CR2Cancer

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF05712 MRG

Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification erase cofactor	Histone acetylation	#	#	12963728

> Gene Ontology [ TOP ]
Biological Process	GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006476 protein deacetylation GO:0016458 gene silencing GO:0016570 histone modification GO:0016573 histone acetylation GO:0016575 histone deacetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0035601 protein deacylation GO:0040029 regulation of gene expression, epigenetic GO:0042692 muscle cell differentiation GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043968 histone H2A acetylation GO:0045814 negative regulation of gene expression, epigenetic GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0098732 macromolecule deacylation
Molecular Function	-
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0031248 protein acetyltransferase complex GO:0035267 NuA4 histone acetyltransferase complex GO:0043189 H4/H2A histone acetyltransferase complex GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM300615	c.255C>T	p.N85N	Substitution - coding silent	Endometrium
COSM5155700	c.577A>G	p.M193V	Substitution - Missense	Large_intestine
COSM1112287	c.533C>T	p.A178V	Substitution - Missense	Endometrium
COSM3405791	c.185G>A	p.R62H	Substitution - Missense	Central_nervous_system
COSM754851	c.88C>T	p.Q30*	Substitution - Nonsense	Lung
COSM5884927	c.199C>T	p.P67S	Substitution - Missense	Skin
COSM1472277	c.321C>T	p.P107P	Substitution - coding silent	Prostate
COSM403571	c.219G>T	p.R73S	Substitution - Missense	Liver
COSM1112290	c.353G>T	p.R118I	Substitution - Missense	Endometrium
COSM3405791	c.185G>A	p.R62H	Substitution - Missense	Central_nervous_system
COSM5029886	c.179G>C	p.G60A	Substitution - Missense	Bone
COSM1625330	c.227G>C	p.R76T	Substitution - Missense	Liver
COSM1112291	c.285T>G	p.P95P	Substitution - coding silent	Endometrium
COSM754854	c.854G>A	p.R285H	Substitution - Missense	Lung
COSM754852	c.311G>T	p.R104L	Substitution - Missense	Lung
COSM3556125	c.119G>A	p.G40E	Substitution - Missense	Skin
COSM269612	c.827A>G	p.Y276C	Substitution - Missense	Large_intestine
COSM4792077	c.821G>A	p.S274N	Substitution - Missense	Liver
COSM403571	c.219G>T	p.R73S	Substitution - Missense	Lung
COSM3913118	c.34G>A	p.G12R	Substitution - Missense	Skin
COSM2735201	c.271A>G	p.T91A	Substitution - Missense	Central_nervous_system
COSM3843076	c.680A>C	p.H227P	Substitution - Missense	Breast
COSM5823219	c.541G>A	p.E181K	Substitution - Missense	Liver
COSM5411600	c.195G>A	p.E65E	Substitution - coding silent	Skin
COSM298472	c.614C>T	p.P205L	Substitution - Missense	Large_intestine
COSM1497093	c.304A>G	p.R102G	Substitution - Missense	Kidney
COSM4186059	c.578T>C	p.M193T	Substitution - Missense	Kidney
COSM456389	c.834G>T	p.V278V	Substitution - coding silent	Breast
COSM1580253	c.725C>T	p.T242M	Substitution - Missense	Central_nervous_system
COSM754853	c.494G>A	p.C165Y	Substitution - Missense	Lung
COSM5734332	c.295C>T	p.R99W	Substitution - Missense	Pancreas
COSM300615	c.255C>T	p.N85N	Substitution - coding silent	Large_intestine
COSM5715994	c.660C>T	p.S220S	Substitution - coding silent	Skin
COSM5436078	c.671G>A	p.G224E	Substitution - Missense	Oesophagus
COSM373443	c.403G>A	p.E135K	Substitution - Missense	Lung
COSM4105510	c.378T>G	p.P126P	Substitution - coding silent	Stomach
COSM220220	c.676C>T	p.P226S	Substitution - Missense	Haematopoietic_and_lymphoid_tissue
COSM1158877	c.615C>T	p.P205P	Substitution - coding silent	Pancreas
COSM3371988	c.481G>A	p.E161K	Substitution - Missense	Thyroid
COSM5153613	c.469G>A	p.A157T	Substitution - Missense	Large_intestine
COSM3939714	c.90G>A	p.Q30Q	Substitution - coding silent	Oesophagus
COSM5715994	c.660C>T	p.S220S	Substitution - coding silent	Skin
COSM1464555	c.69delA	p.K23fs*12	Deletion - Frameshift	Large_intestine
COSM1625330	c.227G>C	p.R76T	Substitution - Missense	Liver
COSM370644	c.756G>T	p.L252F	Substitution - Missense	Lung
COSM212759	c.707G>T	p.G236V	Substitution - Missense	Breast
COSM3843077	c.641A>C	p.H214P	Substitution - Missense	Breast
COSM1112286	c.631C>A	p.L211I	Substitution - Missense	Endometrium
COSM4792077	c.821G>A	p.S274N	Substitution - Missense	Liver
COSM1331398	c.722A>C	p.Y241S	Substitution - Missense	Ovary
COSM3973067	c.100A>G	p.M34V	Substitution - Missense	Central_nervous_system
COSM5977364	c.233A>G	p.N78S	Substitution - Missense	Upper_aerodigestive_tract
COSM276101	c.504G>A	p.S168S	Substitution - coding silent	Large_intestine
COSM5725279	c.11G>A	p.R4K	Substitution - Missense	Skin
COSM1112288	c.509G>A	p.G170E	Substitution - Missense	Endometrium
COSM5725279	c.11G>A	p.R4K	Substitution - Missense	Skin
COSM5728981	c.266G>A	p.G89D	Substitution - Missense	Skin
COSM1158877	c.615C>T	p.P205P	Substitution - coding silent	Pancreas
COSM5715994	c.660C>T	p.S220S	Substitution - coding silent	Skin
COSM1315087	c.753A>G	p.L251L	Substitution - coding silent	Urinary_tract
COSM5715994	c.660C>T	p.S220S	Substitution - coding silent	Skin
COSM1112289	c.503C>T	p.S168L	Substitution - Missense	Endometrium
COSM3843078	c.589C>T	p.Q197*	Substitution - Nonsense	Breast
COSM1112292	c.91A>G	p.R31G	Substitution - Missense	Endometrium
COSM1112285	c.842C>A	p.A281D	Substitution - Missense	Endometrium

> Text Mining based Variations [ TOP ]
There is no record for MORF4L2.

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	7.667	7.918	0.253	0.0499	NS
BRCA	Breast invasive carcinoma	112	1100	7.553	8.308	0.795	2.06e-38	Over
CESC	Cervical and endocervical cancers	3	306	8.481	7.902	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	7.091	7.825	0.645	1.9e-11	Over
ESCA	Esophageal carcinoma	11	185	7.248	7.667	0.349	0.0379	NS
GBM	Glioblastoma multiforme	5	166	8.426	7.949	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	7.418	7.616	0.241	0.00233	NS
KIRC	Kidney renal clear cell carcinoma	72	534	7.387	7.541	0.184	1.83e-05	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	7.191	7.284	0.146	0.0865	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.923	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	7.634	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	7.066	7.193	0.162	0.042	NS
LUAD	Lung adenocarcinoma	59	517	7.194	7.826	0.563	6.09e-15	NS
LUSC	Lung squamous cell carcinoma	51	501	7.211	7.886	0.689	1.12e-18	Over
OV	Ovarian serous cystadenocarcinoma	0	307	NA	7.938	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	7.439	7.553	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	8.382	8.525	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	7.835	7.81	-0.138	0.00357	NS
READ	Rectum adenocarcinoma	10	167	7.413	7.877	0.378	0.095	NS
SARC	Sarcoma	2	263	7.504	8.173	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	6.535	7.842	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	7.252	7.574	0.337	7.84e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	7.825	NA	NA	NA
THCA	Thyroid carcinoma	59	509	7.828	7.623	-0.187	4.54e-07	NS
THYM	Thymoma	2	120	6.887	7.142	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	8.107	7.855	-0.416	1.14e-05	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	141.7
Adrenal gland	236.8
Appendix	143
Bone marrow	63.8
Breast	226.8
Cerebral cortex	288.3
Cervix, uterine	387.7
Colon	123.3
Duodenum	98.2
Endometrium	419.8
Epididymis	261.9
Esophagus	159
Fallopian tube	306.3
Gallbladder	224.8
Heart muscle	93.4
Kidney	139.6
Liver	105.1
Lung	147.2
Lymph node	91
Ovary	387.8
Pancreas	21.7
Parathyroid gland	210.5
Placenta	354.8
Prostate	273.5
Rectum	160
Salivary gland	54
Seminal vesicle	270.7
Skeletal muscle	64.2
Skin	119.6
Small intestine	117.5
Smooth muscle	488.6
Spleen	118.2
Stomach	110.2
Testis	171.1
Thyroid gland	278.7
Tonsil	108.3
Urinary bladder	187.4

> Text Mining based Expression

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PMID	Expression	Cancer	Evidence
25947577	Overexpression	Neuroendocrine Neoplasm	Progressive disease was identified by elevated levels of a quotient of MORF4L2 expression and SUVmax [ROC-derived AUC (R (2)=0.7, p<0.05)].

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.255	2.05e-07	18.3	66.8	14.9	Neutral
BRCA	Breast invasive carcinoma	1075	0.136	7.21e-06	20.2	67.8	12	Neutral
CESC	Cervical and endocervical cancers	292	0.271	2.55e-06	18.8	64.4	16.8	Neutral
COAD	Colon adenocarcinoma	449	0.067	0.155	12	71.7	16.3	Neutral
ESCA	Esophageal carcinoma	183	0.278	0.000138	17.5	54.1	28.4	Neutral
GBM	Glioblastoma multiforme	147	0.09	0.278	22.4	72.1	5.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.38	4.68e-19	12.3	64.6	23.2	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.084	0.0547	9.3	85.5	5.1	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.293	4.11e-07	10.4	55.2	34.4	Gain
LAML	Acute Myeloid Leukemia	166	-0.056	0.475	3.6	95.8	0.6	Neutral
LGG	Brain Lower Grade Glioma	513	-0.001	0.991	13.3	76.8	9.9	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.449	1.91e-19	16.8	63.5	19.8	Neutral
LUAD	Lung adenocarcinoma	512	0.375	1.53e-18	13.3	67.4	19.3	Neutral
LUSC	Lung squamous cell carcinoma	498	0.428	1.19e-23	20.1	58.8	21.1	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.117	0.0421	46.3	32.7	21	Loss
PAAD	Pancreatic adenocarcinoma	177	0.282	0.000143	11.3	80.2	8.5	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.062	0.437	30.9	66	3.1	Neutral
PRAD	Prostate adenocarcinoma	491	-0.109	0.0159	6.9	90.4	2.6	Neutral
READ	Rectum adenocarcinoma	164	0.238	0.00215	16.5	64.6	18.9	Neutral
SARC	Sarcoma	255	0.288	2.97e-06	46.7	42	11.4	Loss
SKCM	Skin Cutaneous Melanoma	367	0.017	0.742	25.3	61.9	12.8	Neutral
STAD	Stomach adenocarcinoma	413	0.292	1.43e-09	11.4	73.4	15.3	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.192	0.0183	16.7	66.7	16.7	Neutral
THCA	Thyroid carcinoma	497	0.016	0.72	0.8	97.6	1.6	Neutral
THYM	Thymoma	119	0.129	0.162	4.2	92.4	3.4	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.132	0.00225	12.8	73.4	13.8	Neutral

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.249	2.31e-07	17	408	-0.007	0.448	NS/NA
BRCA	Breast invasive carcinoma	-0.303	7.21e-20	83	785	-0.097	2.33e-30	NS/NA
CESC	Cervical and endocervical cancers	-0.168	0.00305	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.205	0.000251	19	297	-0.004	0.688	NS/NA
ESCA	Esophageal carcinoma	-0.327	3.7e-06	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.198	0.114	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.121	0.0049	20	522	-0.043	0.112	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.133	0.014	24	319	0.031	1.74e-05	NS/NA
KIRP	Kidney renal papillary cell carcinoma	0.015	0.799	23	275	0.003	0.00494	NS/NA
LAML	Acute Myeloid Leukemia	-0.064	0.406	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.09	0.0375	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.256	1.35e-07	41	373	0.01	0.0748	NS/NA
LUAD	Lung adenocarcinoma	-0.177	0.000109	21	456	0.121	0.508	NS/NA
LUSC	Lung squamous cell carcinoma	-0.169	0.000975	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.783	0.0172	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.145	0.0504	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.105	0.151	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.106	0.0139	35	498	-0.098	0.0369	NS/NA
READ	Rectum adenocarcinoma	-0.333	0.000702	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.281	3.93e-06	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.228	6.03e-07	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.22	1.88e-05	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.423	5.25e-08	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.001	0.978	50	509	-0.029	3.94e-06	NS/NA
THYM	Thymoma	-0.098	0.281	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.187	4.89e-05	34	431	0.026	0.184	NS/NA

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	3	High
Appendix	3	High
Bone marrow	3	High
Breast	3	High
Bronchus	3	High
Caudate	3	High
Cerebellum	3	High
Cerebral cortex	3	High
Cervix, uterine	3	High
Colon	3	High
Duodenum	3	High
Endometrium	3	High
Epididymis	3	High
Esophagus	3	High
Fallopian tube	3	High
Gallbladder	3	High
Heart muscle	3	High
Hippocampus	3	High
Kidney	3	High
Liver	2	Medium
Lung	3	High
Lymph node	3	High
Nasopharynx	3	High
Oral mucosa	3	High
Ovary	2	Medium
Pancreas	3	High
Parathyroid gland	3	High
Placenta	3	High
Prostate	3	High
Rectum	3	High
Salivary gland	2	Medium
Seminal vesicle	3	High
Skeletal muscle	2	Medium
Skin	3	High
Small intestine	3	High
Smooth muscle	2	Medium
Soft tissue	3	High
Spleen	2	Medium
Stomach	3	High
Testis	3	High
Thyroid gland	3	High
Tonsil	3	High
Urinary bladder	3	High
Vagina	3	High

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

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Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.629	NS	24476821
BRCA	Breast invasive carcinoma	521	2.53e-10	Significant	23000897
COAD	Colon adenocarcinoma	149	0.39	NS	22810696
GBM	Glioblastoma multiforme	157	0.000335	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	4.36e-13	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	5.21e-07	Significant	26536169
LGG	Brain Lower Grade Glioma	513	2.59e-07	Significant	26824661
LUAD	Lung adenocarcinoma	230	2.79e-05	Significant	25079552
LUSC	Lung squamous cell carcinoma	178	0.00232	Significant	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.274	NS	21720365
PRAD	Prostate adenocarcinoma	333	5.39e-05	Significant	26544944
READ	Rectum adenocarcinoma	67	0.8	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.177	NS	26091043
STAD	Stomach adenocarcinoma	277	1.6e-06	Significant	25079317
THCA	Thyroid carcinoma	391	0.0206	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.89	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	1.131	0.567	NS
BRCA	Breast invasive carcinoma	1079	2.702	0.000126	Shorter
CESC	Cervical and endocervical cancers	291	1.056	0.874	NS
COAD	Colon adenocarcinoma	439	0.952	0.859	NS
ESCA	Esophageal carcinoma	184	2.899	0.0012	Shorter
GBM	Glioblastoma multiforme	158	0.808	0.416	NS
HNSC	Head and Neck squamous cell carcinoma	518	1.999	0.000697	Shorter
KIRC	Kidney renal clear cell carcinoma	531	1.038	0.855	NS
KIRP	Kidney renal papillary cell carcinoma	287	3.476	0.00203	Shorter
LAML	Acute Myeloid Leukemia	149	0.59	0.0759	NS
LGG	Brain Lower Grade Glioma	511	0.784	0.322	NS
LIHC	Liver hepatocellular carcinoma	365	0.944	0.808	NS
LUAD	Lung adenocarcinoma	502	1.399	0.107	NS
LUSC	Lung squamous cell carcinoma	494	1.227	0.318	NS
OV	Ovarian serous cystadenocarcinoma	303	0.739	0.143	NS
PAAD	Pancreatic adenocarcinoma	177	1.04	0.902	NS
PCPG	Pheochromocytoma and Paraganglioma	179	1.44	0.688	NS
PRAD	Prostate adenocarcinoma	497	2.113	0.285	NS
READ	Rectum adenocarcinoma	159	2.5	0.176	NS
SARC	Sarcoma	259	1.593	0.12	NS
SKCM	Skin Cutaneous Melanoma	459	0.785	0.205	NS
STAD	Stomach adenocarcinoma	388	0.975	0.915	NS
TGCT	Testicular Germ Cell Tumors	134	0	0.281	NS
THCA	Thyroid carcinoma	500	0.614	0.401	NS
THYM	Thymoma	119	3.127	0.299	NS
UCEC	Uterine Corpus Endometrial Carcinoma	543	2.53	0.00184	Shorter

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	0.071	0.154	NS
BRCA	Breast invasive carcinoma	1071	0.065	0.0347	Higher
CESC	Cervical and endocervical cancers	167	-0.035	0.651	NS
COAD	Colon adenocarcinoma	445	-0.047	0.319	NS
ESCA	Esophageal carcinoma	162	0.149	0.0592	NS
HNSC	Head and Neck squamous cell carcinoma	448	0.057	0.232	NS
KIRC	Kidney renal clear cell carcinoma	531	0.203	2.47e-06	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.32	1.39e-07	Higher
LIHC	Liver hepatocellular carcinoma	347	0.014	0.802	NS
LUAD	Lung adenocarcinoma	507	0.076	0.0864	NS
LUSC	Lung squamous cell carcinoma	497	0.08	0.0752	NS
OV	Ovarian serous cystadenocarcinoma	302	-0.005	0.931	NS
PAAD	Pancreatic adenocarcinoma	176	-0.066	0.383	NS
READ	Rectum adenocarcinoma	156	0.001	0.989	NS
SKCM	Skin Cutaneous Melanoma	410	0.024	0.63	NS
STAD	Stomach adenocarcinoma	392	-0.024	0.636	NS
TGCT	Testicular Germ Cell Tumors	81	0.215	0.0541	NS
THCA	Thyroid carcinoma	499	-0.044	0.331	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	0.037	0.41	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	-0.01	0.867	NS
HNSC	Head and Neck squamous cell carcinoma	498	-0.068	0.127	NS
KIRC	Kidney renal clear cell carcinoma	525	0.153	0.000429	Higher
LGG	Brain Lower Grade Glioma	514	-0.054	0.224	NS
LIHC	Liver hepatocellular carcinoma	366	-0.054	0.306	NS
OV	Ovarian serous cystadenocarcinoma	296	-0.044	0.448	NS
PAAD	Pancreatic adenocarcinoma	176	-0.025	0.744	NS
STAD	Stomach adenocarcinoma	406	-0.154	0.00181	Lower
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.135	0.00174	Higher

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for MORF4L2.

Summary
Symbol	MORF4L2
Name	mortality factor 4 like 2
Aliases	KIAA0026; MRGX; MORF-related gene X; MORFL2; MORF-related gene X protein; MSL3-2 protein; protein MSL3-2; tr ......
Location	Xq22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for MORF4L2.