CR2Cancer

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF00038 Intermediate filament protein
PF00932 Lamin Tail Domain

Function

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.; FUNCTION: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Classification

Class	Modification	Substrate	Product	PubMed
#	#	#	#	#

> Gene Ontology [ TOP ]
Biological Process	GO:0000226 microtubule cytoskeleton organization GO:0001666 response to hypoxia GO:0001836 release of cytochrome c from mitochondria GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0006991 response to sterol depletion GO:0006997 nucleus organization GO:0006998 nuclear envelope organization GO:0007077 mitotic nuclear envelope disassembly GO:0007084 mitotic nuclear envelope reassembly GO:0007163 establishment or maintenance of cell polarity GO:0007507 heart development GO:0007568 aging GO:0007569 cell aging GO:0008637 apoptotic mitochondrial changes GO:0010463 mesenchymal cell proliferation GO:0010464 regulation of mesenchymal cell proliferation GO:0010639 negative regulation of organelle organization GO:0010821 regulation of mitochondrion organization GO:0010823 negative regulation of mitochondrion organization GO:0014706 striated muscle tissue development GO:0017038 protein import GO:0030397 membrane disassembly GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity GO:0030952 establishment or maintenance of cytoskeleton polarity GO:0030968 endoplasmic reticulum unfolded protein response GO:0031468 nuclear envelope reassembly GO:0032933 SREBP signaling pathway GO:0034504 protein localization to nucleus GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035051 cardiocyte differentiation GO:0035105 sterol regulatory element binding protein import into nucleus GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0036498 IRE1-mediated unfolded protein response GO:0042692 muscle cell differentiation GO:0044744 protein targeting to nucleus GO:0048738 cardiac muscle tissue development GO:0051081 nuclear envelope disassembly GO:0051146 striated muscle cell differentiation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055006 cardiac cell development GO:0055007 cardiac muscle cell differentiation GO:0055012 ventricular cardiac muscle cell differentiation GO:0055013 cardiac muscle cell development GO:0055015 ventricular cardiac muscle cell development GO:0060537 muscle tissue development GO:0070482 response to oxygen levels GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071501 cellular response to sterol depletion GO:0072201 negative regulation of mesenchymal cell proliferation GO:0090199 regulation of release of cytochrome c from mitochondria GO:0090201 negative regulation of release of cytochrome c from mitochondria GO:0090342 regulation of cell aging GO:0090343 positive regulation of cell aging GO:0097191 extrinsic apoptotic signaling pathway GO:1900180 regulation of protein localization to nucleus GO:1902593 single-organism nuclear import GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Molecular Function	-
Cellular Component	GO:0005635 nuclear envelope GO:0005638 lamin filament GO:0005652 nuclear lamina GO:0005882 intermediate filament GO:0016604 nuclear body GO:0016607 nuclear speck GO:0031965 nuclear membrane GO:0034399 nuclear periphery GO:0045111 intermediate filament cytoskeleton

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04210 Apoptosis
Reactome	R-HSA-109581: Apoptosis R-HSA-111465: Apoptotic cleavage of cellular proteins R-HSA-75153: Apoptotic execution phase R-HSA-352238: Breakdown of the nuclear lamina R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-4419969: Depolymerisation of the Nuclear Lamina R-HSA-8862803: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-381070: IRE1alpha activates chaperones R-HSA-2995383: Initiation of Nuclear Envelope Reformation R-HSA-68886: M Phase R-HSA-1500620: Meiosis R-HSA-1221632: Meiotic synapsis R-HSA-392499: Metabolism of proteins R-HSA-68882: Mitotic Anaphase R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-68875: Mitotic Prophase R-HSA-8863678: Neurodegenerative Diseases R-HSA-2980766: Nuclear Envelope Breakdown R-HSA-2995410: Nuclear Envelope Reassembly R-HSA-6802957: Oncogenic MAPK signaling R-HSA-5357801: Programmed Cell Death R-HSA-6802952: Signaling by BRAF and RAF fusions R-HSA-381119: Unfolded Protein Response (UPR) R-HSA-381038: XBP1(S) activates chaperone genes

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04210 Apoptosis

Reactome

R-HSA-109581: Apoptosis
R-HSA-111465: Apoptotic cleavage of cellular proteins
R-HSA-75153: Apoptotic execution phase
R-HSA-352238: Breakdown of the nuclear lamina
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-4419969: Depolymerisation of the Nuclear Lamina
R-HSA-8862803: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-381070: IRE1alpha activates chaperones
R-HSA-2995383: Initiation of Nuclear Envelope Reformation
R-HSA-68886: M Phase
R-HSA-1500620: Meiosis
R-HSA-1221632: Meiotic synapsis
R-HSA-392499: Metabolism of proteins
R-HSA-68882: Mitotic Anaphase
R-HSA-2555396: Mitotic Metaphase and Anaphase
R-HSA-68875: Mitotic Prophase
R-HSA-8863678: Neurodegenerative Diseases
R-HSA-2980766: Nuclear Envelope Breakdown
R-HSA-2995410: Nuclear Envelope Reassembly
R-HSA-6802957: Oncogenic MAPK signaling
R-HSA-5357801: Programmed Cell Death
R-HSA-6802952: Signaling by BRAF and RAF fusions
R-HSA-381119: Unfolded Protein Response (UPR)
R-HSA-381038: XBP1(S) activates chaperone genes

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM162181	c.814G>T	p.D272Y	Substitution - Missense	Breast
COSM897117	c.748G>A	p.A250T	Substitution - Missense	Endometrium
COSM1668050	c.1901G>T	p.G634V	Substitution - Missense	Large_intestine
COSM1668050	c.1901G>T	p.G634V	Substitution - Missense	Large_intestine
COSM1213486	c.752A>G	p.Q251R	Substitution - Missense	Large_intestine
COSM3475153	c.688G>T	p.D230Y	Substitution - Missense	Skin
COSM5729249	c.1052G>A	p.R351K	Substitution - Missense	Skin
COSM3802186	c.250G>A	p.E84K	Substitution - Missense	Breast
COSM3475155	c.906C>T	p.L302L	Substitution - coding silent	Skin
COSM5613773	c.1129C>T	p.R377C	Substitution - Missense	Lung
COSM1213485	c.1027C>T	p.R343W	Substitution - Missense	Large_intestine
COSM4458910	c.1104C>T	p.A368A	Substitution - coding silent	Skin
COSM1559931	c.1487C>T	p.T496M	Substitution - Missense	Large_intestine
COSM5557701	c.465G>T	p.K155N	Substitution - Missense	Prostate
COSM5052637	c.1016C>T	p.A339V	Substitution - Missense	Stomach
COSM897122	c.1930C>T	p.R644C	Substitution - Missense	Endometrium
COSM5832322	c.1786delG	p.D596fs*>69	Deletion - Frameshift	Breast
COSM3475157	c.961C>T	p.R321*	Substitution - Nonsense	Skin
COSM3788810	c.954G>A	p.A318A	Substitution - coding silent	Urinary_tract
COSM4763037	c.188T>C	p.I63T	Substitution - Missense	Stomach
COSM4698221	c.812T>C	p.L271P	Substitution - Missense	Large_intestine
COSM3802187	c.1700G>T	p.G567V	Substitution - Missense	Breast
COSM4985024	c.1338T>C	p.D446D	Substitution - coding silent	Soft_tissue
COSM5495572	c.795G>A	p.K265K	Substitution - coding silent	Biliary_tract
COSM897115	c.265C>A	p.R89S	Substitution - Missense	Endometrium
COSM1983026	c.1300G>A	p.A434T	Substitution - Missense	Large_intestine
COSM5483594	c.1729G>A	p.A577T	Substitution - Missense	Large_intestine
COSM5914688	c.1208C>T	p.S403F	Substitution - Missense	Skin
COSM4887568	c.1163G>T	p.R388L	Substitution - Missense	Upper_aerodigestive_tract
COSM4985024	c.1338T>C	p.D446D	Substitution - coding silent	Soft_tissue
COSM1668049	c.1147G>A	p.E383K	Substitution - Missense	Large_intestine
COSM1295217	c.406G>A	p.D136N	Substitution - Missense	Urinary_tract
COSM4460567	c.1170C>T	p.S390S	Substitution - coding silent	Skin
COSM4466383	c.1431C>T	p.P477P	Substitution - coding silent	Skin
COSM4985024	c.1338T>C	p.D446D	Substitution - coding silent	Soft_tissue
COSM5735667	c.1550A>G	p.Q517R	Substitution - Missense	Small_intestine
COSM3475163	c.1209C>T	p.S403S	Substitution - coding silent	Skin
COSM4763038	c.727G>A	p.D243N	Substitution - Missense	Stomach
COSM675676	c.887G>A	p.R296H	Substitution - Missense	Lung
COSM4698228	c.1752C>T	p.R584R	Substitution - coding silent	Large_intestine
COSM3984309	c.918C>T	p.L306L	Substitution - coding silent	Kidney
COSM1983007	c.832G>C	p.A278P	Substitution - Missense	Thyroid
COSM675677	c.216C>A	p.R72R	Substitution - coding silent	Lung
COSM4473205	c.1835C>T	p.S612F	Substitution - Missense	Skin
COSM463140	c.1444C>T	p.R482W	Substitution - Missense	Small_intestine
COSM463140	c.1444C>T	p.R482W	Substitution - Missense	Large_intestine
COSM5808832	c.91G>A	p.E31K	Substitution - Missense	Liver
COSM3750412	c.1698C>T	p.H566H	Substitution - coding silent	Breast
COSM4222583	c.1870C>T	p.R624C	Substitution - Missense	Large_intestine
COSM463140	c.1444C>T	p.R482W	Substitution - Missense	Kidney
COSM3475165	c.1765G>C	p.G589R	Substitution - Missense	Skin
COSM4620299	c.24C>T	p.R8R	Substitution - coding silent	Large_intestine
COSM162181	c.814G>T	p.D272Y	Substitution - Missense	Breast
COSM5652272	c.712G>A	p.E238K	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM5758052	c.690C>T	p.D230D	Substitution - coding silent	Bone
COSM4593170	c.1691A>C	p.H564P	Substitution - Missense	Upper_aerodigestive_tract
COSM897118	c.991C>T	p.R331W	Substitution - Missense	Endometrium
COSM4481296	c.249C>T	p.A83A	Substitution - coding silent	Skin
COSM3750412	c.1698C>T	p.H566H	Substitution - coding silent	Thyroid
COSM675676	c.887G>A	p.R296H	Substitution - Missense	Endometrium
COSM4877454	c.985C>T	p.R329C	Substitution - Missense	Prostate
COSM897120	c.1201C>T	p.R401C	Substitution - Missense	Stomach
COSM117035	c.1740C>A	p.N580K	Substitution - Missense	Ovary
COSM897120	c.1201C>T	p.R401C	Substitution - Missense	Bone
COSM4918617	c.357-2A>G	p.?	Unknown	Liver
COSM5643908	c.703C>T	p.R235C	Substitution - Missense	Oesophagus
COSM3475150	c.80C>T	p.T27I	Substitution - Missense	Skin
COSM1668049	c.1147G>A	p.E383K	Substitution - Missense	Large_intestine
COSM1983026	c.1300G>A	p.A434T	Substitution - Missense	Prostate
COSM3750412	c.1698C>T	p.H566H	Substitution - coding silent	Breast
COSM3984311	c.1638A>C	p.S546S	Substitution - coding silent	Kidney
COSM5910191	c.937-3C>T	p.?	Unknown	Skin
COSM1668050	c.1901G>T	p.G634V	Substitution - Missense	Large_intestine
COSM5566053	c.1303C>T	p.R435C	Substitution - Missense	Prostate
COSM4698229	c.1785C>T	p.A595A	Substitution - coding silent	Large_intestine
COSM3705073	c.672C>T	p.T224T	Substitution - coding silent	Liver
COSM1983026	c.1300G>A	p.A434T	Substitution - Missense	Large_intestine
COSM1472743	c.569G>A	p.R190Q	Substitution - Missense	Breast
COSM1668048	c.892C>T	p.R298C	Substitution - Missense	Large_intestine
COSM4142808	c.232A>G	p.K78E	Substitution - Missense	Thyroid
COSM4698225	c.1123G>A	p.A375T	Substitution - Missense	Large_intestine
COSM4698230	c.1820T>C	p.V607A	Substitution - Missense	Large_intestine
COSM5930594	c.357-6C>T	p.?	Unknown	Skin
COSM897121	c.1699G>T	p.G567C	Substitution - Missense	Endometrium
COSM1668049	c.1147G>A	p.E383K	Substitution - Missense	Large_intestine
COSM5518201	c.1656C>T	p.D552D	Substitution - coding silent	Biliary_tract
COSM3360388	c.927C>G	p.L309L	Substitution - coding silent	Kidney
COSM5557431	c.1989C>A	p.I663I	Substitution - coding silent	Prostate
COSM4023184	c.1412G>A	p.R471H	Substitution - Missense	Stomach
COSM3965874	c.728A>G	p.D243G	Substitution - Missense	Central_nervous_system
COSM1668049	c.1147G>A	p.E383K	Substitution - Missense	Large_intestine
COSM1668050	c.1901G>T	p.G634V	Substitution - Missense	Large_intestine
COSM5777380	c.973G>A	p.D325N	Substitution - Missense	Breast
COSM3750412	c.1698C>T	p.H566H	Substitution - coding silent	Large_intestine
COSM4023190	c.1891G>A	p.G631S	Substitution - Missense	Stomach
COSM3934134	c.1067T>A	p.L356Q	Substitution - Missense	Oesophagus
COSM4698223	c.886C>T	p.R296C	Substitution - Missense	Large_intestine
COSM4023188	c.1748C>T	p.S583L	Substitution - Missense	Stomach
COSM5578883	c.1976A>T	p.Q659L	Substitution - Missense	Skin
COSM4641497	c.1929C>T	p.T643T	Substitution - coding silent	Large_intestine
COSM4651967	c.1975C>T	p.Q659*	Substitution - Nonsense	Large_intestine
COSM1559931	c.1487C>T	p.T496M	Substitution - Missense	Large_intestine
COSM3475161	c.1049C>T	p.A350V	Substitution - Missense	Skin
COSM252581	c.811-3C>A	p.?	Unknown	Ovary
COSM4475323	c.197C>T	p.S66F	Substitution - Missense	Skin
COSM4698227	c.1718C>T	p.S573L	Substitution - Missense	Large_intestine
COSM1295218	c.456C>G	p.L152L	Substitution - coding silent	Urinary_tract
COSM5887590	c.1720G>A	p.G574R	Substitution - Missense	Upper_aerodigestive_tract
COSM75246	c.628A>G	p.I210V	Substitution - Missense	Ovary
COSM5565983	c.1256G>A	p.R419H	Substitution - Missense	Prostate
COSM1982996	c.181C>A	p.L61I	Substitution - Missense	Large_intestine
COSM4023189	c.1871G>A	p.R624H	Substitution - Missense	Stomach
COSM4472937	c.1815C>T	p.A605A	Substitution - coding silent	Skin
COSM897120	c.1201C>T	p.R401C	Substitution - Missense	Endometrium
COSM897119	c.1184C>T	p.S395L	Substitution - Missense	Endometrium
COSM4023186	c.1488+2T>G	p.?	Unknown	Stomach
COSM1983008	c.858G>A	p.G286G	Substitution - coding silent	Stomach
COSM5459885	c.1663G>T	p.D555Y	Substitution - Missense	Large_intestine
COSM4466982	c.1464C>T	p.T488T	Substitution - coding silent	Skin
COSM3705073	c.672C>T	p.T224T	Substitution - coding silent	Liver
COSM1733440	c.356+2T>C	p.?	Unknown	Pancreas
COSM5777380	c.973G>A	p.D325N	Substitution - Missense	Breast
COSM4933592	c.1905C>T	p.G635G	Substitution - coding silent	Liver
COSM3475151	c.205G>A	p.V69M	Substitution - Missense	Skin
COSM4985024	c.1338T>C	p.D446D	Substitution - coding silent	Soft_tissue
COSM4887076	c.1907G>T	p.S636I	Substitution - Missense	Upper_aerodigestive_tract
COSM4593170	c.1691A>C	p.H564P	Substitution - Missense	Upper_aerodigestive_tract
COSM3475152	c.312G>A	p.L104L	Substitution - coding silent	Skin
COSM3475159	c.984C>T	p.A328A	Substitution - coding silent	Skin
COSM75247	c.767T>G	p.V256G	Substitution - Missense	Ovary

> Text Mining based Variations

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PMID	Variation	Cancer	Evidence
26863915	Mutation	paediatric haemangiopericytoma-like sarcoma	Following detection of a LMNA-NTRK1 gene fusion in an index case of paediatric haemangiopericytoma-like sarcoma by combined whole-genome and RNA sequencing, we identified three additional sarcomas harbouring NTRK1 gene fusions, termed 'spindle cell sarcoma, NOS with myo/haemangiopericytic growth pattern'.
26716414	Mutation	Colon Carcinoma	Here we identified recurrent LMNA-NTRK1 and TPM3-NTRK1 fusions in Korean patients with colon cancer (3 out of 147, 2%) through next-generation RNA sequencing (RNA-seq).
26563355	Mutation	Colon Carcinoma	Molecular characterization unveiled a novel LMNA-NTRK1 rearrangement within chromosome 1 with oncogenic potential, and the patient was treated with the pan-TRK inhibitor entrectinib, achieving partial response with decrease in hepatic target lesions from 6.8 and 8.2cm in longest diameter to 4.7 and 4.3cm, respectively.
26546295	Mutation	Colorectal Carcinoma	A patient with metastatic colorectal cancer harboring an LMNA-NTRK1 rearrangement displayed a remarkable response to treatment with entrectinib, which was followed by the emergence of resistance.
26216294	Mutation	soft-tissue sarcoma metastatic to the lung	The tumor of a 41-year-old woman with soft-tissue sarcoma metastatic to the lung was found to harbor an LMNA-NTRK1 gene fusion encoding a functional LMNA-TRKA fusion oncoprotein as determined by an in situ proximity ligation assay.
16518869	Mutation	Colon Carcinoma	The study investigated the molecular basis of resveratrol (RSV)-evoked apoptosis in four (Bax+/-, Bax-/-, p53+/+, and p53-/-) HCT116 colon cancer cell lines. RSV induced apoptosis in all the cells in a dose-dependent manner; however, Bax+/- and p53+/+ cells were more susceptible than their knockout counterparts (Bax-/- and p53-/-, respectively). Using Bax+/- cells as a model, proteomic analysis revealed four RSV-responsive events: fragmentation of lamin A/C protein; increase in concentration of a more basic isoelectric variant of the ribosomal protein P0; and decrease in concentration of dUTPase as well as stathmin 1.
28683589	Mutation	Mesenchymal Cell Neoplasm	Using next-generation DNA sequencing, TMP3-NTRK1 fusions were identified in 4 cases, an LMNA-NTRK1 fusion in one case, and a variant EML4-NTRK3 fusion in one case.

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
P02545	3	T	Phosphothreonine	-	No	None detected
P02545	12	S	Phosphoserine	-	No	None detected
P02545	18	S	Phosphoserine	-	No	None detected
P02545	19	T	Phosphothreonine	-	No	None detected
P02545	22	S	Phosphoserine	-	No	None detected
P02545	32	K	N6-acetyllysine	-	Yes	p.K32del (cancer: ESCA)
P02545	32	K	N6-succinyllysine	-	Yes	p.K32del (cancer: ESCA)
P02545	51	S	Phosphoserine	-	No	None detected
P02545	66	S	Phosphoserine	-	No	None detected
P02545	71	S	Phosphoserine	-	No	None detected
P02545	107	S	Phosphoserine	-	No	None detected
P02545	108	K	N6-acetyllysine	-	No	None detected
P02545	123	K	N6-acetyllysine	-	No	None detected
P02545	135	K	N6-acetyllysine	-	No	None detected
P02545	155	K	N6-acetyllysine	-	No	None detected
P02545	171	K	N6-acetyllysine	-	No	None detected
P02545	171	K	N6-succinyllysine	-	No	None detected
P02545	201	K	N6-acetyllysine	-	No	None detected
P02545	212	S	Phosphoserine	-	No	None detected
P02545	260	K	N6-acetyllysine	-	No	None detected
P02545	270	K	N6-acetyllysine	-	No	None detected
P02545	277	S	Phosphoserine	-	No	None detected
P02545	301	S	Phosphoserine	-	No	None detected
P02545	307	S	Phosphoserine	-	No	None detected
P02545	311	K	N6-acetyllysine	-	No	None detected
P02545	390	S	Phosphoserine	-	Yes	p.S390fs (cancer: STAD)
P02545	392	S	Phosphoserine	-	No	None detected
P02545	395	S	Phosphoserine	-	Yes	p.S395L (cancer: UCEC)
P02545	398	S	Phosphoserine	-	No	None detected
P02545	403	S	Phosphoserine	-	No	None detected
P02545	404	S	Phosphoserine	-	No	None detected
P02545	407	S	Phosphoserine	-	No	None detected
P02545	414	S	Phosphoserine	-	No	None detected
P02545	429	S	Phosphoserine	-	No	None detected
P02545	431	S	Phosphoserine	-	No	None detected
P02545	450	K	N6-acetyllysine	-	No	None detected
P02545	457	K	N6-acetyllysine	-	No	None detected
P02545	458	S	Phosphoserine	-	No	None detected
P02545	463	S	Phosphoserine	-	No	None detected
P02545	496	T	Phosphothreonine	-	Yes	p.T496M (cancer: READ)
P02545	505	T	Phosphothreonine	-	No	None detected
P02545	510	T	Phosphothreonine	-	No	None detected
P02545	533	S	Phosphoserine	-	No	None detected
P02545	546	S	Phosphoserine	-	No	None detected
P02545	548	T	Phosphothreonine	-	No	None detected
P02545	568	S	Phosphoserine	-	No	None detected
P02545	571	S	Phosphoserine	-	No	None detected
P02545	612	S	Phosphoserine	-	No	None detected
P02545	613	S	Phosphoserine	-	No	None detected
P02545	616	S	Phosphoserine	-	No	None detected
P02545	619	S	Phosphoserine	-	No	None detected
P02545	628	S	Phosphoserine	-	No	None detected
P02545	632	S	Phosphoserine	-	No	None detected
P02545	636	S	Phosphoserine	-	No	None detected
P02545	652	S	Phosphoserine	-	No	None detected
P02545	661	C	Cysteine methyl ester	-	No	None detected

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

[ TOP ]

Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	9.856	9.273	-0.788	5.51e-05	Under
BRCA	Breast invasive carcinoma	112	1100	8.77	8.691	-0.093	0.262	NS
CESC	Cervical and endocervical cancers	3	306	9.674	9.481	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	8.782	8.705	-0.151	0.146	NS
ESCA	Esophageal carcinoma	11	185	9.302	9.166	0.015	0.963	NS
GBM	Glioblastoma multiforme	5	166	6.429	7.315	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	9.511	9.62	0.077	0.496	NS
KIRC	Kidney renal clear cell carcinoma	72	534	7.628	8.245	0.561	2.96e-10	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	8.035	8.482	0.362	0.000351	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.015	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	6.409	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	7.43	8.438	0.867	1.46e-15	Over
LUAD	Lung adenocarcinoma	59	517	8.964	8.831	-0.349	0.000776	NS
LUSC	Lung squamous cell carcinoma	51	501	9.112	8.803	-0.481	5.99e-06	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	8.32	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	8.537	9.316	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	8.946	8.535	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.908	7.732	-0.331	0.00153	NS
READ	Rectum adenocarcinoma	10	167	8.897	8.629	-0.184	0.395	NS
SARC	Sarcoma	2	263	8.807	9.475	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	10.741	9.889	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	8.968	8.809	-0.215	0.0825	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.269	NA	NA	NA
THCA	Thyroid carcinoma	59	509	8.416	9.161	0.58	2.4e-10	NS
THYM	Thymoma	2	120	7.979	8.146	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	8.957	8.238	-0.634	3.3e-06	Under

> Cancer Cell Line Encyclopedia (CCLE)

[ TOP ]

Tissue	Cell Line	Expression Level (Microarray)
Autonomic ganglia	CHP126	7.1
Autonomic ganglia	CHP212	10.7
Autonomic ganglia	IMR32	5.2
Autonomic ganglia	KELLY	6.8
Autonomic ganglia	KPNRTBM1	6.4
Autonomic ganglia	KPNSI9S	9.2
Autonomic ganglia	KPNYN	6.2
Autonomic ganglia	MHHNB11	8.8
Autonomic ganglia	NB1	9.9
Autonomic ganglia	NH6	7.3
Autonomic ganglia	SHSY5Y	7
Autonomic ganglia	SIMA	5.9
Autonomic ganglia	SKNAS	10.1
Autonomic ganglia	SKNBE2	7.4
Autonomic ganglia	SKNDZ	5.6
Autonomic ganglia	SKNFI	8.8
Autonomic ganglia	SKNSH	9.6
Biliary tract	HUCCT1	9.8
Biliary tract	HUH28	9.8
Biliary tract	SNU1079	9.6
Biliary tract	SNU1196	10.4
Biliary tract	SNU245	10.7
Biliary tract	SNU308	10.1
Biliary tract	SNU478	9.8
Bone	143B	7.5
Bone	A673	9
Bone	CADOES1	7.4
Bone	CAL78	10.1
Bone	G292CLONEA141B1	10.3
Bone	HOS	7.8
Bone	HS706T	10.2
Bone	HS737T	10.4
Bone	HS819T	10.8
Bone	HS821T	10.5
Bone	HS822T	10.6
Bone	HS863T	10.8
Bone	HS870T	10.2
Bone	HS888T	11.4
Bone	MG63	10.6
Bone	MHHES1	9.1
Bone	OUMS27	10.1
Bone	RDES	7.2
Bone	SJSA1	10.2
Bone	SKES1	7.9
Bone	SKNMC	8.5
Bone	SW1353	10
Bone	T173	10.4
Bone	TC71	8.5
Bone	U2OS	9.6
Breast	AU565	10.1
Breast	BT20	9.9
Breast	BT474	9.5
Breast	BT483	9.6
Breast	BT549	10.4
Breast	CAL120	9.4
Breast	CAL148	8.3
Breast	CAL51	8.8
Breast	CAL851	10.4
Breast	CAMA1	9.2
Breast	DU4475	8.6
Breast	EFM192A	9.1
Breast	EFM19	8.7
Breast	EVSAT	9.2
Breast	HCC1143	9.6
Breast	HCC1187	10.1
Breast	HCC1395	10.7
Breast	HCC1419	9.4
Breast	HCC1428	9.8
Breast	HCC1500	8.1
Breast	HCC1569	10.4
Breast	HCC1599	9.9
Breast	HCC1806	9.5
Breast	HCC1937	10.4
Breast	HCC1954	9.9
Breast	HCC202	9.6
Breast	HCC2157	9.6
Breast	HCC2218	9
Breast	HCC38	9.2
Breast	HCC70	10
Breast	HDQP1	9.1
Breast	HMC18	10.1
Breast	HS274T	10.6
Breast	HS281T	10.9
Breast	HS343T	10.9
Breast	HS578T	9.7
Breast	HS606T	10.4
Breast	HS739T	10.1
Breast	HS742T	9.1
Breast	JIMT1	10.2
Breast	KPL1	9.1
Breast	MCF7	8.3
Breast	MDAMB134VI	7.9
Breast	MDAMB157	9.1
Breast	MDAMB175VII	9.4
Breast	MDAMB231	10.9
Breast	MDAMB361	9.2
Breast	MDAMB415	9
Breast	MDAMB436	10.1
Breast	MDAMB453	9.3
Breast	MDAMB468	10.6
Breast	SKBR3	9.8
Breast	T47D	9.4
Breast	UACC812	10.6
Breast	UACC893	9.7
Breast	YMB1	9.3
Breast	ZR751	8.7
Breast	ZR7530	9.8
Central nervous system	1321N1	10.5
Central nervous system	42MGBA	10.3
Central nervous system	8MGBA	8.5
Central nervous system	A172	11.3
Central nervous system	AM38	9.5
Central nervous system	BECKER	10.2
Central nervous system	CAS1	9.1
Central nervous system	CCFSTTG1	9.8
Central nervous system	D283MED	8.2
Central nervous system	D341MED	7
Central nervous system	DAOY	9.7
Central nervous system	DBTRG05MG	9.4
Central nervous system	DKMG	10
Central nervous system	GAMG	9.4
Central nervous system	GB1	10.2
Central nervous system	GI1	9.6
Central nervous system	GMS10	9.5
Central nervous system	GOS3	10.3
Central nervous system	H4	9.7
Central nervous system	HS683	9.7
Central nervous system	KALS1	9.6
Central nervous system	KG1C	9.7
Central nervous system	KNS42	9.5
Central nervous system	KNS60	9
Central nervous system	KNS81	9.6
Central nervous system	KS1	10.5
Central nervous system	LN18	9.5
Central nervous system	LN229	10.6
Central nervous system	M059K	9.9
Central nervous system	MOGGCCM	9.8
Central nervous system	MOGGUVW	10.1
Central nervous system	NMCG1	10.7
Central nervous system	ONS76	9.7
Central nervous system	SF126	9.5
Central nervous system	SF295	10.1
Central nervous system	SNB19	9.7
Central nervous system	SNU1105	10.4
Central nervous system	SNU201	10
Central nervous system	SNU466	10.8
Central nervous system	SNU489	10.7
Central nervous system	SNU626	9.1
Central nervous system	SNU738	10
Central nervous system	SW1088	10.3
Central nervous system	SW1783	9.7
Central nervous system	T98G	10.2
Central nervous system	TM31	9.8
Central nervous system	U118MG	10.9
Central nervous system	U138MG	11.3
Central nervous system	U251MG	8.9
Central nervous system	U87MG	11
Central nervous system	YH13	10.8
Central nervous system	YKG1	9.2
Endometrium	AN3CA	8.7
Endometrium	COLO684	7.2
Endometrium	EFE184	9.3
Endometrium	EN	8.3
Endometrium	ESS1	8.9
Endometrium	HEC108	7.8
Endometrium	HEC151	8.4
Endometrium	HEC1A	9
Endometrium	HEC1B	8.7
Endometrium	HEC251	9.2
Endometrium	HEC265	8.7
Endometrium	HEC50B	9.1
Endometrium	HEC59	8.2
Endometrium	HEC6	8.2
Endometrium	ISHIKAWAHERAKLIO02ER	7.6
Endometrium	JHUEM1	10.3
Endometrium	JHUEM2	9.1
Endometrium	JHUEM3	9
Endometrium	KLE	9.6
Endometrium	MFE280	9.6
Endometrium	MFE296	9
Endometrium	MFE319	9.3
Endometrium	RL952	9.1
Endometrium	SNGM	8.7
Endometrium	SNU1077	9
Endometrium	SNU685	9.4
Endometrium	TEN	8.3
Haematopoietic and lymphoid	697	4.6
Haematopoietic and lymphoid	A3KAW	7.4
Haematopoietic and lymphoid	A4FUK	8.1
Haematopoietic and lymphoid	ALLSIL	5
Haematopoietic and lymphoid	AML193	5.2
Haematopoietic and lymphoid	AMO1	8.9
Haematopoietic and lymphoid	BCP1	4.9
Haematopoietic and lymphoid	BDCM	8.5
Haematopoietic and lymphoid	BL41	4.6
Haematopoietic and lymphoid	BL70	4.3
Haematopoietic and lymphoid	BV173	4.9
Haematopoietic and lymphoid	CA46	6
Haematopoietic and lymphoid	CI1	5.8
Haematopoietic and lymphoid	CMK115	5.3
Haematopoietic and lymphoid	CMK86	6.9
Haematopoietic and lymphoid	CMK	6.8
Haematopoietic and lymphoid	CMLT1	6.4
Haematopoietic and lymphoid	COLO775	8.6
Haematopoietic and lymphoid	DAUDI	5.3
Haematopoietic and lymphoid	DB	5
Haematopoietic and lymphoid	DEL	9.2
Haematopoietic and lymphoid	DND41	4.7
Haematopoietic and lymphoid	DOHH2	5.4
Haematopoietic and lymphoid	EB1	5.8
Haematopoietic and lymphoid	EB2	5.4
Haematopoietic and lymphoid	EHEB	9.6
Haematopoietic and lymphoid	EJM	5.8
Haematopoietic and lymphoid	EM2	5.5
Haematopoietic and lymphoid	EOL1	6.1
Haematopoietic and lymphoid	F36P	8.1
Haematopoietic and lymphoid	GA10	5.5
Haematopoietic and lymphoid	GDM1	5.2
Haematopoietic and lymphoid	GRANTA519	6.6
Haematopoietic and lymphoid	HDLM2	8.5
Haematopoietic and lymphoid	HDMYZ	10
Haematopoietic and lymphoid	HEL9217	7.8
Haematopoietic and lymphoid	HEL	7.7
Haematopoietic and lymphoid	HH	9.3
Haematopoietic and lymphoid	HL60	7.3
Haematopoietic and lymphoid	HPBALL	4.6
Haematopoietic and lymphoid	HS604T	10.3
Haematopoietic and lymphoid	HS611T	7.7
Haematopoietic and lymphoid	HS616T	10.5
Haematopoietic and lymphoid	HS751T	9.9
Haematopoietic and lymphoid	HT	4.9
Haematopoietic and lymphoid	HTK	8.3
Haematopoietic and lymphoid	HUNS1	7.8
Haematopoietic and lymphoid	HUT102	9.6
Haematopoietic and lymphoid	HUT78	5.9
Haematopoietic and lymphoid	JEKO1	7.3
Haematopoietic and lymphoid	JK1	8.5
Haematopoietic and lymphoid	JM1	5.2
Haematopoietic and lymphoid	JURKAT	4.5
Haematopoietic and lymphoid	JURLMK1	7.8
Haematopoietic and lymphoid	JVM2	9.2
Haematopoietic and lymphoid	JVM3	8.4
Haematopoietic and lymphoid	K562	8.9
Haematopoietic and lymphoid	KARPAS299	7.8
Haematopoietic and lymphoid	KARPAS422	5.6
Haematopoietic and lymphoid	KARPAS620	7.3
Haematopoietic and lymphoid	KASUMI1	5.1
Haematopoietic and lymphoid	KASUMI2	4.6
Haematopoietic and lymphoid	KASUMI6	5
Haematopoietic and lymphoid	KCL22	6.3
Haematopoietic and lymphoid	KE37	4.7
Haematopoietic and lymphoid	KE97	8.1
Haematopoietic and lymphoid	KG1	4.8
Haematopoietic and lymphoid	KHM1B	9.3
Haematopoietic and lymphoid	KIJK	7.9
Haematopoietic and lymphoid	KMH2	9.2
Haematopoietic and lymphoid	KMM1	6.7
Haematopoietic and lymphoid	KMS11	8.2
Haematopoietic and lymphoid	KMS12BM	5.5
Haematopoietic and lymphoid	KMS18	7.7
Haematopoietic and lymphoid	KMS20	7.4
Haematopoietic and lymphoid	KMS21BM	9.9
Haematopoietic and lymphoid	KMS26	8.2
Haematopoietic and lymphoid	KMS27	7
Haematopoietic and lymphoid	KMS28BM	6.9
Haematopoietic and lymphoid	KMS34	6.2
Haematopoietic and lymphoid	KO52	5
Haematopoietic and lymphoid	KOPN8	5
Haematopoietic and lymphoid	KU812	9.2
Haematopoietic and lymphoid	KYO1	9.7
Haematopoietic and lymphoid	L1236	9.2
Haematopoietic and lymphoid	L363	6.1
Haematopoietic and lymphoid	L428	7.4
Haematopoietic and lymphoid	L540	8.8
Haematopoietic and lymphoid	LAMA84	8.5
Haematopoietic and lymphoid	LOUCY	4.7
Haematopoietic and lymphoid	LP1	8.4
Haematopoietic and lymphoid	M07E	8.2
Haematopoietic and lymphoid	MC116	5.9
Haematopoietic and lymphoid	ME1	5.2
Haematopoietic and lymphoid	MEC1	5.6
Haematopoietic and lymphoid	MEC2	5.5
Haematopoietic and lymphoid	MEG01	8.3
Haematopoietic and lymphoid	MHHCALL2	4.7
Haematopoietic and lymphoid	MHHCALL3	4.8
Haematopoietic and lymphoid	MHHCALL4	4.5
Haematopoietic and lymphoid	MINO	5.1
Haematopoietic and lymphoid	MJ	9.5
Haematopoietic and lymphoid	MM1S	6.3
Haematopoietic and lymphoid	MOLM13	8.4
Haematopoietic and lymphoid	MOLM16	7.7
Haematopoietic and lymphoid	MOLM6	6
Haematopoietic and lymphoid	MOLP2	6.7
Haematopoietic and lymphoid	MOLP8	6.9
Haematopoietic and lymphoid	MOLT13	4.9
Haematopoietic and lymphoid	MOLT16	4.6
Haematopoietic and lymphoid	MOLT4	4.6
Haematopoietic and lymphoid	MONOMAC1	8.1
Haematopoietic and lymphoid	MONOMAC6	7.7
Haematopoietic and lymphoid	MOTN1	8.6
Haematopoietic and lymphoid	MUTZ5	4.6
Haematopoietic and lymphoid	MV411	8.5
Haematopoietic and lymphoid	NALM19	4.8
Haematopoietic and lymphoid	NALM1	5
Haematopoietic and lymphoid	NALM6	5
Haematopoietic and lymphoid	NAMALWA	5.2
Haematopoietic and lymphoid	NB4	7.6
Haematopoietic and lymphoid	NCIH929	9.1
Haematopoietic and lymphoid	NCO2	8.1
Haematopoietic and lymphoid	NOMO1	8
Haematopoietic and lymphoid	NUDHL1	8.7
Haematopoietic and lymphoid	NUDUL1	5.4
Haematopoietic and lymphoid	OCIAML2	7.5
Haematopoietic and lymphoid	OCIAML3	9
Haematopoietic and lymphoid	OCIAML5	5.9
Haematopoietic and lymphoid	OCILY10	6
Haematopoietic and lymphoid	OCILY19	5
Haematopoietic and lymphoid	OCILY3	5.1
Haematopoietic and lymphoid	OCIM1	9
Haematopoietic and lymphoid	OPM2	8.7
Haematopoietic and lymphoid	P12ICHIKAWA	4.8
Haematopoietic and lymphoid	P31FUJ	5
Haematopoietic and lymphoid	P3HR1	5.4
Haematopoietic and lymphoid	PCM6	6.3
Haematopoietic and lymphoid	PEER	4.8
Haematopoietic and lymphoid	PF382	4.9
Haematopoietic and lymphoid	PFEIFFER	5
Haematopoietic and lymphoid	PL21	6.5
Haematopoietic and lymphoid	RAJI	5.1
Haematopoietic and lymphoid	RCHACV	4.5
Haematopoietic and lymphoid	REC1	4.6
Haematopoietic and lymphoid	REH	4.9
Haematopoietic and lymphoid	RI1	5.7
Haematopoietic and lymphoid	RL	5.6
Haematopoietic and lymphoid	RPMI8226	8.6
Haematopoietic and lymphoid	RPMI8402	5.1
Haematopoietic and lymphoid	RS411	4.8
Haematopoietic and lymphoid	SEM	4.8
Haematopoietic and lymphoid	SET2	8.9
Haematopoietic and lymphoid	SIGM5	8.4
Haematopoietic and lymphoid	SKM1	6.8
Haematopoietic and lymphoid	SKMM2	7.8
Haematopoietic and lymphoid	SR786	9
Haematopoietic and lymphoid	ST486	5
Haematopoietic and lymphoid	SUDHL10	5.4
Haematopoietic and lymphoid	SUDHL1	5.8
Haematopoietic and lymphoid	SUDHL4	5.5
Haematopoietic and lymphoid	SUDHL5	5.2
Haematopoietic and lymphoid	SUDHL6	4.9
Haematopoietic and lymphoid	SUDHL8	5.5
Haematopoietic and lymphoid	SUPB15	4.9
Haematopoietic and lymphoid	SUPHD1	8.6
Haematopoietic and lymphoid	SUPM2	7.4
Haematopoietic and lymphoid	SUPT11	5.2
Haematopoietic and lymphoid	SUPT1	4.8
Haematopoietic and lymphoid	TALL1	5.1
Haematopoietic and lymphoid	TF1	8
Haematopoietic and lymphoid	THP1	8.5
Haematopoietic and lymphoid	TO175T	10.9
Haematopoietic and lymphoid	TOLEDO	5.2
Haematopoietic and lymphoid	U266B1	5.2
Haematopoietic and lymphoid	U937	8
Haematopoietic and lymphoid	UT7	9
Haematopoietic and lymphoid	WSUDLCL2	5.2
Kidney	769P	10.1
Kidney	786O	10
Kidney	A498	10.2
Kidney	A704	7.2
Kidney	ACHN	9.8
Kidney	BFTC909	9.2
Kidney	CAKI1	9.4
Kidney	CAKI2	10.1
Kidney	CAL54	9.2
Kidney	KMRC1	10
Kidney	KMRC20	9.4
Kidney	KMRC2	9.4
Kidney	KMRC3	9.1
Kidney	OSRC2	9.8
Kidney	RCC10RGB	8.9
Kidney	SNU1272	9.8
Kidney	SNU349	10
Kidney	TUHR10TKB	10
Kidney	TUHR14TKB	9.7
Kidney	TUHR4TKB	9.5
Kidney	VMRCRCW	8.9
Kidney	VMRCRCZ	9
Large intestine	C2BBE1	8.5
Large intestine	CCK81	8.7
Large intestine	CL11	10.7
Large intestine	CL14	9.2
Large intestine	CL34	9.4
Large intestine	CL40	10.5
Large intestine	COLO205	10.1
Large intestine	COLO320	4.9
Large intestine	COLO678	10.5
Large intestine	CW2	9.2
Large intestine	DLD1	9.9
Large intestine	GP2D	8.4
Large intestine	HCC56	9.5
Large intestine	HCT116	9.9
Large intestine	HCT15	9.3
Large intestine	HS675T	10.4
Large intestine	HS698T	10.6
Large intestine	HT115	9.6
Large intestine	HT29	10.5
Large intestine	HT55	8.8
Large intestine	KM12	8.8
Large intestine	LOVO	9.4
Large intestine	LS1034	8.9
Large intestine	LS123	10.3
Large intestine	LS180	9.6
Large intestine	LS411N	7.9
Large intestine	LS513	10.1
Large intestine	MDST8	10.2
Large intestine	NCIH508	9.4
Large intestine	NCIH716	9.1
Large intestine	NCIH747	10.6
Large intestine	OUMS23	9.1
Large intestine	RCM1	9.6
Large intestine	RKO	6.5
Large intestine	SKCO1	9.9
Large intestine	SNU1040	8.9
Large intestine	SNU1197	10.8
Large intestine	SNU175	9.2
Large intestine	SNU283	9.6
Large intestine	SNU407	9.9
Large intestine	SNU503	9.7
Large intestine	SNU61	10.3
Large intestine	SNU81	9.9
Large intestine	SNUC1	10.1
Large intestine	SNUC2A	9.4
Large intestine	SNUC4	9.1
Large intestine	SNUC5	9.5
Large intestine	SW1116	9.5
Large intestine	SW1417	9.9
Large intestine	SW1463	9.3
Large intestine	SW403	9.6
Large intestine	SW480	9.7
Large intestine	SW48	9.6
Large intestine	SW620	9.2
Large intestine	SW837	9.2
Large intestine	SW948	9.1
Large intestine	T84	10.3
Liver	ALEXANDERCELLS	8.5
Liver	C3A	9
Liver	HEP3B217	8.4
Liver	HEPG2	9.3
Liver	HLE	9.4
Liver	HLF	10.2
Liver	HUH1	9.6
Liver	HUH6	8.2
Liver	HUH7	8.1
Liver	JHH1	9.3
Liver	JHH2	10.9
Liver	JHH4	9.9
Liver	JHH5	9.2
Liver	JHH6	9.3
Liver	JHH7	7.4
Liver	LI7	9.1
Liver	PLCPRF5	8.8
Liver	SKHEP1	10.2
Liver	SNU182	8.2
Liver	SNU387	11
Liver	SNU398	6.8
Liver	SNU423	9.9
Liver	SNU449	9.7
Liver	SNU475	10.3
Liver	SNU761	10.2
Liver	SNU878	9.6
Liver	SNU886	10.8
Lung	A549	9.7
Lung	ABC1	9.6
Lung	BEN	9.6
Lung	CAL12T	9.4
Lung	CALU1	11.2
Lung	CALU3	9.4
Lung	CALU6	9.6
Lung	CHAGOK1	9
Lung	COLO668	7.9
Lung	COLO699	10.3
Lung	CORL105	10.2
Lung	CORL23	9.2
Lung	CORL24	8.3
Lung	CORL279	6.7
Lung	CORL311	5.8
Lung	CORL47	6.1
Lung	CORL51	7.3
Lung	CORL88	6.6
Lung	CORL95	7.7
Lung	CPCN	8.3
Lung	DMS114	7.9
Lung	DMS153	8.5
Lung	DMS273	7.1
Lung	DMS454	7.9
Lung	DMS53	6.2
Lung	DMS79	7.3
Lung	DV90	8.3
Lung	EBC1	9.9
Lung	EPLC272H	9.5
Lung	HARA	9.8
Lung	HCC1171	10.8
Lung	HCC1195	10
Lung	HCC15	10.2
Lung	HCC2279	9.1
Lung	HCC2935	10.5
Lung	HCC33	6.5
Lung	HCC366	9.2
Lung	HCC4006	9.6
Lung	HCC44	8.9
Lung	HCC78	10.3
Lung	HCC827	9
Lung	HCC95	8.3
Lung	HLC1	9.1
Lung	HLFA	10.2
Lung	HS229T	10.3
Lung	HS618T	10.5
Lung	IALM	10.2
Lung	KNS62	10.2
Lung	LC1F	9.2
Lung	LC1SQSF	9.5
Lung	LCLC103H	9.7
Lung	LCLC97TM1	9.5
Lung	LK2	7.7
Lung	LOUNH91	10.4
Lung	LU65	9.5
Lung	LU99	8.7
Lung	LUDLU1	9.7
Lung	LXF289	9.4
Lung	MORCPR	9.8
Lung	NCIH1048	7.6
Lung	NCIH1092	5.4
Lung	NCIH1105	5.4
Lung	NCIH1155	7.5
Lung	NCIH1184	6.4
Lung	NCIH1299	10.3
Lung	NCIH1339	8.5
Lung	NCIH1341	9.7
Lung	NCIH1355	9.2
Lung	NCIH1373	10.4
Lung	NCIH1385	9
Lung	NCIH1395	8.5
Lung	NCIH1435	9.8
Lung	NCIH1436	6.1
Lung	NCIH1437	8.9
Lung	NCIH146	5.6
Lung	NCIH1563	9.4
Lung	NCIH1568	8.9
Lung	NCIH1573	9.4
Lung	NCIH1581	7.5
Lung	NCIH1618	7.7
Lung	NCIH1623	9.5
Lung	NCIH1648	9.1
Lung	NCIH1650	10
Lung	NCIH1651	9
Lung	NCIH1666	9.8
Lung	NCIH1693	8.6
Lung	NCIH1694	7.3
Lung	NCIH1703	9.2
Lung	NCIH1734	9.8
Lung	NCIH1755	9.7
Lung	NCIH1781	9.8
Lung	NCIH1792	9.6
Lung	NCIH1793	10.1
Lung	NCIH1836	5.7
Lung	NCIH1838	10
Lung	NCIH1869	10.5
Lung	NCIH1876	7
Lung	NCIH1915	9
Lung	NCIH1930	6.1
Lung	NCIH1944	9.1
Lung	NCIH1963	6.5
Lung	NCIH196	10.7
Lung	NCIH1975	10.6
Lung	NCIH2009	10.5
Lung	NCIH2023	9.2
Lung	NCIH2029	6.5
Lung	NCIH2030	10.1
Lung	NCIH2066	6.3
Lung	NCIH2081	5.9
Lung	NCIH2085	9.6
Lung	NCIH2087	10
Lung	NCIH209	6.9
Lung	NCIH2106	8.4
Lung	NCIH2110	9.9
Lung	NCIH211	5.8
Lung	NCIH2122	9.7
Lung	NCIH2126	8.8
Lung	NCIH2141	7.4
Lung	NCIH2170	10.1
Lung	NCIH2171	6.6
Lung	NCIH2172	8.7
Lung	NCIH2196	8.4
Lung	NCIH2227	7
Lung	NCIH2228	10.8
Lung	NCIH226	10.2
Lung	NCIH2286	9.1
Lung	NCIH2291	9.9
Lung	NCIH2342	10.1
Lung	NCIH2347	10.3
Lung	NCIH23	9.3
Lung	NCIH2405	9.8
Lung	NCIH2444	10.3
Lung	NCIH292	9.5
Lung	NCIH322	10.6
Lung	NCIH3255	10.5
Lung	NCIH358	10.6
Lung	NCIH441	10.5
Lung	NCIH446	8.8
Lung	NCIH460	10
Lung	NCIH510	6.9
Lung	NCIH520	8.1
Lung	NCIH522	7.6
Lung	NCIH524	4.6
Lung	NCIH526	6.9
Lung	NCIH596	9.8
Lung	NCIH647	9.7
Lung	NCIH650	8.3
Lung	NCIH661	8.8
Lung	NCIH69	6.6
Lung	NCIH727	8.6
Lung	NCIH810	9.2
Lung	NCIH82	6.5
Lung	NCIH838	9
Lung	NCIH841	8.6
Lung	NCIH854	9.1
Lung	NCIH889	5.2
Lung	PC14	9.8
Lung	RERFLCAD1	10
Lung	RERFLCAD2	9.3
Lung	RERFLCAI	10.2
Lung	RERFLCKJ	10.2
Lung	RERFLCMS	10
Lung	RERFLCSQ1	9.7
Lung	SBC5	8.6
Lung	SCLC21H	7.3
Lung	SHP77	8.5
Lung	SKLU1	10.4
Lung	SKMES1	10.4
Lung	SQ1	10.8
Lung	SW1271	10.1
Lung	SW1573	9.2
Lung	SW900	10.9
Lung	VMRCLCD	8.4
Lung	VMRCLCP	8.3
Oesophagus	COLO680N	9.4
Oesophagus	ECGI10	8.6
Oesophagus	KYSE140	9.7
Oesophagus	KYSE150	9.3
Oesophagus	KYSE180	9.4
Oesophagus	KYSE270	9.4
Oesophagus	KYSE30	10.7
Oesophagus	KYSE410	9.7
Oesophagus	KYSE450	8.7
Oesophagus	KYSE510	10.2
Oesophagus	KYSE520	9.6
Oesophagus	KYSE70	9.6
Oesophagus	OE19	10.8
Oesophagus	OE33	8.8
Oesophagus	TE10	10.1
Oesophagus	TE11	10.2
Oesophagus	TE14	9.6
Oesophagus	TE15	10.3
Oesophagus	TE1	9.9
Oesophagus	TE4	9.4
Oesophagus	TE5	9.3
Oesophagus	TE6	8.3
Oesophagus	TE8	8.9
Oesophagus	TE9	9.7
Oesophagus	TT	8.9
Ovary	59M	10.5
Ovary	A2780	7.2
Ovary	CAOV3	8.5
Ovary	CAOV4	9.2
Ovary	COLO704	6.4
Ovary	COV318	9.1
Ovary	COV362	10.2
Ovary	COV434	7.3
Ovary	COV504	10.5
Ovary	COV644	9.4
Ovary	EFO21	9.5
Ovary	EFO27	9.8
Ovary	ES2	8.8
Ovary	FUOV1	9.4
Ovary	HEYA8	9.6
Ovary	HS571T	10.7
Ovary	IGROV1	10.2
Ovary	JHOC5	9.3
Ovary	JHOM1	9.2
Ovary	JHOM2B	9.5
Ovary	JHOS2	9.3
Ovary	JHOS4	8.8
Ovary	KURAMOCHI	10.6
Ovary	MCAS	10.2
Ovary	NIHOVCAR3	10.2
Ovary	OAW28	8.6
Ovary	OAW42	9.7
Ovary	OC314	9
Ovary	OC316	8.8
Ovary	ONCODG1	9.9
Ovary	OV56	8.5
Ovary	OV7	10.7
Ovary	OV90	8.9
Ovary	OVCAR4	9.4
Ovary	OVCAR8	9.1
Ovary	OVISE	9.3
Ovary	OVK18	8.4
Ovary	OVKATE	9.4
Ovary	OVMANA	8.7
Ovary	OVSAHO	9.2
Ovary	OVTOKO	9.7
Ovary	RMGI	9.1
Ovary	RMUGS	10.6
Ovary	SKOV3	9.8
Ovary	SNU119	9.3
Ovary	SNU840	10.2
Ovary	SNU8	9.4
Ovary	TOV112D	6.5
Ovary	TOV21G	9
Ovary	TYKNU	9.8
Pancreas	ASPC1	10.1
Pancreas	BXPC3	10.2
Pancreas	CAPAN1	9.5
Pancreas	CAPAN2	9.9
Pancreas	CFPAC1	10.1
Pancreas	DANG	9.7
Pancreas	HPAC	9.2
Pancreas	HPAFII	9.8
Pancreas	HS766T	10.7
Pancreas	HUPT3	9.5
Pancreas	HUPT4	9.7
Pancreas	KCIMOH1	9.7
Pancreas	KLM1	11
Pancreas	KP2	10.9
Pancreas	KP3	9.2
Pancreas	KP4	8.6
Pancreas	L33	9.1
Pancreas	MIAPACA2	10.3
Pancreas	PANC0203	9.6
Pancreas	PANC0213	9.6
Pancreas	PANC0327	9.5
Pancreas	PANC0403	10.7
Pancreas	PANC0504	10.1
Pancreas	PANC0813	9.7
Pancreas	PANC1005	10.4
Pancreas	PANC1	10
Pancreas	PATU8902	10.3
Pancreas	PATU8988S	8.9
Pancreas	PATU8988T	8.9
Pancreas	PK1	10.1
Pancreas	PK45H	10.6
Pancreas	PK59	9.4
Pancreas	PL45	10.2
Pancreas	PSN1	10.2
Pancreas	QGP1	8.1
Pancreas	SNU213	9.7
Pancreas	SNU324	10.3
Pancreas	SNU410	10.7
Pancreas	SU8686	9.2
Pancreas	SUIT2	9.3
Pancreas	SW1990	9.9
Pancreas	T3M4	9.7
Pancreas	TCCPAN2	10.8
Pancreas	YAPC	9.8
Pleura	ACCMESO1	9.8
Pleura	DM3	11
Pleura	ISTMES1	10.8
Pleura	ISTMES2	9.9
Pleura	JL1	10.6
Pleura	MPP89	9.8
Pleura	MSTO211H	8.4
Pleura	NCIH2052	10.1
Pleura	NCIH2452	10.2
Pleura	NCIH28	9.8
Prostate	22RV1	8.6
Prostate	DU145	10.1
Prostate	LNCAPCLONEFGC	6.8
Prostate	MDAPCA2B	7.7
Prostate	NCIH660	7.6
Prostate	PC3	9.8
Prostate	VCAP	5.9
Salivary gland	A253	9.9
Salivary gland	YD15	9.4
Skin	A101D	10
Skin	A2058	10.1
Skin	A375	11.3
Skin	C32	11.2
Skin	CHL1	10
Skin	CJM	9
Skin	COLO679	9.6
Skin	COLO741	9.7
Skin	COLO783	10.4
Skin	COLO792	9.5
Skin	COLO800	11
Skin	COLO818	10.4
Skin	COLO829	11.2
Skin	COLO849	11.1
Skin	G361	10.2
Skin	GRM	10.8
Skin	HMCB	10
Skin	HS294T	10.8
Skin	HS600T	10.5
Skin	HS688AT	11.2
Skin	HS695T	11.4
Skin	HS839T	11.3
Skin	HS852T	10.9
Skin	HS895T	10.1
Skin	HS934T	11.3
Skin	HS936T	10.1
Skin	HS939T	11.2
Skin	HS940T	10.6
Skin	HS944T	10.4
Skin	HT144	10.8
Skin	IGR1	8.9
Skin	IGR37	10.4
Skin	IGR39	10.6
Skin	IPC298	10.5
Skin	K029AX	10.8
Skin	LOXIMVI	9.8
Skin	MALME3M	10.4
Skin	MDAMB435S	9.7
Skin	MELHO	9.8
Skin	MELJUSO	10.8
Skin	MEWO	9.3
Skin	RPMI7951	10.4
Skin	RVH421	10.1
Skin	SH4	9.9
Skin	SKMEL1	8.8
Skin	SKMEL24	10.5
Skin	SKMEL28	10.1
Skin	SKMEL2	10
Skin	SKMEL30	10.5
Skin	SKMEL31	10
Skin	SKMEL3	10.4
Skin	SKMEL5	10.4
Skin	UACC257	9.7
Skin	UACC62	10.1
Skin	WM115	11.4
Skin	WM1799	10.6
Skin	WM2664	10.5
Skin	WM793	11
Skin	WM88	10.3
Skin	WM983B	9.7
Small intestine	HUTU80	7.2
Soft tissue	A204	10.3
Soft tissue	G401	8.6
Soft tissue	G402	9.3
Soft tissue	GCT	9.4
Soft tissue	HS729	10.5
Soft tissue	HT1080	10.1
Soft tissue	KYM1	9.2
Soft tissue	MESSA	8.8
Soft tissue	RD	9.7
Soft tissue	RH30	10
Soft tissue	RH41	9.4
Soft tissue	RKN	9.4
Soft tissue	S117	10.3
Soft tissue	SJRH30	8
Soft tissue	SKLMS1	9.8
Soft tissue	SKUT1	9
Soft tissue	TE125T	10.2
Soft tissue	TE159T	10.9
Soft tissue	TE441T	8.4
Soft tissue	TE617T	8.3
Stomach	2313287	9.6
Stomach	AGS	9.9
Stomach	AZ521	7.6
Stomach	ECC10	6.3
Stomach	ECC12	7.2
Stomach	FU97	8.4
Stomach	GCIY	8.8
Stomach	GSS	7
Stomach	GSU	9.5
Stomach	HGC27	9.7
Stomach	HS746T	9.8
Stomach	HUG1N	9.9
Stomach	IM95	9.7
Stomach	KATOIII	10.2
Stomach	KE39	8.8
Stomach	LMSU	10.1
Stomach	MKN1	9.7
Stomach	MKN45	9.5
Stomach	MKN74	8.5
Stomach	MKN7	10.3
Stomach	NCCSTCK140	9.7
Stomach	NCIN87	9.6
Stomach	NUGC2	10.3
Stomach	NUGC3	10
Stomach	NUGC4	10
Stomach	OCUM1	9.8
Stomach	RERFGC1B	9.4
Stomach	SH10TC	9.8
Stomach	SNU16	8.9
Stomach	SNU1	7.6
Stomach	SNU216	9
Stomach	SNU520	10.1
Stomach	SNU5	10.4
Stomach	SNU601	10.6
Stomach	SNU620	9.1
Stomach	SNU668	9.4
Stomach	SNU719	10.2
Stomach	TGBC11TKB	10
Thyroid	8305C	9.3
Thyroid	8505C	10
Thyroid	BCPAP	8.7
Thyroid	BHT101	9.3
Thyroid	CAL62	8.8
Thyroid	CGTHW1	10.5
Thyroid	FTC133	10.1
Thyroid	FTC238	8.9
Thyroid	ML1	9.6
Thyroid	SW579	11.2
Thyroid	TT2609C02	10.2
Thyroid	TT	7.2
Upper aerodigestive tract	BHY	9.1
Upper aerodigestive tract	BICR16	9.3
Upper aerodigestive tract	BICR18	9.6
Upper aerodigestive tract	BICR22	9.1
Upper aerodigestive tract	BICR31	9
Upper aerodigestive tract	BICR56	8.6
Upper aerodigestive tract	BICR6	9.3
Upper aerodigestive tract	CAL27	9.9
Upper aerodigestive tract	CAL33	9.7
Upper aerodigestive tract	DETROIT562	9.5
Upper aerodigestive tract	FADU	9.4
Upper aerodigestive tract	HS840T	10.7
Upper aerodigestive tract	HSC2	9.2
Upper aerodigestive tract	HSC3	9.3
Upper aerodigestive tract	HSC4	9.5
Upper aerodigestive tract	PECAPJ15	9.5
Upper aerodigestive tract	PECAPJ34CLONEC12	10.2
Upper aerodigestive tract	PECAPJ41CLONED2	9.8
Upper aerodigestive tract	PECAPJ49	8.7
Upper aerodigestive tract	SCC15	9.3
Upper aerodigestive tract	SCC25	10.3
Upper aerodigestive tract	SCC4	9
Upper aerodigestive tract	SCC9	9.6
Upper aerodigestive tract	SNU1076	9.4
Upper aerodigestive tract	SNU1214	9.9
Upper aerodigestive tract	SNU46	10.2
Upper aerodigestive tract	SNU899	9.8
Upper aerodigestive tract	YD10B	10.3
Upper aerodigestive tract	YD38	10.2
Upper aerodigestive tract	YD8	9.4
Urinary tract	5637	9.7
Urinary tract	639V	8.6
Urinary tract	647V	9.8
Urinary tract	BC3C	10.1
Urinary tract	BFTC905	9.6
Urinary tract	CAL29	9.9
Urinary tract	HS172T	9.8
Urinary tract	HT1197	9.7
Urinary tract	HT1376	10.6
Urinary tract	J82	10.2
Urinary tract	JMSU1	11.4
Urinary tract	KMBC2	8.5
Urinary tract	KU1919	9.7
Urinary tract	RT11284	9.6
Urinary tract	RT112	10.4
Urinary tract	RT4	9.2
Urinary tract	SCABER	9.8
Urinary tract	SW1710	9.9
Urinary tract	SW780	9.7
Urinary tract	T24	10
Urinary tract	TCCSUP	9.9
Urinary tract	UMUC1	10.4
Urinary tract	UMUC3	9.1
Urinary tract	VMCUB1	9.5

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Expression Level (TPM)
Adipose tissue	295.5
Adrenal gland	152.9
Appendix	181.7
Bone marrow	69.4
Breast	143.4
Cerebral cortex	53.7
Cervix, uterine	213.3
Colon	137.7
Duodenum	132.5
Endometrium	203.7
Epididymis	30.9
Esophagus	221.5
Fallopian tube	126.5
Gallbladder	344.5
Heart muscle	82.1
Kidney	47.7
Liver	42.3
Lung	225.2
Lymph node	42.2
Ovary	118.9
Pancreas	28.9
Parathyroid gland	102.1
Placenta	142.9
Prostate	110.4
Rectum	74.1
Salivary gland	41.6
Seminal vesicle	116
Skeletal muscle	55.1
Skin	278
Small intestine	127.2
Smooth muscle	230.6
Spleen	85.8
Stomach	158.8
Testis	80.8
Thyroid gland	106.5
Tonsil	44.1
Urinary bladder	163

> Text Mining based Expression

[ TOP ]

PMID	Expression	Cancer	Evidence
26537870	Underexpression; Loss of Expression	Cervical Carcinoma	Normal lamin A/C expression (group A) was observed in 39% of the CUS, weak lamin A/C expression (group B) was observed in 28% of the CUS and no lamin A/C expression (group C) was observed in 33% of the CUS tested.
26469707	Underexpression	Prostate Carcinoma	Reduced amounts of lamin A/C and B2 increase risk for lymph node metastasis and disease specific death possibly through increased nuclear deformability while high expression of lamin B1 predicts disease recurrence.
26439802	Underexpression	human Neuroblastoma	We also demonstrates that the development of TICs is due to an increased expression of MYCN gene and that in neuroblastoma exists an inverse relationship between LMNA and MYCN expression.
26254781	Overexpression	papillary carcinoma; meduallary carcinoma	In papillary carcinomas (PCs), the nuclear proteins most frequently expressed at high levels were emerin (82 % positive), lamin A/C (64 %), and LAP2 (82 %). In all medullary carcinomas (MCs), intermediate to high levels of expression of lamin A/C and LAP2 were found.
26175118	Underexpression	Breast Carcinoma	Using immunohistology, we found that a nuclear lamina component, lamin A/C and all of the investigated LINC complex components, SUN1, SUN2, and nesprin-2, were downregulated in human breast cancer tissues
25770192	altered expression	Pancreatic Carcinoma	In order to investigate known stress-evasion strategies observed in pancreatic cancer, the stress-resistant KLM1-derived cell lines KLM1-R (Gemcitabine (GEM)-induced stress) and KLM1-S (growth factor restriction-induced stress) were employed. Proteomic analysis revealed changes in the expression levels of 6 proteins, namely: transitional endoplasmic reticulum ATPase, lamin A/C, PDZ and LIM protein 1, calmodulin, heat shock protein 60 and alpha enolase.
25192722	Underexpression	Ovarian Carcinoma	This study is to investigate the key proteins which may play an important role in the VEGF-induced progress of ovarian cancer cells. A total of 17 expressed differential proteins were identified, 8 proteins were upregulated (ACTB, TIM, PDIA3, PDIA1, DCTN2, KIC17, SIAS, and KIC10) and 9 downregulated (KIC18, GRP78, CAPG, PPIA, ROA2, LMNA, EZRI, ADRM1, and ENOA).
24608381	Underexpression	Ovarian Carcinoma	The relative expression levels of Ezrin and Lamin A/C mRNA in the epithelial ovarian cancer specimens were (0.026±0.003) and (0.060±0.007), respectively, which were significantly lower than those in the normal ovarian specimens (P<0.05)
24293108	altered expression	Bladder Carcinoma	In this study, we have studied the relationships between the mRNA expressions of A-type lamins, LMNB1 and LBR and the clinicopathological parameters in human breast cancer. Higher lamin A/C expression was associated with the early clinical stage (TNM1 vs. TNM3 - 13 vs. 0.21; p = 0.0515), with better clinical outcomes (disease-free survival vs. mortality - 11 vs. 1; p = 0.0326), and with better overall (p = 0.004) and disease-free survival (p = 0.062).
21627864	Loss of Expression	Breast Carcinoma	We found that nuclear lamina proteins lamin A/C are absent in a significant fraction (38%) of human breast cancer tissues
21621406	Underexpression	Colon Carcinoma	Low levels of LMNA expression were observed in 17.8% of colon tumours, with disease recurrence occurring in 45.5% of stage II and III colon cancer patients with LMNA-low expressing tumours compared to 29.6% of patients with LMNA-high expressing tumours (p=0.01).
21439080	Loss of Expression	Ovarian Carcinoma	We found that nuclear lamina proteins lamin A/C are often absent (47%) in ovarian cancer cells and tissues.
19144202	Underexpression	Primary gastric cancer	Both lamin A/C mRNA and protein expression were downregulated in the majority of tumours compared with corresponding normal gastric tissues (p = 0.011 and p = 0.036, respectively).
19121265	Overexpression	Colorectal Carcinoma	CRC (colorectal cancer) patients expressing lamin A/C in their tumour tissue were found to have a 2-fold greater risk of CRC-related mortality compared with patients with lamin A/C-negative tumours.
18320592	Overexpression	Esophageal Carcinoma	Fifteen proteins were identified with differences of more than five folds, comprising the down-regulation of annexin A2, histone deacetylase 10 isoform beta and protein disulfide-isomerase ER-60 precursor, and the up-regulation of heat shock 70 kDa protein 9B precursor, solute carrier family 44 Member 3, heterogeneous nuclear ribonucleoprotein L (hnRNP L), eukaryotic translation initiation factor 4A isoform 2, triosephosphate isomerase1 (TPI), peroxiredoxin1 (PRX1), forminotransferase cyclodeaminase form (FTCD), fibrinogen gamma-A chain precursor, kinesin-like DNA binding protein, lamin A/C, cyclophilin A (CypA), and transcription factor MTSG1.
17954908	Overexpression	Ovarian Carcinoma	We have used protein microarrays and autoantibodies from cancer patients to identify proteins that are aberrantly expressed in ovarian tissue. Lamin A/C, SSRP1, and RALBP1 were found to exhibit increased expression in the cancer tissue relative to controls.
15867203	loss of expression (hypermethylation)	Leukemia; Lymphoma	Epigenetic silencing of the lamin A/C gene by CpG island promoter hypermethylation is responsible for the Loss of expression of A-type lamins in leukemias and lymphomas.
10517909	Underexpression	Colon Carcinoma; adenoma; Gastric Carcinoma	The expression of lamin A/C was reduced and was frequently undetectable by immunohistochemistry in all primary colon carcinomas and adenomas, and in 7/8 primary gastric cancers

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.134	0.00679	6.4	48.3	45.3	Gain
BRCA	Breast invasive carcinoma	1075	0.344	2.6e-31	1.7	25.5	72.8	Gain
CESC	Cervical and endocervical cancers	292	0.32	2.24e-08	2.4	43.8	53.8	Gain
COAD	Colon adenocarcinoma	449	0.213	5.27e-06	9.1	70.4	20.5	Neutral
ESCA	Esophageal carcinoma	183	0.138	0.0632	4.4	46.4	49.2	Gain
GBM	Glioblastoma multiforme	147	0.28	0.000583	2	78.9	19	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.111	0.0116	7.2	67.7	25.1	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.201	3.4e-06	6.5	81.7	11.8	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	0.13	0.0269	6.6	87.8	5.6	Neutral
LAML	Acute Myeloid Leukemia	166	0.072	0.358	0	98.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.147	0.000866	1.9	90.3	7.8	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.562	9.7e-32	0.3	25	74.7	Gain
LUAD	Lung adenocarcinoma	512	0.259	2.54e-09	2	24.8	73.2	Gain
LUSC	Lung squamous cell carcinoma	498	0.208	2.91e-06	4.6	43.2	52.2	Gain
OV	Ovarian serous cystadenocarcinoma	300	0.243	2.17e-05	2.3	34.7	63	Gain
PAAD	Pancreatic adenocarcinoma	177	0.48	1.44e-11	3.4	63.8	32.8	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.2	0.0106	8.6	74.7	16.7	Neutral
PRAD	Prostate adenocarcinoma	491	0.124	0.00614	3.3	90.2	6.5	Neutral
READ	Rectum adenocarcinoma	164	0.298	0.000107	7.9	63.4	28.7	Neutral
SARC	Sarcoma	255	0.351	8.26e-09	7.5	55.7	36.9	Gain
SKCM	Skin Cutaneous Melanoma	367	0.357	1.69e-12	3.8	41.7	54.5	Gain
STAD	Stomach adenocarcinoma	413	0.162	0.000946	3.4	60.5	36.1	Gain
TGCT	Testicular Germ Cell Tumors	150	0.132	0.108	0.7	54	45.3	Gain
THCA	Thyroid carcinoma	497	0.164	0.000232	0.6	94	5.4	Neutral
THYM	Thymoma	119	0.309	0.000638	0	79.8	20.2	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.196	4.97e-06	0.2	52	47.9	Gain

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

[ TOP ]

Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.195	5.24e-05	17	408	-0.011	0.74	NS/NA
BRCA	Breast invasive carcinoma	-0.239	1.05e-12	83	785	0.036	4.63e-05	NS/NA
CESC	Cervical and endocervical cancers	-0.264	2.7e-06	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.352	1.69e-10	19	297	-0.055	0.00331	NS/NA
ESCA	Esophageal carcinoma	-0.335	2.04e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.388	0.00151	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.133	0.00188	20	522	-0.011	0.0172	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.18	0.00084	24	319	-0.04	2.48e-07	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.22	0.000131	23	275	-0.175	2.54e-06	NS/NA
LAML	Acute Myeloid Leukemia	-0.394	1.37e-07	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.554	0	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.289	2.41e-09	41	373	-0.001	0.00023	NS/NA
LUAD	Lung adenocarcinoma	-0.288	1.69e-10	21	456	-0.053	0.0174	NS/NA
LUSC	Lung squamous cell carcinoma	-0.271	9.58e-08	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.517	0.162	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.392	5.51e-08	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.152	0.0378	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.416	0	35	498	0.332	5.6e-15	Increased
READ	Rectum adenocarcinoma	-0.323	0.00106	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.301	7.7e-07	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.263	7.46e-09	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.359	1.25e-12	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.225	0.00482	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.585	0	50	509	-0.078	2.49e-11	NS/NA
THYM	Thymoma	-0.546	2.34e-11	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.245	9.71e-08	34	431	0.025	2.43e-07	NS/NA

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	3	High
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	3	High
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	3	High
Seminal vesicle	3	High
Skeletal muscle	3	High
Skin	3	High
Small intestine	3	High
Smooth muscle	3	High
Soft tissue	3	High
Spleen	1	Low
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.511	NS	24476821
BRCA	Breast invasive carcinoma	521	3.34e-09	Significant	23000897
COAD	Colon adenocarcinoma	149	1.27e-05	Significant	22810696
GBM	Glioblastoma multiforme	157	7.36e-07	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	1.07e-14	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0608	NS	26536169
LGG	Brain Lower Grade Glioma	513	3.87e-21	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.00476	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.0107	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	2.78e-15	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.0013	Significant	26544944
READ	Rectum adenocarcinoma	67	0.0624	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.0173	Significant	26091043
STAD	Stomach adenocarcinoma	277	0.333	NS	25079317
THCA	Thyroid carcinoma	391	3.43e-36	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	3.5e-05	Significant	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.512	0.0643	NS
BRCA	Breast invasive carcinoma	1079	0.865	0.528	NS
CESC	Cervical and endocervical cancers	291	1.121	0.751	NS
COAD	Colon adenocarcinoma	439	1.462	0.202	NS
ESCA	Esophageal carcinoma	184	0.811	0.526	NS
GBM	Glioblastoma multiforme	158	1.666	0.0425	Shorter
HNSC	Head and Neck squamous cell carcinoma	518	1.033	0.866	NS
KIRC	Kidney renal clear cell carcinoma	531	1.109	0.645	NS
KIRP	Kidney renal papillary cell carcinoma	287	0.708	0.454	NS
LAML	Acute Myeloid Leukemia	149	1.613	0.0917	NS
LGG	Brain Lower Grade Glioma	511	3.619	1.71e-07	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.257	0.37	NS
LUAD	Lung adenocarcinoma	502	1.432	0.105	NS
LUSC	Lung squamous cell carcinoma	494	1.163	0.421	NS
OV	Ovarian serous cystadenocarcinoma	303	0.994	0.974	NS
PAAD	Pancreatic adenocarcinoma	177	2.186	0.00929	Shorter
PCPG	Pheochromocytoma and Paraganglioma	179	552068222.81	0.336	NS
PRAD	Prostate adenocarcinoma	497	0.371	0.243	NS
READ	Rectum adenocarcinoma	159	2.599	0.0832	NS
SARC	Sarcoma	259	1.286	0.357	NS
SKCM	Skin Cutaneous Melanoma	459	1.264	0.23	NS
STAD	Stomach adenocarcinoma	388	1.142	0.562	NS
TGCT	Testicular Germ Cell Tumors	134	0.879	0.927	NS
THCA	Thyroid carcinoma	500	0.485	0.238	NS
THYM	Thymoma	119	3.134	0.336	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.047	0.88	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.09	0.0694	NS
BRCA	Breast invasive carcinoma	1071	-0.002	0.944	NS
CESC	Cervical and endocervical cancers	167	-0.029	0.707	NS
COAD	Colon adenocarcinoma	445	0.055	0.245	NS
ESCA	Esophageal carcinoma	162	-0.238	0.00227	Lower
HNSC	Head and Neck squamous cell carcinoma	448	-0.022	0.646	NS
KIRC	Kidney renal clear cell carcinoma	531	0.02	0.645	NS
KIRP	Kidney renal papillary cell carcinoma	260	-0.055	0.373	NS
LIHC	Liver hepatocellular carcinoma	347	-0.047	0.383	NS
LUAD	Lung adenocarcinoma	507	0.083	0.0618	NS
LUSC	Lung squamous cell carcinoma	497	0.027	0.555	NS
OV	Ovarian serous cystadenocarcinoma	302	0.11	0.0557	NS
PAAD	Pancreatic adenocarcinoma	176	0.191	0.011	Higher
READ	Rectum adenocarcinoma	156	0.069	0.393	NS
SKCM	Skin Cutaneous Melanoma	410	-0.065	0.191	NS
STAD	Stomach adenocarcinoma	392	-0.045	0.374	NS
TGCT	Testicular Germ Cell Tumors	81	0.387	0.000362	Higher
THCA	Thyroid carcinoma	499	0.096	0.0317	Higher
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.062	0.166	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.077	0.207	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.185	3.18e-05	Lower
KIRC	Kidney renal clear cell carcinoma	525	-0.048	0.275	NS
LGG	Brain Lower Grade Glioma	514	0.218	6.39e-07	Higher
LIHC	Liver hepatocellular carcinoma	366	0.184	0.000394	Higher
OV	Ovarian serous cystadenocarcinoma	296	-0.03	0.612	NS
PAAD	Pancreatic adenocarcinoma	176	0.134	0.0768	NS
STAD	Stomach adenocarcinoma	406	-0.077	0.121	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.157	0.000281	Higher

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for LMNA.

Summary
Symbol	LMNA
Name	lamin A/C
Aliases	LMN1; CMD1A; LGMD1B; LMNL1; cardiomyopathy, dilated 1A (autosomal dominant); limb girdle muscular dystrophy ......
Location	1q22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining

[ TOP ]

PMID	Cancer	Hierarchy	Gene	Relation to CR	Evidence
26863915	paediatric haemangiopericytoma-like sarcoma	partner	NTRK1	Fusion	Following detection of a LMNA-NTRK1 gene fusion in an index case of paediatric haemangiopericytoma-like sarcoma by combined whole-genome and RNA sequencing, we identified three additional sarcomas harbouring NTRK1 gene fusions, termed 'spindle cell sarcoma, NOS with myo/haemangiopericytic growth pattern'.
26716414	Colon Carcinoma	partner	NTRK1	Fusion	Here we identified recurrent LMNA-NTRK1 and TPM3-NTRK1 fusions in Korean patients with colon cancer (3 out of 147, 2%) through next-generation RNA sequencing (RNA-seq).
26563355	Colon Carcinoma	partner	NTRK1	Fusion	Molecular characterization unveiled a novel LMNA-NTRK1 rearrangement within chromosome 1 with oncogenic potential, and the patient was treated with the pan-TRK inhibitor entrectinib, achieving partial response with decrease in hepatic target lesions from 6.8 and 8.2cm in longest diameter to 4.7 and 4.3cm, respectively.
26546295	Colorectal Carcinoma	partner	NTRK1	Fusion	A patient with metastatic colorectal cancer harboring an LMNA-NTRK1 rearrangement displayed a remarkable response to treatment with entrectinib, which was followed by the emergence of resistance.
26439802	human Neuroblastoma	partner	MYCN	Negative correlation	We also demonstrates that the development of TICs is due to an increased expression of MYCN gene and that in neuroblastoma exists an inverse relationship between LMNA and MYCN expression.
26216294	soft-tissue sarcoma metastatic to the lung	partner	NTRK1	fusion	The tumor of a 41-year-old woman with soft-tissue sarcoma metastatic to the lung was found to harbor an LMNA-NTRK1 gene fusion encoding a functional LMNA-TRKA fusion oncoprotein as determined by an in situ proximity ligation assay.
26175118	Breast Carcinoma	partner	HER2	Negative correlation	Statistical analysis showed that the frequencies of recurrence and HER2 expression were negatively correlated with lamin A/C expression (P < 0.05), and intrinsic subtype and ki-67 level were associated with nesprin-2 expression (P < 0.05).
28683589	Mesenchymal Cell Neoplasm	partner	NTRK1	Fusion	Using next-generation DNA sequencing, TMP3-NTRK1 fusions were identified in 4 cases, an LMNA-NTRK1 fusion in one case, and a variant EML4-NTRK3 fusion in one case.