast	HCC38	9.2
Breast	HCC70	9.5
Breast	HDQP1	9.4
Breast	HMC18	9
Breast	HS274T	9.4
Breast	HS281T	8.9
Breast	HS343T	9
Breast	HS578T	9.8
Breast	HS606T	9.4
Breast	HS739T	9.5
Breast	HS742T	9.4
Breast	JIMT1	9.5
Breast	KPL1	10.5
Breast	MCF7	10.1
Breast	MDAMB134VI	9
Breast	MDAMB157	9.1
Breast	MDAMB175VII	10.8
Breast	MDAMB231	8.6
Breast	MDAMB361	9.6
Breast	MDAMB415	10.4
Breast	MDAMB436	9.1
Breast	MDAMB453	9.3
Breast	MDAMB468	9.4
Breast	SKBR3	9
Breast	T47D	10.1
Breast	UACC812	11.3
Breast	UACC893	9.5
Breast	YMB1	10.6
Breast	ZR751	10.2
Breast	ZR7530	10.9
Central nervous system	1321N1	7.5
Central nervous system	42MGBA	8.6
Central nervous system	8MGBA	8.5
Central nervous system	A172	9.5
Central nervous system	AM38	7.3
Central nervous system	BECKER	8.5
Central nervous system	CAS1	9.2
Central nervous system	CCFSTTG1	6.6
Central nervous system	D283MED	8.9
Central nervous system	D341MED	10.1
Central nervous system	DAOY	9.1
Central nervous system	DBTRG05MG	8.7
Central nervous system	DKMG	9.1
Central nervous system	GAMG	7.3
Central nervous system	GB1	5.4
Central nervous system	GI1	9.6
Central nervous system	GMS10	9
Central nervous system	GOS3	8.8
Central nervous system	H4	9.2
Central nervous system	HS683	8.6
Central nervous system	KALS1	9.6
Central nervous system	KG1C	8.5
Central nervous system	KNS42	8.9
Central nervous system	KNS60	9.8
Central nervous system	KNS81	8.8
Central nervous system	KS1	7.4
Central nervous system	LN18	7.7
Central nervous system	LN229	8.2
Central nervous system	M059K	8.7
Central nervous system	MOGGCCM	8.8
Central nervous system	MOGGUVW	9.1
Central nervous system	NMCG1	8.2
Central nervous system	ONS76	9.6
Central nervous system	SF126	9
Central nervous system	SF295	8.2
Central nervous system	SNB19	7.9
Central nervous system	SNU1105	9.2
Central nervous system	SNU201	9.1
Central nervous system	SNU466	8.9
Central nervous system	SNU489	9.2
Central nervous system	SNU626	8.5
Central nervous system	SNU738	9.6
Central nervous system	SW1088	8.5
Central nervous system	SW1783	9
Central nervous system	T98G	9.3
Central nervous system	TM31	9.1
Central nervous system	U118MG	6.9
Central nervous system	U138MG	8.4
Central nervous system	U251MG	9.2
Central nervous system	U87MG	7.8
Central nervous system	YH13	9
Central nervous system	YKG1	9.7
Endometrium	AN3CA	9.5
Endometrium	COLO684	10.2
Endometrium	EFE184	9.7
Endometrium	EN	9.3
Endometrium	ESS1	8.5
Endometrium	HEC108	8.7
Endometrium	HEC151	7.5
Endometrium	HEC1A	7.3
Endometrium	HEC1B	8.5
Endometrium	HEC251	8.5
Endometrium	HEC265	6.6
Endometrium	HEC50B	7.5
Endometrium	HEC59	9.4
Endometrium	HEC6	8.9
Endometrium	ISHIKAWAHERAKLIO02ER	8.5
Endometrium	JHUEM1	9.4
Endometrium	JHUEM2	10.3
Endometrium	JHUEM3	9.5
Endometrium	KLE	9.5
Endometrium	MFE280	9.5
Endometrium	MFE296	8.7
Endometrium	MFE319	9
Endometrium	RL952	10.6
Endometrium	SNGM	10
Endometrium	SNU1077	10.5
Endometrium	SNU685	10.1
Endometrium	TEN	8.8
Haematopoietic and lymphoid	697	10.7
Haematopoietic and lymphoid	A3KAW	8.9
Haematopoietic and lymphoid	A4FUK	4.7
Haematopoietic and lymphoid	ALLSIL	8.2
Haematopoietic and lymphoid	AML193	10.2
Haematopoietic and lymphoid	AMO1	9
Haematopoietic and lymphoid	BCP1	4.4
Haematopoietic and lymphoid	BDCM	7.7
Haematopoietic and lymphoid	BL41	5.1
Haematopoietic and lymphoid	BL70	4.8
Haematopoietic and lymphoid	BV173	10.2
Haematopoietic and lymphoid	CA46	4.5
Haematopoietic and lymphoid	CI1	4.9
Haematopoietic and lymphoid	CMK115	9.2
Haematopoietic and lymphoid	CMK86	10.8
Haematopoietic and lymphoid	CMK	9.9
Haematopoietic and lymphoid	CMLT1	10.1
Haematopoietic and lymphoid	COLO775	4.6
Haematopoietic and lymphoid	DAUDI	4.6
Haematopoietic and lymphoid	DB	4.5
Haematopoietic and lymphoid	DEL	4.7
Haematopoietic and lymphoid	DND41	5.8
Haematopoietic and lymphoid	DOHH2	5.3
Haematopoietic and lymphoid	EB1	8.2
Haematopoietic and lymphoid	EB2	8
Haematopoietic and lymphoid	EHEB	6.4
Haematopoietic and lymphoid	EJM	7
Haematopoietic and lymphoid	EM2	9.5
Haematopoietic and lymphoid	EOL1	9.2
Haematopoietic and lymphoid	F36P	9.1
Haematopoietic and lymphoid	GA10	5
Haematopoietic and lymphoid	GDM1	9.8
Haematopoietic and lymphoid	GRANTA519	7.7
Haematopoietic and lymphoid	HDLM2	4.8
Haematopoietic and lymphoid	HDMYZ	8.1
Haematopoietic and lymphoid	HEL9217	9.2
Haematopoietic and lymphoid	HEL	9.2
Haematopoietic and lymphoid	HH	4.8
Haematopoietic and lymphoid	HL60	9.2
Haematopoietic and lymphoid	HPBALL	10.3
Haematopoietic and lymphoid	HS604T	9.4
Haematopoietic and lymphoid	HS611T	7.9
Haematopoietic and lymphoid	HS616T	9.8
Haematopoietic and lymphoid	HS751T	9.1
Haematopoietic and lymphoid	HT	6
Haematopoietic and lymphoid	HTK	8.1
Haematopoietic and lymphoid	HUNS1	7.2
Haematopoietic and lymphoid	HUT102	8.3
Haematopoietic and lymphoid	HUT78	5.9
Haematopoietic and lymphoid	JEKO1	7.9
Haematopoietic and lymphoid	JK1	10.3
Haematopoietic and lymphoid	JM1	8.3
Haematopoietic and lymphoid	JURKAT	9.3
Haematopoietic and lymphoid	JURLMK1	9.6
Haematopoietic and lymphoid	JVM2	5.2
Haematopoietic and lymphoid	JVM3	4.3
Haematopoietic and lymphoid	K562	9.7
Haematopoietic and lymphoid	KARPAS299	7.6
Haematopoietic and lymphoid	KARPAS422	5
Haematopoietic and lymphoid	KARPAS620	6.9
Haematopoietic and lymphoid	KASUMI1	10.3
Haematopoietic and lymphoid	KASUMI2	10.3
Haematopoietic and lymphoid	KASUMI6	10.7
Haematopoietic and lymphoid	KCL22	9.2
Haematopoietic and lymphoid	KE37	8.9
Haematopoietic and lymphoid	KE97	4.5
Haematopoietic and lymphoid	KG1	10.1
Haematopoietic and lymphoid	KHM1B	5.4
Haematopoietic and lymphoid	KIJK	4.8
Haematopoietic and lymphoid	KMH2	4.6
Haematopoietic and lymphoid	KMM1	9.6
Haematopoietic and lymphoid	KMS11	7.2
Haematopoietic and lymphoid	KMS12BM	6.5
Haematopoietic and lymphoid	KMS18	4.5
Haematopoietic and lymphoid	KMS20	9.5
Haematopoietic and lymphoid	KMS21BM	9.2
Haematopoietic and lymphoid	KMS26	7.3
Haematopoietic and lymphoid	KMS27	8.1
Haematopoietic and lymphoid	KMS28BM	7
Haematopoietic and lymphoid	KMS34	5.3
Haematopoietic and lymphoid	KO52	10.5
Haematopoietic and lymphoid	KOPN8	7.2
Haematopoietic and lymphoid	KU812	10.3
Haematopoietic and lymphoid	KYO1	10.5
Haematopoietic and lymphoid	L1236	6.4
Haematopoietic and lymphoid	L363	9.5
Haematopoietic and lymphoid	L428	4.9
Haematopoietic and lymphoid	L540	4.5
Haematopoietic and lymphoid	LAMA84	9.6
Haematopoietic and lymphoid	LOUCY	10.3
Haematopoietic and lymphoid	LP1	9.1
Haematopoietic and lymphoid	M07E	10.6
Haematopoietic and lymphoid	MC116	5
Haematopoietic and lymphoid	ME1	11.1
Haematopoietic and lymphoid	MEC1	6.9
Haematopoietic and lymphoid	MEC2	6.6
Haematopoietic and lymphoid	MEG01	9.4
Haematopoietic and lymphoid	MHHCALL2	9.1
Haematopoietic and lymphoid	MHHCALL3	9.9
Haematopoietic and lymphoid	MHHCALL4	7.4
Haematopoietic and lymphoid	MINO	7.5
Haematopoietic and lymphoid	MJ	7.3
Haematopoietic and lymphoid	MM1S	5
Haematopoietic and lymphoid	MOLM13	9.2
Haematopoietic and lymphoid	MOLM16	10.7
Haematopoietic and lymphoid	MOLM6	11.2
Haematopoietic and lymphoid	MOLP2	7.2
Haematopoietic and lymphoid	MOLP8	10.8
Haematopoietic and lymphoid	MOLT13	8.9
Haematopoietic and lymphoid	MOLT16	6.3
Haematopoietic and lymphoid	MOLT4	7.9
Haematopoietic and lymphoid	MONOMAC1	9.2
Haematopoietic and lymphoid	MONOMAC6	8.8
Haematopoietic and lymphoid	MOTN1	5.5
Haematopoietic and lymphoid	MUTZ5	9.3
Haematopoietic and lymphoid	MV411	9.6
Haematopoietic and lymphoid	NALM19	9.6
Haematopoietic and lymphoid	NALM1	10.1
Haematopoietic and lymphoid	NALM6	10.3
Haematopoietic and lymphoid	NAMALWA	5.1
Haematopoietic and lymphoid	NB4	10.7
Haematopoietic and lymphoid	NCIH929	8.3
Haematopoietic and lymphoid	NCO2	10.1
Haematopoietic and lymphoid	NOMO1	6.6
Haematopoietic and lymphoid	NUDHL1	9.3
Haematopoietic and lymphoid	NUDUL1	9.6
Haematopoietic and lymphoid	OCIAML2	10.4
Haematopoietic and lymphoid	OCIAML3	10.8
Haematopoietic and lymphoid	OCIAML5	10.4
Haematopoietic and lymphoid	OCILY10	4.9
Haematopoietic and lymphoid	OCILY19	10.8
Haematopoietic and lymphoid	OCILY3	8.2
Haematopoietic and lymphoid	OCIM1	9.7
Haematopoietic and lymphoid	OPM2	7.1
Haematopoietic and lymphoid	P12ICHIKAWA	9.2
Haematopoietic and lymphoid	P31FUJ	9
Haematopoietic and lymphoid	P3HR1	7.4
Haematopoietic and lymphoid	PCM6	4.7
Haematopoietic and lymphoid	PEER	9.9
Haematopoietic and lymphoid	PF382	9.7
Haematopoietic and lymphoid	PFEIFFER	8.6
Haematopoietic and lymphoid	PL21	9.3
Haematopoietic and lymphoid	RAJI	5.5
Haematopoietic and lymphoid	RCHACV	10.5
Haematopoietic and lymphoid	REC1	8.7
Haematopoietic and lymphoid	REH	10
Haematopoietic and lymphoid	RI1	8.9
Haematopoietic and lymphoid	RL	6
Haematopoietic and lymphoid	RPMI8226	5.2
Haematopoietic and lymphoid	RPMI8402	9.9
Haematopoietic and lymphoid	RS411	5.5
Haematopoietic and lymphoid	SEM	4.7
Haematopoietic and lymphoid	SET2	10.6
Haematopoietic and lymphoid	SIGM5	9.5
Haematopoietic and lymphoid	SKM1	10.2
Haematopoietic and lymphoid	SKMM2	5.2
Haematopoietic and lymphoid	SR786	5.1
Haematopoietic and lymphoid	ST486	5.4
Haematopoietic and lymphoid	SUDHL10	4.7
Haematopoietic and lymphoid	SUDHL1	7.3
Haematopoietic and lymphoid	SUDHL4	5.9
Haematopoietic and lymphoid	SUDHL5	5.1
Haematopoietic and lymphoid	SUDHL6	5.3
Haematopoietic and lymphoid	SUDHL8	4.9
Haematopoietic and lymphoid	SUPB15	9.2
Haematopoietic and lymphoid	SUPHD1	4.9
Haematopoietic and lymphoid	SUPM2	9
Haematopoietic and lymphoid	SUPT11	8.2
Haematopoietic and lymphoid	SUPT1	5.2
Haematopoietic and lymphoid	TALL1	10.1
Haematopoietic and lymphoid	TF1	8.8
Haematopoietic and lymphoid	THP1	9.3
Haematopoietic and lymphoid	TO175T	9.1
Haematopoietic and lymphoid	TOLEDO	8.7
Haematopoietic and lymphoid	U266B1	5.1
Haematopoietic and lymphoid	U937	10.2
Haematopoietic and lymphoid	UT7	10.8
Haematopoietic and lymphoid	WSUDLCL2	5.5
Kidney	769P	8.4
Kidney	786O	7.6
Kidney	A498	9.4
Kidney	A704	7.6
Kidney	ACHN	8.5
Kidney	BFTC909	8.9
Kidney	CAKI1	10.1
Kidney	CAKI2	5.9
Kidney	CAL54	9.2
Kidney	KMRC1	9.6
Kidney	KMRC20	4.9
Kidney	KMRC2	9
Kidney	KMRC3	9.6
Kidney	OSRC2	8.8
Kidney	RCC10RGB	8.2
Kidney	SNU1272	10
Kidney	SNU349	9
Kidney	TUHR10TKB	8.4
Kidney	TUHR14TKB	9.8
Kidney	TUHR4TKB	9.3
Kidney	VMRCRCW	9.1
Kidney	VMRCRCZ	9.1
Large intestine	C2BBE1	8.5
Large intestine	CCK81	7.1
Large intestine	CL11	9.3
Large intestine	CL14	9.8
Large intestine	CL34	8.4
Large intestine	CL40	9.9
Large intestine	COLO205	7.7
Large intestine	COLO320	9
Large intestine	COLO678	10.2
Large intestine	CW2	7.2
Large intestine	DLD1	6.9
Large intestine	GP2D	9.1
Large intestine	HCC56	9.3
Large intestine	HCT116	7.4
Large intestine	HCT15	6.4
Large intestine	HS675T	8.7
Large intestine	HS698T	9.7
Large intestine	HT115	8.2
Large intestine	HT29	8.7
Large intestine	HT55	8.1
Large intestine	KM12	7.8
Large intestine	LOVO	7.7
Large intestine	LS1034	7.3
Large intestine	LS123	9.6
Large intestine	LS180	7.8
Large intestine	LS411N	6.9
Large intestine	LS513	8.4
Large intestine	MDST8	8.7
Large intestine	NCIH508	8.7
Large intestine	NCIH716	7
Large intestine	NCIH747	8.6
Large intestine	OUMS23	11.2
Large intestine	RCM1	8.7
Large intestine	RKO	7.7
Large intestine	SKCO1	9.6
Large intestine	SNU1040	9.7
Large intestine	SNU1197	8.4
Large intestine	SNU175	9.2
Large intestine	SNU283	9
Large intestine	SNU407	10.8
Large intestine	SNU503	9.8
Large intestine	SNU61	9.8
Large intestine	SNU81	9.6
Large intestine	SNUC1	7.5
Large intestine	SNUC2A	9
Large intestine	SNUC4	9.1
Large intestine	SNUC5	8.9
Large intestine	SW1116	8
Large intestine	SW1417	8
Large intestine	SW1463	8.1
Large intestine	SW403	8.8
Large intestine	SW480	7.6
Large intestine	SW48	8.4
Large intestine	SW620	6
Large intestine	SW837	9.1
Large intestine	SW948	9.4
Large intestine	T84	8.3
Liver	ALEXANDERCELLS	8.5
Liver	C3A	8.4
Liver	HEP3B217	10.1
Liver	HEPG2	8.8
Liver	HLE	7.7
Liver	HLF	9
Liver	HUH1	8.1
Liver	HUH6	9
Liver	HUH7	8.3
Liver	JHH1	10
Liver	JHH2	9.2
Liver	JHH4	9.2
Liver	JHH5	9.4
Liver	JHH6	8.4
Liver	JHH7	8.8
Liver	LI7	7.2
Liver	PLCPRF5	8.8
Liver	SKHEP1	8.2
Liver	SNU182	9.5
Liver	SNU387	8.2
Liver	SNU398	9.7
Liver	SNU423	8.9
Liver	SNU449	9.6
Liver	SNU475	10.3
Liver	SNU761	10
Liver	SNU878	8
Liver	SNU886	8.7
Lung	A549	8.4
Lung	ABC1	9.2
Lung	BEN	9.4
Lung	CAL12T	7.7
Lung	CALU1	7.8
Lung	CALU3	8.9
Lung	CALU6	8.5
Lung	CHAGOK1	9.5
Lung	COLO668	8.3
Lung	COLO699	8.8
Lung	CORL105	9
Lung	CORL23	9.9
Lung	CORL24	10.2
Lung	CORL279	10.2
Lung	CORL311	9
Lung	CORL47	9
Lung	CORL51	9.9
Lung	CORL88	9.4
Lung	CORL95	9
Lung	CPCN	7.9
Lung	DMS114	9.5
Lung	DMS153	9.5
Lung	DMS273	8.9
Lung	DMS454	8.3
Lung	DMS53	8.8
Lung	DMS79	10.4
Lung	DV90	9.1
Lung	EBC1	6.7
Lung	EPLC272H	9.1
Lung	HARA	8.1
Lung	HCC1171	9
Lung	HCC1195	9.3
Lung	HCC15	7.5
Lung	HCC2279	8.9
Lung	HCC2935	8.8
Lung	HCC33	10
Lung	HCC366	8.3
Lung	HCC4006	9.5
Lung	HCC44	8.8
Lung	HCC78	9.9
Lung	HCC827	9
Lung	HCC95	8.3
Lung	HLC1	9.3
Lung	HLFA	8.6
Lung	HS229T	8.2
Lung	HS618T	8.6
Lung	IALM	9.1
Lung	KNS62	8.9
Lung	LC1F	9.9
Lung	LC1SQSF	8.9
Lung	LCLC103H	8.6
Lung	LCLC97TM1	9.3
Lung	LK2	9.3
Lung	LOUNH91	8.2
Lung	LU65	9
Lung	LU99	8.3
Lung	LUDLU1	8.9
Lung	LXF289	9.7
Lung	MORCPR	8.3
Lung	NCIH1048	10.3
Lung	NCIH1092	9.3
Lung	NCIH1105	10.4
Lung	NCIH1155	8.1
Lung	NCIH1184	9.7
Lung	NCIH1299	7.8
Lung	NCIH1339	9
Lung	NCIH1341	9.6
Lung	NCIH1355	9.4
Lung	NCIH1373	9.2
Lung	NCIH1385	10.7
Lung	NCIH1395	8.2
Lung	NCIH1435	8.1
Lung	NCIH1436	9.4
Lung	NCIH1437	8.9
Lung	NCIH146	10
Lung	NCIH1563	9.3
Lung	NCIH1568	8.1
Lung	NCIH1573	9.6
Lung	NCIH1581	9.1
Lung	NCIH1618	9.9
Lung	NCIH1623	8.2
Lung	NCIH1648	9
Lung	NCIH1650	9.2
Lung	NCIH1651	9.1
Lung	NCIH1666	10
Lung	NCIH1693	8.4
Lung	NCIH1694	8.5
Lung	NCIH1703	8.7
Lung	NCIH1734	8.4
Lung	NCIH1755	9
Lung	NCIH1781	10
Lung	NCIH1792	8.4
Lung	NCIH1793	9.1
Lung	NCIH1836	9.5
Lung	NCIH1838	8.7
Lung	NCIH1869	9.2
Lung	NCIH1876	10.3
Lung	NCIH1915	8.2
Lung	NCIH1930	9.9
Lung	NCIH1944	8.7
Lung	NCIH1963	10
Lung	NCIH196	7.7
Lung	NCIH1975	8.9
Lung	NCIH2009	8.9
Lung	NCIH2023	9.3
Lung	NCIH2029	8.5
Lung	NCIH2030	8.9
Lung	NCIH2066	9.2
Lung	NCIH2081	10
Lung	NCIH2085	9.4
Lung	NCIH2087	8.9
Lung	NCIH209	9.1
Lung	NCIH2106	9.7
Lung	NCIH2110	9.5
Lung	NCIH211	9.1
Lung	NCIH2122	9.2
Lung	NCIH2126	9.4
Lung	NCIH2141	9.5
Lung	NCIH2170	8.9
Lung	NCIH2171	8.3
Lung	NCIH2172	8.7
Lung	NCIH2196	8.6
Lung	NCIH2227	8.6
Lung	NCIH2228	8.9
Lung	NCIH226	7.2
Lung	NCIH2286	8
Lung	NCIH2291	7.3
Lung	NCIH2342	9.1
Lung	NCIH2347	9
Lung	NCIH23	8.4
Lung	NCIH2405	8.9
Lung	NCIH2444	9.3
Lung	NCIH292	9.4
Lung	NCIH322	8.9
Lung	NCIH3255	9.2
Lung	NCIH358	8.1
Lung	NCIH441	9.1
Lung	NCIH446	9.9
Lung	NCIH460	7.7
Lung	NCIH510	8.8
Lung	NCIH520	8.4
Lung	NCIH522	10.2
Lung	NCIH524	8.3
Lung	NCIH526	9.2
Lung	NCIH596	9.2
Lung	NCIH647	8.8
Lung	NCIH650	8.6
Lung	NCIH661	9
Lung	NCIH69	8.6
Lung	NCIH727	8.2
Lung	NCIH810	9.5
Lung	NCIH82	9.2
Lung	NCIH838	8.7
Lung	NCIH841	9.7
Lung	NCIH854	10
Lung	NCIH889	9.4
Lung	PC14	9.1
Lung	RERFLCAD1	8.9
Lung	RERFLCAD2	8.2
Lung	RERFLCAI	7.9
Lung	RERFLCKJ	8.7
Lung	RERFLCMS	9.2
Lung	RERFLCSQ1	9.4
Lung	SBC5	10.1
Lung	SCLC21H	9.5
Lung	SHP77	9.1
Lung	SKLU1	8.1
Lung	SKMES1	9
Lung	SQ1	9.3
Lung	SW1271	8
Lung	SW1573	8.6
Lung	SW900	9.4
Lung	VMRCLCD	9.4
Lung	VMRCLCP	9.9
Oesophagus	COLO680N	9
Oesophagus	ECGI10	10.1
Oesophagus	KYSE140	8.9
Oesophagus	KYSE150	7.5
Oesophagus	KYSE180	8.9
Oesophagus	KYSE270	9.6
Oesophagus	KYSE30	10
Oesophagus	KYSE410	7.6
Oesophagus	KYSE450	10
Oesophagus	KYSE510	9.7
Oesophagus	KYSE520	9.3
Oesophagus	KYSE70	9.6
Oesophagus	OE19	8.6
Oesophagus	OE33	9
Oesophagus	TE10	8.9
Oesophagus	TE11	9.4
Oesophagus	TE14	9.6
Oesophagus	TE15	8.6
Oesophagus	TE1	8.4
Oesophagus	TE4	9.3
Oesophagus	TE5	9.2
Oesophagus	TE6	8.9
Oesophagus	TE8	10.1
Oesophagus	TE9	10.4
Oesophagus	TT	10.4
Ovary	59M	9.4
Ovary	A2780	10.1
Ovary	CAOV3	7.9
Ovary	CAOV4	9.5
Ovary	COLO704	9.8
Ovary	COV318	10.1
Ovary	COV362	7.5
Ovary	COV434	9.2
Ovary	COV504	8.7
Ovary	COV644	7.7
Ovary	EFO21	8.4
Ovary	EFO27	9.6
Ovary	ES2	8
Ovary	FUOV1	8.9
Ovary	HEYA8	7.5
Ovary	HS571T	9
Ovary	IGROV1	9.7
Ovary	JHOC5	9.5
Ovary	JHOM1	10
Ovary	JHOM2B	9.4
Ovary	JHOS2	7.9
Ovary	JHOS4	10
Ovary	KURAMOCHI	10.5
Ovary	MCAS	9
Ovary	NIHOVCAR3	10
Ovary	OAW28	9.2
Ovary	OAW42	8.8
Ovary	OC314	7.8
Ovary	OC316	7.1
Ovary	ONCODG1	10
Ovary	OV56	9.3
Ovary	OV7	8.6
Ovary	OV90	7.2
Ovary	OVCAR4	9.8
Ovary	OVCAR8	8.1
Ovary	OVISE	9.2
Ovary	OVK18	10.6
Ovary	OVKATE	8.5
Ovary	OVMANA	9.2
Ovary	OVSAHO	9.7
Ovary	OVTOKO	9.1
Ovary	RMGI	9.3
Ovary	RMUGS	10.2
Ovary	SKOV3	8.8
Ovary	SNU119	8.8
Ovary	SNU840	9.5
Ovary	SNU8	9.9
Ovary	TOV112D	9.7
Ovary	TOV21G	9
Ovary	TYKNU	8.4
Pancreas	ASPC1	9
Pancreas	BXPC3	8.5
Pancreas	CAPAN1	8.6
Pancreas	CAPAN2	9.2
Pancreas	CFPAC1	9.5
Pancreas	DANG	8.2
Pancreas	HPAC	9.5
Pancreas	HPAFII	9.1
Pancreas	HS766T	8.8
Pancreas	HUPT3	8.2
Pancreas	HUPT4	8.6
Pancreas	KCIMOH1	9
Pancreas	KLM1	9.5
Pancreas	KP2	9.6
Pancreas	KP3	8.2
Pancreas	KP4	9.1
Pancreas	L33	9.5
Pancreas	MIAPACA2	8.9
Pancreas	PANC0203	9.5
Pancreas	PANC0213	9.7
Pancreas	PANC0327	8.6
Pancreas	PANC0403	9.6
Pancreas	PANC0504	8.7
Pancreas	PANC0813	8.4
Pancreas	PANC1005	7.3
Pancreas	PANC1	9.2
Pancreas	PATU8902	5.7
Pancreas	PATU8988S	9.4
Pancreas	PATU8988T	8.2
Pancreas	PK1	7.8
Pancreas	PK45H	8.5
Pancreas	PK59	7.9
Pancreas	PL45	7.4
Pancreas	PSN1	9.7
Pancreas	QGP1	9.8
Pancreas	SNU213	9.6
Pancreas	SNU324	9.8
Pancreas	SNU410	8.6
Pancreas	SU8686	9.5
Pancreas	SUIT2	7.4
Pancreas	SW1990	7.3
Pancreas	T3M4	8.7
Pancreas	TCCPAN2	7.4
Pancreas	YAPC	8.8
Pleura	ACCMESO1	8.2
Pleura	DM3	9.2
Pleura	ISTMES1	8.6
Pleura	ISTMES2	8.2
Pleura	JL1	9.4
Pleura	MPP89	8.7
Pleura	MSTO211H	8.5
Pleura	NCIH2052	8
Pleura	NCIH2452	8.3
Pleura	NCIH28	6.5
Prostate	22RV1	7.4
Prostate	DU145	8.2
Prostate	LNCAPCLONEFGC	9.1
Prostate	MDAPCA2B	8.2
Prostate	NCIH660	9.2
Prostate	PC3	7.5
Prostate	VCAP	8.5
Salivary gland	A253	9.3
Salivary gland	YD15	8.5
Skin	A101D	8.7
Skin	A2058	8.3
Skin	A375	9.5
Skin	C32	9.3
Skin	CHL1	8.9
Skin	CJM	9.5
Skin	COLO679	7.9
Skin	COLO741	8.9
Skin	COLO783	9
Skin	COLO792	8.4
Skin	COLO800	8.8
Skin	COLO818	8.4
Skin	COLO829	9.9
Skin	COLO849	10
Skin	G361	8.7
Skin	GRM	9.2
Skin	HMCB	8.2
Skin	HS294T	9.1
Skin	HS600T	9.1
Skin	HS688AT	9.1
Skin	HS695T	8.9
Skin	HS839T	8.6
Skin	HS852T	8.6
Skin	HS895T	8.4
Skin	HS934T	8.7
Skin	HS936T	9.3
Skin	HS939T	8.6
Skin	HS940T	9.4
Skin	HS944T	8.6
Skin	HT144	8.5
Skin	IGR1	8.4
Skin	IGR37	8.6
Skin	IGR39	7.8
Skin	IPC298	8
Skin	K029AX	9.6
Skin	LOXIMVI	8.2
Skin	MALME3M	8
Skin	MDAMB435S	8
Skin	MELHO	7.6
Skin	MELJUSO	8.3
Skin	MEWO	8.9
Skin	RPMI7951	8.3
Skin	RVH421	9.1
Skin	SH4	9.3
Skin	SKMEL1	7.3
Skin	SKMEL24	8.6
Skin	SKMEL28	9
Skin	SKMEL2	8.8
Skin	SKMEL30	9.4
Skin	SKMEL31	8.5
Skin	SKMEL3	8.4
Skin	SKMEL5	9
Skin	UACC257	7.4
Skin	UACC62	9.3
Skin	WM115	8.5
Skin	WM1799	8.7
Skin	WM2664	8.4
Skin	WM793	9
Skin	WM88	10
Skin	WM983B	7.5
Small intestine	HUTU80	9.8
Soft tissue	A204	9.2
Soft tissue	G401	9.2
Soft tissue	G402	8.8
Soft tissue	GCT	8
Soft tissue	HS729	8.6
Soft tissue	HT1080	8.4
Soft tissue	KYM1	10
Soft tissue	MESSA	9.4
Soft tissue	RD	8.6
Soft tissue	RH30	4.6
Soft tissue	RH41	9.5
Soft tissue	RKN	9.1
Soft tissue	S117	9.4
Soft tissue	SJRH30	8.3
Soft tissue	SKLMS1	8
Soft tissue	SKUT1	9.4
Soft tissue	TE125T	8.7
Soft tissue	TE159T	8.7
Soft tissue	TE441T	9.1
Soft tissue	TE617T	8.9
Stomach	2313287	8.6
Stomach	AGS	9.5
Stomach	AZ521	9.6
Stomach	ECC10	10.5
Stomach	ECC12	9.8
Stomach	FU97	7.8
Stomach	GCIY	10
Stomach	GSS	9.3
Stomach	GSU	9.2
Stomach	HGC27	6.4
Stomach	HS746T	8.4
Stomach	HUG1N	8.7
Stomach	IM95	7.6
Stomach	KATOIII	7.2
Stomach	KE39	8.4
Stomach	LMSU	8.2
Stomach	MKN1	9.3
Stomach	MKN45	9.3
Stomach	MKN74	9.8
Stomach	MKN7	9
Stomach	NCCSTCK140	10.7
Stomach	NCIN87	9.6
Stomach	NUGC2	9.9
Stomach	NUGC3	9.6
Stomach	NUGC4	8.1
Stomach	OCUM1	8.7
Stomach	RERFGC1B	10.2
Stomach	SH10TC	8
Stomach	SNU16	8.6
Stomach	SNU1	7.1
Stomach	SNU216	9.7
Stomach	SNU520	8.2
Stomach	SNU5	6.1
Stomach	SNU601	9
Stomach	SNU620	7.8
Stomach	SNU668	8.7
Stomach	SNU719	8.7
Stomach	TGBC11TKB	9.4
Thyroid	8305C	8.9
Thyroid	8505C	7.8
Thyroid	BCPAP	9.8
Thyroid	BHT101	8.4
Thyroid	CAL62	8.6
Thyroid	CGTHW1	8.7
Thyroid	FTC133	8.6
Thyroid	FTC238	8.2
Thyroid	ML1	9.6
Thyroid	SW579	8
Thyroid	TT2609C02	8.7
Thyroid	TT	10.2
Upper aerodigestive tract	BHY	8.9
Upper aerodigestive tract	BICR16	9.2
Upper aerodigestive tract	BICR18	8.9
Upper aerodigestive tract	BICR22	10
Upper aerodigestive tract	BICR31	9.6
Upper aerodigestive tract	BICR56	10.7
Upper aerodigestive tract	BICR6	10.1
Upper aerodigestive tract	CAL27	9
Upper aerodigestive tract	CAL33	9.5
Upper aerodigestive tract	DETROIT562	8.1
Upper aerodigestive tract	FADU	8.8
Upper aerodigestive tract	HS840T	8.8
Upper aerodigestive tract	HSC2	9.4
Upper aerodigestive tract	HSC3	8.5
Upper aerodigestive tract	HSC4	10.5
Upper aerodigestive tract	PECAPJ15	9
Upper aerodigestive tract	PECAPJ34CLONEC12	9.1
Upper aerodigestive tract	PECAPJ41CLONED2	8.6
Upper aerodigestive tract	PECAPJ49	9.5
Upper aerodigestive tract	SCC15	9.8
Upper aerodigestive tract	SCC25	9.1
Upper aerodigestive tract	SCC4	9.7
Upper aerodigestive tract	SCC9	9.8
Upper aerodigestive tract	SNU1076	10
Upper aerodigestive tract	SNU1214	8.8
Upper aerodigestive tract	SNU46	8.1
Upper aerodigestive tract	SNU899	9.6
Upper aerodigestive tract	YD10B	10
Upper aerodigestive tract	YD38	9.4
Upper aerodigestive tract	YD8	10.2
Urinary tract	5637	8.7
Urinary tract	639V	8.5
Urinary tract	647V	10
Urinary tract	BC3C	8.1
Urinary tract	BFTC905	9.8
Urinary tract	CAL29	9.4
Urinary tract	HS172T	8.7
Urinary tract	HT1197	8.3
Urinary tract	HT1376	9.5
Urinary tract	J82	7.9
Urinary tract	JMSU1	8.7
Urinary tract	KMBC2	9.7
Urinary tract	KU1919	9.4
Urinary tract	RT11284	9.7
Urinary tract	RT112	9.4
Urinary tract	RT4	9.3
Urinary tract	SCABER	8.7
Urinary tract	SW1710	10.1
Urinary tract	SW780	10.2
Urinary tract	T24	8.2
Urinary tract	TCCSUP	9.4
Urinary tract	UMUC1	9.9
Urinary tract	UMUC3	7.7
Urinary tract	VMCUB1	9.7

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	9.1
Adrenal gland	9.5
Appendix	11.1
Bone marrow	17.5
Breast	19.5
Cerebral cortex	16.6
Cervix, uterine	24
Colon	13.7
Duodenum	7.9
Endometrium	29.4
Epididymis	16.2
Esophagus	21
Fallopian tube	19.4
Gallbladder	20.8
Heart muscle	3.9
Kidney	8.5
Liver	3.4
Lung	15
Lymph node	9.4
Ovary	20.5
Pancreas	2.4
Parathyroid gland	23.2
Placenta	25.9
Prostate	22.7
Rectum	15.3
Salivary gland	4.7
Seminal vesicle	14.8
Skeletal muscle	1.2
Skin	30.7
Small intestine	8.8
Smooth muscle	22.8
Spleen	12.1
Stomach	12.4
Testis	227.1
Thyroid gland	19
Tonsil	11.3
Urinary bladder	18.4

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
27635108	Overexpression	Colorectal Carcinoma	We report that 6 out of 18 (33%) CTAs tested (MAGEA3, OIP5, TTK, PLU1, DKKL1, and FBXO39) were significantly (p < 0.05) overexpressed in tumor tissue compared with healthy colon samples isolated from the same patients.
27246838	Overexpression	Glioma	In addition, RT-PCR, western blot analysis and immunohistochemical analysis were performed using glioma tissue samples and the results revealed that JARID1B expression increased according to the histological grade of glioma.
26917489	Overexpression	Triple-Negative Breast Carcinoma	Increased expression of KDM5B correlating with disease progression and poor clinical outcome in breast cancer was reversed by hsa-miR-448.
26911146	Overexpression	Hepatocellular Carcinoma	KDM5B is frequently up-regulated in HCC specimens compared with adjacent normal tissues and its expression level was significantly correlated with tumor size, TNM stage, and Edmondson grade.
26655717	Overexpression	Leukemia	In leukemia, JARID1B is overexpressed, and its inhibition results in cellular growth arrest.
26184998	Overexpression	Oral Squamous Cell Carcinoma	JARID1B overexpression is a dependent prognostic factor in OSCC patients.
26131109	Overexpression	Prostate Carcinoma	KDM5B was highly expressed in PCa cancer cells.
26125737	Overexpression	invasive ductal carcinoma	The positive staining rate of JARID1B/KDM5B and p16 protein in cancer tissue was 74.43 and 35.8%, respectively. JARID1B/KDM5B protein expression was positively associated with T grade, Bloom and Richardson (B&R) score and axillary lymph node metastasis (P < 0.05).
25909289	Overexpression	Hepatocellular Carcinoma	Here we show that JARID1B is elevated in HCC and its expression level is positively correlated with metastasis.
25877751	Overexpression	Lung Carcinoma	In present study, we found that JARID1B was overexpressed in lung cancer cell lines and lung cancer tissues but not in normal lung tissues.
25777981	Overexpression	HHead and Neck Squamous Cell Carcinoma	In the present study, we found that PLU-1/JARID1B mRNA was upregulated in all tested HNSCC cell lines.
25755704	Overexpression	mantle cell Lymphoma	We demonstrated that JARID1B was upregulated and histone tri-methylated H3K4 was downregulated in MCL compared to proliferative lymphadenitis, P < 0.05.
25663457	Overexpression	Ovarian Carcinoma	JARID1B level was significantly increased in EOC, as compared to normal ovaries and BOT.
25628922	Overexpression	Gastric Carcinoma	In clinical gastric cancer samples, we found that KDM5B expression was significantly up-regulated in cancer lesions compared with paired normal gastric tissues.
25450384	Overexpression	Glioma	In clinical glioma samples, we found that KDM5B expression was significantly upregulated in cancer lesions compared with normal brain tissues.
24937458	Overexpression (copy number gain)	Breast Neoplasm	Here, we show that JARID1B, encoding a histone H3 lysine 4 (H3K4) demethylase, is frequently amplified and overexpressed in luminal breast tumors and a somatic mutation in a basal-like breast cancer results in the gain of unique chromatin binding and luminal expression and splicing patterns.
23579952	Overexpression	Bladder Carcinoma	Connexin 26 (Cx26) expression is down-regulated and KDM5B (H3K4 demethylase) is up-regulated in the progression of bladder cancer, suggesting that Cx26 expression may be down-regulated by KDM5B in bladder cancer.
23408432	Overexpression	Breast Carcinoma; Prostate Carcinoma; Lung Carcinoma	JARID1B is overexpressed in several cancers, including breast cancer, prostate cancer, and lung cancer.
23262439	Overexpression	Melanoma	Contrary to earlier reports, this study shows enhanced expression of JARID1B by melanoma cells and indicates that such an enhancement may be an early event in the disease progression, is not correlated with melanoma invasiveness, and therefore may not be a suitable candidate as a prognostic marker.
22669717	Overexpression	Uveal Melanoma	This study demonstrates that JARID1B is expressed by UM cells. Despite that JARID1B was highly expressed in UM, a statistically significant association (P < 0.05) between JARID1B expression and OS could not be obtained.
22534467	Overexpression	Esophageal Squamous Cell Carcinoma	Our results showed that JARID1B and PHF2 were overexpressed in ESCCs.
22371483	Overexpression	Breast Carcinoma	Overexpression of all three proteins resulted in forced S-phase entry and attenuation of checkpoint activation, even in the presence of chemotherapy drugs. Since each protein has been linked to poor prognosis in breast cancer, our findings suggest that the TFAP2C-Myc-KDM5B complex promotes cell cycle progression via direct CDKN1A repression, thereby contributing to tumorigenesis and therapy failure.
22120715	Overexpression	Prostate Carcinoma	Our results show that the KDMs JARID1B, PHF8, KDM3A, KDM3B and KDM4A were highly expressed in clinical PrCa samples.
21369698	Overexpression	Breast Carcinoma	JARID1B is widely expressed in ER+ breast cancers and breast cancer cell lines, and interaction with ERα was demonstrated by co-immunoprecipitations in cells transfected with tagged ERα and JARID1B genes
20863814	Underexpression	Melanoma	Notably, both TIEG1 and JARID1B are downregulated in melanomas, suggesting that they indeed cooperate physiologically.
20726502	Overexpression	B cell malignancy; T cell malignancy	Our extensive analysis revealed multiple CT transcripts exhibiting widespread expression across cell lines derived from 21 B- and 4 T-cell malignancies. The broadest mRNA expression profiles were observed for the following eight CT genes: Sp17 (25/25), PRAME (25/25), CSAGE (24/25), PASD1 (22/25), CAGE/DDX53 (19/25), CTAGE1 (19/25), HAGE/DDX43 (16/25) and PLU-1/JARID1B (15/25).
20226085	Overexpression	Bladder Carcinoma	Quantitative RT-PCR analysis confirmed that expression levels of KDM5B are significantly higher in human bladder cancer tissues than in their corresponding non-neoplastic bladder tissues (P < 0.0001).
18048344	Overexpression	Prostate Carcinoma	Furthermore, we found that JARID1B is up-regulated in prostate cancer tissues, compared with benign prostate samples.
17973255	Loss of Expression	Melanoma	The RBP2-H1/JARID1B nuclear protein belongs to the ARID family of DNA-binding proteins and is a potential tumor suppressor that is lost during melanoma development.
15803180	Loss of Expression	Malignant melonoma	We conclude that loss of RBP2-H1 is a common finding in the progression of malignant melanomas.
12237901	Overexpression	Breast Carcinoma	The PLU-1 gene is expressed at the level of message in breast cancers and breast cancer cell lines and shows restricted expression in normal adult tissues with the exception of testis.
10336460	Overexpression	Breast Carcinoma	Although expression of PLU-1 in ce-1 cells is regulated by signaling from c-ErbB2, the gene is expressed in all the breast cancer cell lines examined, in cells cultured from primary breast cancers, and in the invasive and in situ components of primary breast cancers.
28492139	Overexpression	Osteosarcoma	In this study, we found that the expression levels of JARID1B in osteosarcoma tissues were significantly higher than those in corresponding noncancerous bone tissues.
28398479	Overexpression	Prostate Carcinoma	Higher KDM5B expression was observed in samples with methylated mir-155 or mir-137 promoters, whereas upregulation of KDM1A and DNMT1 was associated with mir-155 and mir-152 methylation status, respectively.
27480251	Overexpression	Esophageal Squamous Cell Carcinoma	We detected the expression of miR-194 and KDM5B by quantitative real-time reverse transcription PCR (qRT-PCR) and Western blot assays, respectively, and found down-regulation of miR-194 and up-regulation of KDM5B existed in esophageal squamous cell carcinoma cell lines.

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.312	1.46e-10	16.1	53.2	30.7	Neutral
BRCA	Breast invasive carcinoma	1075	0.555	6.06e-88	1.6	23	75.4	Gain
CESC	Cervical and endocervical cancers	292	0.315	3.67e-08	2.4	46.6	51	Gain
COAD	Colon adenocarcinoma	449	0.436	2.62e-22	9.8	68.4	21.8	Neutral
ESCA	Esophageal carcinoma	183	0.448	1.99e-10	12	42.1	45.9	Gain
GBM	Glioblastoma multiforme	147	0.47	1.84e-09	2.7	77.6	19.7	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.189	1.55e-05	7	66.1	26.8	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.288	1.73e-11	6.5	82.7	10.9	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.341	2.87e-09	6.9	86.8	6.2	Neutral
LAML	Acute Myeloid Leukemia	166	0.101	0.197	0	98.2	1.8	Neutral
LGG	Brain Lower Grade Glioma	513	0.205	2.97e-06	3.5	89.9	6.6	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.486	5.48e-23	1.6	25.3	73.1	Gain
LUAD	Lung adenocarcinoma	512	0.549	1.29e-41	3.1	26	70.9	Gain
LUSC	Lung squamous cell carcinoma	498	0.277	3.17e-10	5.4	44.6	50	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.591	1.12e-29	8	41	51	Gain
PAAD	Pancreatic adenocarcinoma	177	0.511	3.65e-13	4.5	65.5	29.9	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.365	1.8e-06	8.6	75.3	16	Neutral
PRAD	Prostate adenocarcinoma	491	0.262	3.59e-09	1	92.9	6.1	Neutral
READ	Rectum adenocarcinoma	164	0.584	2.22e-16	11	61	28	Neutral
SARC	Sarcoma	255	0.371	9.15e-10	25.1	54.5	20.4	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.611	5.45e-39	4.4	40.6	55	Gain
STAD	Stomach adenocarcinoma	413	0.42	4.27e-19	4.8	65.6	29.5	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.228	0.00498	2	51.3	46.7	Gain
THCA	Thyroid carcinoma	497	0.367	2.48e-17	0.6	93.8	5.6	Neutral
THYM	Thymoma	119	0.24	0.00865	0	79	21	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.525	2.03e-39	2.8	54.9	42.3	Gain

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.158	0.00106	17	408	-0.001	0.0534	NS/NA
BRCA	Breast invasive carcinoma	-0.255	3.02e-14	83	785	-0.001	2.55e-06	NS/NA
CESC	Cervical and endocervical cancers	-0.182	0.00134	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.152	0.00699	19	297	0.001	0.0182	NS/NA
ESCA	Esophageal carcinoma	-0.185	0.01	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.203	0.104	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.157	0.000247	20	522	0	0.0389	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.128	0.0174	24	319	0.119	0.00168	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.156	0.00719	23	275	0.005	1.32e-07	NS/NA
LAML	Acute Myeloid Leukemia	0.008	0.92	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.078	0.073	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.239	9.39e-07	41	373	-0.002	0.139	NS/NA
LUAD	Lung adenocarcinoma	-0.068	0.14	21	456	0.006	0.0147	NS/NA
LUSC	Lung squamous cell carcinoma	-0.124	0.016	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.483	0.194	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.015	0.845	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.13	0.077	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.072	0.0955	35	498	-0.007	4.11e-05	NS/NA
READ	Rectum adenocarcinoma	-0.289	0.00345	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.27	9.58e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.224	9.77e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.275	8.38e-08	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.468	1.11e-09	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.08	0.0592	50	509	0.174	1.93e-07	NS/NA
THYM	Thymoma	-0.246	0.00649	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.216	2.8e-06	34	431	-0.007	0.00244	NS/NA

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	1	Low
Bone marrow	1	Low
Breast	1	Low
Bronchus	1	Low
Caudate	0	Not detected
Cerebellum	0	Not detected
Cerebral cortex	1	Low
Cervix, uterine	1	Low
Colon	1	Low
Duodenum	1	Low
Endometrium	1	Low
Epididymis	2	Medium
Esophagus	1	Low
Fallopian tube	1	Low
Gallbladder	1	Low
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	1	Low
Liver	1	Low
Lung	1	Low
Lymph node	0	Not detected
Nasopharynx	1	Low
Oral mucosa	1	Low
Ovary	1	Low
Pancreas	1	Low
Parathyroid gland	1	Low
Placenta	1	Low
Prostate	0	Not detected
Rectum	1	Low
Salivary gland	1	Low
Seminal vesicle	1	Low
Skeletal muscle	0	Not detected
Skin	1	Low
Small intestine	1	Low
Smooth muscle	1	Low
Soft tissue	1	Low
Spleen	0	Not detected
Stomach	1	Low
Testis	3	High
Thyroid gland	1	Low
Tonsil	1	Low
Urinary bladder	1	Low
Vagina	1	Low

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.077	NS	24476821
BRCA	Breast invasive carcinoma	521	0.000176	Significant	23000897
COAD	Colon adenocarcinoma	149	0.425	NS	22810696
GBM	Glioblastoma multiforme	157	4.01e-09	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.26e-09	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.62	NS	26536169
LGG	Brain Lower Grade Glioma	513	1.05e-18	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.0207	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0253	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	1e-08	Significant	21720365
PRAD	Prostate adenocarcinoma	333	1.04e-09	Significant	26544944
READ	Rectum adenocarcinoma	67	0.828	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.000338	Significant	26091043
STAD	Stomach adenocarcinoma	277	3.37e-05	Significant	25079317
THCA	Thyroid carcinoma	391	2.1e-27	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.305	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.996	0.982	NS
BRCA	Breast invasive carcinoma	1079	1.404	0.15	NS
CESC	Cervical and endocervical cancers	291	1.646	0.185	NS
COAD	Colon adenocarcinoma	439	1.103	0.732	NS
ESCA	Esophageal carcinoma	184	0.979	0.951	NS
GBM	Glioblastoma multiforme	158	0.67	0.11	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.035	0.859	NS
KIRC	Kidney renal clear cell carcinoma	531	0.734	0.157	NS
KIRP	Kidney renal papillary cell carcinoma	287	1.833	0.115	NS
LAML	Acute Myeloid Leukemia	149	0.37	0.00151	Longer
LGG	Brain Lower Grade Glioma	511	0.477	0.00148	Longer
LIHC	Liver hepatocellular carcinoma	365	1.694	0.043	Shorter
LUAD	Lung adenocarcinoma	502	1.339	0.183	NS
LUSC	Lung squamous cell carcinoma	494	0.905	0.601	NS
OV	Ovarian serous cystadenocarcinoma	303	1.314	0.214	NS
PAAD	Pancreatic adenocarcinoma	177	1.533	0.169	NS
PCPG	Pheochromocytoma and Paraganglioma	179	591577672.136	0.0186	Shorter
PRAD	Prostate adenocarcinoma	497	505428498.351	0.114	NS
READ	Rectum adenocarcinoma	159	0.648	0.418	NS
SARC	Sarcoma	259	1.099	0.74	NS
SKCM	Skin Cutaneous Melanoma	459	1.263	0.217	NS
STAD	Stomach adenocarcinoma	388	1.236	0.356	NS
TGCT	Testicular Germ Cell Tumors	134	0.507	0.571	NS
THCA	Thyroid carcinoma	500	1.426	0.616	NS
THYM	Thymoma	119	0.344	0.217	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.511	0.19	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.03	0.546	NS
BRCA	Breast invasive carcinoma	1071	0.034	0.268	NS
CESC	Cervical and endocervical cancers	167	0.129	0.0963	NS
COAD	Colon adenocarcinoma	445	0.06	0.206	NS
ESCA	Esophageal carcinoma	162	-0.081	0.304	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.042	0.37	NS
KIRC	Kidney renal clear cell carcinoma	531	-0.096	0.0264	Lower
KIRP	Kidney renal papillary cell carcinoma	260	0.114	0.0677	NS
LIHC	Liver hepatocellular carcinoma	347	0.083	0.125	NS
LUAD	Lung adenocarcinoma	507	-0.001	0.977	NS
LUSC	Lung squamous cell carcinoma	497	-0.1	0.0255	Lower
OV	Ovarian serous cystadenocarcinoma	302	-0.116	0.0449	Lower
PAAD	Pancreatic adenocarcinoma	176	0.238	0.0015	Higher
READ	Rectum adenocarcinoma	156	0.044	0.589	NS
SKCM	Skin Cutaneous Melanoma	410	-0.024	0.628	NS
STAD	Stomach adenocarcinoma	392	0.081	0.111	NS
TGCT	Testicular Germ Cell Tumors	81	-0.073	0.517	NS
THCA	Thyroid carcinoma	499	0.081	0.0698	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.062	0.168	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.054	0.375	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.247	2.2e-08	Lower
KIRC	Kidney renal clear cell carcinoma	525	-0.084	0.0558	NS
LGG	Brain Lower Grade Glioma	514	-0.017	0.702	NS
LIHC	Liver hepatocellular carcinoma	366	0.084	0.108	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.084	0.15	NS
PAAD	Pancreatic adenocarcinoma	176	0.192	0.0106	Higher
STAD	Stomach adenocarcinoma	406	-0.175	0.000395	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.043	0.318	NS

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for KDM5B.

Summary
Symbol	KDM5B
Name	lysine demethylase 5B
Aliases	RBBP2H1A; PLU-1; CT31; PPP1R98; cancer/testis antigen 31; protein phosphatase 1, regulatory subunit 98; JARI ......
Location	1q32.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26917489	Triple-Negative Breast Carcinoma	upstream	has-miR-448	Negative regulation	Our findings demonstrate the critical role of KDM5B and its negative regulator hsa-miR-448 in TNBC metastasis and progression. Hsa-miR-448 disrupting KDM5B-MALAT1 signalling axis and associated activities in TNBC cells, projects it as a putative therapeutic factor for selective eradication of TNBC cells.
26911146	Hepatocellular Carcinoma	downstream	p15; p27	negative regulation	Knockdown of KDM5B notably inhibits HCC cell proliferation both in vivo and in vitro via arresting the cell cycle at G1/S phase partly through up-regulation of p15 and p27.
26655717	Leukemia	upstream	Ikaros-HDAC1 complex	Negative regulation	Ikaros-mediated repression of JARID1B in leukemia is impaired by pro-oncogenic casein kinase 2 (CK2). Inhibition of CK2 results in increased binding of the Ikaros-HDAC1 complex to the promoter of JARID1B, with increased formation of trimethylated histone H3 lysine 27 and decreased histone H3 Lys-9 acetylation.
26131109	Prostate Carcinoma	upstream	miR29a	Negative regulation	Moreover, the enforced expression of miR-29a in PC-3 and LNCaP cells inhibited proliferation, and induced apoptosis by repressing the expression of KDM5B.
26125737	invasive ductal carcinoma	partner	p16	Negative correlation	JARID1B/KDM5B and p16 protein expression in breast cancer and adjacent normal breast tissue were negatively correlated (r = -0.303, P < 0.001).
25909289	Hepatocellular Carcinoma	downstream	PTEN	negative regulation	Mechanistically, we found JARID1B exerts its function through modulation of H3K4me3 at the PTEN gene promoter, which was associated with inactive PTEN transcription. PTEN overexpression blocked JARID1B-driven proliferation, EMT, and metastasis.
25877751	Lung Carcinoma	downstream	p53	Negative regulation	Overexpressed JARID1B cell exhibited greatly decreased p53 expression, whereas silencing of JARID1B expression dramatically increased p53 expression at both the messenger RNA (mRNA) and protein levels.
25777981	HHead and Neck Squamous Cell Carcinoma	partner	Ki-67	Positive correlation	A positive association was observed between high PLU-1/JARID1B expression and higher Ki-67 labeling in the HNSCC samples (Pearson r=0.6514, P=0.0003).
25755704	mantle cell Lymphoma	downstream	Cyclin D1	Positive regulation	Interestingly, depletion of JARID1B inhibits Cyclin D1, which is one of the genes contributes to MCL pathogenesis.
23579952	Bladder Carcinoma	downstream	Cx26	Negative regulation	Connexin 26 (Cx26) expression is down-regulated and KDM5B (H3K4 demethylase) is up-regulated in the progression of bladder cancer, suggesting that Cx26 expression may be down-regulated by KDM5B in bladder cancer.
22371483	Breast Carcinoma	partner	TFAP2C; Myc	Binding	Overexpression of all three proteins resulted in forced S-phase entry and attenuation of checkpoint activation, even in the presence of chemotherapy drugs. Since each protein has been linked to poor prognosis in breast cancer, our findings suggest that the TFAP2C-Myc-KDM5B complex promotes cell cycle progression via direct CDKN1A repression, thereby contributing to tumorigenesis and therapy failure.
22371483	Breast Carcinoma	downstream	CDKN1A	Negative regulation	Overexpression of all three proteins resulted in forced S-phase entry and attenuation of checkpoint activation, even in the presence of chemotherapy drugs. Since each protein has been linked to poor prognosis in breast cancer, our findings suggest that the TFAP2C-Myc-KDM5B complex promotes cell cycle progression via direct CDKN1A repression, thereby contributing to tumorigenesis and therapy failure.
20863814	Melanoma	partner	TIEG1	Collaboration	Thus, TIEG1 and JARID1B may cooperate to suppress tumorigenesis by enhancing TGF-β signaling.
20863814	Melanoma	downstream	Smad7; TGF-β signaling	Negative regulation	Conversely, JARID1B knock-down leads to increased Smad7 mRNA levels. Thus, TIEG1 and JARID1B may cooperate to suppress tumorigenesis by enhancing TGF-β signaling.
20226085	Bladder Carcinoma	downstream	E2F1; E2F2	Regulation	Microarray expression analysis indicated that E2F1 and E2F2 are downstream genes in the KDM5B pathway.
18048344	Prostate Carcinoma	downstream	AR	regulation	We also demonstrated that JARID1B associates with androgen receptor and regulates its transcriptional activity.
15803180	Malignant melonoma	partner	pRb	Collaboration	Since a direct interaction of RBP2-H1 and pRb seems possible, the loss of RBP2-H1 may possibly contribute to uncontrolled growth in malignant melanomas.
10336460	Breast Carcinoma	upstream	c-ErbB2	regulation	Although expression of PLU-1 in ce-1 cells is regulated by signaling from c-ErbB2, the gene is expressed in all the breast cancer cell lines examined, in cells cultured from primary breast cancers, and in the invasive and in situ components of primary breast cancers.
28492139	Osteosarcoma	downstream	Cyclin D1	Regulation	We further demonstrated that JARID1B regulates Cyclin D1 expression through H3K27me3.
27480251	Esophageal Squamous Cell Carcinoma	upstream	miR-194	Negative regulation	We detected the expression of miR-194 and KDM5B by quantitative real-time reverse transcription PCR (qRT-PCR) and Western blot assays, respectively, and found down-regulation of miR-194 and up-regulation of KDM5B existed in esophageal squamous cell carcinoma cell lines. miR-194 was further verified to regulate proliferation, apoptosis and invasion of esophageal squamous cell carcinoma cells by directly targeting KDM5B.