CR2Cancer

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Domain, Function and Classification > Gene Ontology > KEGG and Reactome Pathway

> Domain, Function and Classification

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Domain

PF05712 MRG
PF11717 RNA binding activity-knot of a chromodomain

Function

May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.

Classification

Class	Modification	Substrate	Product	PubMed
Histone modification read	#	H4K20me1	#	20943666

> Gene Ontology [ TOP ]
Biological Process	GO:0006338 chromatin remodeling GO:0006342 chromatin silencing GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006476 protein deacetylation GO:0016458 gene silencing GO:0016570 histone modification GO:0016573 histone acetylation GO:0016575 histone deacetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0035601 protein deacylation GO:0040029 regulation of gene expression, epigenetic GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043968 histone H2A acetylation GO:0043984 histone H4-K16 acetylation GO:0045814 negative regulation of gene expression, epigenetic GO:0098732 macromolecule deacylation
Molecular Function	GO:0035064 methylated histone binding GO:0042393 histone binding
Cellular Component	GO:0000123 histone acetyltransferase complex GO:0031248 protein acetyltransferase complex GO:0035267 NuA4 histone acetyltransferase complex GO:0043189 H4/H2A histone acetyltransferase complex GO:0072487 MSL complex GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Mutation landscape in primary tumor tissue from TCGA > Mutation landscape in cancer cell line from CCLE > All mutations from COSMIC database V81 > Variations from text mining

> The Cancer Genome Atlas (TCGA) [ TOP ]

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> Catalogue of Somatic Mutations in Cancer (COSMIC)

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COSMIC ID	CDS change	AA change	Mutation Type	Anatomical Site
COSM1714630	c.877C>T	p.P293S	Substitution - Missense	Skin
COSM305396	c.417G>A	p.K139K	Substitution - coding silent	Central_nervous_system
COSM4465594	c.1390C>T	p.P464S	Substitution - Missense	Skin
COSM1465094	c.56G>A	p.C19Y	Substitution - Missense	Large_intestine
COSM4703391	c.935C>T	p.P312L	Substitution - Missense	Large_intestine
COSM1113687	c.235A>C	p.N79H	Substitution - Missense	Endometrium
COSM2723163	c.1373G>A	p.R458Q	Substitution - Missense	Large_intestine
COSM1465106	c.1055C>T	p.T352M	Substitution - Missense	Large_intestine
COSM5064297	c.565T>C	p.Y189H	Substitution - Missense	Stomach
COSM2723128	c.792C>A	p.T264T	Substitution - coding silent	Large_intestine
COSM3701785	c.315G>A	p.R105R	Substitution - coding silent	Liver
COSM5499532	c.1483C>T	p.H495Y	Substitution - Missense	Biliary_tract
COSM3405872	c.1357G>A	p.A453T	Substitution - Missense	Central_nervous_system
COSM5887164	c.860C>T	p.S287L	Substitution - Missense	Skin
COSM1113699	c.731A>C	p.Y244S	Substitution - Missense	Endometrium
COSM3557170	c.1284C>T	p.V428V	Substitution - coding silent	Skin
COSM456578	c.1012C>T	p.R338C	Substitution - Missense	Breast
COSM5696726	c.1230G>T	p.G410G	Substitution - coding silent	Soft_tissue
COSM5903293	c.770T>G	p.M257R	Substitution - Missense	Skin
COSM754465	c.1057C>T	p.R353C	Substitution - Missense	Lung
COSM1465096	c.308G>A	p.R103H	Substitution - Missense	Large_intestine
COSM3843343	c.1383G>A	p.V461V	Substitution - coding silent	Breast
COSM1113702	c.747G>T	p.K249N	Substitution - Missense	Endometrium
COSM1113729	c.1494C>A	p.F498L	Substitution - Missense	Endometrium
COSM1113713	c.1262G>T	p.R421I	Substitution - Missense	Endometrium
COSM5894726	c.998C>G	p.A333G	Substitution - Missense	Skin
COSM754471	c.543G>C	p.K181N	Substitution - Missense	Lung
COSM754464	c.1193C>A	p.S398*	Substitution - Nonsense	Lung
COSM1582858	c.466-1G>C	p.?	Unknown	Meninges
COSM282891	c.542A>C	p.K181T	Substitution - Missense	Large_intestine
COSM1662866	c.250C>T	p.R84C	Substitution - Missense	Kidney
COSM1465113	c.1314delC	p.P440fs*22	Deletion - Frameshift	Large_intestine
COSM4106122	c.1538G>A	p.S513N	Substitution - Missense	Stomach
COSM5178321	c.842A>G	p.Q281R	Substitution - Missense	Large_intestine
COSM4703388	c.475C>T	p.P159S	Substitution - Missense	Large_intestine
COSM300783	c.1550C>T	p.P517L	Substitution - Missense	Large_intestine
COSM3843335	c.765G>A	p.K255K	Substitution - coding silent	Breast
COSM2723163	c.1373G>A	p.R458Q	Substitution - Missense	Large_intestine
COSM462332	c.1383G>T	p.V461V	Substitution - coding silent	Cervix
COSM5699493	c.190G>T	p.D64Y	Substitution - Missense	Soft_tissue
COSM5666835	c.1279G>C	p.E427Q	Substitution - Missense	Soft_tissue
COSM1113710	c.866A>C	p.K289T	Substitution - Missense	Endometrium
COSM5938523	c.346C>T	p.L116F	Substitution - Missense	Skin
COSM4654531	c.1254A>G	p.E418E	Substitution - coding silent	Large_intestine
COSM422256	c.1171A>G	p.K391E	Substitution - Missense	Urinary_tract
COSM3843341	c.1279G>A	p.E427K	Substitution - Missense	Breast
COSM3694290	c.277C>T	p.R93C	Substitution - Missense	Large_intestine
COSM4106110	c.957G>A	p.T319T	Substitution - coding silent	Stomach
COSM1756349	c.1118G>A	p.R373Q	Substitution - Missense	Urinary_tract
COSM2723136	c.1064G>A	p.S355N	Substitution - Missense	Large_intestine
COSM282893	c.1425G>T	p.K475N	Substitution - Missense	Large_intestine
COSM6005322	c.60C>T	p.F20F	Substitution - coding silent	Prostate
COSM1465110	c.1058G>A	p.R353H	Substitution - Missense	Large_intestine
COSM5042624	c.1303C>T	p.P435S	Substitution - Missense	Liver
COSM5515810	c.1089G>T	p.E363D	Substitution - Missense	Biliary_tract
COSM2157140	c.1282-1G>A	p.?	Unknown	Central_nervous_system
COSM1113731	c.1502A>C	p.E501A	Substitution - Missense	Endometrium
COSM6018346	c.367G>A	p.E123K	Substitution - Missense	Skin
COSM356301	c.395C>G	p.S132C	Substitution - Missense	Lung
COSM2155367	c.789A>G	p.I263M	Substitution - Missense	Central_nervous_system
COSM3557162	c.886G>A	p.E296K	Substitution - Missense	Skin
COSM1113694	c.555G>A	p.E185E	Substitution - coding silent	Endometrium
COSM1729663	c.412A>C	p.N138H	Substitution - Missense	Liver
COSM3843338	c.766G>T	p.E256*	Substitution - Nonsense	Breast
COSM1465108	c.1056G>A	p.T352T	Substitution - coding silent	Large_intestine
COSM1756349	c.1118G>A	p.R373Q	Substitution - Missense	Urinary_tract
COSM4106100	c.337T>A	p.L113I	Substitution - Missense	Stomach
COSM5646970	c.409G>C	p.E137Q	Substitution - Missense	Oesophagus
COSM2723089	c.275C>A	p.A92D	Substitution - Missense	Upper_aerodigestive_tract
COSM2157140	c.1282-1G>A	p.?	Unknown	Central_nervous_system
COSM5966514	c.1057C>A	p.R353S	Substitution - Missense	Adrenal_gland
COSM1113682	c.103-1G>C	p.?	Unknown	Endometrium
COSM5155686	c.731A>G	p.Y244C	Substitution - Missense	Large_intestine
COSM5411853	c.582G>A	p.R194R	Substitution - coding silent	Skin
COSM456574	c.223G>A	p.D75N	Substitution - Missense	Breast
COSM3557172	c.1398C>T	p.I466I	Substitution - coding silent	Skin
COSM456580	c.1042C>T	p.L348L	Substitution - coding silent	Breast
COSM2723136	c.1064G>A	p.S355N	Substitution - Missense	Large_intestine
COSM216175	c.1175C>T	p.T392I	Substitution - Missense	Central_nervous_system
COSM1662866	c.250C>T	p.R84C	Substitution - Missense	Stomach
COSM456578	c.1012C>T	p.R338C	Substitution - Missense	Large_intestine
COSM4106113	c.1196C>T	p.S399F	Substitution - Missense	Stomach
COSM5519839	c.355G>A	p.E119K	Substitution - Missense	Biliary_tract
COSM360592	c.1474G>T	p.A492S	Substitution - Missense	Lung
COSM4106105	c.614A>G	p.N205S	Substitution - Missense	Stomach
COSM2723132	c.865delA	p.K289fs*27	Deletion - Frameshift	Large_intestine
COSM1257991	c.1372C>A	p.R458R	Substitution - coding silent	Stomach
COSM4916502	c.949C>A	p.P317T	Substitution - Missense	Liver
COSM1465103	c.867A>T	p.K289N	Substitution - Missense	Large_intestine
COSM1625436	c.258G>T	p.L86F	Substitution - Missense	Liver
COSM1569747	c.956C>T	p.T319M	Substitution - Missense	Large_intestine
COSM1714630	c.877C>T	p.P293S	Substitution - Missense	Skin
COSM3843331	c.394T>C	p.S132P	Substitution - Missense	Breast
COSM1743816	c.520A>G	p.I174V	Substitution - Missense	Biliary_tract
COSM4589128	c.119T>C	p.V40A	Substitution - Missense	Bone
COSM355879	c.1058G>C	p.R353P	Substitution - Missense	Lung
COSM487855	c.1308C>T	p.D436D	Substitution - coding silent	Kidney
COSM5779943	c.1165G>C	p.E389Q	Substitution - Missense	Breast
COSM75467	c.757C>T	p.L253F	Substitution - Missense	Ovary
COSM4106097	c.307C>T	p.R103C	Substitution - Missense	Stomach
COSM3424379	c.167T>G	p.F56C	Substitution - Missense	Large_intestine
COSM5411850	c.238C>T	p.R80C	Substitution - Missense	Skin
COSM5611618	c.102G>T	p.K34N	Substitution - Missense	Adrenal_gland
COSM4546876	c.409G>A	p.E137K	Substitution - Missense	Skin
COSM487852	c.1126G>A	p.D376N	Substitution - Missense	Kidney
COSM487854	c.1228G>T	p.G410W	Substitution - Missense	Kidney
COSM3843328	c.336C>G	p.V112V	Substitution - coding silent	Breast
COSM3716540	c.239G>A	p.R80H	Substitution - Missense	Prostate
COSM4106091	c.192T>C	p.D64D	Substitution - coding silent	Stomach
COSM216175	c.1175C>T	p.T392I	Substitution - Missense	Central_nervous_system

> Text Mining based Variations [ TOP ]
There is no record for MSL3.

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Post-translational modification (PTM)

> Post-translational modification (PTM)

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Filter By:

Uniprot ID	Position	Amino Acid	Description	Upstream Enzyme	Affected By Mutation	Amino Acid Sequence Variant
Q8N5Y2	311	S	Phosphoserine	-	No	None detected
Q8N5Y2	367	S	Phosphoserine	-	No	None detected
Q8N5Y2	400	S	Phosphoserine	-	No	None detected
Q8N5Y2	405	T	Phosphothreonine	-	No	None detected
Q8N5Y2	407	S	Phosphoserine	-	No	None detected
Q8N5Y2	411	S	Phosphoserine	-	No	None detected

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Expression analysis in primary tumor tissue from TCGA > Expression level in cancer cell line from CCLE > Expression level in human normal tissue from HPA > Text mining based expression change

> The Cancer Genome Atlas (TCGA)

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Differential expression analysis for cancers with more than 10 normal samples

Cancer	Full Name	# N	# T	Median (N)	Median (T)	LogFC	Adj. P	Status
BLCA	Bladder urothelial carcinoma	19	408	4.652	5.029	0.309	0.00646	NS
BRCA	Breast invasive carcinoma	112	1100	4.904	4.814	-0.008	0.889	NS
CESC	Cervical and endocervical cancers	3	306	4.285	5.224	NA	NA	NA
COAD	Colon adenocarcinoma	41	459	4.501	4.922	0.383	1.86e-06	NS
ESCA	Esophageal carcinoma	11	185	4.534	4.882	0.256	0.141	NS
GBM	Glioblastoma multiforme	5	166	5.301	5.077	NA	NA	NA
HNSC	Head and Neck squamous cell carcinoma	44	522	4.749	4.665	-0.019	0.822	NS
KIRC	Kidney renal clear cell carcinoma	72	534	4.284	4.712	0.431	4.85e-21	NS
KIRP	Kidney renal papillary cell carcinoma	32	291	4.144	4.419	0.265	1.81e-05	NS
LAML	Acute Myeloid Leukemia	0	173	NA	6.245	NA	NA	NA
LGG	Brain Lower Grade Glioma	0	530	NA	4.759	NA	NA	NA
LIHC	Liver hepatocellular carcinoma	50	373	3.433	3.54	0.091	0.151	NS
LUAD	Lung adenocarcinoma	59	517	4.906	4.862	-0.042	0.485	NS
LUSC	Lung squamous cell carcinoma	51	501	4.866	4.92	0.067	0.36	NS
OV	Ovarian serous cystadenocarcinoma	0	307	NA	5.145	NA	NA	NA
PAAD	Pancreatic adenocarcinoma	4	179	5.094	4.687	NA	NA	NA
PCPG	Pheochromocytoma and Paraganglioma	3	184	4.231	4.209	NA	NA	NA
PRAD	Prostate adenocarcinoma	52	498	4.32	4.519	0.225	4.31e-05	NS
READ	Rectum adenocarcinoma	10	167	4.55	4.976	0.399	0.0224	NS
SARC	Sarcoma	2	263	4.304	4.986	NA	NA	NA
SKCM	Skin Cutaneous Melanoma	1	472	5.355	4.658	NA	NA	NA
STAD	Stomach adenocarcinoma	35	415	4.51	4.994	0.334	5.78e-05	NS
TGCT	Testicular Germ Cell Tumors	0	156	NA	5.202	NA	NA	NA
THCA	Thyroid carcinoma	59	509	4.453	4.602	0.081	0.0545	NS
THYM	Thymoma	2	120	6.3	5.503	NA	NA	NA
UCEC	Uterine Corpus Endometrial Carcinoma	35	546	4.539	4.931	0.368	2.04e-05	NS

> Cancer Cell Line Encyclopedia (CCLE) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

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Tissue	Expression Level (TPM)
Adipose tissue	17.5
Adrenal gland	14.5
Appendix	49.8
Bone marrow	20.1
Breast	18.7
Cerebral cortex	25.4
Cervix, uterine	15.9
Colon	12.1
Duodenum	13.1
Endometrium	20.3
Epididymis	12.3
Esophagus	16.6
Fallopian tube	17.4
Gallbladder	24.5
Heart muscle	6.9
Kidney	9.2
Liver	6
Lung	24.1
Lymph node	60.6
Ovary	12.2
Pancreas	1.6
Parathyroid gland	15.2
Placenta	20.1
Prostate	17.2
Rectum	16.4
Salivary gland	4.8
Seminal vesicle	16.6
Skeletal muscle	13.6
Skin	23.7
Small intestine	15
Smooth muscle	20.8
Spleen	44.3
Stomach	13.2
Testis	29.5
Thyroid gland	19.7
Tonsil	38.2
Urinary bladder	24.6

> Text Mining based Expression [ TOP ]
There is no record.

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Somatic copy number alteration in primary tomur tissue

> The Cancer Genome Atlas (TCGA)

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Correlation between expression and SCNA as well as percentage of patients in different status.

Cancer	Full Name	# Sample	R	P	% Loss	% Neutral	% Gain	Status
BLCA	Bladder urothelial carcinoma	404	0.396	1.16e-16	19.6	62.1	18.3	Neutral
BRCA	Breast invasive carcinoma	1075	0.199	4.34e-11	18.6	64.5	16.9	Neutral
CESC	Cervical and endocervical cancers	292	0.284	8.01e-07	20.9	60.6	18.5	Neutral
COAD	Colon adenocarcinoma	449	0.276	2.73e-09	14.9	68.2	16.9	Neutral
ESCA	Esophageal carcinoma	183	0.58	7.32e-18	34.4	49.2	16.4	Loss
GBM	Glioblastoma multiforme	147	0.613	1.57e-16	27.2	67.3	5.4	Neutral
HNSC	Head and Neck squamous cell carcinoma	514	0.462	1.65e-28	29.4	61.7	8.9	Neutral
KIRC	Kidney renal clear cell carcinoma	525	0.167	0.00012	10.3	84.4	5.3	Neutral
KIRP	Kidney renal papillary cell carcinoma	288	-0.044	0.453	11.8	58	30.2	Neutral
LAML	Acute Myeloid Leukemia	166	0.071	0.363	3	95.8	1.2	Neutral
LGG	Brain Lower Grade Glioma	513	0.281	9.77e-11	21.2	73.5	5.3	Neutral
LIHC	Liver hepatocellular carcinoma	364	0.221	2.13e-05	29.7	59.9	10.4	Neutral
LUAD	Lung adenocarcinoma	512	0.317	2.18e-13	26.8	62.5	10.7	Neutral
LUSC	Lung squamous cell carcinoma	498	0.514	7.4e-35	29.9	54.8	15.3	Neutral
OV	Ovarian serous cystadenocarcinoma	300	0.414	7.89e-14	57	25.7	17.3	Loss
PAAD	Pancreatic adenocarcinoma	177	0.21	0.00504	14.7	80.2	5.1	Neutral
PCPG	Pheochromocytoma and Paraganglioma	162	0.232	0.003	27.8	67.3	4.9	Neutral
PRAD	Prostate adenocarcinoma	491	0.218	1.06e-06	5.1	90.2	4.7	Neutral
READ	Rectum adenocarcinoma	164	0.319	3.12e-05	18.3	62.8	18.9	Neutral
SARC	Sarcoma	255	0.445	8.21e-14	25.1	42.4	32.5	Neutral
SKCM	Skin Cutaneous Melanoma	367	0.132	0.0112	22.9	62.1	15	Neutral
STAD	Stomach adenocarcinoma	413	0.374	4.04e-15	15.5	68.5	16	Neutral
TGCT	Testicular Germ Cell Tumors	150	0.244	0.00265	18.7	62.7	18.7	Neutral
THCA	Thyroid carcinoma	497	-0.007	0.883	0.8	97.4	1.8	Neutral
THYM	Thymoma	119	0.177	0.0535	6.7	91.6	1.7	Neutral
UCEC	Uterine Corpus Endometrial Carcinoma	537	0.171	6.92e-05	14.7	70.4	14.9	Neutral

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Methylation level in the promoter region of CR

> Methylation level in the promoter region of CR

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Correlation between expression and methylation as well as differential methylation analysis.

Cancer	Full Name	R	P	# N	# T	Delta beta (T vs N)	P value (T vs N)	Status
BLCA	Bladder urothelial carcinoma	-0.125	0.00987	17	408	-0.259	6e-09	Decreased
BRCA	Breast invasive carcinoma	-0.29	3.5e-18	83	785	-0.015	0.504	NS/NA
CESC	Cervical and endocervical cancers	-0.233	3.64e-05	3	306	NA	NA	NS/NA
COAD	Colon adenocarcinoma	-0.238	1.94e-05	19	297	-0.22	7.11e-24	Decreased
ESCA	Esophageal carcinoma	-0.236	0.000928	9	185	NA	NA	NS/NA
GBM	Glioblastoma multiforme	-0.379	0.002	1	64	NA	NA	NS/NA
HNSC	Head and Neck squamous cell carcinoma	-0.11	0.0103	20	522	-0.011	0.313	NS/NA
KIRC	Kidney renal clear cell carcinoma	-0.382	2.91e-13	24	319	-0.058	1.68e-16	NS/NA
KIRP	Kidney renal papillary cell carcinoma	-0.084	0.148	23	275	-0.024	0.000102	NS/NA
LAML	Acute Myeloid Leukemia	-0.315	3.12e-05	0	170	NA	NA	NS/NA
LGG	Brain Lower Grade Glioma	-0.172	6.97e-05	0	530	NA	NA	NS/NA
LIHC	Liver hepatocellular carcinoma	-0.177	0.000306	41	373	0.015	0.018	NS/NA
LUAD	Lung adenocarcinoma	-0.156	0.000644	21	456	0.024	0.0232	NS/NA
LUSC	Lung squamous cell carcinoma	0.004	0.933	8	370	NA	NA	NS/NA
OV	Ovarian serous cystadenocarcinoma	-0.7	0.0433	0	9	NA	NA	NS/NA
PAAD	Pancreatic adenocarcinoma	-0.052	0.484	4	179	NA	NA	NS/NA
PCPG	Pheochromocytoma and Paraganglioma	-0.182	0.0126	3	184	NA	NA	NS/NA
PRAD	Prostate adenocarcinoma	-0.154	0.000365	35	498	-0.012	1.33e-05	NS/NA
READ	Rectum adenocarcinoma	-0.168	0.0939	2	99	NA	NA	NS/NA
SARC	Sarcoma	-0.184	0.00281	0	263	NA	NA	NS/NA
SKCM	Skin Cutaneous Melanoma	-0.107	0.0199	1	471	NA	NA	NS/NA
STAD	Stomach adenocarcinoma	-0.038	0.463	0	372	NA	NA	NS/NA
TGCT	Testicular Germ Cell Tumors	-0.282	0.000383	0	156	NA	NA	NS/NA
THCA	Thyroid carcinoma	-0.188	7.79e-06	50	509	0.036	0.0238	NS/NA
THYM	Thymoma	-0.018	0.843	2	120	NA	NA	NS/NA
UCEC	Uterine Corpus Endometrial Carcinoma	-0.345	2.52e-14	34	431	-0.254	6.46e-71	Decreased

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Primary tumor tissue from TCGA > Normal tumor tissue from HPA

>The Cancer Genome Atlas (TCGA) [ TOP ]
There is no record.

> The Human Protein Atlas (HPA)

[ TOP ]

Tissue	Level	Level Name
Adrenal gland	1	Low
Appendix	2	Medium
Bone marrow	1	Low
Breast	1	Low
Bronchus	2	Medium
Caudate	1	Low
Cerebellum	1	Low
Cerebral cortex	1	Low
Cervix, uterine	1	Low
Colon	2	Medium
Duodenum	2	Medium
Endometrium	0	Not detected
Epididymis	1	Low
Esophagus	0	Not detected
Fallopian tube	0	Not detected
Gallbladder	1	Low
Heart muscle	1	Low
Hippocampus	1	Low
Kidney	2	Medium
Liver	0	Not detected
Lung	0	Not detected
Lymph node	2	Medium
Nasopharynx	2	Medium
Oral mucosa	0	Not detected
Ovary	0	Not detected
Pancreas	0	Not detected
Parathyroid gland	0	Not detected
Placenta	2	Medium
Prostate	2	Medium
Rectum	1	Low
Salivary gland	0	Not detected
Seminal vesicle	1	Low
Skeletal muscle	0	Not detected
Skin	3	High
Small intestine	1	Low
Smooth muscle	0	Not detected
Soft tissue	1	Low
Spleen	2	Medium
Stomach	1	Low
Testis	2	Medium
Thyroid gland	1	Low
Tonsil	1	Low
Urinary bladder	0	Not detected
Vagina	1	Low

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Association between expresson and subtype > Overall survival analysis based on expression > Association between expresson and stage > Association between expresson and grade

> Subtype

[ TOP ]

Association between expresson and subtype.

Cancer	Full Name	# Patients	P Value (Kruskal-Wallis)	Association	Source
BLCA	Bladder urothelial carcinoma	128	0.704	NS	24476821
BRCA	Breast invasive carcinoma	521	1.83e-38	Significant	23000897
COAD	Colon adenocarcinoma	149	0.444	NS	22810696
GBM	Glioblastoma multiforme	157	0.000865	Significant	26824661
HNSC	Head and Neck squamous cell carcinoma	279	2.85e-07	Significant	25631445
KIRP	Kidney renal papillary cell carcinoma	161	0.0347	Significant	26536169
LGG	Brain Lower Grade Glioma	513	1.35e-19	Significant	26824661
LUAD	Lung adenocarcinoma	230	0.483	NS	25079552
LUSC	Lung squamous cell carcinoma	178	0.11	NS	22960745
OV	Ovarian serous cystadenocarcinoma	287	0.0259	Significant	21720365
PRAD	Prostate adenocarcinoma	333	0.00289	Significant	26544944
READ	Rectum adenocarcinoma	67	0.89	NS	22810696
SKCM	Skin Cutaneous Melanoma	315	0.246	NS	26091043
STAD	Stomach adenocarcinoma	277	0.0178	Significant	25079317
THCA	Thyroid carcinoma	391	2.31e-33	Significant	25417114
UCEC	Uterine Corpus Endometrial Carcinoma	232	0.275	NS	23636398

> Overall survival

[ TOP ]

Overall survival analysis based on expression.

Cancer	Full Name	# Patients	Hazard Ratio	P Value (Log Rank Test)	Association
BLCA	Bladder urothelial carcinoma	405	0.605	0.0159	Longer
BRCA	Breast invasive carcinoma	1079	1.404	0.155	NS
CESC	Cervical and endocervical cancers	291	0.498	0.0237	Longer
COAD	Colon adenocarcinoma	439	0.701	0.179	NS
ESCA	Esophageal carcinoma	184	1.765	0.0795	NS
GBM	Glioblastoma multiforme	158	0.833	0.473	NS
HNSC	Head and Neck squamous cell carcinoma	518	0.486	0.000315	Longer
KIRC	Kidney renal clear cell carcinoma	531	1.879	0.00213	Shorter
KIRP	Kidney renal papillary cell carcinoma	287	2.072	0.0683	NS
LAML	Acute Myeloid Leukemia	149	1.634	0.0932	NS
LGG	Brain Lower Grade Glioma	511	2.147	0.00285	Shorter
LIHC	Liver hepatocellular carcinoma	365	1.853	0.0168	Shorter
LUAD	Lung adenocarcinoma	502	0.719	0.132	NS
LUSC	Lung squamous cell carcinoma	494	0.932	0.719	NS
OV	Ovarian serous cystadenocarcinoma	303	0.623	0.0244	Longer
PAAD	Pancreatic adenocarcinoma	177	0.946	0.859	NS
PCPG	Pheochromocytoma and Paraganglioma	179	0	0.125	NS
PRAD	Prostate adenocarcinoma	497	3.229	0.283	NS
READ	Rectum adenocarcinoma	159	0.827	0.736	NS
SARC	Sarcoma	259	1.058	0.845	NS
SKCM	Skin Cutaneous Melanoma	459	0.568	0.00222	Longer
STAD	Stomach adenocarcinoma	388	0.718	0.15	NS
TGCT	Testicular Germ Cell Tumors	134	504364200.231	0.36	NS
THCA	Thyroid carcinoma	500	0.543	0.396	NS
THYM	Thymoma	119	0	0.00913	Longer
UCEC	Uterine Corpus Endometrial Carcinoma	543	1.379	0.273	NS

> Stage

[ TOP ]

Association between expresson and stage.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
BLCA	Bladder urothelial carcinoma	406	-0.16	0.00125	Lower
BRCA	Breast invasive carcinoma	1071	-0.038	0.209	NS
CESC	Cervical and endocervical cancers	167	-0.045	0.564	NS
COAD	Colon adenocarcinoma	445	-0.088	0.0635	NS
ESCA	Esophageal carcinoma	162	0.023	0.773	NS
HNSC	Head and Neck squamous cell carcinoma	448	-0.162	0.000596	Lower
KIRC	Kidney renal clear cell carcinoma	531	0.102	0.0187	Higher
KIRP	Kidney renal papillary cell carcinoma	260	0.005	0.933	NS
LIHC	Liver hepatocellular carcinoma	347	0.041	0.441	NS
LUAD	Lung adenocarcinoma	507	-0.089	0.0451	Lower
LUSC	Lung squamous cell carcinoma	497	-0.063	0.161	NS
OV	Ovarian serous cystadenocarcinoma	302	0.046	0.423	NS
PAAD	Pancreatic adenocarcinoma	176	0.021	0.778	NS
READ	Rectum adenocarcinoma	156	0.066	0.414	NS
SKCM	Skin Cutaneous Melanoma	410	-0.028	0.566	NS
STAD	Stomach adenocarcinoma	392	0.013	0.802	NS
TGCT	Testicular Germ Cell Tumors	81	0.156	0.165	NS
THCA	Thyroid carcinoma	499	-0.011	0.802	NS
UCEC	Uterine Corpus Endometrial Carcinoma	501	-0.016	0.716	NS

> Grade

[ TOP ]

Association between expresson and grade.

Cancer	Full Name	# Patients	R Value (Spearman)	P Value (Spearman)	Association
CESC	Cervical and endocervical cancers	272	0.113	0.0624	NS
HNSC	Head and Neck squamous cell carcinoma	498	0.058	0.199	NS
KIRC	Kidney renal clear cell carcinoma	525	0.113	0.00945	Higher
LGG	Brain Lower Grade Glioma	514	0.043	0.332	NS
LIHC	Liver hepatocellular carcinoma	366	-0.099	0.0577	NS
OV	Ovarian serous cystadenocarcinoma	296	0.007	0.901	NS
PAAD	Pancreatic adenocarcinoma	176	-0.048	0.527	NS
STAD	Stomach adenocarcinoma	406	0.047	0.343	NS
UCEC	Uterine Corpus Endometrial Carcinoma	534	0.216	4.75e-07	Higher

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Targets inferred by reverse engineering method > Targets identified by ChIP-seq data

> Targets inferred by reverse engineering method [ TOP ]

> Targets identified by ChIP-seq data [ TOP ]

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Drugs from DrugBank database

> Drugs from DrugBank database [ TOP ]
There is no record for MSL3.

Summary
Symbol	MSL3
Name	male-specific lethal 3 homolog (Drosophila)
Aliases	MSL3L1; male-specific lethal-3 (Drosophila)-like 1; male-specific lethal 3-like 1 (Drosophila); MSL3-like 1; ......
Location	Xp22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Cancer Gene Databases	ONGene (Oncogene) , TSGene (Tumor suppressor gene) , NCG (Network of Cancer Genes)
Content	> Protein-Protein Interaction Network > miRNA Regulatory Relationship > Interactions from Text Mining

> Protein-Protein Interaction Network [ TOP ]

> miRNA Regulatory Relationship [ TOP ]

> Interactions from Text Mining [ TOP ]
There is no record for MSL3.